Acetamido-phenyltetrazole derivative and method of use thereof

Abstract

The present invention provides compounds for the regulation of P-glycoprotein and cytochrome P450 (e.g., CYP3A4 and CYP3A5 isoforms) enzymes, which a) significantly improve the bioavailability of substrates of these enzymes, including anticancer drugs, b) overcome multidrug resistance in tumors, and c) reduce serious side effects while improving the delivery of P-glycoprotein substrates to the brain. [Solution] Compounds of formula (IA), as well as their prodrugs, pharmaceutically acceptable salts, and pharmaceutical compositions are used. The disclosure further relates to methods for using these compounds and methods for preparing them. TIFF2026090442000253.tif29128

Description

[Technical Field]

[0001] Related applications This application claims priority and benefits of U.S. Provisional Application No. 63 / 088,778, filed on 7 October 2020, which is incorporated herein by reference in its entirety.

[0002] Areas of disclosure This disclosure relates to acetamido-phenyltetrazole derivatives that have modulatory activity on P-glycoprotein and / or drug-metabolizing enzymes cytochrome P450 (e.g., CYP3A4 and / or CYP3A5 isoforms) and are useful for the treatment of the human or animal body. This disclosure also relates to methods for preparing these compounds, pharmaceutical compositions comprising them, and their use in the treatment of disorders in which the expression of P-glycoprotein and / or cytochrome P450 isoforms (e.g., CYP3A4 or CYP3A5) is regulated (e.g., cancers that have developed multidrug resistance). This disclosure also relates to the use of the compounds of this disclosure to improve the oral bioavailability of therapeutics that are substrates of P-glycoprotein and / or cytochrome P450. This disclosure also relates to the use of the compounds of this disclosure to increase the brain distribution of therapeutics that are substrates of P-glycoprotein and / or cytochrome P450. [Background technology]

[0003] background Many anticancer drugs (e.g., vinca alkaloids, anthracyclines, epipodophyllotoxin, paclitaxel, and docetaxel) become ineffective when administered to patients with multidrug resistance (MDR) caused by the presence of overexpressed P-glycoprotein. P-glycoprotein regulates the intracellular accumulation of administered anticancer drugs by pushing them out of tumor cells. The expression of the drug-metabolizing CYP3A4 protein in breast tumors, colorectal tumors, esophageal tumors, and Ewing's sarcomas can suppress the intracellular concentration of anticancer drugs by forming metabolites with reduced antitumor activity. This action of CYP3A4 limits the effectiveness of anticancer drugs or contributes to the development of resistance to them. Modulation of P-glycoprotein and / or cytochrome P450 enzymes (e.g., CYP3A4) in tumor cells can increase the sensitivity of these cells to anticancer drugs.

[0004] P-glycoprotein is expressed in normal, healthy tissues, such as the small intestine. Intestinal P-glycoprotein does not allow its substrates to pass through the epithelial cells lining the intestinal wall, thus reducing the oral bioavailability of these substrates. Furthermore, anticancer drugs may undergo first-pass metabolism by cytochrome P450 enzymes (e.g., CYP3A4 and / or CYP3A5 isoforms) present in the small intestine and liver, further reducing their oral bioavailability. Therefore, it is necessary to improve the bioavailability of anticancer drugs through dual-targeting modulation of both P-glycoprotein and cytochrome P450 enzymes (e.g., CYP3A4 and / or CYP3A5 isoforms).

[0005] Furthermore, the localization of P-glycoprotein within endothelial cells of the blood-brain barrier significantly restricts the transport of P-glycoprotein substrates from the blood to the brain. Regulating P-glycoprotein at the blood-brain barrier may be beneficial in the treatment of several central nervous system (CNS) disorders, such as brain tumors like glioblastoma.

[0006] Conventional P-glycoprotein modulators, such as verapamil and cyclosporine A, cause significant adverse effects (e.g., hypotension and immunosuppression). Therefore, several novel P-glycoprotein modulators have been developed, such as derivatives of piperidine-2-carboxylate, acridine, piperazine-2,5-dione, anthranilic acid, and metanodibenzosverane. However, these newly introduced P-glycoprotein modulators have been reported to exhibit toxicity and other adverse effects. This disclosure arises from the need to provide further compounds for the modulation of P-glycoprotein and cytochrome P450 (e.g., CYP3A4 and CYP3A5 isoforms) enzymes that a) significantly improve the bioavailability of substrates of these enzymes, including anticancer drugs, b) overcome multidrug resistance in tumors, and c) reduce significant side effects while improving the delivery of P-glycoprotein substrates to the brain. [Overview of the Initiative]

[0007] overview In one aspect, this disclosure provides compounds of formula (IA), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000001.tif39128 formula, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6It is a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 alkyl, C 2~6 alkenyl, or C 2~6 alkynyl; R2 and R3 are each independently H, C 2~6 alkenyl, C 2~6 alkynyl, -O-C 1~6 alkyl, -O-C 2~6 alkenyl, -O-C 2~6 alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, where the -O-C 1~6 alkyl, -O-C 2~6 alkenyl, or -O-C 2~6 alkynyl may be substituted with C 6~10 aryl, or a 5- to 13-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R5 and R6 are each independently H, C 1~6 alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 3~10 cycloalkyl, a 3- to 13-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6~10A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7s, and both R7s are -O-methyl, (a) One of R2 and R3 is not -O-methyl; or, (b) R x or R y It is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0008] In one aspect, this disclosure provides compounds of formula (I), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000002.tif39128 formula, A is C 3~10A 3- to 14-member heterocyclyl containing 1 to 4 heteroatoms selected from cycloalkyl, N, O, and S, C 6~10 aryl, or a 5- to 14-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with oxo; R x and R y are each independently H, C 1~6 alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 alkoxy, halogen, -CN, -OH, -NH2, a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 alkyl, C 2~6 alkenyl, or C 2~6 alkynyl; R2 and R3 are each independently H, C 2~6 alkenyl, C 2~6 alkynyl, -O-C 1~6 alkyl, -O-C 2~6 alkenyl, -O-C 2~6 alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, where the -O-C 1~6 alkyl, -O-C 2~6 alkenyl, or -O-C 2~6 alkynyl is C 6~10It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl.

[0009] In one aspect, this disclosure provides compounds of formula (I'), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000003.tif39128In formula, A is The filename is TIFF2026090442000004.tif21162; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl.

[0010] In one aspect, this disclosure provides compounds of formula (II), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000005.tif39128In formula, R x H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl.

[0011] In one aspect, this disclosure provides compounds of formula (IA'), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000006.tif39128In formula, A is C 3~10Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y Each is independently a 5-10 membered heteroaryl compound containing 1-4 heteroatoms selected from H, or N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independently H, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkynyl, or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R2 and R3 are not H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 is independent of C 1~6 It is an alkoxy; n, m, and p are each independently either 0 or 1. Here, (a) one of R2 and R3 is not -O-methyl; or (b) R x or R yIt is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0012] In one aspect, this disclosure provides compounds that can or may be obtained by methods for preparing the compounds described herein (for example, methods comprising one or more steps described in schemes 1 to 6).

[0013] In one aspect, the present disclosure provides a pharmaceutical composition comprising a compound of the present disclosure, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, and a pharmaceutically acceptable diluent or carrier.

[0014] In one aspect, this disclosure provides intermediates described herein that are suitable for use in methods for preparing the compounds described herein (for example, the intermediates are selected from the intermediates described in Examples 1 to 16).

[0015] In one aspect, the present disclosure provides a method for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo) comprising the step of contacting a cell with an effective amount of the compound of the present disclosure, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

[0016] In one aspect, the present disclosure provides a method for treating or preventing a disease or disorder disclosed herein in a subject where such treatment is needed, the method comprising administering to the subject a therapeutically effective amount of a compound of the present disclosure, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, or a pharmaceutically acceptable pharmaceutically composition thereof.

[0017] In one aspect, the present disclosure provides the compounds of the present disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, for use in modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo).

[0018] In one aspect, the Disclosure provides the compounds of the Disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, for use in treating or preventing the diseases or disorders disclosed herein.

[0019] In one aspect, the present disclosure provides the use of the compounds of the present disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, in the manufacture of pharmaceuticals for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo).

[0020] In one aspect, the Disclosure provides the use of the Compounds of the Disclosure, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof, in the manufacture of a medicament for treating or preventing a disease or disorder disclosed herein.

[0021] In one aspect, the present disclosure provides a method for preparing the compounds of the present disclosure.

[0022] In one aspect, this disclosure provides a method for preparing a compound, comprising one or more steps described herein.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art in which this disclosure pertains. In this specification, singular nouns also include plural nouns unless otherwise clearly indicated by the context. Methods and materials similar to or equivalent to those described herein may be used in the implementation or testing of this disclosure, but preferred methods and materials are described below. All publications, patent applications, patents, and other references referenced herein are incorporated by reference. References cited herein are not considered prior art to this disclosure. In case of any conflict, this specification, including definitions, shall prevail. Furthermore, materials, methods, and examples are illustrative only and are not intended to be limiting. In case of any conflict between a chemical structure and the name of a compound disclosed herein, the chemical structure shall prevail.

[0024] [Invention 1001] Compounds of formula (IA), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026090442000007.tif39128In formula, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~105-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7s, and both R7s are -O-methyl, (a) One of R2 and R3 is not -O-methyl; or, (b) R x or R y It is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. [Invention 1002] Compounds of formula (I), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026090442000008.tif39128In formula, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl. [Invention 1003] Compounds of formula (I'), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026090442000009.tif39128In formula, A is The filename is TIFF2026090442000010.tif23164; Rx and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl. [Invention 1004] Compounds of formula (II), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026090442000011.tif40128 formula, R x H, C 1~6 Alkyl, C 2~6 Alkenil, C2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl. [Invention 1005] Compounds of formula (IA'), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: TIFF2026090442000012.tif39128 formula, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y Each is independently a 5-10 membered heteroaryl compound containing 1-4 heteroatoms selected from H, or N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independently H, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkynyl, or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R2 and R3 are not H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 is independent of C 1~6 It is an alkoxy; n, m, and p are each independently either 0 or 1. Here, (a) one of R2 and R3 is not -O-methyl; or (b) R x or R y It is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. [Invention 1006] R x and R y H and C are independent of each other. 1~6A compound of the present invention that is alkyl or -OH. [Invention 1007] R1 is H or C 1~6 A compound of the present invention that is alkyl. [Invention 1008] R2 and R3 each operate independently, -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1009] R5 and R6 are independent of each other, H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Any of the compounds of the present invention, which is a 5- to 13-membered heteroaryl or -C(O)R7 comprising 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms. [Invention 1010] R5 and R6 are independent of each other, H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 Any of the compounds of the present invention described above, which are aryl, or 5-13 membered heteroaryls comprising 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms. [Invention 1011] R5 and R6 are independent of each other, H, C 1~6 Alkyl, C 3~10Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A compound according to the present invention, which is a 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms. [Invention 1012] Any of the compounds of the present invention, wherein R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl is substituted with one or more R7s. [Invention 1013] Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R. 10 , C 1~3 Alkyl, C 2~6 Alkinyl, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, alkoxy, aryl, or heteroaryl is one or more R 10 Any of the compounds of the present invention described above, which may be substituted with. [Invention 1014] Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R. 10 , C 1~3 Alkyl, C 2~6 Alkinyl, C 1~6 Alkoxy, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, alkoxy, aryl, or heteroaryl is one or more R 10Any of the compounds of the present invention that are substituted with the above. [Invention 1015] R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -N(C) 1~6 Alkyl)2,-S(C 1~6 A compound of the present invention, which is a 3-10 membered heterocyclyl comprising 1-4 heteroatoms selected from alkyl, N, O, and S, or a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl may be substituted with one or more R9 atoms. [Invention 1016] R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -N(C) 1~6 Alkyl)2,-S(C 1~6 A compound of the present invention, comprising a 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from alkyl, N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl is substituted with one or more R9 atoms. [Invention 1017] Each R9 independently, -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 Any of the compounds of the present invention described above, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups. [Invention 1018] Each R9 independently, -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10A compound of the present invention, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups. [Invention 1019] Each R 10 C 1~6 Alkyl, C 1~6 Any of the compounds of the present invention described above, which are haloalkyl or 5-10 membered heteroaryl compounds containing 1-4 heteroatoms selected from N, O, and S. [Invention 1020] Each R 11 They became independent, H; One or more 3-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6~10 aryl, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1~6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1~6 Any of the compounds of the present invention described above, which may be substituted with alkyl or oxo. [Invention 1021] Each R 11 They became independent, H; One or more 3-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6~10 aryl, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1~6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1~6Any of the compounds of the present invention described above, which are substituted with alkyl or oxo. [Invention 1022] Each R 11 They became independent, H; One or more 3-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6~10 aryl, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S Replaced with, C 1~6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1~6 Any of the compounds of the present invention described above, which may be substituted with alkyl or oxo. [Invention 1023] 2 R 11 However, together with the atoms to which they are bonded, One or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl, halogen, -CN, -OH, or -NH2 A 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted. A compound of the present invention that forms any of the above-mentioned compounds. [Invention 1024] 2 R 11 However, together with the atoms to which they are bonded, One or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkynyl, halogen, -CN, -OH, or -NH2 4-10 membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, substituted with A compound of the present invention that forms any of the above-mentioned compounds. [Invention 1025] Any of the compounds of the present invention described above, wherein each n is 0. [Invention 1026] Any of the compounds of the present invention, wherein each n is 1. [Invention 1027] Any of the compounds of the present invention, wherein each m is 0. [Invention 1028] Any of the compounds of the present invention, wherein each m is 1. [Invention 1029] Any of the compounds of the present invention, wherein each p is 0. [Invention 1030] Any of the compounds of the present invention described above, wherein each p is 1. [Invention 1031] A compound of the present invention in which neither R2 nor R3 is H. [Invention 1032] Any of the compounds of the present invention, wherein R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7s, one of which R7 is not -O-methyl. [Invention 1033] Compounds of formula (Ia) or (Ib): A compound according to any of the inventions 1001 to 1003, which is TIFF2026090442000013.tif77128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1034] Compounds of formula (Ic), (Id), (Ie), or (If): A compound according to any of the inventions 1001 to 1003, which is TIFF2026090442000014.tif164128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1035] Compounds of formula (I-a') or (I-b'): A compound according to any of the inventions 1001 to 1003, which is TIFF2026090442000015.tif77128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1036] Compound of formula (II-a): A compound according to any of the present invention 1001 to 1004, which is TIFF2026090442000016.tif42128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1037] Compound of formula (II-a'): A compound according to any of the inventions 1001 to 1004, which is TIFF2026090442000017.tif42128, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof. [Invention 1038] A compound selected from Table 1, any of the compounds 1001 to 1005 of the present invention. [Invention 1039] A compound of the present invention 1001 or 1005, selected from Table 2. [Invention 1040] A pharmaceutical composition comprising any compound 1001 to 1039 of the present invention, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, and a pharmaceutically acceptable diluent or carrier. [Invention 1041] A method for modulating P-glycoprotein activity and / or cytochrome P450 activity, comprising the step of contacting a cell with an effective amount of any compound from Invention 1001 to 1039 or a pharmaceutical composition of Invention 1040. [Invention 1042] A method for treating or preventing cancer in a subject in need, comprising the step of administering to the subject a therapeutically effective amount of any compound from 1001 to 1039 of the present invention or a pharmaceutical composition of 1040 of the present invention. [Invention 1043] A compound from any of Invention 1001 to 1039 or a pharmaceutical composition of Invention 1040 for use in modulating P-glycoprotein activity and / or cytochrome P450 activity. [Invention 1044] A compound of any of Invention 1001 to 1039 or a pharmaceutical composition of Invention 1040 for use in treating or preventing any of the diseases or disorders disclosed herein. [Invention 1045] Use of any compound from Invention 1001 to 1039 or a pharmaceutical composition of Invention 1040 in the manufacture of a pharmaceutical for modulating P-glycoprotein activity and / or cytochrome P450 activity. [Invention 1046] Use of any compound from Invention 1001 to 1039 or a pharmaceutical composition of Invention 1040 in the manufacture of a pharmaceutical for treating or preventing a disease or disorder disclosed herein. Other features and advantages of this disclosure will be apparent from the following detailed description and claims. [Modes for carrying out the invention]

