Reaction vessel and reaction vessel system

Abstract

The present invention relates to a reaction vessel and a reaction vessel system, wherein the reaction vessel comprises a body portion, a first storage portion disposed within the body portion, movable in an up-down direction, and including a first storage space therein, a second storage portion disposed within the body portion, movable in an up-down direction, including a second storage space therein, and disposed on a first direction side, which is one of the left-right directions with respect to the first storage portion, and a mixing portion including a mixing space that communicates with the first storage space when the first storage portion is positioned at its lowest end, and that communicates with the second storage space when the second storage portion is positioned at its lowest end, and the mixing portion comprises a first inclined portion formed with an upward inclination relative to the first direction, and a second inclined portion formed with an upward inclination relative to the first direction, positioned in the first direction of the first inclined portion, and having a smaller degree of inclination than the first inclined portion.

Description

[Technical Field]

[0001] The present invention claims the benefit of priority based on Korean Patent Application Nos. 10-2023-0057933 filed May 3, 2023 and 10-2024-0036739 filed March 15, 2024, and all contents disclosed in the documents of the relevant Korean patent applications are incorporated herein by reference.

[0002] The present invention relates to a reaction vessel and a reaction vessel system. [Background technology]

[0003] Molecular diagnosis is a method of detecting nucleic acids (DNA and RNA or variants of these) of disease-causing bacteria, viruses, etc. to determine the cause of the disease and whether or not an infection is present.

[0004] Such molecular diagnostic processes include a pre-processing step to obtain pure DNA or RNA from animal cells, plant cells, bacteria, and viruses, a target gene amplification step in DNA or RNA, and a step to analyze the amplified product to detect the cause of disease and whether or not there is an infection.

[0005] In other words, in order to detect the cause of a disease or whether or not an infection is present using a very small amount of gene, it is necessary to amplify the gene. One of these is the polymerase chain reaction (PCR), which is a technology that involves repeatedly heating and cooling genetic material to replicate a specific base sequence in a chain reaction, thereby exponentially amplifying the genetic material containing that specific base sequence.

[0006] Isothermal amplification, which can amplify specific base sequence sites of nucleic acids by replicating them in a chain-like manner at a predetermined temperature, can also be applied.

[0007] Recently, devices have been developed that allow individuals to individually carry out gene amplification and detection processes using kit or cartridge-type containers to determine whether they are infected or not.

[0008] Conventional testing devices have a problem in that all components used for testing are separate, the usage process is complicated, and there are many steps involved, which increases the probability of variations in result values ​​depending on the user.

[0009] Furthermore, the specimen is exposed to the external environment at each step, which may result in contamination of the specimen. Summary of the Invention [Problem to be solved by the invention]

[0010] The object of the present invention is to provide a reaction vessel which is simple to use and which reduces the risk of contamination. [Means for solving the problem]

[0011] In one example, the reaction vessel may include a body portion, a first storage portion disposed within the body portion, movable in an up-down direction, and including a first storage space therein, a second storage portion disposed within the body portion, movable in an up-down direction, and including a second storage space therein, and disposed on a first direction side, which is one of the left-right directions, based on the first storage portion, a mixing portion including a mixing space that communicates with the first storage space when the first storage portion is positioned at its lowest end, and that communicates with the second storage space when the second storage portion is positioned at its lowest end, and a reaction detection portion whose lower end comes into contact with the mixed reactant positioned within the mixing space and then reacts with the mixed reactant to produce a detection reaction.

[0012] In another example, the first storage section includes a first storage section body that defines the first storage space that opens upward and downward, and a first lower cover that is connected to the lower part of the first storage section body and covers the lower part of the first storage space, and the mixing section includes a first breaking member that communicates with the mixing space and defines a first input space that extends above the mixing space, and the first breaking member can be configured to penetrate the first lower cover and communicate the first storage space with the first input space when the first storage section moves downward.

[0013] In yet another example, the first storage section may further include a first storage section body defining the first storage space that opens at the top and bottom, and a first upper cover coupled to the top of the first storage section body and opening and closing the top of the first storage space.

[0014] In yet another example, an upper portion of the first storage body may be formed to be inclined upward with respect to the first direction, and the first upper cover may have a shape corresponding to the upper portion of the first storage body.

[0015] In yet another example, the first upper cover is slidably connected to the upper part of the first storage body in the left-right direction, and can open the upper part of the first storage space when moving in a second direction opposite to the first direction, and can close the upper part of the first storage space when moving in the first direction.

[0016] In yet another example, the second storage section includes a second storage section body that defines the second storage space that opens upward and downward, and a second lower cover that is connected to the lower part of the second storage section body and covers the lower part of the second storage space, and the mixing section includes a second breaking member that communicates with the mixing space and defines a second input space that extends above the mixing space, and the second breaking member can be configured to penetrate the second lower cover and communicate the second storage space with the second input space when the second storage section moves downward.

[0017] In yet another example, the second storage section may further include an opening formed at the top of the second storage section body and an opening cover arranged to close the opening, and the body section may include an opening breaking member that breaks the opening cover and opens the opening when the second storage section moves downward.

[0018] In yet another example, the opening is formed in a side wall of the second storage body, the opening breaking member contacts the underside of the area of ​​the second storage body that defines the opening to support the second storage body upward, the surface of the opening breaking member that contacts the second storage body is formed as an inclined surface, and when the second storage body moves downward, the opening breaking member moves so that the end facing the second storage body contacts the second storage body, and after elastically supporting the second storage body, it can contact the opening cover.

[0019] In yet another example, the body portion further includes a communicating opening formed in a wall corresponding to the position of the opening when the second storage portion body is moved downward, and the opening-breaking member can be positioned within the communicating opening.

[0020] In yet another example, the first storage section may include a first storage section body that defines the first storage space that opens upward and downward, and a locking opening formed in the first storage section body that opens upward, and the second storage section may include a second storage section body that defines the second storage space that opens upward and downward, and a locking member that protrudes from the second storage section body and passes through the locking opening.

[0021] In yet another example, the reaction detection unit is connected to the second storage unit by the locking member, is movable in the vertical direction, and can be positioned on the second direction side of the first storage unit, which is opposite to the first direction.

[0022] In yet another example, the body portion includes a first guide opening formed on a wall of the body portion in the vertical direction and on a third direction side perpendicular to the first direction, and opening upward, and a second guide opening located on the first direction side of the first guide opening and opening upward, the first storage portion includes a first storage portion body defining the first storage space opening vertically, and a first guide protrusion protruding from the first storage portion body in the third direction and inserted into the first guide opening, and the second storage portion includes a second storage portion body defining the second storage space opening vertically, and a second guide protrusion protruding from the second storage portion body in the third direction and inserted into the second guide opening.

[0023] In yet another example, the first guide opening may be formed to be narrower than the diameter of the first guide protrusion and include a first obstruction region that obstructs downward movement of the first guide protrusion, and the second guide opening may be formed to be narrower than the diameter of the second guide protrusion and include a second obstruction region that obstructs downward movement of the second guide protrusion.

[0024] In yet another example, an activation prevention opening that opens upward is formed in the side wall of the body part, and the first storage part includes a first storage part body that defines the first storage space that opens upward and downward, and an activation prevention member that protrudes from the first storage part body and is placed on the activation prevention opening, and the activation prevention member includes a first part that protrudes from the first storage part body toward the side wall of the body part, and a second part that protrudes downward from the first part and is placed on the activation prevention opening.

[0025] In yet another example, a surface of the mixer that defines a lower portion of the mixing space may be formed to be inclined upward with respect to the first direction.

[0026] In yet another example, a freeze-dried buffer solution is placed in the mixing space, a reaction liquid configured to react with a sample collected from a user is placed in the first storage space, and a developing liquid configured to develop the reaction liquid mixed with the buffer solution into the reaction detection unit is placed in the second storage space, and the buffer solution may contain an enzyme and a primer.

[0027] In one example, a reaction vessel system includes a reaction vessel and a heating device configured to have the reaction vessel inserted into an internal insertion space and to heat the underside of the reaction vessel, and the reaction vessel includes a body portion, a first storage portion disposed within the body portion, movable in an up and down direction, and including a first storage space therein, a second storage portion disposed within the body portion, movable in an up and down direction, and including a second storage space therein, and a mixing portion including a mixing space that communicates with the first storage space when the first storage portion is positioned at the lowest end, and that communicates with the second storage space when the second storage portion is positioned at the lowest end.

[0028] In another example, the heating device may include a heating section that contacts the underside of the mixing section to heat the mixing space, and a first switch that is pressurized by the underside of the reaction vessel when the reaction vessel is inserted into the insertion space, thereby activating the heating section.

[0029] In yet another example, an activation prevention opening that opens upward is formed on the side wall of the body part, the first storage part includes a first storage part body that defines the first storage space that opens upward and downward, and an activation prevention member that protrudes from the first storage part body and is placed on the activation prevention opening, the activation prevention member includes a first part that protrudes from the first storage part body toward the side wall of the body part, and a second part that protrudes downward from the first part and is placed on the activation prevention opening, and the heating device includes an activation initiation protrusion that protrudes from the surface that defines the insertion space toward the second part and pressurizes the second part to remove it from the activation prevention opening when the reaction vessel moves downward.

