Method, program, and apparatus for estimating glycation and oxidation

Abstract

Easily assess glycation or oxidation in the skin. [Solution] One embodiment of the present invention is a method for estimating glycation or oxidation in the skin, comprising estimating an index for glycation or an index for oxidation in the subject's skin by using the correlation between the measurement result by bioelectrical impedance method or the feature quantity of said measurement result and an index for glycation or an index for oxidation in the subject's skin.

Description

Technical Field

[0001] The present invention relates to a method for estimating glycation and oxidation, a program, and an apparatus.

Background Art

[0002] Conventionally, it is known to evaluate the skin by measuring the glycation state of the skin or the oxidation state of the skin.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, in order to measure the glycation state of the skin and the oxidation state of the skin, a specialized apparatus is required, and it has not been easy to measure the glycation state of the skin and the oxidation state of the skin.

[0005] Therefore, an object of the present invention is to easily evaluate glycation or oxidation in the skin.

Means for Solving the Problems

[0006] A method according to an embodiment of the present invention is a method for estimating glycation or oxidation in the skin, comprising estimating an index related to glycation in the skin of the subject or an index related to oxidation in the skin of the subject by using a correlation between a measurement result obtained by a bioelectrical impedance method or a feature amount of the measurement result and an index related to glycation in the skin of the subject or an index related to oxidation in the skin of the subject.

Effects of the Invention

[0007] According to the present invention, glycation or oxidation in the skin can be easily evaluated. [Brief explanation of the drawing]

[0008] [Figure 1] This is an example of the overall configuration related to one embodiment of the present invention. [Figure 2] This is a functional block diagram of a glycation / oxidation estimation device and a measuring device according to one embodiment of the present invention. [Figure 3] This is a functional block diagram of a glycation / oxidation estimation device according to one embodiment of the present invention. [Figure 4] This figure illustrates the correlation between advanced glycation end products (AGEs) and phase angle in one embodiment of the present invention. [Figure 5] This figure illustrates the correlation between skin yellowness and phase angle in one embodiment of the present invention. [Figure 6] This figure illustrates the correlation between melanin and phase angle in one embodiment of the present invention. [Figure 7] This is a sequence diagram of the glycation and oxidation estimation process related to one embodiment of the present invention. [Figure 8] This is a flowchart of the saccharification and oxidation estimation process related to one embodiment of the present invention. [Figure 9] This is a hardware configuration diagram of a glycation and oxidation estimation device according to one embodiment of the present invention. [Modes for carrying out the invention]

[0009] Embodiments of the present invention will be described below with reference to the drawings.

[0010] <Example of overall structure> Figure 1 shows an example of the overall configuration according to one embodiment of the present invention.

[0011] [Configuration Example 1] In Configuration Example 1, the measuring device 20 measures the subject 11 by the bioelectrical impedance method, and the glycation / oxidation estimation device 10 estimates an index related to glycation in the skin of the subject 11 or an index related to oxidation in the skin of the subject 11 from the measurement result by the bioelectrical impedance method or a feature amount of the measurement result. The glycation / oxidation estimation device 10 and the measuring device 20 can transmit and receive data to each other.

[0012] <<Glycation / Oxidation Estimation Device>> The glycation / oxidation estimation device 10 is an information processing device that estimates an index related to glycation in the skin of the subject 11 or an index related to oxidation in the skin of the subject 11. For example, the glycation / oxidation estimation device 10 is a personal computer, a tablet terminal, a smartphone, or the like.

[0013] <<Measuring Device>> The measuring device 20 is a device that performs measurement by the bioelectrical impedance method. The measuring device 20 includes a measurement unit 201 (details will be described later) that performs measurement by the bioelectrical impedance method. For example, the measuring device 20 is a body fat scale, a body composition analyzer, or the like.

[0014] [Configuration Example 2] In Configuration Example 2, the glycation / oxidation estimation device 10 measures the subject 11 by the bioelectrical impedance method, and estimates an index related to glycation in the skin of the subject 11 or an index related to oxidation in the skin of the subject 11 from the measurement result by the bioelectrical impedance method or a feature amount of the measurement result.

