Deuterated polyunsaturated fatty acids or esters thereof for cosmetic applications

Abstract

To provide a cosmetic composition and a skin care product stabilized against lipid autoxidation.SOLUTION: Provided is a composition suitable for topical application comprising an effective amount of one or more deuterated polyunsaturated fatty acids or esters thereof, wherein the amount of said deuterated polyunsaturated fatty acids is sufficient to inhibit lipid autoxidation and thereby reduce skin damage.SELECTED DRAWING: None

Description

[Technical Field]

[0001] (Reference to Related Application) This patent application was filed under 35 U.S.C. § 119 on February 12, 2020. This application claims the benefit of priority to U.S. Provisional Application No. 975,543, filed on 2004-08-29 ... is fully incorporated herein by reference in its entirety for all purposes. (Technical field) The present invention relates to cosmetic compositions and skin care products stabilized against lipid autoxidation. In particular, the present invention relates to a method for converting a portion of the polyunsaturated fatty acids used in cosmetic compositions into the corresponding The fatty acids are replaced with deuterated polyunsaturated fatty acids. [Background technology]

[0002] (Technical level) Aging is the accumulation of physical changes over time that result from cumulative damage to tissues. This overwhelms the body's natural ability to repair tissue. For example, such damage can disrupt oxidative stress, a process that is crucial for cellular energy production. It is caused by reactive oxygen species (ROS), which are by-products of phosphorylation. ROS are involved in the production of cellular components. It oxidatively damages the cells, gradually leading to a decline in their function.

[0003] In particular, environmental (extrinsic) factors such as exposure to direct sunlight or smoking can cause aging, including skin aging. To address this, cosmetic skin compositions may These products are formulated as anti-aging creams and moisturizers to promote the youthful appearance of skin. To maintain the quality and / or make aging skin look younger and reduce the number of wrinkles This is encouraged.

[0004] The science of skin aging is a progressive physiological process that results in the loss of homeostatic capacity. Skin wrinkles are the result of structural changes in the dermis and subcutaneous tissue that lead to the formation of wrinkles. Scientifically, there are four main types of wrinkles, each of which develops in a specific area of ​​the skin: Atrophic crinkling rhytids, permanent elastic wrinkles (permanent elastotic creases), dynamic expression lines (dyna mic expression lines, and gravitational folds al folds.) Each type of wrinkle has its own set of potential applications for cosmetic and dermatological treatments. Respond differently.

[0005] Skin changes associated with advanced visual aging are recognized as a serious cosmetic problem. The salient features of the problem are several of the symptoms of skin aging, including discoloration, loss of texture / elasticity, and wrinkles. These and to some extent related cellulite are caused by the story symptoms. The phenomenon of formation is related to the structural and metabolic changes in connective tissue that are accelerated by ROS damage. Such aged skin appears to be significantly altered at the histological level. Oxidative stress also affects other factors related to skin health, such as sebum content, pH, and hydration. It also affects parameters, with lips being a particular example of the latter.

[0006] Exposure to sunlight leads to accelerated skin aging and photoaging. The main UV components are UVA (400-320 nm, transparent glass is in this range) and UVB ( 320~280nm; filtered by glass). , which contains 10 to 100 times more UVA than UVB, depending on environmental factors. The SPF sunscreen rating system is calibrated for UVB. B causes many skin cancers, but melanoma (formed B melanocytes) is a type of skin cancer. UVA rays penetrate deeper and reach the base of the epidermis, which contains melanocytes. At high latitudes, UVA levels do not decrease as much as UVB levels. Melanin provides UV protection. However, in the process, it is oxidized to form melanin radicals, which then generate other radicals. Redheads produce the reddish-yellow pigment pheomelanin, while blackheads produce They do not produce the brown pigment eumelanin, which can lead to the development of melanoma. Pheomelanin is the less stable of the two and is less likely to generate radicals. The photoaging process is also more likely to be due to oxidative damage caused by UV-generated ROS. Sunscreens block UV absorption and / or neutralize ROS. This reduces damage.

[0007] A characteristic odor is another feature associated with aging skin. Many animals have a distinct odor that is different between young and old. We rely on our sense of smell to distinguish between young and old people. A Japanese study reported that people over the age of 40 have an unpleasant "old-age odor." This is mainly due to oxidation products of unsaturated fatty acids such as nonenal. Studies have shown that older Americans have lower levels of nonenal (a compound known to have a "greasy" smell). This suggests that dietary differences between the Japanese and American diets may be due to the high cholesterol and lipid peroxide content of the blood. The Japanese population, primarily from a seafood-rich diet, has a much greater tendency to oxidize essential fatty acids. This was due to excessive ingestion.

[0008] Polyunsaturated fatty acids (PUFAs) play a major role in age-related skin changes. Fatty acids, the main components of lipid membranes, are the first line of defense against ROS attack. Peroxidized PUFAs cause various damages, producing reactive intermediates that alter the properties of lipid membranes. Initiates further oxidation chain reactions, leading to oxidative damage to proteins and DNA. and even mutagenesis (genomic aging) have been shown to be induced by lipid peroxidation. Furthermore, some of the PUFA oxidation products, such as nonenal (VS) and malondialdehyde, Some products cause cross-links in proteins and other cellular components (advanced glycation end products (AGEs)). They form and contribute to the accumulation of chemical debris (e.g., the age pigment lipofuscin) with age. Lipid peroxidation also plays a role in cancer-related neoplastic transformation. At the macro level, linoleic acid, and to a lesser extent linolenic acid, deficiency can lead to dry skin. It causes irritation of the skin, dermatitis, and massive transepidermal water loss.

[0009] Based on the above, topical cosmetic compositions that inhibit or prevent lipid autoxidation in skin layers are , providing significant inhibition of wrinkle formation and other features of aging skin. Summary of the Invention

[0010] The present invention inhibits lipid peroxidation, thereby enhancing its role as a driving component in aging skin. topical cosmetics formulated to reduce or prevent peroxidation, such as that causing wrinkles; The present invention relates to skin care compositions. Oxidative damage is almost always the same whether induced by ROS (indirectly generated) or ROS (indirectly generated). Particularly in the recognition that it occurs at a specific molecular site, namely the bis-allyl methylene group in fatty acids. This damage triggers a further damaging oxidative cascade. The important PUFAs (linoleic and linolenic acids) belong to the group of essential nutrients, i.e., they , which cannot be biosynthesized by humans and are provided through diet, skin absorption, or other exogenous administration. It must be.

