Novel benzamide derivative compounds and pharmaceutical compositions containing the same

Abstract

The present invention relates to novel benzimide compounds, their stereoisomers, pharmaceutically acceptable salts thereof, or their hydrates or solvates, the novel compounds exhibiting NAMPT inhibitory activity and capable of suppressing NAMPT to exhibit preventive or therapeutic effects against treatable diseases, and can effectively prevent or treat cancer.

Claims

1. Benzamide derivative compounds represented by the following chemical formula I, their stereoisomers, pharmaceutically acceptable salts thereof, or their hydrates or solvates: 【Chemistry 1】 In the aforementioned chemical formula I, R １ is a 6- to 14-membered aryl; C2-C8 hetecycloalkenyl; or a 5- to 12-membered heteroaryl, and the R １ -H is not substituted, or one or more H are halogens, NRaRb, NO ２ , or it may be substituted with OH; L １ It is a C1-C6 alkylene; L ２ is a single bond; or a C2-C6 alkynylene; X is a 6- to 14-membered arylene; C2-C8 heterocycloalkenylene; or a 5- to 12-membered heteroarylene, in which case one or more -H of X is unsubstituted, or one or more H of X is C1-C6 alkyl, CF ３ The X may be substituted with a halogen, a -C1-C6 alkoxy, or an OH group, and the -CH of X may be substituted. ２ - is either not substituted or one or more -CH of X ２ Each of the hyphens may be independently substituted with -(C=O)-, L ３ is a single bond; C1-C6 alkylene; C2-C6 alkenylene; C=O; (C=O)NRc; (C=O)NRd-(C1-C6 alkylene); NRy(C=O)-(C1-C6 alkylene); or O(C=O)-(C1-C6 alkylene); R ２ H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, C1-C8 heterocycloalkyl, -NRz １ Rz ２ , a 6- to 14-membered aryl or a 5- to 12-membered heteroaryl, and the R ２ The -H is either unsubstituted or one or more -H are C1-C6 alkyl, OH, COOH, (C1-C6 alkylene)-NReRf, NRgRh, NO ２ CF ３ , may be substituted with (C=O)NRiRj or halogen; L ４ These are single bonds, C1-C6 alkylenes, -NRm-(C1-C6 alkylene)-, or NRn; R ３ is H, C1-C6 alkyl, C3-C8 cycloalkyl, 6- to 14-membered aryl, C1-C8 heterocycloalkyl, C2-C8 heterocycloalkenyl, 5- to 12-membered heteroaryl, 6- to 14-membered arylene-C1-C8 heterocycloalkyl, 6- to 14-membered arylene-5- to 12-membered heteroaryl, 5- to 12-membered heteroarylene-6- to 14-membered aryl, 5- to 12-membered heteroarylene-C1-C8 heterocycloalkyl, or 5- to 12-membered heteroarylene-5- to 12-membered heteroaryl, and the R ３ The -H is either unsubstituted or one or more -H may be substituted with C1-C6 alkyl, C1-C6 alkoxy, phenoxy, OH, (C1-C6 alkylene)-OH, COOH, (C1-C6 alkylene)-COOH, (C1-C6 alkylene)-CN, NRoRp, (C1-C6 alkylene)-NRqRr, (C=O)-(C1-C6 alkyl), (C=O)-(C3-C8 cycloalkyl), (C=O)-(6- to 14-membered aryl), 6- to 14-membered aryl, 6- to 14-membered heteroaryl, 6- to 14-membered heterocycloaryl, halogen, (C=O)NRsRt, (C=O)-(C1-C6 alkyl)-NRuRv, NRwRx, (C=O)O-(C1-C6 alkyl), NO ２ CHF ２ CF ３ OCF ３ , or may be replaced by halogen, the R ３ -CH ２ The hyphen may either not be substituted or may be substituted with -(C=O)-. Said Ra~Rj, Rm~Ry, Rz １ and Rz ２ Each of these is independently either H or a C1-C6 alkyl group.

