Preservative for skin external preparations containing caprylhydroxamic acid, 4'-hydroxyacetophenone and polyol, and cosmetic composition containing same

Abstract

The present application relates to a preservative for external skin preparations, comprising caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and a polyol, and uses thereof. The preservative for external skin preparations according to one embodiment exhibits excellent antibacterial or antiseptic effects against bacteria and fungi. In particular, the preservative for external skin preparations according to one embodiment contains 4'-hydroxyacetophenone and caprylyl glycol as active ingredients, and when applied to a cosmetic composition containing a surfactant, the antibacterial or antiseptic effects against bacteria and fungi are not reduced, and a significantly excellent antibacterial or antiseptic effect is maintained. Thus, the preservative for external skin preparations according to one embodiment can be usefully used to perform antibacterial, preservative or antiseptic treatment on various cosmetic compositions or external skin preparations, including cleansing products.

Description

[Technical field]

[0001] The present invention relates to a preservative for external skin preparations, which comprises caprylhydroxamic acid, 4'-hydroxyacetophenone and a polyol, and a cosmetic composition containing the same.

[0002] This patent application claims priority to Korean Patent Application No. 10-2022-0028224, filed with the Korean Intellectual Property Office on March 4, 2022, the disclosure of which is incorporated herein by reference. [Background technology]

[0003] Cosmetic products cannot avoid contamination by microorganisms during the manufacturing or use process, and therefore preservatives capable of improving the preservative power of the products are essential in the manufacture of cosmetic products. Such preservatives that are widely used include paraben preservatives, imidazolidinyl urea, phenoxyethanol, etc. However, although the above preservatives have the advantages of strong antibacterial properties and excellent preservative power, they are also widely known to have the disadvantages of causing toxicity, skin irritation, allergies, etc. Therefore, there is a need to develop safe preservatives that do not cause skin irritation and have strong preservative power.

[0004] As part of such research, the development of preservatives using relatively safe ingredients such as acetophenone derivatives and caprylyl glycol has been ongoing (Korean Patent Registration No. 10-2262467), but the present inventors have confirmed that the antibacterial activity of acetophenone derivatives and caprylyl glycol is significantly reduced in an environment in which a surfactant is present, and that there is a limit to their application as preservatives or preservatives in skin external preparations (e.g., cosmetic compositions for cleaning) that contain such surfactants. Therefore, in order to apply acetophenone derivatives and caprylyl glycol as preservatives or preservatives, it is necessary for them to maintain excellent antibacterial activity even in an environment in which the surfactant is present, but research on this is still lacking. Summary of the Invention [Problem to be solved by the invention]

[0005] In order to solve the above problems, the inventors of the present invention developed a preservative for external skin preparations, which contains caprylhydroxamic acid, 4'-hydroxyacetophenone and a polyol, and confirmed that the preservative exhibits excellent antibacterial and antiseptic properties when applied to cosmetic compositions containing surfactants, thereby completing the present invention.

[0006] One object of the present invention is to provide a preservative for topical skin preparations comprising caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol.

[0007] Another object of the present invention is to provide a cosmetic composition containing the above preservative for external skin preparations.

[0008] It is still another object of the present invention to provide a method for preparing a preservative for external skin preparations, comprising the step of mixing caprylhydroxamic acid, 4'-hydroxyacetophenone and caprylyl glycol.

[0009] It is still another object of the present invention to provide a method for preparing a cosmetic composition, comprising the step of adding a preservative for external skin preparations.

[0010] It is still another object of the present invention to provide a method for antibacterial, preservative or antiseptic treatment of a cosmetic composition, comprising the step of adding a preservative for external skin preparations.

[0011] Yet another object of the present invention is to provide use of a composition comprising caprylhydroxamic acid, 4'-hydroxyacetophenone and caprylyl glycol for antibacterial, preservative or antiseptic treatment of an external skin preparation or cosmetic composition.

[0012] Yet another object of the present invention is to provide a use of a composition comprising caprylhydroxamic acid, 4'-hydroxyacetophenone and caprylyl glycol for producing a preservative for external skin preparations, or a cosmetic composition for antibacterial or antiseptic purposes.

[0013] However, the technical problem to be solved by the present invention is not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by a person having ordinary skill in the art from the following description. [Means for solving the problem]

[0014] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Generally, the nomenclature used herein is one that is widely known and commonly used in the art.

[0015] One embodiment provides a preservative for a skin topical preparation, comprising caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP), and caprylyl glycol.

[0016] The preservative for the skin external preparation may further include one or more polyols selected from the group consisting of glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, and alkanediols having 3 to 12 carbon atoms. The alkanediols having 3 to 12 carbon atoms may be, but are not limited to, octanediol, decanediol, propanediol, butanediol, pentanediol, hexanediol, heptanediol, undecanediol, dodecanediol, or combinations thereof. Preferably, the preservative for the skin external preparation may further include dipropylene glycol.

[0017] According to one embodiment, a preservative for external skin preparations containing two selected from caprylhydroxamic acid, 4'-hydroxyacetophenone, and caprylyl glycol can exhibit antibacterial effects in a general environment, but the antibacterial and antiseptic effects are significantly reduced in an environment in which a surfactant is present. On the other hand, a preservative for external skin preparations containing caprylhydroxamic acid, 4'-hydroxyacetophenone, and caprylyl glycol according to one embodiment can solve such problems and exhibit excellent antibacterial and antiseptic effects against both bacteria and fungi (yeast and mold) even in cosmetic compositions containing various surfactants.

[0018] The preservative for external skin preparations may contain about 5 to 15 wt % of the caprylhydroxamic acid based on the total weight. Specifically, the preservative for external skin preparations may contain about 5 to 10 wt % or about 10 to 15 wt % of the caprylhydroxamic acid based on the total weight. According to one embodiment, if the preservative for external skin preparations contains the caprylhydroxamic acid in an amount outside the above range based on the total weight, the antibacterial or antiseptic effect may be reduced, or stability may be reduced, such as solidification, precipitation, reduced dissolving power, reduced emulsifying power or solubilizing power, or skin irritation may be induced, resulting in reduced safety.