[0011] The deuterated PUFAs contained in these topical compositions are incorporated into dermal cells, including cell membranes. This involves stabilizing these cells against lipid chain autooxidation. This, in turn, reduces damage to the skin resulting from such autoxidation, thereby This reduces the adverse cosmetic changes to the skin mentioned above. Unlike prior disclosures that provide a sufficient amount of hydroxybenzoates to be beneficial, the present invention provides a It relies on the direct absorption of deuterated PUFAs.

[0012] Based on the above, in one embodiment, the present invention provides an effective amount of one or more deuterated PUFAs. the deuterated PUFAs are effective in preventing lipid autoxidation and reducing the appearance of skin. The composition is sufficient to inhibit or prevent subsequent damage to the dermis of the skin. The deuterated PUFA used in Deuterated linolenic acid or its ester.

[0013] Fatty acids and mixtures of fatty acids, such as stearic acid, oleic acid, lauric acid, palmitic acid, Myristic acid and / or lactic acid are used in cosmetic and skin care products, e.g., creams, lotions, It is used in formulations such as ointments, ointments, emulsions, cakes, soaps, and pastes. This includes cosmetics, face creams, sunscreens, body creams, anti-aging creams, etc. Deuterated polyunsaturated fatty acids or esters are fatty acids, fatty acid esters, or natural oils. In any cosmetic composition or skin care product containing Fatty acids, fatty acid esters, or parts of natural oils are simply converted into deuterated polyunsaturated fatty acids or esters. In one embodiment, one or more deuterium a fatty acid, a fatty acid ester, or a fatty acid replaced by a substituted polyunsaturated fatty acid or ester; The amount of natural oil is based on the total weight of the fatty acids, fatty acid esters, and natural oils present in the composition. The range is about 0.1 to about 30 weight percent.

[0014] In another embodiment, the amount of deuterated polyunsaturated fatty acid or ester thereof present in the composition is About 0.1 to about 25 parts by weight based on the total weight of the fatty acids, fatty acid esters, and natural oils used In another embodiment, a deuterated polyunsaturated fatty acid or ester thereof is used. based on the total weight of the fatty acids, fatty acid esters, and natural oils present in the composition, It ranges from 0.1 to about 20 weight percent.

[0015] In yet another embodiment, the present invention provides a method for reducing skin breakdown in a patient's skin. The method comprises providing a cosmetic or skin care composition comprising an effective amount of one or more deuterated PUFAs. in an amount sufficient to inhibit or prevent lipid autoxidation and subsequent damage to the dermis of the skin. applying the deuterated PUFA to the skin; and allowing at least a portion of the deuterated PUFA to adsorb to the skin. Such a method may be used to attenuate the odor of aged skin. It is possible.

[0016] In one preferred embodiment, the deuterated fatty acid or ester is 11,11-D2- Linoleic acid or esters; or 8,8,11,11-D4-linoleic acid or esters or 11,11-D2-linolenic acid or ester; or 11,1 1,14,14-linolenic acid or ester, optionally with additional amino acids elsewhere in the molecule It has deuteration. DETAILED DESCRIPTION OF THE INVENTION

[0017] The present invention provides cosmetic compositions and skin care products stabilized against lipid autoxidation. Specifically, the present invention stabilizes the dermis against lipid autoxidation by using these compositions. The present invention provides a portion of a deuterated polyunsaturated fatty acid or ester in a composition product.

[0018] However, prior to describing this invention in further detail, the following terms will first be defined.

[0019] The term "bis-allylic position" refers to the position of two vinyl groups (i.e., -CH=CH-CH-C It refers to the hydrogen and carbon atoms located between the carbon atom and the hydrogen atom (H=CH2-).

[0020] The term "lipid autoxidation" refers to the well-known process of polyunsaturated fatty acid peroxidation. When the first polyunsaturated fatty acid is oxidized by ROS, other fatty acids in the lipid membrane are oxidized. This occurs when a cascade of further oxidation of the polyunsaturated fatty acid groups occurs. ROS are generated first through the oxidation of polyunsaturated fatty acids via a free radical mechanism, and then oxidize adjacent polyunsaturated fatty acids in phospholipids via the same free radical mechanism. and then, in a process called lipid chain autoxidation, another adjacent polyunsaturated fatty acid can be bound to another The resulting damage can be, for example, in cell membranes. Among the phospholipid components found are a significant number of oxidized polyunsaturated fatty acids.

[0021] As used herein, the term "linoleic acid" has the chemical formula provided below: Compounds having a natural abundance of deuterium at each hydrogen atom and pharmaceutically acceptable salts thereof Points: [ka]

[0022] Linoleic acid has a single bis-allyl methylene group at carbon 11. An ester is formed by replacing an -OH group with -OR. Such an ester is , as defined herein below.

[0023] As used herein, the term "linolenic acid" refers to a compound having the chemical formula provided below. and a compound having a natural abundance of deuterium at each hydrogen atom and a pharmaceutically acceptable salt thereof. Salt refers to: [ka]

[0024] Linolenic acid has two bis-allylmethylene groups at carbons 11 and 14. Esters of acids are formed by replacing the -OH group with -OR. Stell is as defined herein below.

[0025] As used herein, arachidonic acid is a nucleotide that is a part of the amino acid sequence of the amino acid sequence. Has: [ka]

[0026] Arachidonic acid has three bis-allyl methylene groups at carbons 7, 10, and 13. Esters of norenic acid are formed by replacing the -OH group with -OR. Such esters are as defined herein below.

[0027] The term "deuterated polyunsaturated fatty acids" refers to fatty acids in which the methylene groups found in the bis-allylic positions are at least At least one hydrogen atom is replaced by a deuterium atom, and optionally other positions in the molecule are non- It refers to the well-known PUFAs that have exchangeable deuterium atoms. Saturated fatty acids are 13 C-substituted bis-allylic position 12 C. Suitable deuterated PUFAs include deuterated linoleic acid and its esters; deuterated linolenic acid and its esters; and highly deuterated PUFAs such as deuterated arachidonic acid. do.

[0028] As used herein, and unless the context dictates otherwise, the term "deuterated linoleic acid" refers to The "acid or ester thereof" refers to a compound having at least one substituted allylic group in the methylene group found in the bis-allylic position. A linear molecule having hydrogen atoms and optionally additional non-exchangeable deuterium atoms at other positions in the molecule. Specific compounds included in this definition include but are not limited to: Examples include 11-D1-linolenic acid, 11,11-D2-linolenic acid, and 11,14-D 2-Linolenic acid, 14-D1-Linolenic acid, 14,14-D2-Linolenic acid, 11,11 ,14-D3-linolenic acid, 11,14,14-D3-linolenic acid, 11,11,14, 14-D4-linolenic acid, and perdeuterated linoleic acid.

