1,4-Dihydroquinazolinone compounds and their uses

Abstract

To provide novel therapeutic agents and methods that address the long-standing need for improved treatment of HCM and related cardiac disorders. [Solution] Dihydroquinazolinone and azadihydroquinazolinone compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

Description

[Technical Field]

[0001] cross reference This application claims the benefit of U.S. Provisional Application No. 63 / 377,175, filed on 26 September 2022, which is incorporated herein by reference in its entirety. [Background technology]

[0002] Background of the Invention Hypertrophic cardiomyopathy (HCM) is a chronic, progressive disease of the cardiac sarcomere. The etiology of HCM is multifactorial; a significant proportion of affected individuals have at least one mutation in a gene encoding cardiac sarcomere proteins. Regardless of the cause of HCM, in many cases, excessive myosin-actin cross-bridge formation during systole and diastole leads to hyperkinetic contraction and relaxation disorders. Over time, this excessive stress leads to tissue remodeling, histologically characterized by myocyte hypertrophy, myofilamentous disorder, microvascular remodeling, and fibrosis. HCM can be hereditary (e.g., genetic) or non-hereditary. HCM includes hyperosmotic, monogenic, autosomal dominant cardiomyopathy. Such HCM can be caused by one or more of the more than 1,000 known point mutations in any one of the proteins contributing to the sarcomere, the functional unit of the cardiomyocyte. It is known that approximately 1 in 500 individuals in the general population have left ventricular hypertrophy that cannot be explained by other known causes (e.g., hypertension or valvular heart disease), and that many of these individuals may have HCM once other hereditary causes (e.g., lysosomal storage disorders), metabolic, or invasive causes have been ruled out.

[0003] Drug therapies for HCM are limited, and the symptoms of many patients are empirically managed with beta blockers, non-dihydropyridine calcium channel blockers, and / or disopyramide. None of these agents are labeled for the treatment of HCM, and essentially, there is no evidence from rigorous clinical trials to guide their use. In approximately 60% of patients with HCM, when the left ventricular outflow tract is obstructed, blood flow is inhibited and a pressure gradient occurs between the LV cavity and the aorta. In patients with hemodynamically significant outflow tract obstruction (gradient >50 mmHg), although clinical morbidity and mortality are significant, surgical myectomy or alcohol septal ablation can be utilized to relieve the hemodynamic obstruction. Novel therapeutic agents and methods are provided herein to address the long-standing need for improved treatment of HCM and related cardiac disorders. Summary of the Invention Means for Solving the Problems

[0004] Summary of the Invention The present disclosure provides compounds and salts thereof for use in treating a disease. In certain aspects, the present disclosure provides compounds of formula (I), (II), and (III), pharmaceutical compositions thereof, and methods of use in the treatment of a disease.

[0005] As used herein, formula (I):

Chemical formula

[0006] In this specification, formula (II): [ka] A compound represented by or a salt thereof is disclosed, in formula (II): n is 0, 1, 2, 3, or 4; Each R 1 Independently: Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Those that are replaced as needed Selected from; R 2 teeth: Halogen, -NO2, -CN, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b)C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b , and -S(O)2R 10b ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Those that are replaced as needed Selected from; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed; R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN; and Halogen, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9d It is replaced as needed; R 7 teeth: Hydrogen, as well as halogens, -OR 10e , -SR 10e , -N(R 10e )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; R 8 teeth: Hydrogen, as well as halogens, -OR 10f , -SR 10f , -N(R 10f )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; R 11 teeth: Halogen, -NO2, -CN, -OR 10g , -SR 10g, -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g , and -S(O)2R 10g ; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =S, =N(R 10g ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g Those that are replaced as needed Selected from; R 12 teeth, hydrogen; Halogen, CN, OH, OR 10h , N(R10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h C, which is optionally substituted with one or more substituents independently selected from the group consisting of 1~6 alkyl; and C 3~6 Carbon rings and 3- to 10-membered heterocycles, each consisting of a halogen, CN, OH, or OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h Substituted as necessary with one or more substituents independently selected from the group consisting of Selected from; or R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system; Each R 9a Independently: Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b)2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b’ Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9c Independently: Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c, -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9d Independently: Halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d ,-C(O)N(R 10d )2, -N(R 10d )C(O)R 10d , -N(R 10d )C(O)N(R 10d )2, -OC(O)N(R 10d )2, -N(R 10d )C(O)OR 10d , -C(O)OR 10d ,-OC(O)R 10d ,-S(O)R 10d -S(O)2R 10d -NO2, =O, =S, =N(R 10d ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d ,-C(O)N(R 10d )2, -N(R 10d )C(O)R 10d , -N(R 10d )C(O)N(R 10d )2, -OC(O)N(R 10d )2, -N(R 10d )C(O)OR 10d , -C(O)OR 10d ,-OC(O)R 10d ,-S(O)R 10d -S(O)2R10d -NO2, =O, =S, =N(R 10d ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9g Independently: Halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g), and one or more substituents selected independently of -CN as needed. Selected from; Each R 10a , R 10b , R 10c , R 10d , R 10e , R 10f , R 10g , R 10h Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 The haloalkyl group is selected from those that are optionally substituted with one or more substituents independently selected from the haloalkyl group.

[0007] This specification discloses a method for treating a cardiovascular disease or related condition, wherein the method involves administering a compound or salt of formula (III) to a subject in need: [ka] or the process of administering the salt thereof, in formula (III), X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) selected from; Each R 1 Independently: hydrogen; Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Those that are replaced as needed Selected from; R 2 teeth: C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b, -N(R 10b )2, -C(O)R 10b , -C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b , -OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -S(O)R 10b , -S(O)2R 10b , -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 is optionally substituted with one or more substituents independently selected from carbocyclic rings and 3- to 10-membered heterocyclic rings, where this C 3~10 carbocyclic ring and 3- to 10-membered heterocyclic ring are each optionally substituted with one or more R 9b ; and C 3~10 is a carbocyclic ring and 3- to 10-membered heterocyclic ring, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b , -C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b , -OC(O)R 10b , -S(O)R 10b , -S(O)2R 10b , -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 alkyl, C 2~6 alkenyl, and C 2~6 alkynyl, and is optionally substituted with one or more substituents independently selected therefrom, where C1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Those that are replaced as needed Selected from; R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, and any of these is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, and C 3~10 In each case, the C is substituted as needed with one or more substituents independently selected from the carbon ring and the 3-membered to 10-membered heterocycle. 3~10Each of the carbon ring and the 3- to 10-membered heterocyclic ring is optionally substituted with one or more substituents independently selected from halogen, -OR 10c 、-SR 10c 、-N(R 10c )2、-NO2、and -CN; and C 3~10 A carbon ring and a 3- to 10-membered heterocyclic ring, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR 10c 、-SR 10c 、-N(R 10c )2、-NO2、and -CN selected from; or R 5 together with R 6 forms a 3- to 10-membered heterocyclic ring or a C 3~10 carbon ring, where the 3- to 10-membered heterocyclic ring or C 3~10 carbon ring is optionally substituted with one or more R 9c ; R 7 is: Hydrogen, and C 10d alkyl optionally substituted with one or more substituents independently selected from halogen, -OR 10d 、-SR 10d )2、-NO2、and -CN 1~6 selected from; R is: 8 Hydrogen; and C alkyl optionally substituted with one or more substituents independently selected from halogen, -OR 10e 、-SR 10e 、-N(R 10e )2、-NO2、-CN、C 3~10 carbon ring, and a 3- to 10-membered heterocyclic ring, where each C 1~6 carbon ring and 3- to 10-membered heterocyclic ring are halogen, -OR 3~10 、-SR 10e 、-N(R 10e 、-N(R 10e) Substituted as needed with one or more substituents independently selected from -NO2 and -CN Selected from; Each R 9a Independently: Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9c Independently: Halogen, -OR 10c, -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 10a , R 10b , R 10c , R 10d , R 10e Independently: Hydrogen; and C 1~6Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from. References

[0008] All publications, patents, and patent applications referenced herein are incorporated herein by reference to the same extent as each individual publication, patent, or patent application is specifically incorporated by reference. [Modes for carrying out the invention]

[0009] Detailed description of the invention In a particular context, the present disclosure provides a method for treating a heart disease in an individual in need, comprising administering a therapeutically effective dose of a compound of formula (I), (II), or (III).

[0010] Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rhematic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

[0011] Cardiomyopathy is a heart disease in which the heart may become abnormally enlarged, thickened, and / or stiffened, and which may have few or no symptoms in its early stages. As the disease progresses, symptoms may include, but are not limited to, shortness of breath, fatigue, arrhythmias, syncope, and the development of heart failure. Types of cardiomyopathy include, but are not limited to, arrhythmic right ventricular dysplasia, dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and takotsubo cardiomyopathy. Hypertrophic cardiomyopathy (HCM) can be hereditary (e.g., genetic) or non-hereditary. HCM can be obstructive or non-obstructive. Hereditary hypertrophic cardiomyopathy (HCM) includes a group of hyperosmotic, monogenic, autosomal dominant cardiomyopathy disorders. HCM can be caused by one or more of the more than 1,000 known point mutations in any one of the proteins that contribute to sarcomeres, the functional units of the cardiomyocyte.

[0012] In approximately two-thirds of individuals with HCM, the left ventricular outflow tract (LVOT), the pathway through which blood flows out of the heart, is obstructed by hypertrophied and diseased muscle, restricting blood flow from the heart to other parts of the body (obstructive HCM). In other individuals, the thickened myocardium does not obstruct the LVOT, and the disease is driven by diastolic dysfunction resulting from hypertrophied and hardened myocardium (non-obstructive HCM). In both obstructive and non-obstructive HCM individuals, exertion can lead to fatigue or shortness of breath, impairing their ability to participate in daily activities. HCM is also associated with an increased risk of atrial fibrillation, stroke, heart failure, and sudden cardiac death.

[0013] While currently available treatments for HCM are varied in their effectiveness in alleviating symptoms, they typically show decreased efficacy as the duration of the disease increases. Therefore, patients are empirically managed with beta-blockers, non-dihydropyridine calcium channel blockers, and / or disopyramides. In approximately 60% of patients with HCM, left ventricular outflow tract obstruction impairs blood flow and creates a pressure gradient between the LV lumen and the aorta. Surgical myocardial resection or alcohol septal ablation may be used to alleviate hemodynamic obstruction in patients with hemodynamically significant outflow tract obstruction (gradient > 50 mmHg), although clinical morbidity and mortality are significant. Novel therapeutic agents and methods addressing the long-standing need for improved treatment of HCM and related cardiac disorders are provided herein.

[0014] The compounds of the present invention, or their pharmaceutically acceptable salts, may modify the natural history of HCM and other diseases, rather than merely temporarily alleviating symptoms. The mechanisms by which they provide clinical benefit to HCM patients may be extended to patients with other forms of heart disease that share similar pathophysiology, with or without demonstrable genetic influences. For example, effective treatment of HCM by improving ventricular relaxation during diastole may also be effective in a broader population characterized by diastolic dysfunction. The compounds of the present invention, or their pharmaceutically acceptable salts, may specifically target the underlying causes of these conditions or act on other downstream pathways. Thus, the compounds of the present invention, or their pharmaceutically acceptable salts, may also benefit patients with diastolic heart failure with preserved ejection fraction, ischemic heart disease, angina pectoris, or restrictive cardiomyopathy. The compounds of the present invention or their pharmaceutically acceptable salts may also promote healthy ventricular remodeling of left ventricular hypertrophy resulting from volumetric or pressure overload (e.g., chronic mitral regurgitation, chronic aortic stenosis, or chronic systemic hypertension) in conjunction with treatments aimed at correcting or mitigating the primary cause of volumetric or pressure overload (valve repair / replacement, effective antihypertensive treatment). By reducing left ventricular filling pressure, the compounds may reduce the risk of pulmonary edema and respiratory failure. Reducing or eliminating functional mitral regurgitation and / or lowering left atrial pressure may reduce the risk of paroxysmal or permanent atrial fibrillation, and consequently reduce the associated risk of arterial thromboembolic complications, including but not limited to cerebral artery embolic stroke. Reducing or eliminating either dynamic and / or static left ventricular outflow tract obstruction may reduce the likelihood of needing either surgical or percutaneous septal reduction therapy, which carries its associated risk of short-term and long-term complications. The compound or its pharmaceutically acceptable salts may reduce the severity of chronic ischemic conditions associated with HCM, thereby reducing the risk of sudden cardiac death (SCD) or its equivalent (frequent and / or recurrent ICD discharge) and / or the need for potentially toxic antiarrhythmic drugs in patients with implantable cardioverter-defibrillators.Compounds or their pharmaceutically acceptable salts may be useful in reducing or eliminating the need for concomitant medications with their associated potential toxicity, drug interactions, and / or side effects. Compounds or their pharmaceutically acceptable salts may reduce and / or slow the progression of interstitial cardiomyopathy, and may halt or reverse left ventricular hypertrophy. definition

[0015] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art to which this invention pertains.

[0016] As used herein and in the claims, the singular forms “a,” “an,” and “the” mean plural unless otherwise indicated by the context. Includes references.

[0017] The term “C x~y " or "C x ~C y The term "C" (for example, when used with a chemical part such as alkyl, alkenyl, or alkynyl) means that the chemical part contains a group of several carbon atoms, with x or more carbon atoms ~ y or fewer carbon atoms, but subject to the following conditions: x~y " or "C x ~C y The term "C" does not mean that if that chemical part is replaced by a second chemical part, it limits the number of carbon atoms that can bond to that chemical part. For example, the term "C" 1~6 "Alkyl" or "C1-C6 alkyl" refers to substituted or unsubstituted saturated hydrocarbon groups including linear alkyl groups (e.g., linear alkyl groups) and branched alkyl groups containing one, two, three, four, five, or six carbon atoms. 1~6 Any substituent on an alkyl group can have multiple carbon atoms. For example, C 1~6 If the alkyl group is optionally substituted with a second chemical moiety containing two carbon atoms, then C1~6 It should be understood that alkyl groups can contain between 1 and 8 carbon atoms.

[0018] The term “C x~y "Alkenil" and "C x~y "Alkynyl" refers to a substituted or unsubstituted unsaturated aliphatic group that is similar in length and possible substitutions to the aforementioned alkyl groups, but each contains at least one double or triple bond.

[0019] "Amino" refers to the -NH2 portion.

[0020] "Cyano" refers to the -CN portion.

[0021] "Nitro" refers to the -NO2 portion.

[0022] "Oxa" refers to the -O- part.

[0023] "Oxo" refers to the O part.

[0024] "Thioxo" refers to the S portion.

[0025] "Imino" refers to the =NH part.

[0026] "Oxymo" refers to the =N-OH portion.

[0027] "Hydrazino" refers to the =N-NH2 portion.

[0028] "Alkyl" refers to a linear (e.g., linear) or branched hydrocarbon moiety consisting only of carbon and hydrogen atoms that are completely saturated. In certain embodiments, "alkyl" contains 1 to 15 carbon atoms (e.g., C1 to C15). 15 Alkyl). In certain embodiments, alkyl contains 1 to 13 carbon atoms (e.g., C1 to C13). 13Alkyl). In certain embodiments, the alkyl contains 1 to 8 carbon atoms (e.g., C1-C8 alkyl). In certain embodiments, the alkyl contains 1 to 6 carbon atoms (e.g., C1-C6 alkyl). In other embodiments, the alkyl contains 1 to 5 carbon atoms (e.g., C1-C5 alkyl). In other embodiments, the alkyl contains 1 to 4 carbon atoms (e.g., C1-C4 alkyl). In other embodiments, the alkyl contains 1 to 3 carbon atoms (e.g., C1-C3 alkyl). In other embodiments, the alkyl contains 1 to 2 carbon atoms (e.g., C1-C2 alkyl). In other embodiments, the alkyl contains 1 carbon atom (e.g., C1 alkyl, e.g., methyl). In other embodiments, the alkyl contains 5 to 15 carbon atoms (e.g., C5-C 15 Alkyl). In other embodiments, the alkyl group contains 5 to 8 carbon atoms (e.g., C5-C8 alkyl). In other embodiments, the alkyl group contains 2 to 5 carbon atoms (e.g., C2-C5 alkyl). In other embodiments, the alkyl group contains 3 to 5 carbon atoms (e.g., C3-C5 alkyl). In other embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl (n-propyl), 1-methylethyl (2-propyl, iso-propyl), 1-butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), and 1-pentyl (n-pentyl). The alkyl group is bonded to the rest of the molecule by a single bond.

[0029] "Aminoalkyl" refers to a portion bonded via a nitrogen atom in the form of -N(H)(alkyl) or N(alkyl)(alkyl). When the portion is N(alkyl)(alkyl), the two alkyl groups bonded to the nitrogen may be the same alkyl group or different alkyl groups.

[0030] "Alkoxy" refers to the part of the formula -O-alkyl (alkyl is an alkyl chain as defined earlier) that is bonded via an oxygen atom.

[0031] An "alkenyl" refers to a linear (e.g., linear) or branched hydrocarbon portion consisting only of carbon and hydrogen atoms, wherein the portion contains at least one carbon-carbon double bond. In certain embodiments, an alkenyl contains 2 to 12 carbon atoms. In certain embodiments, an alkenyl contains 2 to 8 carbon atoms. In other embodiments, an alkenyl contains 2 to 4 carbon atoms. Alkenyls are bonded to the rest of the molecule by single bonds, such as ethenyl (i.e., vinyl), propa-1-enyl (i.e., allyl), buta-1-enyl, penta-1-enyl, penta-1,4-dienyl, etc.

[0032] "Alkynyl" refers to a linear (e.g., linear) or branched hydrocarbon portion consisting only of carbon and hydrogen atoms, wherein the portion contains at least one carbon-carbon triple bond. In some embodiments, the alkynyl contains 2 to 12 carbon atoms. In some embodiments, the alkynyl optionally further contains at least one carbon-carbon double bond. In certain embodiments, the alkynyl contains 2 to 8 carbon atoms. In other embodiments, the alkynyl contains 2 to 6 carbon atoms. In other embodiments, the alkynyl contains 2 to 4 carbon atoms. The alkynyl is bonded to the rest of the molecule by single bonds, such as ethynyl, propynyl, butynyl, pentynyl, hexynyl, etc.