[0015] <<Glycation / Oxidation Estimation Device>> The glycation / oxidation estimation device 10 is an information processing device that performs measurements using the bioelectrical impedance method and estimates an index related to glycation in the skin of the subject 11 or an index related to oxidation in the skin of the subject 11. The glycation / oxidation estimation device 10 includes a measurement unit 201 (details will be described later) that performs measurements using the bioelectrical impedance method. For example, the glycation / oxidation estimation device 10 is a dedicated device having a function of performing measurements using the bioelectrical impedance method and a function of estimating an index related to glycation in the skin of the subject 11 or an index related to oxidation in the skin of the subject 11.

[0016] [Phase angle] Here, the measurement results obtained by the bioelectrical impedance method (sometimes also referred to as the bioimpedance method) and the characteristic quantity (phase angle) of the measurement results will be described.

[0017] The "measurement results obtained by the bioelectrical impedance method" is the value of the electrical resistance when a weak current flows through a person's body (for example, the arm, face). Specifically, the measurement results obtained by the bioelectrical impedance method are the values of reactance (the electrical resistance generated when the current passes through the cell membrane) and resistance (the electrical resistance generated when the current passes through the intracellular and extracellular water).

[0018] The "characteristic quantity of the measurement results obtained by the bioelectrical impedance method" is the phase angle calculated from the measurement results obtained by the bioelectrical impedance method. The phase angle indicates the degree of health of the cell membrane.

[0019] Specifically, the phase angle is the phase difference between reactance and resistance. The phase angle is calculated by the following formula. Formula: Phase angle = arctangent reactance / resistance × 180 / π

[0020] <Functional block> Hereinafter, referring to FIGS. 2 and 3, the functional blocks in the case of Example 1 and the functional blocks in the case of Example 2 will be described.

[0021] [Example 1] Figure 2 is a functional block diagram of a glycation / oxidation estimation device 10 and a measuring device 20 according to one embodiment of the present invention.

[0022] <<Saccharification and Oxidation Estimation Device>> The glycation / oxidation estimation device 10 may include an acquisition unit 100, a calculation unit 102, a glycation / oxidation index estimation unit 103, a metabolic state estimation unit 104, a screen generation unit 105, a screen output unit 106, and a correlation information storage unit 107. By executing a program, the glycation / oxidation estimation device 10 can function as the acquisition unit 100, the calculation unit 102, the glycation / oxidation index estimation unit 103, the metabolic state estimation unit 104, the screen generation unit 105, and the screen output unit 106.

[0023] The acquisition unit 100 acquires the phase angle value calculated by the measuring device 20, or the measurement results (specifically, the reactance value and the resistance value) from the measuring device 20.

[0024] The calculation unit 102 calculates the phase angle from the measurement results (specifically, the reactance value and the resistance value) obtained by the acquisition unit 100 from the measuring device 20 using the bioelectric impedance method.

[0025] The glycation / oxidation index estimation unit 103 estimates an index related to glycation or an index related to oxidation in the skin of subject 11 from the measurement results by bioelectrical impedance method or the characteristic quantities of said measurement results.

[0026] For example, the glycation / oxidation index estimation unit 103 estimates an index related to glycation or an index related to oxidation in the skin of the subject 11 from the phase angle value acquired by the acquisition unit 100 from the measuring device 20, or from the phase angle value calculated by the calculation unit 102.

[0027] For example, the glycation / oxidation index estimation unit 103 can estimate an index related to glycation in the skin or an index related to oxidation in the skin of subject 11 by using a trained model that outputs an index related to glycation in the skin or an index related to oxidation in the skin of subject 11 when measurement results by bioelectrical impedance method or features of said measurement results are input.

[0028] For example, the glycation / oxidation index estimation unit 103 can estimate an index related to glycation in the skin or an index related to oxidation in the skin of subject 11, according to predetermined rules for deriving such an index from the measurement results by bioelectrical impedance method or the characteristic quantities of said measurement results.

[0029] [Indicators related to glycation and indicators related to oxidation] Here, we will explain the indicators related to glycation and oxidation.