[0029] As used herein, and unless the context dictates otherwise, the term "deuterated linoleic acid" refers to a compound selected from the group consisting of linoleic acid, ... The "acid or its ester" is a methylene group found in one of the two bis-allylic positions in the molecule. at least one deuterium atom in the group and, optionally, additional non-exchanged atoms elsewhere in the molecule. Linolenic acid or ester compounds containing a replaceable deuterium atom are included in this definition. Examples of such compounds include, by way of example only, 11-D1-linoleic acid, 11,11-D2 -Linoleic acid, 8,11-D2-linoleic acid, 8,11,11-D3-linoleic acid, 8, 8,11-D3-linoleic acid, 8,8,11,11-D4-linoleic acid, and perdeuterated Linoleic acid is one example.

[0030] As used herein, and unless the context dictates otherwise, the term "deuterated arachidonic acid" refers to a compound selected from the group consisting of arachidonic acid, ... "phosphoric acid or its ester" has at least one heavy water atom in a bis-allylic position elsewhere in the molecule. Arachidonic acid or esterified arachidonic acid having an oxygen atom and optionally an additional non-exchangeable deuterium atom Specific compounds encompassed by this definition include, by way of example only, 7,7-D 2-Arachidonic acid, 10,10-D2-arachidonic acid, acid, 13,13-D2-arachidonic acid Arachidonic acid, 7,7,10,10-D4-arachidonic acid, 7,7,13,13-D4-arachidonic acid Arachidonic acid, 10,10,13,13-D4-arachidonic acid, 7,7,10,10,13,13 -D6-arachidonic acid and per-deureated arachidonic acid.

[0031] As used herein, the term "ester" refers to any pharmaceutically acceptable salt of a deuterated PUFA. Acceptable esters include, but are not limited to, C1-C6 alkyl esters, glycero glycerides (including monoglycerides, diglycerides and triglycerides), sucrose esters, The particular ester used may be selected from the group consisting of phosphate esters, esters of hydroxybenzoates, etc. ... It is not critical as long as the material is biocompatible (non-toxic and biocompatible).

[0032] As used herein, the term "phospholipid" refers to any and all lipids that are components of dermal cells. This term refers to all phospholipids, including phosphatidylcholine, phosphatidylethanolamine, and phospholipids. These include amino acids, phospholipids ... It is particularly rich in phospholipids containing oleic acids.

[0033] The term "non-exchangeable" means that exchange of one molecule with another occurs through hydrogen bonding interactions. This refers to the bonding of a deuterium atom to a carbon atom, which can be exchanged. Examples of exchangeable hydrogen / deuterium atoms are: Shown below. [ka]

[0034] Here, the carboxylic acid protons of propionic acid undergo hydrogen bond exchange, but the methylene water The hydrogens and methyl hydrogens are not, and therefore exchangeable with D2O.

[0035] The term "natural oil" refers to well-known oils such as coconut oil, olive oil, sunflower seed oil, etc. This refers to essential oils such as lemon oil, lavender oil, and cinnamon oil. Their use in cosmetic and skin care products is well known.

[0036] The term "skin care products" includes creams, lotions (including emulsions), ointments, whether in the form of paste, thixotropic composition, soap, emollient, etc. It refers to any topical product that is applied to the skin primarily for dermatological (medicinal) purposes. Such dermatological purposes include, but are not limited to, rashes, dry skin, scratching, These include treating wounds, cuts, bruises, acne, facial hair, dermatitis, and hair loss.

[0037] The term "cosmetics" includes creams, lotions (including emulsions), ointments, pastes, Whether in the form of a spray, thixotropic composition, emollient, etc. It refers to any topically applied product that is applied to the skin primarily for cosmetic purposes. Purposes include concealing aging spots, treating or preventing wrinkles, and using it as makeup. To apply, to hide bruises or scratches, to moisturize skin, for facial cleansing Cosmetic uses include, but are not limited to, use as a face mask or mask. .

[0038] As used herein, the term "patient" refers to a patient who is topically applying a cosmetic or skin care composition. Refers to the person who intends to apply it.

[0039] As used herein, the term "effective amount" refers to the amount of ROS produced in the dermal layer of a patient. "Inhibition of or prevention of lipid autoxidation" refers to an amount of the composition of the present invention sufficient to inhibit or prevent lipid autoxidation.

[0040] In some cases, the composition is used as a skin care product and / or a cosmetic. However, for purposes of this application, the primary use of the product is Determine whether the product is a cosmetic or skin care product.

[0041] Preparation of compounds Deuterated PUFAs are disclosed in many references and / or are commercially available. For example, 11-D1-linoleic acid, 11,11-D2-linoleic acid, 8,8,11,11 -D4 linoleic acid, 11,11-D2 linolenic acid, 11,11,14,14-D4 linoleic acid Nolenic acid and other deuterated PUFAs are described, for example, in U.S. Pat. Nos. 10,052,299 and 1 See US Pat. No. 6,730,821. Additionally, 11-D1-linoleic acid is available from Cayman Chemical Company,Ann Arbor,Michigan,USA 48108. In addition, 7,7-D2-arachidonic acid, 10,10- D2-arachidonic acid, 13,13-D2-arachidonic acid, 7,7,10,10-D4-arachidonic acid Arachidonic acid, 7,7,13,13-D4; Arachidonic acid, 10,10,13,13-D4 -Arachidonic acid, 7,7,10,10,13,13-D6-arachidonic acid, is a pinov et al., Molecules, 28(12):3331 et seq. (2 Other deuterated arachidonic acid compounds are known in the art. do.

[0042] These esters of deuterated fatty acids are prepared by conventional techniques well known in the art. can be.

[0043] composition The compositions described herein include any one suitable for topical application to the skin, including any one of the following: Described:

[0044] Creams are spreadable, topically applied compositions containing approximately equal parts water and oil. The latter includes fatty acids, etc. Cream is a conventional product and is not a product of the present invention. In fact, certain high-end skin care products contain less saturated fat than the The lotion is a subclass of the cream. It is less viscous due to the addition of more water and is therefore easier to apply to the skin. It is distinguished from being somewhat easier.

[0045] Ointments are also topical compositions that can be applied, but contain approximately four times as much oil as water. Ointments are also well known in the art. Pastes differ from creams in that they are Another form of cellulose, but with large amounts of finely divided solids such as starch, zinc oxide, and calcium carbonate Contains:

[0046] Emollients are compositions that are designed to moisturize the skin and are applied to the skin to Soothes and hydrates skin.

[0047] Nebulization is well known in the art and preferably produces a discernible film after evaporation of the solvent. It is a film-forming spray that provides a film.