[0033] An "alkylene" or "alkylene chain" refers to a linear (e.g., straight) or branched divalent hydrocarbon portion. An "alkylene" or "alkylene chain" can link a portion of a molecule to a second portion. An "alkylene" or "alkylene chain" consists only of carbon and hydrogen atoms (substitution of alkylene with one or more substituents containing non-hydrogen atoms such as N, O, and S may be specified). An "alkylene" or "alkylene chain" does not have to contain unsaturation (even if it is an alkylene bond to the rest of the molecule). In certain embodiments, an "alkylene" or "alkylene chain" contains 1 to 12 carbon atoms, such as methylene, ethylene, propylene, n-butylene, etc. An alkylene chain can be bonded to a portion of a molecule via one single bond and to a second portion via one single bond. The bonding points of the alkylene chain to the rest of the molecule and the second part can be via one carbon atom in the alkylene chain or via any two carbon atoms in the alkylene. In certain embodiments, the alkylene contains 1 to 8 carbon atoms (e.g., C1-C8 alkylene). In other embodiments, the alkylene contains 1 to 5 carbon atoms (e.g., C1-C5 alkylene). In other embodiments, the alkylene contains 1 to 4 carbon atoms (e.g., C1-C4 alkylene). In other embodiments, the alkylene contains 1 to 3 carbon atoms (e.g., C1-C3 alkylene). In other embodiments, the alkylene contains 1 to 2 carbon atoms (e.g., C1-C2 alkylene). In other embodiments, the alkylene contains 1 carbon atom (e.g., C1 alkylene). In other embodiments, the alkylene contains 5 to 8 carbon atoms (e.g., C5-C8 alkylene). In other embodiments, the alkylene contains 2 to 5 carbon atoms (e.g., C2-C5 alkylene). In other embodiments, the alkylene contains 3 to 5 carbon atoms (e.g., C3-C5 alkylene).

[0034] An "alkenylene" or "alkenylene chain" refers to a linear (e.g., straight) or branched divalent hydrocarbon portion. An "alkenylene" or "alkenylene chain" can link a portion of a molecule to a second portion. An "alkenylene" or "alkenylene chain" consists only of carbon and hydrogen atoms (substitutions of alkenylene with one or more substituents containing non-hydrogen atoms such as N, O, and S may be specified). An "alkenylene" or "alkenylene chain" contains at least one carbon-carbon double bond. In certain embodiments, an "alkenylene" or "alkenylene chain" contains 2 to 12 carbon atoms. An alkenylene chain can be bonded to a portion of a molecule via one single bond and to a second portion via one single bond. The bonding points of the alkenylene chain to the rest of the molecule and the second portion can be via one carbon in the alkenylene chain or via any two carbons in the alkenylene chain. In certain embodiments, the alkenylene contains 2 to 8 carbon atoms (e.g., C2-C8 alkenylene). In other embodiments, the alkenylene contains 2 to 5 carbon atoms (e.g., C2-C5 alkenylene). In other embodiments, the alkenylene contains 2 to 4 carbon atoms (e.g., C2-C4 alkenylene). In other embodiments, the alkenylene contains 2 to 3 carbon atoms (e.g., C2-C3 alkenylene). In other embodiments, the alkenylene contains 5 to 8 carbon atoms (e.g., C5-C8 alkenylene). In other embodiments, the alkenylene contains 2 to 5 carbon atoms (e.g., C2-C5 alkenylene). In other embodiments, the alkenylene contains 3 to 5 carbon atoms (e.g., C3-C5 alkenylene).

[0035] An "alkynylene" or "alkynylene chain" refers to a linear (e.g., straight) or branched divalent hydrocarbon portion. An "alkynylene" or "alkynylene chain" can link a portion of a molecule to a second portion. An "alkynylene" or "alkynylene chain" consists only of carbon and hydrogen (substitutions of alkynylene with one or more substituents containing non-hydrogen atoms such as N, O, and S may be specified). An "alkynylene" or "alkynylene chain" contains at least one carbon-carbon triple bond. In certain embodiments, an "alkynylene" or "alkynylene chain" contains 2 to 12 carbon atoms. An alkynylene chain can be bonded to a portion of a molecule via one single bond and to a second portion via one single bond. The bonding points of the alkynylene chain to the rest of the molecule and the second portion can be via one carbon in the alkynylene chain or via any two carbons in the alkynylene chain. In certain embodiments, the alkylylene contains 2 to 8 carbon atoms (e.g., C2-C8 alkylylene). In other embodiments, the alkylylene contains 2 to 5 carbon atoms (e.g., C2-C5 alkylylene). In other embodiments, the alkylylene contains 2 to 4 carbon atoms (e.g., C2-C4 alkylylene). In other embodiments, the alkylylene contains 2 to 3 carbon atoms (e.g., C2-C3 alkylylene). In other embodiments, the alkylylene contains 2 carbon atoms (e.g., C2 alkylene). In other embodiments, the alkylylene contains 5 to 8 carbon atoms (e.g., C5-C8 alkylene). In other embodiments, the alkylylene contains 3 to 5 carbon atoms (e.g., C3-C5 alkylene).

[0036] As used herein, the term "carbocyclic ring" refers to a saturated or unsaturated (e.g., aromatic or unaromatically unsaturated) ring or ring system in which each atom of the ring is carbon. For example, the term "carbocyclic ring" includes monocyclic rings of 3 to 12 members (e.g., monocyclic rings of 3 to 10 members) and polycyclic ring systems of 4 to 20 members (e.g., spiropolycyclic ring systems of 5 to 15 members, bridging polycyclic ring systems of 5 to 15 members, or condensed polycyclic ring systems of 4 to 15 members). For example, a carbocyclic ring is a bicyclic ring of 4 to 15 members (e.g., spirodicyclic rings of 5 to 15 members, bridging bicyclic ring systems of 5 to 15 members, or condensed bicyclic ring systems of 4 to 15 members). For example, a carbocyclic ring is a tricyclic ring system that may be bridging, condensed, spiro, or a combination thereof. For example, a carbocyclic ring is a tetracyclic ring system that may be bridging, condensed, spiro, or a combination thereof. For example, examples of carbocyclic rings include condensed and bridged ring systems, condensed and spiro ring systems, bridged and spiro ring systems, and condensed and bridged ring systems that are also spiro rings. Each ring in a polycyclic carbocyclic ring can be selected from saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings. In exemplary embodiments, the aromatic ring of the polycyclic carbocyclic ring, e.g., phenyl, can be condensed to a saturated or unsaturated ring (e.g., cyclohexane, cyclopentane, cyclohexene, or phenyl). Any combination of saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings is acceptable for the polycyclic carbocyclic ring, as long as the bond valency allows. For example, the polycyclic carbocyclic ring may be a spiro-bicyclic ring, e.g., spiropentane. For example, polycyclic carbocyclic rings include any combination of ring sizes such as 2-2 spiro ring systems (e.g., spiro[2.2]pentane), 3-3 spiro ring systems, 4-4 spiro ring systems, 4-5 fused ring systems (e.g., bicyclo[4.5.0] fused ring systems), 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems (e.g., naphthalene), 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems.Examples of carbocyclic compounds include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, naphthyl, trans-bicyclo[4.4.0]decane, cis-bicyclo[4.4.0]decane, spiro[3.4]octane, fluorantene, and bicyclo[1.1.1]pentanyl.

[0037] The term "aryl" refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ring system containing a delocalized (4n+2)π-electron system of at least one ring that follows Hückel's rule, where n is an integer equal to or greater than 0. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system contains only hydrogen and carbon atoms. In some embodiments, the aromatic monocyclic or polycyclic system contains 3 to 20 carbon atoms. In some embodiments, at least one of the rings in the polycyclic aromatic ring system is aromatic. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system contains a delocalized (4n+2)π-electron system of a ring that follows Hückel's rule. In some embodiments, ring systems from which an aryl group is derived include, but are not limited to, groups such as benzene, fluorene, indan, indene, anthracene, tetralin, and naphthalene. In some embodiments, the aryl substituent is uncharged (e.g., neutral). In some embodiments, the aryl substituent is neutral. In some embodiments, the aryl substituent is zwitterionic, and, as an alternative or additional, in some embodiments, the aryl substituent is uncharged. In some embodiments, the aryl substituent does not carry a charge. In some embodiments, the aryl substituent does not carry a net charge. In some embodiments, the aryl substituent is neither net charge-carrying nor zwitterionic. In some embodiments, none of the carbon atoms in the aryl substituent are charged. In some embodiments, none of the carbon atoms in the aryl substituent are charged. Alternatively, in some embodiments, the aryl substituent is positively or negatively charged, or zwitterionic.

[0038] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon. Examples of cycloalkyls include monocyclic and polycyclic rings such as 3-10 membered monocyclic rings, 5-12 membered bicyclic rings, 5-12 membered spirodicyclic rings, and 5-12 membered bridging rings. In certain embodiments, the cycloalkyl contains 3-10 carbon atoms. In other embodiments, the cycloalkyl contains 3-7 carbon atoms. In other embodiments, the cycloalkyl contains 5-7 carbon atoms. The cycloalkyl may be bonded to the rest of the molecule by single bonds. Examples of monocyclic cycloalkyls include, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyl compounds, though not limited to these, include adamantyl, spiropentane, norbornyl (i.e., bicyclo[2.2.1]heptanyl), dekalinyl, 7,7-dimethylbicyclo[2.2.1]heptanyl, bicyclo[1.1.1]pentanyl, and spiropentane.

[0039] The term "cycloalkenyl" refers to a saturated ring in which each atom of the ring is carbon, and there is at least one double bond between any two ring carbon atoms. Examples of cycloalkenyls include monocyclic and polycyclic rings, such as 3-10 membered monocyclic rings and 4-12 membered bicyclic rings (e.g., 5-12 membered bridging bicyclic rings, 4-12 membered fused bicyclic rings, and 5-12 membered spiro-dicyclic rings). In other embodiments, cycloalkenyls contain 5-7 carbon atoms. Cycloalkenyls may be bonded to the rest of the molecule by single bonds. Examples of monocyclic cycloalkenyls include, for example, cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0040] The term "halo," or "halogen" or "halide," means fluoro, chloro, bromo, or iodine. In some embodiments, the halo is fluoro, chloro, or bromo. In some embodiments, the halo is fluoro or chloro.

[0041] The term "haloalkyl" refers to an alkyl group as previously defined, substituted with one or more halogens, such as trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl, 1-chloromethyl-2-fluoroethyl, etc. In some embodiments, the alkyl portion of the haloalkyl group is further substituted as necessary, as described herein.

[0042] The term “heterocycle,” as used herein, refers to a saturated or unsaturated (e.g., aromatic or non-aromatic unsaturated) ring or ring system in which one or more heteroatoms are members of the ring or ring system. Examples of heteroatoms include N, O, Si, P, B, and S atoms. Examples of heterocycles include 3- to 12-membered monocyclic rings (e.g., 3- to 10-membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 4- to 15-membered fused polycyclic ring systems, 5- to 15-membered spiropolycyclic ring systems, and 5- to 15-membered bridging polycyclic ring systems). Examples of heterocycles include 4- to 20-membered bicyclic ring systems (e.g., 4- to 15-membered fused bicyclic ring systems, 5- to 15-membered spirodicyclic ring systems, and 5- to 15-membered bridging bicyclic ring systems). Examples of heterocycles include tricyclic ring systems that may be bridging, fused, spiro, or combinations thereof. For example, heterocycles include tetracyclic ring systems that can be bridged, condensed, spiro, or a combination thereof. For example, heterocycles include condensed and bridged ring systems, condensed and spiro ring systems, bridged and spiro ring systems, and condensed and bridged ring systems that are also spiro. Each ring in a polycyclic heterocycle can be selected from saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings. Polycyclic heterocycles include any combination of saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings, as long as the bond valency allows. In exemplary embodiments, an aromatic ring, such as pyridyl or phenyl, can be condensed in the heterocycle to a saturated or unsaturated ring, such as cyclohexane, cyclopentane, morpholine, piperidine, or cyclohexene, as long as at least one atom in the resulting condensed ring system is a heteroatom. Examples of polycyclic heterocycles include any combination of ring sizes such as 3-3 spiro, 4-5 fused ring systems, 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems, 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. Examples of bicyclic heterocycles include spiro dicyclic rings, such as 5- to 12-membered spiro dicyclic rings, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, the heterocycle contains multiple heteroatoms. In some embodiments, the heterocycle contains nitrogen, oxygen,The heterocycle includes atoms selected from nitrogen and sulfur. In some embodiments, the heterocycle includes multiple atoms selected from nitrogen, oxygen, and sulfur. Non-limiting examples of heterocycles include pyridine, pyrrole, indole, carbazole, piperidine, oxazole, morpholine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran. Non-limiting examples of heterocycles include azepinyl, acridinyl, benzimidazolyl, benzoindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxynyl, benzopyranyl, benzopyran Nyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyrimidinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6, 7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazoli Lu, indyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolidinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthilidinyl, 1,6-naphthilidinolyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxyranil, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenadinyl,Phenothiazinyl, phenoxadinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridadinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo Examples include [4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyrimidinyl, and thiophenyl (i.e., thienyl). In some embodiments, the heterocycle is bonded to the molecule by a carbon atom. In some embodiments, the heterocycle is bonded to the molecule by a nitrogen atom. In some embodiments, the heterocycle comprises a portion selected from heteroaryl, heterocycloalkyl, and heterocycloalkenyl. In some embodiments, the heterocycle is heteroaryl. In some embodiments, the heterocycle is heterocycloalkyl. In some embodiments, the heterocycle is a heterocycloalkenyl.

[0043] In some embodiments, the heterocycle includes atoms selected from nitrogen and oxygen. In some embodiments, the heterocycle includes atoms selected from nitrogen and sulfur. In some embodiments, the heterocycle includes atoms selected from oxygen and sulfur. In some embodiments, the heterocycle includes atoms selected from nitrogen. In some embodiments, the heterocycle includes atoms selected from oxygen. In some embodiments, the heterocycle includes atoms selected from sulfur.

[0044] In some embodiments, the heterocycle contains 1 to 8 heteroatoms. In some embodiments, the heterocycle contains 1 to 5 heteroatoms. In some embodiments, the heterocycle contains 1 to 3 heteroatoms. In some embodiments, the heterocycle contains 1 to 2 heteroatoms. In some embodiments, the heterocycle is monosubstituted, disubstituted, trisubstituted, tetrasubstituted, or pentasubstituted.

[0045] In a molecule (for example, in a heterocycle), one or more nitrogen atoms, if present, may be quaternized as needed. In some embodiments, the heterocyclic substituent is positively charged. In some embodiments, the heterocyclic substituent is negatively charged. In some embodiments, the heterocyclic substituent is neutral. In some embodiments, the heterocyclic substituent is zwitterionic, and, as an alternative or additional, in some embodiments, the heterocyclic substituent is uncharged. In some embodiments, the heterocyclic substituent is charge-free. In some embodiments, the heterocyclic substituent is net charge-free. In some embodiments, none of the atoms in the heterocyclic substituent are net charge-free. In some embodiments, the heterocyclic substituent is neither net charge-free nor zwitterionic.

[0046] The term “heteroaryl” refers to a portion derived from an aromatic monocyclic or aromatic polycyclic cyclic system in which one or more heteroatoms are members of the cyclic system, and the cyclic system comprises a delocalized cyclic (4n+2)π-electron system of at least one cyclic structure that obeys Hückel’s rule, where n is an integer equal to or greater than 0. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. In some embodiments, the heteroaryl comprises one or more heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the heteroaryl comprises multiple heteroatoms selected from nitrogen, oxygen, and sulfur. In certain embodiments, the “heteroaryl” comprises rings and cyclic systems comprising 3 to 20 atoms. In some embodiments, the “heteroaryl” comprises rings and cyclic systems comprising 2 to 17 carbon atoms, as well as 1 to 6 heteroatoms selected from nitrogen, oxygen, and sulfur. As used herein, a heteroaryl moiety is a monocyclic or polycyclic (e.g., bicyclic, tricyclic, or tetracyclic) ring system in which at least one of the rings is aromatic, i.e., contains a delocalized (4n+2)π electron system of the ring system that obeys Hückel's rule. Examples of heteroaryls include fused ring systems, bridging ring systems, and spiro ring systems. The heteroatom(s) of the heteroaryl moiety are oxidized as necessary. One or more nitrogen atoms, if present, are quaternized as necessary. The heteroaryl is bonded to the rest of the molecule via any atom of the ring. Examples of heteroaryls, though not limited to these, include azepinyl, acridinyl, benzimidazolyl, benzoindolyl, 1,3-benzodioxolyl, benzofuranil, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanil, benzonaphthofuranil, benzoxazolyl, benzodioxolyl, benzodioxynil, benzopyranil, benzopyranonil, benzofuranil, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinil, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridadinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloo Kuta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indazolyl, indazolyl, isoindolyl, indolinyl, isoindolyl, isoquinolyl, indolidinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthilidinyl, 1,6-naphthilidinolyl, oxadiazolyl, 2-oxoazepi Nyl, oxazolyl, oxyranil, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxadinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridadinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, i Soquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,Examples include [3-c]pyridinyl and thiophenyl (i.e., thienyl). In some embodiments, the heteroaryl substituent is positively or negatively charged. In some embodiments, the heteroaryl substituent is neutral. In some embodiments, the heteroaryl substituent is zwitterionic, and, as an alternative or addition, in some embodiments, the heteroaryl substituent is uncharged. In some embodiments, the heteroaryl substituent is charge-free. In some embodiments, the heteroaryl substituent is net charge-free. In some embodiments, the heteroaryl substituent is neither net charge-free nor zwitterionic.

[0047] The term "heterocyclic ring" includes "heteroaryl" and "heterocycloalkyl." The term "carbocyclic ring" includes "aryl" and "cycloalkyl."

[0048] The term "heterocycloalkyl" refers to a saturated ring having a carbon atom and at least one heteroatom. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkyls can be monocyclic and polycyclic rings such as 3-10 membered monocyclic rings, 6-12 membered bicyclic rings, 5-12 membered spirodicyclic rings, or 5-12 membered bridging rings. The heteroatoms of heterocycloalkyls are oxidized as needed. One or more nitrogen atoms, if present, are quaternized as needed. Heterocycloalkyls can bond to the rest of the molecule via any atom of the heterocycloalkyl, e.g., any carbon or nitrogen atom of the heterocycloalkyl, if the bonding valency allows. Examples of heterocycloalkyl groups, though not limited to them, include dioxolanil, thienyl[1,3]dithianil, decahydroisoquinolyl, imidazolinil, imidazolidinil, isothiazolidinil, isooxazolidinil, morpholinil, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinil, 2-oxopiperidinil, 2-oxopyrrolidinil, oxazolidinil, piperidinil, piperazinil, 4-piperidonil, pyrrolidinil, pyrazolidinil, quinuclidinil, thiazolidinil, tetrahydrofuryl, trithianil, tetrahydropyranil, thiomorpholinil, thiamorpholinil, 1-oxo-thiomorpholinil, 2-oxa-6-azaspiro[3.3]heptane, and 1,1-dioxo-thiomorpholinil. In some embodiments, the heterocycloalkyl contains one heteroatom. In some embodiments, the heterocycloalkyl contains one heteroatom selected from N, O, and S. In some embodiments, the heterocycloalkyl contains multiple heteroatoms. In some embodiments, the heterocycloalkyl contains multiple heteroatoms selected from N, O, and S.