[0030] An indicator related to glycation can be any indicator that represents the state of glycation in the skin. For example, an indicator related to glycation is Advanced Glycation End Products (AGEs). For example, an indicator related to glycation is the degree of accumulation of AGEs. The more AGEs that have accumulated, the more glycated the skin is.

[0031] An indicator related to oxidation can be any indicator that represents the state of oxidation in the skin. For example, melanin can be an indicator related to oxidation. For example, an indicator related to oxidation is the degree of melanin accumulation (i.e., the concentration of melanin pigment (also called the melanin index)). The higher the concentration of melanin pigment, the more oxidized the skin is.

[0032] The metabolic state estimation unit 104 estimates the metabolic state of the subject 11's skin based on the estimation results of glycation-related indicators or oxidation-related indicators estimated by the glycation / oxidation indicator estimation unit 103. The metabolic state estimation unit 104 estimates that the higher the degree of glycation in the skin (i.e., the more glycated the skin is), the worse the skin's metabolism is, and that the higher the degree of oxidation in the skin (i.e., the more oxidized the skin is), the worse the skin's metabolism is.

[0033] For example, when the metabolic state estimation unit 104 receives the estimation results of an index related to glycation or an index related to oxidation, it can estimate the metabolic state of the subject's skin using a trained model that outputs the metabolic state of the skin.

[0034] For example, the metabolic state estimation unit 104 can estimate the metabolic state of the subject 11's skin according to predetermined rules for deriving the metabolic state of the skin from the estimation results of indicators related to glycation or oxidation.

[0035] The screen generation unit 105 generates a screen to display at least one of the following: the estimated results of the glycation / oxidation index estimation unit 103, which estimates an index related to glycation or an index related to oxidation; and the estimated results of the skin's metabolic state estimation unit 104, which estimates a metabolic state of the skin.

[0036] The screen output unit 106 outputs the screen generated by the screen generation unit 105 (for example, to display on the glycation / oxidation estimation device 10, or to display on a device other than the glycation / oxidation estimation device 10).

[0037] The correlation information storage unit 107 stores information on the correlation between the measurement results by the bioelectrical impedance method (specifically, the reactance value and the resistance value) or the characteristic quantity of said measurement results (specifically, the phase angle value) and an index related to glycation in the skin or an index related to oxidation in the skin.

[0038] For example, correlation information is a trained model that, when measurement results from bioelectrical impedance analysis (specifically, reactance and resistance values) or feature quantities of those measurement results (specifically, phase angle values) are input, outputs an index related to glycation in the skin or an index related to oxidation in the skin. For example, the trained model is a model that has been trained using backpropagation with a neural network.

[0039] For example, correlation information is a predetermined rule for deriving an index related to glycation or oxidation in the skin from measurement results by bioelectrical impedance analysis (specifically, the values ​​of reactance and resistance) or characteristic quantities of those measurement results (specifically, the values ​​of the phase angle).

[0040] <<Measuring device>> The measuring device 20 may include a measuring unit 201 and a calculation unit 202. The measuring device 20 can function as the measuring unit 201 and the calculation unit 202 by executing a program.

[0041] The measurement unit 201 performs measurements using the bioelectrical impedance method. Specifically, the measurement unit 201 measures reactance and resistance, which are the electrical resistance values ​​when a weak electric current is passed through the body (e.g., arm, face) of the subject 11.

[0042] The calculation unit 202 calculates the phase angle from the reactance and resistance values ​​measured by the measurement unit 201.

[0043] [Example 2] Figure 3 is a functional block diagram of a glycation / oxidation estimation device 10 according to one embodiment of the present invention. The glycation / oxidation estimation device 10 may include a measurement unit 101, a calculation unit 102, a glycation / oxidation index estimation unit 103, a metabolic state estimation unit 104, a screen generation unit 105, a screen output unit 106, and a correlation information storage unit 107. By executing a program, the glycation / oxidation estimation device 10 can function as the measurement unit 101, the calculation unit 102, the glycation / oxidation index estimation unit 103, the metabolic state estimation unit 104, the screen generation unit 105, and the screen output unit 106.

