A composition comprising a self-tanning agent and a specific sphingolipid and / or a specific sphingoid base

Abstract

The present invention relates to a composition comprising at least one self-tanning agent and a specific sphingolipid and / or a specific sphingoid base.

Description

Technical Field

[0001] The present invention relates to a composition comprising at least one self-tanning agent and a specific sphingolipid and / or a specific sphingoid base.

Background Art

[0002] Ceramide itself has been used in the cosmetic field for decades.

[0003] Products containing ceramide NP (Cermide III, N-oleoyl-phytosphingosine) and a self-tanning agent are on the market.

[0004] However, so far, the special effects in the field of skin sunburn are not attributable to the class of ceramides.

[0005] An object of the present invention is to provide a substance that enhances the self-tanning effect in cosmetics.

[0006] <Mode for Carrying Out the Invention> Surprisingly, it has been found that specific sphingolipids and specific sphingoid bases can boost the tanning effect of self-tanning agents.

[0007] Therefore, the present invention provides the composition according to claim 1.

[0008] The present invention further provides the new sphingolipid according to claim 8.

[0009] One advantage of the present invention is that sphingolipids can improve the tanning effect of self-tanning agents without inducing the generally known UV damage response caused by sunlight exposure of the skin.

[0010] As a further benefit, the barrier is strengthened by the application of sphingolipids.

[0011] Another advantage of the present invention is that by adding sphingolipids to the self-tanning agent, the adverse effects of these molecular classes are reduced. As an example, DHA is known to form formaldehyde in the skin after application. By adding sphingolipids, the concentration of self-tanning molecules such as DHA can be significantly reduced, and side effects can be minimized.

[0012] A further advantage is that, as is known for classical self-tanning molecules, the addition of sphingolipids results in a more uniform skin tone and less yellowing.

[0013] Furthermore, the self-tanning effect lasts longer. Sphingolipids are very effective active ingredients that already act at low concentrations.

[0014] Another advantage is better formulation stability due to the ability of sphingolipids to build a lamellar phase that can help stabilize classical self-tanning molecules.

[0015] Another advantage of the present invention is that sphingolipids, in particular the structure according to claim 8, strengthen, regulate and balance the skin microbiome that contributes to a strong skin barrier and overall healthy skin in the case of long-term sunburn.

[0016] Thus, the present invention provides A) at least one self-tanning agent, and B) at least one sphingolipid of general formula I,

Chemical formula

[0017] The sphingolipid of general formula I has a plurality of stereocenters, all of which are included in general formula I.

[0018] Unless otherwise specified, all given percentages (%) are by mass.

[0019] A preferred composition according to the present invention is characterized in that at least one self-tanning agent is selected from the group consisting of dihydroxyacetone and erythrulose.

[0020] A preferred composition according to the present invention is such that the sphingolipid of general formula I is wherein R 1 is H, X is CH2-HCOH, n is an integer of 6 to 7, most preferably selected from 6, and is selected from sphingolipids.

[0021] A preferred composition according to the present invention is characterized in that A) is contained in an amount of 0.02% to 1.50% by weight, preferably 0.03% to 1.00% by weight, more preferably 0.05% to 0.50% by weight, and the weight percentage is based on the total composition.

[0022] A preferred composition according to the present invention is characterized in that B) is contained in an amount of 0.5% to 15.0% by weight, preferably 1.0% to 10.0% by weight, more preferably 3.0% to 6.0% by weight, and the weight percentage is based on the total composition.

[0023] The composition according to the invention is preferably a cosmetic formulation.

[0024] Cosmetic formulations containing self-tanning agents are frequently used by people who want to avoid direct exposure of the skin to the sun's UV light but still want to benefit from the advantages of tanned skin.

[0025] Thus, a preferred cosmetic formulation according to the invention comprises at least one UV light-protective filter substance.

[0026] The UV light-protective filters used may be, for example, organic substances which absorb ultraviolet light and can then re-emit the absorbed energy in the form of long-wave radiation, for example heat.

[0027] UVB filters can be oil-soluble or water-soluble. Examples of oil-soluble UVB light-protective filters are 3-benzylidenecamphor and its derivatives, such as 3-(4-methylbenzylidene)camphor, 4-aminobenzoic acid derivatives, such as 2-ethylhexyl 4-(dimethylamino)benzoate and amyl 4-(dimethylamino)benzoate, esters of cinnamic acid, such as 2-ethylhexyl 4-methoxycinnamate, isopentyl 4-methoxycinnamate, 2-ethylhexyl 2-cyano-3-phenylcinnamate (octocrylene), esters of salicylic acid, such as 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate, derivatives of benzophenone, such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, esters of benzalmalonate, such as di-2-ethylhexyl 4-methoxybenzalmalonate, Triazine derivatives such as 2,4,6-trianiolino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazine, octyl triazone, and those described in European Patent No. 1180359 and German Patent Application Publication No. 2004 / 027475 Propane-1,3-diones such as 1-(4-tert-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione are mentioned.

[0028] Suitable water-soluble UVB light protection filters include 2-phenylbenzimidazole-5-sulfonic acid and its alkali metal, alkaline earth metal, ammonium, alkylammonium, alkanolammonium, and guanammonium salts, sulfonic acid derivatives of benzophenone such as 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts, sulfonic acid derivatives of 3-benzylidenecamphor such as 4-(2-oxo-3-bornylidene methyl)benzenesulfonic acid and 2-methyl-5-(2-oxo-3-bornylidene)sulfonic acid and their salts are mentioned.

[0029] Suitable typical UVA light protection filters include, in particular, derivatives of benzoylmethane such as 1-(4'-tert-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione or 1-phenyl-3-(4'-isopropylphenyl)propane-1,3-dione. Of course, it is also possible to use a mixture of a UV-A filter and a UV-B filter.

[0030] In addition to the soluble substances listed, insoluble pigments, i.e., finely divided metal oxides or salts such as titanium dioxide, zinc oxide, iron oxide, aluminum oxide, cerium oxide, zirconium oxide, silicate (talc), barium sulfate and zinc stearate are also suitable for this purpose. The particles here should have an average diameter of less than 100 nm, for example 5 - 50 nm, in particular 15 - 30 nm. The particles may be spherical, but it is also possible to use particles which are elliptical or deviate from the spherical shape in some other way. A relatively new class of light protection filters are micronized organic pigments, for example those of 2,2'-methylenebis{6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol} which can be obtained as a 50% aqueous dispersion and have a particle size of less than 200 nm.

[0031] Further suitable UV light protection filters can be found in the review by P. Finkel in SOFW-Journal 122,543 (1996).

[0032] In connection with the formulations of the present invention, said formulations preferably contain lipophilic hydrophobic UV light protection filter substances, in particular triazine derivatives.

[0033] Here, for use as a UV-B filter, the UV light-protecting filter substances, 2-ethylhexyl 2-cyano-3-phenylcinnamate, 2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine, dioctyl butylamidotriazone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, di-2-ethylhexyl 4-methoxybenzomalonate, 2,4,6-tris-[anilino-(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazine, 2,4-bis[5,1(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)imino]-6-(2-ethylhexyl)imino-1,3,5-triazine, 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine and 2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(octyloxy)phenol are particularly preferred.

[0034] The UV-A filter used is preferably 1-(4'-tert-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione, 1-phenyl-3-(4'-isopropylphenyl)propane-1,3-dione.

[0035] Particularly preferred UV-A filters are 4-(tert-butyl)-4'-methoxydibenzoylmethane (CAS number 70356-09-1) sold under the brand name Parsol® 1789 from DSM and under the trade name Eusolex® 9020 from Merck, and hydroxybenzophenone according to the unique patent application publication number 102004027475, particularly preferably hexyl 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoate (similarly: aminobenzophenone) available under the name Uvinul A Plus from BASF.

[0036] Even more preferred UV filter substances are so-called broad-band filters, i.e., filter substances that absorb both UV-A and UV-B radiation. Among this group, 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol), available under the trade name Tinosorb® M from Ciba Chemikalien GmbH, and 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol (CAS number: 155633-54-8) having the INCI name droxmetrizole trisiloxane are preferably used.

[0037] In addition to the two groups of the above-mentioned primary UV light protection filters, it is also possible to use secondary photo stabilizers of the antioxidant type that stop the chain of photochemical reactions initiated when UV radiation penetrates the skin.

