Method for preserving a composition containing air bubbles and composition

Abstract

The present invention provides a composition that offers excellent preservation properties and can retain nano-order bubbles. [Solution] A method for storing a composition containing bubbles with a diameter of 1 to 1000 nm is provided, which includes a step of filling a container to an internal pressure of 0.3 to 0.9 MPa. The method also involves preparing the composition to be filled by such a method.

Description

Technical Field

[0001] The present invention relates to a method for preserving a composition containing bubbles and to a composition. More specifically, the present invention relates to a method for preserving a composition containing bubbles having a diameter on the order of nanometers and to a composition.

Background Art

[0002] Conventionally, there are known compositions such as cosmetic compositions for use on human skin that contain bubbles having a diameter on the order of nanometers.

[0003] For example, Patent Document 1 discloses a cosmetic composition that is said to be well-adapted to the skin and has an excellent feeling of use without stickiness even after application of the cosmetic. Here, this cosmetic composition contains a nanobubble liquid and other cosmetic components, the nanobubble liquid contains oil and bubbles, and the diameter of the bubbles is 5 nm to 500 nm.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, it is very difficult to preserve such a composition containing bubbles on the order of nanometers while maintaining the number and properties of the bubbles.

[0006] Therefore, an object of the present invention is to provide a preservation method and a composition that can maintain the number of bubbles even after preservation.

Means for Solving the Problems

[0007] That is, the present invention relates to a method for preserving a composition containing bubbles having a diameter of 1 to 1000 nm and to a composition. Of these, preferred embodiments may be the method for preserving the composition and the composition itself, as listed below. [1] A method for preserving a composition containing bubbles with a diameter of 1 to 1000 nm, A process of filling a container with the composition to an internal pressure of 0.3 to 0.9 MPa. Storage methods including those mentioned. [2] The storage method according to [1], wherein the filling step is a step of filling with the composition and a non-flammable compressed gas. [3] The storage method according to [1] or [2], wherein the container is an aluminum can. [4] The storage method according to any one of [1] to [3], wherein the viscosity of the composition is 0 to 10000 Pa·s and the pH is 2 to 10. [5] The preservation method according to any one of [1] to [4], wherein the composition comprises at least one selected from the group consisting of glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, allantoin or a salt thereof, vitamin C group and its derivatives, tranexamic acid, arbutin, placenta, vitamin B group and its derivatives, vitamin E group and its derivatives, vitamin A group and its derivatives, urea, and polysaccharides. [6] A composition containing bubbles with a diameter of 1 to 1000 nm, filled into a container at an internal pressure of 0.3 to 0.9 MPa, and in which the number of bubbles is maintained at least 90% after storage for at least two months from the time of manufacture. [7] The composition according to [6], which is filled in the container together with a non-flammable compressed gas. [8] The composition according to [6] or [7], wherein the container is an aluminum can. [9] The composition according to any one of [6] to [8], wherein the viscosity of the composition is 0 to 10000 Pa·s and the pH is 2 to 10.

[10] A composition according to any one of [6] to [9], comprising at least one selected from the group consisting of glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, allantoin or a salt thereof, vitamin C group and its derivatives, tranexamic acid, arbutin, placenta, vitamin B group and its derivatives, vitamin E group and its derivatives, vitamin A group and its derivatives, urea, and polysaccharides.

[11] The composition according to any one of [6] to

[10] , characterized in that the composition is a topical skin preparation, an oral care product, a cleansing product, or a hair-related product. [Effects of the Invention]

[0008] According to the present invention, it is possible to suppress the reduction in the number of bubbles in a composition containing a large amount of bubbles with a diameter on the order of nanometers. [Brief explanation of the drawing]

[0009] [Figure 1] This is a central cross-sectional view of one embodiment of an aerosol product equipped with a mechanism for generating bubbles on the order of nanometers. [Modes for carrying out the invention]

[0010] The following describes in detail the storage method for a composition containing nanometer-order bubbles and embodiments of the composition according to the present invention.

[0011] [Composition containing air bubbles] A bubble-containing composition in one not-limited embodiment of the present invention contains bubbles with a diameter of 1 to 1000 nm, is filled into a container at an internal pressure of 0.3 to 0.9 MPa, and retains at least 90% of the number of bubbles after storage for at least two months from the time of manufacture. The number of bubbles with a diameter of 1 to 1000 nm is preferably 30 million to 10 billion per mL, and more preferably 50 million to 1 billion per mL.

