Multi-component liquid composition preparation kit manufacturing tool

Abstract

To provide a method for producing efficiently, a kit for preparing a multi component liquid composition by pressing, a liquid agent in which, liquid agent package bodies for respectively holding a liquid agent therein, are sealed in an outer bag, and making the liquid agents flow into the outer bag for mixing the liquid agents, by (semi) batch process.SOLUTION: A jig 100 is used for holding an open outer bag 60 whose one end part is open and which is a material member of an outer bag, in an open state of the opening, and two or more liquid agent package bodies 20 are held to prescribed positions in the outer bag, then, by a method of heat seal and the like, the opening of the outer bag is sealed and the two or more liquid agent package bodies are fixed in a bag body storage space of the outer bag.SELECTED DRAWING: Figure 4

Description

[Technical field]

[0001] The present invention relates to a kit for preparing a multi-component liquid composition such as a dental adhesive. of manufacturing When doing so Concerning the fixture used. [Background technology]

[0002] Dental materials such as composite resins and composite resin-type resin cements (hereinafter sometimes abbreviated as "CR, etc."), which are commonly used in dental treatment, have almost no adhesiveness to tooth structure by themselves. For this reason, when performing treatment (tooth restoration), in order to firmly bond the hardened body of CR, etc. to the tooth structure, it is necessary to apply a dental adhesive (also called a bonding material) to the tooth surface using an applicator before filling or pressing with CR, etc.

[0003] A dental adhesive generally comprises a polymerizable monomer including a polymerizable monomer having an acidic group, and a polymerization initiator for polymerizing and curing the polymerizable monomer. As the polymerization initiator, a chemical polymerization initiator that functions without the need for light irradiation or heating may be used. The chemical polymerization initiator includes a combination of multiple components such as a reducing agent and an oxidizing agent that can react immediately upon contact, and therefore must be stored in two or more portions. For this reason, dental adhesives using a chemical polymerization initiator are generally stored as multiple liquid compositions by appropriately dividing the polymerizable monomer component in accordance with the division of the chemical polymerization initiator component, and the divided liquid compositions are mixed at the time of use to prepare the dental adhesive. In addition, kits (in the present invention, a kit means a product in which two or more agents are combined into one product for the purpose of reducing the burden during preparation and preventing contamination and foreign matter from entering) and jigs for facilitating such storage, preparation, and application (using an applicator) are also known.

[0004] For example, Patent Document 1 describes such a kit as a kit for preparing a multi-component liquid composition, which is a kit for storing components of a multi-component liquid composition that exhibits a predetermined function as two or more liquid agents and for mixing the packaged liquid agents at the time of use to prepare the multi-component liquid composition, the kit including a composite liquid package having a plurality of liquid agent storage sections and a connecting section, wherein all of the plurality of liquid agent storage sections are connected to each other at the connecting sections to form an integrated body, and an outer bag that fixes the composite liquid package therein and airtightly houses the composite liquid package, the outer bag having a liquid reservoir space that is capable of holding all of the liquid agent that flows out when a pressing force is applied to the liquid agent held in the liquid agent storage section of the composite liquid package fixed and housed therein, causing the liquid agent to flow out from one end of the liquid agent storage section, without causing the liquid agent to come into contact with the composite liquid package.

[0005] This multi-component liquid composition preparation kit can be used as follows if a weakened line 44 is formed as shown in Fig. 1. That is, first, the front and back walls of the outer bag 3 are pinched with two fingers to press the outer bag 3, causing the liquid agent to flow out of the composite liquid agent package into the liquid storage space, and then the outer bag 3 is broken along the weakened line 44 from the notch 46 to remove the upper part, forming an applicator insertion opening 48. Then, the outer bag 3 is held with one hand and the applicator 50 is held with the other hand, and the applicator 50 is inserted into the outer bag 3 through the applicator insertion opening 48 to deposit the liquid agent stored in the liquid holding portion 54, and then the dental adhesive composition can be applied to the desired site of the patient's tooth to be treated.