[0038] The cosmetic formulation of the present invention preferably contains a UV light protection filter in an amount of 0.01% to 15% by weight, preferably 0.05% to 10% by weight, more preferably 0.1% to 5% by weight, based on the total formulation.

[0039] Preferably, the cosmetic formulation of the present invention contains a combination of two or more different UV light protection filters.

[0040] When both UVA and UVB light protection filters are used in the formulation of the present invention, the weight ratio of these filters is preferably 1:2 to 1:4.

[0041] The formulation of the present invention is in the following groups, Skin softeners, Emulsifiers, Thickeners / viscosity modifiers / stabilizers, Antioxidants, Hydrotropes (or polyols), Solids and fillers, Film-forming agent Pearlescent additive, Deodorizing and antiperspirant active substance, Insect repellent, Preservative, Conditioning agent, Fragrance, Dye, Odor absorber, Cosmetic active substance, Care additive, Superfatting agent, Solvent It can further contain at least one additional component selected from the following.

[0042] Substances that can be used as exemplary representatives of each group are known to those skilled in the art and can be found, for example, in German Patent Application Publication No. 102008001788.4. This patent application is incorporated herein by reference and thus forms part of the present disclosure.

[0043] Regarding further optional components and the amounts of these components used, reference is particularly made to relevant handbooks known to those skilled in the art, such as K. Schrader, “Grundlagen und Rezepturen der Kosmetika” [Fundamentals and formulations of cosmetics], 2nd edition, pages 329 to 341, Huthig Buch Verlag Heidelberg.

[0044] The amount of each additive is guided by the intended use.

[0045] Typical frame formulations for specific applications are known in the prior art and are included, for example, in the brochures of manufacturers of specific substrates and active ingredients. These existing formulations can generally be adopted as they are. However, if necessary for adjustment and optimization, the desired modifications can be made in a simple manner by simple tests.

[0046] The present invention further provides a sphingolipid of general formula Ib, [Chemical formula] wherein, R 1 is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH2-HCOH, n is 6, or, in the formula, R 1 is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH=CH or CH2-HCOH, preferably CH2-HCOH, n is 5.

[0047] This sphingolipid of general formula Ib has been found to most boost the self-tanning effect.

[0048] The present invention further provides a composition containing a sphingolipid of general formula Ib, preferably a cosmetic formulation. These cosmetic formulations according to the present invention contain a sphingolipid of general formula Ib in the preferred manner described above for component A) of the composition according to the present invention.

[0049] The present invention further provides a sphingolipid of general formula Ib for use as a pharmaceutical, [Chemical formula] wherein, R 1 is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH2-HCOH, n is 6, or, in the formula, R 1is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH=CH or CH2-HCOH, preferably CH2-HCOH, n is 5.

[0050] The present invention further provides a sphingolipid of general formula Ib for use in the treatment of acne, atopic dermatitis, psoriasis, herpes, warts, rosacea, skin cancer, pemphigus, alopecia, epidermolysis bullosa, scleroderma, ichthyosis, vitiligo and / or Raynaud's phenomenon, [Chemical formula] wherein, R 1 is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH2-HCOH, n is 6, or or, in the formula, R 1 is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH=CH or CH2-HCOH, preferably CH2-HCOH, n is 5.

[0051] The present invention provides at least one sphingolipid of general formula I for enhancing the self-tanning effect of a self-tanning agent, [Chemical formula] wherein, R 1 is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, X is CH=CH, CH2-CH2 or CH2-HCOH, preferably CH2-HCOH, n is selected from integers of 3 to 8, preferably 6 to 7, most preferably 6, and / or at least one sphingoid base selected from the group consisting of N-acetylphytosphingosine, phytosphingosine, sphingosine and sphinganine is further provided.

[0052] The present invention further provides the use of at least one composition according to the present invention for sunburn of human skin.

[0053] Preferably, the same preferred components A) and B) are used in the same preferred embodiments in the use of the composition according to the present invention described above.

[0054] The use of the present invention is a non-pharmaceutical use in cosmetics.

[0055] The examples presented below illustrate the present invention by way of example, and the present invention is not intended to be limited to the embodiments embodied in the examples, the scope of application of which is clear from the entire specification and claims.

[0056] Examples Example 1: Boost of self-tanning DHA Experiments according to the present invention are marked with *.

[0057] Eight panels of 10 persons each are tested as follows.

[0058] A formulation containing DHA is applied to the left anterior forearm, and a formulation containing DHA and a potential booster compound is applied to the right anterior forearm. [Table 1]

[0059] The treatment is repeated daily for a period of one week (2.5 ml on each side).

[0060] Sunburn is evaluated on a scale of 0 (no effect) to 5 (very strong sunburn).

[0061] The average values are shown in the following table.

Table 2

[0062] As can be seen from the above, only ceramides and sphingoid bases having an odd number of carbon atoms can boost the self-tanning effect.

[0063] Example 2: Boost of Self-Tanning Erythrulose The data is generated in the same manner as in Example 1, but erythrulose is used instead of DHA.

Table 3

[0064] The average values are shown in the following table.

Table 4

[0065] As can be seen from the above, only ceramides having an odd number of carbon atoms can boost the self-tanning effect.

[0066] Example 3: Example Formulation

Table 5

[0067] Preparation: Heat Phase A and Phase B to 85°C. Add Phase A to Phase B with stirring. Homogenize. Cool to 40°C with stirring. Add Phase C and Phase D. Cool to 30°C with stirring.

[0068]

Table 6

[0069] Preparation: Heat Phase A and Phase B to 85°C. Add Phase A to Phase B with stirring. Homogenize. Cool to 40°C with stirring. Add Phase C and Phase D. Cool to 30°C with stirring.

[0070]

Table 7

[0071] Preparation: Heat Phase A and Phase B to 85°C. Add Phase A to Phase B with stirring. Homogenize. Cool to 40°C with stirring. Add Phase C and Phase D. Cool to 30°C with stirring.

[0072]

Table 8

[0073] Preparation: Heat Phase A and Phase B to 85°C. Add Phase A to Phase B with stirring. Homogenize. Cool to about 40°C with gentle stirring and add Phase C. Homogenize briefly. Add Phase D and Phase E little by little.

[0074]

Table 9

[0075] Preparation: Heat Phase A and Phase B separately to about 85°C. Add Phase A to Phase B. Homogenize. Cool to about 50°C with gentle stirring and then add Phase C. Homogenize. Cool to about 35°C with gentle stirring and then add Phase D, Phase E and Phase F. Adjust the pH to 6.5 - 7.0 with Phase E.

[0076]

Table 10

[0077] Preparation: Heat phase B to approximately 85°C until ceramide NP C15 and ceramide NP C17 are each clearly solubilized. Slowly add phase B to phase A (20 - 22°C) with stirring. Add phase C, phase D, and phase E. Adjust the pH to pH 5 - 5.5 with phase F.

[0078]

Table 11

[0079] Preparation Mix the components in the given order and heat to 85°C. Stir slowly until a clear solution is formed. Cool.

Table 12

[0080] Preparation Heat phase B to 85°C with stirring. Cool to room temperature. Add phase A to phase B with gentle stirring. Prepare phase C by dispersing xanthan gum in water. Slowly add phase C little by little with stirring. Adjust the pH to 5.0 - 5.5 with phase D.

[0081]

Table 13

[0082] Preparation: Heat sodium lauryl sulfate, dermofeel sensolv MB, dermofeel G10 LW 70 MB, ceramide NP C15, and ceramide NP C17 each to 85°C until the solution becomes clear. Add the other components little by little in the given order. Cool to 30°C with stirring.

[0083]

Table 14

[0084] Preparation Heat RHEANCE One, Ceramide NP C15, and Ceramide NP C17 to 85°C. Cool to 40°C. Dissolve the fragrance. Slowly add water with stirring, and then add the remaining ingredients in the given order.

[0085]

Table 15

[0086] Preparation Heat Phase A to 80°C and disperse Phase B in Phase A. Heat Phase C separately to 85°C. Add Phase C to Phase A / B. Cool to 35°C and add Phase D in the given order with slow stirring. Add Phase E to adjust the pH value.