[0048] Generally, the compositions described herein include an oily composition comprising: a) Approximately 1% to 99% deuterated P as an essential lipid component for primary ROS protection oils containing UFAs; b) at least one wettable powder; and c) Balance of deionized water.

[0049] Preferably, the deuterated PUFA is deuterated linoleic acid or an ester thereof. The specific amount of deuterated PUFAs stabilizes cell membranes in the dermis against degradation by ROS. Generally, the entire composition contains at least about 100% by weight of the total composition. Also contains about 0.5% deuterated PUFA, preferably about 1% deuterated PUFA.

[0050] Additionally, the optional ingredients may contain one or more common ingredients such as fragrance, regulators of lipid metabolism, antioxidants, etc. Additives include: Suitable hydrating agents include vegetable glycerin, aloe vera, and grape seed oil. Other vegetable oils, such as vitamin E oil, jojoba oil, linseed oil, primrose oil or any Other plant essential oils may be included, each used in their conventional amounts.

[0051] In some embodiments, the compositions disclosed herein may be used in combination with one or more cosmetic products. May contain ingredients. CTFA International Cosmetic Ingredient Dictionary and Handbook(2004 and above) and 2008) describe a wide variety of non-limiting cosmetic products that can be used in the compositions disclosed herein. Examples of these ingredient classes include: fragrances additives (artificial and natural), dyes and colorings (e.g., Blue 1, Blue 1 Lake ke), Red 40, Titanium dioxide, D&C Blue No. 4, D&C Green No. 5. D&C orange no.4, D&C red no.17, D&C red no .33, D&C Violet No. 2, D&C Yellow No. 10, D&C Yellow No. 11), adsorbents, lubricants, solvents, moisturizers (e.g., emollients, moisturizers, skin Film-forming agents, occlusive agents, agents that affect the skin's natural moisturizing mechanism, water repellents, UV absorbers Physical and chemical properties of antibacterial agents such as paraaminobenzoic acid ("PABA") and the corresponding PABA derivatives absorbents, titanium dioxide, zinc oxide, etc.), essential oils, vitamins (e.g. A, B, C, D, E, K), trace metals (e.g., zinc, calcium, selenium), anti-irritants (e.g., steroids, nonsteroidal anti-inflammatory drugs), plant extracts (e.g., aloe vera, duck Mile, cucumber extract, ginkgo biloba, ginseng, rosemary), antibacterial agents, antioxidants (e.g. BHT, tocopherol), chelating agents (e.g., EDTA disodium, EDTA tetrasodium), preservatives (e.g., methylparaben, propylparaben), pH adjusters ( sodium hydroxide, citric acid), absorbents (e.g., aluminum octenyl succinate), Um, kaolin, corn starch, oat starch, cyclodextrin, talc, Zeo Light), skin bleaching and whitening agents (e.g., hydroquinone, niacinamide lactate), moisturizing Agents (sorbitol, urea, mannitol, etc.), exfoliants, waterproofing agents (magnesium stearate) Sodium / aluminum hydroxide, etc.), skin conditioning agents (aloe extract, alanine Toin, bisabolol, ceramide, dimethicone, hyaluronic acid, dipotassium glycyrrhizinate Some non-limiting examples of such ingredients are listed in the subsections below. It has been done.

[0052] In some embodiments, the compositions disclosed herein comprise one or more UV absorbers. UV absorbing agents that can be used in combination with the compositions disclosed herein Sorbents include chemical and physical sunblocks. Chemical sunblocks that can be used include: Non-limiting examples include para-aminobenzoic acid (PABA), PABA esters (glyceryl esters), Dimethyl PABA, Amyl dimethyl PABA, Octyl dimethyl PABA, Butyl PABA, Ethyl PABA, ethyl dihydroxypropyl PABA, benzophenones (oxyben benzophenone, sulisobenzone, benzophenone, benzophenone-1 to 12), cinnamic acids ( Octyl methoxycinnamate, isoamyl p-methoxycinnamate, octyl methoxycinnamate le, cinoxate, diisopropylmethyl cinnamate), DEA-methoxycinnamate, Diisopropyl cinnamate ethyl, octanoic acid glyceryl dimethoxycinnamate, Toxiccinnamate ethyl), cinnamate ester, salicylate (fomethicone salicylate) salicylate, benzyl salicylate, glycol salicylate, isopropyl benzyl salicylate, etc. ), anthranilate, ethyl urocanate, homosalate, octisalate, dibenzo Ilmethane derivatives (such as avobenzone), octocrylene, octyltriazone, trio Digalloyl leate, glyceryl aminobenzoate, dihydroxyacetone-containing Lawsone, Ethylhexyl triazone, dioctyl butamine triazone, benzylidene malonate Polysiloxane, terephthalidene dicamphorsulfonate, phenyl dibenzimidazole Disodium tetrasulfonate, diethylaminohydroxybenzoylhexyl benzoate , bisdiethylaminohydroxybenzoyl benzoate, dibenzimidazole benzoate, Bisdiethylaminohydroxybenzoyl benzoate, diethylaminohexyl benzoate, Benzoic acid bisdiethylamino wax, bisbenzoxazoylphenylethylhexyl Iminotriazine, Drometrizole Trisiloxane, Methylenebisbenzotriazolyl Tetramethylbutylphenol and bisethylhexyloxyphenol methoxyphenol Nyltriazine, 4-methylbenzyldecane, and 4-methoxycinnamate iso Non-limiting examples of physical sunscreens include kaolin, talc, pentyl Examples of suitable anti-inflammatory agents include hydroxybenzoates, hydroxybenzoates, and metal oxides such as titanium dioxide and zinc oxide. The light composition may have UVA and UVB absorbing properties. , 56, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90 or more, or any integer therein can have a derivative sun protection factor (SPF).

[0053] In some embodiments, the compositions disclosed herein include one or more moisturizing agents. Non-limiting examples of moisturizers that can be used with the compositions of the present invention include: Contains amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, Glucose, glycerin, glycerol polymer, glycol, 1,2,6-hexanediol Lithium, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol , lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-1 5-Butanediol, Polyglyceryl Sorbitol, Salt of Pyrrolidone Carboxylic Acid, Potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol Examples of sugars that can be used include sucrose, trehalose, urea, and xylitol.

