Hair cleansing composition, method and use thereof

Abstract

The present disclosure provides a detoxified hair and scalp cleansing composition for washing and repairing hair. The detoxified hair and scalp cleansing composition described herein has a pH optimized for washing hair and the scalp. The pH of the detoxified hair and scalp cleansing composition minimizes and reduces swelling and protein loss. The detoxified hair and scalp cleansing composition described herein contains peptides based on the structure of keratin and keratin-related proteins. The peptides described bind to hair with high affinity and repair damage to keratin fibers by forming disulfide bonds and other binding interactions such as hydrogen bonds, ionic bonds, and van der Waals interactions.

Description

Technical Field

[0001] Cross-reference This application claims the benefit of U.S. Provisional Application No. 63 / 354,514, filed Jun. 22, 2022, which is hereby incorporated by reference in its entirety.

Background Art

[0002] Washing hair and the scalp is a common grooming practice that is considered important for optimal hair cleanliness, health, and maintenance. Hair cleansing agents typically remove sebum, sweat, exfoliated cutin, and environmental dirt and help prevent the onset of conditions such as folliculitis and seborrheic dermatitis. Currently commercially available formulations use synthetic detergents, technically referred to as "surfactant systems," formulated in various amounts and ratios to achieve a desired level of detergency. The beauty industry offers consumers numerous options for facilitating normal hair washing, including formulations containing a wide variety of ingredients and compositions.

[0003] In addition to removing sebum, sweat, exfoliated cutin, and environmental dirt, a secondary function of shampoo is to impart desired sensory effects to the hair. Hair that has been thoroughly washed, i.e., hair that is completely free of sebum and product, tends to have a feel that lacks smoothness and appears duller, and as a result is not typically considered cosmetically desirable. One strategy for addressing this problem is to incorporate a number of conditioners into the cleansing agent. These conditioners typically deposit on the hair surface and only modify the properties of the hair surface (improving the appearance and feel of the hair), and do not address fundamental damage to the hair structure. When these conditioning agents deposit excessively, especially in combination with insufficient washing, the conditioner can accumulate within the hair, weighing it down and making it appear duller. Accordingly, there is a need for a new hair cleansing agent composition that cleans the hair without excessive deposition of the conditioning agent and provides desired hair properties.

Summary of the Invention

[0004] In one aspect, the present disclosure provides a hair cleansing composition for cleansing and repairing hair. In some embodiments, the hair cleansing composition comprises one or more solvents, one or more peptides, one or more hair conditioners, one or more skin conditioners, one or more detergents, and one or more cosmetic or dermatologically acceptable excipients. In some embodiments, the one or more peptides comprise peptide sequences comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or combinations thereof. In some embodiments, the one or more peptides comprise peptide sequences comprising SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, or combinations thereof. In some embodiments, the one or more peptides comprise peptide sequences comprising SEQ ID NO: 400, SEQ ID NO: 409, SEQ ID NO: 412, or combinations thereof. In some embodiments, the one or more peptides comprise SEQ ID NO: 400. In some embodiments, the one or more peptides comprise SEQ ID NO: 409. In some embodiments, the one or more peptides comprise SEQ ID NO: 412.

[0005] In some embodiments, the concentration (% w / w) of the one or more peptides in the hair cleansing agent is from about 0.0001% to about 1%. In some embodiments, the concentration (% w / w) of the one or more peptides in the detoxifying hair and scalp cleansing agent is from about 0.0001% to about 0.01%. In some embodiments, the concentration (% w / w) of the one or more peptides in the detoxifying hair and scalp cleansing agent is from about 0.0001% to about 0.001%.

[0006] In some embodiments, the hair cleansing composition comprises one or more hair conditioners selected from panthenol, European raspberry leaf extract, safflower (Carthamus tinctorius) seed extract, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronic acid, or combinations thereof. In some embodiments, the hair cleansing composition comprises panthenol.

[0007] In some embodiments, the hair cleansing composition comprises one or more skin conditioners selected from caprylyl glycol, maltooligosyl glucoside, hydrolyzed hydrogenated starch, Opuntia ficus-indica stem extract, sugar isomerase, alpha-glucan oligosaccharide, Alteromonas fermentation extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or combinations thereof. In some embodiments, the detoxifying hair and scalp cleansing composition comprises one or more skin conditioners selected from caprylyl glycol and guar hydroxypropyltriammonium chloride. In some embodiments, one or more skin conditions comprise caprylyl glycol. In some embodiments, one or more skin conditions comprise guar hydroxypropyltriammonium chloride.

[0008] In some embodiments, the hair cleansing composition comprises one or more detergents. In some embodiments, one or more detergents are surfactants. In some embodiments, the surfactant is selected from anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, or combinations thereof.

[0009] In some embodiments, the surfactant is sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonic acid, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, olefin (C 14-16 ) sodium sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, sodium dioctyl sulfosuccinate, or at least one anionic surfactant selected from combinations thereof. In some embodiments, the at least one anionic surfactant comprises olefin (C 14-16 ) sodium sulfonate, sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, or combinations thereof. In some embodiments, the at least one anionic surfactant comprises olefin (C 14-16 ) sodium sulfonate. In some embodiments, the at least one anionic surfactant comprises sodium methyl 2-sulfolaurate. In some embodiments, the at least one anionic surfactant comprises sodium lauryl sulfoacetate.

[0010] In some embodiments, the surfactant comprises at least one amphoteric surfactant selected from cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, coco amphoacetate, coco amphodipropionate, disodium coco amphodiacetate, disodium coco amphodipropionate, lauro amphoacetate, sodium cocoyl isethionate, or combinations thereof. In some embodiments, the at least one amphoteric surfactant comprises cocamidopropyl betaine.

[0011] In some embodiments, the hair cleansing composition comprises one or more cosmetic or dermatologically acceptable excipients selected from humectants, chelating agents, buffering agents, or preservatives, or combinations thereof.

[0012] In some embodiments, the humectant is selected from glycerin, propylene glycol, propanediol, or isopentyldiol. In some embodiments, the humectant comprises glycerin.

[0013] In some embodiments, the chelating agent is selected from sodium phytate, EDTA, sodium gluconate, dicarboxymethylalanine trisodium, tetrasodium glutamate diacetate, or caprylic hydroxamic acid, or combinations thereof. In some embodiments, the chelating agent comprises caprylic hydroxamic acid, sodium phytate, or combinations thereof. In some embodiments, the chelating agent comprises caprylic hydroxamic acid. In some embodiments, the chelating agent comprises sodium phytate.

[0014] In some embodiments, the buffering agent is selected from citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or combinations thereof. In some embodiments, the buffering agent comprises citric acid.

[0015] In some embodiments, the preservative is selected from phenoxyethanol, caprylic hydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or combinations thereof. In some embodiments, the preservative comprises benzoic acid.

[0016] In some embodiments, the concentration (% w / w) of one or more solvents in the hair cleansing composition is from about 50% to about 90%. In some embodiments, the concentration (% w / w) of one or more hair conditioners in the hair cleansing composition is from about 0.01% to about 10%. In some embodiments, the concentration (% w / w) of one or more skin conditioners in the hair cleansing composition is from about 0.01% to about 5%. In some embodiments, the concentration (% w / w) of one or more detergents in the hair cleansing composition is from about 0.1% to about 20%. In some embodiments, the concentration (% w / w) of one or more cosmetic or dermatologically acceptable excipients in the hair cleansing composition is from about 0.1% to about 30%. In some embodiments, the one or more solvents include water.

[0017] In some embodiments, the pH of the hair cleansing composition is from about 4 to about 6. In some embodiments, the pH of the hair cleansing composition is about 4. In some embodiments, the pH of the hair cleansing composition is about 4.5. In some embodiments, the pH of the hair cleansing composition is about 5. In some embodiments, the pH of the hair cleansing composition is about 5.5. In some embodiments, the pH of the hair cleansing composition is about 6.

[0018] In another aspect, a method for cleansing hair using the hair cleansing composition described herein is provided.

[0019] Further aspects and advantages of the present disclosure will be readily apparent to those skilled in the art from the following detailed description, which shows and describes only exemplary embodiments of the present disclosure. As will be recognized, the present disclosure is capable of other embodiments and different embodiments, and some of the details thereof can be modified in various obvious respects without departing from the present disclosure.

DETAILED DESCRIPTION OF THE INVENTION

[0020] The fiber structure of human hair consists of the cuticle, cortex, and medulla. The cuticle consists of overlapping thin cell layers like a scale structure and protects the central part inside the hair known as the cortex. Cuticle cells are mechanically strong due to the high isodipeptide and disulfide bonds present in their individual lamellar layers and are resistant to many environmental factors such as the penetration of external molecules. The cuticle accounts for approximately 15% of the weight of a single hair. The cortex is the middle region of the hair and accounts for about 80% of the weight of a single hair. The cortex is composed of a hierarchical structure of elongated fibrous alpha-helical keratin that extends along the fiber axis embedded in an amorphous protein matrix. It is the cortex with a structure consisting of intertwined protein fibers and a supporting matrix that gives the hair its tensile properties (strength, stiffness). The cell membrane complex binds cuticle cells to other cuticle cells, cortex cells to other cortex cells, and cuticle and cortex cells. The medulla corresponds to a centrally located, thin cell-connected beam and is absent in some hair fibers.