[0019] The preservative for external skin preparations may contain 4'-hydroxyacetophenone in an amount of about 25 to 30 wt% based on the total weight. Specifically, the preservative for external skin preparations may contain 4'-hydroxyacetophenone in an amount of about 25 to 27 wt% or about 27 to 30 wt% based on the total weight. According to one embodiment, if the preservative for external skin preparations contains 4'-hydroxyacetophenone in an amount outside the above range based on the total weight, the antibacterial or antiseptic effect may be reduced, or stability may be reduced, such as solidification, precipitation, reduced dissolving power, reduced emulsifying power or solubilizing power, or skin irritation may be induced, resulting in reduced safety.

[0020] The preservative for external skin preparations may contain about 13 to 15 wt % of the caprylyl glycol based on the total weight. Specifically, the preservative for external skin preparations may contain about 13 to 14 wt % or about 14 to 15 wt % of the caprylyl glycol based on the total weight. According to one embodiment, if the preservative for external skin preparations contains the caprylyl glycol in an amount outside the above range based on the total weight, the antibacterial or antiseptic effect may be reduced, or stability may be reduced, such as solidification, precipitation, reduced solubility, reduced emulsifying or solubilizing power, or skin irritation may be induced, resulting in reduced safety.

[0021] The preservative for external skin preparations may contain, based on the total weight, about 5 to 15 wt %, 5 to 10 wt %, or 10 to 15 wt % of the caprylhydroxamic acid, about 25 to 30 wt %, 25 to 27 wt %, or 27 to 30 wt % of the 4'-hydroxyacetophenone, and about 13 to 15 wt %, 13 to 14 wt %, or 14 to 15 wt % of the caprylyl glycol. Desirably, the preservative for external skin preparations may contain, based on the total weight, about 5 to 15 wt % of the caprylhydroxamic acid, about 25 to 30 wt % of the 4'-hydroxyacetophenone, and about 13 to 15 wt % of the caprylyl glycol.

[0022] The weight ratio of the caprylhydroxamic acid, the 4'-hydroxyacetophenone and the caprylyl glycol contained in the preservative for external skin preparation may be about 5 to 15, 5 to 10, or 10 to 15:25 to 30, 25 to 27, or 27 to 30:13 to 15, 13 to 14, or 14 to 15, and preferably the weight ratio of the caprylhydroxamic acid, the 4'-hydroxyacetophenone and the caprylyl glycol contained in the preservative for external skin preparation may be about 5 to 15:25 to 30:13 to 15.

[0023] According to one specific example, when the weight percentage or weight ratio of the caprylhydroxamic acid, the 4'-hydroxyacetophenone, and the caprylyl glycol contained in the preservative for external skin preparations is within the above-mentioned numerical range, the cosmetic composition containing various surfactants exhibits excellent antibacterial and antiseptic effects against both bacteria and fungi (yeast and mold), and when the weight percentage or weight ratio of the caprylhydroxamic acid, the 4'-hydroxyacetophenone, and the caprylyl glycol contained in the preservative for external skin preparations is outside the above-mentioned numerical range, the antibacterial and antiseptic effects against bacteria and fungi (yeast and mold) (especially the antibacterial and antiseptic effects against mold) may be significantly reduced in the cosmetic composition containing various surfactants.

[0024] The preservative for external skin preparations may contain one or more polyols selected from the group consisting of glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, and alkanediols having 3 to 12 carbon atoms in an amount of about 38 to 57% by weight, 38 to 55% by weight, 38 to 50% by weight, 38 to 45% by weight, 38 to 40% by weight, 40 to 57% by weight, 40 to 55% by weight, 40 to 50% by weight, 40 to 45% by weight, 45 to 57% by weight, 45 to 55% by weight, 45 to 50% by weight, 50 to 57% by weight, 50 to 55% by weight, or 55 to 57% by weight, based on the total weight. According to one specific example, if the preservative for topical skin preparations contains the polyol in an amount outside the above numerical range relative to the total weight, the antibacterial or antiseptic effect may be reduced, or stability may be reduced, such as solidification, precipitation, reduced dissolving power, reduced emulsifying power or solubilizing power, or skin irritation may be induced, resulting in reduced safety.

[0025] The preservative for the external skin preparation contains, based on the total weight, about 5 to 15 wt %, 5 to 10 wt %, or 10 to 15 wt % of the caprylhydroxamic acid, about 25 to 30 wt %, 25 to 27 wt %, or 27 to 30 wt % of the 4'-hydroxyacetophenone, about 13 to 15 wt %, 13 to 14 wt %, or 14 to 15 wt % of the caprylyl glycol, and about 15 to 20 wt % of the polyol. , about 38 to 57% by weight, 40 to 55% by weight, or 45 to 50% by weight, and preferably, the preservative for external skin preparations may contain, based on the total weight, about 5 to 15% by weight of the caprylhydroxamic acid, about 25 to 30% by weight of the 4'-hydroxyacetophenone, about 13 to 15% by weight of the caprylyl glycol, and about 38 to 57% by weight of the polyol.

[0026] The weight ratio of the caprylhydroxamic acid, the 4'-hydroxyacetophenone, the caprylyl glycol and the polyol contained in the preservative for external skin preparation may be about 5 to 15, 5 to 10, or 10 to 15:25 to 30, 25 to 27, or 27 to 30:13 to 15, 13 to 14, or 14 to 15:38 to 57, 40 to 55, or 45 to 50, and preferably the weight ratio of the caprylhydroxamic acid, the 4'-hydroxyacetophenone, the caprylyl glycol and the polyol contained in the preservative for external skin preparation may be about 5 to 15:25 to 30:13 to 15:38 to 57.

[0027] The preservative for the external skin preparation may further include disodium ethylenediaminetetraacetate (EDTA 2Na).

[0028] According to one specific example, when the preservative for external skin preparation according to one embodiment further contains EDTA 2Na, it can exhibit the most excellent antibacterial and preservative effects against both bacteria and fungi (yeast and mold) even in cosmetic compositions containing various surfactants.

[0029] The preservative for external skin preparations may contain the EDTA 2Na in an amount of about 0.5 to 10% by weight, 0.5 to 8% by weight, 0.5 to 5% by weight, 0.5 to 3% by weight, 0.5 to 1% by weight, 1 to 10% by weight, 1 to 8% by weight, 1 to 5% by weight, 1 to 3% by weight, 3 to 10% by weight, 3 to 8% by weight, 3 to 5% by weight, 5 to 10% by weight, 5 to 8% by weight, or 8 to 10% by weight, based on the total weight.