[0049] The term "heterocycloalkenyl" refers to an unsaturated ring having carbon atoms and at least one heteroatom, with at least one double bond between the carbon atoms of the two rings. Heterocycloalkenyls do not include heteroaryl rings. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkenyls can be monocyclic and polycyclic rings such as 3-10 membered monocyclic rings, 6-12 membered bicyclic rings, and 5-12 membered bridging rings. In other embodiments, heterocycloalkenyls contain 5-7 ring atoms. Heterocycloalkenyls may be bonded to the rest of the molecule by single bonds. Examples of monocyclic cycloalkenyls include, for example, pyrroline (dihydropyrrole), pyrazoline (dihydropyrazole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole), dihydrofuran, dihydrothiophene, oxazoline (dihydroxazole), isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), isothiazolin (dihydroisothiazole), oxadiazoline (dihydroxadiazole), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, thiopyran, dihydrothiopyran, dioxin, dihydrodioxin, oxazine, dihydrooxazine, thiaazine, and dihydrothiazine.

[0050] The term “substituted” refers to a moiety of a compound having a substituent that replaces a hydrogen atom on one or more carbon atoms or a substituteable heteroatom (e.g., NH or NH2). It is understood that “substituted” or “substituted with” implies that such substitution follows the acceptable bond valency of the substituted atom and its substituent, and further implies that the substitution results in a stable compound (e.g., a compound that does not undergo abrupt rearrangement, cyclization, elimination, etc.). In particular embodiments, “substituted” refers to a moiety having a substituent that replaces two hydrogen atoms on the same carbon atom (e.g., two hydrogen atoms on a single carbon atom replaced by an oxo, imino, oxime, hydrazone, or thioxo group). As used herein, the term “substituted” is intended to include all acceptable substituents of an organic compound. In a broad sense, acceptable substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and non-aromatic substituents of an organic compound. The acceptable substituents may be one or more for a given organic compound, and may be the same or different.

[0051] In some embodiments, the substituents may include, for example, any of the following substituents described herein: halogen, hydroxyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=NH), oxime (=NO) (=NO H), hydrazino (=N-NH2), -R b -OR a , -R b -OC(O)-R a , -R b -OC(O)-OR a , -R b -OC(O)-N(R a )2, -R b -N(R a )2, -R b -C(O)R a , -R b -C(O)OR a , -R b -C(O)N(R a)2, -R b -OR c -C(O)N(R a )2, -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t Ure a (where t is 1 or 2), and -R b -S(O) t N(R a )2 (where t is 1 or 2); as well as alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralquinyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, any of which is alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=NH), oxime (=N-OH), hydrazine (=N-NH2), -R b -OR a , -R b -OC(O)-R a , -R b -OC(O)-OR a , -R b -OC(O)-N(R a )2, -R b -N(R a )2, -R b -C(O)R a , -R b -C(O)OR a , -R b -C(O)N(R a )2, -R b -ORc -C(O)N(R a )2, -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t Ure a (where t is 1 or 2) and -R b -S(O) t N(R a )2 (where t is 1 or 2) can be substituted as needed; where each R a R is independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, where each R a If the bond value is acceptable, alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=NH), oxime (=N-OH), hydrazine (=N-NH2), -R b -OR a , -R b -OC(O)-R a , -R b -OC(O)-OR a , -R b -OC(O)-N(R a )2, -R b -N(R a )2, -R b -C(O)R a , -R b -C(O)OR a , -R b -C(O)N(R a )2, -Rb -OR c -C(O)N(R a )2, -R b -N(R a )C(O)OR a , -R b -N(R a )C(O)R a , -R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t Ure a (where t is 1 or 2) and -R b -S(O) t N(R a )2 (where t is 1 or 2) can be substituted as needed; and here each R b These are independently selected from directly bonded, linear, or branched alkylene, alkenylene, or alkynylene chains, and each R c These are linear or branched alkylene, alkenylene, or alkynylene chains.

[0052] A double bond with an oxygen atom, such as an oxo group, is represented herein as both "=O" and "(O)". A double bond with a nitrogen atom is represented as both "=NR" and "(NR)". A double bond with a sulfur atom is represented as both "=S" and "(S)".

[0053] The phrases “parenteral administration” and “administered parenterally,” as used herein, mean, but are not limited to, administration other than enteral administration and local administration, usually by injection, including intravenous, intramuscular, intra-arterial, intrathecal, intra-articular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subepidermal, intra-articular, subcapsular, subarachnoid, intraspinal, and intrasternal injections and infusions.

[0054] The phrase “pharmaceutically acceptable” is used herein to mean a compound, material, composition, and / or dosage form that is suitable for use in contact with human and animal tissues without excessive toxicity, irritation, allergic reactions, or other problems or complications, and that is commensurate with a reasonable profit-benefit ratio, within the bounds of appropriate medical judgment.

[0055] The phrase “pharmaceutically acceptable additive” or “pharmaceutically acceptable carrier,” as used herein, means a pharmaceutically acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense that it is compatible with the other components of the formulation and is not harmful to the patient. Some examples of materials that can act as pharmaceutically acceptable carriers include: (1) sugars, e.g., lactose, glucose and sucrose; (2) starches, e.g., corn starch and potato starch; (3) cellulose and its derivatives, e.g., sodium carboxymethylcellulose, ethylcellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, e.g., cocoa butter and suppository wax; (9) oils, e.g., peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil. Examples include (10) soybean oil, (11) glycols, such as propylene glycol, (12) polyols, such as glycerin, sorbitol, mannitol, and polyethylene glycol, (13) esters, such as ethyl oleate and ethyl laurate, (14) agar, (15) buffers, such as magnesium hydroxide and aluminum hydroxide, (16) alginic acid, (17) water free of pyrogens, (18) isotonic saline, (19) Ringer's solution, (16) ethyl alcohol, (17) phosphate buffer, and (18) other non-toxic suitable substances used in pharmaceutical formulations.

[0056] The term "salt" or "pharmaceutically acceptable salt" refers to salts derived from various organic and inorganic counterions known in the art. Pharmaceutically acceptable acid addition salts can be formed using inorganic and / or organic acids. Examples of inorganic acids that can derive salts include hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, and phosphoric acid. Examples of organic acids that can derive salts include acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, and salicylic acid. Pharmaceutically acceptable base addition salts can be formed using inorganic and / or organic bases. Examples of inorganic bases that can derive salts include sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, and aluminum. Examples of organic bases that can induce salt formation include primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, and basic ion exchange resins, specifically isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, pharmaceutically acceptable base addition salts are selected from ammonium, potassium, sodium, calcium, and magnesium salts.

[0057] As used herein, “treatment” or “to treat” refers to a method for obtaining beneficial or desired outcomes with respect to a disease, disorder, or medical condition, including, but not limited to, therapeutic and / or preventive benefits. Therapeutic benefits may include, for example, the eradication or alleviation of the underlying disease being treated. Therapeutic benefits may also include, for example, the eradication or alleviation of one or more physiological symptoms associated with the underlying disease, such that improvement is observed in the subject even though the subject may still have the underlying disease. In certain embodiments, with respect to preventive benefits, the composition is administered to a subject at risk of developing the disease, or to a subject reporting one or more physiological symptoms of the disease, even if the specific disease has not been diagnosed. Treatment by administration of the compounds described herein does not require the involvement of a medical professional.

[0058] Chemical entities having a carbon-carbon double bond or a carbon-nitrogen double bond may exist in Z- or E- form (or cis- or trans- form). Furthermore, some chemical entities may exist in various tautomerized forms. Unless otherwise specified, the compounds described herein are intended to include all Z-, E-, and tautomerized forms as well.

[0059] A "tautomer" refers to a molecule in which a proton shift can occur from one atom of the molecule to another atom of the same molecule. The compounds presented herein exist as tautomers in certain embodiments. In environments where tautomerization is possible, a chemical equilibrium of tautomers exists. The exact ratio of tautomers depends on several factors, including physical conditions, temperature, solvent, and pH. Some examples of tautomer equilibrium include: [ka] These are some examples.

[0060] The compounds disclosed herein, in some embodiments, for example, 2 H, 3 H, 11 C,13 C and / or 14 It is used in different concentrated isotopic forms in which the C content is concentrated. In a particular embodiment, the compound is deuterated at at least one position. Such deuterated forms can be prepared by the procedures described in U.S. Patents 5,846,514 and 6,334,997. As described in U.S. Patents 5,846,514 and 6,334,997, deuteration can improve metabolic stability and / or efficacy, and thus increase the duration of action of the drug.

[0061] Unless otherwise stated, the compounds described herein are intended to include compounds that differ only in the presence of one or more isotopically enriched atoms. For example, one or more protons may be replaced by one or more deuterium (two hydrogen atoms) or tritium (three hydrogen atoms), or a combination thereof, or one or more in the structure. 12 The carbon atom, in its structure, is one or more 13 C atom, one or more 14 Compounds having the structure of the present invention, except that they are replaced by C atoms or combinations thereof, are within the scope of this disclosure.

[0062] The compounds disclosed herein may optionally contain unnatural proportions of atomic isotopes in one or more atoms constituting such compounds. For example, the compounds may include, for example, deuterium ( 2 H), tritium ( 3 H), Iodine-125( 125 I) or carbon-14 ( 14 It can be labeled with one or more isotopes, such as C). 2 H, 11 C, 13 C, 14 C, 15 C, 12 N, 13 N, 15 N, 16 N, 17 O, 18 O, 14 F,15 F, 16 F, 17 F, 18 F, 33 S, 34 S, 35 S, 36 S, 35 Cl, 37 Cl, 79 Br, 81 Br, and 125 All isotopic substitutions by I are intended. All isotopic variants of the compounds of the present invention, whether radioactive or not, are included within the scope of the present invention.

[0063] In certain embodiments, the compounds disclosed herein are 1 Some or all of the H atoms 2 It is replaced by a hydrogen atom. Methods for synthesizing deuterium-containing compounds are known in the art and include, but are not limited to, the following synthesis methods.

[0064] Deuterium-substituted compounds are synthesized using various methods, such as those described in Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0065] Deuterated starting materials are readily available and are subjected to the synthetic methods described herein to provide for the synthesis of deuterium-containing compounds. Many deuterium-containing reagents and components are commercially available from chemical suppliers such as MilliporeSigma.

[0066] This disclosure includes salts, in particular pharmaceutically acceptable salts, of the compounds described herein. Compounds of this disclosure that form salts (in particular pharmaceutically acceptable salts) by comprising one or more sufficiently acidic functional groups, one or more sufficiently basic functional groups, or both one or more sufficiently acidic functional groups and one or more sufficiently basic functional groups, can react with any of several inorganic or organic bases or inorganic or organic acids or combinations thereof to form salts. Alternatively, intrinsically charged compounds, such as compounds having quaternary nitrogen, can form salts with appropriate counterions.

[0067] The compounds and salts described herein may, in some cases, exist as diastereomers, enantiomers, or other stereoisomers. Unless otherwise specified (e.g., in tables of biological data), the structures disclosed herein are intended, explicitly or implicitly, to include all diastereomer (e.g., epimer) forms and enantiomers, as well as mixtures thereof. Separation of stereoisomers may be carried out by chromatography, or by forming diastereomers and separating them by recrystallization, chromatography, or any combination thereof. (Jean Jacques, Andre Collet, Samuel H. Wilen, “Enantiomers, Racemates and Resolutions”, John Wiley And Sons, Inc., 1981, is incorporated herein by reference.) Stereoiomers may also be obtained by stereoselective synthesis.

[0068] In certain embodiments, a compound or a salt of a compound may be a prodrug. For example, in some embodiments, a hydroxyl group in the parent compound is presented as an ester or carbonate, or a carboxylic acid present in the parent compound is presented as an ester. The term “prodrug” is intended to encompass compounds that are converted to the pharmaceuticals of this disclosure under physiological conditions. One method for creating a prodrug involves comprising one or more selected moieties that are hydrolyzed under physiological conditions to expose a desired molecule. In other embodiments, the prodrug is converted by the enzymatic activity of a host animal, such as in specific target cells in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids, and esters of phosphonic acids) may be prodrugs of this disclosure. In some embodiments, amine prodrugs may depend on enzymatic activation. In some embodiments, amine prodrugs may depend on physiological and chemical conditions for drug release. In some embodiments, the amine prodrug may be selected from amides, carbonates, N-acyloxyalkyl derivatives, N-acyloxycarbonyl derivatives, β-aminoketones, (oxodioxolenyl)methyl derivatives, N-Mannich bases, imines (e.g., Schiff bases), enamines, enaminones, azo compounds, lactonizable systems, tetrahydrothiadiazine-2-thione, redox systems, or PEG.

[0069] As described herein, prodrug forms of the compounds described herein that are metabolized in vivo to produce compounds are included in the claims. In some cases, some of the compounds described herein may be prodrugs for other derivatives or active compounds.

[0070] Prodrugs are often useful because, in certain situations, they may be easier to administer than the parent drug. For example, a prodrug may be available when administered orally, whereas the parent drug is not bioavailable when administered orally. Prodrugs can help enhance the cellular permeability of a compound compared to the parent drug. Prodrugs may also have improved solubility in pharmaceutical compositions compared to the parent drug. Prodrugs may be designed as reversible drug derivatives for use as denaturants to enhance drug transport to site-specific tissues or increase intracellular drug retention.

[0071] In some embodiments, the design of the prodrug increases the lipophilicity of the pharmaceutical product. In some embodiments, the design of the prodrug increases its effective water solubility. For example, Fedorak et al., Am.J.Physiol.,269:G210-218(1995), McLoed et al.,Gastroenterol,106:405-413(1994), Hochhaus et al.,Biomed.Chrom.,6:283-286(1992), J.Larsen and H.Bundgaard, Int.J.Pharmaceutics,37,87(1987), J.Larsen et al.,Int.J.Pharmaceutics,47,103(1988), Sinkula et al.,J.Pharm.Sci.,64:181-210(1975), T.Higuchi and V.Stella,Pro-drugs as Novel Delivery Systems,Vol.14 of the ACSSymposium Series, and Edward See B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987 (all such disclosures are incorporated herein by reference). According to another embodiment, the present disclosure provides a method for producing the compounds defined above. The compounds can be synthesized using the prior art. Advantageously, these compounds can be synthesized from readily available starting materials.

[0072] The synthetic chemical transformations and methodologies useful for the synthesis of the compounds described herein are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations (1989), T.W. Greene and P.G. M. Wuts, Protective Groups in Organic Synthesis, 2nd ed. (1991), L. Fieser and M. Fieser, Fieser and Fieser's Reagents for Organic Synthesis (1994), and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis (1995).

[0073] compound The following is a consideration of compounds and salts that may be used in the methods of this disclosure. In certain embodiments, the compounds and salts are represented by formulas (I), (II), and (III).

[0074] In one aspect, in this specification, formula (I): [ka] A compound or salt thereof represented by formula (I) is disclosed, in which: X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected, and here X 1 , X 2 , X 3 , and X 4 At least one of them is N; and X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N; Each R 1 Independently: hydrogen; Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Those that are replaced as needed Selected from; R 2 teeth: C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b)C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Those that are replaced as needed Selected from; R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are substituted as needed with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR 10c , -N(R 10c ) Substituted as needed with one or more substituents independently selected from -NO2 and -CN Selected from; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 7 teeth: Hydrogen, as well as halogens, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; R 8 teeth: Hydrogen; and Halogen, -OR 10e , -SR 10e , -N(R 10e )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10e , -SR 10e , -N(R 10e ) Substituted as needed with one or more substituents independently selected from -NO2 and -CN Selected from; Each R 9a Independently: Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a)2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9c Independently: Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c-NO2, =O, =S, =N(R 10c ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and one or more substituents selected independently of -CN as needed. Selected from; and Each R 10a , R 10b , R 10c , R 10d , and R 10e Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0075] In one aspect, in this specification, formula (I): [ka] A compound or salt thereof represented by formula (I) is disclosed, in which: X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected, and here X 1 , X 2 , X 3 , and X 4 At least one of them is N; and X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N; Each R 1 Independently: hydrogen; Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a, -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Those that are replaced as needed Selected from; R 2 teeth: C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Those that are replaced as needed Selected from; R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are substituted as needed with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR 10c , -N(R 10c ) Substituted as needed with one or more substituents independently selected from -NO2 and -CN Selected from; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9cIt is replaced as needed; R 7 teeth: Hydrogen, as well as halogens, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; R 8 teeth: Hydrogen; and Halogen, -OR 10e , -SR 10e , -N(R 10e )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10e , -SR 10e , -N(R 10e ) Substituted as needed with one or more substituents independently selected from -NO2 and -CN Selected from; Each R 9a Independently: Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9c Independently: Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and one or more substituents selected independently of -CN as needed. Selected from; and Each R 10a , R 10b , R 10c , R 10d , and R 10e Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Here X 3 and X 1 If both are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , -SR 10 , -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups.

[0076] In one aspect, in this specification, formula (IX): [ka] A compound represented by or a salt thereof is disclosed, in formula (IX): X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected, and here X 1 , X 2 , X 3 , and X 4 At least one of them is N; and X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N; Each R 1 Independently: hydrogen; Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a , and -C(O)N(R 10a )2; Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -CN, 1 or more R 9a C replaced as needed 1~6 Substituted as needed with one or more substituents independently selected from the alkyl group. Selected from; R 2 teeth: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -CN, =O,C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, =O, -CN, and C 1~6It is optionally substituted with one or more substituents independently selected from the alkyl group, where each C 1~6 Alkyl groups consist of one or more R 9b Those that are replaced as needed Selected from; R 3 and R 4 Each is independent of the others: Hydrogen and -OH; and Halogen, -OR 10c , -SR 10c , -N(R 10c )2, and C as needed, substituted with one or more substituents independently selected from -CN 1~6 Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and C 1~6 Selected from alkyl groups; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 7 is hydrogen and C 1~6 Selected from alkyl groups; R 8 is hydrogen and C 1~6 Selected from alkyl groups; Each R 9a , R9b , R 9c , independently, halogen, -OH, -OMe, -CN, and C 1~3 Selected from alkyl groups; Each R 10a , R 10b , R 10c , R 10d , and R 10e Independently: hydrogen; Halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 C is a carbon ring, or a 3-membered to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from these carbon rings. 1~6 Alkyl Selected from.