[0021] Human hair contains approximately 65% - 95% protein. Proteins exhibit their active properties within a specific temperature and pH range, but can unfold beyond these limits. The thermal denaturation of fibrous hard alpha-keratin proteins, i.e., the cortex proteins involved in hair strength and stiffness, shows a significant increase in stability when treated with low pH solutions. This is particularly true for hair damaged by oxidation such as bleaching, and when quantified by DSC, it is proven by a significant increase in the enthalpy and peak temperature of thermal denaturation. Enthalpy is generally understood to reflect the amount and structural integrity of alpha-helical substances within the intermediate diameter filaments (IF) of hair, while the peak temperature reflects the cross-link density of the matrix in which the IF is embedded. This phenomenon is further supported by amino acid analysis, X-ray diffraction, Raman spectroscopy, and observation of tensile strength.

[0022] Alkaline pH creates a favorable environment for, among other things, the cleavage of cystine (disulfide), the hydrolysis of amide bonds, and the formation of lanthionine and lysinoalanine, all of which weaken the protein structure of hair. Although the thermal stability does not vary significantly depending on the time hair is exposed to a solution of a specific pH, when combined with the fact that the pH of tap water varies widely from neutral to alkaline, it is suggested that a negative effect can be experienced during the time hair is reasonably expected to be exposed during standard washing conditions.

[0023] Differences in the thermal stability of hair proteins exposed to different pHs have been observed, which are attributed to changes in the environment of the intermediate diameter filaments, i.e., the interface between the IF and the surrounding matrix proteins. The scaffold-like IF surface is created by side-chain interactions that anchor the filaments to the matrix. Strong adsorption of protons to the IF interface can help protect this interface, and in addition to disulfide bonds, the electrostatic force further stabilizes this region.

[0024] During washing, the hydrogen bonds that stabilize the protein structure by water molecules are broken in hair, so that it becomes structurally fragile. As a result, swelling occurs in specific parts of the cuticle, and the hair fiber becomes more susceptible to damage. Furthermore, it has been established that the swelling behavior of the hair cuticle strongly depends on pH, and the more alkaline the environment is, the greater the degree of swelling becomes. Apart from the influence on thermal stability, this modification due to the swelling of the cuticle by pH is closely related to the characteristics of hair and the tendency of damage directly related to consumers. When the cuticle swells, the friction force between hair fibers increases, resulting in an increase in tangling and a rough touch. Also, when hair is wet, it is in a fragile state, and in wet hair, the combination of an increased unnecessary combing force and a decreased breaking stress can easily lead to peeling of the cuticle, protein loss, and even serious split ends during hair washing or shampooing. The minimal swelling of the cuticle shown at an acidic pH can help offset this effect.

[0025] The proteins in hair are in an optimal state (structurally most elastic) around pH 5. Such a more acidic pH environment can also minimize excessive swelling of the cuticle, reduce protein loss, maintain hair color, and minimize electrostatic repulsion. This is also the ideal pH range for skin with an acidic mantle. Skin with a disrupted pH may experience barrier disruption, inflammation, and irritation. The pH of tap water varies significantly from 6.5 to 9.53 and may contain metal ions such as divalent calcium and magnesium (hard water minerals) that affect the texture of hair, as well as trace transition metals such as copper, iron, nickel, lead, and others that can contribute to the oxidative degradation of hair fibers.

[0026] Furthermore, the peptides can be used to treat hair damaged during washing. These peptides can interact with hair mainly through covalent (disulfide) bonds, polar bonds, and hydrophobic interactions. However, for the success of the treatment, it is necessary to penetrate the peptides into the cortex of the hair, but penetration can be difficult. Molecular size and polarity play a major role in determining the ability of a molecule to gain access to the inside of the fibrous structure. Furthermore, the presence of sebum or products on the hair hinders the ability of the peptides to move well into the cortex. As noted above, at an appropriate acidic pH, it helps to stabilize the protein structure of the hair, but these peptides can act complementarily and synergistically to provide further reinforcement. Taken together, this structure provides both protection and repair of the protein structure of the hair, which can become brittle during the washing process.

[0027] Accordingly, the present specification provides a hair cleansing composition having an optimized pH that reduces swelling and protein loss. By formulating the shampoo at a more acidic pH, this alkaline pH environment can be neutralized, which can help minimize the net negative charge of the hair protein, thereby minimizing cuticle swelling and reducing the binding sites for dissolved metal cations. The presence of protective agents such as skin softeners, occlusive agents, cationic agents, and polymers on the hair fiber minimizes friction and related styling damage and provides a barrier against heat, UV, and contaminants, but if the products accumulate excessively, the hair can be weighted down and inhibited, or additional products can similarly interfere with their function. The hair composition may include peptides that strengthen the protein structure within the hair cortex and restore the tensile strength of the hair fiber. These peptides may not be compatible with conventional conditioning agents that form a film or coating, which can prevent the peptides from interacting with the hair protein and, in particular, from entering the cortex.

[0028] In some embodiments, the hair cleansing composition described herein includes low molecular weight peptides that can penetrate the hair cortex and improve the mechanical properties of the hair. In some embodiments, the hair cleansing composition described herein provides a long-lasting improved texture and an improved coherence of the hair when dry. In combination, the hair cleansing composition described herein provides the hair with a soft, shiny, undamaged texture and other desired characteristics. The hair cleansing composition described herein reduces protein loss and repairs the underlying damage to the hair without removing any essential oils from the hair, thereby avoiding over-reliance on conditioners that coat the hair fibers to achieve the desired properties. Further, the hair cleansing composition described herein does not contribute to the excessive accumulation of conditioning agents or other products that can ultimately weigh down and suppress the hair, since their ingredients are limited.

[0029] In some embodiments, the hair cleansing composition provided herein includes one or more solvents, one or more peptides, one or more hair conditioners, one or more skin conditioners, one or more detergents, and one or more cosmetic or dermatologically acceptable excipients. In some embodiments, the one or more peptides have a peptide sequence of 6 to 15 amino acids. In some embodiments, 2 to 5 of the amino acids of the peptide sequence are cysteine. The peptide composition provides the hair with improved resistance, strength, toughness, and stiffness.

[0030] The hair cleansing composition described herein maintains an optimal pH environment for the hair to maintain its structural integrity while minimizing fiber swelling while cleansing the hair. In addition to this, the hair cleansing composition maintains an optimal pH environment to avoid excessive drying of the scalp while cleansing the scalp without disrupting the natural barrier function of the scalp. The hair cleansing composition described herein has a pH optimized for cleansing the hair and the scalp. In some embodiments, the pH of the hair cleansing composition is optimized to promote the effectiveness of certain components in the composition. In some embodiments, the pH of the hair cleansing composition is optimized to promote the effectiveness of salicylic acid. In some embodiments, the pH of the composition is optimized to promote the chelation of certain minerals and metals. In some embodiments, the pH of the composition is optimized to minimize cuticle swelling. In some embodiments, the reduction of cuticle swelling reduces hair tangling. In some embodiments, the pH of the composition is optimized to protect the structural integrity of the hair and reduce protein and lipid loss.

[0031] In some embodiments, the hair cleansing composition has a pH of from about 1 to about 7. In some embodiments, the hair cleansing composition has a pH of about 1, about 1.25, about 1.5, about 1.75, about 2, about 2.25, about 2.5, about 2.75, about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, and any value therebetween. In some embodiments, the hair cleansing composition has a pH of from about 1 to about 7, from about 2 to about 7, from about 3 to about 7, from about 3.5 to about 7, from about 4 to about 7, from about 4 to about 6.

[0032] Definitions Unless otherwise defined, all technical and scientific terms used herein, including all specialized terms, notations, and other terms, are intended to have the same meaning as commonly understood by one of ordinary skill in the art to which the claimed subject matter belongs. In some cases, terms with commonly understood meanings are defined herein for clarity and / or for ready reference, and the inclusion of such definitions herein should not necessarily be construed as indicating a substantial difference from what is commonly understood in the art.

[0033] Throughout this application, various embodiments may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of the present disclosure. Accordingly, a description of a range should be considered to specifically disclose all the possible sub-ranges and the individual numerical values within that range. For example, a description of a range such as 1 - 6 should be considered to specifically disclose sub-ranges such as 1 - 3, 1 - 4, 1 - 5, 2 - 4, 2 - 6, 3 - 6, etc., and the individual numbers within that range, such as 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range.

[0034] As used in this specification and the claims, the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise. For example, the term "sample" includes a plurality of samples and combinations thereof.

[0035] The terms "determining," "measuring," "evaluating," "assessing," "assaying," and "analyzing" are often used interchangeably herein to refer to forms of measurement. Such terms include determining whether an element is present (e.g., detecting). Such terms can include quantitative, qualitative, or both quantitative and qualitative determinations. An assessment can be relative or absolute. "Detecting the presence of" can include determining whether something is present or absent in a context, as well as determining the amount of something that is present.