[0030] According to one embodiment, the preservative for external skin preparations may exhibit excellent antibacterial or antiseptic effects against various kinds of microorganisms (specifically, contaminating microorganisms). Specifically, the preservative for external skin preparations may inhibit the growth of or kill gram-positive bacteria, gram-negative bacteria, and fungi (e.g., yeast, mold, etc.). In particular, the preservative for external skin preparations exhibits excellent antibacterial or antiseptic effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, and Aspergillus brasiliensis, but is not limited thereto.

[0031] The term "topical skin preparation" as used herein is a concept that encompasses all compositions that are applied to the skin, including, for example, various types of cosmetics such as basic cosmetics, makeup cosmetics, and hair cosmetics; pharmaceutical compositions for topical administration, including medicines and quasi-drugs, such as ointments, creams, and lotions; and the like.

[0032] According to one embodiment, the skin preparation may include a surfactant. That is, the preservative for skin preparation may be used or applied to a skin preparation containing a surfactant, and in that case, it may exhibit a remarkably excellent antibacterial and antiseptic effect against both bacteria and fungi (yeast and mold). In other words, the preservative for skin preparation may be used for antibacterial or antiseptic treatment of a skin preparation containing a surfactant. The surfactant may be a natural surfactant, a synthetic surfactant, or a combination thereof. The surfactant may be a cationic surfactant, a nonionic surfactant, an anionic surfactant, an amphoteric surfactant, or a combination thereof. The surfactant may be coco-betaine (CAS No. 68424-94-2), lauryl glucoside, sodium laureth sulfate, cocamidopropyl betaine, or a combination thereof, but is not limited thereto.

[0033] According to one embodiment, the skin topical preparation may contain the surfactant in an amount of about 0.5 to 70% by weight based on the total weight of the skin topical preparation, but is not limited thereto, and may preferably contain the surfactant in an amount of about 1 to 50% by weight, 10 to 40% by weight, or 20 to 40% by weight.

[0034] The topical skin preparation may be a cleansing cosmetic composition.

[0035] The cleansing cosmetic composition may include, but is not limited to, shampoo, rinse, scalp cleanser, foaming cleanser, soap, cleansing oil, cleansing cream, face cleanser, body cleanser, toothpaste, oral cleanser, and the like.

[0036] As used herein, the term “preservative for topical skin preparations” may be used interchangeably with “antibacterial agent,” “preservative,” “antibacterial preservative,” “preservative preservative,” “antibacterial composition,” “preservative composition,” “antibacterial or preservative composition,” “antibacterial cosmetic composition,” “preservative cosmetic composition,” “antibacterial or preservative cosmetic composition,” etc.

[0037] As used herein, the term "antibacterial" refers to resistance to all contaminating microorganisms such as bacteria, mold, and yeast, "antibacterial power" or "antibacterial effect" refers to the defensive power or defensive effect against such contaminating microorganisms, and "preservative power" or "preservative effect" refers to the defensive power or defensive effect against spoilage caused by microbial contamination, and is a concept that includes antibacterial power and antibacterial effect.

[0038] As used herein, the term "preservative" refers to a substance that has antiseptic or antioxidant properties and prevents deterioration of a product for a long period of time and maintains its original state, and "preservative properties" refers to the protective power that prevents deterioration of a product for a long period of time and maintains its original state.

[0039] The preservative for external skin preparations may further include additives such as purified water, carriers, emulsifiers, moisturizers, skin conditioning agents, surfactants, chelating agents, antioxidants, preservatives, bactericides, stabilizers, preservatives, pH regulators, lubricants, solubilizers, and solvents. The preservative for external skin preparations may further include a substance that can supplementarily provide essential nutrients to the skin, or a substance that improves skin conditions, such as a functional substance that has an effect on wrinkles or an effect on improving whitening. The preservative for external skin preparations may further include an auxiliary, including, but not limited to, natural fragrances, cosmetic fragrances, or plant extracts.

[0040] Another aspect provides a cosmetic composition comprising the preservative for external skin preparations.

[0041] According to one embodiment, the cosmetic composition may include a surfactant. That is, the preservative for external skin preparations may be used or applied to a cosmetic composition containing a surfactant, and in that case, it may exhibit a remarkably excellent antibacterial and antiseptic effect against both bacteria and fungi (yeast and mold). In other words, the preservative for external skin preparations may be used for antibacterial or antiseptic treatment of a cosmetic composition containing a surfactant. The surfactant may be a natural surfactant, a synthetic surfactant, or a combination thereof. The surfactant may be a cationic surfactant, a nonionic surfactant, an anionic surfactant, an amphoteric surfactant, or a combination thereof. The surfactant may be, but is not limited to, coco-betaine (CAS No. 68424-94-2), lauryl glucoside, sodium laureth sulfate, cocamidopropyl betaine, or a combination thereof.

[0042] According to one embodiment, the cosmetic composition may contain the surfactant in an amount of about 0.5 to 70 wt % based on the total weight of the cosmetic composition, but is not limited thereto, and may preferably contain the surfactant in an amount of about 1 to 50 wt %, 10 to 40 wt %, or 20 to 40 wt %.

[0043] The cosmetic composition may be a cleansing cosmetic composition.

[0044] The cleansing cosmetic composition may include, but is not limited to, shampoo, rinse, scalp cleanser, foaming cleanser, soap, cleansing oil, cleansing cream, face cleanser, body cleanser, toothpaste, oral cleanser, and the like.

[0045] The cosmetic composition may contain the preservative for external skin preparations in an amount of about 0.0001 to 50% by weight based on the total weight of the cosmetic composition. Specifically, the cosmetic composition may contain the preservative for external skin preparations in an amount of about 0.0001 to 0.001% by weight, 0.001 to 0.01% by weight, 0.01 to 0.1% by weight, 0.1 to 1% by weight, 1 to 10% by weight, 10 to 20% by weight, 20 to 30% by weight, 30 to 40% by weight, or 40 to 50% by weight based on the total weight of the cosmetic composition. According to one specific example, if the cosmetic composition contains the preservative for topical skin preparations in an amount less than about 0.0001 wt % based on the total weight of the cosmetic composition, the antibacterial or antiseptic effect is reduced, and if the cosmetic composition contains the preservative for topical skin preparations in an amount exceeding about 50 wt % based on the total weight of the cosmetic composition, it may cause a decrease in stability, such as solidification, precipitation, a decrease in dissolving power, or a decrease in emulsifying or solubilizing power.