[0087]

Table 16

[0088] Preparation Heat sodium lauryl sulfate, Verstatil PC, ANTIL SOFT SC MB, Ceramide NP C15, and Ceramide NP C17 to 85°C. Add the other ingredients little by little with stirring.

[0089]

Table 17

[0090] Preparation Heat Phase A and Phase B to 85°C. Add Phase A to Phase B with stirring. Homogenize. Cool to 50°C with gentle stirring. Add Phase C at about 50°C. Homogenize again for a short time. Cool to about 35°C with gentle stirring. Prepare Phase D. Add Phase D with stirring. Adjust the pH to 4.0 - 5.0 with Phase E.

[0091]

Table 18

[0092] Preparation Heat phase A and phase B to 85°C. Add phase B to phase A without stirring. Homogenize. Cool to 30°C with stirring.

[0093]

Table 19

[0094] Preparation Heat phase A to about 85°C. Slowly add phase B (80°C or room temperature) with stirring. Homogenize briefly. Cool to below 30°C with gentle stirring and homogenize again.

[0095] 20.1 Cream for the treatment of sensitive skin A 1.50 wt% TEGO® Care 450 MB (polyglyceryl-3 methylglucose distearate) 0.50 wt% ABIL® Care XL 80 MB (bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 dimethicone; methoxy PEG / PPG-25 / 4 dimethicone; caprylic / capric triglyceride) 1.50 wt% stearyl alcohol 2.50 wt% TEGIN® M Pellets MB (glyceryl stearate) 6.50 wt% TEGOSOFT® M (isopropyl myristate) 4.80 wt% TEGOSOFT® APM (PPG-3 myristyl ether) 0.50 wt% TEGOSOFT® MM MB (myristyl myristate) 0.10 wt% ceramide NP 15 0.10 wt% SPHINGOKINE NP (caprylic oil phytosphingosine) B 1.00 wt% TEGO® Natural Betaine (betaine) 3.00 wt% glycerin ad 100% by weight water 0.20% by weight Carbomer 0.10% by weight Xanthan gum 0.80% by weight TEGOSOFT® M (Isopropyl myristate) D q.s. Sodium hydroxide (10% in water) 1.00% by weight Verstatil® PC (Phenoxyethanol; Caprylyl glycol) q.s. Perfume

[0096] 20.2 Facial mask for reactive skin A 0.50% by weight ABIL® Care XL 80 MB (Bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 dimethicone; Methoxy PEG / PPG-25 / 4 dimethicone; Caprylic / capric triglyceride) 1.50% by weight ABIL® 350 (Dimethicone) 4.00% by weight TEGOSOFT® OS (Ethylhexyl stearate) 4.00% by weight TEGOSOFT® CT MB (Caprylic / capric triglyceride) 0.10% by weight Ceramide NP 15 B 0.60% by weight TEGO® Carbomer 341 ER (Acrylate / C10-30 alkyl acrylate crosspolymer) 0.10% by weight HyaCare® (Sodium hyaluronate) 0.10% by weight HyaCare® 50 (Hydrolyzed hyaluronic acid) 5.00% by weight Glycerin ad 100% by weight water C 1.00% by weight Verstatil® PC (Phenoxyethanol; Caprylyl glycol) D q.s. Sodium hydroxide (10% in water)

[0097] 20.3 Microbiome balancing serum A 0.30 wt% TEGO® Carbomer 341 ER (acrylate / C10 - 30 alkyl acrylate crosspolymer) ad 100 wt% water B q.s. sodium hydroxide (10% in water) C 1.00 wt% TEGO® SML 20 MB (polysorbate 20) 0.10 wt% ceramide NP 15 D 3.00 wt% InuMax Advanced Retinol (aqua; caprylic / capric triglyceride; glycerin; polysorbate 20; retinol; inulin laurylcarbamate; behentrimonium chloride; sucrose laurate; BHT; BHA; phenoxyethanol; benzoic acid; dehydroacetic acid; ethylhexylglycerin; disodium EDTA) E 2.00 wt% Verstatil® PC (phenoxyethanol; caprylyl glycol)

[0098] 20.4 Skin Tone Balancing Cream A ad 100 wt% water, deionized 2.00 wt% glycerin 99.5%, Ph.Eur. (glycerin) 0.10 wt% dermofeel® PA - 3 (sodium phytate; aqua; alcohol) A1 0.30 wt% xanthan gum FEDCS - PC (xanthan gum) B 1.00 wt% TEGO® Feel C 10 (cellulose) 6.00 wt% symbio® muls GC MB (glyceryl stearate citrate; cetearyl alcohol; glyceryl caprylate) 6.00 wt% TEGOSOFT® DC MB (decyl cocoate) 2.00% by weight dermosoft® decalact sebum MB (Polyglyceryl-10 laurate; Sodium caproyl / lauroyl lactylate; Glycerin, Serenoa Serrulata fruit extract; Juniperus Communis fruit extract) 0.10% by weight dermofeel® Toco 70 non GMO (Tocopherol; Helianthus Annuus (Sunflower) seed oil) 0.05% by weight Ceramide NP 15 0.05% by weight SPHINOX Defenda (Hydroxybutyroyl phytosphingosine) 0.1% TEGO Sterol 7-DHC (7-Dehydrocholesterol) C 3.00% by weight dermosoft® 1388 eco (Glycerin; Aqua; Sodium levulinate; Sodium anisate) 0.15% by weight Fragrance

[0099] 20.5 Moisturizing Lip Mask A 0.02% by weight HyaCare® (Sodium hyaluronate) 9.96% by weight Glycerin ad 100% by weight Water 0.02% by weight Rouge Covarine W 3799 (CI12490; Aqua; Glycerin) 0.02% by weight Rouge Covarine W 3799 (CI12490; Aqua; Glycerin) B 8.00% by weight TEGOSOFT® DC MB (Decyl cocoate) 2.00% by weight TEGOSOFT® OER MB (Oleyl erucate) 3.00% by weight TEGOSOFT® MM MB (Myristyl myristate) 7.00% by weight TEGOSOFT® P (Isopropyl palmitate) 3.00% by weight of ISOLAN® GPS (polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate) 6.00% by weight of TEGOSOFT® SH MB (stearyl heptanoate) 1.00% by weight of Cera Alba 10.00% by weight of candelilla wax (Candelilla Cera) 3.00% by weight of Copernicia Cerifera (carnauba) wax 3.50% by weight of Butyrospermum Parkii (shea) butter 33.49% by weight of SAT-Y-338073 (yellow iron oxide) 33.49% by weight of Schercemol PTID Ester (triisostearoyl polyglyceryl-3 dimer dilinoleate) 0.10% by weight of ceramide NP 15 2.00% by weight of HyaCare® Filler CL MB (aqua; ethylhexyl stearate; sodium hyaluronate crosspolymer; polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate; sodium isostearate)

[0100] Sleeping mask for the treatment of photoaged skin A 0.50% by weight of ABIL® Care XL 80 MB (bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 dimethicone; methoxy PEG / PPG-25 / 4 dimethicone; caprylic / capric triglyceride) 1.50% by weight of ABIL® Wax 9840 (cetyl dimethicone) 4.00% by weight of TEGOSOFT® OS (ethylhexyl stearate) 4.00% by weight of TEGOSOFT® CT MB (caprylic / capric triglyceride) 0.10% by weight of ceramide NP 15 3.00 wt% TEGO® CBD Revitalize (Amaranthus Caudatus seed extract (and) cholesterol (and) cannabidiol (and) glyceryl caprylate) B ad 100 wt% water 5.00 wt% glycerin 0.05 wt% KELCOGEL CG-HA (gellan gum) 0.40 wt% carbomer (carbomer homopolymer C) C 2.00 wt% TEGO® Natural Betaine (betaine) 0.50 wt% TEGO® Turmerone (Curcuma longa (turmeric) root extract) D q.s. sodium hydroxide (10% in water) E 0.80 wt% Verstatil® PC (phenoxyethanol; caprylyl glycol)