2. The aforementioned R １ These are aryls with 6 to 14 members; N, O, S, S(=O), and S(=O). ２ A C2-C8 heterocycloalkenyl comprising one or more heteroatoms or heterofunctional groups selected from the group consisting of; or a 5- to 12-membered heteroaryl comprising one or more heteroatoms selected from the group consisting of N, O, and S, in which case the R １ The -H atoms are either not substituted, or one or more H atoms are independently halogen, -NRaRb, and -NO. ２ Alternatively, it may be substituted with -OH. L １ It is a C1-C6 alkylene, L ２ is a single bond; or C2-C6 alkynylene, X is a 6- to 14-member allirene; N, O, S, S(=O), and S(=O) ２ A C2-C8 heterocycloalkenylene containing one or more heteroatoms or heterofunctional groups selected from the group consisting of; or a 5- to 12-membered heteroarylene containing one or more heteroatoms selected from the group consisting of N, O, and S, in which case the -H of X is unsubstituted, or if X is a 6- to 14-membered arylene or C2-C8 heterocycloalkenylene, then one or more -H are independently C1-C6 alkyl, -CF ３ It may be substituted with a halogen, a -C1-C6 alkoxy, or OH, and if X is a C2-C8 heterocycloalkenylene, -CH ２ - is either not substituted or has at least one -CH ２ The - can be substituted with -(C=O)-, L ３ These are single bonds; C1-C6 alkylene; C2-C6 alkenylene; -C=O; -C(=O)NRc; -C(=O)NRd-(C1-C6 alkylene); -NRyC(=O)-(C1-C6 alkylene); -NHC(=O); or -OC(=O)-(C1-C6 alkylene), R ２ H; halogen; -NRz １ Rz ２ C1-C6 alkyl; C1-C6 alkoxy; C3-C8 cycloalkyl; N, O, S, SO and SO ２ A C1-C8 heterocycloalkyl comprising one or more heteroatoms or heterofunctional groups selected from the group consisting of; a 6- to 14-membered aryl or a 5- to 12-membered heteroaryl comprising one or more heteroatoms selected from the group consisting of N, O and S, in which case the R ２ -H is either not substituted or R ２ One or more of the -H groups are independently -C1-C6 alkyl, -C1-C6 alkoxy, -OH, -COOH, -(C1-C6 alkylene)-NReRf, -NRgRh, -NO ２ , -CF ３ , may be substituted with -C(=O)NRiRj or halogen, L ４ is a single bond; -C1-C6 alkylene-; -NRm-(C1-C6 alkylene)-; or -NRn-, in which case L ４ -H is either not substituted or R ２ One or more of the -H atoms may be independently substituted with -C1-C6 alkyl groups. R ３ These are H; C1-C6 alkyl; C3-C8 cycloalkyl; 6- to 14-membered aryl; N, O, S, SO and SO ２ C1-C8 heterocycloalkyl groups comprising one or more heteroatoms or heterofunctional groups selected from the group consisting of N, O, S, SO and SO ２ C2-C8 heterocycloalkenyl comprising one or more heteroatoms or heterofunctional groups selected from the group consisting of; 5- to 12-membered heteroaryl comprising one or more heteroatoms selected from the group consisting of N, O, and S; 6- to 14-membered arylene-C1-C8 heterocycloalkyl (wherein the heterocycloalkyl is N, O, S, SO and SO ２ (containing one or more heteroatoms or heterofunctional groups selected from the group consisting of ); 6- to 14-membered arylene-5- to 12-membered heteroaryl (where the heteroaryl contains one or more heteroatoms selected from the group consisting of N, O, and S); 5- to 12-membered heteroarylene-6- to 14-membered aryl (where the heteroarylene contains one or more heteroatoms selected from the group consisting of N, O, and S); 5- to 12-membered heteroarylene-C1-C8 heterocycloalkyl (where the heteroarylene may contain one or more heteroatoms selected from the group consisting of N, O, and S, and the heterocycloalkyl contains N, O, S, SO, and SO ２ (containing one or more heteroatoms or heterofunctional groups selected from the group consisting of ); or a 5-membered to 12-membered heteroarylene-5-membered to 12-membered heteroaryl (where the heteroarylene or heteroaryl contains one or more heteroatoms selected from the group consisting of N, O and S), in which case the R ３ -H is either not substituted or R ３ One or more H atoms are independently -C1-C6 alkyl, -C1-C6 alkoxy, -phenoxy, -OH, -(C1-C6 alkylene)-OH, -COOH, -(C1-C6 alkylene)-COOH, (C1-C6 alkylene)-CN, -NRoRp, (C1-C6 alkylene)-NRqRr, -C(=O)-(C1-C6 alkyl), -C(=O)-(C3-C8 cycloalkyl), -C(=O)-(6- to 14-membered aryl), -NO ２ ,-CHF ２ , -CF ３ , -OCF ３ , 6- to 14-membered heteroaryl, N, O, S, SO and SO containing one or more heteroatoms selected from the group consisting of 6- to 14-membered aryls, N, O, and S ２ A 6- to 14-membered heterocycloaryl, -C(=O)NRsRt (wherein -C(=O)NRsRt, -H is either unsubstituted or one or more -H are independently substituted with halogens), -C(=O)-(C1-C6 alkylene)-NRuRv, -NRwRx, or may be substituted with halogens, R ３ If it is a heterocycloalkenyl, then -CH ２ - is either not substituted or one or more -CH ２ Each of the hyphens may be independently substituted with -(C=O)-, Said Ra~Rj, Rm~Ry, Rz １ and Rz ２ In either case, each may independently be H or a C1-C6 alkyl group. The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