[0046] The cosmetic composition may further include an additive selected from the group consisting of purified water, a carrier, an emulsifier, a moisturizer, a skin conditioning agent, a surfactant, a chelating agent, an antioxidant, a preservative, a bactericide, a stabilizer, a preservative, a pH adjuster, a lubricant, a solubilizer, a solvent, and a combination thereof, but is not limited thereto. The cosmetic composition may further include a substance that can supplementarily provide essential nutrients to the skin, or a substance that improves the skin condition, for example, a functional substance that has an effect on wrinkles or an effect of improving whitening. The cosmetic composition may further include an auxiliary, including, but not limited to, a natural fragrance, a cosmetic fragrance, or a plant extract.

[0047] The cosmetic composition may be prepared in any dosage form commonly prepared in the art. Specifically, the cosmetic composition may be prepared in the form of, but is not limited to, a solution, an emulsion, a suspension, a softening lotion, a nutritious lotion, a massage cream, a nutritious cream, a pack, a gel, a cleanser, a foaming cleanser, a cleansing oil, a cleansing cream, a skin adhesive cosmetic, a lipstick, a powder, a makeup base, a foundation, a shampoo, a rinse, a scalp cleanser, a scalp lotion, a scalp cream, a scalp pack, a scalp gel, a scalp ointment, a scalp gel, a face cleanser, a body cleanser, a soap, a toothpaste, an oral cleanser, a paste, a lotion, an ointment, a gel, a cream, a patch, a spray, or an aerosol.

[0048] The carrier contained in the cosmetic composition may be selectively used depending on the formulation of the cosmetic. For example, when preparing an ointment, paste, cream or gel cosmetic, the carrier may be wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc., either alone or in combination. When preparing a powder or spray cosmetic, the carrier may be lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, chlorofluorohydrocarbon, propane / butane, dimethyl ether, etc., either alone or in combination. When preparing a cosmetic product in the form of a solution or emulsion, the carrier components may be water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil, sesame oil, glycerol aliphatic esters, polyethylene glycol, or fatty acid esters of sorbitan, either alone or in combination. When preparing a cosmetic product in the form of a suspension, the carrier components may be water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters, polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar, tracant, either alone or in combination. When producing a cosmetic product in the form of a soap, the following may be used as carrier components, either alone or in combination: alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolysates, isethionates, lanolin derivatives, fatty alcohols, vegetable oils, glycerol, sugars, and the like.

[0049] Among the terms or elements mentioned in the cosmetic composition, those mentioned in the description of the preservative for topical skin preparations are understood to be the same as those mentioned in the description of the preservative for topical skin preparations above.

[0050] Yet another embodiment provides a method of making a preservative for a skin topical agent comprising the step of combining caprylhydroxamic acid, 4'-hydroxyacetophenone, and caprylyl glycol.

[0051] The method may further include the step of adding and mixing one or more polyols selected from the group consisting of glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, and alkanediols having 3 to 12 carbon atoms.

[0052] The method may further comprise the step of introducing and mixing EDTA 2Na.

[0053] Yet another embodiment provides a method for producing a cosmetic composition, comprising the step of adding a preservative for an external skin preparation.

[0054] Yet another embodiment provides a method for antibacterial, preservative or antiseptic treatment of a cosmetic composition, comprising the step of adding a preservative for external skin preparations.

[0055] In the above method, the mixing weight ratio or weight % of each component is as described above in the description of the preservative for external skin preparations.

[0056] In the above method, the specific conditions and methods are according to the ordinary techniques in the art, but are not limited thereto.

[0057] Of the terms or elements referred to in the method, those referred to in the description of the preservative for topical skin preparations or the cosmetic composition are understood to be the same as those referred to in the description of the preservative for topical skin preparations or the cosmetic composition described above.

[0058] Yet another embodiment provides the use of a composition comprising caprylhydroxamic acid, 4'-hydroxyacetophenone and caprylyl glycol for antibacterial, preservative or antiseptic treatment of an external skin preparation or cosmetic composition.

[0059] Yet another embodiment provides a use of a composition comprising caprylhydroxamic acid, 4'-hydroxyacetophenone and caprylyl glycol for producing a preservative for topical skin preparations, or a cosmetic composition for antibacterial or antiseptic purposes.

[0060] The composition may further comprise one or more polyols selected from the group consisting of glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, and alkanediols having 3 to 12 carbon atoms.

[0061] The composition may further comprise EDTA Disodium.

[0062] The mixing weight ratio or weight % of each of the components is as described above in the description of the preservative for external skin preparations.

[0063] Of the terms or elements referred to in the above uses, those referred to in the explanation of the preservative for topical skin preparations, cosmetic composition or method are understood to be the same as those referred to in the explanation of the preservative for topical skin preparations, cosmetic composition or method described above. Effect of the Invention

[0064] The preservative for topical skin preparations according to one embodiment exhibits excellent antibacterial or antiseptic effects against bacteria and fungi, and in particular, even when applied to a cosmetic composition containing a surfactant, the antibacterial or antiseptic effects against bacteria and fungi are not reduced, and the preservative effects are remarkably excellent. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0065] The present invention will be described in more detail below through examples and experimental examples. However, these examples and experimental examples are provided to illustratively explain the present invention, and the scope of the present invention is not limited to these examples and experimental examples.

[0066] 1. Production and evaluation of preservatives for topical skin preparations Examples 1 to 10: Production of preservatives for topical skin preparations In this example, a preservative for external skin preparations containing caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP), and caprylyl glycol was prepared.

[0067] Specifically, caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP), caprylyl glycol, and dipropylene glycol were mixed, and then heated to about 60 to 70°C while stirring to prepare preservatives for external use on the skin, and eight types of preservatives for external use on the skin (Examples 1 to 8) with different weight percentages of each mixed component were obtained. Disodium ethylenediaminetetraacetate (EDTA 2Na) was also added and mixed, and then heated to about 60 to 70°C while stirring to prepare preservatives for external use on the skin, and two types of preservatives for external use on the skin (Examples 9 to 10) with different weight percentages of each mixed component were obtained. Furthermore, three comparative examples (Comparative Examples 1 to 3) were prepared containing two components selected from caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP), and caprylyl glycol, and dipropylene glycol, and five comparative examples (Comparative Examples 4 to 8) were prepared containing caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP), caprylyl glycol, and dipropylene glycol, and the content of each component was different from that of the preservative for external skin preparation of the above examples. The comparative examples were prepared by the same method as the preparation method of the examples. The prepared examples 1 to 10 and comparative examples 1 to 8 are shown in Tables 1 and 2 below.