[0006] Furthermore, Patent Document 1 describes a method for producing a kit for preparing the above-mentioned multi-component liquid composition, which includes the steps of: "a temporary fixing step of temporarily fixing a strip-shaped substrate made of a heat-sealable laminate film or a heat-sealable laminate sheet, the strip-shaped substrate including at least an inner layer made of a sealant material and an outer layer made of an exterior material, on the upper surface of the strip-shaped substrate at a predetermined interval in the longitudinal direction of the strip-shaped substrate, the other end of the bag body in the liquid agent storage section of the composite liquid agent package being perpendicular to the longitudinal direction of the strip-shaped substrate, and a temporary fixing step of temporarily fixing the strip-shaped substrate at a predetermined interval in the longitudinal direction of the strip-shaped substrate, the composite liquid agent package obtained in the temporary fixing step being parallel to the longitudinal direction of the strip-shaped substrate, the both side end regions of the strip-shaped substrate being temporarily fixed at a predetermined interval in the longitudinal direction of the strip-shaped substrate, the both side end regions of the strip-shaped substrate being temporarily fixed at a predetermined interval in the longitudinal direction of the composite liquid agent package obtained in the temporary fixing step being heat-sealed ... being heat-sealed, the both side end regions of the strip-shaped substrate being temporarily fixed at a predetermined interval in the longitudinal direction of the composite liquid agent package obtained in the temporary fixing step being parallel to each other. and a bag forming step of heat-sealing and joining the adjacent temporarily-fastened composite liquid agent packages of the cylindrical body obtained in the cylindrical forming step in a direction perpendicular to the longitudinal direction to join the portions between the adjacent temporarily-fastened composite liquid agent packages and cutting a central part or an approximately central part of the joined parts in a direction perpendicular to the longitudinal direction to obtain a pillow-shaped flat bag containing one of the composite liquid agent packages, wherein the integrated fusion sealant material at the joint parts of the temporarily-fastened composite liquid agent packages and the sealant material constituting the inner layer of the belt-shaped base material are fused together during the heat sealing in the bag forming step. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] International Publication No. 2020 / 158238 Brochure Summary of the Invention [Problem to be solved by the invention]

[0008] The method described in the cited document 1 is a continuous process in which the outer pouch and the multi-component liquid composition preparation kit are produced simultaneously, allowing for efficient mass production, but since it is not a batch process, it is difficult to respond to small changes in specifications, and efficiency can actually decrease when considering losses (of time, energy, materials, etc.) required for stabilization at the start of the process and the operating rate of the equipment, etc. Therefore, the present invention aims to provide a method for producing a multi-component liquid composition preparation kit by a batch process or semi-batch process. [Means for solving the problem]

[0009] The present invention aims to solve the above problems. ,two The liquid agent package includes the above liquid agent package and an outer bag consisting of a flat bag having one end and the other end and having a rectangular shape with two main surfaces, both of which are substantially the same in shape, and the two or more liquid agent packages each having one end and the other end and containing two or more liquid agents each of which is substantially the same in shape and contains two or more liquid agents, and the liquid agent is configured to flow out from one end by applying a pressing force to the liquid agent contained in each of the bags. The inner space of the outer bag is a liquid agent package containing space located near the other end. a liquid reservoir space located near one end of the outer bag, and the two or more liquid packages are fixed and airtightly contained within the liquid package accommodating space of the outer bag, and when a pressing force is applied to the liquid held inside the two or more bags of the two or more liquid packages by pressing the outer bag, causing the liquid to flow out from one end of the bags, the flowed-out liquid can be held in the liquid reservoir space without coming into contact with the two or more bags, the method comprising the steps of: a member preparing step of preparing a material member for the outer bag, the outer bag being in an open state with the other end portions of the two main surfaces, front and back, of the outer bag not being joined, and the two or more liquid agent packages; The two or more Liquid Packaginga member arranging step for holding the open outer bag and the two or more liquid agent packages in a "set completed holding state" in which the two or more liquid agent packages are arranged and held at predetermined positions in an area that will be a space for accommodating the liquid agent packages within the opening of the open outer bag, the opening of which is held by widening the opening of the other end portion so that a body can be inserted; and a sealing and integration step in which the other parts of the two main surfaces, front and back, that form the opening of the open outer bag held in the set-completed and held state in the member arrangement step are closed and joined to seal the opening, and the two or more liquid agent packages are fixed and airtightly accommodated in a liquid agent package accommodation space of the outer bag; A method for producing a multi-component liquid composition preparation kit, comprising: (hereinafter, also referred to as "the manufacturing method of the present invention") It is.