[0077] In one aspect, in this specification, formula (IY): [ka] A compound or salt thereof represented by formula (IY) is disclosed, in which: X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected, and here X 1 , X 2 , X 3 , and X 4 At least one of them is N; and X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N; Each R 1 Independently: Hydrogen, fluoro, chloro, bromo, -CN, -OH, -O(C 1~6 Alkyl), -O(C1~6 Haloalkyl), -O(C 3~10 (Carbon ring), -O (3-membered to 10-membered heterocycle), -C(O)NH2, C 1~6 Alkyl, C 1~6 Haloalkyl and C 3~10 Selected from the carbon ring, here this C 3~10 The carbon ring is replaced as needed with one or more halogens; R 2 teeth: -F, Cl, -OH, and C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from -F, -Cl, and -CN. Selected from; R 3 and R 4 Each is independently selected from: hydrogen, -OH, and methyl; R 5 and R 6 Each of them independently consists of hydrogen and C 1~3 Selected from alkyl groups; R 7 is: Hydrogen and C 1~6 Selected from alkyl groups; R 8 is hydrogen and C 1~6 Selected from alkyl groups; and Each R 9a , R 9b , R 9c These are independently halogen, -OH, -OMe, -CN, and C 1~3 Selected from alkyl groups.

[0078] In certain embodiments, for a compound or salt of formula (I), X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected from. In some embodiments, X 1 , X 2 , X 3 , or X 4 At least one of them is N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected, and here X 1 , X 2 , X 3 , and X 4 At least one of them is N; and X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N. In some embodiments, X 1 , X 2 , X 3 , and X 4 One or less of these is N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Three or fewer of these are N. In some embodiments, X 1 , X 2 , X 3 , or X 4At least one of them is N. In some embodiments, X 1 , X 2 , X 3 , or X 4 At least two of them are N. In some embodiments, X 1 , X 2 , X 3 , or X 4 At least three of them are N. In some embodiments, X 1 , X 2 , X 3 , or X 4 At least one of them is N, and X 1 , X 2 , X 3 , and X 4 Two or fewer of these are N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ), N, and N + (-O - ) is selected from. In some embodiments, X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ) and N are selected. In some embodiments, X 1 , X 2 , X 3 , and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 , X 2 , X 3 , or X 4 One of them is N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Two of these are N. In some embodiments, X 1 , X 2 , X 3 , and X 4Three of these are N. In some embodiments, X 1 , X 2 , X 3 , or X 4 One of them is C(R 1 ) is. In some embodiments, X 1 , X 2 , X 3 , and X 4 Two of them are C(R 1 ) is. In some embodiments, X 1 , X 2 , X 3 , and X 4 Three of them are C(R 1 ) is. In some embodiments, X 1 , X 2 , X 3 , and X 4 Four of them are C(R 1 ) is. In some embodiments, X 1 In some embodiments, X 2 In some embodiments, X 3 In some embodiments, X 4 In some embodiments, X 1 is C(R 1 ) is. In some embodiments, X 2 is C(R 1 ) is. In some embodiments, X 3 is C(R 1 ) is. In some embodiments, X 4 is C(R 1 ) is. In some embodiments, X 1 is C(H). In some embodiments, X 2 is C(H). In some embodiments, X 3 is C(H). In some embodiments, X 4 is C(H). In some embodiments, X 1 , X 2 , X 3 , and X 4Two of these are N. In some embodiments, X 1 , X 2 , X 3 , and X 4 Two of them are N, and two X 1 , X 2 , X 3 , and X 4 Of these, the two N are not bonded to each other (for example, by covalent bonds). In some embodiments, X 1 and X 3 In some embodiments, X 2 and X 4 In some embodiments, X 1 is N, and X 2 , X 3 , and X 4 is C(R 1 ) is. In some embodiments, X 2 is N, and X 1 , X 3 , and X 4 is C(R 1 ) is. In some embodiments, X 3 is N, and X 1 , X 2 , and X 4 is C(R 1 ) is. In some embodiments, X 4 is N, and X 1 , X 2 , and X 3 is C(R 1 ) is. In some embodiments, X 1 is N, and X 2 , X 3 , and X 4 is C(H). In some embodiments, X 2 is N, and X 1 , X 3 , and X 4 is C(H). In some embodiments, X 3 is N, and X 1 , X 2 , and X 4is C(H). In some embodiments, X 4 is N, and X 1 , X 2 , and X 3 is C(H).

[0079] In some embodiments, X 2 is N, and X 1 is C(CF3). In some embodiments, X 2 is N, and X 1 is C(CF3), and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and R 2 teeth, [ka] In some embodiments, X 2 is N, and R 2 teeth, [ka] And X 1 is C(CF3). In some embodiments, X 2 is N, and R 2 teeth, [ka] X 1 C(CF3) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and X 1 is C(CN). In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and R 2teeth, [ka] In some embodiments, X 2 is N, and R 2 teeth, [ka] And X 1 is C(F). In some embodiments, X 2 is N, and R 2 teeth, [ka] X 1 C(F) and X 3 is C(H), and X 4 is C(H).

[0080] In some embodiments, X 2 is C(O(C 1~6 It is alkyl. In some embodiments, X 2 is C(OMe). In some embodiments, X 1 is N, and X 2 is C(O(C 1~6 It is alkyl. In some embodiments, X 1 is N and X 2 is C(O(C 1~6 Alkyl)) and X 3 is C(H), and X 4 C(H). In some embodiments, X 1 is N, and X 2 is C(OMe). In some embodiments, X 1 is N, and X 2 is C(OMe) and X 3 is C(H), and X 4 C(H). In some embodiments, X 1 is N, and X 2 is C(O(C 1~6It is alkyl)) and R 3 and R 4 Together with it, it forms a cyclopropyl. In some embodiments, X 1 is N, and X 2 is C(O(C 1~6 Alkyl)) and X 3 is C(H), and X 4 C(H), and R 3 and R 4 Together with it, it forms a cyclopropyl. In some embodiments, X 1 is N, and X 2 is C(OMe), and R 3 and R 4 Together with it, it forms a cyclopropyl. In some embodiments, X 1 is N, and X 2 is C(OMe) and X 3 is C(H), and X 4 C(H), and R 3 and R 4 Together with it, it forms a cyclopropyl group.

[0081] In some embodiments, X 2 is N, and X 1 is C(F). In some embodiments, X 2 is N, and X 1 C(F) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and R 2 teeth, [ka] In some embodiments, X 2 is N, and R 2 teeth, [ka] And X 1is C(F). In some embodiments, X 2 is N, and R 2 teeth, [ka] X 1 C(F) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and X 1 is C(Cl). In some embodiments, X 2 is N, and X 1 is C(Cl), and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and R 2 teeth, [ka] And X 1 is C(Cl). In some embodiments, X 2 is N, and R 2 teeth, [ka] X 1 is C(Cl), and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and X 1 is C(CN). In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and R 2 teeth, [ka] In some embodiments, X 2 is N, and R 2 teeth, [ka] And X 1 is C(CN). In some embodiments, X 2 is N, and R 2 teeth, [ka] X 1 C(CN) and X 3 is C(H), and X 4 is C(H).

[0082] In some embodiments, X 2 , X 3 , and X 4 Each is independently selected from C(H). In some embodiments, X 1 is N, and X 2 , X 3 , and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 is N, and X 2 , X 3 , and X 4 Each is independently selected from C(H). In some embodiments, X 1 is N, and X 2 , X 3 , and X 4 Each is independent of C(R 1 ) is selected from, and R 3 and R 4 Together with it, it forms a cyclopropyl. In some embodiments, X 1 is N, and X 2 , X 3 , and X 4 Each is independently selected from C(H), and R 3 and R4 Together with it, it forms a cyclopropyl group.

[0083] In some embodiments, X 2 is C(CN). In some embodiments, X 1 is N, and X 2 is C(Cl). In some embodiments, X 1 is N, and X 2 is C(Cl), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 is N, and X 2 is C(Cl), and X 3 and X 4 Each is independently selected from C(H).

[0084] In some embodiments, X 1 is N, and X 2 is C(CN). In some embodiments, X 1 is N, and X 2 is C(CN), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 is N, and X 2 is C(CN), and X 3 and X 4 Each is independently selected from C(H).

[0085] In some embodiments, X 1 is C(Br). In some embodiments, X 1 is N, and X 2 is C(Br). In some embodiments, X 1 is N, and X 2 is C(Br), and X 3 and X 4 Each is independent of C(R1 ) is selected from. In some embodiments, X 1 is N, and X 2 is C(Br), and X 3 and X 4 Each is independently selected from C(H). In some embodiments, X 1 is N, and X 2 is C(Br), and R 5 H is H, and R 6 is methyl. In some embodiments, X 1 is N, and X 2 is C(Br), and X 3 and X 4 Each is independent of C(R 1 ) is selected from, and R 5 H is H, and R 6 is methyl. In some embodiments, X 1 is N, and X 2 is C(Br), and X 3 and X 4 Each is independently selected from C(H), and R 5 H is H, and R 6 It is methyl.

[0086] In some embodiments, X 2 is C(F). In some embodiments, X 1 is N, and X 2 is C(F). In some embodiments, X 1 is N, and X 2 is C(F), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 is N, and X 2 is C(F), and X 3 and X 4 Each is independently selected from C(H).

[0087] In some embodiments, X 1 is C(CF3). In some embodiments, X 2 is N, and X 1 is C(CF3). In some embodiments, X 2 is N, and X 1 is C(CF3), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 2 is N, and X 1 is C(CF3), and X 3 and X 4 Each is independently selected from C(H).

[0088] In some embodiments, X 1 is C(OCF3). In some embodiments, X 2 is N, and X 1 is C(OCF3). In some embodiments, X 2 is N, and X 1 is C(OCF3), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 2 is N, and X 1 is C(OCF3), and X 3 and X 4 Each is independently selected from C(H).

[0089] In some embodiments, X 2 is N, and X 1 is C(CN). In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 2 is N, and R 2 teeth, [ka] In some embodiments, X 2 is N, and R 2 teeth, [ka] And X 1 is C(CN). In some embodiments, X 2 is N, and R 2 teeth, [ka] X 1 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and X 2 is C(OR 10a ) is. In some embodiments, X 1 is N, and X 2 is C(OMe). In some embodiments, X 1 is N, and X 2 is C(OR 10a ) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and X 2 is C(OMe) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] And X 2 is C(OR 10a ) is. In some embodiments, X 1 is N, and R 2 teeth, [ka] And X 2 is C(OMe). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 is C(OR 10a ) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 is C(OMe) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 is C(OMe) and X 3 is C(H) and X 4 is C(H), and R 3 and R 4 Together with it, it forms a cyclopropyl ring. In some embodiments, X 1 is N, and X 2 is C(H) and X 3 is C(H), and X 4 is C(H). In some embodiments, X1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 3 is C(H) and X 4 is C(H), and R 3 and R 4 Together with it, it forms a cyclopropyl ring. In some embodiments, X 1 is N, and X 2 is C(Cl). In some embodiments, X 1 is N, and X 2 is C(Cl), and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] And X 2 is C(CN). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and X 2 is C(CN). In some embodiments, X 1 is N, and X 2 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] And X 2 is C(CN). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 C(CN) and X 3 is C(H) and X 4 is C(H), and R 3 and R4 Together with it, it forms a cyclopropyl ring. In some embodiments, X 1 is N, and X 2 is C(H) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] And X 2 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 is C(H) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and X 2 is C(CN). In some embodiments, X 1 is N, and X 2 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 is C(CN). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 C(CN) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and X 2 is C(F). In some embodiments, X 1 is N, and X 2 C(F) and X 3 is C(H), and X 4 is C(H). In some embodiments, X 1 is N, and R 2 teeth, [ka] In some embodiments, X 1 is N, and R 2 teeth, [ka] And X 2 is C(F). In some embodiments, X 1 is N, and R 2 teeth, [ka] X 2 C(F) and X 3 is C(H), and X 4 is C(H).

[0090] In some embodiments, X 2 is C(F). In some embodiments, for a compound or salt of formula (I), X 1is N, and X 2 F is R 5 is methyl, and R 6 It is hydrogen.

[0091] In some embodiments, X 2 is C(CF3). In some embodiments, X 1 is N, and X 2 is C(CF3). In some embodiments, X 1 is N, and X 2 is C(CF3), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 is N, and X 2 is C(CF3), and X 3 and X 4 Each is independently selected from C(H).

[0092] In some embodiments, X 1 is C(Cl). In some embodiments, X 3 is N, and X 1 is C(R 1 ) is. In some embodiments, X 3 is N, and X 1 is C(R 1 ) and X 2 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 3 is N, and X 1 is C(Cl). In some embodiments, X 3 is N, and X 1 is C(Cl), and X 2 is C(R 1 ) is. In some embodiments, X 3 is N, and X 1 is C(Cl), and X 2 is C(R 1) and X 4 is C(R 1 ) is. In some embodiments, X 3 is N, and X 1 is C(Cl), and X 2 is C(H). In some embodiments, X 3 is N, and X 1 is C(Cl), and X 2 is C(H), and X 4 is C(H).

[0093] In some embodiments, X 1 is C(OCH2CHF2) (for example, in some embodiments, X 1 ( is a carbon having a 2,2-difluoroethoxy moiety). In some embodiments, X 2 is N, and X 1 is C(OCH2CHF2). In some embodiments, X 2 is N, and X 1 is C(OCH2CHF2), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 2 is N, and X 1 is C(OCH2CHF2), and X 3 and X 4 Each is independently selected from C(H).

[0094] In some embodiments, X 1 is C(OCH2CH3). In some embodiments, X 2 is N, and X 1 is C(OCH2CH3). In some embodiments, X 2 is N, and X 1 is C(OCH2CH3), and X 3 and X 4 Each is independent of C(R 1) is selected from. In some embodiments, X 2 is N, and X 1 is C(OCH2CH3), and X 3 and X 4 Each is independently selected from C(H).

[0095] In some embodiments, X 2 is C(OCH2CH3). In some embodiments, X 1 is N, and X 2 is C(OCH2CH3). In some embodiments, X 1 is N, and X 2 is C(OCH2CH3), and X 3 and X 4 Each is independent of C(R 1 ) is selected from. In some embodiments, X 1 is N, and X 2 is C(OCH2CH3), and X 3 and X 4 Each is independently selected from C(H).

[0096] In some embodiments, X 1 teeth, [ka] In some embodiments, X 2 is N, and X 1 teeth, [ka] In some embodiments, X 2 is N, and X 1 teeth, [ka] And X 3 and X 4 Each is independent of C(R 1) is selected from. In some embodiments, X 2 is N, and X 1 teeth, [ka] And X 3 and X 4 Each is independently selected from C(H).

[0097] In certain embodiments, for a compound or salt of formula (I), each R 1 Independently: hydrogen; Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a)C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Those that are replaced as needed Selected from.

[0098] In certain embodiments, for a compound or salt of formula (I), each R 1These are independently: hydrogen; halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a , and -C(O)N(R 10a )2; Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -CN, 1 or more R 9a C replaced as needed 1~6 The alkyl group is selected from those that are optionally substituted with one or more substituents, independently of the alkyl group.

[0099] In some embodiments, each R 1 These are independently: hydrogen; halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a , and -C(O)N(R 10a )2; Halogen, -OR 10a , -SR 10a , and -N(R 10a )C which is optionally substituted with one or more substituents independently selected from 2 1~6 Alkyl; and C 3~10Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , and -N(R 10a ) Selected independently of 2, and substituted as needed with one or more substituents.

[0100] In some embodiments, each R 1 These are independently: hydrogen; halogen, CN, -OR 10a , and -C(O)N(R 10a )2; C as needed, substituted with one or more substituents independently selected from halogens 1~6 C as needed, substituted with one or more substituents independently selected from alkyl and halogens. 3~10 Selected from the carbocyclic ring.

[0101] In some embodiments, R 1 It is independently selected from hydrogen.

[0102] In some embodiments, each R 1 These are independently hydrogen, halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a Selected from;

[0103] In some embodiments, each R 1 Hydrogen and C are independent of each other. 1~6 Alkyl, C2~6 Alkenyl and C 2~6 Selected from alkynnyls, each of these being halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a It is replaced as needed.

[0104] In some embodiments, each R 1 Hydrogen and C are independent of each other. 3~10 Selected from carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a It is replaced as needed.

[0105] In some embodiments, each R 1 These are independently: hydrogen; halogen, -NO2, -CN, -CN, -OH, -SH, -NO2, -NH2, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2, and -NH(C 1~6 Alkyl); C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, each of which is a halogen, -NO2, -CN, -CN, -OH, -SH, -NO2, -NH2, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 substituted as needed with one or more substituents independently selected from carbon rings and 3- to 10-membered heterocycles; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -NO2, -CN, -CN, -OH, -SH, -NO2, -NH2, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6The alkynyl is selected from those which may be substituted as needed with one or more substituents independently selected.

[0106] In some embodiments, each R 1 These are independently halogen, -NO2, -CN, -CN, -OH, -SH, -NO2, -NH2, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~3 Selected from alkyl groups. In some embodiments, each R 1 C 3~5 Selected from the carbon ring, including halogens, -NO2, -CN, -CN, -OH, -SH, -NO2, -NH2, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl. In some embodiments, each R 1 These are independently hydrogen, -CN, -OH, -OMe, -OEt, -OiPr, -F, -Cl, -Br, -Me, -Et, -CF3, -CHF2, -CH2F, OCF3, -OCHF2, -OCH2F, -C(O)NH2, [ka] Selected from. In some embodiments, each R 1 These are independently hydrogen, -CN, -OH, -OMe, -OEt, -OiPr, -F, -Cl, -Br, -Me, -Et, -CF3, -CHF2, -CH2F, OCF3, -C(O)NH2, [ka] Selected from. In some embodiments, each R 1 These are independently hydrogen, -CN, -OH, -OMe, -OEt, -OiPr, -F, -Cl, -Br, -Me, -Et, -CF3, OCF3, -C(O)NH2, [ka] Selected from. In some embodiments, each R 1 These are independently hydrogen, -CN, -OH, -OMe, -OEt, -OiPr, -F, -Cl, -Br, -Me, -CF3, OCF3, -C(O)NH2, [ka] Selected from. In some embodiments, each R 1 These are independently hydrogen, -CF3, -CN, and -OR 10a Selected from (e.g., -OMe), -F, -Cl, -OCF3, and methyl. In some embodiments, each R 1 R is independently selected from hydrogen, -CF3, -CN, -OMe, -F, -Cl, -OCF3, and methyl. In some embodiments, each R 1 These are independently hydrogen, -CF3, -CN, and -OR 10a (For example, selected from -OMe), -F, -Cl, and -OCF3. In some embodiments, each R 1 R is independently selected from hydrogen, -CF3, -CN, -OMe, -F, -Cl, and -OCF3. In some embodiments, each R 1 R is independently selected from hydrogen, -CF3, -CN, -OMe, -F, and -Cl. In some embodiments, each R 1 R is independently selected from hydrogen, -CF3, -CN, -OMe, and -F. In some embodiments, each R 1 R is independently selected from hydrogen, -CF3, -CN, and -OMe. In some embodiments, each R 1 R is independently selected from hydrogen, -CF3, and -CN. In some embodiments, each R1 R is independently selected from hydrogen and -CN. In some embodiments, each R 1 R is independently selected from hydrogen and -CF3. In some embodiments, each R 1 R is independently selected from hydrogen and -CN. In some embodiments, each R 1 These are independently hydrogen and -OR 10a Selected from. In some embodiments, each R 1 R is independently selected from hydrogen and -OMe. In some embodiments, each R 1 R is independently selected from hydrogen and -F. In some embodiments, each R 1 R is independently selected from hydrogen and -Cl. In some embodiments, each R 1 R is independently selected from hydrogen and -OCF3. In some embodiments, each R 1 Hydrogen and C are independent of each other. 1~6 Selected from alkyl groups. In some embodiments, each R 1 R is independently selected from hydrogen and methyl. In some embodiments, each R 1 R is independently selected from hydrogen, F, and CN. In some embodiments, each R 1 R is independently selected from hydrogen and CF2H. In some embodiments, each R 1 R is independently selected from hydrogen, halogen, and -CN. In some embodiments, each R 1 R is independently selected from hydrogen, F, and -CN. In some embodiments, each R 1 R is independently selected from hydrogen and F. In some embodiments, each R 1 R is independently selected from hydrogen and CN. In some embodiments, each R 1 It is independently selected from hydrogen.

