Ionizable cationic lipid compounds for the delivery of bioactive agents

Ionizable cationic lipids with branched tails in lipid nanoparticles address the challenges of nucleic acid delivery by enhancing endosomal lysis and conical morphology, leading to improved intracellular delivery and therapeutic efficacy.

JP2026517772APending Publication Date: 2026-06-02SHANGHAI VITALGEN BIOPHARMA CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
SHANGHAI VITALGEN BIOPHARMA CO LTD
Filing Date
2024-06-28
Publication Date
2026-06-02

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Abstract

This disclosure relates to novel lipid compounds for targeting and delivering one or more biologically active molecules. This application also relates to compositions or nanoparticles comprising such lipid compounds, methods for preparing such lipid compounds, methods for using such lipid compounds, and uses of such lipid compounds.
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