[0101] 20.7 Anti-cellulite body mask A ad 100 wt% water, deionized 4.50 wt% glycerin 99.5%, Ph.Eur. (glycerin) 0.10 wt% dermofeel® PA-3 (sodium phytate; aqua; alcohol) 0.80 wt% xanthan gum FEDCS-PC (xanthan gum) B 5.00 wt% phytosqualane, purified, olive-based (squalane) B1 8.00 wt% symbio® muls GC MB (glyceryl stearate citrate; cetearyl alcohol; glyceryl caprylate) 2.00 wt% TEGIN® M Pellets MB (glyceryl stearate) 2.00 wt% KahlWax 8104 (Cera Alba) 2.00 wt% KahlWax 6614 (Camellia Sinensis leaf extract) 2.00 wt% Shea Butter, refined, organic (Butyrospermum Parkii butter) 5.00 wt% Almond oil, refined (Prunus Amygdalus Dulcis oil) 3.00 wt% Avocado oil, refined (Persea Gratissima oil) 2.00 wt% Apricot kernel oil, refined (Prunus Armeniaca kernel oil) 0.20 wt% dermofeel® Toco 70 non GMO (Tocopherol; Helianthus Annuus (Sunflower) seed oil) 0.10 wt% Ceramide NP 15 1.00 wt% dermofeel® TocoSkin (Tocopherol; Helianthus Annuus (Sunflower) seed oil) C 0.50 wt% TEGO® Turmerone (Curcuma longa (Turmeric) root extract) 0.50 wt% Pumpkin seed (Kuerbiskern) organic extract P-00025487 (Helianthus Annuus hybrid oil; Cucurbita Pepo seed extract; Rosmarinus Officinalis leaf extract) 3.5 wt% dermosoft® 1388 eco NaL (Glycerin, Aqua, Sodium Levulinate, p-Anisic Acid, Sodium Hydroxide) D 1.00 wt% SKINMIMICS® MB (Ceramide NP; Ceramide NG; Ceramide EOS; Ceramide EOP; Ceramide AP; Caprylic Oil Phytosphingosine; Caprylic Oil Sphingosine; Behenic Acid; Cholesterol; Ceteareth-25; Glycerin; Cetyl Alcohol; Phenoxyethanol; Ethylhexylglycerin; Tocopherol; Ascorbyl Palmitate; Lecithin; Glyceryl Stearate; Glyceryl Oleate; Citric Acid; Aqua)

[0102] 20.8 Skin Soothing Aftershave Serum A ad 100 wt% Water, Deionized 0.10 wt% dermofeel® PA-3 (Sodium Phytate; Aqua; Alcohol) 3.00 wt% dermosoft® OM (Methylpropanediol; Caprylyl Glycol) 5.00 wt% Glycerin 99.5%, Ph.Eur. (Glycerin) B 2.50 wt% symbio® prot V MB (Hydrolyzed Vegetable Protein; Sodium Citrate; Magnesium Stearate; Xanthan Gum) 0.50 wt% TEGIN® M Pellets MB (Glyceryl Stearate) 4.00 wt% TEGOSOFT® DC MB (Decyl Cocoate) 0.50 wt% Phytosqualane (Squalane) 1.00 wt% TEGO® Feel C 10 (Cellulose) 0.20 wt% dermofeel® Toco 70 non GMO (Tocopherol; Helianthus Annuus (Sunflower) Seed Oil) 2.00% by weight of dermosoft® decalact sebum MB (polyglyceryl-10 laurate; sodium caproyl / lauroyl lactylate; glycerin, Serenoa Serrulata fruit extract; Juniperus Communis fruit extract) 0.10% by weight of ceramide NP 15 0.10% by weight of phytosphingosine (phytosphingosine) C 3.00% by weight of denatured ethanol (denatured alcohol)

[0103] 20.9 Hair and Scalp Serum A 2.00% by weight of TEGO® Care LTP MB (sorbitan laurate; polyglyceryl-4 laurate; dilauryl citrate) 2.67% by weight of TEGOSOFT® CT MB (caprylic / capric triglyceride) 1.33% by weight of dermofeel® sensolv MB (isoamyl laurate) 1.00% by weight of Hairflux® (ceramide NG; Olea Europaea (olive) fruit oil; Ricinus Communis (castor) seed oil) 0.10% by weight of ceramide NP 15 0.05% of SPHINGONY® (sphinganine) B ad 100% by weight of water 3.00% by weight of glycerin C 2.00% by weight of dermofeel® sensolv MB (isoamyl laurate) 0.10% by weight of carbomer (carbomer homopolymer A) 0.10% by weight of acrylate / C10 - C30 alkyl acrylate crosspolymer (carbomer copolymer C) D 2.00% by weight of water 0.005 wt% TEGO® Pep 3-Boost (Copper Tripeptide 34) E 1.00 wt% Verstatil® PC (Phenoxyethanol; Caprylyl Glycol) q.s. Sodium Hydroxide (10% in water)

[0104] 20.10 Anti-Aging Low-Viscosity Facial Serum A 3.00 wt% TEGO® Care PBS 6 MB (Polyglyceryl-6 Stearate (and) Polyglyceryl-6 Behenate) 0.50 wt% TEGIN® M Pellets MB (Glyceryl Stearate) 4.00 wt% TEGOSOFT® DEC (Diethylhexyl Carbonate) 5.00 wt% TEGOSOFT® XC MB (Phenoxyethyl Caprylate) 3.00 wt% dermofeel® sensolv MB (Isoamyl Laurate) 3.00 wt% TEGO® SP 13-1 MB (Poly C10-30 Alkyl Acrylate) 0.10 wt% Ceramide NP 15 0.05 wt% Phytosphingosine SLC (Salicyloyl Phytosphingosine) B ad 100 wt% Water 3.00 wt% Glycerin 0.20 wt% Carbomer (Carbomer Homopolymer A) 0.10 wt% HyaCare® 50 (Hydrolyzed Hyaluronic Acid) C q.s. Sodium Hydroxide (10% in water) D 0.50 wt% BeautiFerm Healerine (Water (Aqua); Ganoderma Lucidum Extract; Glycerin; Propanediol; Xanthan Gum; 1,2-Hexanediol; Caprylyl Glycol) E 1.00 wt% Verstatil® PC (phenoxyethanol; caprylyl glycol) Z q.s. fragrance

[0105] 20.11 Anti-acne serum A 2.00 wt% TEGOSOFT® AC MB (isoamyl cocoate) 2.00 wt% TEGOSOFT® OER MB (oleyl erucate) 1.00 wt% octyldodecanol 1.00 wt% TEGOSOFT® APM (PPG-3 myristyl ether) 0.50 wt% TEGO® Turmerone (Curcuma longa root extract) 0.05 wt% ceramide NP 15 0.07 wt% SPHINGONY® (sphinganine) B 0.50 wt% TEGO® Carbomer 341 ER (acrylate / C10-30 alkyl acrylate crosspolymer) 5.00 wt% glycerin 3.00 wt% alcohol ad 100 wt% water C q.s. sodium hydroxide (10% in water) Z q.s. preservative

[0106] 20.12 O / W aftershave cream for the treatment of irritated skin A 1.5 wt% AXOL® C 62 Pellets MB (glyceryl stearate citrate) 2.0 wt% TEGIN® M Pellets MB (glyceryl stearate) 3.0 wt% TEGO® Alkanol 1618 MB (cetearyl alcohol) 3.5 wt% TEGOSOFT® TN (C12-15 alkyl benzoate) 2.0 wt% TEGOSOFT® CR MB (Cetyl Ricinoleate) 1.0 wt% Triisostearin 0.5 wt% TEGOSOFT® MM MB (Myristyl Myristate) 4.0 wt% Cyclopentasiloxane 2.0 wt% Macadamia Ternifolia Seed Oil 0.5 wt% Tocopheryl Acetate 0.10 wt% Ceramide NP 15 0.10 wt% Bodyflux® Olive (Ceramide NP) B 4.0 wt% Glycerin 0.5 wt% Panthenol 0.2 wt% Allantoin ad 100 wt% Water C 0.3 wt% Carbomer (Carbomer Homopolymer B) 1.2 wt% TEGOSOFT® TN (C12 - 15 Alkyl Benzoate) D 0.5 wt% Bisabolol E q.s. Sodium Hydroxide (10% in Water) F 7.0 wt% Alcohol G 0.7 wt% Euxyl PE 9010 (Phenoxyethanol, Ethylhexylglycerin) Z q.s. Perfume