[0107] In certain embodiments, for a compound or salt of formula (I), R 2 ha:C 1~6 Alkyl, C 2~6Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0108] In some embodiments, R 2 C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0109] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0110] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0111] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b-NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0112] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, C 1~6 Alkyl, C 2~6Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0113] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b-NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 is halogen, -OR 10b , -N(R 10b )2, -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9bIt is replaced as needed. In some embodiments, R 2 is halogen, -OR 10b , C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 F, OH, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 F, OH, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, where each C 3~10 The carbocyclic and 3- to 10-membered heterocycles are independently selected from phenyl, 2-pyridyl, and 3-pyridyl, and each of phenyl, 2-pyridyl, and 3-pyridyl has one or more R 9b It is replaced as needed. In some embodiments, R 2 is halogen, -OR 10b , C 3~10 A C2 alkyl group, optionally substituted with one or more substituents independently selected from a carbocyclic and a 3- to 10-membered heterocycle, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 F, OH, C 3~10A C2 alkyl group, optionally substituted with one or more substituents independently selected from a carbocyclic and a 3- to 10-membered heterocycle, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b It is replaced as needed. In some embodiments, R 2 F, OH, C 3~10 A C2 alkyl group optionally substituted with one or more substituents independently selected from a carbocyclic and a 3- to 10-membered heterocycle, where each C 3~10 The carbocyclic and 3- to 10-membered heterocycles are independently selected from phenyl, 2-pyridyl, and 3-pyridyl, and each of phenyl, 2-pyridyl, and 3-pyridyl has one or more R 9b It is replaced as needed.

[0114] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b It is then selected from the options that have been replaced as needed.

[0115] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group, where each C 1~6 Alkyl groups consist of one or more R 9bIt is then selected from the options that have been replaced as needed.

[0116] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, and C 1~6 The alkyl group is selected from those that are optionally substituted with one or more substituents, independently of the alkyl group.

[0117] In some embodiments, R 2 is halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, and C 1~6The alkyl group is selected from those that are optionally substituted with one or more substituents, independently of the alkyl group.

[0118] In some embodiments, R 2 is halogen, -OR 10b , -N(R 10b )2, -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, -CN, and C 1~6 The alkyl group is selected from those that are optionally substituted with one or more substituents, independently of the alkyl group.

[0119] In some embodiments, R 2 is halogen, -OR 10b , C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 The selection includes carbon rings and 3- to 10-membered heterocycles, each of which is optionally substituted with halogens and one or more substituents independently selected from -CN.

[0120] In some embodiments, R 2 F, OH, C 3~10C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 The selection includes carbon rings and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from F and -CN.

[0121] In some embodiments, R 2 F, OH, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 The carbocyclic and 3- to 10-membered heterocycles are independently selected from phenyl, 2-pyridyl, and 3-pyridyl, and each of phenyl, 2-pyridyl, and 3-pyridyl has one or more R 9b Those which are replaced as necessary; and C 3~10 The selection includes carbon rings and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from F and -CN.

[0122] In some embodiments, R 2 is halogen, -OR 10b , C 3~10 A C2 alkyl group optionally substituted with one or more substituents independently selected from a carbocyclic and a 3-membered to 10-membered heterocycle, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10The selection includes carbon rings and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from F and -CN.

[0123] In some embodiments, R 2 F, OH, C 3~10 A C2 alkyl group optionally substituted with one or more substituents independently selected from a carbocyclic and a 3-membered to 10-membered heterocycle, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 The selection includes carbon rings and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from F and -CN.

[0124] In some embodiments, R 2 The following: [ka] A substituent represented by, where Q 1 C is optionally substituted with one or more substituents selected from OH and halo. 1~3 It is alkyl; Y 1 and Y 2 Each of them is independent of N and C(Q). 3 ) is selected from; and each Q 2 They are independently selected from Halo and CN; each Q 3 n is independently selected from hydrogen, halo, and CN; and n is 0, 1, or 2.

[0125] In some embodiments, Q 1 Q is a C1 alkyl group optionally substituted with one or more substituents selected from OH and fluoro; each Q 2 These are independently selected from fluoro and CN; and each Q 3Q is independently selected from hydrogen, fluoro and CN. In some embodiments, each Q 2 Q is selected from F and H. In some embodiments, each Q 2 Q is selected from CN and H. In some embodiments, each Q 3 is selected from F. In some embodiments, each Q 3 Q is selected from F and H. In some embodiments, each Q 3 Q is selected from CN and H. In some embodiments, each Q 3 It is selected from F.

[0126] In some embodiments, R 2 teeth, [ka] Selected from. In some embodiments, R 2 teeth, [ka] Selected from.

[0127] In some embodiments, R 2 OH and C 3~10 A carbon ring is optionally substituted with one or more substituents independently selected from the carbon ring. 1~6 It is alkyl, and here this C 3~10 The carbocyclic ring is optionally substituted with one or more substituents independently selected from halogens and -CN; and C is optionally substituted with one or more substituents independently selected from halogens and -CN. 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 2 is one or more C 3~10 C substituted as needed in the carbon ring 1~6 It is an alkyl group, where each C 3~10The carbocyclic ring is optionally substituted with one or more substituents independently selected from halogens and -CN; and C is optionally substituted with one or more substituents independently selected from halogens and -CN. 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 2 is one or more C 3~10 C substituted as needed in the carbon ring 1~6 It is an alkyl group, where each C 3~10 The carbocyclic ring is optionally substituted with one or more substituents independently selected from F and -CN; and C is optionally substituted with one or more substituents independently selected from -F and -CN. 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 2 is one or more C 3~10 A C2 alkyl group optionally substituted with a carbon ring, where each C 3~10 The carbocyclic ring is optionally substituted with one or more substituents independently selected from halogens and -CN; and C is optionally substituted with one or more substituents independently selected from halogens and -CN. 3~10 They are selected from carbocyclic rings and 3- to 10-membered heterocycles.

[0128] In some embodiments, R 2 is one or more C 3~10 A C2 alkyl group optionally substituted with a carbon ring, where each C 3~10 The carbocyclic ring is optionally substituted with one or more substituents independently selected from -F and -CN; and C is optionally substituted with one or more substituents independently selected from -F and -CN. 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 2 is one or more C 3~10A C2 alkyl group with a carbon ring substituted as needed, where each C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from -F and -CN. In some embodiments, R 2 is one or more C 3~10 A C2 alkyl group with a carbon ring substituted as needed, where each C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from -F. In some embodiments, R 2 is one or more C 3~10 A C2 alkyl group with a carbon ring substituted as needed, where each C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from -CN.

[0129] In some embodiments, R 2 C is optionally substituted with one or more substituents independently selected from -F and -CN. 3~10 They are carbon rings and 3- to 10-membered heterocycles.

[0130] In certain embodiments, for a compound or salt of formula (I), R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed.

[0131] In some embodiments, R 3 and R 4 Each is independent of: hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; as well as halogens, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl groups; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed.

[0132] In some embodiments, R 3 and R 4 Each is independently: hydrogen, halogen, -NO2, and -CN; as well as C substituted as needed with one or more halogens. 1~6 Selected from alkyl groups; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed. In some embodiments, R 3 and R 4 Each is independently: hydrogen, halogen, -NO2, and -CN; as well as C substituted as needed with one or more halogens. 1~6 Selected from alkyl groups; or R3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring.

[0133] In some embodiments, R 3 and R 4 Each is independently: hydrogen; and C, which is substituted as needed with one or more halogens. 1~6 Selected from alkyl groups; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring. In some embodiments, R 3 and R 4 Each is independently: hydrogen; and C, which is substituted as needed with one or more halogens. 1~6 Selected from alkyl. In some embodiments, R 3 and R 4 Each is independently: hydrogen; and C 1~6 Selected from alkyl. In some embodiments, R 3 and R 4 Each is independently selected from: hydrogen; and C1 alkyl. In some embodiments, R 3 and R 4 Each is independently selected from hydrogen.

[0134] In some embodiments, R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring. In some embodiments, R 4 R 3 A 3- to 10-membered heterocycle or C formed by 3~10 The carbocyclic ring is selected from cyclopropyl and oxetanyl. In some embodiments, R 3 and R 4 Each is independently selected from: hydrogen; and C1 alkyl; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10It forms a carbon ring. In some embodiments, R 3 and R 4 Each is independently selected from: hydrogen; and C1 alkyl; or R 3 is R 4 Together with C 3~10 It forms a carbon ring. In some embodiments, R 3 and R 4 Each is independently selected from: hydrogen; and C1 alkyl; or R 3 is R 4 Together with C 3~10 It forms a carbon ring, and here this C 3~10 The carbon ring is cyclopropane.

[0135] In some embodiments, R 3 and R 4 Each of these is hydrogen. In some embodiments, R 3 is hydrogen. In some embodiments, R 4 is hydrogen. In some embodiments, R 3 is hydrogen, and R 4 is methyl. In some embodiments, R 3 is hydrogen, and R 4 is C 1~6 It is alkyl. In some embodiments, R 3 is -H, and R 4 is -OH. In some embodiments, R 3 is -OH, and R 4 is -H. In some embodiments, R 3 It is -OH.

[0136] In certain embodiments, for a compound or salt of formula (I), R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; Halogen, -OR10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are substituted as needed with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR 10c , -N(R 10c ) Selected from those independently selected from -NO2 and -CN, which are substituted as needed with one or more substituents; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed.

[0137] In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 Selected from alkyl groups, where each C 3~10Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed.

[0138] In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and C 1~6 Selected from alkyl groups; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed. In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and C 1~6 Selected from alkyl. In some embodiments, R 5 and R 6 These are independently: hydrogen and C 1~3 Selected from alkyl. In some embodiments, R 5 is hydrogen. In some embodiments, R 6 is hydrogen. In some embodiments, R 5 and R 6Each of these is hydrogen. In some embodiments, R 5 is hydrogen, and R 6 C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl. In some embodiments, R 5 is hydrogen, and R 6 It is methyl.

[0139] In some embodiments, the compound or salt of formula (I) is formula (IQ): [ka] It is a compound or salt of formula (IQ). In some embodiments, the compound or salt of formula (IQ) is an activator of skeletal myosin. In some embodiments, the compound or salt of formula (IQ) is used to treat obesity or to induce weight loss. In some embodiments, for the compound or salt of formula (IQ), R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~10 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are optionally substituted with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR10c , -N(R 10c )2, -NO2, and -CN are selected independently and optionally substituted with one or more substituents. In some embodiments, R 5 is -H, and R 6 is: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~10 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are optionally substituted with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are selected independently and optionally substituted with one or more substituents. In some embodiments, R 5 is -H, and R 6 is: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~10 Selected from alkyl groups, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R5 is -H, and R 6 is: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 Selected from alkyl groups, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R 6 is halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Branched (e.g., non-linear, e.g., primary, secondary, or tertiary) carbon rings, optionally substituted with one or more substituents independently selected from 3- to 10-membered heterocycles. 1~6 It is alkyl, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R 6 is halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10A methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety, where each C is optionally substituted with one or more substituents independently selected from a carbon ring and a 3- to 10-membered heterocycle. 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R 6 C 3~10 A methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety, where each C is optionally substituted with one or more substituents independently selected from the carbon ring. 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from halogens and -CN. In some embodiments, R 5 is -H, and R 6 C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from the carbon ring, and is a methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety. In some embodiments, R 5 is -H, and R 6The moiety is n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl.

[0140] In certain embodiments, for a compound or salt of formula (I), R 7 H: Hydrogen, as well as halogens, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl. In some embodiments, R 7 This includes hydrogen, as well as halogens, CN, and C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 Selected from alkyl. In some embodiments, R 7 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from halogens and CN. 1~6 Selected from alkyl. In some embodiments, R 7 C is optionally substituted with one or more substituents independently selected from hydrogen and halogens. 1~6 Selected from alkyl. In some embodiments, R 7 is hydrogen and C 1~6 Selected from alkyl. In some embodiments, R 7 R is selected from hydrogen and methyl. In some embodiments, R 7 It is selected from hydrogen.

[0141] In certain embodiments, for a compound or salt of formula (I), R 8 teeth: Hydrogen; and Halogen, -OR 10e , -SR 10e , -N(R10e )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10e , -SR 10e , -N(R 10e ) Substituted as needed with one or more substituents independently selected from -NO2 and -CN Selected from.

[0142] In some embodiments, R 8 is: hydrogen; as well as halogens, -OR 10e , -SR 10e , -N(R 10e )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl. In some embodiments, R 8 This includes hydrogen, as well as halogens, CN, and C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 Selected from alkyl. In some embodiments, R 8 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from halogens and CN. 1~6 Selected from alkyl. In some embodiments, R 8 C is optionally substituted with one or more substituents independently selected from hydrogen and halogens. 1~6 Selected from alkyl. In some embodiments, R 8 is hydrogen and C 1~6 Selected from alkyl. In some embodiments, R 8 It is selected from hydrogen.

[0143] In certain embodiments, for a compound or salt of formula (I), each R 9a Independently: Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and one or more substituents selected independently of -CN as needed. Selected from.

[0144] In some embodiments, each R9a These are independently: halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a Selected from those which are optionally substituted with one or more substituents independently selected from -NO2, =O, and -CN. In some embodiments, each R 9a These are independently: halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, and -CN; as well as halogens, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9a These are independently: F, Cl, Br, -OR 10a , -N(R 10a )2, -NO2, =O, and -CN; as well as F, Cl, Br, -OR 10a , -N(R 10a )C as needed, substituted with one or more substituents independently selected from -NO2, -O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9a These are independently: F, Cl, -OR 10a , -N(R 10a )2, -NO2, =O, and -CN; as well as F, Cl, -OR 10a , -N(R 10a)C as needed, substituted with one or more substituents independently selected from -NO2, -O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9a F, Cl, -NO2, =O, and -CN are independently substituted with one or more substituents independently selected from F, Cl, -NO2, =O, and -CN as needed. 1~3 Selected from alkyl groups. In some embodiments, each R 9a F, Cl, and -CN are independently substituted with one or more substituents independently selected from F, Cl, and -CN as needed. 1~3 Selected from alkyl groups. In some embodiments, each R 9a These are independently: F, Cl, and -CN; and C 1~3 Selected from alkyl groups. In some embodiments, each R 9a These are independently: F and -CN; and C 1~3 Selected from alkyl groups. In some embodiments, each R 9a R is independently selected from F and -CN. In some embodiments, each R 9a R is independently selected from F. In some embodiments, each R 9a It is selected independently from :-CN.

[0145] In certain embodiments, for a compound or salt of formula (I), each R 9b These are independently: halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; as well as C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and are selected as needed to be substituted with one or more substituents independently selected from -CN. In some embodiments, each R 9b These are independently: halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b Selected from those which are optionally substituted with one or more substituents independently selected from -NO2, =O, and -CN. In some embodiments, each R 9b These are independently: halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, and -CN; as well as halogens, -OR 10b , -SR 10b , -N(R 10b )C as needed, substituted with one or more substituents independently selected from -NO2, -O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9b These are independently: halogen, -OR 10b , -SR 10b , -N(R 10b )2, -NO2, =O, and -CN; as well as halogens, -OR 10b , -SR 10b , -N(R 10b )C as needed, substituted with one or more substituents independently selected from -NO2, -O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9b R is independently selected from halogen and -CN. In some embodiments, each R 9b R is independently selected from -F, -Cl, and -CN. In some embodiments, each R 9b These are independently selected from -F and -CN. In some embodiments, each R 9b R is independently selected from -F. In some embodiments, each R 9b It is selected independently from -CN.

[0146] In certain embodiments, for a compound or salt of formula (I), each R 9c These are independently: halogen, -OR 10c, -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; as well as C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and are selected as needed to be substituted with one or more substituents independently selected from -CN. In some embodiments, each R 9c These are independently halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c -NO2, =O, and -CN; and C 1~3 Alkyl, C 2~3Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c Selected from those which are optionally substituted with one or more substituents independently selected from -NO2, =O, and -CN. In some embodiments, each R 9c These are independently halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c -NO2, =O, and -CN; as well as halogens, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9c These are independently F, Cl, Br, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c -NO2, =O, and -CN; as well as F, Cl, Br, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9c These are independently F, Cl, and -OR. 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c -NO2, =O, and -CN; as well as F, Cl, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10cC as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9c These are independently F, Cl, Br, -OR 10c , -N(R 10c )2, -C(O)R 10c -NO2, =O, and -CN; as well as F, Cl, Br, -OR 10c , -N(R 10c )2, -C(O)R 10c C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9c F, Cl, Br, -NO2, =O, and -CN are independently substituted with one or more substituents independently selected from F, Cl, Br, -NO2, =O, and -CN, as needed. 1~3 Selected from alkyl groups. In some embodiments, each R 9c F, Cl, -NO2, =O, and -CN are independently substituted with one or more substituents independently selected from F, Cl, -NO2, =O, and -CN as needed. 1~3 Selected from alkyl groups. In some embodiments, each R 9c F, Cl, and -CN are independently substituted with one or more substituents independently selected from F, Cl, and -CN as needed. 1~3 Selected from alkyl groups. In some embodiments, each R 9c These are independently: F, Cl, and -CN; and C 1~3 Selected from alkyl groups. In some embodiments, each R 9c These are independently: F and -CN; and C 1~3 Selected from alkyl groups. In some embodiments, each R 9c R is independently selected from F and -CN. In some embodiments, each R 9cR is independently selected from F. In some embodiments, each R 9c It is selected independently from :-CN.