[0030] In yet another example, the body portion includes a first actuating opening that opens upward and a second actuating opening that is located on the first direction side of the first actuating opening and also opens upward, the first storage portion includes a first storage portion body that defines the first storage space that opens upward and downward, and a first actuating protrusion that is inserted into the first actuating opening and protrudes from the first storage portion body through the first actuating opening, the second storage portion includes a second storage portion body that defines the second storage space that opens upward and downward, and a second actuating protrusion that is inserted into the second actuating opening and protrudes from the second storage portion body through the second actuating opening, and the heating device may include a signal generating unit that generates a predetermined signal to a user, a second switch that is located at a position corresponding to the first actuating protrusion and that activates the signal generating unit to generate the signal after a first reference time when pressurized by the first actuating protrusion, and a third switch that is located at a position corresponding to the second actuating protrusion and that activates the signal generating unit to generate the signal after a second reference time when pressurized by the second actuating protrusion.

[0031] In one example, the reaction vessel includes a body portion, a first storage portion disposed within the body portion, movable in the vertical direction, and including a first storage space therein, a second storage portion disposed within the body portion, movable in the vertical direction, including a second storage space therein, and disposed on a first direction side, which is one of the left and right directions, based on the first storage portion, and a mixing portion including a mixing space that communicates with the first storage space when the first storage portion is positioned at its lowest end and communicates with the second storage space when the second storage portion is positioned at its lowest end, and the mixing portion includes a first inclined portion formed with an upward inclination relative to the first direction, and a second inclined portion formed with an upward inclination relative to the first direction, positioned in the first direction of the first inclined portion, and having a smaller degree of inclination than the first inclined portion.

[0032] In another example, when viewed in the vertical direction, the first inclined portion may include an area that overlaps with the first storage section, and the second inclined portion may include an area that overlaps with the second storage section.

[0033] In yet another example, the first storage section includes a first storage section body that defines the first storage space that opens upward and downward, and a first lower cover that is connected to the lower part of the first storage section body and covers the lower part of the first storage space, and the mixing section includes a first breaking member that communicates with the mixing space and defines a first input space that extends above the mixing space, and the first breaking member can be configured to penetrate the first lower cover and communicate the first storage space with the first input space when the first storage section moves downward.

[0034] In yet another example, the first storage section may further include a first obstruction portion that protrudes from the inner surface of the first storage section body toward the first storage space and is configured to obstruct the entry of collection tools inserted into the first storage space.

[0035] In yet another example, the first storage space may include an upper space located above the first obstructing portion and a lower space located below the first obstructing portion, and the vertical length of the upper space may be shorter than the vertical length of the lower space.

[0036] In yet another example, the second storage section includes a second storage section body that defines the second storage space that opens upward and downward, and a second lower cover that is connected to the lower part of the second storage section body and covers the lower part of the second storage space, and the mixing section includes a second breaking member that communicates with the mixing space and defines a second input space that extends above the mixing space, and the second breaking member can be configured to penetrate the second lower cover and communicate the second storage space with the second input space when the second storage section moves downward.

[0037] In yet another example, the second storage section may further include an opening formed in the upper part of the second storage section body and an opening cover arranged to close the opening, and the body section may include an opening breaking member arranged to break the opening cover when the second storage section moves downward.

[0038] In yet another example, the opening is formed in the side wall of the second storage body and has a shape that is inclined upward with respect to the first direction, and when viewed along the vertical direction, the end of the opening-breaking member and the opening cover can overlap each other.

[0039] In yet another example, the end of the aperture-breaking member can be seen upward.

[0040] In yet another example, the first storage section may further include a first locking opening formed in the first storage section body, opening upward, and opening along the first direction, and the second storage section may further include a locking member protruding from the second storage section body and penetrating the first locking opening along the opposite direction to the first direction.

[0041] In yet another example, the locking member is formed with a second locking opening that opens downward and along a direction perpendicular to the first direction, and when the first storage section and the second storage section are positioned at the uppermost end or when the first storage section and the second storage section are positioned at the lowermost end, the area of ​​the first storage section body that defines the first locking opening and the area of ​​the locking member that defines the second locking opening can engage with each other.

[0042] In yet another example, the container further includes a reaction detection unit whose lower end comes into contact with the mixed reactant located in the mixing space and then reacts with the mixed reactant to exhibit a detection reaction, and the reaction detection unit is formed in a fitting region, which is a region of the locking member located on a second direction side that is opposite to the first direction of the first storage unit, and whose upper end can be fitted into a fitting opening that opens downward.

[0043] As yet another example, the fitting region may further include a placement opening that opens toward the second direction and in which the reaction detection unit is placed.

[0044] In yet another example, the body portion may further include a passage portion that opens upward and downward and is provided so as to surround a portion of the reaction detection portion.

[0045] In yet another example, the body portion includes a first operating opening that opens upward and a second operating opening that opens upward and is located in the first direction of the first operating opening, the first storage portion includes a first storage portion body that defines the first storage space that opens upward and downward, a first operating protrusion that is inserted into the first operating opening and protrudes from the first storage portion body through the first operating opening, and a first magnet that is coupled to an end of the first operating protrusion, and the second storage portion includes a second storage portion body that defines the second storage space that opens upward and downward, a second operating protrusion that is inserted into the second operating opening and protrudes from the second storage portion body through the second operating opening, and a second magnet that is coupled to an end of the second operating protrusion.

[0046] In yet another example, the reaction vessel may further include an actuation protrusion protruding downward from the lower surface of the mixer, and an actuation magnet coupled to an end of the actuation protrusion.

[0047] In yet another example, the mixing section may further include a mixing opening that communicates with the mixing space, is located on the opposite side of the first inclined portion from the first direction, and opens upward.

[0048] In one example, a reaction vessel system includes a reaction vessel and a heating device configured to insert the reaction vessel into an internal insertion space and heat the underside of the reaction vessel, wherein the reaction vessel includes a body portion, a first storage section disposed within the body portion, movable in an up-and-down direction, and including a first storage space therein, a second storage section disposed within the body portion, movable in an up-and-down direction, including a second storage space therein, and disposed on a first direction side, which is one of the left and right directions based on the first storage section, and a mixing section including a mixing space that communicates with the first storage space when the first storage section is positioned at its lowest end and communicates with the second storage space when the second storage section is positioned at its lowest end, and the mixing section includes a first inclined portion formed with an upward inclination relative to the first direction, and a second inclined portion formed with an upward inclination relative to the first direction, positioned in the first direction of the first inclined portion, and having a smaller inclination than the first inclined portion.

[0049] In another example, the reaction vessel system further includes an actuating protrusion protruding downward from the underside of the mixing section and an actuating magnet coupled to an end of the actuating protrusion, the mixing section further includes a mixing opening communicating with the mixing space, located on the opposite side of the first direction of the first inclined portion, and opening upward, and the heating device may include a heating section configured to contact a region of the mixing section defining the mixing opening and heat the mixing opening, and a first sensing member configured to sense the actuating magnet when the reaction vessel is inserted into the insertion space.

[0050] In yet another example, the body portion includes a first actuation opening that opens upward and a second actuation opening that opens upward and is located in the first direction of the first actuation opening, the first storage portion includes a first storage portion body that defines the first storage space that opens upward and downward, a first actuation protrusion that is inserted into the first actuation opening and protrudes from the first storage portion body through the first actuation opening, and a first magnet that is coupled to an end of the first actuation protrusion, and the second storage portion includes a second storage portion body that defines the second storage space that opens upward and downward, and a second actuation protrusion that is inserted into the second actuation opening and protrudes from the second storage portion body through the first actuation opening. The heating device may include a second actuating protrusion protruding through the second actuating opening and a second magnet coupled to an end of the second actuating protrusion, and may further include a signal generating unit configured to generate a predetermined signal to a user, a second sensing member disposed at a position corresponding to the first actuating protrusion and configured to activate the signal generating unit to generate the signal after a first reference time when detecting the first magnet, and a third sensing member disposed at a position corresponding to the second actuating protrusion and configured to activate the signal generating unit to generate the signal after a second reference time when detecting the second magnet. [Effects of the Invention]

[0051] According to the present invention, the components required for the detection of an analyte are located in one reaction vessel, simplifying use and reducing the risk of contamination. [Brief explanation of the drawings]