[0036] As used herein when referring to a measurable value such as an amount or concentration, etc., the term "about" or "approximately" means encompassing a variation of 20%, 10%, 5%, 1%, 0.5%, or even 0.1% of the specified amount. For example, "about" can mean ±10% according to the convention in the art. Alternatively, "about" can mean a range of ±20%, ±10%, ±5%, or ±1% of a given value. Alternatively, especially with respect to biological systems or processes, this term can mean within a certain multiple of the value, up to 5-fold or up to 2-fold. If a particular value can be recited in the present application and claims, unless otherwise specified, the term "about" can be assumed to encompass up to the acceptable error range for the particular value. Also, if a range, sub-range, or both are presented, the range or sub-range can include the endpoints of the range or sub-range.

[0037] When a value is recited as a range, such disclosure is understood to include disclosure of all assumed sub-ranges within such range and specific numerical values falling within such range, whether or not specific numerical values or specific sub-ranges are explicitly recited.

[0038] The terms "comprise", "have", and "include" are open-ended conjunctive verbs. Any form or tense of one or more of these verbs, such as "comprises", "comprising", "has", "having", "includes", and "including", is also open-ended. For example, any method that "comprises", "has", or "includes" one or more steps is not limited to having only such one or more steps, but also encompasses other unlisted steps.

[0039] As used herein, the term "mixture" or "mixtures" means a simple combination of materials and any compounds that may result from such combination.

[0040] As used herein, the term "cosmetically acceptable" refers to such compounds, materials, compositions, and / or dosage forms that are suitable for use in contact with human and animal tissues without exhibiting excessive toxicity, irritation, allergic reactions, or other problems or complications within the scope of sound medical judgment and that are balanced with a reasonable benefit-risk ratio.

[0041] As used herein, the term "cosmetically or dermatologically acceptable" means that the described composition or component is suitable for use in contact with human skin tissue without exhibiting excessive toxicity, incompatibility, instability, allergic reactions, etc.

[0042] The headings of the chapters used herein are for organizational purposes only and should not be construed as limiting the subject matter described.

[0043] Peptide Washing with standard shampoos can result in the loss of keratin proteins. Furthermore, the pH of the hair during washing can further contribute to protein loss by causing swelling of the hair cuticle. In the present application, a hair cleansing composition is described that includes peptides based on the structure of keratin and keratin-related proteins. The peptides described herein bind to hair with high affinity and repair damage to keratin fibers by forming disulfide bonds. The peptides have sequences containing one or more cysteine amino acids that form disulfide bonds with free cysteine amino acids in hair or keratin and are involved in other types of binding interactions that stabilize the native proteins of hair. The formation of new peptide-protein bonds helps to restore the mechanical properties of hair fibers, including shine, resistance, and appearance.

[0044] In some embodiments, the peptides described herein have a low molecular weight of 6 to 15 amino acids and improve the ability to diffuse within the hair cortex, thereby reducing protein damage and loss during repeated washing and chemical treatments and improving the physical and mechanical properties of the hair fibers.

[0045] In some embodiments, the peptides described herein include hydrophobic residues to add hydrophobicity to the hair proteins and improve affinity. In some embodiments, the peptides described herein include polar residues to add hydrophilicity to the hair proteins and improve affinity.

[0046] In some embodiments, each of the peptide sequences described herein, as well as all or part of the peptide sequences, are used separately or in combination. In some embodiments, the hair cleansing composition includes at least one or more peptide sequences. In some embodiments, the hair cleansing composition includes at least two or more peptide sequences. In some embodiments, the hair cleansing composition includes at least three or more peptide sequences. In other embodiments, the hair cleansing composition includes at least four or more peptide sequences.

[0047] The number of amino acids in the peptide sequence is from 6 to 15. In some embodiments, the number of amino acids in the peptide sequence is 6. In some embodiments, the number of amino acids in the peptide sequence is 7. In some embodiments, the number of amino acids in the peptide sequence is 8. In some embodiments, the number of amino acids in the peptide sequence is 9. In some embodiments, the number of amino acids in the peptide sequence is 10. In some embodiments, the number of amino acids in the peptide sequence is 11. In some embodiments, the number of amino acids in the peptide sequence is 12. In some embodiments, the number of amino acids in the peptide sequence is 13. In some embodiments, the number of amino acids in the peptide sequence is 14. In some embodiments, the number of amino acids in the peptide sequence is 15.

[0048] In some embodiments, each peptide sequence contains an amino acid containing sulfur. In some embodiments, the peptide sequence contains cysteine amino acids that interact with hair and form intermolecular crosslinks to stabilize keratin fibers. In some embodiments, the hair cleansing composition described herein contains a peptide sequence with a high cysteine content for improving hair properties such as improving hair stiffness and resistance, reducing putative damage to hair, and improving and / or modifying hair characteristics. In some embodiments, cysteine constitutes 10% to 50% of the total amount of amino acids in the peptide sequence. In some embodiments, the peptide sequence contains 2 cysteines. In some embodiments, the peptide sequence contains 3 cysteines. In some embodiments, the peptide sequence contains 4 cysteines. In some embodiments, the peptide sequence contains 5 cysteines.

[0049] In some embodiments, the peptide comprises a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 951, SEQ ID NO: 1131, or a combination thereof. In some embodiments, the peptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 951, SEQ ID NO: 1131, or a combination thereof.

[0050]

Table 1

[0051] The concentration of the peptide used depends on several factors such as the condition of the hair, the origin of the hair, and the hair treatment formulation. The peptides described herein can be prepared by conventional peptide synthesis methods well known in the art. In some embodiments, the concentration (% w / w) of one or more peptides in the hair cleansing composition is from about 0.0001% to about 1.0%. In some embodiments, the concentration of the peptide in the hair cleansing composition is about 0.0001%, about 0.0005%, about 0.0010%, about 0.0015%, about 0.0020%, about 0.0025%, about 0.0030%, about 0.0035%, about 0.0040%, about 0.0045%, about 0.0050%, about 0.0055%, about 0.0060%, about 0.0065%, about 0.0070%, about 0.0075%, about 0.0080%, about 0.0085%, about 0.0090%, about 0.0095%, about 0.01%, about 0.05%, about 0.055%, about 0.060%, about 0.065%, about 0.070%, about 0.075%, about 0.080%, about 0.085%, about 0.090%, about 0.095%, about 0.1%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, and any value therebetween. In some embodiments, the concentration of the peptide in the hair cleansing composition is from about 0.0001% to about 0.95%, from about 0.0005% to about 0.9%, from about 0.001% to about 0.85%, from about 0.005% to about 0.8%, from about 0.010% to about 0.75%, from about 0.050% to about 0.70%, from about 0.10% to about 0.65%, from about 0.15% to about 0.60%, from about 0.20% to about 0.55%, from about 0.25% to about 0.50%, from about 0.30% to about 0.45%, from about 0.35% to about 0.40%, and from about 0.40% to about 1.0%.

[0052] The hair cleansing compositions described herein improve and enhance hair properties and characteristics such as body, strength, pH, structural integrity, appearance, and feel, and repair and / or protect damaged keratin fibers. The hair cleansing compositions described herein increase resistance due to the presence of cysteine-rich peptides in the composition even after several rinses. The hair cleansing compositions described herein function as effective detergents at an appropriate pH for the hair, without using excessive amounts of conditioning agents, and without exhibiting the associated irritation of other compositions in the art. In the context of the present disclosure, hair cleansing compositions can be applied to the hair as, but not limited to, aqueous solutions or conventional shampoos or conditioners.

[0053] Hair conditioner The hair cleansing compositions described herein include one or more hair conditioners that repair and improve hair properties such as body, resistance, texture (i.e., softness, smoothness, etc.), and appearance. In some embodiments, the hair cleansing composition is panthenol, salicylic acid, sodium salicylate, carnosine, tetrahexyldecyl ascorbate, hyaluronic acid / sodium hyaluronic acid, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA, brassidyl valinate, brassidyl isoleucinate, brassica alcohol, glycolipids, sphingoglycolipids, sphinganine, european raspberry leaf extract, bis-ethyl(isostearyl imidazoline) isostearamide, camellia sinensis leaf extract, carthamus tinctorius (safflower) seed extract, glycine max (soybean) seed extract, elaeis guineensis (palm) fruit extract, oryza sativa (rice) extract, hydrolyzed adansonia digitata seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropanediol ester, isoalkyl (C 10-40)One or more hair conditioners selected from amidopropyl ethyldimonium ethosulfate, extract of the plant Linum usitatisimum (flax), extract of Salvia hispanica seeds, extract of Astrocaryum murumuru fruit, extract of Moringa oleifera seeds, amidopropyltrimonium chloride caffeate, hydroxypropylgua-hydroxypropyltrimonium chloride, extract of Trifolium pratense (clover) flowers, extract of Opuntia ficus-indica stems, extract of Kappaphycus alvarezii, extract of Laminaria saccharina, guar hydroxypropyltrimonium chloride, bis-diglyceryl polyacyl adipate-2, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, biosaccharide gum-4, extract of Prunus Amygdalus dulcis (sweet almond) seeds, soy glycerides, Butyrospermum parkii (shea) butter ansaponifiable, hydrolyzed chestnut extract, glyceryl abietate, copolymer of methoxy PEG-16 sodium maleate / sodium styrene sulfonate, panthenyl hydroxypropyl stearodimonium chloride, and any combination thereof.