[0068] [Table 1]

[0069] [Table 2]

[0070] Experimental Example 1. Confirmation of the antibacterial effect of preservatives for topical skin preparations in the presence of cationic surfactants The antibacterial effect of the preservatives for external skin preparations prepared in Examples 1 to 10 was confirmed in the presence of a cationic surfactant. Coco-Betaine (CAS No. 68424-94-2), which is the most commonly used cationic surfactant in the cosmetics field, was used as the cationic surfactant.

[0071] Specifically, as shown in Tables 3 and 4 below, each of the preservatives for external skin preparations of Examples 1 to 10 was mixed with a cationic surfactant, and the mixture was examined for its antibacterial effect against bacteria, yeast, and mold. To examine the antibacterial effect against bacteria, culture solutions of Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), and Staphylococcus aureus (ATCC 6538) were mixed in a ratio of 1:1:1, and the mixed culture solutions were inoculated into the mixtures shown in Tables 3 and 4 below, respectively. At this time, the number of inoculated bacteria was about 10 6 To confirm the antibacterial effect against yeast, the culture solution of Candida albicans (ATCC 10231) was inoculated into the mixtures shown in Tables 3 and 4 below. The number of bacteria inoculated was about 10 5 To confirm the antibacterial effect against mold, the culture solution of Aspergillus brasiliensis (ATCC 16404) was inoculated into the mixtures shown in Tables 3 and 4 below. The number of bacteria inoculated was about 10 5 The samples were inoculated so that the CFU / g concentration was reached. After storage at room temperature (approximately 25°C) for 7 days after inoculation, the number of viable bacteria in each sample was measured, and the bacterial mortality rate (%) was finally analyzed. The results are shown in Table 5 below. The bacterial mortality rate (%) was calculated using the following formula:

[0072]

number

[0073] The mortality rate (%) was measured in an aqueous solution containing only a cationic surfactant at a concentration of about 30% without adding any of the preservatives for external skin preparations prepared in Examples 1 to 10 and Comparative Examples 1 to 8, and used as control group 1. In addition, the mortality rate (%) was measured in an aqueous solution containing only the preservative for external skin preparations prepared in Comparative Example 1 at a concentration of about 1% without adding any cationic surfactant, and used as control group 2. Furthermore, the mortality rate (%) was measured in a mixture obtained by mixing each of the preservatives for external skin preparations prepared in Comparative Examples 1 to 8 with a cationic surfactant, and used as control groups 3 to 10.

[0074] [Table 3]

[0075] [Table 4]

[0076] As a result, as shown in Table 5, when only a cationic surfactant was present (control group 1), the antibacterial effect against both bacteria and fungi (yeast and mold) was significantly low. In addition, in the case of Comparative Example 1 containing 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, it was confirmed that a certain level of antibacterial effect was exhibited in an environment without a surfactant (control group 2), but the antibacterial effect was significantly reduced in an environment with a cationic surfactant (control group 3). In addition, in the case of Examples 1 to 10 further containing caprylhydroxamic acid (CHA) in Comparative Example 1, it was confirmed that a killing effect of about 99% or more was exhibited against both bacteria and fungi (yeast and mold) even in an environment with a cationic surfactant (experimental groups 1 to 10), and a significantly excellent antibacterial effect was exhibited. In particular, among the examples, Examples 9 and 10, which further contained disodium ethylenediaminetetraacetate (EDTA 2Na), were confirmed to have the most excellent antibacterial effect, exhibiting approximately 99.99% killing effect against both bacteria and fungi (yeast and mold) even in an environment in which a cationic surfactant was present (Experimental Groups 9 and 10). Also, in the case of Comparative Examples 2 and 3, which contained caprylhydroxamic acid (CHA) but either 4'-hydroxyacetophenone (4'-HAP) or caprylyl glycol, it was confirmed that the antibacterial effect was significantly reduced in an environment in which a cationic surfactant was present (Control Groups 4 and 5), particularly the antibacterial effect against fungi (yeast and mold) was significantly reduced).

[0077] Furthermore, as shown in Table 5, it was confirmed that only when caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were contained in specific amounts, an excellent antibacterial effect was exhibited against both bacteria and fungi (yeast and mold) even in an environment in which a cationic surfactant was present. Specifically, it was confirmed that only the preservative for external skin preparations of the embodiment containing about 5 to 15% by weight of caprylhydroxamic acid (CHA), about 25 to 30% by weight of 4'-hydroxyacetophenone (4'-HAP) and about 13 to 15% by weight of caprylyl glycol exhibited an excellent antibacterial effect against both bacteria and fungi (yeast and mold) even in an environment in which a cationic surfactant was present. In addition, in the comparative examples in which the contents of caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were outside the above-mentioned ranges, it was confirmed that the antibacterial effect was significantly reduced in an environment in which a cationic surfactant was present (especially the antibacterial effect against fungi (yeast and mold) was significantly reduced).

[0078] [Table 5]

[0079] Experimental Example 2. Confirmation of the antibacterial effect of preservatives for topical skin preparations in the presence of nonionic surfactants The antibacterial effect of the preservatives for external skin preparations prepared in Examples 1 to 10 was confirmed in the presence of a nonionic surfactant. Lauryl glucoside, which is the most commonly used nonionic surfactant in the cosmetics field, was used as the nonionic surfactant.

[0080] Specifically, as shown in Tables 6 and 7 below, each of the preservatives for external skin preparations prepared in Examples 1 to 10 was mixed with a nonionic surfactant, and the antibacterial effect of the mixture against bacteria, yeast and mold was confirmed. The specific experimental method was the same as that performed in Experimental Example 1.

[0081] An aqueous solution containing only a nonionic surfactant at a concentration of about 30% without adding any of the preservatives for external skin preparations prepared in Examples 1 to 10 and Comparative Examples 1 to 8 was used as control group 11. Also, an aqueous solution containing only the preservative for external skin preparations prepared in Comparative Example 1 at a concentration of about 1% without adding any nonionic surfactant was used as control group 12. Furthermore, mixtures obtained by mixing each of the preservatives for external skin preparations prepared in Comparative Examples 1 to 8 with a nonionic surfactant were used as control groups 13 to 20.