[0052] [Figure 1] FIG. 1 is a perspective view showing a reaction vessel according to a first embodiment of the present invention. [Figure 2] A view of Figure 1 from another direction. [Figure 3] FIG. 1 is an exploded perspective view of a reaction vessel according to a first embodiment of the present invention. [Figure 4] FIG. 3 is a view showing the reaction vessel according to the first embodiment of the present invention as viewed from the third direction side. [Figure 5] FIG. 3 is a view showing the reaction vessel according to the first embodiment of the present invention as viewed from the fourth direction side. [Figure 6] 1 is a cross-sectional view of a reaction vessel according to a first embodiment of the present invention. [Figure 7] FIG. [Figure 8] FIG. 10 is a diagram showing the first upper cover and the anti-detachment member. [Figure 9] 10 is a diagram showing the state in which the opening cover is broken by the opening breaking member. FIG. [Figure 10] FIG. 2 is a cutaway perspective view of the lower part of the reaction vessel according to the first embodiment of the present invention. [Figure 11] 11 is a diagram showing the state in which the first storage section in FIG. 10 has moved downward. [Figure 12] 12 is a diagram showing the state in which the second storage section in FIG. 11 has moved downward. FIG. [Figure 13] FIG. 1 is a diagram conceptually illustrating the operation of a reaction vessel. [Figure 14] FIG. [Figure 15] 1 is a diagram showing a heating device according to a first embodiment of the present invention. [Figure 16] 1 is a diagram showing a heating device according to a first embodiment of the present invention as viewed from above. [Figure 17] FIG. 10 is a perspective view showing a reaction vessel according to a second embodiment of the present invention. [Figure 18] FIG. 18 is a view showing FIG. 17 as viewed from another direction. [Figure 19] FIG. 10 is an exploded perspective view of a reaction vessel according to a second embodiment of the present invention. [Figure 20] FIG. 1 is a perspective view showing a swab. [Figure 21] FIG. 10 is a cross-sectional view of a reaction vessel according to a second embodiment of the present invention, with a swab placed in the first internal space. [Figure 22] FIG. 10 is a diagram showing a second storage section of a reaction vessel according to a second embodiment of the present invention. [Figure 23] 23 is a view showing the second storage section of FIG. 22 as viewed from another direction. FIG. [Figure 24] FIG. 10 is a diagram showing both the first locking opening and the second locking opening. [Figure 25] FIG. 10 is a diagram showing the first storage section and the second storage section before they are moved downward. [Figure 26] 26 is a diagram showing the state in which the first storage section in FIG. 25 has moved downward. [Figure 27] 27 is a diagram showing the state in which the second storage section in FIG. 26 has moved downward. [Figure 28] FIG. 4 is a diagram showing a heating device according to a second embodiment of the present invention. [Figure 29] FIG. 10 is a diagram showing a heating device according to a second embodiment of the present invention as viewed from above. [Figure 30] FIG. 10 is a diagram showing a state in which a reaction vessel is placed inside a heating device according to a second embodiment of the present invention. [Figure 31] FIG. 4 is a diagram showing the operation sequence of a reaction vessel system according to a second embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0053] Some embodiments of the present invention will now be described in detail with reference to exemplary drawings. In assigning reference numerals to the components in each drawing, the same reference numerals are used for the same components even if they appear in different drawings. Furthermore, when describing embodiments of the present invention, if it is determined that a detailed description of related known configurations or functions would hinder understanding of the embodiments of the present invention, the detailed description will be omitted.

[0054] The reactor and reactor system are described in more detail below. The reaction vessel system can include a reaction vessel and a heating device. The reaction vessel may be a vessel for carrying out a PCR reaction and reaction detection. The heating device can be provided so that the reaction vessel is inserted into the internal insertion space, and can be provided so as to heat the underside of the reaction vessel. The insertion space can be open upward.

[0055] Embodiment 1 In the following, the reaction vessel according to the first embodiment will be described in detail first. FIG. 1 is a perspective view illustrating a reaction vessel according to a first embodiment of the present invention. FIG. 2 is a view showing the state of FIG. 1 as seen from another direction. FIG. 3 is an exploded perspective view of the reaction vessel according to the first embodiment of the present invention. FIG. 4 is a diagram illustrating the reaction vessel according to the first embodiment of the present invention as viewed from the third direction D3. FIG. 5 is a view illustrating the reaction vessel according to the first embodiment of the present invention as viewed from the fourth direction D4. FIG. 6 is a cross-sectional view of a reaction vessel according to the first embodiment of the present invention.

[0056] Hereinafter, the first direction D1 is defined as the left-right direction in which a first storage unit 200 (described later) looks at a second storage unit 300 (described later), and the opposite direction is defined as a second direction D2. The second storage section 300 may be a component in which the developing liquid is stored. Also, a direction perpendicular to the up-down direction and the first direction D1 is defined as a third direction D3, and the opposite direction is defined as a fourth direction D4.

[0057] reaction vessel The reaction vessel according to the first embodiment of the present invention may include a body part 100 , a first storage part 200 , a second storage part 300 , a mixing part 400 and a reaction detection part 500 . The body part 100 may include a guide member 110 that guides the first storage part 200 and the second storage part 300 in vertical movement. The guide member 110 may include a region that extends vertically and in which the first storage unit 200 and the second storage unit 300 are disposed.

[0058] In addition, the body part 100 may include an exposure area 190 for exposing the reaction detection part 500 to the outside. For example, the exposed area 190 may be formed of a transparent material and may be formed as an opening.

[0059] The first storage section 200 is disposed within the body section 100 and can move up and down. The first storage section 200 may include a first storage space 211 therein. The first storage unit 200 may be a component that stores a reaction liquid that is set to react with a sample collected from a user. In addition, the first storage unit 200 can receive collection tools with samples collected by the user. The collection tool may be, but is not limited to, a cotton swab.

[0060] The second storage part 300 is disposed within the body part 100, is movable in the vertical direction, and can include a second storage space 311 therein. The second storage unit 300 may be arranged on the first direction D1 side, which is one of the left and right directions, based on the first storage unit 200.

[0061] The mixing section 400 may include a mixing space 401 . The mixing section 400 can be disposed below the first storage section 200 and the second storage section 300 . The mixing space 401 can be in communication with the first storage space 211 when the first storage section 200 is positioned at the lowest end, and can be in communication with the second storage space 311 when the second storage section 300 is positioned at the lowest end. A buffer solution can be placed in the mixing space 401 . The buffer solution can be stored frozen. The buffer solution can include an enzyme and a primer.

[0062] A portion of a surface of the mixer 400 that defines the lower portion of the mixing space 401 may be inclined upward with respect to the first direction D1. This may be a structure for moving a reaction solution, a developing solution, etc. by using an inclination.

[0063] The reaction detection unit 500 may be configured such that a lower end thereof contacts the mixed reactant positioned in the mixing space 401 and then reacts with the mixed reactant to exhibit a detection reaction. The reaction detection unit 500 may be an LFA (Lateral Flow Assay). For example, the reaction detection unit 500 may be connected to the second storage unit 300 and may be linked to the movement of the second storage unit 300 .

[0064] In summary, a freeze-dried buffer solution is placed in the mixing space 401, a reaction liquid that is designed to react with a sample collected from a user is placed in the first storage space 211, and a developing liquid that is designed to develop the reaction liquid mixed with the buffer solution into the reaction detection unit 500 can be placed in the second storage space 311.

[0065] According to the present invention, the first storage section 200, the second storage section 300 and the mixing section 400 required for sample detection are arranged in one body, which simplifies use and reduces the risk of contamination. The specific structure of the device will be described in detail below.

[0066] The first storage section 200 may include a first storage section body 210 and a first lower cover 220 . The first storage body 210 may define a first storage space 211 . The first storage space 211 can be open at the top and bottom. The top of the first storage space 211 may be covered by a first storage space top cover 213 . The first storage space upper cover 213 may be made of a breakable material. For example, the first storage space upper cover 213 may be a silver foil seal.

[0067] The first lower cover 220 is coupled to the lower part of the first storage body 210 and can cover the lower part of the first storage space 211 . The first lower cover 220 may be made of a breakable material. As an example, the first lower cover 220 may be a silver foil seal.

[0068] The mixing section 400 can include a first breaking member 410 . The first breaking member 410 can define a first input space 411 . The first input space 411 may communicate with the mixing space 401 and extend above the mixing space 401 . The first input space 411 may be a space for connecting the first internal space and the mixing space 401 to each other. When the first storage unit 200 moves downward, the first breaking member 410 penetrates the first lower cover 220 to connect the first storage space 211 and the first input space 411 to each other.

[0069] A first lower sealing member 212 may be disposed at the bottom of the first storage space 211 . The first lower sealing member 212 may be an O-ring. The first breaking member 410 can be inserted into the first lower sealing member 212 . By inserting the first breaking member 410 into the first lower sealing member 212, when the first lower cover 220 is broken, the contents of the first storage space 211 can be prevented from leaking into spaces other than the first input space 411.

[0070] FIG. 7 is a cross-sectional view of the first upper cover 230. As shown in FIG. FIG. 8 is a diagram illustrating the first upper cover 230 and the separation prevention member 232. The first storage unit 200 may further include a first upper cover 230 . The first upper cover 230 is coupled to the upper part of the first storage body 210 and can open and close the upper part of the first storage space 211 .

[0071] For example, the first upper cover 230 may be coupled to the upper portion of the first storage body 210 so as to be slidable in the left-right direction. The first upper cover 230 can open the upper part of the first storage space 211 when moving in the second direction D2, and can close the upper part of the first storage space 211 when moving in the first direction D1.

[0072] The first upper cover 230 may include a first upper sealing member 231 for maintaining airtightness. As an example, the first upper sealing member 231 may be an O-ring. In addition, the first upper cover 230 may include a downwardly protruding separation prevention member 232 to prevent separation during sliding movement. The separation prevention member 232 may be locked to the first storage body 210 when the first upper cover 230 moves in the second direction D2.

[0073] The upper portion of the first storage body 210 may be formed to be inclined upward with respect to the first direction D1, and the first upper cover 230 may have a shape corresponding to the upper portion of the first storage body 210. Since the upper part of the first storing body 210 has an inclined shape, the upper part of the first storing body 210 and the first upper cover can be in good contact with each other simply by sliding left and right. Therefore, the upper part of the first storage space 211 can be effectively sealed.

[0074] The second storage section 300 may include a second storage section body 310 and a second lower cover 320 . The second storage body 310 may define a second storage space 311 . The second storage space 311 can be open at the top and bottom.

[0075] The second lower cover 320 is coupled to the lower part of the second storage body 310 and can cover the lower part of the second storage space 311 . The second lower cover 320 may be made of a breakable material. As an example, the second lower cover 320 may be a silver foil seal.