[0054] In some embodiments, the concentration (% w / w) of one or more hair conditioners in the hair cleansing composition is from about 0.01% to about 10.0%. In some embodiments, the concentration of one or more hair conditioners in the hair cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any value therebetween. In some embodiments, the concentration of one or more hair conditioners in the hair cleansing composition is from about 0.01% to about 10%, from about 0.05% to about 9.5%, from about 0.20% to about 9%, from about 0.30% to about 8.5%, from about 0.40% to about 8%, from about 0.50% to about 7.5%, from about 0.60% to about 7%, from about 0.70% to about 6.5%, from about 0.80% to about 6%, from about 0.90% to about 5.5%, and from about 1% to about 5%.

[0055] Skin conditioner The hair cleansing composition described herein includes one or more skin conditioners that help support the skin's barrier function and retain moisture. In some embodiments, the hair cleansing composition is niacinamide, allantoin, maltooligosyl glucoside, hydrolyzed hydrogenated starch, Opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba ester, hydrolyzed jojoba ester, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolate, nordihydroguaiaretic acid, ceramide, fructooligosaccharide, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, monosaccharide isomerase, Alteromonas fermentation extract, Pseudoalteromonas fermentation extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba sap, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis fruiting body extract, alpha-glucan oligosaccharide, and one or more skin conditioners selected from any combination thereof.

[0056] In some embodiments, the concentration (% w / w) of one or more skin conditioners in the hair cleansing composition is from about 0.01% to about 5.0%. In some embodiments, the concentration of one or more skin conditioners in the hair cleansing composition is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, and any value therebetween. In some embodiments, the concentration of one or more skin conditioners in the hair cleansing composition is from about 0.01% to about 0.95%, from about 0.05% to about 1.0%, from about 0.20% to about 0.90%, from about 0.30% to about 0.85%, from about 0.40% to about 0.80%, from about 0.50% to about 0.75%, from about 0.60% to about 0.70%, and from about 0.70% to about 1.0%.

[0057] Detergent The hair cleansing compositions described herein include one or more detergents that are useful for cleansing the hair but do not remove or replace any essential oils. In some embodiments, the hair cleansing composition includes one or more detergents selected from anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, and any combination thereof.

[0058] Surfactants, to be cosmetically acceptable, must in addition to being efficient detergents, provide a good foaming profile and a stable rheology. Anionic surfactants tend to be considered high performance in these areas, but consumer perception of the most efficient class conventionally used (i.e., sulfates) has made anionic surfactants difficult to accept. This restricts the selection of suitable surfactants, but it should also be noted that ionic tolerance is a further limiting factor, and as noted above, many surfactants tend to be neutral or alkaline, while acidic compositions require performance and stability at low pH and potentially in hard water. Sulfonates, particularly alkylsulfonates or olefin sulfonates, are one class of examples that meet certain criteria. These surfactants exhibit particularly good synergistic effects with alpha-hydroxy acids or salicylic acid.

[0059] However, single surfactant systems often lack one aspect or another, and it is preferable to utilize formulations. Amphoteric surfactants impart softness and improve the functional profile. Hydroxysultaine has a significantly low irritation profile, improving the mildness of surfactant formulations while enhancing foaming and stability and achieving lower total surfactant levels. This is another important criterion in formulations for protecting the skin barrier of the scalp. Hydroxysultaine also exhibits significantly broad pH and electrolyte tolerance and becomes an excellent detergent in combination with hard water and acidic components. Amino acid-derived surfactants can clean while moisturizing the skin or conditioning the hair and represent yet another exemplary option. These surfactants can be used daily on hair or skin when properly formulated. Finally, biosurfactants may be more sustainable raw materials and represent yet another type of high-performance detergent molecule that retains the further benefit of being environmentally compatible, having improved biodegradability, or being more environmentally friendly to manufacture.

[0060] In some embodiments, the one or more detergents are sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonic acid, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylene sulfonate, sodium olefin (C 14-16 ) sulfonate, sodium alpha olefin (C 14-16 ) sulfonate, disodium lauryl sulfosuccinate, sodium cocoyl methyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamate, lauroyl glutamate, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmoyl glutamate, sodium lauroyl lactate, sodium astrocaryum murumuru lipid fatty acid, sodium lauryl glucoside hydroxypropylsulfonate, disodium lauryl glucoside hydroxypropyl citrate, sodium hydroxypropylsulfonate / lauroyl glucoside copolymer, sodium dioctyl sulfosuccinate, and an anionic surfactant selected from any combination thereof.

[0061] In some embodiments, the one or more detergents are amphoteric surfactants selected from cocoamido propyl hydroxysultaine, cocoamidopropyl betaine, coco betaine, betaine, coco amphoacetate, coco amphodipropionate, disodium coco amphodiacetate, disodium coco amphodipropionate, lauryl betaine, lauroamidopropyl betaine, lauroamidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lysine dilauroyl glutamate, sodium coco amphopropionate, lauro amphoacetate, and any combination thereof.

[0062] In some embodiments, the one or more detergents are nonionic surfactants selected from decyl glucoside, lauryl glucoside, coconut oil glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocoamidopropyl amine oxide, decyl amine oxide, and combinations thereof.

[0063] In some embodiments, the one or more detergents are biosurfactants selected from Sapindus mukorossi (soapnut) extract, saponin, lipopeptide, canola sophorolipid, potassium cocooyl hydrolyzed wheat protein, fermentation product of Starmerella bombicola / Brassica oil, glycoside, glycolipid, rhamnolipid, phospholipid, sophorolipid, and any combination thereof.

[0064] In some embodiments, the concentration (% w / w) of one or more detergents in the hair cleansing composition is from about 0.1% to about 20%. In some embodiments, the concentration of one or more detergents in the hair cleansing composition is about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, 0.7%, about 0.8%, about 0.9%, about 1.0%, about 1.2%, about 1.4%, about 1.6%, about 1.8%, about 2.0%, about 2.5%, about 3.0%, about 3.5%, about 4.0%, about 4.5%, about 5.0%, about 5.5%, about 6.0%, about 6.5%, about 7.0%, about 7.5%, about 8.0%, about 8.5%, about 9.0%, about 9.5%, about 10.0%, about 10.5%, about 11.0%, about 11.5%, about 12.0%, about 12.5%, about 13%, about 13.5%, about 14%, about 14.5%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, and any value therebetween. In some embodiments, the concentration of one or more detergents in the hair cleansing composition is from about 0.1% to about 20%, from about 0.2% to about 19%, from about 0.3% to about 18%, from about 0.4% to about 17%, from about 0.5% to about 16%, from about 0.6% to about 15%, from about 0.7% to about 14.5%, from about 0.8% to about 14%, from about 0.9% to about 13.5%, from about 1.0% to about 13%, from about 1.5% to about 12.5%, from about 2.0% to about 12%, from about 2.5% to about 11.5%, from about 3.0% to about 11%, from about 3.5% to about 10.5%, and from about 4% to about 10%.

[0065] Excipient The hair cleansing composition described in this specification contains one or more cosmetic or dermatologically acceptable excipients. Cosmetic or dermatologically acceptable excipients include, but are not limited to, preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreens, vitamins, dyes, hair colorants, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, flavorings, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film-forming agents, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusters (buffers), neutralizing agents, buffers, hair conditioning agents, antistatic agents, anti-frizz agents, anti-dandruff agents, absorbents, and any combination thereof.

[0066] In some embodiments, the concentration (% w / w) of one or more cosmetic or dermatologically acceptable excipients in the hair cleansing composition is from about 0.1% to about 30%. In some embodiments, the concentration of one or more cosmetic or dermatologically acceptable excipients in the hair cleansing composition is about 0.1%, about 0.5%, about 1.0%, about 2.0%, about 3.0%, about 4.0%, about 5.0%, about 6.0%, about 7.0%, about 8.0%, about 9.0%, about 10.0%, about 11.0%, about 12.0%, about 13.0%, about 14.0%, about 15.0%, about 16.0%, about 17.0%, about 18.0%, about 19.0%, about 20.0%, about 21.0%, about 22.0%, about 23.0%, about 24.0%, about 25.0%, about 26.0%, about 27.0%, about 28.0%, about 29.0%, about 30.0%, and any value therebetween. In some embodiments, the concentration of one or more cosmetic or dermatologically acceptable excipients in the hair cleansing composition is from about 0.1% to about 29.0%, from about 0.5% to about 28.0%, from about 1.0% to about 27.0%, from about 2.0% to about 26.0%, from about 3.0% to about 25.0%, from about 4.0% to about 24.0%, from about 5.0% to about 23.0%, from about 6.0% to about 22.0%, from about 7.0% to about 21.0%, from about 8.0% to about 20.0%, from about 9.0% to about 19.0%, from about 10.0% to about 18.0%, from about 11.0% to about 17.0%, from about 12.0% to about 16.0%, from about 13.0% to about 15.0%, from about 14.0% to about 14.5%, and from about 14.5% to about 30.0%.