[0012] The measurement of bubbles with a diameter of 1 to 1000 nm is carried out using a Nano Sight NS300 manufactured by Malvern Panalytical Ltd. Although not limited, in one aspect, it is also preferable that the measured value contains fine bubbles with a number concentration of 50 million / mL or more. (Nanoparticle Analyzer) Measurement number range: 1 million to 1 billion / mL Light source wavelength: 405 nm Camera: sCMOS Temperature control range: -5 to 50 °C Particle size: 10 to 1000 nm (Measurement method) When applying the content liquid from the outlet of the container, the applied substance is diluted with pure water to a predetermined weight, and then the amount of bubbles is measured. The amount of bubbles is multiplied by the dilution ratio to convert it to the amount of foaming in the applied substance.

[0013] Filling the container with an internal pressure of 0.3 to 0.9 MPa is First, for example, a content containing bubbles on the nanometer order can be prepared by an ultra-fine bubble generator or the like. After preparation, the content containing bubbles and an inert compressed gas such as nitrogen gas are filled into an aluminum can or the like at a pressure of 0.3 to 0.9 MPa. Alternatively, an inert compressed gas and the content are filled into an aluminum can or the like at a pressure of 0.3 to 0.9 MPa, the content thus obtained is discharged to generate bubbles on the nanometer order, and the liquid is again filled with the inert compressed gas at a pressure of 0.3 to 0.9 MPa, etc. This can be done by methods such as these.

[0014] The composition may contain water or a polyhydric alcohol.

[0015] The water that may be included in the composition is preferably water conforming to the Japanese Pharmacopoeia standards, such as tap water or well water; purified water obtained by treating ordinary water by distillation, ion exchange treatment using an ion exchange membrane, ultrafiltration treatment using an ultrafiltration membrane, or a combination thereof; and sterilized purified water obtained by sterilizing purified water by heating or the like. The water content in the composition is preferably about 0.1 to 98% by mass, and more preferably 1 to 98% by mass. The amount of water can also be 30 to 98% by mass, 40 to 95% by mass, or 50 to 90% by mass. In certain embodiments, 60 to 85% by mass is particularly preferred.

[0016] The polyhydric alcohols that may be included in the composition are not particularly limited, but may include dihydric or higher polyhydric alcohols such as glycerin, dipropylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, sorbitol, and polyethylene glycol. The content of the polyhydric alcohol in the composition is preferably about 0.1 to 60% by mass, and more preferably 0.5 to 50% by mass. The amount of polyhydric alcohol can also be 0.5 to 25% by mass, 0.5 to 20% by mass, or 0.5 to 15% by mass. In certain embodiments, 1 to 15% by mass is particularly preferred.

[0017] The composition may optionally contain polysaccharides. The included polysaccharides may have the function of moisturizing components. Here, polysaccharides are compounds in which many monosaccharides are linked by glycosidic bonds. As the polysaccharide used in the present invention, at least one selected from the group consisting of heparinoid, hyaluronic acid, and sodium hyaluronate is preferred. These polysaccharides can be used individually or in combination of two or more.

[0018] The polysaccharide content in the composition is preferably 0.0001 to 5% by mass, more preferably 0.01 to 4% by mass, and most preferably 0.1 to 3% by mass. When the polysaccharide moisturizing component content is within this range, when applied to the body, such as a human body, as an application containing a large number of bubbles with a diameter of 1 nm to less than 1000 nm, it can penetrate the skin, enhance moisturizing properties, and make it easier to maintain those moisturizing properties.

[0019] The composition of the present invention may also contain, for example, components that can exert medicinal effects, moisturizing components other than polysaccharides, oils, surfactants, thickeners, and the like.

[0020] Examples of medicinal ingredients include anti-inflammatory components such as glycyrrhizic acid or its salts, glycyrrhetinic acid or its salts, allantoin or its salts, vitamin C group and its derivatives, tranexamic acid, arbutin, as well as placenta, vitamin B group and its derivatives, vitamin E group and its derivatives, vitamin A group and its derivatives, and urea, which have skin-soothing effects. These medicinal ingredients can be used individually or in combination of two or more.