[0076] The mixing section 400 can include a second breaking member 420 . The second breaking member 420 can define a second input space 421 . The second input space 421 may communicate with the mixing space 401 and extend above the mixing space 401 . The second input space 421 may be a space for connecting the second internal space and the mixing space 401 to each other.

[0077] When the second storage unit 300 moves downward, the second breaking member 420 penetrates the second lower cover 320 to connect the first storage space 211 and the second input space 421 to each other.

[0078] A second lower sealing member 312 may be disposed at the bottom of the second storage space 311 . The second lower sealing member 312 may be an O-ring. The second breaking member 420 can be inserted into the second lower sealing member 312 . By inserting the second breaking member 420 into the second lower sealing member 312, when the second lower cover 320 is broken, the contents of the first storage space 211 can be prevented from leaking into spaces other than the second input space 421.

[0079] The second storage section 300 may include a second top cover 330 . The second upper cover 330 may be located above the second storage body 310 . The second upper cover 330 may be integrally formed with the second storage body 310 .

[0080] The second storage section 300 may further include an opening 340 and an opening cover 350 . The opening may be formed in the top of the second storage body 310 . The opening 340 may be formed in the sidewall of the second storage body 310 . For example, the opening 340 may be formed in a wall of the second storage body 310 on the first direction D1 side.

[0081] An opening cover 350 can be provided to close the opening 340 . The opening cover 350 may be made of a breakable material. As an example, the opening cover 350 may be a silver foil sealing.

[0082] FIG. 9 is a diagram illustrating the state in which the opening cover 350 is broken by the opening breaking member 120. As shown in FIG. The body portion 100 may include an aperture breaking member 120 . When the second storage section 300 moves downward, the opening breaking member 120 can break the opening cover 350 and open the opening 340 . For example, the opening breaking member 120 can break the opening cover 350 by a restoring force due to elasticity.

[0083] The opening breaking member 120 can contact the lower surface of the second storage body 310 in the area that defines the opening 340, and support the second storage body 310 upward. In addition, the surface of the opening breaking member 120 that contacts the second storage body 310 may be formed as an inclined surface. The inclined surface may be inclined upward with respect to the first direction D1.

[0084] The opening breaking member 120 can move so that the end facing the second storage body 310 comes into contact with the second storage body 310 when the second storage body 310 moves downward. This can be understood as the second storage body 310 pressing downward on the inclined surface, and pressing the opening breaking member 120 in the first direction D1. The opening breaking member 120 can contact the opening cover 350 after its end contacts the second storage body 310 and elastically supports the second storage body 310 . The opening breaking member 120 applies a restoring force to the opening cover 350, so that the opening cover 350 can be broken.

[0085] The body portion 100 may include a communication opening 130 . The communication opening 130 may be formed in the wall corresponding to the position of the opening when the second storage section 300 moves downward. The opening breaking member 120 can be disposed within the communication opening 130 .

[0086] Based on the above, since the opening 340 is opened when the second storage section 300 moves downward, the second storage section 300 forms the second storage space 311 as an open space when it moves downward, whereas the first storage section 200 can form the first storage space 211 as a closed space when it moves downward. However, an ordinary engineer may, as needed, form both the first storage space 211 and the second storage space 311 as open spaces or both as closed spaces, or form the first storage space 211 as an open space and the second storage space 311 as a closed space.

[0087] The first storage space 211 is a closed space, and in the case of the first storage section 200, an amount of reaction liquid corresponding to the volume of the first breaking member 410 placed in the first storage space 211 can be moved to the mixing space 401.

[0088] The second storage space 311 is an open space, and in the case of the second storage section 300, the developing liquid can be moved into the mixing space 401 until the vertical length of the second breaking member 420 located in the second storage space 311 matches the height of the developing liquid inside.

[0089] FIG. 10 is a cutaway perspective view of the lower part of the reaction vessel according to the first embodiment of the present invention. FIG. 11 is a view illustrating a state in which the first storage section 200 in FIG. 10 has moved downward. FIG. 12 is a view illustrating the state in which the second storage section 300 in FIG. 11 has moved downward. FIG. 13 is a diagram conceptually illustrating the operation of the reaction vessel.

[0090] The operation of the reaction vessel according to the first embodiment of the present invention will be conceptually described in detail below with reference to the above content and drawings.

[0091] First, after the user collects a sample using a collection tool, the user moves the first upper cover 230 in the second direction D2 and inserts the collection tool into the first storage space 211. During this process, the first storage space upper cover 213 may break. The sample is allowed to react with the reaction solution.

[0092] Next, the user moves the first storage section 200 downward. During this process, the first lower cover 220 is broken, and the reaction solution and the specimen in the first storage space 211 move to the mixing space 401. During this process, the buffer solution, reaction solution, and specimen present in the mixing space 401 can be mixed.

[0093] Next, the user moves the second storage section 300 downward. During this process, the second lower cover 320 and the opening cover 350 are broken, and the developer in the second storage space 311 moves to the mixing space 401, and the developer further flows into the mixing space 401 to form a mixed reactant. During this process, the reaction detection unit 500 moves downward together with the second storage unit 300, and the reaction detection unit 500 comes into contact with the mixed reactants located in the mixing space 401, thereby detecting the reaction.

[0094] As an example, the above-mentioned operation may be performed after the reaction vessel is inserted into the insertion space 11 of the heating device 10.

[0095] For this operation to occur, the first storage unit 200 must be moved before the second storage unit 300 is moved. The structure for moving the first storage unit 200 before the second storage unit 300 will be described in detail below.

[0096] FIG. 14 is a diagram illustrating the locking opening 240 and the locking member 360. The first storage section 200 may include a locking opening 240 . The locking opening 240 is formed in the first storage body 210 and can open upward. For example, the locking opening 240 may be formed in the upper portion of the first storage body 210 .

[0097] The second storage section 300 may include a locking member 360 . The locking member 360 can protrude from the second storage body 310 and pass through the locking opening 240 . For example, the reaction detection unit 500 is connected to the second storage unit 300 by a locking member 360 and can move up and down. Here, the reaction detection unit 500 may be disposed on the second direction D2 side of the first storage unit 200. However, this is merely an example, and the second storage unit 300 and the reaction detection unit 500 may be connected via a different member instead of the locking member 360.

[0098] Since the locking member 360 passes through the locking opening 240 that opens upward, even if the user accidentally moves the second storage section 300 downward first, the first storage section 200 can also move downward together. If the downward movement of the first storage unit 200 is obstructed, the downward movement of the second storage unit 300 is also obstructed. However, the first storage unit 200 can move downward independently of the second storage unit 300 .

[0099] The following describes in detail the structure that prevents the first storage unit 200 and the second storage unit 300 from suddenly descending when they are moved up and down.

[0100] The body portion 100 may include a first guide opening 140 and a second guide opening 150 . The first guide opening 140 is formed in a wall on the third direction D3 side of the body portion 100 and can open upward. The second guide opening 150 is located on the first direction D1 side of the first guide opening 140 and can open upward.

[0101] The first storage unit 200 may include a first guide protrusion 250 . The first guide protrusion 250 protrudes from the first storage body 210 in the third direction D3 and can be inserted into the first guide opening 140. The second storage unit 300 may include a second guide protrusion 370 . The second guide protrusion 370 protrudes from the second storage body 310 in the third direction D3 and can be inserted into the second guide opening 150.

[0102] The first guide opening 140 may include a first obstruction area. The first obstruction area may be formed to have a width narrower than the diameter of the first guide protrusion 250, and may be an area that obstructs the downward movement of the first guide protrusion 250. The second guide opening 150 can include a second obstruction area. The second obstruction area may be formed to have a width narrower than the diameter of the second guide protrusion 370, and may be an area that obstructs the downward movement of the second guide protrusion 370.

[0103] When the first storage unit 200 and the second storage unit 300 move, the first guide protrusion 250 and the second guide protrusion 370 are initially engaged in the first obstruction area and the second obstruction area, and in order to move the first storage unit 200 and the second storage unit 300 further, the first storage unit 200 and the second storage unit 300 must be pressed downward, thereby preventing the first storage unit 200 and the second storage unit 300 from moving suddenly.

[0104] A structure for preventing the downward movement of the first storage section 200 before the reaction vessel is inserted into the heating device 10 will be described in detail below.

[0105] An operation prevention opening 180 that opens upward may be formed in the side wall of the body part 100 . For example, the actuation prevention opening 180 may be formed in a wall of the body part 100 on the fourth direction D4 side.

[0106] The first storage section 200 may include an actuation prevention member 270 . The actuation prevention member 270 can protrude from the body and be placed in the actuation prevention opening 180 . The actuation prevention member 270 is placed in the actuation prevention opening 180 and can prevent the first storage section 200 from moving downward.

[0107] As an example, the actuation preventing member 270 can include a first portion and a second portion. The first portion may be a portion that protrudes from the first storage body 210 toward the side wall of the body portion 100 . The second portion may be a portion that projects downward from the first portion and rests on the activation prevention opening 180. The actuation prevention member 270 may be elastic. The second portion can be released from the activation prevention opening 180 when pressed by an activation initiation protrusion 14 of the heating device 10, which will be described later.

[0108] Since the second portion is placed on the operation prevention opening 180, the first storage portion 200 connected to the second portion can be prevented from moving downward. However, when the activation protrusion 14 of the heating device 10 presses the second part inward, the second part is released from the activation prevention opening 180, and from that time on, the first storage part 200 can move downward.

