Iron and / or calcium absorption promoter

Abstract

To provide a novel iron and / or calcium absorption promoter.SOLUTION: An iron and / or calcium absorption promoter contains, as an active ingredient, one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an agent for enhancing absorption of iron and / or calcium. [Background technology]

[0002] Minerals are a general term for anything other than the four main elements that make up living organisms (oxygen, carbon, hydrogen, and nitrogen). Of these, 16 types of minerals are known as essential minerals that are essential for regulating and maintaining bodily functions. Mineral deficiencies can cause a variety of physical disorders, but because minerals cannot be synthesized in the body, they must be supplemented through intake. However, current diets tend to result in deficiencies in minerals such as iron and calcium.

[0003] Iron, an essential mineral, is a component of hemoglobin and various enzymes. Iron deficiency is known to cause anemia, impaired motor function, and impaired cognitive function. The body loses approximately 1-2 mg of iron each day through metabolism, and this loss must be replenished by absorbing iron from food. However, iron is one of the nutrients that is easily deficient, and actual intake is often lower than the recommended intake. Iron deficiency is particularly prevalent among menstruating women and growing children.

[0004] Furthermore, calcium, an essential mineral, is mostly found in bones and teeth bound with phosphate, with only a small amount present in blood, muscles, nerves, etc. Calcium deficiency is known to cause osteoporosis, neuralgia, etc.

[0005] Therefore, with the aim of preventing iron and calcium deficiency and enhancing absorption, foods and supplements that promote absorption have been developed (for example, Patent Documents 1, 2, 3, etc.). [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-162485 [Patent Document 2] Japanese Patent Application Laid-Open No. 2009-067688 [Patent Document 3] Patent No. 6872699 Summary of the Invention [Problem to be solved by the invention]

[0007] An object of the present invention is to provide a new agent for enhancing absorption of iron and / or calcium. [Means for solving the problem]

[0008] The present inventors have conducted extensive research to solve the above problems and have found that the following inventions meet the above objectives, thereby completing the present invention. <1> An iron and / or calcium absorption promoter containing, as an active ingredient, one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract. <2> The composition is an oral composition. <1> 1. The iron and / or calcium absorption promoter according to claim 1. <3> The amount of the sea buckthorn component contained in the food product is 100 mg or more and 50,000 mg or less in terms of solid content, as a daily intake amount for an adult human. <1> or <2> 1. The iron and / or calcium absorption promoter according to claim 1. [Effects of the Invention]

[0009] According to the present invention, a new agent for enhancing absorption of iron and / or calcium is provided. DETAILED DESCRIPTION OF THE INVENTION

[0010] The following describes in detail the embodiments of the present invention, but the explanation of the constituent elements described below is one example (typical example) of the embodiment of the present invention, and the present invention is not limited to the following content unless the gist of the present invention is changed. Note that when the expression "to" is used in this specification, it is used as an expression including the numerical values ​​or physical property values ​​before and after it.

[0011] The present invention relates to an absorption enhancer for iron and / or calcium (hereinafter, sometimes referred to as "the absorption enhancer of the present invention") containing, as an active ingredient, one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract.

[0012] (Sea Buckthorn) Sea buckthorn (scientific name: Hippophae rhamnoides L., English name: Sea buckthorn) is a plant of the Elaeaceae family native to Europe and Asia. It is a thorny deciduous shrub or tree that grows to a height of about 2 to 5 m. The sea buckthorn components contained in the iron and / or calcium absorption enhancer of the present invention, namely sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract, are obtained from sea buckthorn fruit. The sea buckthorn fruit may be used in the form of pulp after the peel and seeds have been removed, or in the form of fruit containing the peel and pulp after the seeds have been removed, or in the form of fruit containing the peel, pulp, and seeds without removing the peel and seeds.

[0013] (Seabuckthorn juice) Seabuckthorn juice is a liquid or semi-liquid substance obtained by squeezing or crushing seabuckthorn fruits. Examples of seabuckthorn juice include straight juice obtained by squeezing seabuckthorn fruits, concentrated juice obtained by concentrating straight juice, diluted juice obtained by diluting straight juice, puree obtained by crushing seabuckthorn fruits using a mixer, grinder, crusher, crusher, etc., and paste obtained by concentrating the puree, and mixtures of these are also possible. Seabuckthorn juice may also be used after squeezing or crushing seabuckthorn fruits and then centrifuging, filtering, or straining as appropriate. Straining can be performed by passing the juice through a mesh (e.g., 40 to 60 mesh). Straining can remove at least a portion of the skin, seeds, and fibrous material of the pulp.