[0021] The proportion of these pharmaceutically active ingredients in the composition is not particularly limited. For example, the content of glycyrrhetinic acid, glycyrrhizic acid, or salts thereof in the composition is preferably 0.001 to 5.0% by mass, and more preferably 0.05 to 3.0% by mass. The content of allantoin or salt thereof in the composition is preferably 0.001 to 5.0% by mass, and more preferably 0.05 to 3.0% by mass. The amount of vitamin C group and its derivatives is preferably 0.1 to 50% by mass, and more preferably 1 to 40% by mass. The amount of vitamin E group is preferably 0.01 to 5% by mass, and more preferably 0.02 to 3% by mass. The amount of vitamin A group is preferably 0.0005 to 5% by mass, and more preferably 0.0007 to 3% by mass. The amount of urea is preferably 0.1 to 30% by mass, and more preferably 1 to 20% by mass. When the proportion of these medicinal ingredients falls within this range, they can penetrate the skin and impart various medicinal effects when applied to the skin of humans or other animals.

[0022] Other components that may be included in the composition include ceramides and plant extracts. These function as moisturizing ingredients and can be used alone or in combination of two or more. These non-polysaccharide moisturizing ingredients, when used in combination with polysaccharide moisturizing ingredients, can enhance the moisturizing effect and give the skin firmness and elasticity.

[0023] The proportion of these components in the composition is not particularly limited. For example, the proportion of ceramides and / or plant extracts in the composition is preferably 0.001 to 5.0% by mass, and more preferably 0.05 to 3.0% by mass.

[0024] When the composition is a moisturizing formulation, preferred oils that can be included are hydrocarbons such as squalane, vegetable oils such as olive oil, silicone oils such as dimethylpolysiloxane, fatty acid alcohols with 14 to 22 carbon atoms such as stearyl alcohol and behenyl alcohol, and ester oils such as triethylhexanoin. These oils can be used alone or in combination of two or more. These oils can be used to create emulsions, for example, oil-in-water emulsions or water-in-oil emulsions, which can suppress the evaporation of moisture from the skin to which the product is applied, thereby enhancing the moisturizing effect and giving the skin firmness and elasticity.

[0025] When the composition is a cleaning formulation, preferred oils that can be included are ester oils such as triethylhexanoin, cetyl ethylhexanoate, and isopropyl palmitate; hydrocarbons such as liquid paraffin and light liquid isoparaffin; and vegetable oils such as olive oil and macadamia nut oil. These oils can be used alone or in combination of two or more. These oils improve cleaning power, make the product easier to rinse off, and provide an excellent user experience.

[0026] In the case of a formulation intended for moisturizing, the oil content of composition 2 is preferably 0.05 to 15% by mass, more preferably 0.5 to 10% by mass, and particularly preferably 0.5 to 7% by mass. When the oil content is within this range, as described above, it is possible to suppress the evaporation of moisture from the skin to which the product is applied, thereby enhancing the moisturizing effect and giving the skin firmness and elasticity.

[0027] In the case of a formulation intended for cleaning, the oil content is preferably 10 to 98% by mass, more preferably 15 to 95% by mass, and particularly preferably 20 to 90% by mass. When the oil content is within this range, as described above, the cleaning power is improved, it is easy to rinse off, and an excellent user experience can be obtained.

[0028] Preferred surfactants that can be included in the composition include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