[0109] The body portion 100 may include a first actuation opening 160 and a second actuation opening 170 . The first storage portion 200 may include a first actuation protrusion 260 . The second storage portion 300 may include a second actuation protrusion 380 . These are components for operating the heating device 10, and a detailed description will be given after the description of the heating device 10.

[0110] heating device 10 The heating device 10 according to the first embodiment will be described in detail below. FIG. 15 is a diagram illustrating a heating device 10 according to the first embodiment of the present invention. FIG. 16 is a diagram illustrating the heating device 10 according to the first embodiment of the present invention as viewed from above.

[0111] The heating device 10 may include a heating section 12 . The heating device 10 is in contact with the underside of the mixing section 400 and can heat the mixing space 401 . As an example, the heating unit 12 can be operated by externally supplied power. Alternatively, the heating unit 12 can be powered by a battery built into the heating device 10 .

[0112] The heating device 10 may include a first switch 13 . The first switch 13 can be provided so as to be pressurized by the underside of the reaction vessel when the reaction vessel is inserted into the insertion space 11, thereby activating the heating unit 12. For example, the first switch 13 may be electrically connected to the heating unit 12 by a control unit (not shown). When the first switch 13 is pressed, the control unit can activate the heating unit 12 .

[0113] The controller may include a processor and a memory. The processor may include a microprocessor such as a Field Programmable Gate Array (FPGA), an Application Specific Integrated Circuit (ASIC), or a Central Processing Unit (CPU). The memory can store control instructions that are the basis for generating instructions such as instructions for determining whether the heating unit 12 is activated by the processor. The memory may be a data store such as a hard disk drive (HDD), a solid state drive (SSD), a volatile medium, or a non-volatile medium.

[0114] The heating device 10 may include an activation protrusion 14 . The activation protrusion 14 can protrude from the surface defining the insertion space 11 toward the second portion. The activation protrusion 14 can pressurize the second part when the reaction vessel moves downward, and can separate it from the activation prevention opening 180. After the activation protrusion 14 disengages the second portion from the activation prevention opening 180, the user can move the first portion downward.

[0115] The body portion 100 may include a first actuation opening 160 and a second actuation opening 170 . The first operating opening 160 can open upward. For example, the first actuation opening 160 may be formed in a wall of the body part 100 on the fourth direction D4 side. The second actuation opening 170 is located on the first direction D1 side of the first actuation opening 160 and can open upward.

[0116] The first storage portion 200 may include a first actuation protrusion 260 . The first actuation protrusion 260 can be inserted into the first actuation opening 160 and protrude from the first storage body 210 through the first actuation opening 160 .

[0117] The second storage portion 300 may include a second actuation protrusion 380 . The second actuation protrusion 380 can be inserted into the second actuation opening 170 and protrude from the second storage body 310 through the second actuation opening 170 .

[0118] The heating device 10 may include a signal generator 15 , a second switch 16 and a third switch 17 . The signal generating unit 15 can be arranged to generate a predetermined signal to the user. As an example, the signal may be a sound. As another example, the signal may be light emitted via a light emitting device. As yet another example, the signal generating unit 15 may generate sound and light simultaneously.

[0119] The second switch 16 may be disposed at a position corresponding to the first actuation protrusion 260 . When the second switch 16 is pressed by the first actuation protrusion 260, it can actuate the signal generating unit 15 to generate a signal after a first reference time. The first reference time may be, but is not limited to, 20 minutes.

[0120] The third switch 17 may be disposed at a position corresponding to the second actuation protrusion 380 . When the third switch 17 is pressed by the second actuation protrusion 380, it can actuate the signal generating unit 15 to generate a signal after a second reference time. The second reference time may be a time between 7 and 10 minutes.

[0121] Based on the above description, the operation of the reaction vessel system according to the first embodiment will be described in detail below. The details explained when explaining the reaction vessel will be omitted.

[0122] First, the user collects a specimen using a collection tool.

[0123] Next, the user places the collected sample in the first storage section 200 and closes the first upper cover 230 to seal the first storage space 211 .

[0124] Next, the user inserts the reaction vessel into the insertion space 11 of the heating device 10 . Here, the actuation initiation protrusion 14 allows the first storage portion 200 to move downward. Furthermore, the first switch 13 can activate the heating unit 12 .

[0125] Next, the user moves the first storage section 200 downward. During this process, the second switch 16 is pressed, and after the first reference time, the signal generating unit 15 generates a signal.

[0126] After the first reference time has elapsed, the user moves the second storage section 300 downward. During this process, the third switch 17 is pressed, and after the second reference time, the signal generating unit 15 generates a signal.

[0127] Finally, the user can remove the reaction vessel and view the test results through the exposed area 190.

[0128] Embodiment 2 FIG. 17 is a perspective view illustrating a reaction vessel according to a second embodiment of the present invention. FIG. 18 is a view showing the state of FIG. 17 as viewed from another direction. FIG. 19 is an exploded perspective view of a reaction vessel according to a second embodiment of the present invention. FIG. 20 is a perspective view illustrating a swab. FIG. 21 is a cross-sectional view of a state in which a swab is placed in the first internal space of a reaction vessel according to the second embodiment of the present invention. FIG. 22 is a diagram illustrating the second storage section of the reaction vessel according to the second embodiment of the present invention. FIG. 23 is a view illustrating the second storage section of FIG. 22 as viewed from another direction. FIG. 24 is a diagram illustrating both the first and second locking openings. FIG. 25 is a diagram illustrating the first and second storage sections before they are moved downward. FIG. 26 is a diagram illustrating a state in which the first storage section in FIG. 25 has moved downward. FIG. 27 is a diagram illustrating a state in which the second storage section in FIG. 26 has moved downward.

[0129] A reaction vessel and a reaction vessel system according to a second embodiment of the present invention will be described below with reference to FIGS. The reaction vessel and reaction vessel system according to the second embodiment differ from the reaction vessel and reaction vessel system according to the first embodiment in the shape of the mixing section, the shape of the opening and the opening breaking member, the operation method of the heating device, and the like. The same or corresponding components as those in the reaction vessel and reaction vessel system according to embodiment 1 are given the same or corresponding reference numerals, and detailed descriptions thereof will be omitted.

[0130] reaction vessel The reaction vessel according to the second embodiment of the present invention may include a body portion 100', a first storage portion 200', a second storage portion 300', and a mixing portion 400'. The body portion 100' may have an exposed region 190' formed therein.

[0131] The mixing section 400 ′ may include a first angled portion 430 and a second angled portion 440 . The first inclined portion 430 may be formed to be inclined upward with respect to the first direction D1. The second inclined portion 440 may be formed to be inclined upward with respect to the first direction D1 and may be located on the first inclined portion 430 in the first direction D1. The second angled portion 440 may be less angled than the first angled portion 430 .

[0132] This may mean that liquid flowing along the second inclined portion 440 will flow to the first inclined portion 430 . It may also mean that the speed at which liquid flows along the second inclined portion 440 is slower than the speed at which liquid flows along the first inclined portion 430 .

[0133] The reaction liquid placed in the first storage space 211' may have higher viscosity than the developing liquid placed in the second storage space 311'. Therefore, the inclination of the first inclined portion 430 is made steeper than that of the second inclined portion 440, so that the reaction liquid can be guided to the sample more smoothly.

[0134] When viewed in the vertical direction, the first inclined portion 430 may include an area that overlaps with the first storage section 200'. This may mean that the first inclined portion 430 is a portion on which the reaction liquid that has fallen from the first storage space 211' is placed.

[0135] The second angled portion 440 may include an area that overlaps with the second storage section 300'. This may mean that the second inclined portion 440 is a portion on which the developing liquid that has fallen from the second storage space 311' is placed.

[0136] The mixing section 400 ′ may further include a mixing opening 450 . The mixing opening 450 communicates with the mixing space 401', is located on the opposite side of the first direction D1 of the first inclined portion 430, and may be a portion that opens upward. A buffer solution can be placed inside the mixing opening 450 . The mixing opening 450 may be a portion where the sample, reaction solution, buffer solution, and developing solution gather. The mixing opening 450 may also be a location where the lower end of the reaction detection unit 500' is placed when the reaction detection unit 500' moves downward.

[0137] The mixing section 400' may further include a first breaking member 410' and a second breaking member 420'. When viewed along the vertical direction, the first inclined portion 430 can include an area that overlaps with the first breaking member 410'. Additionally, when viewed in the vertical direction, the second inclined portion 440 may include an area that overlaps with the second breaking member 420'.

[0138] A waterproof member 600 for waterproofing may be disposed between the first storage unit 200' and the mixing unit 400' and between the second storage unit 300' and the mixing unit 400'. As an example, the waterproofing member 600 may be a waterproof tape. This is to prevent the contents from leaking between the first storage unit 200' and the mixing unit 400' or between the second storage unit 300' and the mixing unit 400'.

[0139] The first storage unit 200' of the reaction vessel according to the second embodiment may include a first storage unit body 210' and a first lower cover 220'.

[0140] The first storage section 200 ′ may further include a first obstructing portion 214 . The first obstructing portion 214 may protrude from the inner surface of the first storage body 210' toward the first storage space 211'. The first obstructing portion 214 may be a portion provided to obstruct the entry of collection tools to be put into the first storage space 211'.

[0141] As an example, the collection tool may be a swab 700 (Swab). The swab 700 can include a swab body 710, a swab projection 720, and a specimen collection portion 730 extending along an elongate direction. Swab projection 720 can project outward from swab body 710 . The specimen collection portion 730 can be coupled to the end of the swab body 710 opposite the extension direction.