[0107] 20.13 Aftersun Gel for Sun Protection A 1.5 wt% TEGOSOFT® liquid (Cetearyl Ethylhexanoate) 0.6 wt% ABIL® B 8832 (Bis - PEG / PPG - 20 / 20 Dimethicone) 0.10 wt% Ceramide NP 15 B 0.3 wt% dermosoft® GMCY MB (Glyceryl Caprylate) 0.5 wt% TEGO® Cosmo C 250 (1-methylhydantoin-2-imide) 0.03 wt% HyaCare® (sodium hyaluronate) 3.00 wt% glycerin 3.00 wt% butylene glycol ad 100 wt% water, desalted 0.2 wt% carbomer (carbomer homopolymer C) 0.7 wt% Aristoflex® HMB (ammonium acryloyldimethyltaurate, beheneth-25 methacrylate crosspolymer) C 1.00 wt% dermosoft® hexiol (1,2 - hexanediol) q.s. sodium hydroxide 0.25 wt% Red 28 (0.02% in water) D ROVISOME® Sensitive NG (water / aqua; glycerin; lecithin; dipotassium glycyrrhizinate; Calendula officinalis extract; Lonicera Caprifolium flower extract; Lonicera Japonica flower extract; benzyl alcohol; benzoic acid; dehydroacetic acid)

[0108] 20.14 Sun Cream SPF15 A 3.00 wt% TEGO® Care PBS 6 MB (polyglyceryl - 6 stearate (and) polyglyceryl - 6 behenate) 8.00 wt% TEGOSOFT® XC MB (phenoxyethyl caprylate) 5.00 wt% TEGOSOFT® DEC (diethylhexyl carbonate) 3.00 wt% TEGIN® M Pellets MB (glyceryl stearate) 2.00 wt% TEGO® Alkanol 1618 MB (cetearyl alcohol) 1.00 wt% TEGOSOFT® MM MB (Myristyl Myristate) 0.50 wt% ABIL® 350 (Dimethicone) 0.50 wt% TEGO® Feel C 10 (Cellulose) 2.50 wt% Diethylamino Hydroxybenzoyl Hexyl Benzoate 6.00 wt% Homosalate 0.50 wt% Tocopheryl Acetate 0.10 wt% Ceramide NP 15 B 11.58 wt% Water 0.42 wt% Sodium Hydroxide 3.00 wt% Eusolex 232 (Phenylbenzimidazole Sulfonic Acid) C ad 100 wt% Water 3.00 wt% Glycerin 1.00 wt% TEGO® Pep 4-17 MB (Tetrapeptide-21; Glycerin; Butylene Glycol; Aqua) 1.00 wt% TEGO® Pep 4-Even MB (Tetrapeptide-30; Glycerin; Water) 0.50 wt% TEGO® Cosmo C 100 (Creatine) D 0.70 wt% Keltrol CG-SFT (Xanthan Gum) E 1.10 wt% Verstatil® PC (Phenoxyethanol; Caprylyl Glycol) 0.50 wt% Fragrance

[0109] 20.15 UV Protection Hand Cream SPF20 A 1.50 wt% TEGO® Care PBS 6 MB (Polyglyceryl-6 Stearate (and) Polyglyceryl-6 Behenate) 2.50 wt% VARISOFT® TA 100 (Distearyldimonium Chloride) 2.00 wt% Stearyl Alcohol 2.00 wt% TEGIN® M Pellets MB (Glyceryl Stearate) 1.00 wt% TEGOSOFT® SH MB (Stearyl Heptanoate) 5.00 wt% TEGOSOFT® TN (C12 - 15 Alkyl Benzoate) 3.00 wt% Diethylamino Hydroxybenzoyl Hexyl Benzoate 3.00 wt% Ethylhexyl Salicylate 5.00 wt% Ethylhexyl Methoxycinnamate 0.50 wt% Tocopheryl Acetate 0.10 wt% Ceramide NP 15 0.05% TEGO® Sterol KCS (Cholesteryl Potassium Sulfate) B ad 100 wt% Water 3.00 wt% Glycerin C 1.50 wt% Nylon - 12 D 2.00 wt% TEGO® Natural Betaine (Betaine) 2.00 wt% LACTIL® (Sodium Lactate; Sodium PCA; Glycine; Fructose; Urea; Niacinamide; Inositol; Sodium Benzoate; Lactic Acid) 2.00 wt% Water E q.s. Preservative 0.50 wt% Fragrance "Azura 231517"

[0110] 20.16 Sunscreen Lotion SPF30 with Insect Repellent Activity A 3.50 wt% TEGO® Care PBS 6 MB (Polyglyceryl - 6 Stearate (and) Polyglyceryl - 6 Behenate) 2.00 wt% TEGOSOFT® DC MB (Decyl Cocoate) 1.00 wt% TEGOSOFT® TN (C12 - 15 Alkyl Benzoate) 0.50 wt% REWOPAL® PIB 1000 (Polyisobutene) 0.50 wt% TEGIN® M Pellets MB (Glyceryl Stearate) 0.50 wt% Stearyl Alcohol 15.00 wt% Insect Repellent 3535 (Ethyl Butylacetylaminopropionate) 3.00 wt% Tinosorb S (Bis-Ethylhexyl Oxyphenol Methoxyphenyl Triazine) 3.00 wt% Ethylhexyl Salicylate 6.00 wt% Homosalate 8.00 wt% Octocrylene 2.00 wt% Butyl Methoxydibenzoylmethane 2.00 wt% Ethylhexyl Methoxycinnamate 0.10 wt% Ceramide NP 15 B ad 100 wt% Water 3.00 wt% Glycerin C 0.60 wt% Sepigel 305 (Polyacrylamide (and) C13 - 14 Isoparaffin (and) Laureth - 7) D 0.70 wt% EUXYL PE 9010 (Phenoxyethanol; Ethylhexylglycerin) Z q.s. Perfume

[0111] 20.17 O / W Foundation for Skin Tone Uniformity A 4.00 wt% TEGO® Care PBS 6 MB (Polyglyceryl - 6 Stearate (and) Polyglyceryl - 6 Behenate) 1.50 wt% TEGO® Alkanol 1618 MB (Cetearyl Alcohol) 1.00 wt% TEGIN® M Pellets MB (Glyceryl Stearate) 1.00 wt% TEGOSOFT® MM MB (Myristyl Myristate) 3.00 wt% TEGOSOFT® TN (C12 - 15 Alkyl Benzoate) 2.00 wt% TEGOSOFT® DEC (Diethylhexyl Carbonate) 2.00 wt% 9045 Silicone Elastomer Blend (Cyclopentasiloxane (and) Dimethicone Crosspolymer) 8.00 wt% Ethylhexyl Methoxycinnamate 5.00 wt% Ethylhexyl Salicylate 3.00 wt% Diethylamino Hydroxybenzoyl Hexyl Benzoate 3.00 wt% Bis-Ethylhexyl Oxyphenol Methoxyphenyl Triazine (Bis-Ethylhexyl Oxyphenol Methoxyphenyl Triazine) 0.10 wt% Ceramide NP 15 B ad 100 wt% Water, Deionized 1.00 wt% Glycerin 0.15 wt% Xanthan Gum C 8.00 wt% Titanium Dioxide; CI 77891 1.70 wt% Covarine Yellow WN 1792 GZ (CI 77492, Aqua, Glycerin, Xanthan Gum, Sodium Citrate) 0.40 wt% Covarine Red WN 3798 GZ (CI 77491, Aqua, Glycerin, Xanthan Gum, Sodium Citrate) 0.10 wt% Covarine Black WN 9798 GZ (CI 77499, Water, Glycerin, Xanthan Gum, Sodium Citrate) 2.00 wt% Glycerin 3.00 wt% Propylene Glycol D 2.00 wt% Nylon-12 E-2.00 wt% ROVISOME® Q10 NG (Aqua; Glycerin; Lecithin; Ubiquinone; Tocopherol; Benzyl Alcohol; Benzoic Acid; Dehydroacetic Acid) F 0.70 wt% Euxyl PE 9010 (Phenoxyethanol, Ethylhexylglycerin)