[0025] Detailed explanation Compounds of the Disclosure In one aspect, this disclosure provides compounds of formula (IA), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000018.tif39128In formula, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7s, and both R7s are -O-methyl, (a) One of R2 and R3 is not -O-methyl; or, (b) R x or R y It is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0026] In one aspect, this disclosure provides compounds of formula (I), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000019.tif39128In formula, A is C 3~10Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl.

[0027] In one aspect, the present disclosure provides a compound of formula (I'), or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof: TIFF2026090442000020.tif39128 wherein, A is TIFF2026090442000021.tif21162; R x and R y are each independently H, C 1~6 alkyl, C 2~6 alkenyl, C 2~6 alkynyl, C 1~6 alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from the group consisting of, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S; R1 is H, C 1~6 alkyl, C 2~6 alkenyl, or C 2~6 alkynyl; R2 and R3 are each independently H, C 2~6 alkenyl, C 2~6 alkynyl, -O-C 1~6 alkyl, -O-C 2~6 alkenyl, -O-C 2~6 alkynyl, -C(O)R 11 , -C(O)OR 11 , -C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 , -C(O)NR 11 -S(O)2-OR 11 , -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S), where neither R2 nor R3 is H, where the -O-C 1~6 alkyl, -O-C 2~6 alkenyl, or -O-C 2~6 alkynyl is C 6~10It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C2~6 is alkenyl or C 2~6 is alkynyl, wherein the alkyl, alkenyl, or alkynyl is substituted with one or more C 3~10 is cycloalkyl, a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6~10 may be substituted with aryl or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more C 3~10 is cycloalkyl, a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6~10 is aryl, a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, C 1~6 is alkyl, C 2~6 is alkenyl, C 2~6 is alkynyl, oxo, halogen, -CN, -OH, or -NH2, or two Rs 11 together with the atoms to which they are attached form a 4- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl is substituted with one or more C 1~6 is alkyl, C 2~6 is alkenyl, C 2~6 is alkynyl, halogen, -CN, -OH, or -NH2, and may be substituted; n, m, and p are each independently 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3, wherein when R5 and R6 together with the atoms to which they are attached form a heterocyclyl or heteroaryl substituted with two R7s, one of the R7s is not -O-methyl.

[0028] In one aspect, this disclosure provides compounds of formula (II), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000022.tif39128 formula, R x H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 A 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independent of H and C, respectively. 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6 are independently H and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 independently produces oxo, halogen, -OH, -NH2, -CN, and -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R8 -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms; Each R9 is independent of -(CH2) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6~10 A heteroaryl or aryl, where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH2; Each R 10 These are independently halogen, -OH, -NH2, -CN, and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Haloalkyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is a 5-10 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, oxo, halogen, -CN, -OH, or -NH2, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 They may be substituted with alkynyl, halogen, -CN, -OH, or -NH2; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, if R5 and R6, together with the atom to which they are bonded, form a heterocyclyl or heteroaryl substituted with two R7 atoms, then one of the R7 atoms is not -O-methyl.

[0029] In one aspect, this disclosure provides compounds of formula (IA'), or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts thereof: TIFF2026090442000023.tif39128In formula, A is C 3~10Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y Each is independently a 5-10 membered heteroaryl compound containing 1-4 heteroatoms selected from H, or N, O, and S; R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl; R2 and R3 are independently H, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkynyl, or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R2 and R3 are not H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S; R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl may be substituted with one or more R7s; Each R7 is independent of C 1~6 It is an alkoxy; n, m, and p are each independently either 0 or 1. Here, (a) one of R2 and R3 is not -O-methyl; or (b) R x or R yIt is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0030] For compounds of formula (IA), (I), (I'), (II), or (IA'), A, R x、 R y , R1, R2, R3, R5, R6, R7, R8, R9, R 10 , R 11 n, m, p, t, and u can be appropriately selected from the bases described herein, and A, R x、 R y , R1, R2, R3, R5, R6, R7, R8, R9, R 10 , R 11 A, R x、 R y , R1, R2, R3, R5, R6, R7, R8, R9, R 10 , R 11 It will be understood that one or more of the remaining n, m, p, t, and u can be appropriately combined with any of the bases described herein.

[0031] In some embodiments, the N atom of the compound is an N-oxide.

[0032] In some embodiments, N-oxide is formula It has TIFF2026090442000024.tif16128, and in the formula, TIFF2026090442000025.tif9128 shows the binding to compounds of formula (IA), (I), (I'), (II), or (IA').

[0033] In some embodiments, N-oxide is formula It has TIFF2026090442000026.tif14128, and in the formula, TIFF2026090442000027.tif9128 shows the binding to compounds of formula (IA), (I), (I'), (II), or (IA').

[0034] In some embodiments, N-oxide is formula It has TIFF2026090442000028.tif15128, and in the formula, TIFF2026090442000029.tif9128 shows the binding to compounds of formula (IA), (I), (I'), (II), or (IA').

[0035] In some aspects, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-14 member heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo.

[0036] In some aspects, A is C 3~10 Cycloalkyl, 3-14 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0037] In some aspects, A is C 3~10 A cycloalkyl or a 3-14 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with an oxo.

[0038] In some aspects, A is C 3~10 It is a cycloalkyl or a 3- to 14-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0039] In some embodiments, C may be substituted with an oxo. 3~10 It is a cycloalkyl group.

[0040] In some embodiments, A is a C3 cycloalkyl group. In some embodiments, A is a C4 cycloalkyl group. In some embodiments, A is a C5 cycloalkyl group. In some embodiments, A is a C6 cycloalkyl group. In some embodiments, A is a C7 cycloalkyl group. In some embodiments, A is a C8 cycloalkyl group. In some embodiments, A is a C9 cycloalkyl group. In some embodiments, A is a C 10 It is a cycloalkyl group.

[0041] In some embodiments, A is a C3 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C4 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C5 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C6 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C7 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C8 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C9 cycloalkyl which may be oxo-substituted. In some embodiments, A is a C 10 It is a cycloalkyl group.

[0042] In some embodiments, A is a C3-C7 monocyclic cycloalkyl. In some embodiments, A is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, A is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, A is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, A is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, A is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, A is C8~C 10 It is a polycyclic cycloalkyl group.

[0043] In some embodiments, A is a C3-C7 monocyclic cycloalkyl that may be oxo-substituted. In some embodiments, A is a C3-C7 monocyclic saturated cycloalkyl that may be oxo-substituted. In some embodiments, A is a C3-C7 monocyclic partially saturated cycloalkyl that may be oxo-substituted. In some embodiments, A is a C9-C7 monocyclic cycloalkyl that may be oxo-substituted. 10 It is a bicyclic cycloalkyl. In some embodiments, A may be substituted with an oxo molecule. C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, A may be substituted with an oxo molecule. C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, A may be substituted with an oxo C8-C 10 It is a polycyclic cycloalkyl group.

[0044] In some embodiments, A is a 3- to 14-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0045] In some embodiments, A is a 3- to 14-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0046] In some embodiments, A is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0047] In some embodiments, A is a 3- to 10-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0048] In some embodiments, A is a three-membered heterocycline containing one heteroatom selected from N, O, and S. In some embodiments, A is a four-membered heterocycline containing one to two heteroatoms selected from N, O, and S. In some embodiments, A is a five-membered heterocycline containing one to three heteroatoms selected from N, O, and S. In some embodiments, A is a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a ten-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 14-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0049] In some embodiments, A is a three-membered heterocycline containing one heteroatom selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a four-membered heterocycline containing one to two heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a five-membered heterocycline containing one to three heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with an oxo. In some embodiments, A is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 14-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0050] In some embodiments, A is a 7-10 membered bicyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0051] In some embodiments, A is a 7-10 membered bicyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0052] In some embodiments, A is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0053] In some embodiments, A is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos. In some embodiments, A is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0054] In some embodiments, A is an 8-14 membered polycyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0055] In some embodiments, A is an 8-14 membered polycyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0056] In some embodiments, A is an 8-10 membered polycyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0057] In some embodiments, A is an 8-10 membered polycyclic heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0058] In some embodiments, A is a 14-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0059] In some embodiments, A is a 14-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with oxos.

[0060] In some embodiments, A is a 14-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with oxo atoms.

[0061] In some aspects, A is C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0062] In some aspects, A is C 6~10 It is an aryl compound. In some embodiments, A is a C5-C6 aryl compound. In some embodiments, A is a phenyl compound.

[0063] In some embodiments, A is a 5- to 14-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0064] In some embodiments, A is a 5-10 membered heteroaryl compound containing 1-4 heteroatoms selected from N, O, and S.

[0065] In some embodiments, A is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, A is a 14-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0066] In some embodiments, A is a 9-10 membered bicyclic heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0067] In some embodiments, A is a nine-membered bicyclic heteroaryl compound containing one to four heteroatoms selected from N, O, and S. In some embodiments, A is a ten-membered bicyclic heteroaryl compound containing one to four heteroatoms selected from N, O, and S.

[0068] In some embodiments, A is a 9-10 membered polycyclic heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0069] In some aspects, A is The filename is TIFF2026090442000030.tif23164.

[0070] In some aspects, A is The filename is TIFF2026090442000031.tif22128.

[0071] In some aspects, A is The filename is TIFF2026090442000032.tif21128.

[0072] In some aspects, A is The filename is TIFF2026090442000033.tif15128.

[0073] In some aspects, A is The filename is TIFF2026090442000034.tif15128.

[0074] In some aspects, A is The filename is TIFF2026090442000035.tif22128.

[0075] In some embodiments, R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 These are 3- to 10-membered heterocyclines containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or 5- to 10-membered heteroaryls containing 1 to 4 heteroatoms selected from N, O, and S.

[0076] In some embodiments, R x and R y These are H and C, which are independent of each other. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0077] In some embodiments, R x and R y These are H.

[0078] In some embodiments, R x and R y Each is independent of C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 These are 3- to 10-membered heterocyclines containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or 5- to 10-membered heteroaryls containing 1 to 4 heteroatoms selected from N, O, and S.

[0079] In some embodiments, R x and R y Each is independent of C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0080] In some embodiments, R x and R y Each is independently a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0081] In some embodiments, R x and R y These are H and C, which are independent of each other. 1~6 It is alkyl or -OH.

[0082] In some embodiments, R x H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6These are 3- to 10-membered heterocyclines containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or 5- to 10-membered heteroaryls containing 1 to 4 heteroatoms selected from N, O, and S.

[0083] In some embodiments, R x H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0084] In some embodiments, R x H is H.

[0085] In some embodiments, R x is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 These are 3- to 10-membered heterocyclines containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or 5- to 10-membered heteroaryls containing 1 to 4 heteroatoms selected from N, O, and S.

[0086] In some embodiments, R x is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0087] In some embodiments, R x is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, or C 1~6 It is an alkoxy.

[0088] In some embodiments, R x is C 1~6 Alkyl, C2~6 Alkenyl, or C 2~6 It is alkinyl.

[0089] In some embodiments, R x is C 1~6 It is alkyl. In some embodiments, R x is methyl. In some embodiments, R x is ethyl. In some embodiments, R x is propyl. In some embodiments, R x is butyl. In some embodiments, R x is pentyl. In some embodiments, R x is hexyl. In some embodiments, R x is isopropyl. In some embodiments, R x is isobutyl. In some embodiments, R x is isopentyl. In some embodiments, R x is isohexyl. In some embodiments, R x is secbutyl. In some embodiments, R x secpentyl is secpentyl. In some embodiments, R x is sec hexyl. In some embodiments, R x It is tert-butyl.

