Ophthalmic devices

Abstract

We provide drug-eluting ophthalmic devices. [Solution] A drug-eluting ophthalmic device is provided, which comprises a body having a rear surface and a front surface, and the device is configured to remain on the conjunctiva of the eye due to the size of the body, the shape of the rear surface, and the shape of the front surface.

Claims

1. Rear and, Front and An ophthalmic device having a main body having, The device is configured to remain on the conjunctiva of the eye, based on the size of the main body, the shape of the rear surface, and the shape of the front surface. The device has elasticity with a Young's modulus of 0.3 to 1.5 MPa in a dry state. The aforementioned device.

2. The device according to claim 1, wherein when it remains on the conjunctiva of the eye, the posterior surface is adjacent to the conjunctiva of the eye, and the anterior surface is at least periodically adjacent to the inner surface of the eyelid.

3. The device according to claim 1, wherein the main body contains a therapeutic substance and is configured to dissolve the therapeutic substance into the eye when it remains on the conjunctiva of the eyeball.

4. The device according to claim 3, wherein the size of the main body is 2 to 8 mm.

5. The device according to claim 4, wherein the thickness of the main body is less than 400 microns.

6. The device according to claim 5, wherein the edge region of the main body, less than 0.5 mm from the edge of the main body, has a thickness of less than 50 microns.

7. The device according to claim 6, wherein the rear surface is concave.

8. The device according to claim 7, wherein the ratio of the radius of curvature of the posterior surface to the radius of curvature of the sclera of the eye is greater than 0.

8.

9. The device according to claim 7, wherein the radius of curvature of the rear surface is 9 to 11 mm.

10. The device according to claim 7, wherein the front surface is convex, and the radius of curvature of the front surface is smaller than the radius of curvature of the rear surface.

11. The device according to claim 7, configured to remain on the surface of the eyeball for at least 15 minutes.

12. The device according to claim 7, wherein the conjunctiva of the eyeball is a portion of the conjunctiva between the cornea and the fornix conjunctiva.

13. The device according to claim 7, wherein the conjunctiva of the eyeball is a portion of the conjunctiva that coincides with the tear meniscus.

14. The device according to claim 6, wherein the rear surface includes a mucosal adhesion material.

15. The device according to claim 6, wherein the front surface has a smooth surface and / or includes a lubricating material.

16. The aforementioned main body is a. Materials that break down in the eye, b. Either or both biodegradable materials and bioerosive materials, c. Two or more layers having different material properties, The device according to claim 7, comprising one or more of the following.

17. The device according to claim 6, wherein the rear surface includes one or more cavities and one or more protrusions.

18. a. The device comprises one or more electronic elements. b. The device is provided in a dry or semi-hydrated state. c. The device is hydrated on the surface of the eyeball. The device according to claim 7, which satisfies at least one of the following conditions.

19. The aforementioned main body is Hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose (CMC), polyvinyl alcohol (PVOH), polyethylene glycol (PEG), cellulose acetate (CA), polyvinyl alcohol-polyethylene glycol graft copolymer (Kollicoat), polyacrylic acid (e.g., Carbopol or Carbomer), hyaluronic acid, ethyl cellulose, triethyl citrate (TEC), glycerol, dextran, and combinations thereof. The device according to claim 1, comprising one or more of the following.

20. a. The device has one or more anchors configured to hold the device on the conjunctiva of the eye, b. The anchor has a sharp edge on the main body, c. The radius of curvature of the edge is less than 100 microns. d. The rear surface is rough. The device according to claim 1, which satisfies at least one of the following conditions.

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