[0029] In formulations where the composition is intended for moisturizing purposes, preferred nonionic surfactants include polyoxyethylene alkyl ethers such as polyoxyethylene cetyl ether and polyoxyethylene stearyl ether, polyoxyethylene fatty acid esters such as polyoxyethylene glycol monostearate, glycerin fatty acid esters such as glyceryl monostearate, polyhydric alcohol fatty acid esters such as sorbitan fatty acid ester and sucrose fatty acid ester, fatty acid esters of polyoxyethylene-added polyhydric alcohols, and fatty acid diethanolamides. Specifically, preferred surfactants include polyoxyethylene sorbitan tetraoleate, polyoxyethylene (20) sorbitan oleate, lauric acid diethanolamide, and coconut oil fatty acid (8-18 carbon atoms) diethanolamide.As anionic surfactants, preferred carboxylic acid-type anionic surfactants include sodium laurate, sodium stearate, sodium laureth-6 carboxylate (sodium polyoxyethylene (4.5) lauryl ether acetate), sodium lauroyl sarcosinate, sodium octanoate, sodium decanoate, sodium myristic acid, sodium palmitate, and sodium coconut oil fatty acid (C8-C18) sarconsinate. As sulfonic acid-type anionic surfactants, preferred are sodium lauryl sulfoacetate, sodium 1-hexanesulfonate, sodium 1-octanesulfonate, sodium 1-decanesulfonate, sodium 1-dodecanesulfonate, sodium toluenesulfonate, sodium cumenesulfonate, and naphthalenedisulfone. Preferred surfactants include disodium acid, trisodium naphthalene trisulfonate, and sodium alpha-olefin sulfonate. Preferred sulfate ester type anionic surfactants include sodium lauryl sulfate, sodium myristyl sulfate, sodium laureth sulfate (polyoxyethylene (3) lauryl ether sulfate sodium), sodium cetyl sulfate, sodium cocoglyceryl sulfate (hydrogenated coconut oil fatty acid glyceryl sulfate sodium), triethanolamine lauryl sulfate, ammonium lauryl sulfate, and triethanolamine laureth sulfate. Preferred phosphate ester type anionic surfactants include sodium lauryl phosphate, sodium polyoxyethylene cetyl ether phosphate (polyoxyethylene (5) cetyl ether phosphate sodium), lauryl phosphate, and potassium lauryl phosphate. Preferred cationic surfactants include quaternary ammonium salts such as tetramethylammonium chloride, tetrabutylammonium chloride, dodecyldimethylbenzylammonium chloride, alkyltrimethylammonium chloride, octyltrimethylammonium chloride, dodecyltrimethylammonium chloride, benzalkonium chloride, and benzethonium chloride. Preferred alkylamine salts include monomethylamine hydrochloride and dimethylamine hydrochloride.Preferred amphoteric surfactants include amine oxide types such as lauryldimethylamine oxide, alkyl (C8-C18)dimethylamine oxide (N,N-dimethylalkyl(C8-C18)amine oxide), coconut alkyldimethylamine oxide, decyldimethylamine oxide, myristyldimethylamine oxide, dihydroxyethyl laurylamine oxide, and oleyldimethylamine oxide, as well as betaine types such as lauryldimethylaminoacetic acid betaine, lauryl hydroxysulfobetaine, stearyldimethylaminoacetic acid betaine, dodecylaminomethyldimethylsulfopropyl betaine, coconut oil fatty acid (C8-C18) amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and lauric acid amidopropyl betaine. These surfactants can be used individually or in combination of two or more.

[0030] Examples of nonionic surfactants in formulations intended for cleaning include polyoxyethylene sorbitan fatty acid esters such as sorbitan tetraoleate and polyoxyethylene sorbitan coconut oil fatty acid esters, polyoxyethylene polyhydric alcohol fatty acid esters such as PEG-8 distearate, glycerin fatty acid esters such as glyceryl monostearate and sorbitan fatty acid esters, polyoxyethylene alkyl ethers such as polyoxyethylene cetyl ether, sorbitan fatty acid esters such as polyoxyethylene sorbitol fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid esters, alkyl polyglucosides, and polyoxyalkylene-modified silicones such as polyoxyethylene methylpolysiloxane copolymers. Among these, polyoxyethylene sorbitan fatty acid esters and polyoxyethylene polyhydric alcohol fatty acid esters are preferred.As anionic surfactants, preferred carboxylic acid-type anionic surfactants include sodium laurate, sodium stearate, sodium laureth-6 carboxylate (sodium polyoxyethylene (4.5) lauryl ether acetate), sodium lauroyl sarcosinate, sodium octanoate, sodium decanoate, sodium myristic acid, sodium palmitate, and sodium coconut oil fatty acid (C8-C18) sarconsinate. As sulfonic acid-type anionic surfactants, preferred are sodium lauryl sulfoacetate, sodium 1-hexanesulfonate, sodium 1-octanesulfonate, sodium 1-decanesulfonate, sodium 1-dodecanesulfonate, sodium toluenesulfonate, sodium cumenesulfonate, and naphthalenedisulfone. Preferred surfactants include disodium acid, trisodium naphthalene trisulfonate, and sodium alpha-olefin sulfonate. Preferred sulfate ester type anionic surfactants include sodium lauryl sulfate, sodium myristyl sulfate, sodium laureth sulfate (polyoxyethylene (3) lauryl ether sulfate sodium), sodium cetyl sulfate, sodium cocoglyceryl sulfate (hydrogenated coconut oil fatty acid glyceryl sulfate sodium), triethanolamine lauryl sulfate, ammonium lauryl sulfate, and triethanolamine laureth sulfate. Preferred phosphate ester type anionic surfactants include sodium lauryl phosphate, sodium polyoxyethylene cetyl ether phosphate (polyoxyethylene (5) cetyl ether phosphate sodium), lauryl phosphate, and potassium lauryl phosphate. Preferred cationic surfactants include quaternary ammonium salts such as tetramethylammonium chloride, tetrabutylammonium chloride, dodecyldimethylbenzylammonium chloride, alkyltrimethylammonium chloride, octyltrimethylammonium chloride, dodecyltrimethylammonium chloride, benzalkonium chloride, and benzethonium chloride. Preferred alkylamine salts include monomethylamine hydrochloride and dimethylamine hydrochloride.Preferred amphoteric surfactants include amine oxide types such as lauryldimethylamine oxide, alkyl (C8-C18)dimethylamine oxide (N,N-dimethylalkyl(C8-C18)amine oxide), coconut alkyldimethylamine oxide, decyldimethylamine oxide, myristyldimethylamine oxide, dihydroxyethyl laurylamine oxide, and oleyldimethylamine oxide, as well as betaine types such as lauryldimethylaminoacetic acid betaine, lauryl hydroxysulfobetaine, stearyldimethylaminoacetic acid betaine, dodecylaminomethyldimethylsulfopropyl betaine, coconut oil fatty acid (C8-C18) amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and lauric acid amidopropyl betaine. These surfactants can be used individually or in combination of two or more.