[0112] 20.18 Facial Care Mousse A 2.50 wt% ABIL® Care XL 80 MB (Bis-PEG / PPG-20 / 5 PEG / PPG-20 / 5 Dimethicone; Methoxy PEG / PPG-25 / 4 Dimethicone; Caprylic / Capric Triglyceride) 5.00 wt% Dimethicone (5 mPas) 4.00 wt% TEGOSOFT® DEC (Diethylhexyl Carbonate) 3.00 wt% TEGOSOFT® CT MB (Caprylic / Capric Triglyceride) 1.00 wt% TEGOSOFT® CR MB (Cetyl Ricinoleate) 0.10 wt% Ceramide NP 15 0.10 wt% SPHINOX® Lift (Ceramide NP) B 4.00 wt% TEGO® Pep UP (Tetrapeptide-4; Glycerin) 0.50 wt% TEGO® Cosmo C 100 (Creatine) 0.50 wt% Panthenol 0.20 wt% Allantoin ad 100 wt% Water C 1.60 wt% TEGOSOFT® OS (Ethylhexyl Stearate) 0.15 wt% Carbomer (Carbomer Homopolymer A) 0.15 wt% Carbomer (Carbomer Homopolymer C) 0.10 wt% Keltrol CG-SFT (Xanthan Gum) D q.s. Sodium Hydroxide (10% in Water) E 1.00 wt% TEGO® Betain 810 MB (Capryl / Capramidopropyl Betaine) 1.00 wt% REWOTERIC® AM C MB (Sodium Cocamphoacetate) 0.70 wt% Euxyl PE 9010 (Phenoxyethanol, Ethylhexylglycerin) Z q.s. fragrance

[0113] 20.19 Facial mask A 1.00 wt% TEGOSOFT® PC 41 MB (polyglyceryl-4 caprate) 1.30 wt% TEGO® Betain 810 MB (capryl / capramidopropyl betaine) 1.00 wt% TEGO® Solve 61 MB (polyglyceryl-6 caprylate; polyglyceryl-3 cocoate; polyglyceryl-4 caprate; polyglyceryl-6 ricinoleate) 1.00 wt% glycerin 1.40 wt% hexylene glycol 0.10 wt% ceramide NP 15 B 0.50 wt% TEGO® Carbomer 140 (carbomer) 2.00 wt% TEGO® Natural Betaine (betaine) ad 100 wt% water 0.10 wt% xanthan gum C 2.50 wt% TEGO® Feel C 10 (cellulose) 0.50 wt% TEGO® Turmerone (Curcuma longa (turmeric) root extract) 3.00 wt% Verstatil® BOB (benzyl alcohol; caprylyl glycol; benzoic acid) q.s. wt% sodium hydroxide (10% in water) D ROVISOME® ACE NG (glycerin; aqua; lecithin; tocopheryl acetate; 3-o-ethyl ascorbic acid; retinyl palmitate; tocopherol; benzyl alcohol; benzoic acid; dehydroacetic acid)

[0114] 20.20 Aftershave cream A 2.00 wt% AXOL® C 62 Pellets MB (Glyceryl Stearate Citrate) 2.00 wt% TEGIN® M Pellets MB (Glyceryl Stearate) 3.00 wt% TEGO® Alkanol 1618 MB (Cetearyl Alcohol) 4.00 wt% TEGOSOFT® DEC (Diethylhexyl Carbonate) 3.50 wt% TEGOSOFT® DC MB (Decyl Cocoate) 2.00 wt% TEGOSOFT® CR MB (Cetyl Ricinoleate) 1.00 wt% TEGOSOFT® OER MB (Oleyl Erucate) 0.50 wt% TEGOSOFT® MM MB (Myristyl Myristate) 2.00 wt% Macadamia Ternifolia Seed Oil 0.50 wt% Tocopheryl Acetate 0.50 wt% Bisabolol 0.50 wt% dermosoft® GMCY MB (Glyceryl Caprylate) 0.10 wt% Ceramide NP 15 B ad 100 wt% Water 4.0 wt% Glycerin 0.50 wt% Panthenol 0.20 wt% Allantoin C 0.40 wt% Keltrol CG-SFT (Xanthan Gum) D 7.00 wt% Alcohol E 0.01 wt% TEGO® Natural Citrus (Citrus reticulata (Tangerine) Peel Extract) 0.02 wt% TEGO® Natural Matricaria (Chamomilla recutita (Matricaria) Flower Extract) E 1.50 wt% Verstatil® SL non GMO (Aqua; Sodium Levulinate; Potassium Sorbate)

[0115] 20.21 Skin Toner A ad 100 wt% Water, deionized 4.00 wt% Glycerin 99.5%, Ph.Eur. (Glycerin) 0.20 wt% TEGO Natural Madecassoside (Madecassoside) 0.50 wt% Ajidew NL-50N (Sodium PCA; Aqua) 0.10 wt% dermofeel® PA-3 (Sodium Phytate; Aqua; Alcohol) B 1.50 wt% symbio® solv clear plus MB (Caprylyl / Capryl Glucoside; Aqua; Sodium Cocoyl Glutamate; Glyceryl Caprylate; Citric Acid; Polyglyceryl-6 Oleate; Sodium Surfactin) 1.00 wt% dermosoft® decalact liquid MB (Sodium Caproyl / Lauroyl Lactylate; Triethyl Citrate) 0.10 wt% Ceramide NP 15 25.00 wt% Denatured Ethanol (Denatured Alcohol) 0.30 wt% Fragrance 2.00 wt% dermofeel® TEC eco (Triethyl Citrate)

[0116] 20.22 Hair and Body Shampoo 2.25 wt% RHEANCE® One (Glycolipid) 0.50 wt% dermofeel® sensolv MB (Isoamyl Laurate) 9.70 wt% Lauryl Glucoside, 50% 20.00 wt% Coco-Glucoside (50%) 5.50 wt% Sodium Coco-Sulfate, 91% 0.10 wt% Ceramide NP 15 ad 100.00 wt% Water 6.80 wt% Glycerin 3.50 wt% dermosoft® 1388 eco (Glycerin; Aqua; Sodium Levulinate; Sodium Anisate) 1.05 wt% TEGO® Remo 95 MB (Sorbitan Caprylate, Glyceryl Oleate) Adjust the pH with citric acid

[0117] 20.23 Micellar Water for Facial Cleansing 2.00 wt% TEGO® Solve 55 MB (Polyglyceryl-3 Caprylate / Caprate / Succinate; Propylene Glycol) 1.30 wt% TEGO® Betain 810 MB (Capryl / Capramidopropyl Betaine) 0.10 wt% Ceramide NP 15 0.05 wt% Perfume ad 100.0 wt% Water 2.00 wt% TEGO® Natural Betaine (Betaine) 2.00 wt% TEGO Cosmo EPL (Polyepsilonlysine Hydrochloride) 1.40 wt% Hexylene Glycol 1.00 wt% Glycerin q.s. Preservative

[0118] 20.24 Leave-in Hair Conditioner for Dry Hair A 5.00 wt% TEGO® Sulfosuccinate DO 75 (Diethylhexyl Sodium Sulfosuccinate) 10.00 wt% dermofeel® sensolv MB (Isoamyl Laurate) 48.00 wt% TEGOSOFT® TN (C12 - 15 Alkyl Benzoate) 30.00 wt% Helianthus Annuus (Sunflower) Seed Oil 0.10 wt% Ceramide NP 15 B 5.00 wt% TEGOSOFT® PC 31 MB (Polyglyceryl-3 Caprylate) 1.00 wt% VARISOFT® EQ 100 (Bis-(Isostearoyl / Oleoyl Isopropyl) Dimonium Methosulfate)

[0119] 20.25 W / O Lotion A 2.5 wt% ISOLAN® GPS (Polyglyceryl-4 Diisostearate / Polyhydroxystearate / Sebacate) 10.0 wt% TEGOSOFT® DEC (Diethylhexyl Carbonate) 9.0 wt% TEGOSOFT® OP (Ethylhexyl Palmitate) 0.5 wt% Zinc Stearate 0.10 wt% Ceramide NP 15 B ad 100.0 wt% Water 3.0 wt% Glycerin 1.5 wt% Magnesium Sulfate Heptahydrate Z q.s. Preservative, Fragrance