[0090] In some embodiments, R x is C 2~6 It is an alkenil. In some embodiments, R x is a C2 alkenyl. In some embodiments, R x is a C3 alkenyl. In some embodiments, R x is a C4 alkenyl. In some embodiments, R x is a C5 alkenyl. In some embodiments, R x This is a C6 alkenyl.

[0091] In some embodiments, R x is C 2~6 It is alkinyl. In some embodiments, R xis C2 alkynyl. In some embodiments, R x is C3 alkynyl. In some embodiments, R x is C4 alkynyl. In some embodiments, R x is C5 alkynyl. In some embodiments, R x This is a C6 alkynyl.

[0092] In some embodiments, R x is C 1~6 It is an alkoxy. In some embodiments, R x is methoxy. In some embodiments, R x is ethoxy. In some embodiments, R x is a propoxy. In some embodiments, R x is butoxy. In some embodiments, R x is pentoxy. In some embodiments, R x It is hexoxy.

[0093] In some embodiments, R x These are halogens, -CN, -OH, or -NH2.

[0094] In some embodiments, R x is a halogen. In some embodiments, R x is F, Cl, Br, or I. In some embodiments, R x is F, Cl, or Br. In some embodiments, R x is F. In some embodiments, R x is Cl. In some embodiments, R x is Br. In some embodiments, R x It is I.

[0095] In some embodiments, R x is -CN. In some embodiments, R x is -OH. In some embodiments, R x It is -NH2.

[0096] In some embodiments, Rx These are 3-10 membered heterocyclyls containing 1-4 heteroatoms selected from N, O, and S, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S.

[0097] In some embodiments, R x It is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0098] In some embodiments, R x It is a three-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a four-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0099] In some embodiments, R x It is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0100] In some embodiments, R xIt is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x R is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x R is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0101] In some embodiments, each R x H, C 1~6 It is alkyl or -OH.

[0102] In some embodiments, R y H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 These are 3- to 10-membered heterocyclines containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or 5- to 10-membered heteroaryls containing 1 to 4 heteroatoms selected from N, O, and S.

[0103] In some embodiments, R y H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0104] In some embodiments, R y H is H.

[0105] In some embodiments, R y is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 These are 3- to 10-membered heterocyclines containing 1 to 4 heteroatoms selected from alkoxy, halogen, -CN, -OH, -NH2, N, O, and S, or 5- to 10-membered heteroaryls containing 1 to 4 heteroatoms selected from N, O, and S.

[0106] In some embodiments, R y is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 It is an alkoxy, halogen, -CN, -OH, or -NH2 group.

[0107] In some embodiments, R y is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, or C 1~6 It is an alkoxy.

[0108] In some embodiments, R y is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0109] In some embodiments, R y is C 1~6 It is alkyl. In some embodiments, R y is methyl. In some embodiments, R y is ethyl. In some embodiments, R y is propyl. In some embodiments, R y is butyl. In some embodiments, R y is pentyl. In some embodiments, R y is hexyl. In some embodiments, R y is isopropyl. In some embodiments, R yis isobutyl. In some embodiments, R y is isopentyl. In some embodiments, R y is isohexyl. In some embodiments, R y is secbutyl. In some embodiments, R y secpentyl is secpentyl. In some embodiments, R y is sec hexyl. In some embodiments, R y It is tert-butyl.

[0110] In some embodiments, R y is C 2~6 It is an alkenil. In some embodiments, R y is a C2 alkenyl. In some embodiments, R y is a C3 alkenyl. In some embodiments, R y is a C4 alkenyl. In some embodiments, R y is a C5 alkenyl. In some embodiments, R y This is a C6 alkenyl.

[0111] In some embodiments, R y is C 2~6 It is alkinyl. In some embodiments, R y is C2 alkynyl. In some embodiments, R y is C3 alkynyl. In some embodiments, R y is C4 alkynyl. In some embodiments, R y is C5 alkynyl. In some embodiments, R y This is a C6 alkynyl.

[0112] In some embodiments, R y is C 1~6 It is an alkoxy. In some embodiments, R y is methoxy. In some embodiments, R y is ethoxy. In some embodiments, R y is a propoxy. In some embodiments, R y is butoxy. In some embodiments, R yis pentoxy. In some embodiments, R y It is hexoxy.

[0113] In some embodiments, R y These are halogens, -CN, -OH, or -NH2.

[0114] In some embodiments, R y is a halogen. In some embodiments, R y is F, Cl, Br, or I. In some embodiments, R y is F, Cl, or Br. In some embodiments, R y is F. In some embodiments, R y is Cl. In some embodiments, R y is Br. In some embodiments, R y It is I.

[0115] In some embodiments, R y is -CN. In some embodiments, R y is -OH. In some embodiments, R y It is -NH2.

[0116] In some embodiments, R y These are 3-10 membered heterocyclyls containing 1-4 heteroatoms selected from N, O, and S, or 5-10 membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S.

[0117] In some embodiments, R y It is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0118] In some embodiments, R y It is a three-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a four-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R yIt is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0119] In some embodiments, R y It is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0120] In some embodiments, R y It is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y R is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y R is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0121] In some embodiments, each R y H, C1~6 It is alkyl or -OH.

[0122] In some embodiments, R1 is H, C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0123] In some embodiments, R1 is H.

[0124] In some embodiments, R1 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0125] In some embodiments, R1 is C 1~6 It is alkyl. In some embodiments, R1 is methyl. In some embodiments, R1 is ethyl. In some embodiments, R1 is propyl. In some embodiments, R1 is butyl. In some embodiments, R1 is pentyl. In some embodiments, R1 is hexyl. In some embodiments, R1 is isopropyl. In some embodiments, R1 is isobutyl. In some embodiments, R1 is isopentyl. In some embodiments, R1 is isohexyl. In some embodiments, R1 is sec-butyl. In some embodiments, R1 is sec-pentyl. In some embodiments, R1 is sec-hexyl. In some embodiments, R1 is tert-butyl.

[0126] In some embodiments, R1 is C 2~6 It is an alkenyl. In some embodiments, R1 is a C2 alkenyl. In some embodiments, R1 is a C3 alkenyl. In some embodiments, R1 is a C4 alkenyl. In some embodiments, R1 is a C5 alkenyl. In some embodiments, R1 is a C6 alkenyl.

[0127] In some embodiments, R1 is C 2~6It is an alkynyl. In some embodiments, R1 is a C2 alkynyl. In some embodiments, R1 is a C3 alkynyl. In some embodiments, R1 is a C4 alkynyl. In some embodiments, R1 is a C5 alkynyl. In some embodiments, R1 is a C6 alkynyl.

[0128] In some embodiments, each R1 is H or C 1~6 It is alkyl.

[0129] In some embodiments, R2 and R3 are independently H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0130] In some embodiments, R2 and R3 are independently H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0131] In some embodiments, R2 and R3 are independently H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0132] In some embodiments, R2 and R3 are independently H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11)2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H.

[0133] In some embodiments, R2 and R3 are independent of each other, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0134] In some embodiments, R2 and R3 are independent of each other, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0135] In some embodiments, R2 and R3 are independent of each other, -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 That is the case.

[0136] In some cases, neither R2 nor R3 is H.

[0137] In some embodiments, R2 is not H.

[0138] In some embodiments, R3 is not H.

[0139] In some embodiments, R2 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0140] In some embodiments, R2 is H, C 2~6 Alkenil, C 2~6Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0141] In some embodiments, R2 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0142] In some embodiments, R2 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0143] In some embodiments, R2 is H.

[0144] In some embodiments, R2 is C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0145] In some embodiments, R2 is C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR11 -S(O)2-N(R 11 )2.

[0146] In some embodiments, R2 is C 2~6 Alkenyl or C 2~6 It is alkinyl.

[0147] In some embodiments, R2 is C 2~6 It is an alkenyl. In some embodiments, R2 is a C2 alkenyl. In some embodiments, R2 is a C3 alkenyl. In some embodiments, R2 is a C4 alkenyl. In some embodiments, R2 is a C5 alkenyl. In some embodiments, R2 is a C6 alkenyl.

[0148] In some embodiments, R2 is C 2~6 It is an alkynyl. In some embodiments, R2 is a C2 alkynyl. In some embodiments, R2 is a C3 alkynyl. In some embodiments, R2 is a C4 alkynyl. In some embodiments, R2 is a C5 alkynyl. In some embodiments, R2 is a C6 alkynyl.

[0149] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0150] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0151] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be replaced with an aryl.

[0152] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 The alkynyl may be substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0153] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It is substituted with an aryl group or a 5- to 13-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0154] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It has been replaced with an aryl character.

[0155] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkynnyls are substituted with 5- to 13-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S.

[0156] In some embodiments, R2 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is alkinyl.

[0157] In some embodiments, R2 is C 6~10 -OC may be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 1~6 It is alkyl.

[0158] In some embodiments, R2 is C 6~10 It may be replaced with an aryl -OC 1~6 It is alkyl.

[0159] In some embodiments, R2 may be substituted with phenyl -OC 1~6 It is alkyl.

[0160] In some embodiments, R2 is a -O-methyl molecule which may be substituted with phenyl.

[0161] In some embodiments, R2 is substituted with phenyl-OC.1~6 It is alkyl.

[0162] In some embodiments, R2 is a phenyl-substituted -O-methyl molecule.

[0163] In some embodiments, R2 may be substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, -OC 1~6 It is alkyl.

[0164] In some embodiments, R2 is C 6~10 -OC substituted with aryl or 5- to 13-membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S 1~6 It is alkyl.

[0165] In some embodiments, R2 is C 6~10 -OC replaced with aryl 1~6 It is alkyl.

[0166] In some embodiments, R2 is substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, -OC 1~6 It is alkyl.

[0167] In some embodiments, R2 is -OC 1~6It is alkyl. In some embodiments, R2 is -O-methyl. In some embodiments, R2 is -O-ethyl. In some embodiments, R2 is -O-propyl. In some embodiments, R2 is -O-butyl. In some embodiments, R2 is -O-pentyl. In some embodiments, R2 is -O-hexyl. In some embodiments, R2 is -O-isopropyl. In some embodiments, R2 is -O-isobutyl. In some embodiments, R2 is -O-isopentyl. In some embodiments, R2 is -O-isohexyl. In some embodiments, R2 is -O-secbutyl. In some embodiments, R2 is -O-secpentyl. In some embodiments, R2 is -O-sechexyl. In some embodiments, R2 is -O-tertbutyl.

[0168] In some embodiments, R2 is C 6~10 -OC may be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 2~6 It is Alkenil.

[0169] In some embodiments, R2 is C 6~10 It may be replaced with an aryl -OC 2~6 It is Alkenil.

[0170] In some embodiments, R2 may be substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is Alkenil.

[0171] In some embodiments, R2 is C 6~10 -OC substituted with aryl or 5- to 13-membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S 2~6 It is Alkenil.

[0172] In some embodiments, R2 is C 6~10 -OC replaced with aryl 2~6It is Alkenil.

[0173] In some embodiments, R2 is substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is Alkenil.

[0174] In some embodiments, R2 is -OC 2~6 It is an alkenyl. In some embodiments, R2 is an -O-C2 alkenyl. In some embodiments, R2 is an -O-C3 alkenyl. In some embodiments, R2 is an -O-C4 alkenyl. In some embodiments, R2 is an -O-C5 alkenyl. In some embodiments, R2 is an -O-C6 alkenyl.

[0175] In some embodiments, R2 is C 6~10 -OC may be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 2~6 It is alkinyl.

[0176] In some embodiments, R2 is C 6~10 It may be replaced with an aryl -OC 2~6 It is alkinyl.

[0177] In some embodiments, R2 may be substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is alkinyl.

[0178] In some embodiments, R2 is C 6~10 -OC substituted with aryl or 5- to 13-membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S 2~6 It is alkinyl.

[0179] In some embodiments, R2 is C 6~10 -OC replaced with aryl 2~6 It is alkinyl.

[0180] In some embodiments, R2 is substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is alkinyl.

[0181] In some embodiments, R2 is -OC 2~6 It is an alkynyl. In some embodiments, R2 is an -O-C2 alkynyl. In some embodiments, R2 is an -O-C3 alkynyl. In some embodiments, R2 is an -O-C4 alkynyl. In some embodiments, R2 is an -O-C5 alkynyl. In some embodiments, R2 is an -O-C6 alkynyl.

[0182] In some embodiments, R2 is -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0183] In some embodiments, R2 is -C(O)R 11 , -C(O)OR 11 , or -C(O)N(R 11 )2.

[0184] In some embodiments, R2 is -C(O)R 11 In some embodiments, R2 is -C(O)OR 11 In some embodiments, R2 is -C(O)N(R 11 )2.

[0185] In some embodiments, R2 is -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11, or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0186] In some embodiments, R2 is -C(O)NR 11 -S(O)2R 11 In some embodiments, R2 is -C(O)NR 11 -S(O)2-OR 11 In some embodiments, R2 is -C(O)NR 11 -S(O)2-N(R 11 )2.

[0187] In some embodiments, R2 is -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 That is the case.

[0188] In some embodiments, R2 is a -O- (5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0189] In some embodiments, R2 is a -O- (5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R2 is a -O- (6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R2 is a -O- (7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R2 is an -O- (8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R2 is a -O- (9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R2 is a -O- (10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S).

[0190] In some embodiments, R2 is -O-methyl, phenyl-substituted -O-methyl, or -C(O)2CH3.

[0191] In some embodiments, R2 is -O-methyl or -O-methyl substituted with phenyl.

[0192] In some embodiments, R3 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where neither R2 nor R3 is H, and where the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0193] In some embodiments, R3 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11-S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2, and here neither R2 nor R3 is H, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0194] In some embodiments, R3 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0195] In some embodiments, R3 is H, C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R11 )2.