[0031] In formulations whose composition is intended for moisturizing, the surfactant content is preferably 0.05 to 40.0% by mass, more preferably 0.1 to 30% by mass, and even more preferably 0.3 to 20% by mass. When the surfactant content is within this range, the oil can be uniformly dispersed when it is mixed with the aforementioned oil to create an oil-in-water emulsion, and even after long-term storage, the water and oil will not separate and will maintain a uniform mixed state.

[0032] In formulations intended for cleaning, the surfactant content is preferably 0.5 to 60% by mass, more preferably 1 to 50% by mass, and even more preferably 2 to 40% by mass. When the surfactant content is within this range, it improves cleaning power by allowing it to blend with dirt, makes it easy to rinse, and provides an excellent user experience.

[0033] Preferred thickeners that can be included in the composition include polysaccharides such as xanthan gum, guar gum, methylcellulose, ethylcellulose, and hydrophobized hydroxypropylmethylcellulose, as well as high molecular weight esters such as carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, dextrin palmitate, and inulin stearate. These thickeners can be used alone or in combination of two or more. These thickeners make it easy to spread the product without it running off the skin when applied to the human body or other surfaces.

[0034] The proportion of the thickening agent in the composition is preferably 0.05 to 7% by mass, and more preferably 0.1 to 5% by mass. When the proportion of the thickening agent is within this range, it can be easily spread without running off the skin.

[0035] Furthermore, by including such a thickening agent, the viscosity of the composition can be set to approximately 0 to 100,000 mPa·s at 25°C, preferably 0.5 to 80,000 mPa·s, and more preferably 3 to 60,000 mPa·s. Having the viscosity of the composition within this range allows the bubbles to remain in the application for a longer period when applied to human skin or other surfaces as an application containing bubbles.

[0036] The composition of the present invention may be a solubilized composition, a gel, or an emulsified composition. A solubilized composition has a transmittance of, for example, 50% or more, preferably 70% or more, of light at a wavelength of 660 nm. If it is an emulsified composition, for example, an oil-in-water emulsion is preferred, but an oil-in-water emulsion may also be used. In one embodiment of the present invention, the ratio of the oil phase to the water phase is not limited, but is preferably about 1:0.5 to 99, more preferably about 1:5 to 80, and even more preferably about 1:10 to 50.

[0037] (pH) The composition of the present invention preferably has a pH of 2 to 10 from the viewpoint of component stability or safety. More preferably, the pH is 3 to 7, and even more preferably, 4 to 6.5. The pH of the composition can be measured at 20°C using a commercially available pH meter (for example, the F-52® model manufactured by Horiba, Ltd.).