[0147] In certain embodiments, for a compound or salt of formula (I), each R 10a , R 10b , R 10c , R 10d , and R 10e Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0148] In certain embodiments, for a compound or salt of formula (I), each R 10a Independently: Hydrogen; C 1~6 Alkyl, C 2~6Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon rings, substituted as needed with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, each R 10a These are independently hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -N(C 1~6 Alkyl)2, and -NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, and C 1~6Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, each R 10a C is independently hydrogen; and C is optionally substituted with one or more substituents independently selected from halogens, -CN, -OH, -SH, -NO2, -NH2, and =O. 1~6 Alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, R 10a C is independently substituted with hydrogen, and optionally with one or more substituents independently selected from halogens. 1~6 Alkyl; and C 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 10a C is independently substituted with hydrogen, as well as one or more substituents independently selected from fluorine and chlorine, as needed. 1~6 Alkyl; and C 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 10a These are independently hydrogen; and C, which is optionally substituted with fluorine. 1~6 Alkyl; and C 3~10 Selected from carbon rings and 3- to 10-membered heterocycles. In some embodiments, R 10a These are independently hydrogen; and C, which is optionally substituted with fluorine. 1~6 Alkyl; and C 3~10 Selected from a carbocyclic ring and a 3- to 10-membered heterocycle selected from cyclopropane and oxetane. In some embodiments, R 10ais hydrogen. In some embodiments, R 10a It is methyl.

[0149] In certain embodiments, for a compound or salt of formula (I), each R 10b Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0150] In some embodiments, each R 10b These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2, and -NH(C 1~6C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, each R 10b Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10b is hydrogen. In some embodiments, R 10b It is methyl.

[0151] In certain embodiments, for a compound or salt of formula (I), each R 10c Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0152] In some embodiments, each R 10c Independently, hydrogen; halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10c Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10c is hydrogen. In some embodiments, R 10c It is methyl.

[0153] In certain embodiments, for a compound or salt of formula (I), each R 10d Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0154] In some embodiments, each R 10d Independently, hydrogen; halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10d Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10d is hydrogen. In some embodiments, R 10d It is methyl.

[0155] In certain embodiments, for a compound or salt of formula (I), each R 10e Independently: hydrogen; C 1~6 Alkyl, C 2~6Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0156] In some embodiments, each R 10e Independently, hydrogen; halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10e Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10eis hydrogen. In some embodiments, R 10e It is methyl.

[0157] In certain embodiments, for a compound or salt of formula (I), X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , -SR 10 , -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , and C, which may be substituted as needed with one or more substituents independently selected from -CN. 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 8 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from fluoro, -OH, and -CN. 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 8 is hydrogen and C 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 8X is selected from hydrogen and C1 alkyl. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 8 It is selected from hydrogen.

[0158] In certain embodiments, for a compound or salt of formula (I), X 3 and X 1 If both are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , -SR 10 , -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , and C, which may be substituted as needed with one or more substituents independently selected from -CN. 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 8 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from fluoro, -OH, and -CN. 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 8 is hydrogen and C 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 8 X is selected from hydrogen and C1 alkyl. In some embodiments, X 3 and X 1 If both are N, then R 8It is selected from hydrogen.

[0159] In certain embodiments, for a compound or salt of formula (I), X 2 and X 4 If both are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , -SR 10 , -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 8 This includes hydrogen, as well as halogens, -OR 10 , and C, which may be substituted as needed with one or more substituents independently selected from -CN. 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 8 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from fluoro, -OH, and -CN. 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 8 is hydrogen and C 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 8 X is selected from hydrogen and C1 alkyl. In some embodiments, X 2 and X 4 If both are N, then R 8 It is selected from hydrogen.

[0160] In certain embodiments, for a compound or salt of formula (I), X 1 , X 2 , X 3 , and X4 If two of them are N, then R 7 This includes hydrogen, as well as halogens, -OR 10 , -SR 10 , -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 7 This includes hydrogen, as well as halogens, -OR 10 , and C, which may be substituted as needed with one or more substituents independently selected from -CN. 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 7 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from fluoro, -OH, and -CN. 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 7 is hydrogen and C 1~4 Selected from alkyl groups. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 7 X is selected from hydrogen and C1 alkyl. In some embodiments, X 1 , X 2 , X 3 , and X 4 If two of them are N, then R 7 It is selected from hydrogen.

[0161] In certain embodiments, for a compound or salt of formula (I), X 3 and X 1 If both are N, then R 7 This includes hydrogen, as well as halogens, -OR 10 , -SR 10 , -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 7 This includes hydrogen, as well as halogens, -OR 10 , and C, which may be substituted as needed with one or more substituents independently selected from -CN. 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 7 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from fluoro, -OH, and -CN. 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 7 is hydrogen and C 1~4 Selected from alkyl groups. In some embodiments, X 3 and X 1 If both are N, then R 7 X is selected from hydrogen and C1 alkyl. In some embodiments, X 3 and X 1 If both are N, then R 7 It is selected from hydrogen.

[0162] In certain embodiments, for a compound or salt of formula (I), X 2 and X 4 If both are N, then R 7 This includes hydrogen, as well as halogens, -OR 10 , -SR 10, -N(R 10 )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 7 This includes hydrogen, as well as halogens, -OR 10 , and C, which may be substituted as needed with one or more substituents independently selected from -CN. 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 7 C is optionally substituted with hydrogen, as well as one or more substituents independently selected from fluoro, -OH, and -CN. 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 7 is hydrogen and C 1~4 Selected from alkyl groups. In some embodiments, X 2 and X 4 If both are N, then R 7 X is selected from hydrogen and C1 alkyl. In some embodiments, X 2 and X 4 If both are N, then R 7 It is selected from hydrogen.

[0163] In some embodiments, the compound or salt of formula (I) is selected from N87, N4, N5, N13, N15, N123, N33, N111, N124, and N128.

[0164] In some embodiments, the compound or salt of formula (I) is selected from: N87, N4, N5, N13, N15, N123, N33, N111, N124, N128, N7, N18, N68, N88, N26, N103, N104, N117, N110, N37, N102, N94, N112, N81, N54, N101, N23, N136, N9, N98, N122, N31, N28, N115, N121, N74, N119, N16, N126, N47, N125, N83, N118, N10, and N62.

[0165] In some embodiments, the compound or salt of formula (I) is: N87, N4, N5, N13, N15, N123, N33, N111, N124, N128, N7, N18, N68, N88, N26, N103, N104, N117, N110, N37, N102, N94, N112, N81, N54, N101, N23, N136, N9, N98, N122, N31, N28, N115, N121, N74, N119, N16, Selected from N126, N47, N125, N83, N118, N10, N62, N41, N60, N14, N44, N108, N130, N93, N19, N77, N8, N114, N106, N3, N133, N6, N24, N127, N72, N84, N95, N132, N129, N21, N116, N55, N109, N35, N135, N59, N12, N36, N80, N99, N34, N39, and N50.

[0166] In some embodiments, the compound or salt of formula (I) is: N87, N4, N5, N13, N15, N123, N33, N111, N124, N128, N7, N18, N68, N88, N26, N103, N104, N117, N110, N37, N102, N94, N112, N81, N54, N101, N23, N136, N9, N98, N122, N31, N28, N115, N121, N74, N119, N16, N126, N47, N125, N83, N118, N10, N62, N41, N60, N Selected from 14, N44, N108, N130, N93, N19, N77, N8, N114, N106, N3, N133, N6, N24, N127, N72, N84, N95, N132, N129, N21, N116, N55, N109, N35, N135, N59, N12, N36, N80, N99, N34, N39, N50, N57, N25, N45, N2, N85, N113, N64, N78, N66, N86, N43, N30, N131, N71, N91, N38, N1, N17, N40, and N52.

[0167] In some embodiments, the compound or salt of formula (I) is: N87, N4, N5, N13, N15, N123, N33, N111, N124, N128, N7, N18, N68, N88, N26, N103, N104, N117, N110, N37, N102, N94, N112, N81, N54, N101, N23, N136, N9 , N98, N122, N31, N28, N115, N121, N74, N119, N16, N126, N47, N125, N83, N118, N10, N62, N41 , N60, N14, N44, N108, N130, N93, N19, N77, N8, N114, N106, N3, N133, N6, N24, N127, N72, N84, N95, N132, N129, N21, N116, N55, N109, N35, N135, N59, N12, N36, N80, N99, N34, N39, N50, N5 7, N25, N45, N2, N85, N113, N64, N78, N66, N86, N43, N30, N131, N71, N91, N38, N1, N17, N40, N5 Selected from 2, N11, N20, N22, N27, N29, N32, N42, N46, N48, N49, N51, N53, N56, N58, N61, N63, N65, N67, N69, N70, N73, N75, N76, N79, N82, N89, N90, N92, N96, N97, N100, N105, N107, and N120.

[0168] In some embodiments, the compound or salt of formula (I) is selected from N5, N23, N87, N124, N128, N7, N33, N117, N4, and N94.

[0169] In some embodiments, the compound or salt of formula (I) is selected from: N5, N23, N87, N124, N128, N7, N33, N117, N4, N94, N81, N88, N115, N13, and N123.

[0170] In some embodiments, the compound or salt of formula (I) is selected from: N5, N23, N87, N124, N128, N7, N33, N117, N4, N94, N81, N88, N115, N13, N123, N31, N26, N18, N74, N68, N101, N102, N41, N125, N15, N54, N9, N119, N126, N104, N37, N129, N62, N118, N95, N121, N47, N28, N111, N114, N112, and N103.

[0171] In some embodiments, the compound or salt of formula (I) is: N5, N23, N87, N124, N128, N7, N33, N117, N4, N94, N81, N88, N115, N13, N123, N31, N26, N18, N74, N68, N101, N102, N41, N125, N15, N54, N9, N119, N126, N104, N37, N129 Selected from N62, N118, N95, N121, N47, N28, N111, N114, N112, N103, N136, N122, N19, N8, N10, N21, N133, N44, N110, N77, N36, N120, N78, N2, N24, N6, N72, N116, N108, N39, N98, N127, N113, N60, and N132.

[0172] In some embodiments, the compound or salt of formula (I) is: N5, N23, N87, N124, N128, N7, N33, N117, N4, N94, N81, N88, N115, N13, N123, N31, N26, N18, N74, N68, N101, N102, N41, N125, N15, N54, N9, N119, N126, N 104, N37, N129, N62, N118, N95, N121, N47, N28, N111, N114, N112, N103, N136, N122, N19, N8 , N10, N21, N133, N44, N110, N77, N36, N120, N78, N2, N24, N6, N72, N116, N108, N39, N98, N127 , N113, N60, N132, N1, N3, N11, N12, N14, N16, N17, N20, N22, N25, N27, N29, N30, N32, N34, N3 5, N38, N40, N42, N43, N45, N46, N48, N49, N50, N51, N52, N53, N55, N56, N57, N58, N59, N61, N6 Selected from 3, N64, N65, N66, N67, N69, N70, N71, N73, N75, N76, N79, N80, N82, N83, N84, N85, N86, N89, N90, N91, N92, N93, N96, N97, N99, N100, N105, N106, N107, N109, N130, N131, and N135.

[0173] In some embodiments, for a compound or salt of formula (I), each R 1 These are independently: hydrogen; deuterium, -N3, halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R10a ,-S(O)R 10a , and -S(O)2R 10a ;C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, each of which is deuterium, -N3, halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterorings, each of which is deuterium, -N3, halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Selected from those which are replaced as needed. In some embodiments, R 2 C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, each of which is deuterium, -N3, halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterorings, each of which is deuterium, -N3, halogen, -OR 10b, -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Selected from those which are replaced as needed. In some embodiments, R 3 and R 4 Each is independent of: hydrogen, deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; as well as deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl groups; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9cIt is replaced as needed. In some embodiments, R 5 and R 6 Each is independent of: hydrogen, deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; Deuterium, -N3, Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are optionally substituted with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterorings, each of which is deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c ) Selected from those independently selected from -NO2 and -CN, and substituted as needed with one or more substituents; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed. In some embodiments, R 7 H: Hydrogen, as well as deuterium, -N3, halogen, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6Selected from alkyl. In some embodiments, R 8 H: Hydrogen; as well as deuterium, -N3, halogen, -OR 10e , -SR 10e , -N(R 10e )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are deuterium, -N3, halogen, -OR 10e , -SR 10e , -N(R 10e )2, -NO2, and -CN are selected independently and optionally substituted with one or more substituents. In some embodiments, each R 9a These are independently: deuterium, -N3, halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; as well as C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, each of which is deuterium, -N3, halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and are selected as needed to be substituted with one or more substituents independently selected from -CN. In some embodiments, each R 9b These are independently: deuterium, -N3, halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; as well as C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, each of which is deuterium, -N3, halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b)2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and are selected as needed to be substituted with one or more substituents independently selected from -CN. In some embodiments, each R 9c These are independently: deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; as well as C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, each of which is deuterium, -N3, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and are selected as needed to be substituted with one or more substituents independently selected from -CN. In some embodiments, each R 10a , R 10b , R 10c , R 10d , and R 10e Independently: Hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, each of which is deuterium, -N3, halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon rings, substituted as needed with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C 3~10 A carbon ring and a 3-membered to 10-membered heteroring, each of which is deuterium, -N3, halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, R 3 is -D. In some embodiments, R 4 is -D. In some embodiments, R 5 is -D. In some embodiments, R6 is -D. In some embodiments, R 7 is -D. In some embodiments, R 8 It is -D.

[0174] In one aspect, this disclosure relates to formula (II): [ka] The present invention provides a compound or salt thereof represented by formula (II): n is 0, 1, 2, 3, or 4; Each R 1 Independently: Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a)2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Those that are replaced as needed Selected from; R 2 teeth: Halogen, -NO2, -CN, -OR 10b , -SR10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b , and -S(O)2R 10b ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b, -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Those that are replaced as needed Selected from; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed; R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed; R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN; and Halogen, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9d It is replaced as needed; R 7 teeth: Hydrogen, as well as halogens, -OR 10e , -SR 10e , -N(R 10e )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; R 8 teeth: hydrogen; Also halogen, -OR 10f , -SR 10f , -N(R 10f)C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; R 11 teeth: Halogen, -NO2, -CN, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g , and -S(O)2R 10g ; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =S, =N(R 10g ), -CN, C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g Those that are replaced as needed Selected from; R 12 teeth, hydrogen; Halogen, CN, OH, OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h C, which is optionally substituted with one or more substituents independently selected from the group consisting of 1~6 alkyl; and C 3~6 Carbon rings and 3- to 10-membered heterocycles, each consisting of a halogen, CN, OH, or OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h Substituted as necessary with one or more substituents independently selected from the group consisting of Selected from; or R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system; Each R 9a Independently: Halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a-S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9b’ Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9c Independently: Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10c , -SR 10c , -N(R 10c)2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9d Independently: Halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d ,-C(O)N(R 10d )2, -N(R 10d )C(O)R 10d , -N(R 10d )C(O)N(R 10d )2, -OC(O)N(R 10d )2, -N(R 10d )C(O)OR 10d , -C(O)OR 10d ,-OC(O)R 10d ,-S(O)R 10d -S(O)2R 10d -NO2, =O, =S, =N(R 10d ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d ,-C(O)N(R 10d )2, -N(R 10d )C(O)R10d , -N(R 10d )C(O)N(R 10d )2, -OC(O)N(R 10d )2, -N(R 10d )C(O)OR 10d , -C(O)OR 10d ,-OC(O)R 10d ,-S(O)R 10d -S(O)2R 10d -NO2, =O, =S, =N(R 10d ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 9g Independently: Halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g)2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g ), and one or more substituents selected independently of -CN as needed. Selected from; Each R 10a , R 10b , R 10c , R 10d , R 10e , R 10f , R 10g , R 10h Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0175] In some embodiments, the compound of formula (II) is formula (II-X): [ka] It is a compound or salt of the compound n is 1, 2, 3, or 4; Each R 1 Independently: Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ; Halogen, -OR 10a , -SR 10a , -N(R 10a )2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, =O, -CN, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group, where each C 1~6 Alkyl groups consist of one or more R 9a Those that are replaced as needed Selected from; R 2 teeth: C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R10b )2, -C(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where each C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings and 3- to 10-membered heterocycles have one or more R 9b Those that are replaced as needed Selected from; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed; R 3 and R 4 Each is independent of the others: Hydrogen, halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN; and C as needed, substituted with one or more substituents independently selected from halogens, OH, -OMe, -SH, -NH2, -NO2, and -CN. 1~6 Alkyl Selected from; or; R 5 and R 6 Each is independent of the others: Hydrogen, halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN; and C as needed, substituted with one or more substituents independently selected from halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN. 1~6 Alkyl Selected from; R 7 teeth: Hydrogen, as well as C, optionally substituted with one or more substituents independently selected from halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN. 1~6 Alkyl Selected from; R 8 teeth: Hydrogen, as well as C, optionally substituted with one or more substituents independently selected from halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN. 1~6 Alkyl Selected from; R 11 teeth: Halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN; and C as needed, substituted with one or more substituents independently selected from halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN. 1~6 Alkyl Selected from; R 12 teeth, hydrogen; C is optionally substituted with one or more substituents independently selected from the group consisting of halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN. 1~6 alkyl; and C 3~6 Carbon rings and 3- to 10-membered heterocycles, each optionally substituted with one or more substituents independently selected from the group consisting of halogens, -OH, -OMe, -SH, -NH2, -NO2, and -CN. Selected from; or R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system; Each R 9a These are independently halogen, -OR 10a , -CN, and C 1~6 Selected from alkyl groups; Each R 9b These are independently halogen, -OR 10b , -CN, and C 1~6 Selected from alkyl groups; Each R 9b’ These are independently halogen, -OR 10b , -CN, and C 1~6 Selected from alkyl groups; Each R 10a , R 10b Hydrogen and C are independent of each other. 1~6 Alkyl, C 3~10 They are selected from carbon rings and 3- to 10-membered heterocycles.