[0044] The measurement unit 101 performs measurements using the bioelectrical impedance method. Specifically, the measurement unit 101 measures reactance and resistance, which are the electrical resistance values ​​when a weak electric current is passed through the body (e.g., arm, face) of the subject 11.

[0045] The calculation unit 102 calculates the phase angle from the reactance and resistance values ​​measured by the measurement unit 101.

[0046] The glycation / oxidation index estimation unit 103 estimates an index related to glycation or an index related to oxidation in the skin of subject 11 from the measurement results by bioelectrical impedance method or the characteristic quantities of said measurement results. Details are the same as in Example 1, so the explanation is omitted.

[0047] The metabolic state estimation unit 104 is the same as in Example 1, so its description will be omitted.

[0048] The screen generation unit 105 is the same as in Example 1, so its description will be omitted.

[0049] The screen output unit 106 is the same as in Embodiment 1, so its description will be omitted.

[0050] The correlation information storage unit 107 is the same as in Example 1, so its description will be omitted.

[0051] The correlation between the state of skin glycation or oxidation used in this invention and the phase angle will be explained below with reference to Figures 4 to 6.

[0052] Figure 4 is a diagram illustrating the correlation between advanced glycation end products (AGEs) and phase angle according to one embodiment of the present invention. Figure 4 is a plot showing the degree of AGE accumulation and the phase angle values ​​in the arms of 24 healthy women aged 35 to 39 years. Let x = AGEs and y = phase angle. y = -0.5896x + 6.2765 R 2 =0.1991 That was the case. The correlation coefficient for Spearman's rank-sum correlation was -0.44 (p<0.05).

[0053] As shown in Figure 4, there was a correlation between advanced glycation end products (AGEs) and the phase angle in the same age group (35-39 years old). Therefore, in one embodiment of the present invention, it is possible to estimate advanced glycation end products (AGEs) from the phase angle while removing the influence of age. Specifically, the smaller the phase angle of subject 11, the higher the degree of accumulation of advanced glycation end products in subject 11's skin (the more glycation is occurring in the body).

[0054] Furthermore, glycation in the body can cause a yellowish dullness in the skin. As shown in Figure 5, the smaller the phase angle, the higher the degree of yellowness in the skin, indicating that a smaller phase angle corresponds to a higher degree of accumulation of advanced glycation end products (AGEs). Figure 5 is a plot showing the degree of yellowness in the skin and the phase angle values ​​of 24 healthy women aged 35 to 39. If x = phase angle and y = degree of yellowness in the skin, y = -2.1167x + 27.162 R 2 =0.1805 That was the case. The correlation coefficient for Spearman's rank-sum correlation was -0.37 (p=0.078).

[0055] Figure 6 is a diagram illustrating the correlation between melanin and phase angle according to one embodiment of the present invention. Figure 6 is a plot showing the degree of melanin accumulation (i.e., the concentration of melanin pigment (also called the melanin index)) and the phase angle values ​​of 24 healthy women aged 35 to 39 years. Let x = phase angle and y = melanin. y = -0.1519x + 1.5409 R 2 =0.1478 That was the case. The correlation coefficient for Spearman's rank-sum correlation was -0.36 (p=0.084).

[0056] As shown in Figure 6, there was a correlation between melanin and phase angle in the same age group (35-39 years old). Therefore, in one embodiment of the present invention, it is possible to estimate melanin from the phase angle while removing the influence of age. Specifically, the smaller the phase angle of subject 11, the higher the degree of melanin accumulation in subject 11's skin (the more oxidation in the body) can be estimated.

[0057] <Method> The following describes the methods for estimating saccharification and oxidation in Example 1 and Example 2, with reference to Figures 7 and 8.

[0058] [Example 1] Figure 7 is a sequence diagram of a saccharification and oxidation estimation process according to one embodiment of the present invention. Note that at least part of the process in Figure 7 (S11 to S17) may be performed by a person rather than by the devices.

[0059] In step 11 (S11), the measuring device 20 performs measurements using the bioelectrical impedance method. Specifically, the measuring device 20 measures reactance and resistance, which are the values ​​of electrical resistance when a weak electric current is passed through the body (e.g., arm, face) of the subject 11.