[0067] In some embodiments, one or more cosmetic or dermatologically acceptable excipients are capric / caprylic / diglycerol succinate, C 14-16 glycol palmitate, C 18-20 glycol isostearate, cocamidopropyl lauryl ether, dipentaerythrityl hydroxystearate, dipentaerythrityl hydroxystearate, dipentaerythrityl hexacaprylate / caprate, glyceryl palmit kernelate, lecithin, hydrogenated lecithin, phosphatidylcholine, C 12-16An emulsifier selected from alcohol, palmitic acid, glyceryl behenate, glyceryl stearate, glyceryl citrate stearate, glyceryl citrate oleate, sorbitan laurate, lauryl laurate, sorbitan olive oil fatty acid, cetearyl olive oil fatty acid, glyceryl citrate stearate, sodium stearoyl lactate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 coconut oil fatty acid, polyglyceryl-3 di(citrate / stearate), polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 capric acid, polyglyceryl-4 laurate, polyglyceryl-6 caprylic acid, polyglyceryl-6 stearic acid, polyglyceryl-6 distearate, polyglyceryl-6 behenic acid, polyglyceryl-6 polyhydroxystearic acid, polyglyceryl-6 oleic acid, polyglyceryl-6 ricinoleic acid, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, (candelilla / jojoba / rice bran) polyglyceryl-3 esters, stearoyl glutamate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylic acid, polyglyceryl-3 coconut oil fatty acid, polyglyceryl-4 capric acid, polyglyceryl-6 ricinoleic acid, polyglyceryl-6 caprylic acid, sodium surfactin, and any combination thereof.

[0068] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are chelating agents selected from phytic acid, sodium phytate, caprylic hydroxamic acid, alanine dicarboxymethyl trisodium, gluconic acid, sodium gluconate, pentetic acid pentasodium, carboxymethyl inulin sodium, glutamic acid diacetic acid tetrasodium, ethylenediamine disuccinic acid trisodium, sodium thiosulfate, diisopropyl oxalate, EDTA disodium, EDTA disodium-copper, HEDTA, oxalic acid, potassium citrate, sodium citrate, sodium oxalate, TEA-EDTA, EDTA tetrasodium, EDTA trisodium, HEDTA trisodium, and any combination thereof.

[0069] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are preservatives selected from benzoic acid, butylparaben, diazolidinyl urea, DMDM hydantoin, ethylparaben, imidazolidinyl urea, propyl iodide butylcarbamate, isobutylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propylparaben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, and any combination thereof.

[0070] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are lauryl lactate, hydroxypropyl starch phosphate, acrylate copolymer, acryloyldimethyltaurine ammonium, (acryloyldimethyltaurine sodium / VP) copolymer, (sodium acrylate / sodium acryloyldimethyltaurate) copolymer, sodium polyacrylate, polyacrylate crosspolymer-11, carbomer, (acrylates / alkyl acrylate (C 10-30)) a thickener selected from cross-polymers, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymers, sodium lithium magnesium silicate, fluosilicic acid (sodium / magnesium), glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, PEG-8 hydrogenated castor oil ester, and any combination thereof.

[0071] In some embodiments, one or more cosmetic or dermatologically acceptable excipients are antistatic agents. In some embodiments, the antistatic agent is a quaternary ammonium compound, behentrimonium chloride, behentrimonium methosulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, amido propyltrimonium chloride cinnamate, coco trimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, lauryltrimonium chloride, stearamidopropyl dimethylamine, stearyltrimonium chloride, stearalconium chloride, tricetyldimonium chloride, cocoyl arginine ethyl PCA, isoalkyl (C 10-40 ) amido propylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, cyanoacrylate amido propyltrimonium chloride, and a cationic surfactant selected from any combination thereof.

[0072] In some embodiments, one or more cosmetic or dermatologically acceptable excipients are natural - derived polymers selected from xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia senegal gum, cellulose, cellulose gum, carboxymethyl cellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, lauryl polyglucose, and any combination thereof.

[0073] In some embodiments, one or more cosmetic or dermatologically acceptable excipients are amino acids such as L - cysteine.

[0074] In some embodiments, one or more cosmetic or dermatologically acceptable excipients are humectants selected from 1,2,6 - hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyl diol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamide ethoxyethanol, and any combination thereof.

[0075] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are cationic polymers selected from polyquaternium-10, polyquaternium-7, polyquaternium-11, polyquaternium-57, quaternium-15, quaternium-18, quaternium-22, quaternium-87, guar hydroxypropyltrimonium chloride, and any combination thereof.

[0076] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are nonionic surfactants selected from decyl glucoside, lauryl glucoside, coconut oil glucoside, cocoyl methyl glucamide, capryloyl / caproyloyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof. In some embodiments, the nonionic surfactant is a solubilizer, emulsifier, stabilizer, emollient, thickener, and any combination thereof.

[0077] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are silicones selected from amodimethicone, amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilylamodimethicone, and any combination thereof

[0078] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are proteins selected from coco dimonium hydroxypropyl hydrolyzed casein, coco dimonium hydroxypropyl hydrolyzed collagen, coco dimonium hydroxypropyl hydrolyzed hair keratin, coco dimonium hydroxypropyl hydrolyzed keratin, coco dimonium hydroxypropyl hydrolyzed wheat protein, coco dimonium hydroxypropyl hydrolyzed silk, coco dimonium hydroxypropyl hydrolyzed soy protein, coco dimonium hydroxypropyl hydrolyzed wheat gluten, coco dimonium hydroxypropyl silk amino acids, coconut oil hydrolyzed collagen, coconut oil hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat gluten, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, palm oil fatty acid hydrolyzed collagen potassium, and any combination thereof.

[0079] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are vitamins selected from retinol, retinol palmitate, ascorbic acid, tocopherol, tocopherol acetate, and any combination thereof.

[0080] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are natural extracts selected from Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, Camellia sinensis leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, and combinations thereof.

[0081] In some embodiments, one or more cosmetic or dermatologically acceptable excipients are isopropyl lauroyl sarcosinate, phenethyl benzoate, C 12-15 alkyl benzoate, tri(caprylic / capric) glycerin, cetyl octanoate, octyldodecanol, (dilinoleic acid / propanediol) copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, (caproyl glycerin / sebacic acid) copolymer, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethylpiperidinyl dimethicone, (castor oil / IPDI) copolymer, coconut fatty acid butylene glycol, di(caprylic / capric) butylene glycol (dispersant), di(caprylic / capric) propylene glycol, triolein (algae oil), di(caprylic / capric) propylene glycol, lauroyl glutamate di(phytosteryl / octyldodecyl), tri-fatty acid (C 10-18 ) glycerin, isostearyl alcohol, diisostearyl malate, isoamyl laurate, *isoamyl coconut fatty acid, hemisqualane, polycitronellol acetate, ethyl macadamia nut fatty acid, (caprylic / capric) coconut alkyl, coconut alkane, (C 9-12 ) alkane, (C 13-15 ) alkane, (C 13-16)Isoalkane, Neopentyl Glycol Diheptanoate, Ethylhexyl Hydrogenated Olive Oil, Hydrogenated Olive Oil Unsaponifiables, Undecane, Tridecane, Isododecane, (Caprylic / Capric) Caprylyl, Cetyl Stearate, Cetearyl Stearate, Decyl Oleate, Glyceryl Stearate, Glyceryl Adipate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, (Caprylic / Capric) Glyceryl, (Citric / Lactic / Linoleic / Oleic) Glyceryl, Glyceryl Coconut Fatty Acids, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Diesterate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilaurate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Dilicinoleate, Glyceryl Distearate, Glyceryl Eluate, Glycol Stearate, Isocetyl Stearate, Isopropyl Myristate, Isopropyl Palmitate, Isopropyl Stearate, Isostearyl Stearate, Octyl Palmitate, Octyl Stearate, Di(Caprylic / Capric) Propylene Glycol, Sorbitan Benzoate, Sorbitan Caprylate, Sorbitan Isostearate, Sorbitan Laurate, Sorbitan Tristearate, Stearyl Stearate, Tocopherol Linoleate, Olive Oil, Avocado Oil, Coconut Oil, Sunflower Oil, Jojoba Oil, Argan Oil, Castor Oil, Almond Oil, Sesame (Sesamum indicum) Seed Oil, Prunus Armeniaca (Apricot) Kernel Oil, Crambe Abyssinica Seed Oil, Oryza Sativa (Rice) Bran Oil, Vitis Vinifera (Grape) Seed Oil, Passiflora Edulis Seed Oil, Meadowfoam Seed Oil, Butyrospermum Parkii (Shea) Butter, Shoreaa skin softening agent selected from shea butter, murumuru butter, and any combination thereof.

[0082] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are carnosine, ascorbyl tetrahexyldecyl, bioflavonoids, lycopene, carrot (daucus carota sativa) root cell culture lysate, monoammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), edelweiss (Leontopodium alpinum) extract, rosemary (Rosmarinus officinalis) leaf extract (WS), grape (Vitis vinifera) seed extract, green tea (Camellia sinensis) leaf extract, oak (Quercus robur) wood extract, hydrolyzed olive fruit, olive (Olea europea) leaf extract, oleuropein, pomegranate (Punica granatum) bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, and any combination thereof, an antioxidant.