[0054] Further examples include acetylated lanolin, acetylated lanolin alcohol, and alanine. , Algae Extract, Aloe Barbadensis, Aloe Barbadensis Gel, Althea Officinalis Cinnaris Extract, Apricot Kernel Oil, Arginine, Arginine Aspartate, Arnica Montana Extract, Aspartic Acid, Avocado (Persea Gratissima) Oil, Bariatric Glycosphingolipids , butyl alcohol, beeswax, behenyl alcohol, β-sitosterol, birch ( betula alba bark extract, borage (borago officinalis) ) Extract, Butcher's Broom (Ruscus aculeatus) Extract, Butylene Glycol, Calendula Extract, Calendula Officinalis Oil. Candelilla (euph orbia cerifera wax, canola oil, caprylic / capric triglyceride Celite, cardamom (elettaria cardamomum) oil, carnauba (c opernicia cerifera wax, carrot (daucus carrot) ota sativa (Castor) oil, ricinus communis (Castor) oil, ceramide , Ceresin, Cetearis-5, Cetearis-12, Cetearis-20, Ceteareth Octanoate Cetyl, Ceteth-20, Ceteth-24, Cetyl Acetate, Cetyl Octanoate, Cetyl Palmitate chamomile oil, cholesterol, cholesterol esters, hydroxystearic acid Cholesterol, Citric Acid, Clary (Salvia Sclarea) Oil, Cocoa Butter, Cocoa Pyrric / Capric Acid, Coconut Oil, Collagen, Collagen Amino Acids, Corn Oil yl, fatty acids, decyl oleate, dimethicone copolyol, dimethiconol, adipine Dioctyl Succinate, Dioctyl Succinate, Dipentaerythritol Hexacaprylate / Hexacaprylate Lactoate, DNA, Erythritol, Ethoxydiglycol, Ethyl Linoleate, Eucalyptus Globulus oil, evening primrose (oenothera biennis) oil, fatty acids, geranium Maculatum oil, glucosamine, glucose glutamate, glutamic acid, glycerin 26, Glycerin, Glycerol, Glyceryl Distearate, Hydroxystearic Acid Glyceryl, Glyceryl Laurate, Glyceryl Linoleate, Glyceryl Myristate, Glyceryl oleate, glyceryl stearate, glyceryl stearate SE, glyceryl Cerol, Glyceryl-25, Glycerin-26, Glycerin-25, Glyceryl-25 , Glyceryl-25, Glyceryl-26, Glyceryl-25 Glyceryl Stearate, Glyceryl stearate SE, glycine, glycol stearate, glycosaminoglycans Grape (Vitis vinifera) seed oil, Hazel (Corylus amylase) ericana) nut oil, hazel (corylus avellana) nut oil, Hexylene glycol, hyaluronic acid, hybrid safflower (carthamus tinctorius) oil, hydrogenated castor oil, hydrogenated cocoglycerides, hydrogenated coco Cornstarch oil, hydrogenated lanolin, hydrogenated lecithin, hydrogenated palm glycerides, hydrogenated palm kernel Oil, hydrogenated soybean oil, hydrogenated tallow glyceride, hydrogenated vegetable oil, hydrolyzed collagen, hydrolyzed Elastin, hydrolyzed glycosaminoglycan, hydrolyzed keratin, hydrolyzed soy protein , Hydrolyzed Lanolin, Hydroxyproline, Isocetyl Stearate, Stearoyl Stearate Isocetyl oleate, isodecyl oleate, isopropyl isostearate, lanolin Isopropyl myristate, isopropyl palmitate, stearic acid Isopropyl, Isostearamide DEA, Isostearic Acid, Isostearyl Lactate, Neo Isostearyl pentanoate, Jasmine (Jasminum officinale) oil, jojoba (buxus chinensis) oil, kelp, kukui (aleur ites moluccana) Nut Oil, Lactamide MEA, Laneth 16, Laneth 10 Acetate, Lanolin, Lanolin Acid, Lanolin Alcohol, Lanolin Oil, Lanolin Water Lavender (lavandula angustifolia) oil, lecithin Lemon (citrus medica limonum) oil, linoleic acid, linoleic oleic acid, macadamia nut oil, maltitol, matricaria (chamomilla recutita) oil, methyl glucose sesquistearate, methylsilanol PCA, mineral oil, mink oil, Mortierella oil, myristyl lactate, Myristyl myristate, myristyl propionate, neopentyl glycol dicaprylate Dicaprate, Octyldodecanol, Octyldodecyl myristate, Stearin Octyl hydroxystearate, octyl palmitate, octyl salicylate Chill, Octyl Stearate, Oleic Acid, Olive (Olea Europaea) Oil. Orange (citrus aurantium dulcis) oil, palm (ela eis guineensis) oil, palmitic acid, pantethine, panthenol, Dimethyl ethyl ether, paraffin, PCA, peach (prus persica) carne Peanut (arachis hypogaea) oil, PEG-8 C1 2-18 ester, PEG-15 cocamidopropyl betaine, PEG-150 distearate, PEG-60 Glyceryl Stearate, PEG-5 Glyceryl Stearate, Stearyl PEG-30 Glyceryl Phosphate, PEG-7 Hydrogenated Castor Oil, PEG-40 Hydrogenated Castor Oil, P EG-60 Hydrogenated Castor Oil, PEG-20 Methyl Glucosesquistearate, PEG4 0 Sorbitan Peoleate, PEG-5 Soy Sterols, PEG-10 Soy Sterols, P EG-2 Stearate, PEG-8 Stearate, PEG-20 Stearate, PEG- 32 Stearate, PEG-40 Stearate, PEG-50 Stearate, PEG-1 00 Stearate, PEG-150 Stearate, Pentadecalactone, Peppermint Oil , Petrolatum, Phospholipids, Polyamino Acid Saccharides, Polyglyceryl-3 Diisostearate , Polyquaternium-24, Polysorbate 60, Polysorbate 20, Polysorbate 40, Polysorbate, Polysorbate 60, Polysorbate 80, Polysorbate 85 , potassium myristate, potassium palmitate, propylene glycol, dicaprylic acid Propylene glycol / dicaprate, propylene glycol dioctanoate, dipelargo Propylene glycol phosphate, propylene glycol laurate, propylene stearate Glycol, Propylene Glycol Stearate SE, PVP, Pyridoxine Dipalmate Glutamate, Retinol, Retinyl Palmitate, Rice Bran Oil, RNA, Rosemary Oil, Rose Oil, safflower oil, sage oil, sandalwood (santalum album) oil, phosphorus , serum protein, sesame (samum indicum) oil, celery (serine), Serum proteins, sage (Salvia officinalis) oil, sandalwood Santalum album oil, serine, serum protein, sesame (sesame) amum indicum) oil, shea butter, silk powder, chondroitin sulfate Sodium, Sodium Hyaluronate, Sodium Lactate, Sodium Palmitate, PC Sodium A, sodium polyglutamate, water-soluble collagen, sorbitan laurate , sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate, stearyl alcohol Sorbitan phosphate, sorbitol, soybean (glycine soja) oil, sphingolipids, Walnut, squalene, stearic acid amide, stearic acid, stearoxy dimethicone, squalane Tearoxyltrimethylsilane, stearyl alcohol, stearyl glycyrrhetinate, Stearyl butanoate, stearyl stearate, sunflower seed oil, sweet almond ( prunus amygdalus dulcis) oil, synthetic beeswax, tocopherol , Tocopheryl Acetate, Tocopheryl Linoleate, Triphenine, Tri Neopentanoate Decyl, Tridecyl Stearate, Triethanolamine, Tristearin, Urea, Plant Oil, water, wax, wheat (triticum vulgare) endosperm oil, ylang-ylang (ca Contains nanga odorata oil.