[0060] When the measuring device 20 calculates the phase angle, steps 12-1 and 13-1 are performed.

[0061] In step 12-1 (S12-1), the measuring device 20 calculates the phase angle from the reactance and resistance values ​​measured in S11.

[0062] In step 13-1 (S13-1), the measuring device 20 transmits the phase angle value calculated in S12-1 to the glycation / oxidation estimation device 10.

[0063] When the glycation / oxidation estimation device 10 calculates the phase angle, steps 12-2 and 13-2 are performed.

[0064] In step 12-2 (S12-2), the measuring device 20 transmits the reactance and resistance values ​​measured in S11 to the glycation / oxidation estimation device 10.

[0065] In step 13-2 (S13-2), the glycation / oxidation estimation device 10 calculates the phase angle from the reactance and resistance values ​​received in S12-2.

[0066] In step 14 (S14), the glycation / oxidation estimation device 10 estimates an index related to glycation or an index related to oxidation in the skin of subject 11 from the phase angle value received in S13-1 or the phase angle value calculated in S13-2.

[0067] In step 15 (S15), the glycation / oxidation estimation device 10 estimates the metabolic state of the subject's skin 11 based on the estimation results of the glycation-related indicators or oxidation-related indicators estimated in S14. Note that S15 may be omitted.

[0068] In step 16 (S16), the glycation / oxidation estimation device 10 generates a screen for displaying at least one of the estimation results of the glycation index or oxidation index estimated in S14 and the estimation results of the skin's metabolic state estimated in S15.

[0069] In step 17 (S17), the glycation / oxidation estimation device 10 outputs the screen generated in S16 (for example, displayed on the glycation / oxidation estimation device 10, or displayed on a device other than the glycation / oxidation estimation device 10).

[0070] [Example 2] Figure 8 is a flowchart of the saccharification and oxidation estimation process according to one embodiment of the present invention. Note that at least part of the process in Figure 8 (S101 to S106) may be performed by a person rather than by each device.

[0071] In step 101 (S101), the glycation / oxidation estimation device 10 performs measurements using the bioelectrical impedance method. Specifically, the glycation / oxidation estimation device 10 measures reactance and resistance, which are the electrical resistance values ​​when a weak electric current is passed through the body (e.g., arm, face) of the subject 11.

[0072] In step 102 (S102), the measuring device 20 calculates the phase angle from the reactance and resistance values ​​measured in S101.

[0073] In step 103 (S103), the glycation / oxidation estimation device 10 estimates an index related to glycation or an index related to oxidation in the skin of subject 11 from the phase angle value calculated in S102.

[0074] In step 104 (S104), the glycation / oxidation estimation device 10 estimates the metabolic state of the subject's skin 11 based on the estimation results of the glycation-related indicators or oxidation-related indicators estimated in S103. Note that S104 may be omitted.

[0075] In step 105 (S105), the glycation / oxidation estimation device 10 generates a screen for displaying at least one of the estimation results of the glycation index or oxidation index estimated in S103 and the estimation results of the skin's metabolic state estimated in S104.

[0076] In step 106 (S106), the glycation / oxidation estimation device 10 outputs the screen generated in S105 (for example, displayed on the glycation / oxidation estimation device 10, or displayed on a device other than the glycation / oxidation estimation device 10).

[0077] <Other Embodiments> In one embodiment of the present invention, the glycation / oxidation estimation device 10 can obtain measurement results (specifically, measurement values ​​of advanced glycation end products, melanin, etc.) of an index related to glycation or an index related to oxidation in the skin of subject 11, and estimate the phase angle calculated based on the measurement results by bioelectrical impedance analysis from the measurement results of the index related to glycation or an index related to oxidation in the skin of subject 11.

[0078] <Effects> Thus, in one embodiment of the present invention, the state of glycation and oxidation of the skin can be estimated and evaluated without measuring the state of glycation and oxidation of the skin. The state of glycation and oxidation of the skin represents skin function that cannot be determined by sensory evaluation, and conventionally it could not be evaluated without measurement. However, in the present invention, the state of glycation and oxidation of the skin can be easily estimated by utilizing the measurement results of bioelectrical impedance analysis methods such as body fat analyzers and body composition analyzers.