[0083] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are a buffering agent selected from ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, and any combination thereof.

[0084] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are a salt selected from calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, and any combination thereof.

[0085] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are aliphatic alcohols selected from lauric acid, palmitic acid, stearic acid, arachidyl alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C 30-50 alcohol, lanolin alcohol, and any combination thereof.

[0086] In some embodiments, the one or more cosmetic or dermatologically acceptable excipients are fragrance components. In some embodiments, the fragrance component includes a fragrance. In some embodiments, the fragrance includes limonene.

[0087] Solvent The hair cleansing composition includes one or more solvents. In some embodiments, the one or more solvents are selected from water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, (dilinoleic acid / propanediol) copolymer, lower alcohols containing 1 to 6 carbon atoms such as ethanol, polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyl diol, polyethylene glycol such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose, and any combination thereof.

[0088] In some embodiments, the concentration (% w / w) of one or more solvents in the hair cleansing composition is from about 50% to about 90%. In some embodiments, the concentration of one or more solvents in the hair cleansing composition is about 50%, about 55%, about 60%, about 65%, 70%, about 75%, about 80%, about 85%, about 90%, and any value therebetween. In some embodiments, the concentration of one or more solvents in the hair cleansing composition is from about 50% to about 90%, from about 55% to about 85%, from about 60% to about 80%, from about 65% to about 80%, and from about 70% to about 80%.

[0089] Formulation In some embodiments, the hair cleansing composition comprises one or more solvents, one or more peptides, one or more hair conditioners, one or more skin conditioners, one or more detergents, and one or more cosmetic or dermatologically acceptable excipients and the one or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or a combination thereof.

[0090] In some embodiments, the hair cleansing composition comprises about 50% to about 90% (% w / w) of one or more solvents, about 0.0001% to about 1.0% (% w / w) of one or more peptides, about 0.01% to about 10.0% (% w / w) of one or more hair conditioners, about 0.01% to about 5.0% (% w / w) of one or more skin conditioners, about 0.1% to about 20% (% w / w) of one or more detergents, and about 0.1% to about 30% (% w / w) of one or more cosmetic or dermatologically acceptable excipients and One or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or a combination thereof.

[0091] In some embodiments, the hair cleansing composition comprises about 55% to about 85% (% w / w) of one or more solvents, about 0.0001% to about 0.9% (% w / w) of one or more peptides, about 0.20% to about 9% (% w / w) of one or more hair conditioners, about 0.01% to about 0.95% (% w / w) of one or more skin conditioners, about 0.3% to about 18% (% w / w) of one or more detergents, and about 0.5% to about 28.0% (% w / w) of one or more cosmetic or dermatologically acceptable excipients and One or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or a combination thereof.

[0092] In some embodiments, the hair cleansing composition comprises about 55% to about 85% (% w / w) of one or more solvents, about 0.0001% to about 0.9% (% w / w) of one or more peptides, about 0.20% to about 9% (% w / w) of one or more hair conditioners, about 0.01% to about 0.95% (% w / w) of one or more skin conditioners, about 0.3% to about 18% (% w / w) of one or more detergents selected from anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, and any combination thereof, and One or more cosmetically or dermatologically acceptable excipients selected from preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreens, vitamins, dyes, hair colorants, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, flavorings, oils, emollients, lubricants, butters, penetration enhancers, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film-forming agents, surfactants, detergents, emulsifiers, opacifying agents, volatile substances, propellants, liquid vehicles, carriers, salts, pH adjusters (buffers), neutralizing agents, buffers, hair conditioning agents, antistatic agents, anti-frizz agents, anti-dandruff agents, absorbents, and any combinations thereof in an amount of about 0.5% to about 28.0% (% w / w) comprising One or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or combinations thereof.

[0093] In some embodiments, the hair cleansing composition comprises from about 55% to about 85% (% w / w) of one or more solvents selected from water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, (dilinoleic acid / propanediol) copolymer, lower alcohols containing from 1 to 6 carbon atoms such as ethanol, polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyl diol, polyethylene glycol such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose, and any combinations thereof, from about 0.0001% to about 0.9% (% w / w) of one or more peptides, Panthenol, salicylic acid, sodium salicylate, carnosine, ascorbyl tetrahexyldecyl, hyaluronic acid / sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA, brassilvaline esylate, brassilisoleucine esylate, brassicalcohol, glycolipids, sphingoglycolipids, sphinganine, European raspberry leaf extract, bisethyl(isostearylimidazoline)isostearamide, Camellia sinensis leaf extract, Carthamus tinctorius (safflower) seed extract, Glycine soja (soybean) seed extract, Elaeis guineensis (palm) fruit extract, Oryza sativa (rice) extract, hydrolyzed baobab (adansonia digitata) seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropanediol ester, isoalkyl (C 10-40)One or more hair conditioners selected from amidopropyl ethyldimonium ethosulfate, Linum usitatisimum (flax) extract, Salvia hispanica seed extract, Astrocaryum murumuru fruit extract, Moringa oleifera seed extract, caffeic acid amidopropyltrimonium chloride, hydroxypropyl guar-hydroxypropyltrimonium chloride, Trifolium pratense (clover) flower extract, Opuntia ficus-indica stem extract, Kappaphycus alvarezii extract, Laminaria saccharina extract, guar hydroxypropyltriammonium chloride, bis-diglyceryl polyacyl adipate-2, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, biosaccharide gum-4, Prunus Amygdalus dulcis (sweet almond) seed extract, soy glycerides, Butyrospermum parkii (shea) butter ansaponifiable, hydrolyzed chestnut extract, glyceryl rosinate, copolymer of methoxy PEG-16 sodium maleate / sodium styrene sulfonate, panthenyl hydroxypropyl stearodimonium chloride, and any combination thereof in an amount of about 0.20% to about 9% (% w / w), Niacinamide, allantoin, malt oligosyl glucoside, hydrolyzed hydrogenated starch, Opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba ester, hydrolyzed jojoba ester, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolate, nordihydroguaiaretic acid, ceramide, fructooligosaccharide, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, monosaccharide isomerase, Alteromonas fermentation extract, Pseudoalteromonas fermentation extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba sap, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis fruiting body extract, alpha-glucan oligosaccharide, and one or more skin conditioners selected from any combination thereof in an amount of about 0.01% to about 0.95% (% w / w), One or more detergents selected from anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, and any combination thereof in an amount of about 0.3% to about 18% (% w / w), and One or more cosmetically or dermatologically acceptable excipients selected from preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreens, vitamins, dyes, hair colorants, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, flavorings, oils, emollients, lubricants, butters, penetration enhancers, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film-forming agents, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusters (buffers), neutralizing agents, buffers, hair conditioning agents, antistatic agents, anti-frizz agents, anti-dandruff agents, absorbents, and any combinations thereof, in an amount of about 0.5% to about 28.0% (% w / w) comprises One or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or combinations thereof.