[0196] In some embodiments, R3 is H.

[0197] In some embodiments, R3 is C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O-(a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0198] In some embodiments, R3 is C 2~6 Alkenil, C 2~6 Alkinyl, -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0199] In some embodiments, R3 is C 2~6 Alkenyl or C 2~6 It is alkinyl.

[0200] In some embodiments, R3 is C2~6 It is an alkenyl. In some embodiments, R3 is a C2 alkenyl. In some embodiments, R3 is a C3 alkenyl. In some embodiments, R3 is a C4 alkenyl. In some embodiments, R3 is a C5 alkenyl. In some embodiments, R3 is a C6 alkenyl.

[0201] In some embodiments, R3 is C 2~6 It is an alkynyl. In some embodiments, R3 is a C2 alkynyl. In some embodiments, R3 is a C3 alkynyl. In some embodiments, R3 is a C4 alkynyl. In some embodiments, R3 is a C5 alkynyl. In some embodiments, R3 is a C6 alkynyl.

[0202] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, -OC 2~6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0203] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be substituted with an aryl or a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0204] In some embodiments, R3 is -OC 1~6Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It may be replaced with an aryl.

[0205] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 The alkynyl may be substituted with a 5-13 member heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0206] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It is substituted with an aryl group or a 5- to 13-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0207] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkinyl is C 6~10 It has been replaced with an aryl character.

[0208] In some embodiments, R3 is -OC 1~6 Alkyl, -OC2~6 Alkenyl, or -OC 2~6 It is an alkynyl, and here the -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 Alkynnyls are substituted with 5- to 13-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S.

[0209] In some embodiments, R3 is -OC 1~6 Alkyl, -OC 2~6 Alkenyl, or -OC 2~6 It is alkinyl.

[0210] In some embodiments, R3 is C 6~10 -OC may be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 1~6 It is alkyl.

[0211] In some embodiments, R3 is C 6~10 It may be replaced with an aryl -OC 1~6 It is alkyl.

[0212] In some embodiments, R3 may be substituted with phenyl -OC 1~6 It is alkyl.

[0213] In some embodiments, R3 is a -O-methyl molecule which may be substituted with phenyl.

[0214] In some embodiments, R3 is substituted with phenyl-OC 1~6 It is alkyl.

[0215] In some embodiments, R3 is a phenyl-substituted -O-methyl molecule.

[0216] In some embodiments, R3 may be substituted with a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S, -OC1~6 It is alkyl.

[0217] In some embodiments, R3 is C 6~10 -OC substituted with aryl or 5- to 13-membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S 1~6 It is alkyl.

[0218] In some embodiments, R3 is C 6~10 -OC replaced with aryl 1~6 It is alkyl.

[0219] In some embodiments, R3 is substituted with a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S, -OC 1~6 It is alkyl.

[0220] In some embodiments, R3 is -OC 1~6 It is alkyl. In some embodiments, R3 is -O-methyl. In some embodiments, R3 is -O-ethyl. In some embodiments, R3 is -O-propyl. In some embodiments, R3 is -O-butyl. In some embodiments, R3 is -O-pentyl. In some embodiments, R3 is -O-hexyl. In some embodiments, R3 is -O-isopropyl. In some embodiments, R3 is -O-isobutyl. In some embodiments, R3 is -O-isopentyl. In some embodiments, R3 is -O-isohexyl. In some embodiments, R3 is -O-secbutyl. In some embodiments, R3 is -O-secpentyl. In some embodiments, R3 is -O-sechexyl. In some embodiments, R3 is -O-tertbutyl.

[0221] In some embodiments, R3 is C 6~10 -OC may be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 2~6 It is Alkenil.

[0222] In some embodiments, R3 is C 6~10 It may be replaced with an aryl -OC 2~6 It is Alkenil.

[0223] In some embodiments, R3 may be substituted with a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is Alkenil.

[0224] In some embodiments, R3 is C 6~10 -OC substituted with aryl or 5- to 13-membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S 2~6 It is Alkenil.

[0225] In some embodiments, R3 is C 6~10 -OC replaced with aryl 2~6 It is Alkenil.

[0226] In some embodiments, R3 is substituted with a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is Alkenil.

[0227] In some embodiments, R3 is -OC 2~6 It is an alkenyl. In some embodiments, R3 is an -O-C2 alkenyl. In some embodiments, R3 is an -O-C3 alkenyl. In some embodiments, R3 is an -O-C4 alkenyl. In some embodiments, R3 is an -O-C5 alkenyl. In some embodiments, R3 is an -O-C6 alkenyl.

[0228] In some embodiments, R3 is C 6~10 -OC may be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S. 2~6 It is alkinyl.

[0229] In some embodiments, R3 is C 6~10 It may be replaced with an aryl -OC 2~6 It is alkinyl.

[0230] In some embodiments, R3 may be substituted with a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is alkinyl.

[0231] In some embodiments, R3 is C 6~10 -OC substituted with aryl or 5- to 13-membered heteroaryls containing 1-4 heteroatoms selected from N, O, and S 2~6 It is alkinyl.

[0232] In some embodiments, R3 is C 6~10 -OC replaced with aryl 2~6 It is alkinyl.

[0233] In some embodiments, R3 is substituted with a 5-13 member heteroaryl containing 1-4 heteroatoms selected from N, O, and S, -OC 2~6 It is alkinyl.

[0234] In some embodiments, R3 is -OC 2~6 It is an alkynyl. In some embodiments, R3 is an -O-C2 alkynyl. In some embodiments, R3 is an -O-C3 alkynyl. In some embodiments, R3 is an -O-C4 alkynyl. In some embodiments, R3 is an -O-C5 alkynyl. In some embodiments, R3 is an -O-C6 alkynyl.

[0235] In some embodiments, R3 is -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11, or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0236] In some embodiments, R3 is -C(O)R 11 , -C(O)OR 11 , or -C(O)N(R 11 )2.

[0237] In some embodiments, R3 is -C(O)R 11 In some embodiments, R3 is -C(O)OR 11 In some embodiments, R3 is -C(O)N(R 11 )2.

[0238] In some embodiments, R3 is -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 , or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0239] In some embodiments, R3 is -C(O)NR 11 -S(O)2R 11 In some embodiments, R3 is -C(O)NR 11 -S(O)2-OR 11 In some embodiments, R3 is -C(O)NR 11 -S(O)2-N(R 11 )2.

[0240] In some embodiments, R3 is -OC 1~6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 )2, or -C(O)NR 11 -S(O)2R 11 That is the case.

[0241] In some embodiments, R3 is a -O- (5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S).

[0242] In some embodiments, R3 is a -O- (5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R3 is a -O- (6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R3 is a -O- (7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R3 is an -O- (8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R3 is a -O- (9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S). In some embodiments, R3 is a -O- (10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S).

[0243] In some embodiments, R3 is -O-methyl, phenyl-substituted -O-methyl, or -C(O)2CH3.

[0244] In some embodiments, R3 is -O-methyl or -O-methyl substituted with phenyl.

[0245] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl may be substituted with one or more R7s.

[0246] In some embodiments, R5 and R6 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl or -C(O)R7 comprising 1-4 heteroatoms selected from aryl, N, O, and S, where the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms, or R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl may be substituted with one or more R7s.

[0247] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0248] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0249] In some embodiments, R5 and R6 are H independently.

[0250] In some embodiments, R5 and R6 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0251] In some embodiments, R5 and R6 are independent of each other, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0252] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl or -C(O)R7 containing 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0253] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0254] In some embodiments, R5 and R6 are independently H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms.

[0255] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl is substituted with one or more R7s.

[0256] In some embodiments, R5 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0257] In some embodiments, R5 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0258] In some embodiments, R5 is H.

[0259] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0260] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0261] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0262] In some embodiments, R5 may be replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R5 is methyl, which may be substituted with one or more R7s. In some embodiments, R5 is ethyl, which may be substituted with one or more R7s. In some embodiments, R5 is propyl, which may be substituted with one or more R7s. In some embodiments, R5 is butyl, which may be substituted with one or more R7s. In some embodiments, R5 is pentyl, which may be substituted with one or more R7s. In some embodiments, R5 is hexyl, which may be substituted with one or more R7s. In some embodiments, R5 is isopropyl, which may be substituted with one or more R7s. In some embodiments, R5 is isobutyl, which may be substituted with one or more R7s. In some embodiments, R5 is isopentyl, which may be substituted with one or more R7s. In some embodiments, R5 is isohexyl, which may be substituted with one or more R7s. In some embodiments, R5 is secbutyl, which may be substituted with one or more R7s. In some embodiments, R5 is sec-pentyl which may be substituted with one or more R7 atoms. In some embodiments, R5 is sec-hexyl which may be substituted with one or more R7 atoms. In some embodiments, R5 is tert-butyl which may be substituted with one or more R7 atoms.

[0263] In some embodiments, R5 may be replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C3 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C4 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C5 alkenyl which may be substituted with one or more R7s. In some embodiments, R5 is a C6 alkenyl which may be substituted with one or more R7s.

[0264] In some embodiments, R5 may be replaced by one or more R7s. 2~6 It is an alkynyl. In some embodiments, R5 is a C2 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C3 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C4 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C5 alkynyl which may be substituted with one or more R7s. In some embodiments, R5 is a C6 alkynyl which may be substituted with one or more R7s.

[0265] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0266] In some embodiments, R5 is replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R5 is methyl substituted with one or more R7s. In some embodiments, R5 is ethyl substituted with one or more R7s. In some embodiments, R5 is propyl substituted with one or more R7s. In some embodiments, R5 is butyl substituted with one or more R7s. In some embodiments, R5 is pentyl substituted with one or more R7s. In some embodiments, R5 is hexyl substituted with one or more R7s. In some embodiments, R5 is isopropyl substituted with one or more R7s. In some embodiments, R5 is isobutyl substituted with one or more R7s. In some embodiments, R5 is isopentyl substituted with one or more R7s. In some embodiments, R5 is isohexyl substituted with one or more R7s. In some embodiments, R5 is secbutyl substituted with one or more R7s. In some embodiments, R5 is sec-pentyl substituted with one or more R7 atoms. In some embodiments, R5 is sec-hexyl substituted with one or more R7 atoms. In some embodiments, R5 is tert-butyl substituted with one or more R7 atoms.

[0267] In some embodiments, R5 is replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C3 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C4 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C5 alkenyl substituted with one or more R7s. In some embodiments, R5 is a C6 alkenyl substituted with one or more R7s.

[0268] In some embodiments, R5 is replaced by one or more R7s. 2~6It is an alkynyl. In some embodiments, R5 is a C2 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C3 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C4 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C5 alkynyl substituted with one or more R7s. In some embodiments, R5 is a C6 alkynyl substituted with one or more R7s.

[0269] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is substituted with one R7.

[0270] In some embodiments, R5 is replaced by a single R7. 1~6 It is alkyl. In some embodiments, R5 is methyl substituted with one R7. In some embodiments, R5 is ethyl substituted with one R7. In some embodiments, R5 is propyl substituted with one R7. In some embodiments, R5 is butyl substituted with one R7. In some embodiments, R5 is pentyl substituted with one R7. In some embodiments, R5 is hexyl substituted with one R7. In some embodiments, R5 is isopropyl substituted with one R7. In some embodiments, R5 is isobutyl substituted with one R7. In some embodiments, R5 is isopentyl substituted with one R7. In some embodiments, R5 is isohexyl substituted with one R7. In some embodiments, R5 is secbutyl substituted with one R7. In some embodiments, R5 is secpentyl substituted with one R7. In some embodiments, R5 is sec-hexyl substituted with one R7. In some embodiments, R5 is tert-butyl substituted with one R7.

[0271] In some embodiments, R5 is replaced by a single R7.2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl substituted with one R7. In some embodiments, R5 is a C3 alkenyl substituted with one R7. In some embodiments, R5 is a C4 alkenyl substituted with one R7. In some embodiments, R5 is a C5 alkenyl substituted with one R7. In some embodiments, R5 is a C6 alkenyl substituted with one R7.

[0272] In some embodiments, R5 is replaced by a single R7. 2~6 It is an alkynyl. In some embodiments, R5 is a C2 alkynyl substituted with one R7. In some embodiments, R5 is a C3 alkynyl substituted with one R7. In some embodiments, R5 is a C4 alkynyl substituted with one R7. In some embodiments, R5 is a C5 alkynyl substituted with one R7. In some embodiments, R5 is a C6 alkynyl substituted with one R7.

[0273] In some embodiments, R5 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0274] In some embodiments, R5 is C 1~6 It is alkyl. In some embodiments, R5 is methyl. In some embodiments, R5 is ethyl. In some embodiments, R5 is propyl. In some embodiments, R5 is butyl. In some embodiments, R5 is pentyl. In some embodiments, R5 is hexyl. In some embodiments, R5 is isopropyl. In some embodiments, R5 is isobutyl. In some embodiments, R5 is isopentyl. In some embodiments, R5 is isohexyl. In some embodiments, R5 is sec-butyl. In some embodiments, R5 is sec-pentyl. In some embodiments, R5 is sec-hexyl. In some embodiments, R5 is tert-butyl.

[0275] In some embodiments, R5 is C 2~6 It is an alkenyl. In some embodiments, R5 is a C2 alkenyl. In some embodiments, R5 is a C3 alkenyl. In some embodiments, R5 is a C4 alkenyl. In some embodiments, R5 is a C5 alkenyl. In some embodiments, R5 is a C6 alkenyl.

[0276] In some embodiments, R5 is C 2~6 It is an alkynyl. In some embodiments, R5 is a C2 alkynyl. In some embodiments, R5 is a C3 alkynyl. In some embodiments, R5 is a C4 alkynyl. In some embodiments, R5 is a C5 alkynyl. In some embodiments, R5 is a C6 alkynyl.