[0010] To be more specific: each of the two or more bags in the two or more liquid agent packages is made of a heat-sealable laminate film or a heat-sealable laminate sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and has one end and the other end which are sealed portions formed by heat-sealing the ends of the heat-sealable laminate film or the heat-sealable laminate sheet, The multi-component liquid composition preparation kit is a manufacturing object, and the outer bag is a pillow flat bag made of a heat-sealable laminated film or a heat-sealable laminated sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and has one end sealed part, the other end sealed part and the outer bag back sealed part formed by heat sealing at one end, the other end and the back, respectively; the arrangement positions of the two or more liquid agent packages in the set completion and holding state of the member arrangement step are positions where, when the opening of the open outer bag is closed, other end portions of all of the two or more liquid agent packages are sandwiched between other end portions of the open outer bag facing each other, In the sealing and integrating step, the other end of the open outer bag is heat-sealed to simultaneously join and seal the other end and fix the two or more liquid agent packages to the inside of the outer bag. Manufacturing of the Invention (hereinafter, also referred to as "the preferred production method of the present invention") Regarding the fixture used .

[0011] That is, The present invention Shape The attitude is, A "multi-component packaging device" comprising an "outer bag" and "two or more liquid agent packages" each having two substantially identical rectangular shapes on the front and back main surfaces and one end and the other end, the outer bag being made of a heat-sealable laminated film or heat-sealable laminated sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, the outer bag being made of a pillow flat bag having one end seal part, the other end seal part and the outer bag back seal part formed by heat sealing at one end, the other end and the back, respectively, and the two or more liquid agent packages being fixed and airtightly contained in a liquid agent package containing space, which is an internal space located near the other end of the outer bag. a "systematic liquid composition preparation kit" which is a material member of the outer bag, the other end of which is unjoined and open, and which holds the open outer bag and the two or more liquid agent packages in a "set and held state" in which the two or more liquid agent packages are arranged and held at predetermined positions in an area that will be the liquid agent package storage space of an "open outer bag," and then heat-seals the other end of the open outer bag to simultaneously join and seal the other end and fix the two or more liquid agent packages inside the outer bag, the jig being used to hold the open outer bag and the two or more liquid agent packages in the set and held state, The jig body is made of a block body having a bottom surface made of a flat surface and a top surface made of a flat surface arranged parallel to the bottom surface, and a bottomed groove having an opening on the top surface is formed therein. The bottomed groove is formed so that the open outer bag can be inserted in and out freely, and is a structure for holding the open outer bag and the two or more liquid agent packages in the set-completed holding state when one end edge of the open outer bag is inserted into the bottomed groove so as to abut against the groove bottom. and a "narrow width portion" formed so as to communicate with the wide width portion in both length directions and downward of the wide width portion, A direction along the edge of one end of the outer bag is defined as a length direction, a direction perpendicular to the length direction and from the edge of the one end toward the other end is defined as a height direction, and a direction perpendicular to the length direction and the height direction is defined as a thickness direction, The length (mm) of one end edge of the open outer bag is L 1 The length (mm) of one end edge of each bag of the two or more liquid drug packages is L 2 year, The height (mm) from the bottom of the groove and the edge of one end of the open outer bag is H 1 The height (mm) of the edge of one end of the region that will become the other end seal portion when the outer bag is made is H 2 The height (mm) of the lowest edge of one end of the bag in the two or more liquid drug packages is H 3 year, The thinnest thickness (mm) among the thicknesses (mm) W of the two or more liquid drug packages is W min The sum of all thicknesses (mm) is W all year, The minimum width, maximum width, depth and length of the wide portion are respectively defined as minimum width: w 11 , maximum width w 12 , depth d 1 and length l 1 The minimum width, maximum width, depth and length of the narrow portion are respectively set as minimum width: w 21 , maximum width w 22 , depth d 2 and length l 2 When The wide portion and the narrow portion are each selected from the following (1) to (7). (1) (Thickness of one end of the outer bag) <w 11 =(or ≒)w 22<W min (2) (Thickness of one end of the outer bag at the opening) <w 21 (3) W all <w 12 (4) (H 2 -H 3 )×0.1≦d 1 <(H 2 -H 3 ) (5) d 1 <d 2 (6) (d 2 -d 1 )=(or ≒)H 3 (7) L 2 <l 2 <L 1 <l 1 Satisfy all the relationships shown in The present invention relates to a tool for manufacturing a multi-component liquid composition preparation kit.