[0082] [Table 6]

[0083] [Table 7]

[0084] As a result, as shown in Table 8, when only a nonionic surfactant was present (control group 11), the antibacterial effect against both bacteria and fungi (yeast and mold) was significantly low. In addition, in the case of Comparative Example 1 containing 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, it was confirmed that a certain level of antibacterial effect was exhibited in an environment without a surfactant (control group 12), but the antibacterial effect was significantly reduced in an environment with a nonionic surfactant (control group 13). In addition, in the case of Examples 1 to 10 further containing caprylhydroxamic acid (CHA) in Comparative Example 1, it was confirmed that a killing effect of about 99% or more was exhibited against both bacteria and fungi (yeast and mold) even in an environment with a nonionic surfactant (experimental groups 11 to 20), and a significantly excellent antibacterial effect was exhibited. In particular, among the examples, Examples 9 and 10, which further contained disodium ethylenediaminetetraacetate (EDTA 2Na), were confirmed to have the most excellent antibacterial effect, exhibiting approximately 99.99% killing effect against both bacteria and fungi (yeast and mold) even in the presence of a non-ionic surfactant (Experimental Groups 19 and 20). Also, Comparative Examples 2 and 3, which contain caprylhydroxamic acid (CHA) but either 4'-hydroxyacetophenone (4'-HAP) or caprylyl glycol, were confirmed to have a significantly reduced antibacterial effect (especially the antibacterial effect against fungi (yeast and mold) was significantly reduced) in the presence of a non-ionic surfactant (Control Groups 14 and 15).

[0085] Furthermore, as shown in Table 8, it was confirmed that only when caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were contained in specific amounts, an excellent antibacterial effect was exhibited against both bacteria and fungi (yeast and mold) even in an environment in which a nonionic surfactant was present. Specifically, it was confirmed that only the preservative for external skin preparations of the embodiment containing about 5 to 15% by weight of caprylhydroxamic acid (CHA), about 25 to 30% by weight of 4'-hydroxyacetophenone (4'-HAP) and about 13 to 15% by weight of caprylyl glycol exhibited an excellent antibacterial effect against both bacteria and fungi (yeast and mold) even in an environment in which a nonionic surfactant was present. In addition, in the comparative examples in which the contents of caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were outside the above-mentioned ranges, it was confirmed that the antibacterial effect was significantly reduced in an environment in which a nonionic surfactant was present (especially the antibacterial effect against fungi (yeast and mold) was significantly reduced).

[0086] [Table 8]

[0087] Experimental Example 3. Confirmation of the antibacterial effect of preservatives for topical skin preparations in the presence of an anionic surfactant The antibacterial effect of the preservatives for external skin preparations prepared in Examples 1 to 10 was confirmed in the presence of an anionic surfactant. Sodium laureth sulfate, which is the most commonly used anionic surfactant in the cosmetic field, was used as the anionic surfactant.

[0088] Specifically, as shown in Tables 9 and 10 below, each of the preservatives for external skin preparations prepared in Examples 1 to 10 was mixed with an anionic surfactant, and the antibacterial effect of the mixture against bacteria, yeast, and mold was confirmed. The specific experimental method was the same as that performed in Experimental Example 1.

[0089] An aqueous solution containing only an anionic surfactant at a concentration of about 30% without adding any of the preservatives for external skin preparations of Examples 1 to 10 and Comparative Examples 1 to 8 was used as control group 21. Also, an aqueous solution containing only the preservative for external skin preparations of Comparative Example 1 at a concentration of about 1% without adding any of the anionic surfactants was used as control group 22. Furthermore, mixtures obtained by mixing each of the preservatives for external skin preparations of Comparative Examples 1 to 8 with an anionic surfactant were used as control groups 23 to 30.

[0090] [Table 9]

[0091] [Table 10]

[0092] As a result, as shown in Table 11, when only an anionic surfactant was present (control group 21), the antibacterial effect against both bacteria and fungi (yeast and mold) was significantly low. In addition, in the case of Comparative Example 1 containing 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, it was confirmed that a certain level of antibacterial effect was exhibited in an environment without a surfactant (control group 22), but the antibacterial effect was significantly reduced in an environment with an anionic surfactant (control group 23). In contrast, in the case of Examples 1 to 10 further containing caprylhydroxamic acid (CHA) in Comparative Example 1, it was confirmed that even in an environment with an anionic surfactant (experimental groups 21 to 30), the antibacterial effect was significantly excellent, with a killing effect of about 99% or more against both bacteria and fungi (yeast and mold). In particular, among the examples, Examples 9 and 10, which further contained disodium ethylenediaminetetraacetate (EDTA 2Na), demonstrated the most excellent antibacterial effect, exhibiting approximately 99.99% killing effect against both bacteria and fungi (yeast and mold), even in an environment in which an anionic surfactant was present (Experimental Groups 29 to 30). Also, in the case of Comparative Examples 2 and 3, which contained caprylhydroxamic acid (CHA) but either 4'-hydroxyacetophenone (4'-HAP) or caprylyl glycol, it was confirmed that the antibacterial effect was significantly reduced in an environment in which an anionic surfactant was present (Control Groups 24 and 25).

[0093] Furthermore, as shown in Table 11, it was confirmed that only when caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were contained in specific amounts, an excellent antibacterial effect was exhibited against both bacteria and fungi (yeast and mold) even in an environment in which an anionic surfactant was present. Specifically, it was confirmed that only the preservative for external skin preparations of the embodiment containing about 5 to 15% by weight of caprylhydroxamic acid (CHA), about 25 to 30% by weight of 4'-hydroxyacetophenone (4'-HAP) and about 13 to 15% by weight of caprylyl glycol exhibited an excellent antibacterial effect against both bacteria and fungi (yeast and mold) even in an environment in which an anionic surfactant was present. In contrast, in the comparative example in which the contents of caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were outside the above ranges, it was confirmed that the antibacterial effect was significantly reduced in an environment in which an anionic surfactant was present.