[0014] For example, liquid or semi-liquid sea buckthorn juice obtained by squeezing or crushing sea buckthorn fruits, liquid or semi-liquid sea buckthorn juice obtained by squeezing or crushing sea buckthorn fruits and then straining them, or a mixture thereof can be used.

[0015] (Dried sea buckthorn juice) The dried sea buckthorn juice is obtained by drying sea buckthorn juice. Drying can be carried out by known drying methods such as sun drying, heat drying, vacuum drying, lyophilization (freeze drying), spray drying, etc. Alternatively, the dried product may be powdered during drying using spray drying or the like to obtain a dry powder.

[0016] (Dried sea buckthorn fruit) The dried sea buckthorn fruit is obtained by drying sea buckthorn fruits. Drying can be carried out by known drying methods such as sun drying, heat drying, vacuum drying, lyophilization (freeze drying), spray drying, etc. Furthermore, the fruit may be crushed or pulverized as appropriate during drying to form a pulverized or crushed product.

[0017] (Sea Buckthorn Fruit Extract) Seabuckthorn fruit extract is a solution in which components in seabuckthorn fruit are extracted in a solvent. The seabuckthorn fruit extract may be obtained by immersing seabuckthorn fruit directly in a solvent, or by immersing seabuckthorn fruit in a solvent after crushing or drying the fruit as appropriate.

[0018] (Dried sea buckthorn fruit extract) The dried sea buckthorn fruit extract is obtained by drying the sea buckthorn fruit extract. Drying can be performed by known drying methods such as sun drying, heat drying, vacuum drying, lyophilization (freeze drying), spray drying, etc. Alternatively, the dried product may be powdered during drying using spray drying or the like to obtain a dry powder.

[0019] In particular, the sea buckthorn component of the absorption enhancer of the present invention preferably contains one or more selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, and dried sea buckthorn fruit, and more preferably contains sea buckthorn juice and / or dried sea buckthorn juice.

[0020] (Promotes absorption of iron and / or calcium) The absorption enhancer of the present invention can enhance the absorption of iron and / or calcium. The absorption enhancer of the present invention can enhance the absorption of iron, such as non-heme iron, by virtue of the sea buckthorn component. Furthermore, by ingesting the absorption enhancer of the present invention with meals, the sea buckthorn component enhances the absorption of iron and calcium contained in the meal. This can increase the absorption of iron and calcium into the body.

[0021] (Oral Composition) The absorption enhancer of the present invention can be used as a food composition or a pharmaceutical composition, and is preferably in the form of an oral composition.

[0022] The content of the sea buckthorn component in the absorption enhancer of the present invention is designed according to the method of ingestion, etc., so that the amount of the sea buckthorn component, converted into solid content, is the desired daily intake amount for an adult human. For example, the absorption enhancer of the present invention preferably contains 100 mg or more of the sea buckthorn component, converted into solid content, as the daily intake amount for an adult human, more preferably 500 mg or more, and even more preferably 1000 mg or more. There is no particular upper limit to the content of the sea buckthorn component in the absorption enhancer of the present invention, but the daily intake amount for an adult human is preferably 50,000 mg or less, more preferably 30,000 mg or less, and even more preferably 10,000 mg or less, as converted into solid content. The amount of sea buckthorn juice converted into solid content is the mass of the sea buckthorn juice excluding water. Sea buckthorn juice usually contains about 80 to 90% water by mass, and therefore the amount converted into solid content is about 10 to 20% by mass of the sea buckthorn juice. The amount of sea buckthorn fruit extract converted into solid content is the mass of the sea buckthorn fruit extract excluding the solvent. For the dried sea buckthorn juice, dried sea buckthorn fruit, and dried sea buckthorn fruit extract, the masses can be used as they are as the amount converted into solid content.

[0023] The absorption enhancer of the present invention may be taken once a day or in divided doses multiple times a day (e.g., 2 to 4 times) so that the sea buckthorn component reaches the above-mentioned intake amount. Furthermore, the absorption enhancer of the present invention can be taken continuously, and can be taken continuously for several days to several weeks or months. The daily intake amount refers to the total amount ingested or administered in one day, and when taken in divided doses multiple times a day, it is the total amount of these doses.

[0024] (Food composition) The absorption enhancer of the present invention is preferably a food composition containing sea buckthorn components for promoting the absorption of iron and / or calcium. By forming it into a food composition, it is easy to take it on a daily basis over the long term, and it can enhance the absorption of iron and / or calcium, which tend to be in short supply on a daily basis. This food composition includes not only general foods, but also foods and / or beverages taken for the purpose of maintaining or improving health, such as foods for special dietary uses, foods for specified health uses, foods with functional claims, foods with nutrient functions, nutritional supplements, health supplements, and supplements. Among these, foods with health functions, such as foods for specified health uses, foods with functional claims, and foods with nutrient functions, are preferred embodiments.