[0277] In some embodiments, R5 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0278] In some embodiments, R5 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0279] In some embodiments, R5 is C 3~10 A cycloalkyl or a 3-13 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with one or more R7 atoms.

[0280] In some embodiments, R5 is C 3~10 It is a cycloalkyl or a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0281] In some embodiments, R5 may be replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0282] In some embodiments, R5 is a C3 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C4 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C5 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C6 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C7 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C8 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C9 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R5 is a C 10 It is a cycloalkyl group.

[0283] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R5 is a C9-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl group. In some embodiments, R5 may be substituted with one or more R7s C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 may be substituted with one or more R7s C9-C10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 may be substituted with one or more R7s C8~C 10 It is a polycyclic cycloalkyl group.

[0284] In some embodiments, R5 is replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0285] In some embodiments, R5 is a C3 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C4 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C5 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C6 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C7 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C8 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C9 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C6 cycloalkyl group substituted with one or more R7 groups. 10 It is a cycloalkyl group.

[0286] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R5 is a C9-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl. In some embodiments, R5 is substituted with one or more R7s, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 is substituted with one or more R7s, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 is a C8-C substituted with one or more R7s.10 It is a polycyclic cycloalkyl group.

[0287] In some embodiments, R5 is replaced by a single R7. 3~10 It is a cycloalkyl group.

[0288] In some embodiments, R5 is a C3 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C4 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C5 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C6 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C7 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C8 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C9 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C6 cycloalkyl group substituted with one R7. 10 It is a cycloalkyl group.

[0289] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group substituted with one R7. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one R7. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. In some embodiments, R5 is a C9-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. 10 It is a bicyclic cycloalkyl group. In some embodiments, R5 is substituted with one R7, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 is substituted with one R7, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 is a C8-C substituted with one R7. 10 It is a polycyclic cycloalkyl group.

[0290] In some embodiments, R5 is C 3~10 It is a cycloalkyl group.

[0291] In some embodiments, R5 is a C3 cycloalkyl group. In some embodiments, R5 is a C4 cycloalkyl group. In some embodiments, R5 is a C5 cycloalkyl group. In some embodiments, R5 is a C6 cycloalkyl group. In some embodiments, R5 is a C7 cycloalkyl group. In some embodiments, R5 is a C8 cycloalkyl group. In some embodiments, R5 is a C9 cycloalkyl group. In some embodiments, R5 is a C 10 It is a cycloalkyl group.

[0292] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R5 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R5 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R5 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R5 is C8~C 10 It is a polycyclic cycloalkyl group.

[0293] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0294] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0295] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0296] In some embodiments, R5 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0297] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0298] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0299] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0300] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0301] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heterocycline comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0302] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7s.

[0303] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0304] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0305] In some embodiments, R5 is C 6~10 A 5-13 member heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl may be substituted with one or more R7 atoms.

[0306] In some embodiments, R5 is C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0307] In some embodiments, R5 may be replaced by one or more R7s. 6~10 It is Ariel.

[0308] In some embodiments, R5 may be replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound which may be substituted with one or more R7s.

[0309] In some embodiments, R5 is replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound substituted with one or more R7s.

[0310] In some embodiments, R5 is replaced by a single R7. 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound substituted with one R7.

[0311] In some embodiments, R5 is C 6~10 It is Ariel.

[0312] In some embodiments, R5 is C 6~8 It is an aryl compound. In some embodiments, R5 is a phenyl compound.

[0313] In some embodiments, R5 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0314] In some embodiments, R5 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0315] In some embodiments, R5 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0316] In some embodiments, R5 is a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0317] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0318] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0319] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered bicyclic heteroaryl substituted with one R7, containing 1 to 4 heteroatoms selected from N, O, and S.

[0320] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0321] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0322] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0323] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0324] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0325] In some embodiments, R5 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5- to 13-membered heteroaryl or -C(O)R7 containing 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0326] In some embodiments, R5 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0327] In some embodiments, R5 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms.

[0328] In some embodiments, R5 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0329] In some embodiments, R5 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0330] In some embodiments, R5 is phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0331] In some embodiments, R5 is pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0332] In some embodiments, R5 is a pyridine, pyrimidine, or indazole.

[0333] In some embodiments, R5 is indazole.

[0334] In some embodiments, R5 is tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0335] In some embodiments, R5 is a tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0336] In some embodiments, R5 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0337] In some embodiments, R5 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, or benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole.

[0338] In some embodiments, R5 is 9H-carbazole.

[0339] In some embodiments, R6 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0340] In some embodiments, R6 is H, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0341] In some embodiments, R6 is H.

[0342] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 member heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0343] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0344] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0345] In some embodiments, R6 may be replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R6 is methyl which may be substituted with one or more R7s. In some embodiments, R6 is ethyl which may be substituted with one or more R7s. In some embodiments, R6 is propyl which may be substituted with one or more R7s. In some embodiments, R6 is butyl which may be substituted with one or more R7s. In some embodiments, R6 is pentyl which may be substituted with one or more R7s. In some embodiments, R6 is hexyl which may be substituted with one or more R7s. In some embodiments, R6 is isopropyl which may be substituted with one or more R7s. In some embodiments, R6 is isobutyl which may be substituted with one or more R7s. In some embodiments, R6 is isopentyl which may be substituted with one or more R7s. In some embodiments, R6 is isohexyl which may be substituted with one or more R7s. In some embodiments, R6 is secbutyl which may be substituted with one or more R7s. In some embodiments, R6 is sec-pentyl which may be substituted with one or more R7 atoms. In some embodiments, R6 is sec-hexyl which may be substituted with one or more R7 atoms. In some embodiments, R6 is tert-butyl which may be substituted with one or more R7 atoms.

[0346] In some embodiments, R6 may be replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C3 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C4 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C5 alkenyl which may be substituted with one or more R7s. In some embodiments, R6 is a C6 alkenyl which may be substituted with one or more R7s.

[0347] In some embodiments, R6 may be replaced by one or more R7s. 2~6 It is an alkynyl. In some embodiments, R6 is a C2 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C3 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C4 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C5 alkynyl which may be substituted with one or more R7s. In some embodiments, R6 is a C6 alkynyl which may be substituted with one or more R7s.

[0348] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 The alkyl, alkenyl, or alkynyl is substituted with one or more R7 groups.

[0349] In some embodiments, R6 is replaced by one or more R7s. 1~6It is alkyl. In some embodiments, R6 is methyl substituted with one or more R7s. In some embodiments, R6 is ethyl substituted with one or more R7s. In some embodiments, R6 is propyl substituted with one or more R7s. In some embodiments, R6 is butyl substituted with one or more R7s. In some embodiments, R6 is pentyl substituted with one or more R7s. In some embodiments, R6 is hexyl substituted with one or more R7s. In some embodiments, R6 is isopropyl substituted with one or more R7s. In some embodiments, R6 is isobutyl substituted with one or more R7s. In some embodiments, R6 is isopentyl substituted with one or more R7s. In some embodiments, R6 is isohexyl substituted with one or more R7s. In some embodiments, R6 is secbutyl substituted with one or more R7s. In some embodiments, R6 is sec-pentyl substituted with one or more R7 atoms. In some embodiments, R6 is sec-hexyl substituted with one or more R7 atoms. In some embodiments, R6 is tert-butyl substituted with one or more R7 atoms.

[0350] In some embodiments, R6 is replaced by one or more R7s. 2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C3 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C4 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C5 alkenyl substituted with one or more R7s. In some embodiments, R6 is a C6 alkenyl substituted with one or more R7s.

[0351] In some embodiments, R6 is replaced by one or more R7s. 2~6It is an alkynyl. In some embodiments, R6 is a C2 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C3 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C4 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C5 alkynyl substituted with one or more R7s. In some embodiments, R6 is a C6 alkynyl substituted with one or more R7s.

[0352] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is substituted with one R7.

[0353] In some embodiments, R6 is replaced by a single R7. 1~6 It is alkyl. In some embodiments, R6 is methyl substituted with one R7. In some embodiments, R6 is ethyl substituted with one R7. In some embodiments, R6 is propyl substituted with one R7. In some embodiments, R6 is butyl substituted with one R7. In some embodiments, R6 is pentyl substituted with one R7. In some embodiments, R6 is hexyl substituted with one R7. In some embodiments, R6 is isopropyl substituted with one R7. In some embodiments, R6 is isobutyl substituted with one R7. In some embodiments, R6 is isopentyl substituted with one R7. In some embodiments, R6 is isohexyl substituted with one R7. In some embodiments, R6 is secbutyl substituted with one R7. In some embodiments, R6 is secpentyl substituted with one R7. In some embodiments, R6 is sec hexyl substituted with one R7. In some embodiments, R6 is tert butyl substituted with one R7.

[0354] In some embodiments, R6 is replaced by a single R7.2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl substituted with one R7. In some embodiments, R6 is a C3 alkenyl substituted with one R7. In some embodiments, R6 is a C4 alkenyl substituted with one R7. In some embodiments, R6 is a C5 alkenyl substituted with one R7. In some embodiments, R6 is a C6 alkenyl substituted with one R7.

[0355] In some embodiments, R6 is replaced by a single R7. 2~6 It is an alkynyl. In some embodiments, R6 is a C2 alkynyl substituted with one R7. In some embodiments, R6 is a C3 alkynyl substituted with one R7. In some embodiments, R6 is a C4 alkynyl substituted with one R7. In some embodiments, R6 is a C5 alkynyl substituted with one R7. In some embodiments, R6 is a C6 alkynyl substituted with one R7.

[0356] In some embodiments, R6 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0357] In some embodiments, R6 is C 1~6 It is alkyl. In some embodiments, R6 is methyl. In some embodiments, R6 is ethyl. In some embodiments, R6 is propyl. In some embodiments, R6 is butyl. In some embodiments, R6 is pentyl. In some embodiments, R6 is hexyl. In some embodiments, R6 is isopropyl. In some embodiments, R6 is isobutyl. In some embodiments, R6 is isopentyl. In some embodiments, R6 is isohexyl. In some embodiments, R6 is sec-butyl. In some embodiments, R6 is sec-pentyl. In some embodiments, R6 is sec-hexyl. In some embodiments, R6 is tert-butyl.

[0358] In some embodiments, R6 is C 2~6 It is an alkenyl. In some embodiments, R6 is a C2 alkenyl. In some embodiments, R6 is a C3 alkenyl. In some embodiments, R6 is a C4 alkenyl. In some embodiments, R6 is a C5 alkenyl. In some embodiments, R6 is a C6 alkenyl.

[0359] In some embodiments, R6 is C 2~6 It is an alkynyl. In some embodiments, R6 is a C2 alkynyl. In some embodiments, R6 is a C3 alkynyl. In some embodiments, R6 is a C4 alkynyl. In some embodiments, R6 is a C5 alkynyl. In some embodiments, R6 is a C6 alkynyl.

[0360] In some embodiments, R6 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0361] In some embodiments, R6 is C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0362] In some embodiments, R6 is C 3~10 A cycloalkyl or a 3-13 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with one or more R7 atoms.

[0363] In some embodiments, R6 is C 3~10 It is a cycloalkyl or a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0364] In some embodiments, R6 may be replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0365] In some embodiments, R6 is a C3 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C4 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C5 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C6 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C7 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C8 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C9 cycloalkyl which may be substituted with one or more R7s. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0366] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R7 groups. In some embodiments, R6 is a C9-C7 monocyclic cycloalkyl group which may be substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl group. In some embodiments, R6 may be substituted with one or more R7s C9-C 10 It is a bicyclic saturated cycloalkyl group. In some embodiments, R6 may be substituted with one or more R7s C9-C10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 may be substituted with one or more R7s C8-C 10 It is a polycyclic cycloalkyl group.

[0367] In some embodiments, R6 is replaced by one or more R7s. 3~10 It is a cycloalkyl group.

[0368] In some embodiments, R6 is a C3 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C4 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C5 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C6 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C7 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C8 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C9 cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0369] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R7 groups. In some embodiments, R6 is a C9-C7 monocyclic cycloalkyl group substituted with one or more R7 groups. 10 It is a bicyclic cycloalkyl. In some embodiments, R6 is substituted with one or more R7s, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R6 is substituted with one or more R7s, C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 is a C8-C substituted with one or more R7s.10 It is a polycyclic cycloalkyl group.

[0370] In some embodiments, R6 is replaced by a single R7. 3~10 It is a cycloalkyl group.

[0371] In some embodiments, R6 is a C3 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C4 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C5 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C6 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C7 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C8 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C9 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0372] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group substituted with one R7. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one R7. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. In some embodiments, R6 is a C9-C7 monocyclic partially saturated cycloalkyl group substituted with one R7. 10 It is a bicyclic cycloalkyl group. In some embodiments, R6 is substituted with one R7, C9-C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R6 is substituted with one R7 C9-C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 is a C8-C substituted with one R7. 10 It is a polycyclic cycloalkyl group.

[0373] In some embodiments, R6 is C 3~10 It is a cycloalkyl group.

[0374] In some embodiments, R6 is a C3 cycloalkyl group. In some embodiments, R6 is a C4 cycloalkyl group. In some embodiments, R6 is a C5 cycloalkyl group. In some embodiments, R6 is a C6 cycloalkyl group. In some embodiments, R6 is a C7 cycloalkyl group. In some embodiments, R6 is a C8 cycloalkyl group. In some embodiments, R6 is a C9 cycloalkyl group. In some embodiments, R6 is a C 10 It is a cycloalkyl group.

[0375] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, R6 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R6 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R6 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R6 is C8~C 10 It is a polycyclic cycloalkyl group.

[0376] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0377] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0378] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0379] In some embodiments, R6 is a 3- to 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0380] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0381] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0382] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0383] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered bicyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0384] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0385] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7s.