[0120] 20.26 Natural Hair Oil for Thin Hair A 92.78 wt% dermofeel® sensolv MB (Isoamyl Laurate) 1.00 wt% TEGOSOFT® DC (Decyl Cocoate) 1.00 wt% Argania Spinosa Kernel Oil 1.00 wt% Brassica Oleracea Italica Seed Oil (Broccoli Seed Oil) 0.5 wt% Daucus Carota Sativa Juice; Sesamum Indicum Seed Oil (Carrot Oil 1.00 wt% Hairflux® (Olea Europaea (olive) fruit oil; Ricinus Communis (castor) seed oil; ceramide NG) 1.00 wt% palm oil 0.02 wt% Hippophae Rhamnoides fruit oil (seabuckthorn pulp oil) 0.50 wt% dermosoft® GMCY MB (glyceryl caprylate) 0.20 wt% dermofeel® Toco 70 non GMO (tocopherol; Helianthus Annuus (sunflower) seed oil) 0.02 wt% ceramide NP 15 0.10 wt% TEGO® Natural Coleus (Coleus Forskohlii extract) B 1.00 wt% fragrance

[0121] 20.27 Waterless Handbar - Solid Hand Cream for Improving Sustainability A 45.80 wt% KahlJelly 7235 MB Natural (Ricinus Communis (castor) seed oil; beeswax; Copernicia Cerifera (carnauba) wax; Helianthus Annuus (sunflower) seed oil; tocopherol; ascorbyl palmitate) 20.00 wt% KahlComplex 6422 Veggisoft (Rhus Verniciflua pericarp wax; Simmondsia Chinensis (Jojoba) seed oil; Cetearyl alcohol; Myristyl alcohol; Caprylic / Capric triglyceride; Copernicia Cerifera (Carnauba) wax; Helianthus Annuus (Sunflower) seed oil) 10.00 wt% Kahlwax 2225 Phyto (Helianthus Annuus (Sunflower) seed wax; Olea Europaea (Olive) oil; Rhus Verniciflua pericarp wax; Shorea Robusta resin) 5.00 wt% Kahlwax 660 / H Hydrolyzed Sunflower (Hydrolyzed sunflower seed wax) 6.00 wt% TEGOSOFT® OER MB (Oleyl erucate) 5.00 wt% TEGOSOFT® DC MB (Decyl cocoate) 2.00 wt% TEGOSOFT® CR MB (Cetyl ricinoleate) 2.70 wt% Olea Europaea (Olive) fruit oil 2.00 wt% dermofeel® viscolid MB (Hydrogenated palm oil; Hydrogenated rapeseed oil) 0.50 wt% dermosoft® GMCY MB (Glyceryl caprylate) 0.20 wt% dermofeel® TocoSkin (Tocopherol; Helianthus Annuus (Sunflower) seed oil) 0.20 wt% dermofeel® Toco 70 non GMO (Tocopherol; Helianthus Annuus (Sunflower) seed oil) 0.10 wt% Ceramide NP 15 0.50 wt% Fragrance

[0122] 20.28 Shaping Body Butter A 43.20 wt% Kahlwax 6237 Rapeseed (Hydrogenated Rapeseed Oil) 8.90 wt% Kahlwax 6607L (Helianthus Annuus Seed Wax); Tocopherol; Ascorbyl Palmitate 3.00 wt% Kahlwax 2811 Rice (Oryza Sativa Rice Bran Wax) 12.50 wt% Prunus Amygdalus Dulcis (Sweet Almond) Oil 11.50 wt% TEGOSOFT® DC MB (Decyl Cocoate) 5.00 wt% TEGOSOFT® OER MB (Oleyl Erucate) 3.00 wt% TEGOSOFT® CR MB (Cetyl Ricinoleate) 2.00 wt% TEGOSOFT® MM MB (Myristyl Myristate) 2.00 wt% dermofeel® viscolid MB (Hydrogenated Palm Oil; Hydrogenated Rapeseed Oil) 1.30 wt% Argania Spinosa (Argan) Kernel Oil 5.00 wt% Persea Gratissima (Avocado) Oil 0.50 wt% dermosoft® GMCY MB (Glyceryl Caprylate) 0.20 wt% dermofeel® TocoSkin (Tocopherol; Helianthus Annuus (Sunflower) Seed Oil) 0.20% by weight dermofeel® Toco 70 non GMO (tocopherol; Helianthus Annuus (sunflower) seed oil) 0.10% by weight ceramide NP 15 0.10% by weight TEGO® Sterol KCS (cholesteryl potassium sulfate) 1.00% by weight Covapate Uniwhite LC 9781 (Ricinus Communis (castor) seed oil; CI 77891; polyhydroxystearic acid) 0.50% by weight fragrance

[0123] 20.29 Conditioning shampoo bar A 45.90% by weight Pureact I-78, 80% (sodium coco isethionate, 80%) 2.50% by weight TEGO® Feel C10 (cellulose) 0.30% by weight Jaguar C-162 (hydroxypropyl guar (and) hydroxypropyl guar hydroxypropyltrimonium chloride) 30.40% by weight Oryza Sativa starch (Resista Natural) 8.00% by weight TEGO® Betain 810 MB (capryl / capramidopropyl betaine) 1.80% by weight RHEANCE® ONE (glycolipid) 4.20% by weight SOPHANCE® LA-A (glycolipid; sodium lactate) 1.00% by weight TEGOSOFT® OER MB (oleyl erucate) 3.00% by weight VARISOFT® EQ 90 (dioleoylethyl hydroxyethylmonium methosulfate) 2.00% by weight TEGO® Remo 95 MB (sorbitan caprylate, glyceryl oleate) 0.50 wt% dermosoft® GMCY (Glyceryl Caprylate) 0.10 wt% Ceramide NP 15 0.30 wt% Fragrance

[0124] 20.30 Cleansing Foam for Oily Skin 6.00 wt% RHEANCE® ONE (Glycolipid) 11.00 wt% TEGO® Betain 810 MB (Caprylyl / Capramidopropyl Betaine) 0.50 wt% TEGO® Remo 95 MB (Sorbitan Caprylate, Glyceryl Oleate) 2.00 wt% dermosoft® decalact sebum MB (Polyglyceryl-10 Laurate; Sodium Caproyl / Lauroyl Lactylate; Glycerin; Serenoa Serrulata Fruit Extract; Juniperus Communis Fruit Extract) 4.00 wt% dermosoft® Pentiol eco (Pentylene Glycol) 0.02 wt% Ceramide NP 15 76.40 wt% Water (Aqua)

[0125] 20.31 AP / Deo Aerosol Spray A 4.00 wt% ISOLAN® 17 MB (Polyglyceryl-4 Diisostearate / Polyhydroxystearate / Sebacate; Caprylic / Capric Triglyceride; Polyglyceryl-3 Oleate; Diisostearoyl Polyglyceryl-3 Dimer Dilinoleate) 0.25 wt% Hydrogenated Castor Oil 0.25 wt% Microcrystalline Wax 20.50 wt% TEGOSOFT® CT (Caprylic / Capric Triglyceride) 10.00 wt% TEGOSOFT® DEC (Diethylhexyl Carbonate) 0.03% by weight of Ceramide NP 15 B 31.97% by weight of Water (Aqua) 2.00% by weight of Glycerin 30.00% by weight of Locron LIC (Aluminum Chlorohydrate (50% Aqueous Solution)) C 1.00% by weight of Fragrance

[0126] 20.32 Odor Reducing Deodorant Stick A 2.50% by weight of dermofeel NC MB (Polyglyceryl-3 Distearate; Glyceryl Stearate Citrate) 20.00% by weight of TEGO® Alkanol 1618 MB (Ceteareth Alcohol) 2.00% by weight of TEGOSOFT® MM (Myristyl Myristate) 10.00% by weight of TEGOSOFT® CR (Cetyl Ricinoleate) 1.00% by weight of TEGODEO® PY 88 G (Zinc Ricinoleate) 10.00% by weight of dermofeel® viscolid MB (Hydrogenated Palm Oil; Hydrogenated Rapeseed Oil) 33.70% by weight of Helianthus Annuus (Sunflower) Seed Oil 10.00% by weight of TEGOSOFT® OER MB (Oleyl Erucate) 0.10% by weight of Ceramide NP 15 4.00% by weight of AEROSIL® 200 (Silica) 6.00% by weight of TEGO® Feel C 10 (Cellulose) 0.30% by weight of TEGO® Cosmo P 813 MB (Polyglyceryl-3 Caprylate) 0.30% by weight of dermosoft® 250 eco (Phenylpropanol) B 0.10% by weight of Bambusa Textilis Stem Extract (Bambusa Tetilis Stem Extract)