[0013] In the manufacturing jig for a multi-component liquid composition preparation kit having the above-described configuration (hereinafter also referred to as the "jig of the present invention"), in the "set completion and holding state" of the member arrangement step in the preferred manufacturing method of the present invention, the two or more liquid agent packages are held in a position where, when the opening of the open outer bag is closed, the other end portions of all of the two or more liquid agent packages are sandwiched between the other end portions facing each other of the open outer bag, and in the set completion and holding state, the outer bag rear seal portion near the other end of the open outer bag is provided with a bottomed groove in the narrow width portion and / or the wide width portion. InIt is preferable that a rear seal relief notch is provided to prevent the maximum opening width of the open outer bag from being narrowed by contact with the inner surface of the upper region.

[0014] Furthermore, in these preferred embodiments of the jig of the present invention, it is more preferable that it has at least one of the following characteristics (1) to (3).

[0015] (1) The jig body has a basic shape consisting of a rectangular prism with rectangular top and bottom surfaces, and multiple bottomed grooves are arranged in a row at predetermined intervals along the longitudinal direction of the top surface.

[0016] (2) The above They are arranged in a row at regular intervals along the longitudinal direction of the top surface of the jig body. Each of the plurality of bottomed grooves is Each bottomed groove The length direction of above They are arranged in a row at a constant angle of 1 to 3 degrees relative to the longitudinal direction of the surface.

[0017] (3) At least one of the longitudinal side surfaces of the jig body is They are arranged in a row at regular intervals along the longitudinal direction of the top surface of the jig body. Laser marking openings having a predetermined opening area are provided in correspondence with the plurality of bottomed grooves and communicate with the respective narrow width portions. Effect of the Invention

[0018] According to the manufacturing method of the present invention, it is possible to efficiently manufacture a bonding material preparation kit in a batch or semi-batch process using a pre-prepared open outer bag or a bag for holding a liquid agent in portions as raw materials. Furthermore, by using the jig of the present invention, it is possible to carry out the method of the present invention more efficiently and reliably. [Brief description of the drawings]