3. R １ teeth, 【Chemistry 2】 And, R １ -H is either not substituted or R １ One or more H atoms are, independently, halogen, -NRaRb, and -NO ２ Alternatively, it may be substituted with -OH, where Ra and Rb are independently -H or C1-C6 alkyl. The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

4. R １ -H is either not substituted or R １ One or more of these -Hs are, independently, -NH ２ , -NO ２ , - NHCH ３ , -N(CH ３ ) ２ , or may be substituted with -OH, The benzamide derivative compound represented by chemical formula I as described in claim 3, its stereoisomer, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

5. L １ is methylene (-CH ２ -), ethylene (-CH ２ CH ２ -), n-propylene (-CH ２ CH ２ CH ２ -), isopropylene (-CHCH ３ CH ２ ), n-butylene (-CH ２ CH ２ CH ２ CH ２ -), sec-butylene (-CHCH ３ CH ２ CH ２ -), isobutylene (-CH ２ CHCH ３ CH ２ -), n-butylene (-CH ２ CH ２ CH ２ CH ２ -), sec-butylene (-CHCH ３ CH ２ CH ２ -), tert-butylene (-CCH ３ CH ３ CH ２ -), n-pentylene (-CH ２ CH ２ CH ２ CH ２ CH ２ -), or n-hexylene (-CH ２ CH ２ CH ２ CH ２ CH ２ CH ２ -), The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

6. L ２ is a single bond or ethynylene, 【Transformation 3】 ) The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

7. X is, 【Chemistry 4】 And, In this case, -H of X is not substituted, or X is 【Transformation 5】 In this case, -H is either unsubstituted or one or more -H are independently C1-C6 alkyl, halogen, -C1-C6 alkoxy, -OH, or -CF ３ It may be replaced with, and X is 【Transformation 6】 If that is the case, -CH ２ - is not substituted, or at least one -CH ２ Each of the hyphens can be independently substituted with -(C=O)-. A benzamide derivative compound represented by chemical formula I as described in claim 1 or 2, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.

8. L ３ This can be a single bond; C1-C6 alkylene; C2-C6 alkenylene; -(C=O)-; -(C=O)-NRc-; -C(=O)NRd-(C1-C6 alkylene)-; -NRyC(=O)-(C1-C6 alkylene); -NHC(=O); or -O(C=O)-(C1-C6 alkylene), where Rc, Rd or Ry are each independently -H or C1-C6 alkyl. The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

9. L ３ is a single bond; -(CH ２ )-;-(CH ２ ) ２ -;- (CH ２ ) ３ -;- (CH ２ ) ４ -;- (CH ２ ) ５ -;-(C=O)-NH(CH ２ )n;-NH(C=O)-;-NH(C=O)-(CH ２ )m;-(C=O)NH-;-(CH=CH)-CH ２ -;-O(C=O)CH ２ ; or -(C=O)-, where n and m are independently 1, 2, 3 or 4, The benzamide derivative compound represented by chemical formula I as described in claim 8, its stereoisomer, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

10. The aforementioned R ２ H; halogen; C1-C6 alkyl; C1-C6 alkoxy; -OH; -NH ２ ; 【Transformation 7】 And, At this time, the R ２ -H is either not substituted or R ２ One or more of the -H atoms are, independently, halogens, -C1-C6 alkoxys, and -NH ２ -OH, -CF ３ , -NO ２ -C1-C6 alkyl, -(CH ２ ) ３ -NH ２ ,-(CH ２ ) ２ -NH ２ ,-(CH ２ )-NH ２ , -(C=O)NH ２ , - NHCH ３ ,-NHCH(CH ３ ) ２ Alternatively, it may be substituted with -COOH. The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

11. L ４ is a single bond; -C1-C6 alkylene-; -NRm-(C1-C6 alkylene)-; or -NRn-, where Rm and Rn are independently -H or C1-C6. A benzamide derivative compound represented by chemical formula I as described in claim 1 or 2, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.