[0038] (viscosity) The viscosity of the composition of the present invention is preferably about 0 to 100,000 mPa·s, more preferably about 0.5 to 80,000 mPa·s, and even more preferably about 3 to 60,000 mPa·s, from the viewpoint of component stability and the like. Viscosity is measured at 25°C, using SPINDLE No. M4, at a rotation speed of 12 rpm for 3 minutes. However, if the viscosity is 50,000 mPa·s or higher, the rotation speed is set to 6 rpm. If measurement is not possible under the above conditions, the conditions are changed as appropriate and the measurement is performed. The viscosity of the composition can be measured at 25°C using a commercially available viscometer (for example, TVB-10M model manufactured by Toki Sangyo Co., Ltd.).

[0039] (container) The composition of the present invention contains air bubbles, and therefore is housed in a container capable of retaining these bubbles. The container does not necessarily have a mechanism for generating bubbles, but it may also be housed in a container that generates bubbles.

[0040] The shape and material of the container are not particularly limited, but examples of container shapes include rectangular parallelepipeds, cubes, cylinders, and bags. Examples of container materials include aluminum, polyethylene, polyolefin resins such as polypropylene, polyester resins such as polyethylene terephthalate, and glass. Aluminum cans are particularly preferred as they can withstand the high pressure during and after filling.

[0041] The bubble-containing composition of the present invention, produced in this manner, preferably has a total volume of 5 to 1000 ml, and more preferably 10 to 600 ml, when filled in a container. Furthermore, its mass is preferably 10 to 800 g, and more preferably 50 to 500 g.

[0042] The ratio of the composition to a non-flammable compressed gas such as nitrogen is preferably about 3:7 by volume, and more preferably about 6:4.

[0043] (Application) The foam-containing compositions of the present invention can be used as oral care products, cleansing products, hair-related products, and / or topical skin preparations, preferably as topical skin preparations. Topical skin preparations or hair-related products may include formulations for moisturizing purposes and formulations for cleansing purposes. Oral care products include mouthwash and toothpaste, while cleaning products include car cleaners, etc. Hair-related products include hair growth products, hair tonics, shampoos, conditioners, hairsprays, and hair dyes. Topical skin products include lotions, emulsions, cleansers, facial washes, acne facial washes, acne treatments, body soaps, serums, face masks, body creams, hand creams, dermatitis treatments or preventatives, antipruritics, anti-allergic drugs, hand care products, antibacterial agents, and antiviral agents.

[0044] (Dosage form) The dosage form of the composition is not particularly limited, and a typical example is a liquid dispensing type.

[0045] Methods of using the composition of the present invention include dispensing the composition from a container and applying it to the skin.

[0046] The composition of the present invention can be distributed and applied while containing bubbles. It is preferable that the number and properties of the bubbles are maintained both immediately after filling the container with the composition and, for example, two months or more after filling. Here, maintaining bubbles means that the number of bubbles is maintained while maintaining the size of the bubbles at the time of manufacture or filling. For example, it means that 90% or more, preferably 91% or more, and more preferably 94% or more of the fine bubbles having a diameter of 1 to 1000 nm are maintained at the time of filling. The composition of the present invention is less susceptible to external factors such as temperature and humidity, and can maintain a number of bubbles on the order of nanometers even under high temperature and high humidity conditions, for example, above 35°C or 40°C.

[0047] [Method for producing a composition containing air bubbles] The method for producing the bubble-containing composition of the present invention is not particularly limited, and it can be prepared by mixing the raw materials of the composition and generating nanometer-order bubbles in the mixture. The method for generating nanometer-order bubbles is not particularly limited, and known swirling liquid flow type bubble generators, static mixer type bubble generators, ejector type bubble generators, Venturi type bubble generators, pressurized micropore type bubble generators, pressurized dissolution type bubble generators, etc., can be used. Alternatively, it can be prepared using a bubble-generating container as described in the examples.

[0048] An example of a bubble-generating container is shown in Figure 1. Here, the bubble-generating container consists of a container 1, a composition contained in the container 1, a mounting cup 3 covering the opening of the container 1, a stem 4 inserted approximately in the center of the mounting cup 3 and having a discharge hole that can discharge the composition to the outside of the container 1 and a stem hole 41 that communicates with the discharge hole and also with the inside of the container 1, an elastic spring 5 that biases the stem 4 upward, a tube 6 fitted at the bottom of the mounting cup 3 and leading the composition to the stem 4, and a lid 7 provided on the top of the stem 4 having an application opening 71 that communicates with the discharge hole of the stem 4. The pressure of the composition and non-flammable compressed gas G contained in the container 1 is higher than the pressure outside the container 1. Therefore, when the lid 7 is pressed down, the elastic spring 5 pushes against the biasing force and also presses down the stem 4, causing the stem hole 41 to communicate with the inside of the container 1, and the composition pressed by the non-flammable compressed gas G is discharged to the outside through the tube 6 and stem 4 and the opening 71 of the lid 7, including the composition containing fine bubbles.