[0176] In some embodiments, the compound of formula II is formula (II-Y): [ka] It is a compound or salt of the compound n is either 1 or 2; Each R 1 Independently: Halogen, -CN, -OR 10a , -SR 10a , -N(R 10a )2; as well as halogen, -OR 10a , -SR 10a , -N(R 10a )2, =O, and -CN, as needed, substituted with one or more substituents independently selected from C 1~6 Alkyl Selected from; R 2 teeth: C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , =O, -CN, C 1~6 Alkyl, C 2~6 Alkinyl, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where each C 1~6 Alkyl, C 2~6 Alkinyl, C3~10 Carbon rings and 3- to 10-membered heterocycles have one or more R 9b Those that are replaced as needed Selected from; R 3 and R 4 Each is independent of the others: Hydrogen, halogens, -OH, -OMe- and -CN; and C as needed, substituted with one or more substituents independently selected from halogens, OH, -OMe, and -CN. 1~3 Alkyl Selected from; R 5 and R 6 Each is independent of the others: Hydrogen, halogens, -OH, -OMe- and -CN; and C as needed, substituted with one or more substituents independently selected from halogens, -OH, -OMe, and -CN 1~3 Alkyl Selected from; R 7 teeth: Hydrogen, and C as needed, substituted with one or more substituents independently selected from halogens, -OH, -OMe, and -CN. 1~3 Alkyl Selected from; R 8 teeth: Hydrogen, and C as needed, substituted with one or more substituents independently selected from halogens, -OH, -OMe, and -CN. 1~3 Alkyl Selected from; R 11 teeth: C as needed, substituted with one or more substituents independently selected from halogens, -OH, -OMe, and -CN 1~3 Alkyl Selected from; R 12 is hydrogen, C 1~3 Alkyl, C 3~6Selected from carbocyclic and 3- to 10-membered groups; or R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system; Each R 9a These are independently halogen, -OH, -OMe, -CN, and C 1~3 Selected from alkyl groups; Each R 9b These are independently halogen, -OH, -OMe, -CN, and C 1~3 Selected from alkyl groups; Each R 9b’ These are independently halogen, -OH, -OMe, -CN, and C 1~3 Selected from alkyl groups; Each R 10a , R 10b Hydrogen and C are independent of each other. 1~6 Alkyl, C 6~10 They are selected from carboelectric rings and 5- to 10-membered heterocycles.

[0177] In some embodiments, for a compound or salt of formula (II), n is 0, 1, 2, 3, or 4. In some embodiments, n is 0, 1, 2, or 3. In some embodiments, n is 0, 1, 2, or 4. In some embodiments, n is 0, 1, 3, or 4. In some embodiments, n is 0, 2, 3, or 4. In some embodiments, n is 1, 2, 3, or 4. In some embodiments, n is 0, 1, or 2. In some embodiments, n is 0, 1, or 3. In some embodiments, n is 0, 1, or 4. In some embodiments, n is 0, 2, or 3. In some embodiments, n is 0, 2, or 4. In some embodiments, n is 0, 3, or 4. In some embodiments, n is 1, 2, or 3. In some embodiments, n is 1, 2, or 4. In some embodiments, n is 0 or 1. In some embodiments, n is 0 or 2. In some embodiments, n is 0 or 3. In some embodiments, n is 0 or 4. In some embodiments, n is 1 or 2. In some embodiments, n is 1 or 3. In some embodiments, n is 1 or 4. In some embodiments, n is 2 or 3. In some embodiments, n is 2 or 4. In some embodiments, n is 3 or 4. In some embodiments, n is 0. In some embodiments, n is 1. In some embodiments, n is 2. In some embodiments, n is 3. In some embodiments, n is 4. In some embodiments, n is 0. In some embodiments, n is 1 or 2. In some embodiments, n is 1. In some embodiments, n is 2. In some embodiments, n is 0 or 1. In some embodiments, n is 0 or 2.

[0178] In some embodiments, for a compound or salt of formula (II), each R 1 Independently: Halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a , and -S(O)2R 10a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9aThose which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9a Selected from those that have been replaced as needed;

[0179] In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a , and -OC(O)R 10a ;C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl, and C 2~6 Each alkenil contains one or more R 9a It is then selected from the options that have been replaced as needed.

[0180] In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R10a , -C(O)OR 10a , and -OC(O)R 10a ;C 1~6 Alkyl and C 2~6 Alkenyls, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -C(O)OR 10a ,-OC(O)R 10a -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl, and C 2~6 Each alkenil contains one or more R 9a Selected from those which are replaced as needed. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, and -C(O)R 10a;C 1~6 Alkyl and C 2~6 Alkenyls, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl, and C 2~6 Each alkenil contains one or more R 9a Selected from those which are replaced as needed. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, and -C(O)R 10a ;C 1~6 Alkyl and C 2~6 Alkenyls, each of which is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Those which are replaced as necessary; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, and -C(O)R 10a ; and halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Selected from those which are replaced as needed. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, and -C(O)R 10a ; and halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9a Selected from those which are replaced as needed. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a)2, and -C(O)R 10a ; and halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~6 Selected from alkyl groups. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , -N(R 10a )2, and -C(O)R 10a ; and C 1~6 Selected from alkyl groups. In some embodiments, each R 1 These are independently: halogen, -NO2, -CN, -OR 10a , -SR 10a , and -N(R 10a ) Selected from 2. In some embodiments, each R 1 R is independently selected from halogen and -CN. In some embodiments, each R 1 R is independently selected from fluoro, bromo, and -CN. In some embodiments, each R 1 R is independently selected from fluoro and CN. In some embodiments, each R 1 R is independently selected from fluoro and bromo. In some embodiments, each R 1 These are independently selected from bromo and CN. Several embodiments are available for each R 1 R is independently selected from fluoro. In some embodiments, each R 1 R is independently selected from bromo. In some embodiments, each R 1 R is independently selected from CN. In some embodiments, each R 1 These are independently: halogen, -CN, -OR 10a , and C 1~6 Selected from alkyl groups. In some embodiments, each R 1 These are independently: halogen, -CN, -OR10a , and C 1~6 Selected from alkyl groups. In some embodiments, each R 1 R is independently selected from -F, -Br, -Cl, -CN, -OH, and -CH3. In some embodiments, each R 1 The following are independently selected from -F, -Br, -CN, -OH, and -CH3.

[0181] In some embodiments, n is 2, and each R 1 These are independently selected from -F, -Cl, and -CN. In some embodiments, n is 2, and each R 1 n is independently selected from -F and -CN. In some embodiments, n is 2, and each R 1 R is independently selected from -F. In some embodiments, R 3 and R 4 R is ortho to the carbon having 1 is -F. In some embodiments, R 3 and R 4 R is meta to carbon that has 1 is -F. In some embodiments, R 3 and R 4 R is para to the carbon that has 1 is -F. In some embodiments, R 3 and R 4 R is ortho to the carbon having 1 is -F, and R 3 and R 4 R is meta to carbon that has 1 is -F. In some embodiments, n is 2, and R 3 and R 4 R is ortho to the carbon having 1 is -F, and R 3 and R 4 R is meta to carbon that has 1 is -F.

[0182] In some embodiments, the compound of formula (II) is of formula (II-A) [ka] Selected from.

[0183] In some embodiments, the compound of formula (II) is of formula (II-B) [ka] Selected from, where each Y is -(CR 9b )- and N are selected.

[0184] In some embodiments, the compound of formula (II) is of formula (II-C) [ka] Selected from.

[0185] In some embodiments, the compound of formula (II) is (II-D) [ka] Selected from, where each Y is -(CR 9b )- and N are selected.

[0186] In some embodiments, the compound of formula (II) is of formula (II-E) [ka] Selected from.

[0187] In some embodiments, the compound of formula (II) is (II-F) [ka] Selected from, where each Y is -(CR 9b )- and N are selected.

[0188] In some embodiments, for a compound or salt of formula (II), R 2 teeth: Halogen, -NO2, -CN, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b , and -S(O)2R 10b ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9bThose which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Those that are replaced as needed Selected from; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed.

[0189] In some embodiments, R 2 R 11 and R 12 Along with one or more R 9b’ A bridged 5- to 20-membered heterogeneous ring or bridged C, as substituted as necessary.5~20 It forms a carbon ring. In some embodiments, R 2 R 11 and R 12 Along with one or more R 9b’ A bridged 5- to 18-membered heterogeneous ring or bridged C, substituted as needed. 5~18 It forms a carbon ring. In some embodiments, R 2 R 11 and R 12 Along with one or more R 9b’ A bridged 5- to 15-membered heterogeneous ring or bridged C, substituted as needed. 5~15 It forms a carbon ring. In some embodiments, R 2 R 11 and R 12 Along with one or more R 9b’ A bridged 5- to 12-membered heterogeneous ring or bridged C, substituted as needed. 5~12 It forms a carbon ring. In some embodiments, R 2 R 11 and R 12 Along with one or more R 9b’ A bridged 5- to 10-membered heterogeneous ring or bridged C, as substituted as necessary. 5~10 It forms a carbon ring.

[0190] In some embodiments, R 2 H: Halogen, -NO2, -CN, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b , and -OC(O)R 10b ;C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkynyl, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Each alkynyl has one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed.

[0191] In some embodiments, for a compound or salt of formula (II), R 2 H: Halogen, -NO2, -CN, -OR10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b , and -OC(O)R 10b ;C 1~6 Alkyl and C 2~6 Alkenyls, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -C(O)OR 10b ,-OC(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 H: Halogen, -NO2, -CN, -OR 10b , -SR 10b , and -N(R 10b )2;C 1~6 Alkyl and C 2~6 Alkenyls, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9b Those which are replaced as necessary; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’It is replaced as needed. In some embodiments, R 2 H: Halogen, -NO2, -CN, -OR 10b , -SR 10b , and -N(R 10b )2; Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN. 1~6 Alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 H: Halogen, -NO2, -CN, -OR 10b , -SR 10b , and -N(R 10b )2; 1 or more - OR 10b C replaced as needed 1~6 Alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R10b -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed.

[0192] In some embodiments, R 2 H: Halogen, -NO2, -CN, -OR 10b , -SR 10b , and -N(R 10b )2;C 1~6 Alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R2 ha:C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN, C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed.

[0193] In some embodiments, R 2 ha:C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b ,-CN,C 1~6 Alkyl, and C 2~6 It is optionally substituted with one or more substituents independently selected from the alkenyl, where C 1~6 Alkyl and C 2~6 Each alkenil contains one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 ha:C 3~10Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , -CN, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group, where C 1~6 Alkyl groups consist of one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 ha:C 3~10 A carbocyclic ring and a 3- to 10-membered heterocycle, each of which is fluoro, bromo, or -OR. 10b , -CN, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group, where C 1~6 Alkyl groups consist of one or more R 9b Selected from those that have been replaced as needed; or R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 ha:C 3~10 Selected from carbocyclic and 3- to 10-membered heterocycles, each of which is fluoro, bromo, -OMe, -CN, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group, where C 1~6 Alkyl groups consist of one or more R 9b It is replaced as needed. In some embodiments, R 2 ha:C 3~10Selected from carbocyclic and 3- to 10-membered heterocycles, each of which is fluoro, bromo, -OMe, -CN, and C 1~6 It is optionally substituted with one or more substituents independently selected from the alkyl group, where C 1~6 The alkyl group is optionally substituted with one or more fluoro groups. In some embodiments, R 2 ha:C 3~10 Selected from carbocyclic and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from fluoro, bromo, -OMe, -CN, and C1 alkyl groups, where the C1 alkyl group is optionally substituted with one or more fluoro groups.

[0194] In some embodiments, R 2 The compounds are selected from pyrazinyl (e.g., 2-pyrazinyl, 3-pyrazinyl), pyridazinyl (e.g., 3-, 4-, 5-, or 6-pyridazine), phenyl, pyridyl (e.g., 2-, 3-, or 4-pyridyl), and pyrimidyl (e.g., 2-, 4-, 5-, or 6-pyrimidyl), where each pyrazinyl, pyridyl, phenyl, pyridyl, and pyrimidyl is fluoro, bromo, - The OMe, -CN, and C1 alkyl groups are optionally substituted with one or more substituents independently selected from these groups, where each C1 alkyl group is optionally substituted with one or more fluoro substituents. In some embodiments, R 2 R is selected from phenyl, pyridyl, and pyrimidyl, where each phenyl, pyridyl, and pyrimidyl is optionally substituted with one or more substituents independently selected from fluoro, bromo, -OMe, -CN, and C1 alkyl, where each C1 alkyl is optionally substituted with one or more fluoro substituents. In some embodiments, R 2R is selected from phenyl, 2-pyridyl, 2-pyrimidyl, and 6-pyrimidyl, where each phenyl, 2-pyridyl, 2-pyrimidyl, and 6-pyrimidyl is optionally substituted with one or more substituents independently selected from fluoro, bromo, -OMe, -CN, and C1 alkyl, where each C1 alkyl is optionally substituted with one or more fluoro substituents. In some embodiments, R 2 ha:C 3~10 Selected from carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10b , =O, -CN, C 1~6 Alkyl, C 2~6 Alkinyl, C 3~10 It is optionally substituted with one or more substituents independently selected from the carbon ring and the 3-membered to 10-membered heterocycle. In some embodiments, R 2 ha:C 3~10 Selected from carbocyclic and 3- to 10-membered heterocycles, each of which is -F, -Cl, -Br, -CN, -OH, -OCH3, -CH3, -CF3, -C(O)NH2, [ka] And, as needed, it is substituted with one or more substituents selected independently of -CCH.

[0195] In some embodiments, R 2 teeth, [ka] [ka] Selected from.

[0196] In some embodiments, R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 is R 11 Together with, 3-membered to 10-membered complex rings or C 3~10 They form a carbon ring, and this 3- to 10-membered heterocycle or C 3~10 The carbon ring is optionally substituted with one or more fluoro or CN atoms. In some embodiments, R 2 is R 11 Together with C 3~10 They form a carbocyclic or a 3- to 10-membered heterocycle selected from dihydrobenzofuran and indene, each of which is optionally substituted with one or more substituents independently selected from fluoro and CN.

[0197] In some embodiments, R 11 R 2 teeth, [ka] [ka] Selected from. In some embodiments, R 12 H is H, and R 11 R 2 teeth, [ka] Selected from. In some embodiments, R 12 H is H, and R 11 R 2 teeth, [ka] Selected from.

[0198] In some embodiments, R 2 and R 11 This refers to a 3-member to 10-membered complex ring or C 3~10It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9b’ It is replaced as needed. In some embodiments, R 2 and R 11 This refers to a 3-member to 10-membered complex ring or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 The carbon ring is optionally substituted with one or more substituents selected from halogens and CN. In some embodiments, R 2 and R 11 This refers to a 3-member to 10-membered complex ring or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 The carbon ring is optionally substituted with one or more substituents selected from fluorine and CN. In some embodiments, R 2 and R 11 This refers to a 3-member to 10-membered complex ring or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 The carbon ring is optionally substituted with one or more substituents selected from halogens. In some embodiments, R 2 and R 11 This refers to a 3-member to 10-membered complex ring or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 The carbon ring is optionally substituted with one or more substituents selected from fluorine. In some embodiments, R 2 and R 11 This refers to a 3-member to 10-membered complex ring or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 The carbocyclic ring is optionally substituted with one or more substituents selected from CN.

[0199] In some embodiments, R 2 ha:C 3~10Selected from carbocyclic and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from fluoro, bromo, -OMe, -CN, and C1 alkyl groups, where the C1 alkyl group is optionally substituted with one or more fluoro groups. In some embodiments, R 2 ha:C 3~10 Selected from carbocyclic and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from fluoro, bromo, -CN, and C1 alkyl groups. In some embodiments, R 2 ha:C 3~10 They are selected from carbocyclic and 3- to 10-membered heterocycles, each of which is optionally substituted with one or more substituents independently selected from fluoro, bromo, -CN, and C1 alkyl groups.

[0200] In some embodiments, R 2 C1 alkyl is optionally substituted with one or more substituents independently selected from fluoro, bromo, -CN, and C1 alkyl groups. 3~10 It is a carbon ring. In some embodiments, R 2 C1 alkyl is optionally substituted with one or more substituents independently selected from fluoro, -CN, and C1 alkyl groups. 3~10 It is a carbon ring. In some embodiments, R 2 C is optionally substituted with one or more substituents independently selected from fluoro and -CN. 3~10 It is a carbon ring. In some embodiments, R 2 C is optionally substituted with one or more substituents selected independently of fluoro. 3~10 It is a carbon ring. In some embodiments, R 2 C is optionally substituted with one or more substituents independently selected from chloro. 3~10 It is a carbon ring.

[0201] In some embodiments, for a compound or salt of formula (II), R 3 and R 4 Each is independent of the others: Hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; and Halogen, -OR 10c , -SR 10c , -N(R 10c )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl groups; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed.

[0202] In some embodiments, R 3 and R 4 Each is independently: hydrogen; and C is optionally substituted with one or more substituents independently selected from halogens. 1~6 Selected from alkyl groups; or R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed. In some embodiments, R 3 and R 4 Each is independently: hydrogen; and C is optionally substituted with one or more substituents independently selected from halogens. 1~6 Selected from alkyl groups.

[0203] In some embodiments, R 3 and R 4Each is independently selected from C1 alkyl groups substituted as needed with one or more substituents independently selected from hydrogen and fluoro.

[0204] In some embodiments, R 3 and R 4 Each is independently selected from: hydrogen; and C1 alkyl. In some embodiments, R 3 and R 4 Each is independently selected from hydrogen. In some embodiments, R 3 a: Selected from hydrogen. In some embodiments, R 4 a: Selected from hydrogen. In some embodiments, R 3 is -H, and R 4 is -OH. In some embodiments, R 3 is -OH, and R 4 is -H. In some embodiments, R 3 It is -OH.

[0205] In some embodiments, R 3 is R 4 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, and this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9c It is replaced as needed. In some embodiments, R 3 is R 4 Together with C 3~10 Forming a carbon ring, this C 3~10 A carbon ring contains one or more R 9c It is replaced as needed. In some embodiments, R 3 is R 4 Together with C 3~10 It forms a carbon ring. In some embodiments, R 3 is R 4 Along with C selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl 3~10It forms a carbon ring. In some embodiments, R 3 is R 4 Together, [ka] Forms a ring selected from.

[0206] In some embodiments, for a compound or salt of formula (II), R 5 and R 6 Each is independent of the others: Hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN; and Halogen, -OR 10d , -SR 10d , -N(R 10d )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Alkyl Selected from; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9d It is replaced as needed.

[0207] In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN; and C 1~6 Selected from alkyl groups; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9dIt is replaced as needed. In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN; and C 1~6 Selected from alkyl groups; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring. In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN; and C 1~6 Selected from alkyl. In some embodiments, R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10d , -SR 10d , -N(R 10d )2, -NO2, and -CN are selected. In some embodiments, R 5 and R 6 is hydrogen. In some embodiments, R 5 is hydrogen. In some embodiments, R 6 is hydrogen. In some embodiments, R 5 and R 6 Each is independently selected from hydrogen; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10 It forms a carbon ring, where this 3-membered to 10-membered heterocycle or C 3~10 A carbon ring contains one or more R 9d It is replaced as needed in R. 5 and R 6 Each is independently selected from hydrogen; or R 5 is R 6 Together with, 3-membered to 10-membered complex rings or C 3~10A compound or salt according to any one of claims 92 to 137 or claim 141, which forms a carbon ring. In some embodiments, R 5 and R 6 Each is independently selected from: hydrogen and -CH3, or R 5 and R 6 Together with it, it forms a cyclopropyl group.