12. L ４ is a single bond; -(CH ２ )-;-(CH ２ ) ２ -;- (CH ２ ) ３ -;- (CH ２ ) ４ -;- (CH ２ ) ５ -;-NH-;-NHCH ２ -;-NH(CH ２ ) ２ -;-NH(CH ２ ) ３ -;-CH(CH ３ )-;-CH ２ NH-;-(CH ２ ) ２ NH-; or -(CH ２ ) ３ NH-, and the L ４ -H is either not substituted or L ４ At least one of the -H atoms may be independently substituted with a -C1-C6 alkyl group. The benzamide derivative compound represented by chemical formula I as described in claim 11, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

13. R ３ teeth, H; C1-C6 alkyl; 【Transformation 8】 【Chemistry 9】 And, At this time, the R ３ -H is either not substituted or R ３ One or more H atoms are independently -C1-C6 alkyl, -C1-C6 alkoxy, -phenoxy, -OH, -(C1-C6 alkylene)-OH, -COOH, -(C1-C6 alkylene)-COOH, (C1-C6 alkylene)-CN, -NRoRp, (C1-C6 alkylene)-NRqRr, -C(=O)-(C1-C6 alkyl), -C(=O)-(C3-C8 cycloalkyl), -C(=O)-(6- to 14-membered aryl), -NO ２ ,-CHF ２ , -CF ３ , -OCF ３ -C(=O)NRsRt (wherein -C(=O)NRsRt, the -H is either not substituted or one or more -Hs may be independently substituted with halogens), -C(=O)-(C1-C6 alkylene)-NRuRv, -NRwRx, or may be substituted with halogens, and the R ３ If it is a heterocycloalkenyl, then -CH ２ - is either not substituted or has at least one -CH ２ Each of the -s may be independently substituted with -(C=O)-, where Ro, Rp, Rq, Rr, Rs, Rt, Ru, Rv, Rw, or Rx is independently H or C1-C6 alkyl in all cases. The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

14. The aforementioned R ３ -H is either not substituted or R ３ At least one of the -H atoms is independently -C1-C6 alkyl, -C1-C6 alkoxy, -phenoxy, -OH, or -CH ２ F, -CHF ２ , -CF ３ , -OCF ３ , halogen, -(C=O)OCH ２ CH ３ , -(C=O)CH ３ , -(C=O)CH(CH ３ ) ２ , -(C=O)CHCH ３ NH ２ , -NH ２ , - NHCH ３ , -N(CH ３ ) ２ , -COOH, -(C=O)NH ２ , -(C=O)NHCH ３ , -(C=O)N(CH ３ ) ２ , -NO ２ , -(C=O)NHCH ２ CF ３ , -CH(CH ３ )OH, -CH ２ (CH ３ )OH, -CH ２ CN, -CH(CH ３ )CN, -C(CH ３ )CH ２ CN, -(CH ２ ) ２ NH ２ ,-(CH ２ ) NH ２ ,-(CH ２ ) ３ NH ２ ,-(CH ２ ) ４ NH ２ ,-(CH ２ ) ２ OH, - (CH ２ )OH, -(CH ２ ) ３ OH, - (CH ２ ) ４ OH, - (CH ２ ) ２ COOH、-(CH ２ )COOH、-(CH ２ ) ３ COOH、 【Chemistry 10】 It may be replaced with the above R ３ but 【Chemistry 11】 If that is the case, -CH ２ - is not substituted, or at least one -CH ２ - may be substituted with -(C=O)-, The benzamide derivative compound represented by chemical formula I as described in claim 13, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

15. The aforementioned chemical formula I is a compound represented by the following chemical formula I-1, 【Chemistry 12】 In the above chemical formula I-1, R １ , L １ , X, L ３ , R ２ , L ４ , R ３ The compound represented by chemical formula I as defined in claim 1, is a benzamide derivative compound represented by chemical formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.