[0025] The form of the food composition is not particularly limited, and may be any of solid, liquid, semi-solid, gel, sol, etc. Foods and beverages are not particularly limited, and examples of foods include sausage, ham, processed seafood products, jelly, candy, chewing gum, etc. Beverages include various fruit juice drinks, teas, soft drinks, alcoholic beverages, energy drinks, etc. In addition to the sea buckthorn component, the food composition may contain additives such as colorants, preservatives, thickening stabilizers, antioxidants, bleaching agents, antibacterial and antifungal agents, acidulants, seasonings, emulsifiers, strengthening agents, flavorings, and sweeteners.

[0026] When seabuckthorn juice is used, beverages (liquid beverages, purees, etc.) are one of the preferred embodiments. By making it into a beverage, the seabuckthorn juice can be used as is, and its content can be easily adjusted. When making it into a beverage, the content of seabuckthorn juice in the beverage (mass of seabuckthorn juice / mass of beverage x 100 (%)) can be 30% by mass or more, 50% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, 90% by mass or more, etc. Furthermore, there is no particular limit on the upper limit of the content of seabuckthorn juice in the beverage, and the seabuckthorn juice itself may be used as the beverage, or the upper limit may be set appropriately, such as 99.99% by mass or less, 99.98% by mass or less, etc.

[0027] (Pharmaceutical composition) The absorption enhancer of the present invention can be a pharmaceutical composition containing a sea buckthorn component for promoting the absorption of iron and / or calcium. This pharmaceutical composition includes both pharmaceuticals and quasi-drugs. When used as a pharmaceutical composition, the absorption enhancer of the present invention basically contains a sea buckthorn component and a pharmaceutically acceptable carrier.

[0028] The dosage form of the pharmaceutical composition is not particularly limited and may be a solid or liquid preparation. Specific examples include powders, granules, tablets, capsules, lozenges, suspensions, emulsions, syrups, and elixirs. Pharmaceutically acceptable carriers include binders, stabilizers, excipients, diluents, pH buffers, thickeners, colorants, dispersants, emulsifiers, suspending agents, preservatives, disintegrants, solubilizers, and dissolution aids.

[0029] The use of the absorption enhancer of the present invention is not limited to humans, but may also be directed to animals other than humans, such as dogs and cats. Therefore, the absorption enhancer of the present invention may be used in animal food compositions such as pet food or animal pharmaceutical compositions. [Example]

[0030] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to the following examples as long as the gist of the present invention is not changed.

[0031] A randomized, placebo-controlled crossover study was conducted to evaluate the effect of sea buckthorn drink intake on enhancing iron and calcium absorption.

[0032] 1. Test food [Test food: Sea buckthorn drink (a drink containing sea buckthorn juice)] Ingredients (mass%): Seabuckthorn puree (seabuckthorn fruit is put into a blender, passed through a mesh to remove the skin residue and seeds, and then flash-sterilized at high temperature, solid content approximately 10%) 99.95%, Stevia (Asteraceae) 0.05% ·Form: Beverage Packaging: Packed in a single package for the duration of consumption Storage method: Store in a cool, dark place away from direct sunlight.

[0033] [Control food: placebo drink (drink not containing sea buckthorn juice)] Ingredients (mass%): Water 92.14%, Granulated sugar 5%, Casamas Yellow color 0.5%, Kiriya Red color 0.02%, 85% Phosphoric acid 0.75%, Creamer powder 1.2%, FE base (No. 36833) 0.04%, Vitamin C 0.3%, Stevia (Asteraceae) 0.05% ·Form: Beverage Packaging: Packed in a single package for the duration of consumption Storage method: Store in a cool, dark place away from direct sunlight.

[0034] 2. Dosage and method of intake The test food was taken at a dose of 30 mL per day. 10 mL of the test food was diluted with water and taken three times a day (breakfast, lunch, and dinner).