[0094] [Table 11]

[0095] Experimental Example 4. Confirmation of the antibacterial effect of preservatives for topical skin preparations in the presence of amphoteric surfactants The antibacterial effect of the preservatives for external skin preparations prepared in Examples 1 to 10 was confirmed in the presence of an amphoteric surfactant. Cocamidopropyl betaine, which is the most commonly used amphoteric surfactant in the cosmetics field, was used as the amphoteric surfactant.

[0096] Specifically, as shown in Tables 12 and 13 below, each of the preservatives for external skin preparations prepared in Examples 1 to 10 was mixed with an amphoteric surfactant, and the antibacterial effect of the mixture against bacteria, yeast, and mold was confirmed. The specific experimental method was the same as that performed in Experimental Example 1.

[0097] An aqueous solution containing only an amphoteric surfactant at a concentration of about 30% without adding any of the preservatives for external skin preparations of Examples 1 to 10 and Comparative Examples 1 to 8 prepared above was used as control group 31. Also, an aqueous solution containing only the preservative for external skin preparations of Comparative Example 1 prepared above at a concentration of about 1% without adding any amphoteric surfactant was used as control group 32. Furthermore, mixtures obtained by mixing each of the preservatives for external skin preparations of Comparative Examples 1 to 8 prepared above with an amphoteric surfactant were used as control groups 33 to 40.

[0098] [Table 12]

[0099] [Table 13]

[0100] As a result, as shown in Table 14, when only an amphoteric surfactant was present (control group 31), the antibacterial effect against both bacteria and fungi (yeast and mold) was significantly low. In addition, in the case of Comparative Example 1 containing 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, it was confirmed that a certain level of antibacterial effect was exhibited in an environment in which no surfactant was present (control group 32), but the antibacterial effect was significantly reduced in an environment in which an amphoteric surfactant was present (control group 33). In addition, in the case of Examples 1 to 10 further containing caprylhydroxamic acid (CHA) in Comparative Example 1, it was confirmed that even in an environment in which an amphoteric surfactant was present (experimental groups 31 to 40), a killing effect of about 99% or more was exhibited against both bacteria and fungi (yeast and mold), and a significantly excellent antibacterial effect was exhibited. In particular, among the examples, Examples 9 and 10, which further contained disodium ethylenediaminetetraacetate (EDTA 2Na), were confirmed to have the most excellent antibacterial effect, exhibiting approximately 99.99% killing effect against both bacteria and fungi (yeast and mold) even in an environment in which an amphoteric surfactant was present (Experimental Groups 39 to 40). Also, in the case of Comparative Examples 2 and 3, which contained caprylhydroxamic acid (CHA) but either 4'-hydroxyacetophenone (4'-HAP) or caprylyl glycol, it was confirmed that the antibacterial effect was significantly reduced in an environment in which an amphoteric surfactant was present (Control Groups 34 and 35), particularly the antibacterial effect against fungi (yeast and mold) was significantly reduced.

[0101] Furthermore, as shown in Table 14, it was confirmed that only when caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were contained in specific amounts, an excellent antibacterial effect was exhibited against both bacteria and fungi (yeast and mold) even in an environment in which an amphoteric surfactant was present. Specifically, it was confirmed that only the preservative for external skin preparations of the embodiment containing about 5 to 15% by weight of caprylhydroxamic acid (CHA), about 25 to 30% by weight of 4'-hydroxyacetophenone (4'-HAP) and about 13 to 15% by weight of caprylyl glycol exhibited an excellent antibacterial effect against both bacteria and fungi (yeast and mold) even in an environment in which an amphoteric surfactant was present. In addition, in the comparative examples in which the contents of caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were outside the above-mentioned ranges, it was confirmed that the antibacterial effect was significantly reduced in an environment in which an amphoteric surfactant was present (especially the antibacterial effect against fungi (yeast and mold) was significantly reduced).

[0102] [Table 14]

[0103] 2. Production and evaluation of cosmetic compositions containing preservatives for topical skin preparations Examples 11 to 20: Preparation of cosmetic compositions containing preservatives for topical skin preparations In this example, a shampoo-type cosmetic composition was prepared containing the preservatives for external skin preparations of Examples 1 to 10, and further containing a surfactant and other cosmetic ingredients.

[0104] Specifically, each of the preservatives for external skin preparations of Examples 1 to 10 was mixed with a surfactant and other cosmetic raw materials and then stirred to obtain a cosmetic composition in shampoo form. The ingredients and weight percentages of the preservatives for external skin preparations, surfactants, and other cosmetic raw materials are shown in Table 15 below. In addition, as shown in Table 16 below, a cosmetic composition in shampoo form was prepared containing any one of the preservatives for external skin preparations of Comparative Examples 1 to 8, and further containing a surfactant and other cosmetic raw materials, and used as a comparison group.

[0105] [Table 15]

[0106] [Table 16]

[0107] Experimental Example 5. Confirmation of the preservative effect of a cosmetic composition containing a preservative for topical skin preparations In order to evaluate the preservative power of the preservatives for external skin preparations of Examples 1 to 10, a certain number of bacteria was inoculated into the cosmetic compositions in the form of shampoos of Examples 11 to 20, which are cosmetic compositions containing the preservatives for external skin preparations, and the number of surviving bacteria was counted. The cosmetic compositions of Comparative Examples 9 to 16 were used as comparative groups.

[0108] Specifically, the cosmetic compositions of Examples 11 to 20 and Comparative Examples 9 to 16 prepared above were inoculated with a bacterial culture, i.e., a mixed culture obtained by mixing Escherichia coli (ATCC 8739) culture, Pseudomonas aeruginosa (ATCC 9027) culture, and Staphylococcus aureus (ATCC 6538) culture in a ratio of 1:1:1. At this time, the initial concentration of bacteria per sample was about 10 6Thereafter, each sample was cultured in an incubator at about 25° C. for about 4 weeks, and about 1 g of each sample was taken at intervals of about 7 days to measure the number of viable bacteria.

[0109] In addition, the cosmetic compositions of Examples 11 to 20 and Comparative Examples 9 to 16 were each inoculated with a yeast culture solution, i.e., a Candida albicans (ATCC 10231) culture solution, so that the initial concentration of bacteria in each sample was about 10 5 After that, each sample was cultured in a thermostatic chamber at about 25° C. for about 4 weeks, and about 1 g of each sample was taken at intervals of about 7 days to measure the number of viable bacteria.