[0142] Additionally, an incision 740 may be formed in the swab body 710 . The incision 740 may be formed on the extension side of the swab protrusion 720 . The distance between the incision portion 740 and the swab protrusion 720 may be shorter than the distance between the swab protrusion 720 and the specimen collection portion 730.

[0143] When the swab 700 is inserted into the first storage space 211', a portion of the swab body 710 located on the extension side of the incision 740 may be cut off. As an example, in the process of moving the first upper cover 230' in the first direction D1, the first upper cover 230' may pressurize the swab body 710, and the portion of the swab body 710 located on the extension side of the incision portion 740 may be cut. As yet another alternative, the user may apply force to the swab body 710 to cut the swab body 710 before moving the first top cover 230' in the first direction D1.

[0144] The first storage space 211 ′ may include an upper space located above the first obstructing portion 214 and a lower space located below the first obstructing portion 214 . The vertical length of the upper space may be shorter than the vertical length of the lower space. The upper space may be the space in which the area between the swab projection 720 and the incision 740 is located. The lower space may be the space in which the area between the specimen collection portion 730 and the swab protrusion 720 is located.

[0145] The first obstructing portion 214 obstructs the movement of the swab protrusion 720 and prevents the specimen collection portion 730 from entering too deeply, coming into contact with the first breaking member 410' and blocking the first input space 411'.

[0146] The second storage section 300' of the reaction vessel according to the second embodiment may include a second storage section body 310', a second lower cover 320' and a second upper cover 330'.

[0147] The second storage section 300' may further include an opening 340' and an opening cover 350'. The body portion 100' of the reaction vessel according to the second embodiment can include an opening rupture member 120'.

[0148] The opening 340' may be formed in a sidewall of the second storage body 310' and may have a shape that is inclined upward with respect to the first direction D1. When viewed in the vertical direction, the end of the opening breaking member 120' and the opening cover 350' can overlap each other. The end of the opening breaking member 120' can be configured to look upward. The aperture breaking member 120' can be disposed within the communication aperture 340'.

[0149] When viewed in the vertical direction, the end of the opening-breaking member 120' and the opening cover 350' overlap each other, and as the second storage section 300' moves downward, the end of the opening-breaking member 120' and the opening cover 350' can come into contact, and the opening-breaking member 120' can break the opening cover 350'.

[0150] The first storage section 200' may further include a first locking opening 240'. The first locking opening 240' is formed in the first storage body 210', opens upward, and can be opened along the first direction D1.

[0151] The second storage section 300' may further include a locking member 360'. The locking member 360' can protrude from the second storage body 310' and pass through the first locking opening 240' in a direction opposite to the first direction D1. The locking member 360' may be configured to prevent the second storage section 300' from moving downward before the first storage section 200' moves downward.

[0152] The locking member 360' may have a first locking opening 361 formed therein. The first locking opening 361 opens downward and can be opened along a direction perpendicular to the first direction D1. When the first storage section 200' and the second storage section 300' are positioned at the uppermost end or when the first storage section 200' and the second storage section 300' are positioned at the lowermost end, the area of ​​the first storage section body 210' that defines the first locking opening 240' and the area of ​​the locking member 360' that defines the first locking opening 361 can engage with each other.

[0153] By engaging the area of ​​the first storage body 210' that defines the first locking opening 240' with the area of ​​the locking member 360' that defines the first locking opening 361 with each other, the second storage section 300' can be prevented from moving along the first direction D1 or the second direction D2 relative to the first storage section 200', and the first storage section 200' can be prevented from moving along the third direction D3 or the fourth direction D4 relative to the second storage section 300'.

[0154] The reaction vessel may further include a reaction detection unit 500'. The reaction detection unit 500 ′ can be fitted at its upper end into the fitting opening 362 . The fitting opening 362 may be formed in a fitting region 363, which is a region of the locking member 360' located on the second direction D2 side of the first storage portion 200'. The mating opening 362 can open downward. The length of the fitting opening 362 along the second direction D2 may be equal to or less than the length of the reaction detection unit 500' along the second direction D2. This may be due to the tight fit of the reaction detection portion 500'.

[0155] The mating region 363 may further include a placement opening 364 . The placement opening 364 may be an opening 340' that opens toward the second direction D2 and in which the reaction detection unit 500' is placed.

[0156] The body portion 100 ′ may further include a pass-through portion 101 . The passage part 101 may be a part that opens at the top and bottom and is provided so as to surround part of the reaction detection part 500'. The passage portion 101 may be a structure that guides the vertical movement of the reaction detection unit 500'.

[0157] The structure for interaction with the heating device 10' according to the second embodiment, which will be described later, will be described in detail below.

[0158] The body portion 100' can include a first actuation opening 160' and a second actuation opening 170'. The first storage portion 200 ′ may include a first actuation protrusion 260 ′ and a first magnet 280 . A first magnet 280 may be coupled to the end of the first actuation protrusion 260'. The first magnet 280 may be a member that can be sensed by a second sensing member 16', which will be described later.

[0159] The second storage portion 300 ′ may include a second actuation protrusion 380 ′ and a second magnet 390 . A second magnet 390 may be coupled to the end of the second actuation protrusion 380'. The second magnet 390 may be a member that can be sensed by a third sensing member 17', which will be described later.

[0160] Additionally, the reaction vessel may further include an actuation protrusion 460 and an actuation magnet 470 . An actuation protrusion 460 may protrude downwardly from the underside of the mixing portion 400'. An actuation magnet 470 may be coupled to the end of the actuation projection 460 . The actuation magnet 470 may be a member that can be sensed by a first sensing member 13', which will be described later.

[0161] The operation of the reaction vessel according to the second embodiment of the present invention will be conceptually described in detail below with reference to the above content and drawings. The following describes in detail the case where the collection tool is a swab 700.

[0162] First, after collecting a sample with the swab 700, the user moves the first upper cover 230' in the second direction D2 and inserts the swab 700 into the first storage space 211'. The specimen collection portion 730 contacts the reaction liquid, and the swab protrusion 720 is engaged with the first obstruction portion 214 . The sample is allowed to react with the reaction solution.

[0163] Next, the user moves the first upper cover 230' in the first direction D1. During this process, an external force may be applied to the incision portion 740, causing the swab body 710 to be cut.

[0164] Next, the user moves the first storage section 200' downward. During this process, the first lower cover 220 ′ is broken, and the reaction solution and the specimen in the first storage space 211 ′ move to the mixing space 401 ′ and are placed on the first inclined portion 430 . The reaction mixture and the specimen placed on the first inclined portion 430 move along the inclination to the mixing opening 450 . During this process, the buffer solution, reaction solution, and specimen present in the mixing space 401' can be mixed. This may be the situation shown in FIG.

[0165] Next, the user moves the second storage section 300' downward. During this process, the second lower cover 320 ′ and the opening cover 350 ′ are broken, and the developing liquid in the second storage space 311 ′ moves to the mixing space 401 ′ and is placed on the second inclined portion 440 . The developer placed on the second inclined portion 440 moves along the slope through the first inclined portion 430 to the mixing opening 450, thereby forming a mixed reactant. During this process, the reaction detecting unit 500' moves downward together with the second storage unit 300', and the reaction detecting unit 500' comes into contact with the mixed reactant located in the mixing opening 450, thereby detecting the reaction. This may be the situation shown in FIG.

[0166] As an example, the above-mentioned operation may be performed before the reaction vessel is inserted into the insertion space 11' of the heating device 10'.

[0167] heating device 10' The heating device 10' according to the second embodiment will be described in detail below with reference to FIGS. FIG. 28 is a diagram illustrating a heating device according to a second embodiment of the present invention. FIG. 29 is a diagram illustrating a heating device according to a second embodiment of the present invention as viewed from above. FIG. 30 is a diagram illustrating a state in which a reaction vessel is disposed inside a heating device according to the second embodiment of the present invention. FIG. 31 is a diagram illustrating the sequence of operations of the reaction vessel system according to the second embodiment of the present invention. For reference, in FIG. 30, for convenience of explanation, a part of the heating device 10' is shown in perspective.

[0168] The heating device 10' can include a heating section 12'. The heating section 12 ′ can be configured to contact the area of ​​the mixing section 400 ′ that defines the mixing opening 450 and heat the mixing opening 450 . Heating the mixing opening 450 can thaw the buffer solution that was frozen.

[0169] The heating section 12' may include a temperature sensor. A temperature sensor can be provided to measure the temperature of the heating section 12'. The heating section 12' can be configured to maintain a reference temperature based on the temperature measured by the temperature sensor. As an example, the reference temperature may be between 60 and 70 degrees Celsius.

[0170] The heating device 10' may include a signal generating section 15'. After the heating unit 12' has completed preheating for a predetermined time, the signal generating unit 15' can generate a signal to insert the reaction vessel into the insertion space 11'.

[0171] The heating section 12' may include a first sensing member 13'. The first sensing member 13' can sense the actuation magnet 470 when the reaction vessel is inserted into the insertion space 11'. As an example, the first sensing member 13' can sense the actuation magnet 470 based on an induced current that occurs as the actuation magnet 470 moves closer or further away. When the first sensing member 13' senses the actuation magnet 470, it can activate the signal generating unit 15' to generate a signal to move the first storage unit 200' downward.

[0172] Also, when the first sensing member 13' senses that the actuating magnet 470 has been removed, it can activate the signal generating unit 15' to generate a signal to prompt the user to insert a reaction vessel again.