[0208] In some embodiments, the compound or salt of formula (II) is formula (II-Q): [ka] It is a compound or salt of formula (II-Q). In some embodiments, the compound or salt of formula (II-Q) is an activator of skeletal myosin. In some embodiments, the compound or salt of formula (II-Q) is used to treat obesity or to induce weight loss. In some embodiments, for the compound or salt of formula (IQ), R 5 and R 6 Each is independent of: hydrogen, halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN; halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~10 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are optionally substituted with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR 10c , -N(R 10c)2, -NO2, and -CN are selected independently and optionally substituted with one or more substituents. In some embodiments, R 5 is -H, and R 6 is: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~10 It is an alkyl group, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN, which are optionally substituted with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are selected independently and optionally substituted with one or more substituents. In some embodiments, R 5 is -H, and R 6 is: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~10 Selected from alkyl groups, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R6 is: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Carbon rings and C rings optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. 1~6 Selected from alkyl groups, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R 6 is halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10 Branched (e.g., non-linear, e.g., primary, secondary, or tertiary) carbon rings, optionally substituted with one or more substituents independently selected from 3- to 10-membered heterocycles. 1~6 It is alkyl, where each C 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R 6 is halogen, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, -CN, C 3~10A methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety, where each C is optionally substituted with one or more substituents independently selected from a carbon ring and a 3- to 10-membered heterocycle. 3~10 Carbon rings and 3- to 10-membered heterocycles are halogens, -OR 10c , -SR 10c , -N(R 10c )2, -NO2, and -CN are optionally substituted with one or more substituents independently selected from these. In some embodiments, R 5 is -H, and R 6 C 3~10 A methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety, where each C is optionally substituted with one or more substituents independently selected from the carbon ring. 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from halogens and -CN. In some embodiments, R 5 is -H, and R 6 C 3~10 The carbon ring is optionally substituted with one or more substituents independently selected from the carbon ring, and is a methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl moiety. In some embodiments, R 5 is -H, and R 6The moiety is n-propyl, i-propyl, n-butyl, s-butyl, i-butyl, t-butyl, n-pentyl, tert-pentyl, neopentyl, isopentyl, sec-pentyl, 3-pentyl, sec-isopentyl, or 2-methylbutyl.

[0209] In some embodiments, for a compound or salt of formula (II), R 7 H: Hydrogen, as well as halogens, -OR 10e , -SR 10e , -N(R 10e )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl. In some embodiments, R 7 H: Hydrogen, and C 1~3 Selected from alkyl. In some embodiments, R 7 : Selected from hydrogen.

[0210] In some embodiments, for a compound or salt of formula (II), R 8 H: Hydrogen, as well as halogens, -OR 10f , -SR 10f , -N(R 10f )C substituted as needed with one or more substituents independently selected from -NO2 and -CN 1~6 Selected from alkyl. In some embodiments, R 8 is: C, which is optionally substituted with hydrogen, as well as halogens and one or more substituents independently selected from -CN. 1~6 Selected from alkyl. In some embodiments, R 8 is: hydrogen, and C optionally substituted with one or more substituents independently selected from fluoro and -CN. 1~6 Selected from alkyl. In some embodiments, R 8 is: Hydrogen and C 1~3 Selected from alkyl groups. In some embodiments, for a compound or salt of formula (II), R 8a: Selected from hydrogen and C1 alkyl. In some embodiments, R 8 : Selected from hydrogen.

[0211] In some embodiments, for a compound or salt of formula (II), R 11 teeth: Halogen, -NO2, -CN, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g , and -S(O)2R 10g ; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =S, =N(R 10g ), -CN, C 3~10It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g Those that are replaced as needed Selected from.

[0212] In some embodiments, R 11 H: Halogen, -NO2, -CN, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g , and -OC(O)R 10g ; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g -NO2, =O, -CN, and C 3~10 It is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g Selected from those which are replaced as needed. In some embodiments, R 11 H: Halogen, -NO2, -CN, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R10g )C(O)R 10g , -C(O)OR 10g , and -OC(O)R 10g ; and halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g -NO2, =O, -CN, and C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g Selected from those which are replaced as needed. In some embodiments, R 11 H: Halogen, -NO2, -CN, -OR 10g , -SR 10g , and -N(R 10g )2; as well as halogen, -OR 10g , -SR 10g , -N(R 10g )2, -NO2, =O, -CN, and C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 It is alkyl, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g Selected from those which are replaced as needed. In some embodiments, R 11 H: Halogen, -NO2, -CN, -OR 10g , -SR 10g , and -N(R 10g )2; as well as halogen, -OR 10g , -SR 10g , -N(R 10g)C as needed, substituted with one or more substituents independently selected from -NO2, -O, and -CN 1~6 Selected from alkyl. In some embodiments, R 11 is: halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g ), -CN, C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 Selected from alkyl, here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g It is replaced as needed. In some embodiments, R 11 is: halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -C(O)OR 10g ,-OC(O)R 10g -NO2, =O, -CN, and C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 Selected from alkyl, here this C 3~10Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g It is replaced as needed. In some embodiments, R 11 is: halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g -NO2, =O, -CN, and C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 Selected from alkyl, here this C 3~10 Carbon rings and 3- to 10-membered heterocycles each contain one or more R 9g It is replaced as needed. In some embodiments, R 11 is: halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g -NO2, =O, -CN, and C 3~10 C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. 1~6 Selected from alkyl. In some embodiments, R 11 is: halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~6 Selected from alkyl. In some embodiments, R 11 is: halogen and -OR 10g C as needed, substituted with one or more substituents independently selected from 1~3 Selected from alkyl. In some embodiments, R 11 is: 1 or more - OR 10g C replaced as needed 1~3 Selected from alkyl. In some embodiments, R 11is: C substituted as needed with one or more -OH groups 1~3 Selected from alkyl groups.

[0213] In some embodiments, for a compound or salt of formula (II), R 12 teeth, hydrogen; Halogen, CN, OH, OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h C, which is optionally substituted with one or more substituents independently selected from the group consisting of 1~6 alkyl; and C 3~6 Carbon rings and 3- to 10-membered heterocycles, each consisting of a halogen, CN, OH, or OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h Substituted as necessary with one or more substituents independently selected from the group consisting of Selected from; or R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system.

[0214] In some embodiments, R 12 Hydrogen; halogens, CN, OH, OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h C, which is optionally substituted with one or more substituents independently selected from the group consisting of 1~6 Alkyl; and C 3~6 Carbon rings and 3- to 10-membered heterocycles, each consisting of a halogen, CN, OH, or OR 10h , N(R 10h)2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h Selected from the group consisting of, independently of, one or more substituents as needed, which are substituted as required; or R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system. In some embodiments, R 12 Hydrogen; halogens, CN, OH, OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h C, which is optionally substituted with one or more substituents independently selected from the group consisting of 1~6 Alkyl; and C 3~6 Carbon rings and 3- to 10-membered heterocycles, each consisting of a halogen, CN, OH, or OR 10h , N(R 10h )2, NO2, C(O)R 10h , SR 10h , and S(O)R 10h Selected from the group consisting of, and optionally substituted with one or more substituents independently selected from the group consisting of, 12 hydrogen; as well as halogens, CN, OH, OR 10h , N(R 10h )2, NO2, C(O)R 10h , and SR 10h C, which is optionally substituted with one or more substituents independently selected from the group consisting of 1~6 Selected from alkyl. In some embodiments, R 12 is hydrogen; and C 1~6 Selected from alkyl groups.

[0215] In some embodiments, R 12 is hydrogen. In some embodiments, R 12 is methyl. In some embodiments, R 12is ethyl. In some embodiments, R 12 , R 11 , and R 2 Together, C5~C 10 It forms a bridged ring system. In some embodiments, R 12 , R 11 , and R 2 Together, C5-C selected from [1.1.1]bicyclopentane 10 It forms a bridged ring system.

[0216] In some embodiments, for a compound or salt of formula (II), each R 9a These are independently: halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a , -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and -CN; as well as C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a ,-C(O)N(R 10a )2, -N(R 10a )C(O)R 10a , -N(R 10a )C(O)N(R 10a )2, -OC(O)N(R 10a )2, -N(R 10a )C(O)OR 10a, -C(O)OR 10a ,-OC(O)R 10a ,-S(O)R 10a -S(O)2R 10a -NO2, =O, =S, =N(R 10a ), and are selected as needed to be substituted with one or more substituents independently selected from -CN. In some embodiments, each R 9a These are independently: halogen, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a -NO2, =O, -CN; and halogens, -OR 10a , -SR 10a , -N(R 10a )2, -C(O)R 10a C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9a C is independently: halogen, -NO2, =O, -CN; and C is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9a C is independently: halogen and -CN; and C is optionally substituted with one or more substituents independently selected from halogen and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9a R is independently selected from fluoro and -CN; as well as C1 alkyl groups optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments, each R 9a R is independently selected from fluoro and -CN, as well as C1 alkyl. In some embodiments, each R 9a R is independently selected from :fluoro and -CN. In some embodiments, each R 9aR is independently selected from fluoro. In some embodiments, each R 9a It is selected independently from :-CN.

[0217] In some embodiments, for a compound or salt of formula (II), each R 9b Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b), and one or more substituents selected independently of -CN as needed. Selected from.

[0218] In some embodiments, each R 9b These are independently: halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN; and halogens, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9b C is independently: halogen, -NO2, =O, -CN; and C is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9b R is independently selected from halogens. In some embodiments, each R 9b R is independently selected from fluoro. In some embodiments, each R 9b C is independently: halogen and -CN; and C is optionally substituted with one or more substituents independently selected from halogen and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9b R is independently selected from fluoro and -CN; as well as C1 alkyl groups optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments, each R 9b R is independently selected from fluoro and -CN, as well as C1 alkyl. In some embodiments, each R 9b R is independently selected from :fluoro and -CN. In some embodiments, each R9b R is independently selected from fluoro. In some embodiments, each R 9b R is independently selected from :-CN. In some embodiments, each R 9b These are independently: -F, -Cl, -Br, -CN, -OH, -OCH3, -CH3, -CF3, -C(O)NH2, [ka] and -CCH are selected. In some embodiments, each R 9b The following are independently selected from: -F, -Cl, -Br, -CN, -OH, -OCH3, -CH3, and -CF3.

[0219] In some embodiments, for a compound or salt of formula (II), each R 9b’ Independently: Halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b )C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b ,-C(O)N(R 10b )2, -N(R 10b)C(O)R 10b , -N(R 10b )C(O)N(R 10b )2, -OC(O)N(R 10b )2, -N(R 10b )C(O)OR 10b , -C(O)OR 10b ,-OC(O)R 10b ,-S(O)R 10b -S(O)2R 10b -NO2, =O, =S, =N(R 10b ), and one or more substituents selected independently of -CN as needed. Selected from.

[0220] In some embodiments, each R 9b’ These are independently: halogen, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b -NO2, =O, -CN; and halogens, -OR 10b , -SR 10b , -N(R 10b )2, -C(O)R 10b C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9b’ C is independently: halogen, -NO2, =O, -CN; and C is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9b’ R is independently selected from halogen and CN. In some embodiments, each R 9b’ R is independently selected from fluoro and CN. In some embodiments, each R 9b’ R is independently selected from fluoro. In some embodiments, each R 9b’ R is independently selected from fluoro, bromo, and CN. In some embodiments, each R9b’ C is independently: halogen and -CN; and C is optionally substituted with one or more substituents independently selected from halogen and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9b’ R is independently selected from fluoro and -CN; as well as C1 alkyl groups optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments, each R 9b’ R is independently selected from fluoro and -CN, as well as C1 alkyl. In some embodiments, each R 9b’ R is independently selected from :fluoro and -CN. In some embodiments, each R 9b’ R is independently selected from fluoro. In some embodiments, each R 9b’ It is selected independently from :-CN.

[0221] In some embodiments, for a compound or salt of formula (II), each R 9c Independently: Halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR10c , -SR 10c , -N(R 10c )2, -C(O)R 10c ,-C(O)N(R 10c )2, -N(R 10c )C(O)R 10c , -N(R 10c )C(O)N(R 10c )2, -OC(O)N(R 10c )2, -N(R 10c )C(O)OR 10c , -C(O)OR 10c ,-OC(O)R 10c ,-S(O)R 10c -S(O)2R 10c -NO2, =O, =S, =N(R 10c ), and one or more substituents selected independently of -CN as needed. Selected from.

[0222] In some embodiments, each R 9c These are independently: halogen, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c -NO2, =O, -CN; and halogens, -OR 10c , -SR 10c , -N(R 10c )2, -C(O)R 10c C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9c C is independently: halogen, -NO2, =O, -CN; and C is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9c C is independently: halogen and -CN; and C is optionally substituted with one or more substituents independently selected from halogen and -CN. 1~3Selected from alkyl groups. In some embodiments, each R 9c R is independently selected from fluoro and -CN; as well as C1 alkyl groups optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments, each R 9c R is independently selected from fluoro and -CN, as well as C1 alkyl. In some embodiments, each R 9c R is independently selected from :fluoro and -CN. In some embodiments, each R 9c R is independently selected from fluoro. In some embodiments, each R 9c It is selected independently from :-CN.

[0223] In some embodiments, for a compound or salt of formula (II), each R 9d Independently: Halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d ,-C(O)N(R 10d )2, -N(R 10d )C(O)R 10d , -N(R 10d )C(O)N(R 10d )2, -OC(O)N(R 10d )2, -N(R 10d )C(O)OR 10d , -C(O)OR 10d ,-OC(O)R 10d ,-S(O)R 10d -S(O)2R 10d -NO2, =O, =S, =N(R 10d ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d ,-C(O)N(R 10d)2, -N(R 10d )C(O)R 10d , -N(R 10d )C(O)N(R 10d )2, -OC(O)N(R 10d )2, -N(R 10d )C(O)OR 10d , -C(O)OR 10d ,-OC(O)R 10d ,-S(O)R 10d -S(O)2R 10d -NO2, =O, =S, =N(R 10d ), and one or more substituents selected independently of -CN as needed. Selected from;

[0224] In some embodiments, each R 9d These are independently: halogen, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d -NO2, =O, -CN; and halogens, -OR 10d , -SR 10d , -N(R 10d )2, -C(O)R 10d C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9d C is independently: halogen, -NO2, =O, -CN; and C is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9d C is independently: halogen and -CN; and C is optionally substituted with one or more substituents independently selected from halogen and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9dR is independently selected from fluoro and -CN; as well as C1 alkyl groups optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments, each R 9d R is independently selected from fluoro and -CN, as well as C1 alkyl. In some embodiments, each R 9d R is independently selected from :fluoro and -CN. In some embodiments, each R 9d R is independently selected from fluoro. In some embodiments, each R 9d It is selected independently from :-CN.

[0225] In some embodiments, for a compound or salt of formula (II), each R 9g Independently: Halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R 10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alkynnyl, where each of these is a halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g ,-C(O)N(R 10g )2, -N(R 10g )C(O)R 10g , -N(R10g )C(O)N(R 10g )2, -OC(O)N(R 10g )2, -N(R 10g )C(O)OR 10g , -C(O)OR 10g ,-OC(O)R 10g ,-S(O)R 10g -S(O)2R 10g -NO2, =O, =S, =N(R 10g ), and one or more substituents selected independently of -CN as needed. Selected from.

[0226] In some embodiments, each R 9g These are independently: halogen, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g -NO2, =O, -CN; and halogens, -OR 10g , -SR 10g , -N(R 10g )2, -C(O)R 10g C as needed, substituted with one or more substituents independently selected from -NO2, =O, and -CN 1~3 Selected from alkyl groups. In some embodiments, each R 9g C is independently: halogen, -NO2, =O, -CN; and C is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9g C is independently: halogen and -CN; and C is optionally substituted with one or more substituents independently selected from halogen and -CN. 1~3 Selected from alkyl groups. In some embodiments, each R 9g R is independently selected from fluoro and -CN; as well as C1 alkyl groups optionally substituted with one or more substituents independently selected from fluoro and -CN. In some embodiments, each R9g R is independently selected from fluoro and -CN, as well as C1 alkyl. In some embodiments, each R 9g R is independently selected from :fluoro and -CN. In some embodiments, each R 9g R is independently selected from fluoro. In some embodiments, each R 9b It is selected independently from :-CN.

[0227] In some embodiments, for a compound or salt of formula (II), each R 10a Independently: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 A carbon ring, or a 3-membered to 10-membered heterocycle, substituted as necessary with one or more substituents independently selected from these; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from.

[0228] In some embodiments, each R10a These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 C is a carbon ring, or a 3-membered to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from these carbon rings. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10a These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 They are selected from carbon rings and 3- to 10-membered heterocycles.

[0229] In some embodiments, each R 10a These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Selected from alkyl groups. In some embodiments, each R 10a Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10a It is independently selected from hydrogen.

[0230] In some embodiments, for a compound or salt of formula (II), each R 10bEach R is independently selected from the following: 10b Independently: Hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon rings, substituted as needed with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, each R 10b is hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon rings, substituted as needed with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C 3~10Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, each R 10b These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 C is a carbon ring, or a 3-membered to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from these carbon rings. 1~6 Alkyl; and C 3~10 They are selected from carbon rings and 3- to 10-membered heterocycles.

[0231] In some embodiments, each R 10b These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10b These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Selected from alkyl groups. In some embodiments, each R 10b Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10b is independent:C 1~3 Selected from alkyl groups. In some embodiments, each R 10b is methyl. In some embodiments, each R 10b It is hydrogen.

[0232] In some embodiments, for a compound or salt of formula (II), each R 10c Independently: Hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon rings, substituted as needed with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6The haloalkyl group is selected from those that are optionally substituted with one or more substituents independently selected from the haloalkyl group.

[0233] In some embodiments, each R 10c These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 C is a carbon ring, or a 3-membered to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from these carbon rings. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10c These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10c These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally substituted with one or more substituents independently selected from the alkyl group. 1~6 Selected from alkyl groups. In some embodiments, each R 10c Independently: hydrogen; and C 1~6 Selected from alkyl groups. In some embodiments, each R 10c It is hydrogen.

[0234] In some embodiments, for a compound or salt of formula (II), each R 10d Independently: Hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkynnyl, where each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon rings, substituted as needed with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Selected from those independently of the haloalkyl, and optionally substituted with one or more substituents. In some embodiments, each R 10d These are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 C is a carbon ring, or a 3-membered to 10-membered heterocycle, optionally substituted with one or more substituents independently selected from these carbon rings. 1~6 Alkyl; and C 3~10 Selected from carbocyclic rings and 3- to 10-membered heterocycles. In some embodiments, each R 10dThese are independently: hydrogen; as well as halogens, -CN, -OH, -SH, -NO2, -NH2, =O, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 C (alkyl) optionally subst...

Claims

[Claim 1] The invention described herein.

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