[0386] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0387] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered polycyclic heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0388] In some embodiments, R6 is C 6~10 A 5-13 member heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl may be substituted with one or more R7 atoms.

[0389] In some embodiments, R6 is C 6~10 It is an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0390] In some embodiments, R6 may be replaced by one or more R7s. 6~10 It is Ariel.

[0391] In some embodiments, R6 may be replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound which may be substituted with one or more R7s.

[0392] In some embodiments, R6 is replaced by one or more R7s. 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound substituted with one or more R7s.

[0393] In some embodiments, R6 is replaced by a single R7. 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound substituted with one R7.

[0394] In some embodiments, R6 is C 6~10 It is Ariel.

[0395] In some embodiments, R6 is C 6~8 It is an aryl compound. In some embodiments, R6 is a phenyl compound.

[0396] In some embodiments, R6 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heteroaryl compound comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0397] In some embodiments, R6 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0398] In some embodiments, R6 is a 5- to 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0399] In some embodiments, R6 is a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 5-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 6-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0400] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0401] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered bicyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0402] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered bicyclic heteroaryl substituted with one R7, containing 1 to 4 heteroatoms selected from N, O, and S.

[0403] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered bicyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0404] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0405] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 9-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 10-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is an 11-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 12-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R6 is a 13-membered polycyclic heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0406] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one R7.

[0407] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered polycyclic heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0408] In some embodiments, R6 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5- to 13-membered heteroaryl or -C(O)R7 containing 1 to 4 heteroatoms selected from aryl, N, O, and S, where the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0409] In some embodiments, R6 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-13 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R7 atoms.

[0410] In some embodiments, R6 is H, C 1~6 Alkyl, C 3~10 Cycloalkyl, 3-13 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5- to 13-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with one or more R7 atoms.

[0411] In some embodiments, R6 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0412] In some embodiments, R6 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0413] In some embodiments, R6 is phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0414] In some embodiments, R6 is pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0415] In some embodiments, R6 is a pyridine, pyrimidine, or indazole.

[0416] In some embodiments, R6 is indazole.

[0417] In some embodiments, R6 is tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0418] In some embodiments, R6 is a tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0419] In some embodiments, R6 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0420] In some embodiments, R6 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, or benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole.

[0421] In some embodiments, R6 is 9H-carbazole.

[0422] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the heterocyclyl or heteroaryl may be substituted with one or more R7s.

[0423] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0424] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0425] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0426] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0427] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0428] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0429] In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0430] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7s.

[0431] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0432] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0433] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0434] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with one R7.

[0435] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7.

[0436] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 4-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0437] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a four-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an eight-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a nine-membered heterocycline containing one to four heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0438] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0439] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a five-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a six-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a seven-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an eight-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a nine-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a ten-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, which may be substituted with one or more R7 atoms.

[0440] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 5-10 membered heteroaryl ion comprising 1-4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0441] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heteroaryl ion comprising 1 to 4 heteroatoms selected from N, O, and S, which are substituted with one or more R7 atoms.

[0442] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a nine-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, each substituted with one R7. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a ten-membered heteroaryl compound containing one to four heteroatoms selected from N, O, and S, each substituted with one R7.

[0443] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a 5-10 membered heteroaryl aryl composing 1-4 heteroatoms selected from N, O, and S.

[0444] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atom to which they are bonded, form a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0445] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a piperidine which may be substituted with one or more R7 atoms.

[0446] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a piperidine substituted with one or more R7 atoms.

[0447] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a piperidine substituted with one R7.

[0448] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a piperidine.

[0449] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroquinoline which may be substituted with one or more R7 atoms.

[0450] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroquinoline substituted with one or more R7 atoms.

[0451] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroquinoline substituted with one R7.

[0452] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form tetrahydroquinoline.

[0453] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroisoquinoline which may be substituted with one or more R7 atoms.

[0454] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroisoquinoline substituted with one or more R7 atoms.

[0455] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroisoquinoline substituted with one R7.

[0456] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form tetrahydroisoquinoline.

[0457] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroimidazopyrazine which may be substituted with one or more R7 atoms.

[0458] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroimidazopyrazine substituted with one or more R7 atoms.

[0459] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydroimidazopyrazine substituted with one R7.

[0460] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form tetrahydroimidazopyrazine.

[0461] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form a tetrahydronaphthiridine which may be substituted with one or more R7 atoms.

[0462] In some embodiments, R5 and R6, together with the atoms to which they are bonded, form tetrahydronaphthiridines substituted with one or more R7 atoms.

[0463] In some embodiments, R5 and R6, together with the atom to which they are bonded, form a tetrahydronaphthiridine substituted with one R7.

[0464] In some embodiments, R5 and R6, together with the atom to which they are bonded, form tetrahydronaphthiridine.

[0465] In some embodiments, each R7 is independently oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2)t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may be replaced with .

[0466] In some embodiments, each R7 is independently oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 1~6 Alkoxy, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-O-(CH2) t -R8, -NH-(CH2) t -R8, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0467] In some embodiments, R7 is oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, -O-(CH2) t -R8, or -NH-(CH2) t -R8

[0468] In some embodiments, R7 is an oxo, halogen, -OH, -NH2, or -CN.

[0469] In some embodiments, R7 is an oxo.

[0470] In some embodiments, R7 is a halogen. In some embodiments, R7 is F, Cl, Br, or I. In some embodiments, R7 is F, Cl, or Br. In some embodiments, R7 is F. In some embodiments, R7 is Cl. In some embodiments, R7 is Br. In some embodiments, R7 is I.

[0471] In some embodiments, R7 is -OH. In some embodiments, R7 is -NH2. In some embodiments, R7 is -CN.

[0472] In some embodiments, R7 is -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 )2, -O-(CH2) t -R8, or -NH-(CH2) t -R8

[0473] In some embodiments, R7 is -C(O)R 10 In some aspects, R7 is -C(O)OR 10 In some embodiments, R7 is -C(O)N(R 10 )2. In some embodiments, R7 is -O-(CH2) t -R8. In some embodiments, R7 is -NH-(CH2) t -R8

[0474] In some embodiments, R7 is C 1~6 Alkoxy, -NH(C 1~6 Alkyl), or -N(C 1~6 It is alkyl(2).

[0475] In some embodiments, R7 is one or more R 10 Even if replaced by C 1~6 It is an alkoxy.

[0476] In some embodiments, R7 is one or more R 10 C replaced by 1~6 It is an alkoxy.

[0477] In some embodiments, R7 is one R 10 C replaced by 1~6 It is an alkoxy. In some embodiments, R7 is two R 10 C replaced by 1~6 It is an alkoxy.

[0478] In some embodiments, R7 is C 1~6 It is an alkoxy. In some embodiments, R7 is methoxy. In some embodiments, R7 is ethoxy. In some embodiments, R7 is propoxy. In some embodiments, R7 is butoxy. In some embodiments, R7 is pentoxy. In some embodiments, R7 is hexoxy. In some embodiments, R7 is isopropoxy. In some embodiments, R7 is isobutoxy. In some embodiments, R7 is isopentoxy. In some embodiments, R7 is isohexoxy. In some embodiments, R7 is secbutoxy. In some embodiments, R7 is secpentoxy. In some embodiments, R7 is sechexoxy. In some embodiments, R7 is tertbutoxy.

[0479] In some embodiments, R7 is -NH(C 1~6 Alkyl) or -N(C 1~6 It is alkyl)2. In some embodiments, R7 is -NH(C 1~6 It is alkyl. In some embodiments, R7 is -N(C 1~6 It is alkyl(2).

[0480] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may be replaced with .

[0481] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0482] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more R 10 It may be replaced with .

[0483] In some embodiments, R7 is one or more R 10 Even if replaced by C 1~3 It is alkyl. In some embodiments, R7 is one or more R 10 It is a methyl that may be substituted with. In some embodiments, R7 is one or more R 10 It is ethyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a propyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is an isopropyl that may be substituted with [another compound].

[0484] In some embodiments, R7 is one or more R 10 Even if replaced by C 2~6 It is an alkenil. In some embodiments, R7 is one or more R 10 It is a C2 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C5 alkenyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C6 alkenyl which may be substituted with [another compound].

[0485] In some embodiments, R7 is one or more R 10 Even if replaced by C 2~6 It is an alkynyl. In some embodiments, R7 is one or more R 10 It is a C2 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C5 alkynyl which may be substituted with. In some embodiments, R7 is one or more R 10 It is a C6 alkynyl which may be substituted with [another compound].

[0486] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more R 10 It has been replaced with.

[0487] In some embodiments, R7 is one or more R10 C replaced by 1~3 It is alkyl. In some embodiments, R7 is one or more R 10 It is a methyl substituted with. In some embodiments, R7 is one or more R 10 It is ethyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a propyl substituted with R7. In some embodiments, R7 is one or more R 10 It is isopropyl substituted with [the specified compound].

[0488] In some embodiments, R7 is one or more R 10 C replaced by 2~6 It is an alkenil. In some embodiments, R7 is one or more R 10 It is a C2 alkenyl substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkenyl substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkenyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C5 alkenyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C6 alkenyl substituted with [the specified compound].

[0489] In some embodiments, R7 is one or more R 10 C replaced by 2~6 It is an alkynyl. In some embodiments, R7 is one or more R 10 It is a C2 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C3 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C4 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C5 alkynyl substituted with. In some embodiments, R7 is one or more R 10 It is a C6 alkynyl substituted with [the specified compound].

[0490] In some embodiments, R7 is C 1~3 Alkyl, C 2~6 Alkenyl, or C 2~6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one R 10 It has been replaced with.

[0491] In some embodiments, R7 is one R 10 C replaced by 1~3 It is alkyl. In some embodiments, R7 is one R 10 It is a methyl substituted with. In some embodiments, R7 is one R 10 It is ethyl substituted with. In some embodiments, R7 is one R 10 It is a propyl substituted with R. In some embodiments, R7 is one R 10 It is isopropyl substituted with [the specified compound].

[0492] In some embodiments, R7 is one R 10 C replaced by 2~6 It is an alkenil. In some embodiments, R7 is one R 10 It is a C2 alkenyl substituted with. In some embodiments, R7 is one R 10 It is a C3 alkenyl substituted with. In some embodiments, R7 is one R 10 It is a C4 alkenyl substituted with R. In some embodiments, R7 is one R 10 It is a C5 alkenyl substituted with. In some embodiments, R7 is one R 10 It is a C6 alkenyl substituted with [the specified compound].

[0493] In some embodiments, R7 is one R 10 C replaced by 2~6 It is an alkynyl. In some embodiments, R7 is one R 10 It is a C2 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C3 alkynyl substituted with. In some embodiments, R7 is one R 10It is a C4 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C5 alkynyl substituted with. In some embodiments, R7 is one R 10 It is a C6 alkynyl substituted with [the specified compound].

[0494] In some embodiments, R7 is C 1~6 Alkyl, C 2~6 Alkenyl, or C 2~6 It is alkinyl.

[0495] In some embodiments, R7 is C 1~3 It is alkyl. In some embodiments, R7 is methyl. In some embodiments, R7 is ethyl. In some embodiments, R7 is propyl. In some embodiments, R7 is isopropyl.

[0496] In some embodiments, R7 is C 2~6 It is an alkenyl. In some embodiments, R7 is a C2 alkenyl. In some embodiments, R7 is a C3 alkenyl. In some embodiments, R7 is a C4 alkenyl. In some embodiments, R7 is a C5 alkenyl. In some embodiments, R7 is a C6 alkenyl.

[0497] In some embodiments, R7 is C 2~6 It is an alkynyl. In some embodiments, R7 is a C2 alkynyl. In some embodiments, R7 is a C3 alkynyl. In some embodiments, R7 is a C4 alkynyl. In some embodiments, R7 is a C5 alkynyl. In some embodiments, R7 is a C6 alkynyl.

[0498] In some embodiments, R7 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10A 5-10 membered heteroaryl containing an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl contains one or more R 10 It may be replaced with .

[0499] In some embodiments, R7 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0500] In some embodiments, R7 is C 3~10 A cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline contains 1 or more R 10 It may be replaced with .

[0501] In some embodiments, R7 is C 3~10 It is a cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0502] In some embodiments, R7 is one or more R 10 Even if replaced by C 3~10 It is a cycloalkyl group.

[0503] In some embodiments, R7 is one or more R 10 It is a C3 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C4 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C5 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10It is a C6 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C7 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C8 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C9 cycloalkyl which may be substituted with R7. In some embodiments, R7 is one or more R 10 Even if replaced by C 10 It is a cycloalkyl group.

[0504] In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic cycloalkyl that may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic saturated cycloalkyl that may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic partially saturated cycloalkyl that may be substituted with R7. In some embodiments, R7 is one or more R 10 C9~C may be replaced with 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C may be replaced with 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C may be replaced with 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C8~C may be replaced with 10 It is a polycyclic cycloalkyl group.

[0505] In some embodiments, R7 is one or more R 10 C replaced by 3~10 It is a cycloalkyl group.

[0506] In some embodiments, R7 is one or more R 10 It is a C3 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C4 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C5 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C6 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C7 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C8 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C9 cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 C replaced by 10 It is a cycloalkyl group.

[0507] In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic cycloalkyl substituted with R. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic saturated cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 It is a C3-C7 monocyclic partially saturated cycloalkyl substituted with R7. In some embodiments, R7 is one or more R 10 C9~C replaced by 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C replaced by 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C9~C replaced by 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is one or more R 10 C8~C replaced by 10 It is a polycyclic cycloalkyl group.

[0508] In some embodiments, R7 is one R 10 C replaced by 3~10 It is a cycloalkyl group.

[0509] In some embodiments, R7 is one R 10 It is a C3 cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C4 cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C5 cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C6 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 It is a C7 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 It is a C8 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 It is a C9 cycloalkyl substituted with R7. In some embodiments, R7 is one R 10 C replaced by 10 It is a cycloalkyl group.