[0019] [Figure 1]This figure is a schematic diagram showing the kit disclosed in Patent Document 1, which is also the present kit, and how to use the kit, and corresponds to Figures 6 and 10 of Patent Document 1. [Diagram 2] The figure shows (A) an oblique view and (B) a XX' cross-sectional view of a multi-component liquid composition preparation kit (the present kit) suitable as the target product of the production method of the present invention. [Diagram 3] The figures show (A) a front view, (B) a plan view, and (C) a right side view of a representative jig of the present invention. [Figure 4] This figure shows (a) a YY' cross-sectional view in a state before an open outer bag is inserted into the jig of the present invention shown in Figure 3, and (b) a YY' cross-sectional view when two or more liquid agent packages have been arranged in a set and held state after the open outer bag has been inserted. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0020] Hereinafter, with reference to the drawings, a detailed description will be given of a multi-component liquid composition preparation kit (hereinafter also referred to as "the kit") for which the auxiliary device of the present invention is used, the manufacturing method of the present invention, and the jig of the present invention.

[0021] In this specification, unless otherwise specified, the expression "x to y" using the numerical values ​​x and y means "greater than or equal to x and less than or equal to y." In such an expression, when a unit is added only to the numerical value y, the unit is also applied to the numerical value x. In addition, in this specification, the term "(meth)acrylate" means both "acrylate" and "methacrylate," and the term "(meth)acryloyl" means both "acryloyl" and "methacryloyl."

[0022] 1. This kit The multi-component liquid composition preparation kit (the present kit), which is the production target of the present invention, is not particularly different from the kit shown in Figure 1 and disclosed in Patent Document 1. Hereinafter, the present kit 10 will be described with reference to Figures 1 and 2.

[0023] As shown in FIG. 2, the kit 10 includes two or more liquid agent packages 20; and an outer bag 30; which is a flat bag 33 having one end 31 and the other end 32 and has a substantially identical rectangular shape with two main surfaces 34a, b on the front and back. The two or more liquid agent packages 20 are two or more bags 20 (in the figure, they are shown as packaging materials for the liquid agent packages, so they are represented by the same numbers here) having substantially the same shape, each having one end 21 and the other end 22, and a liquid agent 23 is enclosed and held therein. The liquid agent 23 is enclosed in such a manner that a pressing force is applied to the liquid agent 23 held inside each bag, causing the liquid agent 23 to flow out from the one end 21. The outer bag 30 has a liquid agent package storage space (bag storage space) 36 and a liquid pool space 37 inside, and the two or more bags 20 are fixed and hermetically stored in the bag storage space 36.

[0024] Regarding the liquid agent 23 packaged in the two or more liquid agent packages (bags) 20, each liquid agent 23 held inside each bag is a component of a multi-component liquid composition that exhibits a predetermined function, divided into two or more (specifically, the number of bags), and the multi-component liquid composition can be prepared by flowing all of the liquid agents 23 held in the two or more bags into the liquid pooling space 37 and mixing them. The liquid pooling space 37 is a space that can hold the (all) liquid agents 23 that have flowed out without coming into contact with the two or more bags 20 when a pressing force is applied to the liquid agents 23 held inside the two or more bags 20 contained in the bag storage space 36 by pressing the outer bag 30 to cause the liquid agents 23 to flow out of (all) the bags 20. The (all) liquid agents 23 that have flowed out are stored in the liquid pooling space 37, so that it is possible to prepare the multi-component liquid composition and perform the application operation described below without being hindered by the bags 20.

[0025] In the present kit 10 shown in FIG. 2, the two main surfaces 34 of the outer bag 30, that is, the one main surface 34a and the other main surface 34b facing each other, are defined with pressurized areas 35a, b at predetermined positions corresponding to each other. The pressurized areas 35(a, b) are areas determined based on the shape, size and amount of the liquid medicine 23 held therein of the two or more bags 20 (flat bags 24), and the position of the bag body storage space 36 (or the fixed position of the two or more bags 20), and are defined as areas where the liquid medicine 23 can be reliably and efficiently flowed out of one end (one end) 21 of the bag body 20 by pressing the areas on the outer bag 30. Therefore, the pressurized areas 35a, b are defined at substantially the same positions on the main surfaces 34 of the outer bag 30 (i.e., the one main surface 34a and the other main surface side 34b). The area printed with "Push here" in FIG. 2(A) corresponds to the pressurized area 35.