[0055] In some embodiments, the compositions disclosed herein may include one or more antioxidants. Non-limiting examples of antioxidants that can be used with the compositions include acetyl Cysteine, ascorbic acid polypeptide, ascorbyl dipalmitate, pectic acid methyl Tyrsilanol ascorbyl, ascorbyl palmitate, ascorbyl stearate, BHA, BHT, t-butylhydroquinone, cysteine, cysteine ​​HCl, diacyl hydroxybenzoate Hydroquinone, di-t-butylhydroquinone, dicetyl thiodipropionate, dioleyl Copherylmethylsilanol, disodium ascorbyl sulfate, disodium thiodipropionate Tearyl, ditridecyl thiodipropionate, dodecyl gallate, erythorbic acid, asparagus Corbic acid ester, ethyl ferulate, ferulic acid, gallic acid ester, hydroxy Non, isooctyl thioglycolate, kojic acid, magnesium ascorbate, ascorbyl palmitate Magnesium pyruvylphosphate, methylsilanol ascorbate, green tea and grape seed extract Natural plant antioxidants such as nordihydroguaiaretic acid, octyl gallate, phenoxyethanol, Nylthioglycolic acid, potassium tocopheryl phosphate, potassium sulfite, gall Propyl acetate, quinones, rosmarinic acid, sodium ascorbate, sodium bisulfite , Sodium erythorbate, Sodium metabisulfite, Sodium sulfite, Superoxide oxide dismutase, sodium thioglycolate, sorbityl furfural, Odiglycol, thiodiglycolamide, thiodiglycolic acid, thioglycolic acid, Lactic acid, thiosalicylic acid, tocophereth 5, tocophereth 10, tocophereth 12, tocophereth Tocophereth 18, Tocophereth 50, Tocopherol, Tocopheran, Tocopheryl Acetate, Tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, tris(no (phenylphenyl) phosphite.

[0056] In some embodiments, the compositions disclosed herein may include one or more structuring agents. In certain embodiments, the structuring agent may be added to the composition to contribute to its stability. In other embodiments, the structuring agent is an emulsifier or surfactant. Non-limiting examples of structuring agents include stearic acid, palm oil, and the like. Mitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearin acid, palmitic acid, stearyl alcohol having an average of about 1 to about 21 ethylene oxide units polyethylene glycol ethers having an average of about 1 to about 5 ethylene oxide units; polyethylene glycol ethers of cetyl alcohol, and mixtures thereof. do.

[0057] In some embodiments, the compositions disclosed herein include one or more emulsifiers. Emulsifiers reduce the interfacial tension between the phases, improving the formulation and stability of emulsions. Emulsifiers include nonionic, cationic, anionic, and zwitterionic emulsifiers. (McCutcheon's (1986); U.S. Pat. No. 5,011,681 ;4,421,769;3,755,560). Non-limiting examples include glycerin esters. esters, propylene glycol fatty acid esters, polyethylene glycol fatty acid esters esters, fatty acid esters of polypropylene glycol, esters of sorbitol, sorbitol anhydride Esters of vitamins, esters of carboxylic acid copolymers, esters of glucose and ethers ethoxylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene Diethylene fatty ether phosphate, fatty acid amide, acyl lactylate, soap, TE A stearate, DEA oleth-3 phosphate, polyethylene glycol 20 sorbitan Monolaurate (Polysorbate 20), Polyethylene Glycol 5, Soybean Sterols, Steareth-2, Steareth-20, Steareth-21, Ceteareth-20, PPG-2 Methyl glucose ether distearate, ceteth-10, polysorbate 80, cetyl Phosphate, Potassium Cetyl Phosphate, Diethanolamine Cetyl Phosphate, Polysorbate 60, glyceryl stearate, PEG-100 stearate, and Examples of the mixture include:

[0058] In some embodiments, the compositions disclosed herein may comprise one or more silicone-containing compounds. In a non-limiting embodiment, the silicone-containing compound may have a molecular skeleton of Polymers composed of alternating silicon and oxygen atoms with side groups attached to the silicon atoms - may include any member of the family of products. - Si-O- chain length, side groups, By varying the crosslinking and polymerization, silicones can be synthesized into a wide variety of materials. They may vary in consistency from liquid to gel to solid. Silicone-containing compounds that can be used in the present invention include those described herein or Non-limiting examples include silicone oils (e.g., volatile and non-volatile oils), gels, and solids. In certain embodiments, the silicon-containing compound is Silicone oils such as polyorganosiloxanes include, but are not limited to, polyorganosiloxanes. Examples include dimethicone, cyclomethicone, polysilicone-11, and phenyl trimethicone. silane, trimethylsilylamodimethicone, stearoxytrimethylsilane, or these and other The present invention relates to a mixture of organosiloxane materials in any given ratio, and is suitable for the intended use (e.g., to achieve the desired consistency and application characteristics depending on the application area (e.g., skin, hair, or specific areas such as eyes). "Volatile silicone oil" has a low heat of vaporization, i.e., usually 1 g of silicone oil Contains a silicone oil having less than about 50 calories per gram. Non-limiting examples include Dow Corning 344 Fluid, Dow Corn ing 345 Fluid, Dow Corning 244 Fluid, and Do w Corning 245 Fluid, Volatile Silicon 720 7 (Union Carbide Corp., Danbury, Conn.) and other Chlomethicone; low viscosity dimethicone, i.e., dimethicone having a viscosity of about 50 cst or less (For example, Dow Corning 200-0.5 cst Fluid, etc.) Dow Corning Fluids is a Available from Cyclomethicone Corporation, Midland, MI. Dimethicone and dimethicone are listed in the CTFA Cosmetic Ingredients Dict. nary, 3rd Edition (incorporated herein by reference), describes cyclic dimethylpolysiloxanes. Fully methylated linear endblocked with silane and trimethylsiloxy units The compositions herein are described as mixtures of siloxane polymers. Other non-limiting volatile silicone oils that may be used include General Elect ric Co,Silicone Products Div.,Waterford, S of NY and Stauffer Chemical Co, Adrian, Mich. These include those available from WS Silicones Div.

