Electrode array for measuring the pH of animal tissue, probe including the electrode array, and assembly including the probe

The electrode array with antimony or conductive polymer-coated stainless steel and ionic liquid-polyurethane reference electrodes addresses invasive and chloride-sensitive issues, enabling non-invasive, real-time pH monitoring of animal tissues.

JP2025521939APending Publication Date: 2025-07-10QUANTUM INNOVATIONS SP ZOO
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Patent Information

Application Number
JP2025500332
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-07-07
Filing Date
2023-07-07
Publication Date
2025-07-10

AI Technical Summary

Technical Problem

Existing pH measurement technologies for animal tissues are invasive, prone to mechanical damage, and sensitive to chloride ion concentration, lacking real-time monitoring capabilities and biocompatibility.

Method used

An electrode array comprising an indicator electrode with a stainless steel wire coated with antimony, ruthenium(IV) oxide, or conductive polymer, and a reference electrode with a conductive polymer and ionic liquid-polyurethane membrane, designed for non-invasive attachment and independent of chloride concentration, integrated with a probe for real-time pH monitoring.

Benefits of technology

Enables precise, real-time pH measurement of animal tissues without disrupting tissue uniformity, reducing mechanical damage and chloride interference, and providing accurate pH readings.

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Abstract

The present invention relates to an electrode array (1) for measuring the pH of animal tissue, comprising an indicator electrode (2) and a reference electrode (3). The reference electrode (3) is all-solid and includes a steel wire (3a) having a coating layer (3b) of a conductive polymer and a membrane (3c) containing an ionic liquid and polyurethane. Further, the present invention relates to a probe (11) for real-time continuous pH measurement of animal tissue, comprising a main body (12) in the form of a mounting capsule in which the electrode array (1) according to the present invention, a vacuum system (13), and a temperature sensor (14) are housed. The vacuum system (13) is designed to attach the probe (11) to the tissue surface and includes a vacuum tube (13a) and a vacuum surface (13b), and the temperature sensor (14) is a contact sensor designed to be applicable to the surface of the tissue. Further, the present invention relates to an assembly (111) for measuring pH, comprising the probe (11) according to the present invention, a display device (17), and a calibration solution (24).
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