[0049] The non-flammable compressed gas G is filled inside the container 1 together with the composition and is a gas at a pressure higher than atmospheric pressure inside the container 1. By filling with non-flammable compressed gas G, a large amount of bubbles can be included when discharged. Furthermore, when the lid 7 is pressed, the non-flammable compressed gas G may be discharged to the outside together with the composition. Therefore, if non-flammable compressed gas G is used together with the composition, it will not ignite or burn due to fire, making it very safe. The non-flammable compressed gas is preferably nitrogen, carbon dioxide, nitrous oxide, helium, argon, or compressed air, and it is more preferable that it contains nitrogen, which is poorly soluble in water. When compressed nitrogen is used as the non-flammable gas G, it is preferable that it contains 99.9% or more nitrogen, and more preferably 99.99% or more.

[0050] Furthermore, the pressure of the non-flammable compressed gas G filled in container 1 together with the composition is preferably 0.1 to 1.0 MPa at 25°C, and more preferably 0.3 to 0.9 MPa. When the pressure of the non-flammable compressed gas G is within this range, the composition is smoothly discharged together with the non-flammable compressed gas G, and a large amount of bubbles with a diameter of approximately 1 nm to less than 1000 nm can be contained during discharge and / or skin application.

[0051] The shape of the nozzle portion 71 is not particularly limited. In one embodiment, it may be a shape integrated with a member that covers the joint portion 72 that is in contact with the nozzle 71. Alternatively, in another embodiment, the nozzle 71 may be a structure that is coupled to the joint portion 72.

[0052] The nozzle section can have shapes such as cylindrical, elliptical, oblong, or polygonal.

[0053] In one embodiment, the length of the nozzle portion is preferably about 5 to 70 mm, more preferably about 10 to 65 mm, and even more preferably about 15 to 60 mm.

[0054] The shape of the nozzle tip opening (discharge part) may be circular, elliptical, triangular, square, or any other polygon. The area of ​​the opening should be 1.5 to 20 mm². 2 A degree of 3-15mm is preferable. 2 A more moderate degree would be preferable.

[0055] In one embodiment, the inner diameter (maximum inner diameter; length indicated by h) of the nozzle tip opening (discharge section) is preferably about 1 to 10 mm, more preferably about 1 to 8 mm, and even more preferably about 1.2 to 5 mm.

[0056] The nozzle length L and the inner diameter of the nozzle tip opening are preferably L / h = 1 to 20, more preferably 1 to 15, and even more preferably 1 to 12.

[0057] Other conditions in the method for producing the composition of the present invention shall be in accordance with those described in [Compositions containing bubbles].

[0058] [Method for preserving compositions containing air bubbles] The present invention also relates to a method for storing a composition containing bubbles with a diameter of 1 to 1000 nm, the method comprising the step of filling a container with the composition to an internal pressure of 0.3 to 0.9 MPa. Herein, although not limited thereto, it is preferable that the composition containing bubbles with a diameter of 1 to 1000 nm contains 100 million bubbles / mL or more.

[0059] The aforementioned filling process may involve filling a container with a composition containing bubbles with a diameter of 1 to 1000 nm together with a non-flammable compressed gas such as nitrogen, thereby achieving an internal pressure of 0.3 to 0.9 MPa, while maintaining airtightness and preventing a decrease in internal pressure.

[0060] Other conditions in the preservation method of the present invention are in accordance with those described in [Compositions containing bubbles]. [Examples]

[0061] The compositions of the present invention will be described in detail below. However, the present invention is not limited to the following examples.

[0062] The composition of Formulation A shown in Table 1 was prepared. The preparation involved mixing each component in a 200 ml Griffin beaker at room temperature of 25°C. [Table 1]

[0063] (Manufacturing example) Formula A and purified water were each filled into 70 mL aluminum cans, and the mounting cup, stem, and lid were attached. Nitrogen was then added through the stem to create an aerosol product with an internal pressure of 0.8 MPa. The container for the aerosol product was as shown in Figure 1, a cylindrical aluminum can with a diameter of 45 mm, and a cylindrical nozzle with a mouth diameter of 3 mm and a length of 35 mm.