[0127] 20.33 Deo wipe A 4.00 wt% TEGODEO® A30 eco (propylene glycol; zinc ricinoleate; aqua; arginine; citric acid) 7.00 wt% TEGO® Solve 90 MB (polyglyceryl-6 caprylate; polyglyceryl 4 caprylate) 0.50 wt% TEGO® Cosmo P 813 MB (polyglyceryl-3 caprylate) 0.25 wt% Texapon K12 G (sodium lauryl sulfate) 0.05 wt% Ceramide NP 15 1.20 wt% Verstatil® TBG (triethyl citrate; glyceryl caprylate; benzoic acid) 0.30 wt% fragrance 2.00 wt% dermofeel® tec eco (triethyl citrate) 0.30 wt% dermosoft® decalact MB (sodium caproyl / lauroyl lactylate; triethyl citrate; Salvia Officinalis (sage) oil) B 82.15 wt% water (aqua) C 2.25 wt% citric acid, 20% aqueous solution

[0128] 20.34 Cationic body butter A 4.50 wt% VARISOFT® TA 100 (distearyldimonium chloride) 4.00 wt% stearyl alcohol 3.00 wt% TEGIN® M Pellets MB (glyceryl stearate) 5.00 wt% TEGOSOFT® CT MB (caprylic / capric triglyceride) 5.00 wt% TEGOSOFT® AC MB (isoamyl cocoate) 5.00 wt% TEGOSOFT® SH (Stearyl heptanoate) 0.50 wt% ABIL® 350 (Dimethicone) 0.10 wt% Ceramide NP 15 B 64.20 wt% Water (Aqua) 5.00 wt% Glycerin C 2.00 wt% ProContour (Aqua; Alcohol; Lecithin; Caffeine; Carnitine; Centella Asiatica leaf extract; Potassium phosphate; Coleus Barbatus root extract; Tocopherol) D 1.00 wt% Verstatil PC (Phenoxyethanol; Caprylyl glycol)

[0129] 20.35 Protective Hand Cream A 2.00 wt% TEGINACID® C Pellets MB (Ceteareth-25 3.50 wt% TEGIN® M Pellets MB (Glyceryl stearate) 2.00 wt% TEGO® Alkanol 1618 MB (Cetearyl alcohol) 7.50 wt% Isopropyl myristate 2.00 wt% TEGOSOFT® DC (Decyl cocoate) 1.00 wt% ABIL® 350 (Dimethicone) 2.00 wt% ABIL® Wax 9840 (Cetyldimethicone) 1.50 wt% Cera Alba 0.08 wt% Ceramide NP B 3.00 wt% Glycerin 0.50 wt% Panthenol 71.90 wt% Water (Aqua) C 2.00 wt% TEGO enlight (Morus Alba fruit extract; Sodium phytate; Aqua; Glycerin; Alcohol) 1.00 wt% Euxyl PE 9010 (phenoxyethanol; ethylhexylglycerin)

[0130] 20.36 Refreshing Foot Cream 6.00 wt% TEGIN® Pellets MB (glyceryl stearate SE) 2.00 wt% TEGO® Alkanol 1618 MB (cetearyl alcohol) 1.00 wt% stearic acid 1.00 wt% ABIL® 350 (dimethicone) 5.00 wt% TEGOSOFT® CT MB (caprylic / capric triglyceride) 5.00 wt% TEGOSOFT® OS (ethylhexyl stearate) 4.00 wt% mineral oil 1.00 wt% TEGO Natural Amaranth (Amaranthus Caudatus seed extract) 0.10 wt% ceramide NP B 7.00 wt% glycerin 64.40 wt% water (aqua) 3.00 wt% sorbitol C 0.50 wt% SK-INFLUX® V MB (ceramide NP; ceramide AP; ceramide EOP; phytosphingosine; cholesterol; sodium lauroyl lactylate; carbomer; xanthan gum) D Verstatil® PC (phenoxyethanol; caprylyl glycol)

[0131] 20.37 Anti-Wrinkle Eye Cream A 3.00 wt% TEGO Care 450 MB (polyglyceryl-3 methylglucose distearate) 1.50 wt% TEGIN M Pellets MB (glyceryl stearate) 1.50 wt% TEGO Alkanol 1618 MB (Cetearyl Alcohol) 2.00 wt% TEGOSOFT CT MB (Caprylic / Capric Triglyceride) 4.00 wt% TEGOSOFT OP MB (Ethylhexyl Palmitate) 9.50 wt% TEGOSOFT DC MB (Decyl Cocoate) 4.00 wt% Prunus Amygdalus Dulcis (Sweet Almond) Oil 0.10 wt% Ceramide NP 15 0.35 wt% dermosoft GMCY MB (Glyceryl Caprylate) B 65.35 wt% Water (Aqua) 3.00 wt% Glycerin C 0.20 wt% Keltrol CG-SFT (Xanthan Gum) D 2.00 wt% TEGO Pep 4-17 MB (Tetrapeptide-21; Glycerin; Butylene Glycol; Water) E 2.00 wt% ROVISOME F.E.C. (Aqua; Alcohol; Lecithin; Escin; Ascophyllum Nodosum Extract; Caffeine; Potassium Phosphate; Tocopherol) F 1.50 wt% Verstatil SL non GMO (Aqua; Sodium Levulinate; Potassium Sorbate)

Claims

1. A) at least one self-tanning agent and, B) at least one sphingolipid of general formula I, 【Chemical 1】 wherein, R １ is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, and X is CH=CH, CH ２ -CH ２ or CH ２ -HCOH, preferably CH ２ -HCOH, and n is selected from integers from 3 to 8, preferably from 6 to 7, most preferably 6, and / or at least one sphingoid base selected from the group consisting of N-acetylphytosphingosine, phytosphingosine, sphingosine and sphinganine A composition comprising.

2. The composition according to claim 1, characterized in that the at least one self-tanning agent is selected from the group consisting of dihydroxyacetone and erythrulose.

3. The sphingolipid of general formula I is wherein, R １ is H, X is CH ２ -HCOH, and n is selected from integers from 6 to 7, most preferably 6, The composition according to claim 1 or 2, characterized in that it is selected from sphingolipids.

4. A) is contained in an amount of 0.02% to 1.50% by weight, preferably 0.03% to 1.00% by weight, more preferably 0.05% to 0.50% by weight, the weight percentage being based on the total composition, The composition according to any one of claims 1 to 3.

5. B) is contained in an amount of 0.5% to 15.0% by weight, preferably 1.0% to 10.0% by weight, more preferably 3.0% to 6.0% by weight, the weight percentage being based on the total composition, The composition according to any one of claims 1 to 4.

6. The composition according to any one of claims 1 to 5, which is a cosmetic formulation.

7. The composition according to claim 6, further comprising at least one UV light protection filter substance.

8. Sphingolipid of general formula Ib [Chemical Formula 2] wherein, R １ is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, and X is CH ２ -HCOH and n is 6, or, wherein, R １ is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, and X is CH=CH or CH ２ -HCOH, preferably CH ２ -HCOH, and n is 5.

9. The sphingolipid according to claim 8, for use as a pharmaceutical.

10. For use in the treatment of acne, atopic dermatitis, psoriasis, herpes, warts, rosacea, skin cancer, pemphigus, alopecia, epidermolysis bullosa, scleroderma, ichthyosis, vitiligo and / or Raynaud's phenomenon, The sphingolipid according to claim 8.

11. A composition comprising the sphingolipid of general formula Ib according to claim 8, preferably a cosmetic formulation.

12. At least one sphingolipid of general formula I for enhancing the self-tanning effect of a self-tanning agent, [Chemical 3] wherein, R １ is H, phosphocholine, serine, ethanolamine or sugar, preferably sugar or H, more preferably H, and X is CH=CH, CH ２ -CH ２ or CH ２ -HCOH, preferably CH ２ -HCOH, and n is selected from integers from 3 to 8, preferably from 6 to 7, most preferably 6, and / or at least one Use of a sphingoid base selected from the group consisting of N-acetylphytosphingosine, phytosphingosine, sphingosine and sphinganine . [

13. ] Cosmetic use of at least one composition according to any one of claims 1 to 7 and 11 for sunburn of human skin.

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