[0510] In some embodiments, R7 is one R 10 It is a C3-C7 monocyclic cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C3-C7 monocyclic saturated cycloalkyl substituted with R. In some embodiments, R7 is one R 10 It is a C3-C7 monocyclic partially saturated cycloalkyl substituted with R. In some embodiments, R7 is one R 10 C9~C replaced by 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is one R 10 C9~C replaced by 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is one R 10 C9~C replaced by 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is one R 10 C8~C replaced by10 It is a polycyclic cycloalkyl group.

[0511] In some embodiments, R7 is C 3~10 It is a cycloalkyl group.

[0512] In some embodiments, R7 is a C3 cycloalkyl group. In some embodiments, R7 is a C4 cycloalkyl group. In some embodiments, R7 is a C5 cycloalkyl group. In some embodiments, R7 is a C6 cycloalkyl group. In some embodiments, R7 is a C7 cycloalkyl group. In some embodiments, R7 is a C8 cycloalkyl group. In some embodiments, R7 is a C9 cycloalkyl group. In some embodiments, R7 is a C 10 It is a cycloalkyl group.

[0513] In some embodiments, R7 is a C3-C7 monocyclic cycloalkyl. In some embodiments, R7 is a C3-C7 monocyclic saturated cycloalkyl. In some embodiments, R7 is a C3-C7 monocyclic partially saturated cycloalkyl. In some embodiments, R7 is a C9-C 10 It is a bicyclic cycloalkyl. In some embodiments, R7 is C9~C 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R7 is C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R7 is C8~C 10 It is a polycyclic cycloalkyl group.

[0514] In some embodiments, R7 is one or more R 10 A 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R7s. 10 A three-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10A four-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a five-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a six-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R7s. 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A nine-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with .

[0515] In some embodiments, R7 is one or more R 10 It is a 3- to 10-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a three-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a four-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a five-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10It is a six-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0516] In some embodiments, R7 is one R 10 It is a 3- to 10-membered heterocycline containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a three-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10 It is a four-membered heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10 It is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R 10 It is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R. In some embodiments, R7 is 1 R 10 It is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one R10 It is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0517] In some embodiments, R7 is a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 3-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 4-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 5-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 6-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 7-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is an 8-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 9-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S.

[0518] In some embodiments, R7 is C 6~10 An aryl or 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl contains one or more R 10 It may be replaced with .

[0519] In some embodiments, R7 is C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0520] In some embodiments, R7 is one or more R 10 Even if replaced by C 6~10 It is Ariel.

[0521] In some embodiments, R7 is one or more R 10 Even if replaced by C 6~8 It is an arrow. In some embodiments, R7 is one or more R 10 It is a phenyl compound that may be substituted with [another compound].

[0522] In some embodiments, R7 is one or more R 10 C replaced by 6~8 It is an arrow. In some embodiments, R7 is one or more R 10 It is a phenyl compound substituted with [a specific compound].

[0523] In some embodiments, R7 is one R 10 C replaced by 6~8 It is an arrow. In some embodiments, R7 is one R 10 It is a phenyl compound substituted with [a specific compound].

[0524] In some embodiments, R7 is C 6~10 It is Ariel.

[0525] In some embodiments, R7 is C 6~8 It is an aryl compound. In some embodiments, R7 is a phenyl compound.

[0526] In some embodiments, R7 is one or more R 10 A 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A five-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10A six-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A 7-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is an 8-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 A nine-membered heteroaryl comprising 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with R7. In some embodiments, R7 is one or more R 10 It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which may be substituted with other elements.

[0527] In some embodiments, R7 is one or more R 10 It is a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is one or more R 10 It is a five-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is a six-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is a 7-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is an 8-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10 It is a 9-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one or more R 10It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0528] In some embodiments, R7 is one R 10 It is a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, which are substituted with R7. In some embodiments, R7 is 1 R 10 It is a 5-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 6-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 7-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is 1 R 10 It is an 8-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 9-membered heteroaryl substituted with 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is one R 10 It is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S, which are substituted with [a specific component].

[0529] In some embodiments, R7 is a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 5-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 6-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 7-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is an 8-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 9-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from N, O, and S.

[0530] In some embodiments, R7 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0531] In some embodiments, R7 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0532] In some embodiments, R7 is phenyl, pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0533] In some embodiments, R7 is pyridine, pyrimidine, tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0534] In some embodiments, R7 is a pyridine or pyrimidine.

[0535] In some embodiments, R7 is tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0536] In some embodiments, R7 is a tetrazole, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0537] In some embodiments, R7 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0538] In some embodiments, R7 is 1,3-dihydro-2H-benzo[d]imidazole-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxin, or benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole.

[0539] In some embodiments, R7 is 9H-carbazole.

[0540] In some embodiments, R7 is oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , C 1~6 Alkyl, C 2~6 Alkinyl, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl comprises one or more R 10 It may be replaced with .

[0541] In some embodiments, R7 is oxo, halogen, -OH, -NH2, -CN, -C(O)R 10 , C 1~6 Alkyl, C 2~6 Alkinyl, -O-(CH2) t -R8, C 6~10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, aryl, or heteroaryl comprises one or more R 10 It has been replaced with.

[0542] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms.

[0543] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 Alkyl), C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0544] In some embodiments, R8 is -OH, C1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, -SH, or -S(C 1~6 The alkyl group is wherein the alkoxy or alkyl group may be substituted with one or more R9 groups.

[0545] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, -SH, or -S(C 1~6 The alkyl group is, where the alkoxy or alkyl group is substituted with one or more R9 atoms.

[0546] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, -SH, or -S(C 1~6 The alkyl group is, where the alkoxy or alkyl group is substituted with one R9.

[0547] In some embodiments, R8 may be replaced by one or more R9s. 1~6 It is an alkoxy.

[0548] In some embodiments, R8 is C 1~6 It is an alkoxy-OH group, where the alkoxy may be substituted with one or more R9 groups.

[0549] In some embodiments, R8 is replaced by one or more R9s. 1~6 It is an alkoxy.

[0550] In some embodiments, R8 is C 1~6It is an alkoxy-OH group, where the alkoxy is substituted with one or more R9 groups.

[0551] In some embodiments, R8 is replaced by a single R9. 1~6 It is an alkoxy.

[0552] In some embodiments, R8 is C 1~6 It is an alkoxy-OH group, where the alkoxy is substituted with one R9 group.

[0553] In some embodiments, R8 is -NH(C 1~6 The alkyl group is an alkyl group, where the alkyl group may be substituted with one or more R9 groups.

[0554] In some embodiments, R8 is -N(C 1~6 The alkyl group is R92, where the alkyl group may be substituted with one or more R9 groups.

[0555] In some embodiments, R8 is -NH(C 1~6 The alkyl group is substituted with one or more R9 atoms.

[0556] In some embodiments, R8 is -N(C 1~6 The alkyl group is R92, where the alkyl group is substituted with one or more R9 atoms.

[0557] In some embodiments, R8 is -NH(C 1~6 It is an alkyl group, where the alkyl group is substituted with one R9.

[0558] In some embodiments, R8 is -N(C 1~6 It is alkyl)2, where the alkyl is substituted with one R9.

[0559] In some embodiments, R8 is -S(C 1~6 The alkyl group is R92, where the alkyl group may be substituted with one or more R9 groups.

[0560] In some embodiments, R8 is -S(C 1~6 The alkyl group is R92, where the alkyl group is substituted with one or more R9 atoms.

[0561] In some embodiments, R8 is -S(C 1~6 It is alkyl)2, where the alkyl is substituted with one R9.

[0562] In some embodiments, R8 is -OH, C 1~6 Alkoxy, C 1~6 Alkoxy-OH, -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2,-SH,-S(C 1~6 It is alkyl.

[0563] In some embodiments, R8 is -OH, C 1~6 Alkoxy, or C 1~6 It is an alkoxy-OH group.

[0564] In some embodiments, R8 is -OH.

[0565] In some embodiments, R8 is C 1~6 It is an alkoxy. In some embodiments, R8 is methoxy. In some embodiments, R8 is ethoxy. In some embodiments, R8 is propoxy. In some embodiments, R8 is butoxy. In some embodiments, R8 is pentoxy. In some embodiments, R8 is hexoxy. In some embodiments, R8 is isopropoxy. In some embodiments, R8 is isobutoxy. In some embodiments, R8 is isopentoxy. In some embodiments, R8 is isohexoxy. In some embodiments, R8 is secbutoxy. In some embodiments, R8 is secpentoxy. In some embodiments, R8 is sechexoxy. In some embodiments, R8 is tertbutoxy.

[0566] In some embodiments, R8 is C1~6 It is an alkoxy-OH group. In some embodiments, R8 is a methoxy-OH group. In some embodiments, R8 is an ethoxy-OH group. In some embodiments, R8 is a propoxy-OH group. In some embodiments, R8 is a butoxy-OH group. In some embodiments, R8 is a pentoxy-OH group. In some embodiments, R8 is a hexoxy-OH group. In some embodiments, R8 is an isopropoxy-OH group. In some embodiments, R8 is an isobutoxy-OH group. In some embodiments, R8 is an isopentoxy-OH group. In some embodiments, R8 is an isohexoxy-OH group. In some embodiments, R8 is a sec-butoxy-OH group. In some embodiments, R8 is a sec-pentoxy-OH group. In some embodiments, R8 is a sec-hexoxy-OH group. In some embodiments, R8 is a tert-butoxy-OH group.

[0567] In some embodiments, R8 is -NH2, -NH(C 1~6 Alkyl), or -N(C 1~6 It is alkyl(2).

[0568] In some embodiments, R8 is -NH2.

[0569] In some embodiments, R8 is -NH(C 1~6It is alkyl. In some embodiments, R8 is -NH (methyl). In some embodiments, R8 is -NH (ethyl). In some embodiments, R8 is -NH (propyl). In some embodiments, R8 is -NH (butyl). In some embodiments, R8 is -NH (pentyl). In some embodiments, R8 is -NH (hexyl). In some embodiments, R8 is -NH (isopropyl). In some embodiments, R8 is -NH (isobutyl). In some embodiments, R8 is -NH (isopentyl). In some embodiments, R8 is -NH (isohexyl). In some embodiments, R8 is -NH (sec-butyl). In some embodiments, R8 is -NH (sec-pentyl). In some embodiments, R8 is -NH (sec-hexyl). In some embodiments, R8 is -NH (tert-butyl).

[0570] In some embodiments, R8 is -N(C 1~6 R8 is alkyl)2. In some embodiments, R8 is -N(methyl)2. In some embodiments, R8 is -N(ethyl)2. In some embodiments, R8 is -N(propyl)2. In some embodiments, R8 is -N(butyl)2. In some embodiments, R8 is -N(pentyl)2. In some embodiments, R8 is -N(hexyl)2. In some embodiments, R8 is -N(isopropyl)2. In some embodiments, R8 is -N(isobutyl)2. In some embodiments, R8 is -N(isopentyl)2. In some embodiments, R8 is -N(isohexyl)2. In some embodiments, R8 is -N(secbutyl)2. In some embodiments, R8 is -N(secpentyl)2. In some embodiments, R8 is -N(sechexyl)2. In some embodiments, R8 is -N(tertbutyl)2.

[0571] In some embodiments, R8 is -SH or -S(C 1~6 It is alkyl.

[0572] In some embodiments, R8 is -SH.

[0573] In some embodiments, R8 is -S(C 1~6 It is alkyl(2).

[0574] In some embodiments, R8 is -S (methyl). In some embodiments, R8 is -S (ethyl). In some embodiments, R8 is -S (propyl). In some embodiments, R8 is -S (butyl). In some embodiments, R8 is -S (pentyl). In some embodiments, R8 is -S (hexyl). In some embodiments, R8 is -S (isopropyl). In some embodiments, R8 is -S (isobutyl). In some embodiments, R8 is -S (isopentyl). In some embodiments, R8 is -S (isohexyl). In some embodiments, R8 is -S (sec-butyl). In some embodiments, R8 is -S (sec-pentyl). In some embodiments, R8 is -S (sec-hexyl). In some embodiments, R8 is -S (tert-butyl).

[0575] In some embodiments, R8 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 A 5-10 membered heteroaryl comprising an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclyl, aryl, or heteroaryl may be substituted with one or more R9 atoms.

[0576] In some embodiments, R8 is C 3~10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6~10 It is an aryl or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S.

[0577] In some embodiments, R8 is C 3~10A cycloalkyl or a 3-10 membered heterocycline comprising 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocycline may be substituted with one or more R9 atoms.

[0578] In some embodiments, R8 is C 3~10 It is a cycloalkyl or a 3-10 membered heterocycline containing 1-4 heteroatoms selected from N, O, and S.

[0579] In some embodiments, R8 may be replaced by one or more R9s. 3~10 It is a cycloalkyl group.

[0580] In some embodiments, R8 is a C3 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C4 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C5 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C6 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C7 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C8 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C9 cycloalkyl which may be substituted with one or more R9s. In some embodiments, R8 is a C 10 It is a cycloalkyl group.

[0581] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group which may be substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group which may be substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R9s. In some embodiments, R8 is a C9-C7 monocyclic partially saturated cycloalkyl group which may be substituted with one or more R9s.10 It is a bicyclic cycloalkyl group. In some embodiments, R8 may be substituted with one or more R9s. 10 It is a bicyclic saturated cycloalkyl. In some embodiments, R8 may be substituted with one or more R9s C9~C 10 It is a bicyclic partially saturated cycloalkyl. In some embodiments, R8 may be substituted with one or more R9s C8~C 10 It is a polycyclic cycloalkyl group.

[0582] In some embodiments, R8 is replaced by one or more R9s. 3~10 It is a cycloalkyl group.