[0094] In some embodiments, the hair cleansing composition comprises from about 55% to about 85% (% w / w) of one or more solvents selected from water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, (dilinoleic acid / propanediol) copolymer, lower alcohols containing from 1 to 6 carbon atoms such as ethanol, polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyl diol, polyethylene glycol such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose, and any combinations thereof, from about 0.0001% to about 0.9% (% w / w) of one or more peptides, Panthenol, salicylic acid, sodium salicylate, carnosine, ascorbyl tetrahexyldecyl, hyaluronic acid / sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA, brassicyl valinate esylate, brassicyl isoleucinate esylate, brassica alcohol, glycolipids, sphingoglycolipids, sphinganine, European raspberry leaf extract, bis-ethyl(isostearylimidazoline) isostearamide, Camellia sinensis leaf extract, safflower (Carthamus tinctorius) seed extract, glycine soja (soybean) seed extract, palm (Elaeis guineensis) fruit extract, Oryza sativa (rice) extract, hydrolyzed baobab (Adansonia digitata) seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropanediol ester, isoalkyl (C 10-40)One or more hair conditioners selected from amidopropyl ethyldimonium ethosulfate, Linum usitatisimum (flax) extract, Salvia hispanica seed extract, Astrocaryum murumuru fruit extract, Moringa oleifera seed extract, caffeic acid amidopropyltrimonium chloride, hydroxypropyl guar-hydroxypropyltrimonium chloride, Trifolium pratense (clover) flower extract, Opuntia ficus-indica stem extract, Kappaphycus alvarezii extract, Laminaria saccharina extract, guar hydroxypropyltriammonium chloride, bis-diglyceryl polyacyl adipate-2, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, biosaccharide gum-4, Prunus Amygdalus dulcis (sweet almond) seed extract, soy glycerides, Butyrospermum parkii (shea) butter ansaponifiable, hydrolyzed chestnut extract, glyceryl rosinate, copolymer of methoxy PEG-16 sodium maleate / sodium styrene sulfonate, panthenyl hydroxypropyl stearodimonium chloride, and any combination thereof in an amount of from about 0.20% to about 9% (% w / w), Niacinamide, allantoin, maltooligosyl glucoside, hydrolyzed hydrogenated starch, Opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba ester, hydrolyzed jojoba ester, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolate, nordihydroguaiaretic acid, ceramide, fructooligosaccharide, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, monosaccharide isomerase, Alteromonas fermentation extract, Pseudoalteromonas fermentation extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba sap, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis fruiting body extract, alpha-glucan oligosaccharide, and one or more skin conditioners selected from any combination thereof in an amount of about 0.01% to about 0.95% (% w / w), Sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonic acid, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium lauryl ether sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylene sulfonate, olefin (C 14-16 ) sulfonate sodium, alpha olefin (C 14-16)Sodium sulfonate, disodium lauryl sulfosuccinate, sodium cocoyl methyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamate, lauroyl glutamate, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmoyl glutamate, sodium lauroyl lactate, sodium astrocaryum murumuru lipid fatty acid, sodium lauryl glucoside hydroxypropyl sulfonate, disodium lauryl glucoside hydroxypropyl citrate, sodium hydroxypropyl sulfonate / lauryl glucoside copolymer, sodium dioctyl sulfosuccinate, cocoamido propyl hydroxysultaine, cocoamidopropyl betaine, coco betaine, betaine, coco amphoacetate, coco amphodipropionate, disodium coco amphodiacetate, disodium coco amphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauroyl glutamate lysine, sodium coco amphopropionate, lauro amphoacetate, decyl glucoside, lauryl glucoside, palm oil glucoside, cocoyl methyl glucamide, capryloyl / caproyloyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocoamidopropyl amine oxide, decyl amine oxide, Sapindus mukorossi (soap nuts) extract, saponin, lipopeptide, canolasophorolipid), hydrolyzed wheat gluten potassium cocoate, fermentation product of Starmerella bombicola / rapeseed oil, glycoside, glycolipid, rhamnolipid, phospholipid, sophorolipid, and a detergent selected from any combination thereof in an amount of about 0.3% to about 18% (% w / w), and caprylic / capric / diglycerol succinate, C 14-16 glycol palmitate, C 18-20 glycol isostearate, cocoamidopropyl lauryl ether, dipentaerythrityl hydroxystearate, dipentaerythrityl hydroxystearate, dipentaerythrityl hexacaprylate / caprate, glyceryl palm kernelate, lecithin, hydrogenated lecithin, phosphatidylcholine, C 12-16Alcohol, glyceryl palmitate, glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olive oil fatty acid, cetearyl olive oil fatty acid, glyceryl stearate citrate, sodium stearoyl lactate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 coconut oil fatty acid, polyglyceryl-3 di(citrate / stearate), polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprylate, polyglyceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, (candelilla / jojoba / rice bran) polyglyceryl-3 esters, stearoyl glutamate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 coconut oil fatty acid, polyglyceryl-4 caprylate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, phytic acid, sodium phytate, caprylic hydroxamic acid, trinatrium alaninedicarboxymethyl, gluconic acid, sodium gluconate, pentasodium pentetate, sodium carboxymethyl inulin, tetrasodium glutamate diacetate, trisodium ethylenediamine disuccinate, sodium thiosulfate, diisopropyl oxalate, disodium EDTA, disodium EDTA-copper, HEDTA, oxalic acid, potassium citrate, sodium citrate, dodium oxalateoxalate), TEA-EDTA, EDTA tetrasodium, EDTA trisodium, HEDTA trisodium, benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, propyl iodide butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexyl glycerin, gluconolactone, lauryl lactate, hydroxypropyl starch phosphate, acrylate copolymer, acryloyldimethyltaurine ammonium, (acryloyldimethyltaurine sodium / VP) copolymer, (sodium acrylate / sodium acryloyldimethyltaurine) copolymer, sodium polyacrylate, polyacrylate cross polymer-11, carbomer, (acrylates / alkyl acrylate (C 10-30 )) cross polymer, (hydroxyethyl acrylate / sodium acryloyldimethyltaurine) copolymer, sodium lithium magnesium silicate, fluosilicic acid (sodium / magnesium), glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, PEG-8 hydrogenated castor oil ester, quaternary ammonium compound, behentrimonium chloride, behentrimonium methosulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, amido propyltrimonium chloride cinnamate, coco trimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, lauryltrimonium chloride, stearamidopropyldimethylamine, stearyltrimonium chloride, stearalconium chloride, tricetyldimonium chloride, cocooyl arginine ethyl PCA, isoalkyl (C 10-40Amidopropyl ethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, cetyldimonium chloride, xanthan gum, pullulan, algin, cluster bean (tetragonoloba) gum, sclerotium gum, acacia senegal gum, cellulose, cellulose gum, carboxymethyl cellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, lauryl polyglucose, L-cysteine, 1,2,6-hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyl diol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamide ethoxyethanol, polyquaternium-10, polyquaternium-7, polyquaternium-11, polyquaternium-57, quaternium-15, quaternium-18, quaternium-22, quaternium-87, guar hydroxypropyltrimonium chloride, decyl glucoside, lauryl glucoside, coconut oil glucoside, cocoyl methyl glucamide, capryloyl / caproyloyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, amodimethicone, amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilylamodimethicone, cocodimonium hydroxypropyl hydrolyzed casein,Cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soybean protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocooyl hydrolyzed collagen, cocooyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soybean protein, hydrolyzed wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, palm oil fatty acid hydrolyzed collagen potassium, retinol, retinol palmitate, ascorbic acid, tocopherol, tocopherol acetate ester, Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, Camellia sinensis leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, lauroyl sarcosine isopropyl, phenethyl benzoate, C, 12-15Alkyl benzoate, Tri(caprylic / capric acid) glyceryl, Cetyl octanoate, Octyldodecanol, (Dilinoleic acid / propanediol) copolymer, Isoamyl laurate, Oleic acid, Isohexadecane, Squalane, Isopropyl palmitate, Polycitronellol, Diheptyl succinate, (Caproyl glycerin / sebacic acid) copolymer, PPG-3 benzyl ether ethylhexanoate, Hydrogenated vegetable oil, Triheptanoin, Diisopropyl sebacate, Diisopropyl adipate, Propylene glycol dibenzoate, Propoxytetramethylpiperidinyl dimethicone, (Castor oil / IPDI) copolymer, Coconut oil fatty acid butylene glycol, Di(caprylic / capric acid) butylene glycol (dispersant), Di(caprylic / capric acid) propylene glycol, Triolein (algal oil), Di(caprylic / capric acid) propylene glycol, Lauroyl glutamate di(phytosteryl / octyldodecyl), Tri-fatty acid (C 10-18 ) glyceryl, Isostearyl alcohol, Diisostearyl malate, Isoamyl laurate, *Isoamyl coconut oil fatty acid, Hemisqualane, Polycitronellol acetate, Ethyl macadamia nut fatty acid, (Caprylic / capric acid) coconut alkyl, Coconut alkane, (C 9-12 ) alkane, (C 13-15 ) alkane, (C 13-16)Isoparaffin, Neopentyl Glycol Diheptanoate, Ethylhexyl Hydrogenated Olive Oil, Hydrogenated Olive Oil Unsaponifiables, Undecane, Tridecane, Isododecane, (Caprylic / Capric) Caprylyl, Cetyl Stearate, Cetearyl Stearate, Decyl Oleate, Glyceryl Stearate, Glyceryl Adipate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, (Caprylic / Capric) Glyceryl, (Citric / Lactic / Linoleic / Oleic) Glyceryl, Glyceryl Coconut Fatty Acids, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dielaidate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilaurate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Dilinolenate, Glyceryl Distearate, Glyceryl Elaidate, Glycol Stearate, Isocetyl Stearate, Isopropyl Myristate, Isopropyl Palmitate, Isopropyl Stearate, Isostearyl Stearate, Octyl Palmitate, Octyl Stearate, Di(Caprylic / Capric) Propylene Glycol, Sorbitan Benzoate, Sorbitan Caprylate, Sorbitan Isostearate, Sorbitan Laurate, Sorbitan Tristearate, Stearyl Stearate, Tocopherol Linoleate, Olive Oil, Avocado Oil, Coconut Oil, Sunflower Oil, Jojoba Oil, Argan Oil, Castor Oil, Almond Oil, Sesamum indicum (Sesame) Seed Oil, Prunus Armeniaca (Apricot) Kernel Oil, Cranberry Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Butyrospermum parkii (shea) butter, Shorea robusta seed butter, murumuru butter, carnosine, ascorbyl tetrahexyldecyl, bioflavonoid, lycopene, Daucus carota sativa root cell lysate, glycyrrhizic acid monoammonium, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europaea (olive) leaf extract, oleuropein, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenol, epigallocatechin (EGCG), tannin, sulforaphane, resveratrol, nordihydroguaiaretic acid, ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, lauric acid, palmitic acid, stearic acid, arachidyl alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C 30-50One or more cosmetic or dermatologically acceptable excipients selected from alcohol, lanolin alcohol, and any combination thereof, in an amount of about 0.5% to about 28.0% (% w / w) comprising One or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or a combination thereof.

Example

[0095] The following examples are included for illustrative purposes only and are not intended to limit the scope of the invention.