[0079] <Hardware Configuration> Figure 9 is a hardware configuration diagram of a saccharification / oxidation estimation device 10 according to one embodiment of the present invention. The saccharification / oxidation estimation device 10 may include a control unit 1001, a main memory unit 1002, an auxiliary memory unit 1003, an input unit 1004, an output unit 1005, and an interface unit 1006. Each of these will be described below.

[0080] The control unit 1001 is a processor (for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), etc.) that executes various programs installed in the auxiliary storage unit 1003.

[0081] The main memory unit 1002 includes non-volatile memory (ROM (Read Only Memory)) and volatile memory (RAM (Random Access Memory)). The ROM stores various programs, data, etc., necessary for the control unit 1001 to execute various programs installed in the auxiliary memory unit 1003. The RAM provides a work area that is expanded when the various programs installed in the auxiliary memory unit 1003 are executed by the control unit 1001.

[0082] The auxiliary storage unit 1003 is an auxiliary storage device that stores various programs and information used when various programs are executed.

[0083] The input unit 1004 is an input device in which the operator of the glycation / oxidation estimation device 10 inputs various instructions to the glycation / oxidation estimation device 10.

[0084] The output unit 1005 is an output device that outputs information such as the internal state of the saccharification / oxidation estimation device 10.

[0085] The interface unit 1006 is a communication device for connecting to a network and communicating with other devices.

[0086] Although embodiments of the present invention have been described in detail above, the present invention is not limited to the specific embodiments described above, and various modifications and changes are possible within the scope of the gist of the present invention as described in the claims. [Explanation of symbols]

[0087] 10. Glycation and Oxidation Estimation Device 11 Target Persons 20 Measuring devices 100 Acquisition Department 101 Measuring section 102 Calculation Unit 103 Glycation / Oxidation Index Estimation Department 104 Metabolic state estimation unit 105 Screen generation section 106 Screen output section 107 Correlation Information Storage Unit 201 Measuring section 202 Calculation Department 1001 Control Unit 1002 Main memory 1003 Auxiliary storage unit 1004 Input section 1005 Output section 1006 Interface section

Claims

1. A method for estimating glycation or oxidation in the skin, To estimate the index of glycation in the subject's skin or the index of oxidation in the subject's skin by using the correlation between the measurement results by bioelectrical impedance analysis or the characteristic quantities of said measurement results and the index of glycation in the subject's skin or the index of oxidation in the subject's skin. A method that includes this.

2. The method according to claim 1, wherein the feature quantity is a phase angle.

3. The method according to claim 2, wherein the correlation is characterized in that the phase angle is the explanatory variable and the index relating to glycation or the index relating to oxidation is the dependent variable.

4. The method according to claim 1, further comprising estimating the metabolic state of the subject's skin from the estimation results of the glycation indicator or the oxidation indicator.

5. The method according to claim 1, wherein the indicator relating to glycation is advanced glycation end products (AGEs).

6. The method according to claim 1, wherein the indicator for oxidation is melanin.

7. An information processing device that estimates glycation or oxidation in the skin, To estimate the index of glycation in the subject's skin or the index of oxidation in the subject's skin by using the correlation between the measurement results by bioelectrical impedance analysis or the characteristic quantities of said measurement results and the index of glycation in the subject's skin or the index of oxidation in the subject's skin. A program that executes the command.

8. An information processing device for estimating glycation or oxidation in the skin, Estimation unit that estimates an index related to glycation in the subject's skin or an index related to oxidation in the subject's skin by using the correlation between the measurement results by bioelectrical impedance method or the characteristic quantities of said measurement results and an index related to glycation in the subject's skin or an index related to oxidation in the subject's skin. Equipped with an information processing device.

9. A screen generation unit that generates a screen for displaying at least one of the estimation results of the glycation index or the oxidation index, and the estimation results of the skin metabolic state of the subject. The information processing apparatus according to claim 8, further comprising:

Images