[0173] The heating section 12' can include a second sensing member 16'. The second sensing member 16' is disposed at a position corresponding to the first actuating protrusion 260', and when it senses the first magnet 280, it can activate the signal generating unit 15' to generate a signal after a first reference time. The signal at this time may be a signal to move the second storage unit 300' downward. As an example, the second sensing member 16' can sense the first magnet 280 based on an induced current that occurs when the first magnet 280 approaches or moves away.

[0174] The heating section 12' may include a third sensing member 17'. The third sensing member 17' is disposed at a position corresponding to the second actuating protrusion 380', and when it senses the second magnet 390, it can activate the signal generating unit 15' to generate a signal after a second reference time. The signal at this time may be a signal indicating that the test has been completed.

[0175] As an example, the third sensing member 17' can sense the second magnet 390 based on an induced current that occurs as the second magnet 390 approaches or moves away.

[0176] The heating section 12 ′ can include a first light-emitting member 18 and a second light-emitting member 19 . The first light-emitting member 18 may be turned on when the first sensing member 13 ′ senses the actuation magnet 470 . The first light emitting member 18 may be turned off after the second sensing member 16 ′ senses the first magnet 280 . The first light-emitting member 18 may be disposed adjacent to the second sensing member 16'.

[0177] The second light emitting member 19 may be turned on after a first reference time has elapsed since the second sensing member 16 ′ senses the first magnet 280 . The second light emitting member 19 may be turned off after the third sensing member 17' senses the second magnet 390. The second light-emitting member 19 may be disposed adjacent to the third sensing member 17'.

[0178] As an example, the signal generating unit 15', the first light emitting member 18 and the second light emitting member 19 may be electrically connected to the first sensing member 13', the second sensing member 16' and the third sensing member 17' via the control unit.

[0179] Based on the above description, the operation of the reaction vessel system according to the second embodiment will be described in detail below. The details explained when explaining the reaction vessel will be omitted.

[0180] First, the user collects a sample with the swab 700.

[0181] Next, the user places the collected sample in the first storage section 200' and closes the first upper cover 230' to seal the first storage space 211'.

[0182] The user then connects power to the heating device 10'. Here, the heating section 12' can be activated and preheated. However, the process of preheating the heating device 10' by connecting it to a power source may be performed prior to the sample collection process.

[0183] Next, the user inserts the reaction vessel into the insertion space 11' of the heating device 10'. As a result, the heating unit 12' heats and dissolves the buffer solution located in the mixing opening 450. Here, the first sensing member 13 ′ can sense the actuation magnet 470 . When the first sensing member 13' senses the actuation magnet 470, it can activate the signal generating unit 15' to generate a signal to move the first storage unit 200' downward.

[0184] Next, the user moves the first storage section 200' downward. During this process, the second sensing member 16' senses the first magnet 280 and activates the signal generating unit 15' to generate a signal to move the second storage unit 300' downward after a first reference time.

[0185] Next, the user moves the second storage section 300' downward. During this process, the third sensing member 17' senses the second magnet 390 and activates the signal generating unit 15' to generate a signal indicating that the test has been completed after a second reference time. The signal at this time may be a signal indicating that the test has been completed.

[0186] Finally, the user can remove the reaction vessel and view the test results through the exposed area 190'.

[0187] The above description is merely an illustrative example of the technical concept of the present invention, and various modifications and variations may be made by a person having ordinary knowledge in the technical field to which the present invention pertains without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are for illustrative purposes only and do not limit the technical idea of ​​the present invention, and the scope of the technical idea of ​​the present invention is not limited by such embodiments. The scope of protection of the present invention should be interpreted by the following claims, and all technical ideas within the scope equivalent thereto should be interpreted as being included in the scope of the present invention.

Claims

1. The body part and a first storage section disposed within the body section, movable in a vertical direction, and including a first storage space therein; a second storage section disposed within the body section, movable in a vertical direction, including a second storage space therein, and disposed on a first direction side, which is one of left and right directions, based on the first storage section; a mixing unit including a mixing space that communicates with the first storage space when the first storage unit is positioned at the lowest end and communicates with the second storage space when the second storage unit is positioned at the lowest end; a reaction detection unit having a lower end that contacts the mixed reactant located in the mixing space and then reacts with the mixed reactant to produce a detection reaction.

2. the first storage section includes a first storage section body defining the first storage space that is open at the top and bottom, and a first lower cover coupled to a lower portion of the first storage section body to cover a lower portion of the first storage space, the mixing section includes a first breakable member defining a first input space communicating with the mixing space and extending above the mixing space; The reaction vessel according to claim 1 , wherein the first breaking member is configured to penetrate the first lower cover to communicate the first storage space with the first input space when the first storage section moves downward.

3. 2. The reaction vessel according to claim 1, wherein the first storage unit further includes a first storage unit body defining the first storage space that is open at the top and bottom, and a first upper cover coupled to an upper portion of the first storage unit body to open and close an upper portion of the first storage space.

4. an upper portion of the first storage body is formed to be inclined upward with respect to the first direction; The reaction vessel according to claim 3 , wherein the first top cover has a shape corresponding to the top of the first storage body.

5. 5. The reaction vessel according to claim 4, wherein the first upper cover is slidably connected to the upper part of the first storage body in the left-right direction, opens the upper part of the first storage space when moving in a second direction opposite to the first direction, and closes the upper part of the first storage space when moving in the first direction.

6. the second storage section includes a second storage section body defining the second storage space that is open at the top and bottom, and a second lower cover coupled to a lower portion of the second storage section body to cover a lower portion of the second storage space, the mixing section includes a second breakable member defining a second input space communicating with the mixing space and extending above the mixing space; The reaction vessel according to claim 2 , wherein the second breaking member is configured to penetrate the second lower cover to communicate the second storage space with the second input space when the second storage section moves downward.

7. the second storage unit further includes an opening formed in an upper portion of the second storage unit body and an opening cover provided to close the opening, The reaction vessel according to claim 6 , wherein the body portion includes an opening breaking member that breaks the opening cover to open the opening when the second storage portion moves downward.

8. The opening is formed in a side wall of the second storage body, the opening breaking member contacts a lower surface of the second storage body in a region that defines the opening and supports the second storage body upward; a surface of the opening breaking member that contacts the second storage body is formed as an inclined surface; The reaction vessel according to claim 7, wherein the opening breaking member moves so that an end facing the second storage body contacts the second storage body when the second storage body moves downward, elastically supporting the second storage body, and then contacts the opening cover.

9. the body portion further includes a communication opening formed in a wall corresponding to the position of the opening when the second storage portion body is moved downward; The reaction vessel according to claim 7 , wherein the opening-breaking member is disposed within the communication opening.

10. the first storage section includes a first storage section body that defines the first storage space and that opens upward and downward, and a locking opening that is formed in the first storage section body and that opens upward, The reaction vessel according to claim 1 , wherein the second storage section includes a second storage section body that defines the second storage space that opens upward and downward, and a locking member that protrudes from the second storage section body and passes through the locking opening.

11. the reaction detection unit is connected to the second storage unit by the locking member and is movable in the up and down direction; The reaction vessel according to claim 10 , which is disposed on a second direction side of the first storage section, which is opposite to the first direction.

12. the body portion includes a first guide opening formed on a wall of the body portion on a third direction side perpendicular to the up-down direction and the first direction, the first guide opening opening upward, and a second guide opening located on the first direction side of the first guide opening opening upward, the first storage section includes a first storage section body defining the first storage space that is open at the top and bottom, and a first guide protrusion that protrudes from the first storage section body in the third direction and is inserted into the first guide opening, 2. The reaction vessel of claim 1, wherein the second storage section includes a second storage section body that defines the second storage space that opens upward and downward, and a second guide protrusion that protrudes from the second storage section body in the third direction and is inserted into the second guide opening.

13. The first guide opening includes a first obstructing region having a width narrower than a diameter of the first guide protrusion and obstructing downward movement of the first guide protrusion, The reaction vessel of claim 12 , wherein the second guide opening includes a second obstruction region that is narrower than a diameter of the second guide protrusion and obstructs downward movement of the second guide protrusion.

14. An operation prevention opening that opens upward is formed in a side wall of the body portion, the first storage section includes a first storage section body that defines the first storage space and that opens upward and downward, and an actuation prevention member that protrudes from the first storage section body and is placed in the actuation prevention opening, 2. The reaction vessel according to claim 1, wherein the activation prevention member includes a first portion that protrudes from the first storage body toward the side wall of the body portion, and a second portion that protrudes downward from the first portion and is placed on the activation prevention opening.

15. The reaction vessel according to claim 1 , wherein a surface of the mixing section that defines a lower portion of the mixing space is inclined upward with respect to the first direction.

16. A freeze-dried buffer solution is placed in the mixing space, A reaction solution configured to react with a sample collected from a user is placed in the first storage space, a developing solution is disposed in the second storage space, the developing solution being provided so as to develop the reaction solution mixed with the buffer solution in the reaction detection unit; The reaction vessel of claim 1 , wherein the buffer solution comprises an enzyme and a primer.

17. a reaction vessel; and a heating device that is provided so that the reaction vessel is inserted into an internal insertion space and that heats the underside of the reaction vessel; The reaction vessel system includes a body portion, a first storage portion disposed within the body portion, movable in the vertical direction, and including a first storage space therein, a second storage portion disposed within the body portion, movable in the vertical direction, and including a second storage space therein, and a mixing portion including a mixing space that communicates with the first storage space when the first storage portion is positioned at the lowest end and that communicates with the second storage space when the second storage portion is positioned at the lowest end.