16. The aforementioned R １ teeth, 【Chemistry 13】 And at this time, R １ -H is either not substituted, or one or more H atoms are independently halogens, -NH ２ , -NO ２ , - NHCH ３ , -N(CH ３ ) ２ , or may be substituted with -OH, The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

17. L １ is methylene (-CH ２ -), ethylene (-CH ２ CH ２ -), n-propylene (-CH ２ CH ２ CH ２ -), isopropylene (-CHCH) ３ CH ２ ), n-butylene (-CH ２ CH ２ CH ２ CH ２ -), sec-butylene (-CHCHCH ３ CH ２ CH ２ -), isobutylene (-CH ２ CHCH ３ CH ２ -), tert-butylene (-CCH ３ CH ３ CH ２ -), n-pentylene (-CH ２ CH ２ CH ２ CH ２ CH ２ -), or n-hexylene (-CH ２ CH ２ CH ２ CH ２ CH ２ CH ２ It may also be methylene (-CH) or, more specifically, methylene (-CH) ２ -), ethylene (-CH ２ CH ２ -), n-propylene (-CH ２ CH ２ CH ２ -), isopropylene (-CHCH) ３ CH ２ ), n-butylene (-CH ２ CH ２ CH ２ CH ２ -), n-pentylene (-CH ２ CH ２ CH ２ CH ２ CH ２ -) or n-hexylene (-CH ２ CH ２ CH ２ CH ２ CH ２ CH ２ -) is The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

18. X is, 【Chemistry 14】 In this case, the -H of X is either not substituted, or one or more -H are independently a C1-C6 alkyl, halogen, -OH, C1-C6 alkoxy, or -CF ３ It may be replaced with, The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

19. The aforementioned X 【Chemistry 15】 In this case, -H is either unsubstituted or one or more -H are independently C1-C6 alkyl, halogen, -C1-C6 alkoxy, -OH, or -CF ３ It may be replaced with, The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

20. L ３ is a single bond, -(CH ２ )-,-(CH ２ ) ２ -, - (CH ２ ) ３ -, - (CH ２ ) ４ -, - (CH ２ ) ５ -, -(C=O)-NH(CH ２ n is -(C=O)NH- or -(C=O)-, in which case n is 0, 1, 2, 3, or 4. The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

21. R ２ H; halogen; C1-C6 alkyl; C1-C6 alkoxy; -NH ２ ; 【Chemistry 16】 And, At this time, the R ２ -H is either not substituted or R ２ One or more of the -H atoms are, independently, halogens, -C1-C6 alkoxys, and -NH ２ Alternatively, it may be substituted with -C1-C6 alkyl. The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

22. L ４ is a single bond; -(CH ２ )-;-(CH ２ ) ２ -;- (CH ２ ) ３ -;- (CH ２ ) ４ -;- (CH ２ ) ５ -;-NH-;-NHCH ２ -;-NH(CH ２ ) ２ -; or -NH(CH ２ ) ３ - and At this time, L ４ -H is either not substituted or L ４ At least one of the -H atoms may be independently substituted with a -C1-C6 alkyl group. The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

23. R ３ H; C1-C6 alkyl; 【Chemistry 17】 And, At this time, the R ３ -H is either not substituted or R ３ At least one of the -H atoms is independently -C1-C6 alkyl, -C1-C6 alkoxy, or -NH ２ , -CF ３ , -OCF ３ , halogen, or [Chemistry 18] It may be replaced with, The benzamide derivative compound represented by chemical formula I as described in claim 15, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

24. The aforementioned chemical formula I is a compound represented by the following chemical formula I-2, 【Chemistry 19】 In the aforementioned chemical formula I-2, R １ , L １ , X, L ３ , R ２ , L ４ , R ３ This is a compound represented by chemical formula I-2, as defined in claim 1. The benzamide derivative compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