[0110] Furthermore, the cosmetic compositions of Examples 11 to 20 and Comparative Examples 9 to 16 were each inoculated with a mold culture solution, i.e., an Aspergillus brasiliensis (ATCC16404) culture solution, so that the initial concentration of bacteria in each sample was about 10 5 After that, each sample was cultured in a thermostatic chamber at about 25° C. for about 4 weeks, and about 1 g of each sample was taken at intervals of about 7 days to measure the number of viable bacteria.

[0111] As a result, as shown in Table 17, it was confirmed that the preservatives for external skin preparations of the Examples, which contain caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, exhibit excellent preservative effects against both bacteria and fungi (yeast and mold) in cosmetic composition formulations containing various surfactants. It was also confirmed that the preservatives for external skin preparations of Comparative Examples 1 to 3, which contain two selected from caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, exhibit significantly reduced preservative effects against bacteria and fungi (yeast and mold) (especially significantly reduced preservative effects against mold) in cosmetic composition formulations containing various surfactants.

[0112] Furthermore, as shown in Table 17, it was confirmed that only when caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol were contained in specific amounts, excellent preservative effects against both bacteria and fungi (yeast and mold) were exhibited in cosmetic compositions containing various surfactants. Specifically, it was confirmed that only the preservatives for external skin preparations of the Examples, which contain about 5 to 15% by weight of caprylhydroxamic acid (CHA), about 25 to 30% by weight of 4'-hydroxyacetophenone (4'-HAP) and about 13 to 15% by weight of caprylyl glycol, exhibited excellent preservative effects against both bacteria and fungi (yeast and mold) in cosmetic compositions containing various surfactants. In addition, it was confirmed that the preservatives for topical skin preparations of Comparative Examples 4 to 8, in which the contents of caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol are outside the above-mentioned numerical ranges, have a significantly reduced preservative effect against bacteria and fungi (yeast and mold) in cosmetic composition formulations containing various surfactants (in particular, the preservative effect against mold is significantly reduced).

[0113] [Table 17]

[0114] Through the above examples and experimental examples, it was confirmed that even in the case of a preservative for external skin preparations containing 4'-hydroxyacetophenone (4'-HAP), caprylyl glycol, and dipropylene glycol and exhibiting antibacterial effects, the antibacterial and antiseptic effects are significantly reduced in an environment in which a surfactant is present, and that the preservative for external skin preparations of the examples further contains caprylhydroxamic acid (CHA) to solve such problems, and that it exhibits excellent antibacterial and antiseptic effects against both bacteria and fungi (yeast and mold) even in cosmetic compositions containing various surfactants. In addition, it was confirmed that the preservative for external skin preparations of the examples further contains disodium ethylenediaminetetraacetate (EDTA 2Na) also exhibits the most excellent antibacterial and antiseptic effects against both bacteria and fungi (yeast and mold) even in cosmetic compositions containing various surfactants. In particular, it was confirmed that a preservative for topical skin preparations containing caprylhydroxamic acid (CHA) does not necessarily exhibit excellent antibacterial effects in cosmetic compositions containing surfactants, and that only the preservative for topical skin preparations in the examples, which contains all of the ingredients caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol, exhibits excellent antibacterial and preservative effects against both bacteria and fungi (yeast and mold), even in cosmetic compositions containing various surfactants.

[0115] Furthermore, through the above-mentioned Examples and Experimental Examples, it was confirmed that only the preservative for external skin preparations of the Examples, which contains about 5 to 15% by weight of caprylhydroxamic acid (CHA), about 25 to 30% by weight of 4'-hydroxyacetophenone (4'-HAP), and about 13 to 15% by weight of caprylyl glycol, exhibits excellent antibacterial and antiseptic effects against both bacteria and fungi (yeast and mold) in cosmetic compositions containing various surfactants, and that when the contents of caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP), and caprylyl glycol are out of the above numerical ranges, the antibacterial and antiseptic effects against bacteria and fungi (yeast and mold) are significantly reduced in cosmetic compositions containing various surfactants (especially the antibacterial and antiseptic effects against mold are significantly reduced).

[0116] Therefore, it has been confirmed that a preservative for topical skin preparations containing specific components and contents according to one embodiment can be used as a preservative, antiseptic, or antiseptic aid that can exhibit excellent antibacterial and antiseptic effects in cosmetic compositions containing various surfactants (e.g., cosmetic compositions for cleansing, etc.).

[0117] Although the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that such specific techniques are merely preferred embodiments and do not limit the scope of the present invention. Therefore, the substantial scope of the present invention is defined by the claims and their equivalents.

Claims

1. A preservative for topical skin preparations, comprising caprylhydroxamic acid (CHA), 4'-hydroxyacetophenone (4'-HAP) and caprylyl glycol.

2. The preservative for external skin preparations according to claim 1, further comprising one or more polyols selected from the group consisting of glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, and alkanediols having 3 to 12 carbon atoms.

3. 2. The preservative for external skin preparations according to claim 1, wherein the preservative for external skin preparations contains 5 to 15% by weight of the caprylhydroxamic acid based on the total weight of the preservative.

4. 2. The preservative for external skin preparations according to claim 1, wherein the preservative for external skin preparations contains 25 to 30% by weight of the 4'-hydroxyacetophenone based on the total weight of the preservative.

5. The preservative for external skin preparations according to claim 1 , wherein the preservative for external skin preparations contains 13 to 15% by weight of the caprylyl glycol based on the total weight of the preservative.

6. 2. The preservative for external skin preparations according to claim 1, wherein the weight ratio of said caprylhydroxamic acid, said 4'-hydroxyacetophenone and said caprylyl glycol is 5 to 15:25 to 30:13 to 15.

7. The preservative for external skin preparations according to claim 1 , further comprising disodium ethylenediaminetetraacetate (EDTA 2Na).

8. The preservative for an external preparation for skin according to claim 1 , wherein the external preparation for skin contains a surfactant.

9. The preservative for external skin preparations according to claim 8 , wherein the external skin preparation is a cleansing cosmetic composition.

10. A cosmetic composition comprising the preservative for external skin preparations according to claim 1 .

11. The cosmetic composition according to claim 10, further comprising a surfactant.

12. The cosmetic composition according to claim 11, wherein the cosmetic composition is a cleansing cosmetic composition.

13. The cosmetic composition according to claim 10, wherein the preservative for topical skin preparations is contained in an amount of 0.0001% to 50% by weight based on the total weight of the cosmetic composition.

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