18. 18. The reaction vessel system according to claim 17, wherein the heating device includes a heating section that contacts the underside of the mixing section to heat the mixing space, and a first switch that is pressurized by the underside of the reaction vessel when the reaction vessel is inserted into the insertion space to activate the heating section.

19. An operation prevention opening that opens upward is formed in a side wall of the body portion, the first storage section includes a first storage section body that defines the first storage space and that opens upward and downward, and an actuation prevention member that protrudes from the first storage section body and is placed in the actuation prevention opening, the actuation prevention member includes a first portion that protrudes from the first storage body toward the side wall of the body portion, and a second portion that protrudes downward from the first portion and is placed in the actuation prevention opening, The reaction vessel system of claim 18, wherein the heating device includes an activation initiation protrusion that protrudes from a surface defining the insertion space toward the second portion and presses the second portion to remove it from the activation prevention opening when the reaction vessel moves downward.

20. the body portion includes a first actuation opening that opens upward and a second actuation opening that opens upward; the first storage section includes a first storage section body defining the first storage space that is open at the top and bottom, and a first actuation protrusion that is inserted into the first actuation opening and protrudes from the first storage section body through the first actuation opening, the second storage section includes a second storage section body defining the second storage space that is open at the top and bottom, and a second actuation protrusion that is inserted into the second actuation opening and protrudes from the second storage section body through the second actuation opening, 19. The reaction vessel system according to claim 18, wherein the heating device includes: a signal generating unit configured to generate a predetermined signal to a user; a second switch disposed at a position corresponding to the first actuating protrusion, the second switch configured to activate the signal generating unit to generate the signal after a first reference time when the heating device is pressurized by the first actuating protrusion; and a third switch disposed at a position corresponding to the second actuating protrusion, the third switch configured to activate the signal generating unit to generate the signal after a second reference time when the heating device is pressurized by the second actuating protrusion.

21. a body part; a first storage part disposed within the body part, movable in the vertical direction, and including a first storage space therein; a second storage part disposed within the body part, movable in the vertical direction, including a second storage space therein, and disposed on a first direction side, which is one of left and right directions, with respect to the first storage part; and a mixing part including a mixing space that communicates with the first storage space when the first storage part is located at the lowest end and communicates with the second storage space when the second storage part is located at the lowest end, The mixing section includes a first inclined portion formed to be inclined upward with respect to the first direction, and a second inclined portion formed to be inclined upward with respect to the first direction, located in the first direction of the first inclined portion, and having a smaller degree of inclination than the first inclined portion.

22. When viewed in the vertical direction, the first inclined portion includes an area that overlaps with the first storage portion, 22. The reaction vessel of claim 21, wherein the second sloped portion includes an area that overlaps with the second storage section.

23. the first storage section includes a first storage section body defining the first storage space that is open at the top and bottom, and a first lower cover coupled to a lower portion of the first storage section body to cover a lower portion of the first storage space, the mixing section includes a first breakable member defining a first input space communicating with the mixing space and extending above the mixing space; The reaction vessel according to claim 21 , wherein the first breaking member is configured to penetrate the first lower cover to communicate the first storage space with the first input space when the first storage part moves downward.

24. 24. The reaction vessel of claim 23, wherein the first storage section further includes a first obstruction portion that protrudes from an inner surface of the first storage section body toward the first storage space and is configured to obstruct the entry of collection tools inserted into the first storage space.

25. The first storage space includes an upper space located above the first obstructing portion and a lower space located below the first obstructing portion, The reaction vessel according to claim 24, wherein the upper space has a length in the vertical direction that is shorter than the length in the vertical direction of the lower space.

26. the second storage section includes a second storage section body defining the second storage space that is open at the top and bottom, and a second lower cover coupled to a lower portion of the second storage section body to cover a lower portion of the second storage space, the mixing section includes a second breakable member defining a second input space communicating with the mixing space and extending above the mixing space; The reaction vessel according to claim 23, wherein the second breaking member is configured to penetrate the second lower cover to communicate the second storage space with the second input space when the second storage part moves downward.

27. the second storage section further includes an opening formed in an upper portion of the second storage section body, and an opening cover provided to close the opening, 27. The reaction vessel according to claim 26, wherein the body portion includes an opening breaking member configured to break the opening cover when the second storage portion moves downward.

28. the opening is formed in a side wall of the second storage body and has a shape that is inclined upward with respect to the first direction; 28. The reaction vessel according to claim 27, wherein the end of the opening-breaking member and the opening cover overlap each other when viewed in the vertical direction.

29. 30. The reaction vessel of claim 28, wherein the end of the opening-breaking member faces upward.

30. the first storage portion further includes a first latching opening formed in the first storage portion body, opening upward and along the first direction; 27. The reaction vessel according to claim 26, wherein the second storage section further includes a locking member protruding from the second storage section body and passing through the first locking opening in a direction opposite to the first direction.

31. The locking member has a second locking opening that opens downward and along a direction perpendicular to the first direction, 31. The reaction vessel of claim 30, wherein when the first storage section and the second storage section are positioned at the uppermost end or when the first storage section and the second storage section are positioned at the lowermost end, the region of the first storage section body defining the first locking opening and the region of the locking member defining the second locking opening engage with each other.

32. a reaction detection unit having a lower end that contacts the mixed reactant positioned in the mixing space and reacts with the mixed reactant to produce a detection reaction; The reaction vessel of claim 30, wherein the reaction detection unit has an upper end that fits into a fitting opening that opens downward and is formed in a fitting region, which is a region of the locking member located on a second direction side that is opposite the first direction of the first storage unit.

33. The reaction vessel according to claim 32 , wherein the fitting region further includes a placement opening that opens toward the second direction and in which the reaction detection unit is placed.

34. 33. The reaction vessel according to claim 32, wherein the body portion further includes a passage portion that opens upward and downward and is provided so as to surround a part of the reaction detection portion.

35. the body portion includes a first operating opening that opens upward and a second operating opening that opens upward and is located in the first direction of the first operating opening, the first storage section includes a first storage section body defining the first storage space that is open at the top and bottom, a first actuation protrusion inserted into the first actuation opening and protruding from the first storage section body through the first actuation opening, and a first magnet coupled to an end of the first actuation protrusion, 22. The reaction vessel of claim 21, wherein the second storage section includes a second storage section body defining the second storage space that is open at the top and bottom, a second actuation protrusion inserted into the second actuation opening and protruding from the second storage section body through the second actuation opening, and a second magnet coupled to an end of the second actuation protrusion.

36. 22. The reaction vessel according to claim 21, further comprising an actuation protrusion protruding downward from the lower surface of the mixing portion, and an actuation magnet coupled to an end of the actuation protrusion.

37. 22. The reaction vessel according to claim 21, wherein the mixing section further includes a mixing opening that communicates with the mixing space, is located on a side of the first inclined portion opposite to the first direction, and opens upward.

38. a reaction vessel; and a heating device that is provided so that the reaction vessel is inserted into an internal insertion space and that heats the underside of the reaction vessel; The reaction vessel includes a body portion, a first storage portion disposed within the body portion and movable in a vertical direction, the first storage portion including a first storage space therein, a second storage portion disposed within the body portion and movable in a vertical direction, the second storage portion including a second storage space therein, and the second storage portion being disposed on a first direction side, which is one of left and right directions, with the first storage portion as a reference, and a mixing portion including a mixing space that communicates with the first storage space when the first storage portion is positioned at the lowest end and communicates with the second storage space when the second storage portion is positioned at the lowest end, The mixing section includes a first inclined portion formed with an upward inclination with respect to the first direction, and a second inclined portion formed with an upward inclination with respect to the first direction, located in the first direction of the first inclined portion, and having a smaller inclination degree than the first inclined portion.

39. The mixing unit further includes an actuation protrusion protruding downward from a lower surface thereof, and an actuation magnet coupled to an end of the actuation protrusion, the mixing section further includes a mixing opening that communicates with the mixing space, is located on a side of the first inclined portion opposite to the first direction, and opens upward; 39. The reaction vessel system of claim 38, wherein the heating device includes a heating portion configured to contact a region of the mixing portion defining the mixing opening and heat the mixing opening, and a first sensing member configured to sense the actuating magnet when the reaction vessel is inserted into the insertion space.

40. the body portion includes a first operating opening that opens upward and a second operating opening that opens upward and is located in the first direction of the first operating opening, the first storage section includes a first storage section body defining the first storage space that is open at the top and bottom, a first actuation protrusion inserted into the first actuation opening and protruding from the first storage section body through the first actuation opening, and a first magnet coupled to an end of the first actuation protrusion, the second storage section includes a second storage section body defining the second storage space that is open at the top and bottom, a second actuation protrusion inserted into the second actuation opening and protruding from the second storage section body through the second actuation opening, and a second magnet coupled to an end of the second actuation protrusion, 40. The reaction vessel system of claim 39, wherein the heating device further includes a signal generating unit configured to generate a predetermined signal to a user, a second sensing member disposed at a position corresponding to the first actuating protrusion and activating the signal generating unit to generate the signal after a first reference time when the first magnet is detected, and a third sensing member disposed at a position corresponding to the second actuating protrusion and activating the signal generating unit to generate the signal after a second reference time when the second magnet is detected.

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