25. In the aforementioned chemical formula I-2, The aforementioned R １ teeth, 【Chemistry 20】 And at this time, R １ -H is either unsubstituted or one or more H atoms are independently a halogen (F, Br, Cl, or I), -NH ２ , -NO ２ , - NHCH ３ , -N(CH ３ ) ２ , or may be substituted with -OH, Said L １ It is a C1-C6 alkylene, The aforementioned X is, 【Chemistry 21】 In this case, the -H of X is either not substituted, or one or more -H are independently a C1-C6 alkyl, a halogen (F, Br, Cl or I), an -OH, a -C1-C6 alkoxy, or a -CF ３ It may be replaced by the above X 【Chemistry 22】 If that is the case, -CH ２ - is not substituted, or at least one -CH ２ Each of the hyphens may be independently substituted with -(C=O)-, Said L ３ These are single bonds or C1-C6 alkylenes. The aforementioned R ２ H, halogen, -NH ２ ,or 【Chemistry 23】 And at this time, R ２ -H is either not substituted or R ２ One or more of the -H atoms are, independently, halogens (F, Cl, Br, or I), -C1-C6 alkoxys, and -NH ２ , or may be substituted with -C1-C6 alkyl, L ４ It is a single bond, -C1-C6 alkylene-, The aforementioned R ３ teeth, 【Chemistry 24】 It may be so, in this case, R ３ -H is either not substituted or R ３ At least one of the -H atoms may be independently substituted with a -C1-C6 alkyl, -C1-C6 alkoxy, or halogen. The benzamide derivative compound represented by chemical formula I as described in claim 24, its stereoisomer, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

26. The compounds listed in Table A below, their stereoisomers, their pharmaceutically acceptable salts, or their hydrates or solvates: Table 1 Table 2 Table 3 Table 4 Table 5 Table 6 Table 7 Table 8 Table 9 Table 10 Table 11 Table 12 Table 13 Table 14 Table 15 Table 16 Table 17 Table 18 Table 19 Table 20 Table 21 Table 22 Table 23 Table 24 Table 25 Table 26 Table 27 Table 28 Table 29 Table 30 Table 31 Table 32 Table 33 Table 34 Table 35 Table 36 Table 37 Table 38 Table 39 Table 40 Table 41 Table 42 Table 43 Table 44 Table 45 Table 46 Table 47 Table 48 Table 49 Table 50 Table 51 Table 52 Table 53 Table 54 Table 55 Table 56 Table 57 Table 58 Table 59 Table 60 Table 61 Table 62 Table 63 Table 64

27. A pharmaceutical composition comprising the compound represented by chemical formula I as described in claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof.

28. The pharmaceutical composition according to claim 27, wherein the pharmaceutical composition exhibits NAMPT inhibitory activity.

29. The pharmaceutical composition is the pharmaceutical composition according to claim 28 for preventing or treating cancer.

30. The pharmaceutical composition according to claim 29, wherein the cancer is a solid tumor or a hematological cancer.

31. The pharmaceutical composition according to claim 30, wherein the cancer is one selected from the group consisting of skin cancer, melanoma, lymph node cancer, breast cancer, cervical cancer, uterine cancer, gastrointestinal cancer, lung cancer, ovarian cancer, prostate cancer, colorectal cancer, colon cancer, rectal cancer, oral cancer, brain cancer, head and neck cancer, pharyngeal cancer, testicular cancer, kidney cancer, pancreatic cancer, bone cancer, spleen cancer, liver cancer, bladder cancer, laryngeal cancer, nasal cavity cancer, AIDS-related cancer, esophageal cancer, gastrointestinal cancer, stomach cancer, pancreatic cancer, colorectal cancer, virus-related cancer, nasopharyngeal cancer, vaginal cancer, vulvar cancer, penile cancer, Kaposi's sarcoma, Burkitt lymphoma, T-cell lymphoma, Merkel cell carcinoma, multiple myeloma, acute and chronic leukemia, lymphoblastic leukemia, myeloid leukemia, lymphocytic leukemia, and myeloid leukemia.

32. A method for preventing or treating cancer by administering to a subject the compound represented by chemical formula I according to claim 1, its stereoisomer, pharmaceutically acceptable salts thereof, or their hydrates or solvates, or the pharmaceutical composition according to claim 27.

33. Use of the compound represented by chemical formula I according to claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof, or the pharmaceutical composition according to claim 27, for the prevention or treatment of cancer.

34. Use of the compound represented by chemical formula I according to claim 1, its stereoisomers, pharmaceutically acceptable salts thereof, or hydrates or solvates thereof, or the pharmaceutical composition according to claim 27, for the purpose of preventing or treating cancer and for use in the manufacture of a drug.

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