[0096] Example 1. Preparation of Hair Shampoo Exemplary hair shampoo compositions are presented in Tables 2 to 6. The exemplary hair shampoo compositions are produced by conventional compounding and mixing techniques or by mixing one or more polyols (such as glycerin), water, and a surfactant with any solid that needs to be heated and melted at a high temperature. These components are thoroughly mixed at a high temperature and then cooled to ambient temperature. Further components are added to the cooled product. Unless otherwise specified, the amounts described are intended to reflect the weight percentages of the active materials.

[0097]

Table 2

[0098]

Table 3

[0099]

Table 4

[0100]

Table 5

[0101]

Table 6

[0102] Example 2. Evaluation of the Efficacy of Hair Shampoo During and After Washing A hair shampoo composition is prepared according to Example 1. The hair shampoo composition is evaluated using an investigation for determining the sensory effects of the hair shampoo on gloss, texture (i.e., slipperiness), stiffness, and firmness. The sensory effects are evaluated during washing and after drying.

[0103] Gently rinse a human hair bundle with a length of 25 cm, a width of 5.5 cm, and a weight of 10 g in warm water at 40°C. Remove excess water, and thoroughly lather the hair bundle for about 1 minute using 1.5 g of the hair shampoo composition per 10 g of the hair bundle. Conduct a sensory evaluation on the lathered hair and determine its slipperiness. The evaluation is performed by 20 people, and the total value of the evaluation is shown. The evaluation criteria are 4: glide well, 3: glide slightly, 2: do not glide well, and 1: do not glide.

[0104] Gently rinse a human hair bundle with a length of 25 cm, a width of 5.5 cm, and a weight of 10 g in warm water at 40°C. Remove excess water, and thoroughly lather the hair bundle for about 1 minute using 1.5 g of the hair shampoo composition per 10 g of the hair bundle. Rinse the lathered hair with running water at 40°C (2 L / min) for 1 minute. Remove excess moisture using a towel and air-dry the hair bundle. After drying, conduct a sensory evaluation on the dried hair and determine its gloss and coherence. The evaluation is performed by 20 people, and the total value of the evaluation is shown. The evaluation criteria are 4: good, 3: slightly good, 2: not very good, and 1: not good.

[0105] Thoroughly rinse a human hair bundle with a length of 25 cm, a width of 5.5 cm, and a weight of 10 g in warm water at 40°C. Thoroughly lather the hair bundle for about 1 minute using 5 g or 10 g of a hair cleansing composition. Thoroughly rinse the lathered hair with running water at 40°C (2 L / min). Remove excess moisture using a towel and dry the hair bundle with warm air from a hair dryer. After drying, perform a sensory evaluation on the dried hair to determine its stiffness. The evaluation is conducted by 25 people and shows the total value of the evaluation. The evaluation criteria are as follows: 4: A significant improvement in stiffness is observed; 3: An improvement in stiffness and firmness is observed; 2: A slight improvement in stiffness is observed; 1: No improvement in stiffness; and 0: Stiffness disappears.

[0106] Example 3. Evaluation of the effectiveness of a cleansing agent using FTIR Samples of bleached hair may be collected. A part of the sample of bleached hair may be treated with the hair cleansing composition described in this specification. For both the treated sample and the untreated sample, prepare cross-sections using a cryostat and examine the cross-sections using attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Use this technique to generate hyperspectral images and use these to visualize the lipid content inside the hair fiber, assess the hair damage (i.e., chemical treatment or UV exposure) inside the hair fiber, identify the modification of the hair structure (i.e., the three-dimensional structure of proteins or the organization of lipids), evaluate the hair moisture (i.e., the water content), visualize the active penetration inside the hair fiber, and determine the effectiveness of the cleansing agent for removing sebum and products from the hair.

[0107] Both single fibers of the treated sample and the untreated sample may be scanned longitudinally using ATR-FTIR, which can provide infrared images of approximately 1 to 2 microns outside the fiber surface. Using these hyperspectral images, determine the lipid content in the cuticle, examine the hair damage (i.e., chemical treatment or UV exposure) along the fiber, analyze the deposition of active ingredients along the hair fiber, identify the modification of the hair structure (i.e., the three-dimensional structure of proteins or the organization of lipids), evaluate the hair moisture (i.e., the water content), and determine the effectiveness of the cleansing agent for removing sebum and products from the hair.

[0108] Example 4: Evaluation of Metal Reduction / Chelation A sample of bleached hair may be taken. A part of the sample of bleached hair may be treated with the hair cleansing composition described herein. Both the treated sample and the untreated sample may be rinsed with hard water and examined using time-of-flight secondary ion mass spectrometry (TOF-SIMS). Spectra for calcium, magnesium, copper, aluminum, iron, chromium, zinc, nickel, cadmium, lead, and mercury may be obtained. ***

[0109] Although the preferred embodiments of the present invention have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. It is not intended that the present invention be limited by the specific examples provided within the specification. The present invention has been described with reference to the foregoing specification, but the description and illustration of the embodiments herein are not meant to be construed in a limiting sense. Many variations, modifications, and substitutions will occur to those skilled in the art without departing from the present invention. Furthermore, it will be understood that all aspects of the present invention are not limited to the specific depictions, configurations, or relative ratios described herein, which depend on various conditions and variables. It should be understood that various alternatives to the embodiments of the present invention described herein may be utilized in practicing the present invention. Therefore, the present invention is intended to cover any such alternatives, modifications, variations, or equivalents. The following claims define the scope of the present invention, and it is intended that methods and structures within the scope of these claims and their equivalents be covered thereby.

Claims

1. A hair cleaning agent, one or more solvents, one or more peptides, one or more hair conditioners, one or more skin conditioners, one or more cleaning agents, and one or more cosmetic or dermatologically acceptable excipients comprising, wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or a combination thereof, a hair cleaning agent.

2. The concentration (% w / w) of the one or more peptides in the hair cleaning agent is from about 0.0001% to about 1%, the hair cleaning agent according to claim 1.

3. The one or more hair conditioners are selected from the group consisting of panthenol, Rubus idaeus leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination thereof, the hair cleaning agent according to claim 1.

4. The one or more skin conditioners are selected from the group consisting of caprylyl glycol, maltooligosyl glucoside, hydrolyzed hydrogenated starch, Opuntia ficus-indica stem extract, sugar isomerase, alpha-glucan oligosaccharide, Alteromonas fermentation extract, Anetholea anisata leaf extract, guar hydroxypropyltrimonium chloride, or a combination thereof, the hair cleaning agent according to claim 1.

5. The one or more cleaning agents are surfactants, the hair cleaning agent according to claim 1.

6. The surfactant is selected from the group consisting of anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, or a combination thereof, the hair cleaning agent according to claim 5.

7. The surfactant is sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonic acid, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, olefin (C １４－１６ ) sodium sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, sodium dioctyl sulfosuccinate, or at least one anionic surfactant selected from the group consisting of combinations thereof, the hair cleaning agent according to claim 6.

8. The hair cleansing agent according to claim 6, wherein the surfactant comprises at least one amphoteric surfactant selected from the group consisting of cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, coco amphoacetate, coco amphodipropionate, coco amphodiacetate disodium, coco amphodipropionate disodium, lauro amphoacetate, sodium cocoyl isethionate, or combinations thereof.

9. The hair cleansing agent according to claim 1, wherein the one or more cosmetic or dermatologically acceptable excipients are selected from the group consisting of a humectant, a chelating agent, a buffering agent, or a preservative, or combinations thereof.

10. The hair cleansing agent according to claim 9, wherein the humectant is selected from the group consisting of glycerin, propylene glycol, propanediol, or isopentyldiol.

11. The hair cleansing agent according to claim 9, wherein the chelating agent is selected from the group consisting of sodium phytate, EDTA, sodium gluconate, disodium alanine dicarboxymethyl tri-sodium, tetrasodium glutamate diacetate, or caprylic hydroxamic acid, or combinations thereof.

12. The hair cleansing agent according to claim 9, wherein the buffering agent is selected from the group consisting of citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L - arginine, sodium hydroxide, potassium hydroxide, or combinations thereof.

13. The hair cleansing agent according to claim 9, wherein the preservative is selected from the group consisting of phenoxyethanol, caprylic hydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or combinations thereof.

14. The hair cleansing agent according to any one of claims 1 to 13, wherein the concentration (% w / w) of the one or more solvents in the hair cleansing agent is from about 50% to about 90%.

15. The hair cleansing agent according to any one of claims 1 to 14, wherein the concentration (% w / w) of the one or more hair conditioners in the hair cleansing agent is from about 0.01% to about 10%.

16. The hair cleansing agent according to any one of claims 1 to 15, wherein the concentration (% w / w) of the one or more skin conditioners in the hair cleansing agent is from about 0.01% to about 5%.

17. The concentration (% w / w) of the one or more detergents in the hair detergent is from about 0.1% to about 20%, the hair detergent according to any one of claims 1 to 16.

18. The concentration (% w / w) of the one or more cosmetic or dermatologically acceptable excipients in the hair detergent is from about 0.1% to about 30%, the hair detergent according to any one of claims 1 to 17.

19. The pH of the hair detergent is from about 4 to about 6, the hair detergent according to any one of claims 1 to 18.

20. A method for washing hair using the hair detergent according to any one of claims 1 to 19.

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