[0035] 3. Test Method Randomized, double-blind, placebo-controlled, crossover study 1) SCR testing will be conducted on 60 people. The SCR testing will involve informed consent, a subject background questionnaire, physical measurements, blood pressure, pulse, and clinical tests (blood tests, urine tests). 2) After fasting for at least five hours, subjects will arrive at the hospital at 11:00 AM to have their weight, blood pressure, pulse, and clinical tests (blood tests and urine tests) taken. After arrival, on the first day, lunch will be served at 1:00 PM and dinner at 7:00 PM (total calories of the meals provided: 1,130 kcal). Two 500 mL plastic bottles of drinking water (1,000 mL) will be provided and subjects will be required to consume as needed. Anything beyond that will be allowed ad libitum, but the amount provided will be recorded. Subjects will be allowed to go to bed around 10:00 PM. On the second day, subjects will be woken by 7:00 AM and made to urinate. They will also be required to have a bowel movement by breakfast time. Blood pressure and pulse will be measured, and subjects will be given breakfast and test food (sea buckthorn juice or placebo drink) at 9:00 AM, followed by lunch and test food (sea buckthorn juice or placebo drink) at 1:00 PM, and dinner and test food (sea buckthorn juice or placebo drink) at 7:00 PM (total calories of the meals provided: 1,647 kcal). On the second day, urine was collected for two hours from the start of breakfast at 9:00 a.m. until 5:00 p.m. (The urine collection bottle was changed every two hours.) After 5:00 p.m., urine was collected until the first urine was collected upon waking the next morning. Upon discharge on the third day, weight, blood pressure, pulse rate, and clinical tests (blood and urine tests) were again conducted, completing Phase I of the study. 3) Allow a washout period of at least one week. 4) After washout, subjects will be given a test food (sea buckthorn juice or placebo drink) different from that in Period I in Period II, and the same procedure as in Period I will be carried out for 2 nights and 3 days. 5) During the test period, you will be required to keep a lifestyle diary.

[0036] Table 1 shows the overall test schedule, and Table 2 shows the time schedule for the overnight test.

[0037] [Table 1]

[0038] [Table 2]

[0039] 4.Results [Subject background] A screening test was conducted on 45 subjects, and 35 subjects who met the inclusion criteria and did not violate the exclusion criteria were selected, and 1 subject was selected as a preliminary subject. Selection criteria (1) Those who are not suffering from any illness (2) Men and women aged 20 to 59 (3) BMI is 30 kg / m 2 Those under (4) Subjects who can provide written consent to voluntarily participate in the study (5) People who can drink sea buckthorn juice on a regular basis ·Exclusion criteria (1) Those who are currently diagnosed with iron deficiency anemia and are receiving medication (2) Those currently receiving medication for any disease (3) People who consume foods containing ingredients related to the test food or health foods (4) Anyone with a serious disease of glucose metabolism, lipid metabolism, liver function, kidney function, heart, circulatory system, respiratory system, endocrine system, immune system, nervous system, or mental illness, or anyone with a history of such a disease. (5) Subjects who have had abnormalities in clinical test values ​​and are judged to have problems participating in the study (6) Those who are currently undergoing treatment for a disease or have a history of a serious disease that required medication. (7) Subjects who are at risk of developing allergies related to the study (8) Subjects who are deemed unsuitable as subjects based on the results of the lifestyle questionnaire. (9) Subjects who are participating in other clinical studies at the start of this study (10) Any person who is deemed unsuitable for participation in the study by the investigator (or the person responsible for the study)

[0040] During visits to the hospital in periods I and II, three patients dropped out: two for personal reasons and one for non-compliance with compliance requirements. Therefore, the subjects for analysis were the 32 patients who participated in the study. Of the 32 patients, 19 were male and 13 were female. Table 3 shows the subject background.

[0041] [Table 3]

[0042] [evaluation] Evaluation items: Urinary mineral (iron, calcium) excretion (creatinine corrected) Evaluation method: A paired t-test was performed at each intake period to compare between groups.

[0043] [Urinary mineral (iron, calcium) excretion results] It is known that the amount of minerals excreted in urine correlates with the amount of minerals absorbed, and an increase in this amount indicates an increase in the amount of minerals absorbed. The results of measuring the amount of minerals (Fe, Ca) in urine are shown in Table 4.

[0044] [Table 4]

[0045] The results of the measurements showed that the amount of iron and calcium excreted in urine when sea buckthorn juice was consumed increased significantly compared to when a placebo was consumed, indicating that consumption of sea buckthorn juice increases the amount of iron and calcium absorbed.

Claims

1. An iron and / or calcium absorption promoter containing, as an active ingredient, one or more sea buckthorn components selected from the group consisting of sea buckthorn juice, dried sea buckthorn juice, dried sea buckthorn fruit, sea buckthorn fruit extract, and dried sea buckthorn fruit extract.

2. The iron and / or calcium absorption enhancer according to claim 1, which is an oral composition.

3. 3. The iron and / or calcium absorption promoter according to claim 1, wherein the amount of the sea buckthorn component to be ingested per day by an adult human is 100 mg to 50,000 mg in terms of solid content.

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