[0059] In some embodiments, the compositions disclosed herein may comprise one or more essential oils. Essential oils include oils derived from herbs, flowers, trees, and other plants. The oil is typically present as tiny droplets between plant cells and can be extracted in several ways known to those skilled in the art. methods (e.g., steam distillation, enflurage (i.e., extraction with fat), maceration, solvent These types of oils can be extracted by airborne methods (extraction, or mechanical compression). When exposed, they tend to evaporate (i.e., are volatile oils). Essential oils are colorless, but may oxidize and darken with age. Essential oils are insoluble in water. It is soluble in alcohol, ether, fixed oils (vegetable), and other organic solvents. Typical physical properties found in essential oils include a boiling point in the range of about 160°C to 240°C and a Densities range from 0.759 to about 1.096. Essential oils are typically found in They are named after the plant they come from. For example, rose oil and peppermint oil come from the rose plant and Derived from the peppermint plant. Non-limiting essential oils that can be used in the context of the present invention Typical examples are sesame oil, macadamia nut oil, evening rose oil, Spanish rosemary, berry oil, coriander oil, thyme oil, pimento berry oil, rose oil, balsamot oil, Rosewood oil, cedar oil, sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil , Frankincense oil, Gerania spinosa oil, Grapefruit oil, Jasmine oil, Lavender oil , lemon oil, lemongrass oil, marjoram oil, miller oil, orange oil, Patchouli oil, pepper oil, pepper oil, petitgrain oil, pine oil, rosemary oil, sun Dalwood oil, spearmint oil, vetiver oil, wintergreen oil, or ylang ylang Other essential oils known to those skilled in the art are also contemplated as useful within the context of the present invention. .

[0060] In some embodiments, the compositions disclosed herein include one or more thickening agents. Thickeners, including thickeners or gelling agents, can increase the viscosity of the composition. Thickening agents include substances that can be used to thicken the composition without substantially altering the efficacy of the active ingredients in the composition. Thickeners also include those capable of increasing the viscosity of the composition. In certain embodiments of the present invention, the thickener may be: Examples include hydrogenated polyisobutene or trihydroxystearin, or a mixture of both. Non-limiting examples of additional thickeners that can be used in the context of the present invention include: are carboxylic acid polymers, cross-linked polyacrylate polymers, and polyacrylamide polymers. Examples of carboxylic acid polymers include acrylic acid, substituted acrylic acid, polysaccharides, and gums. Derived from acrylic acid and the salts and esters of these acrylic and substituted acrylic acids The crosslinking agent may be a compound containing one or more monomers that are crosslinked with two or more carbon- They contain carbon-carbon double bonds and are derived from polyhydric alcohols (U.S. Pat. No. 5,087,445 No. 4,509,949; No. 2,798,053; CTFA Interna tional Cosmetic Ingredient Dictionary,Fo (See the Third Edition, 1991, pp. 12 and 80). Examples of carbonate polymers that have been used include ethers of acrylic acid and sucrose or pentachlorothiazolinone. Carbomers (e.g., BF Goodrich's carbomers), which are homopolymers of allylic acids crosslinked with Carbopol® 900 series. Cross-linked polyacrylate polymers Non-limiting examples of polymers include cationic and nonionic polymers. U.S. Patents 5,100,660; 4,849,484; 4,835,206; 4,628 ,078;4,599,379. Polyacrylamide polymers (substituted branched or unbranched poly Non-limiting examples of polyacrylamide polymers (including nonionic polyacrylamide polymers containing mers) include poly acrylamide, isoparaffin and laureth-7, acrylamide and acrylic acid and and multiblock copolymers of substituted acrylamide and substituted acrylic acid. Non-limiting examples of sugars include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl Hydroxymethylcellulose, methylhydroxyethylcellulose, microcrystalline cellulose, sulfur Other examples include cellulose polymers, sodium cellulose, and mixtures thereof. The hydroxy group of the hydroxypropylation to form hydroxyalkylated cellulose, and then the ether bond is removed. Alkyl-substituted cellulose further modified with C10-C30 linear or branched alkyl groups via Typically, these polymers are C with hydroxyalkyl cellulose. Other useful polysaccharides include ethers of C10 to C30 straight or branched chain alcohols. A sequence containing a linear chain of (1-3) linked glucose units with (1-6) linked glucose units per Non-limiting examples of gums that can be used with the present invention include cleroglucan. Acacia, agar, alginic acid, ammonium alginate, ammonium alginate , calcium alginate, calcium alginate, carrageenan, carrageenan, dextrin Ingredients: gelatin, gelatin gum, guar gum, guar hydroxypropyltrimonium chloride Lid, Hectorite, Hyaluronic Acid, Hydrated Silica, Hydroxypropyl Chitosan, Hydroxypropyl Oxypropyl guar, karaya gum, kelp, locust bean gum, nut gum, alginic acid Potassium, potassium carrageenan, propylene glycol alginate, hardened gum, carboxylate Dimethyldextran sodium, carrageenan, tragacanth gum, xanthan gum, and Mixtures of these may be mentioned.

[0061] In some embodiments, the compositions disclosed herein include one or more preservatives. Non-limiting examples of preservatives that can be used in the context of the present invention include: Polyquaternium-1 and benzalkonium halides (e.g., benzalkonium chloride ( "BAC") and benzalkonium bromide), parabens (e.g., methylparaben and pro Pyrilparaben), phenoxyethanol, benzyl alcohol, chlorobutanol, phenoxyethanol Quaternary ammonium antibacterial agents such as ethanol, sorbic acid, thimerosal, or combinations thereof Preservatives include:

[0062] In some embodiments, the compositions disclosed herein contain one or more additional pharmaceutical ingredients. Non-limiting examples of pharmaceutical ingredients / active agents include anti-acne agents, rosacea agents, Drugs used in the treatment of rheumatoid arthritis, analgesics, anesthetics, painkillers, antihistamines, nonsteroidal antihistamines Anti-inflammatory agents, including inflammatory agents, antibiotics, antifungals, antivirals, antibacterial agents, anticancer agents, scabicides , anti-androgenic agent, antiperspirant, antipruritic, antiseborrheic, bioactive proteins and peptides, burn treatment agents, cauterizing agents, bleaching agents, depilatories, diaper rash treatment agents, enzymes, hair growth promoters, hair growth retardants (D FMO and its salts and analogues), hemostatic agents, keratolytic agents, stomatitis treatment agents, cold sensitivity treatment agents, Dental and periodontal disease treatments, photoactivators, skin protection and barrier agents, hormones and adrenal cortical hormones Steroids such as steroids, sunburn treatments, sunscreens, transdermal active agents, nasal active agents , vaginally absorbed active agents, wart treatment agents, wound treatment agents, etc.