[0583] In some embodiments, R8 is a C3 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C4 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C5 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C6 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C7 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C8 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C9 cycloalkyl group substituted with one or more R9 groups. In some embodiments, R8 is a C3 cycloalkyl group substituted with one or more R9 groups. 10 It is a cycloalkyl group.

[0584] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R9s. In some embodiments, ...

Claims

1. Compounds of formula (IA), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, A is C 3～10 Cycloalkyl, 3- to 14-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 14-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y are each independently H, C 1～6 alkyl, C 2～6 alkenyl, C 2～6 alkynyl, C 1～6 alkoxy, halogen, -CN, -OH, -NH 2 , N, O, and a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 1 H, C 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -OC 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 , or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R 2 R 3 It is not H, but here the -OC 1～6 Alkyl, -OC 2～6 Alkenyl, or -OC 2～6 Alkinyl is C 6～10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 is independently, -(CH 2 ) u -(a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 aryl), where the heteroaryl or aryl may be substituted with one or more halogens, -CN, -OH, or -NH 2 ; Each R 10 is independently selected from halogen, -OH, -NH 2 , -CN, C 1～6 alkyl, C 2～6 alkenyl, C 2～6 alkynyl, C 1～6 haloalkyl, C 3～10 cycloalkyl, N, O, and S, and is a 3- to 10-member heterocyclyl containing 1 to 4 heteroatoms selected from N, O, and S, C 6～10 aryl, or a 5- to 10-member heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R 5 and R 6 However, together with the atoms they are bonded to, two R 7 Forms heterocyclines or heteroaryls substituted with both R 7 If it is -O-methyl, (a) R 2 and R 3 One of them is not -O-methyl; or, (b) R x or R y These are 5- to 10-membered heteroaryl compounds containing 1 to 4 heteroatoms selected from N, O, and S.

2. Compounds of formula (I), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, A is C 3～10 Cycloalkyl, 3- to 14-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 14-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, halogen, -CN, -OH, -NH 2 , a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 1 H, C 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -OC 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 , or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R 2 R 3 It is not H, but here the -OC 1～6 Alkyl, -OC 2～6 Alkenyl, or -OC 2～6 Alkinyl is C 6～10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 It is independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 A heteroaryl or aryl is one or more halogens, -CN, -OH, or -NH 2 It may also be replaced with; Each R 10 These are independently halogen, -OH, and -NH 2 ,-CN,C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It is a 5- to 10-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R 5 and R 6 However, together with the atoms they are bonded to, two R 7 When forming a heterocycline or heteroaryl substituted with one of the R's, 7 It is not -O-methyl.

3. Compounds of formula (I'), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, A is and; R x and R y These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, halogen, -CN, -OH, -NH 2 , a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 1 H, C 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -OC 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 , or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R 2 R 3 It is not H, but here the -OC 1～6 Alkyl, -OC 2～6 Alkenyl, or -OC 2～6 Alkinyl is C 6～10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 It is independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 A heteroaryl or aryl is one or more halogens, -CN, -OH, or -NH 2 It may also be replaced with; Each R 10 These are independently halogen, -OH, and -NH 2 ,-CN,C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It is a 5- to 10-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R 5 and R 6 However, together with the atoms they are bonded to, two R 7 When forming a heterocycline or heteroaryl substituted with one of the R's, 7 It is not -O-methyl.

4. Compounds of formula (II), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, R x H, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, halogen, -CN, -OH, -NH 2 , a 3- to 10-membered heterocycline containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 1 H, C 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and C, which are independent of each other. 2～6 Alkenil, C 2～6 Alkinyl, -OC 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkinyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 -C(O)NR 11 -S(O) 2 R 11 -C(O)NR 11 -S(O) 2 -OR 11 -C(O)NR 11 -S(O) 2 -N(R 11 ) 2 , or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R 2 R 3 It is not H, but here the -OC 1～6 Alkyl, -OC 2～6 Alkenyl, or -OC 2～6 Alkinyl is C 6～10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 5 and R 6 These are H and C, which are independent of each other. 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 It may be replaced with, or, R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 These are independently oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , -C(O)OR 10 ,-C(O)N(R 10 ) 2 , C 1～3 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Alkoxy, -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 ,-O-(CH 2 ) t -R 8 -NH-(CH 2 ) t -R 8 , C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 An aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 10 It may also be replaced with; R 8 is -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -NH(C 1～6 Alkyl), -N(C 1～6 Alkyl) 2 -SH, -S(C 1～6 Alkyl), C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 9 It may also be replaced with; Each R 9 It is independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 A heteroaryl or aryl is one or more halogens, -CN, -OH, or -NH 2 It may also be replaced with; Each R 10 These are independently halogen, -OH, and -NH 2 ,-CN,C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkinyl, C 1～6 Haloalkyl, C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It is a 5- to 10-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S; Each R 11 H and C are independent of each other. 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is an alkynyl, where the alkyl, alkenyl, or alkynyl is one or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 It may be substituted with an aryl, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the cycloalkyl, heterocyclyl, aryl, or heteroaryl is 1 or more C 3～10 Cycloalkyl, 3-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing 1-4 heteroatoms selected from aryl, N, O, and S, C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, oxo, halogen, -CN, -OH, or -NH 2 It may be replaced with, or, 2 R 11 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 It may also be replaced with; n, m, and p are each independently either 0 or 1; t is 1, 2, or 3; u is 0, 1, 2, or 3. Here, R 5 and R 6 However, together with the atoms they are bonded to, two R 7 When forming a heterocycline or heteroaryl substituted with one of the R's, 7 It is not -O-methyl.

5. Compounds of formula (IA'), or their pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers, or salts: During the ceremony, A is C 3～10 Cycloalkyl, 3- to 14-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 14-membered heteroaryl containing an aryl or 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclyl may be substituted with an oxo; R x and R y Each is independently a 5- to 10-membered heteroaryl compound containing 1 to 4 heteroatoms selected from H, or N, O, and S; R 1 H, C 1～6 Alkyl, C 2～6 Alkenyl, or C 2～6 It is alkinyl; R 2 and R 3 These are H and -OC, respectively, independently. 1～6 Alkyl, -OC 2～6 Alkenyl, -OC 2～6 Alkynyl, or -O- (a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S), where R 2 R 3 It is not H, but here the -OC 1～6 Alkyl, -OC 2～6 Alkenyl, or -OC 2～6 Alkinyl is C 6～10 It may also be substituted with an aryl or a 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S; R 5 and R 6 These, together with the atoms to which they are bonded, form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 It may also be replaced with; Each R 7 C 1～6 It is an alkoxy; n, m, and p are each independently either 0 or 1. Here (a) R 2 and R 3 One of them is not -O-methyl; or (b) R x or R y These are 5- to 10-membered heteroaryl compounds containing 1 to 4 heteroatoms selected from N, O, and S.

6. R x and R y H and C are independent of each other. 1～6 The compound according to any one of the claims, wherein it is alkyl or -OH.

7. R 1 is H or C 1～6 The compound according to any one of the above claims, wherein it is alkyl.

8. R 2 and R 3 Each of them operates independently, -OC 1～6 Alkyl, -C(O)R 11 , -C(O)OR 11 ,-C(O)N(R 11 ) 2 , or -C(O)NR 11 -S(O) 2 R 11 The compound according to any one of the above claims.

9. R 5 and R 6 H and C are independent of each other. 1～6 Alkyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5- to 13-membered heteroaryls containing 1 to 4 heteroatoms selected from aryl, N, O, and S, or -C(O)R 7 Here, the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 The compound according to any one of the claims, which may be substituted with

10. R 5 and R 6 H and C are independent of each other. 1～6 Alkyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 13-membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 The compound according to any one of the claims, which may be substituted with

11. R 5 and R 6 H and C are independent of each other. 1～6 Alkyl, C 3～10 Cycloalkyl, 3- to 13-membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, C 6～10 A 5- to 13-membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is one or more R 7 The compound according to any one of the claims, which is substituted with

12. R 5 and R 6 However, together with the atoms to which they are bonded, they form a 4-10 membered heterocyclyl containing 1-4 heteroatoms selected from N, O, and S, or a 5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, where the heterocyclyl or heteroaryl contains one or more R 7 The compound according to any one of the claims, which is substituted with

13. Each R 7 These independently form oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , C 1～3 Alkyl, C 2～6 Alkinyl, -O-(CH 2 ) t -R 8 , C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, alkoxy, aryl, or heteroaryl is one or more R 10 The compound according to any one of the claims, which may be substituted with

14. Each R 7 These independently form oxo, halogen, -OH, and -NH. 2 -CN, -C(O)R 10 , C 1～3 Alkyl, C 2～6 Alkinyl, C 1～6 Alkoxy, -O-(CH 2 ) t -R 8 , C 6～10 A 5-10 membered heteroaryl comprising an aryl, or 1-4 heteroatoms selected from N, O, and S, wherein the alkyl, alkynyl, alkoxy, aryl, or heteroaryl is one or more R 10 The compound according to any one of the claims, which is substituted with

15. R 8 -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -N(C 1～6 Alkyl) 2 , -S(C 1～6 A 3- to 10-membered heterocyclyl containing 1 to 4 heteroatoms selected from alkyl, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl contains one or more R 9 The compound according to any one of the claims, which may be substituted with

16. R 8 -OH, C 1～6 Alkoxy, C 1～6 Alkoxy-OH, -NH 2 , -N(C 1～6 Alkyl) 2 , -S(C 1～6 A 3- to 10-membered heterocyclyl containing 1 to 4 heteroatoms selected from alkyl, N, O, and S, or a 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclyl, or heteroaryl contains one or more R 9 The compound according to any one of the claims, which is substituted with

17. Each R 9 It became independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 The compound according to any one of the claims, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups.

18. Each R 9 It became independent, -(CH 2 ) u -(5-10 membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S) or -(CH 2 ) u -(C 6～10 The compound according to any one of the claims, wherein the heteroaryl or aryl is substituted with one or more halogens or -OH groups.

19. Each R 10 C 1～6 Alkyl, C 1～6 The compound according to any one of the claims, which is a haloalkyl or a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O, and S.

20. Each R 11 They became independent, H； One or more 3- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing aryl or 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1～6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1～6 The compound according to any one of the claims, which may be substituted with an alkyl group or an oxo group.

21. Each R 11 They became independent, H； One or more 3- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing aryl or 1-4 heteroatoms selected from N, O, and S Even if it is replaced with C 1～6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1～6 The compound according to any one of the claims, which is substituted with an alkyl group or an oxo group.

22. Each R 11 They became independent, H； One or more 3- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, C 6～10 5-10 membered heteroaryls containing aryl or 1-4 heteroatoms selected from N, O, and S Replaced with, C 1～6 Alkyl Here, the heterocyclyl, aryl, or heteroaryl is a 5-10 membered heteroaryl containing one or more heteroatoms selected from N, O, and S, C 1～6 The compound according to any one of the claims, which may be substituted with an alkyl group or an oxo group.

23. 2 R 11 However, together with the atoms to which they are bonded, One or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 4- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, which may be substituted. A compound according to any one of the above claims, which forms a compound.

24. 2 R 11 However, together with the atoms to which they are bonded, One or more C 1～6 Alkyl, C 2～6 Alkenil, C 2～6 Alkynyl, halogen, -CN, -OH, or -NH 2 4- to 10-membered heterocyclines containing 1-4 heteroatoms selected from N, O, and S, substituted with A compound according to any one of the above claims, which forms a compound.

25. The compound according to any one of the claims, wherein each n is 0.

26. The compound according to any one of the claims, wherein each n is 1.

27. The compound according to any one of the claims, wherein each m is 0.

28. The compound according to any one of the claims, wherein each m is 1.

29. The compound according to any one of the claims, wherein each p is 0.

30. The compound according to any one of the claims, wherein each p is 1.

31. R 2 R 3 The compound according to any one of the above claims, which is not H.

32. R 5 and R 6 However, together with the atoms they are bonded to, two R 7 When forming a heterocycline or heteroaryl substituted with one of the R's, 7 The compound according to any one of the claims, wherein is not -O-methyl.

33. Compounds of formula (Ia) or (Ib): or the compound according to any one of claims 1 to 3, which is a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

34. Compounds of formula (Ic), (Id), (Ie), or (If): or the compound according to any one of claims 1 to 3, which is a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

35. Compounds of formula (I-a') or (I-b'): or the compound according to any one of claims 1 to 3, which is a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

36. Compound of formula (II-a): or the compound according to any one of claims 1 to 4, which is a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

37. Compound of formula (II-a'): or the compound according to any one of claims 1 to 4, which is a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

38. A compound according to any one of claims 1 to 5, selected from Table 1.

39. A compound according to claim 1 or 5, selected from Table 2.

40. A pharmaceutical composition comprising a compound according to any one of claims 1 to 39, or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, and a pharmaceutically acceptable diluent or carrier.

41. A method for modulating P-glycoprotein activity and / or cytochrome P450 activity, comprising the step of contacting cells with an effective amount of a compound according to any one of claims 1 to 39 or a pharmaceutical composition according to claim 40.

42. A method for treating or preventing cancer in a subject in need, comprising the step of administering to the subject a therapeutically effective amount of a compound according to any one of claims 1 to 39 or a pharmaceutical composition according to claim 40.

43. A compound according to any one of claims 1 to 39 or a pharmaceutical composition according to claim 40 for use in modulating P-glycoprotein activity and / or cytochrome P450 activity.

44. A compound according to any one of claims 1 to 39 or a pharmaceutical composition according to claim 40 for use in treating or preventing any of the diseases or disorders disclosed herein.

45. Use of a compound according to any one of claims 1 to 39 or a pharmaceutical composition according to claim 40 in the manufacture of a pharmaceutical for modulating P-glycoprotein activity and / or cytochrome P450 activity.

46. Use of a compound according to any one of claims 1 to 39 or a pharmaceutical composition according to claim 40 in the manufacture of a medicament for treating or preventing a disease or disorder disclosed herein.

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