[0064] (Examples) The composition obtained from Formulation A and the composition obtained from purified water, both dispensed from the aerosol product obtained in the manufacturing example, were further filled into aluminum cans at a rate of 70 mL each. A mounting cup, stem, and lid were attached, and nitrogen was filled through the stem to an internal pressure of 0.8 MPa to create the aerosol container compositions of Examples 1 and 2.

[0065] (Comparative example) The composition obtained from Formulation A and the composition obtained from purified water, both dispensed from the aerosol product obtained in the manufacturing example, were further filled into aluminum cans at a rate of 70 mL each. A mounting cup, stem, and lid were attached, and nitrogen was filled through the stem to bring the internal pressure to atmospheric pressure (0.1 MPa) to create the aerosol container compositions of Comparative Examples 1 and 2.

[0066] [Test to confirm the number of bubbles] The aerosol-container compositions of the examples and comparative examples were dispensed from the aerosol containers, and the number of microbubbles during filling was measured. Each aerosol-container composition was stored at 25°C in its original container, and nitrogen was removed from the top of each aerosol product at various time intervals. The number of bubbles in Formulation A and purified water was then measured.

[0067] For each example and comparative example, the amount of bubbles with a diameter of 1 to less than 1000 nm in the ejected material when the liquid composition was dispensed was measured. The measurements were performed using a Nano Sight NS300 manufactured by Malvern Panalytical Ltd.

[0068] For each example and comparative example of aerosol product, the amount of bubbles was measured after diluting the product to a predetermined weight with degassed water when the liquid contents were applied from the nozzle. This amount of bubbles was then multiplied by the dilution ratio to obtain the amount of bubbles in the product.

[0069] Table 2 shows the change in the number of bubbles (%) in the compositions of the examples and comparative examples, with the number of bubbles at the time of filling set to 100. Note that all compositions had more than 100 million bubbles at the time of filling.

[0070] [Table 2]

[0071] As shown in Table 2, the composition of the example retained more than 90% of its bubble count even after 2 months of storage, whereas the comparative composition showed a greater reduction in bubbles than the composition of the example. [Explanation of Symbols]

[0072] 1...container 2...composition 3. Mounting Cup 4. Stem 41... Stem hole 5. Elastic spring 6... Tubes 7...Lid part 71...Applicable opening G... Non-flammable compressed gas 72...junction 73.. Cylindrical section 74. Container coating

Claims

1. A method for preserving a composition containing bubbles with a diameter of 1 to 1000 nm, A step of filling a container with the composition so that the internal pressure is 0.3 to 0.9 MPa. Storage methods including those mentioned.

2. The storage method according to claim 1, wherein the filling step is a step of filling with a composition and a non-flammable compressed gas.

3. The storage method according to claim 1, wherein the container is an aluminum can.

4. The storage method according to claim 1, wherein the viscosity of the composition is 0 to 10,000 Pa·s and the pH is 2 to 10.

5. The preservation method according to claim 1, wherein the composition comprises at least one selected from the group consisting of glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, allantoin or a salt thereof, vitamin C group and its derivatives, tranexamic acid, arbutin, placenta, vitamin B group and its derivatives, vitamin E group and its derivatives, vitamin A group and its derivatives, urea, and polysaccharides.

6. A composition containing bubbles with a diameter of 1 to 1000 nm, filled into a container at an internal pressure of 0.3 to 0.9 MPa, wherein the number of bubbles is maintained at 90% or more after storage for at least two months from the time of manufacture.

7. The composition according to claim 6, wherein the container is filled with nitrogen.

8. The composition according to claim 6, wherein the container is an aluminum can.

9. The composition according to claim 6, wherein the viscosity of the composition is 0 to 10,000 Pa·s and the pH is 2 to 10.

10. The composition according to claim 6, comprising at least one selected from the group consisting of glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, allantoin or a salt thereof, vitamin C group and its derivatives, tranexamic acid, arbutin, placenta, vitamin B group and its derivatives, vitamin E group and its derivatives, vitamin A group and its derivatives, urea, and polysaccharides.

11. The composition according to claim 6, characterized in that the composition is a topical skin preparation, an oral care product, a cleansing product, or a hair-related product.

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