[0063] method The method of the present invention comprises periodically applying the compositions described herein to at least a portion of the skin. The phospholipids in cells are replaced over time with a small percentage of metabolic turnover every day. Therefore, regular or daily application of the composition can improve the quality of deuterated P. UFAs can be absorbed into cells. Repeated use can increase the amount of deuterated P in dermal cells. The concentration of UFAs is sufficient to inhibit lipid chain autoxidation.

[0064] Periodic application preferably includes twice a day, once a day, or several times a week. Consistent application is necessary to maintain an effective amount of deuterated PUFAs. Thus, the consistent use of deuterated PUFAs in phospholipids and cellular turnover over time As phospholipids containing deuterated PUFAs are replaced, the supply of available phospholipids containing deuterated PUFAs increases. In other words, failure to enforce consistent application , resulting in either a reduction or complete loss of the beneficial results described herein.

[0065] One particular benefit resulting from the consistent application of these compositions is that they are at least partially reactive to ROS. The reduction of skin odor, which is caused by the aging and breakdown of fatty acids in cells. With age, the ability to scavenge ROS decreases, which is due to a higher rate of lipid chain self-cleavage. In the skin, the resulting auto-oxidative degradation leads to aging skin. It gives rise to a characteristic odor associated with it, which many people find very unpleasant. The method of using the compositions of the present invention stabilizes phospholipids in dermal cells from such degradation. These compositions are preferably prepared in the presence of soap. The composition may take the form of a body wash, lotion, or cream.

[0066] Pharmaceutical Composition The compositions described herein are useful for treating dry skin, treating scars, treating aging skin, and It can be used for medicinal purposes, such as for the treatment of sweat glands in the form of deodorants. The objectives include both prescription-based and over-the-counter based products.

[0067] The composition may comprise an additional agent in combination with at least one pharmaceutically acceptable excipient. Acceptable excipients are non-toxic, aid in administration, and are suitable for use in the preparation of the claimed compounds. Such excipients are generally available to those skilled in the art and do not adversely affect the therapeutic benefit of the compound. The agent may be any solid, liquid, or semi-solid suitable for use in the treatment of ulcers and ulcers. Acceptable agents include anti-pruritic, anti-scarring, and other conventional drugs used in topical compositions. Antioxidants such as benzoquinone, mitoquinone, mitoquinol, vitamin C, or vitamin E may be used in the preparation of the present invention. It can be included in the compositions described herein in any suitable amount. [Example]

[0068] The present invention will be further understood by reference to the following examples, which are provided to illustrate, but are not to be construed as limiting the scope of the invention. The present invention is intended to be purely illustrative of the invention as an illustration of a single embodiment of the invention. The scope is not limited by the illustrated embodiments, which are intended only. In addition to those described herein, various methods of the present invention are within the scope of the present invention. Modifications will become apparent to those skilled in the art from the foregoing description and accompanying drawings. Variations fall within the scope of the appended claims. In these examples, the following terms are used in conjunction with the terms used in this specification: When used in this publication, abbreviations have the following meanings: It has meaning. D2-AA = 13,13-D2-arachidonic acid AA = arachidonic acid D2-LA = 11,11-D2-linoleic acid LA = linoleic acid

[0069] Example 1 - Reduction of skin odor Mice are known to produce a skin odor, and the causative substance is 2-nonenal. The present example investigates the contribution of lipid chain autoxidation to the generation of such skin odor. To study this, two groups of BALB / c mice were tested. The first group's diet consisted of D2-LA ethyl ester. D2-LA ethyl esters were administered in amounts such that the esters constituted approximately 10% or less of the ingested PUFAs. The other groups were fed diets containing otherwise identical amounts of LA ethyl ester. After 4 weeks of dosing, urine from each group was collected over two days and then The skin samples are analyzed to assess the difference in the amount of 2-nonenal. According to the present invention, sebum exudate can be evaluated by swabbing or the like. The group whose diet was supplemented with D2-linoleic acid ethyl ester showed an increase in lipid chain auto-oxidation in dermal cells. The amount of 2-nonenal is significantly reduced due to the stabilization of PUFA against oxidation.

Claims

1. 1. A composition suitable for topical application comprising an effective amount of one or more deuterated polyunsaturated fatty acids or esters thereof, wherein the amount of deuterated polyunsaturated fatty acids is sufficient to inhibit lipid autoxidation, thereby reducing skin damage.

2. The composition of claim 1 , wherein the composition is a cosmetic composition.

3. The composition of claim 1 , wherein the composition is a skin care or pharmaceutical composition.

4. 2. The composition of claim 1, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linoleic acid or ester thereof.

5. 2. The composition of claim 1, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linoleic acid or ester thereof.

6. 2. The composition of claim 1, wherein the deuterated polyunsaturated fatty acid or ester thereof is a mixture of deuterated linoleic acid or ester thereof and deuterated linolenic acid or ester thereof.

7. The composition of claim 1 , wherein the composition is a cream, ointment, lotion, paste, emollient, spray, or emulsion.

8. 10. The composition of claim 1, wherein the polyunsaturated fatty acid or ester thereof is present in an amount of about 0.1% w / w to about 25% w / w.

9. 10. The composition of claim 1, further comprising one or more ingredients selected from the group consisting of UV absorbers, humectants, antioxidants, structuring agents, thickeners, emulsifiers, silicone agents, preservatives, and additional active pharmaceutical ingredients / active agents.

10. 1. A method for reducing skin breakdown in a patient's skin, comprising applying to the skin a cosmetic or skin care composition comprising an effective amount of one or more deuterated polyunsaturated fatty acids or esters thereof in an amount effective to inhibit lipid autooxidation and subsequent damage to the dermis of the skin.

11. 11. The method of claim 10, wherein the method attenuates the odor of aged skin.

12. The method of claim 10, wherein the composition is a cosmetic composition.

13. The method of claim 10, wherein the composition is a skin care composition.

14. 11. The method of claim 10, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linoleic acid or ester thereof.

15. 11. The method of claim 10, wherein the deuterated polyunsaturated fatty acid or ester thereof is deuterated linoleic acid or ester thereof.

16. 11. The method of claim 10, wherein the deuterated polyunsaturated fatty acid or ester thereof is a mixture of deuterated linoleic acid or ester thereof and deuterated linolenic acid or ester thereof.

17. 11. The method of claim 10, wherein the composition is a cream, ointment, lotion, paste, emollient, spray, paste, or emulsion.

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