[0026] In the present kit 10 shown in FIG. 2, each of the bags 20 of the two or more liquid agent packages is a flat bag 24 having substantially the same rectangular shape, and the two or more bags 20 (flat bags 24) are arranged so that the liquid agent 23 flows out from one end 21 of all of the bags 20 (flat bags 24) by pressing the pressed areas 35a, b of the outer bag 30, with the one end 21 and the other end 22 facing the one end 31 side and the other end 32 side of the outer bag 30, respectively, and the other end 22 of all the bags 20 (flat bags 24) are stacked and sandwiched between the other end 32a on the one main surface 34a side and the other end 32b on the other main surface side 34b, and fixed and airtightly contained within the bag storage space 36.

[0027] The size of the bag 20 and the outer bag 30 may be appropriately determined according to the amount of the liquid agent 23 to be held, but when the multi-component liquid composition is a dental adhesive, the amount of the liquid agent 23 held in each bag 20 is usually about 0.03 to 0.1 ml since it is disposable, and the size of the bag 20 (flat bag 24) is about 16 to 40 mm in length and about 5 to 15 mm in width. The size of the outer bag 30 is about 28 to 72 mm in length and about 12 to 36 mm in width, and the area of ​​the pressed region 35 is 240 to 400 mm. 2 That's about it.

[0028] The width L of the flat bag 33 constituting the outer bag 30 1 is the width L of the bag body 20 (flat bag 24) 2 and by fixing the two or more bags 20 toward one side end 31 toward the inside of the outer bag, an applicator insertion space 38 adjacent to the bag body accommodating space 36 is provided on the other end side of the liquid collecting space 37 of the outer bag 30. A weakened line: WL is formed on one main surface 34a and the other main surface 34b of the outer bag 30 for cutting out and removing a removal portion 39 consisting of a part of the other end side of the area covering the applicator insertion space 38 to form an applicator insertion opening (not shown).

[0029] The relationship between the present kit 10 shown in Fig. 2 and the kit shown in Fig. 1 (disclosed in Patent Document 1) will be described. In Fig. 2, the fixing positions of two or more liquid agent packages (bags) 20 are such that the position of the bag accommodation space 36 is approximately at the center of the outer bag 30, and when viewed from the other main surface 34b side, this corresponds to the multi-component liquid composition preparing kit 1 shown in Fig. 1. That is, each package, one end, the other end, and the liquid agent in the composite liquid agent package 2 in Fig. 1 respectively correspond to the bag 20 (flat bag 24), one end, the other end, and the liquid agent 23 in the present kit 10, and the composite liquid agent package 2 corresponds to the other end portions 22 of all the bags 20 in the present kit 10 stacked and integrated together. In addition, the outer bag 3, lower end seal portion (one end) 40, upper end seal portion (the other end) 42, and weakened line 44 in Figure 1 correspond to the outer bag 30 (flat bag 33), one end 31, the other end 32, and weakened line WL in the kit 10 in Figure 2, respectively.

[0030] A typical example of the multi-component liquid composition is a so-called two-liquid mixed dental adhesive containing a polymerizable monomer including an acidic group-containing polymerizable monomer and a polymerizable monomer not having an acidic group, a chemical polymerization initiator, and a water-soluble organic solvent and / or water as main components. Here, the following components can be preferably used as each component of the two-liquid mixed dental adhesive.

[0031] That is, examples of the acidic group-containing polymerizable monomer include 2-(meth)acryloyloxyethyl dihydrogen phosphate, 10-(meth)acryloyloxydecyl dihydrogen phosphate, di[2-(meth)acryloyloxyethyl]hydrogen phosphate, di[10-(meth)acryloyloxydecyl]hydrogen phosphate, 4-(meth)acryloxyethyl trimellitic acid, 11-(meth)acryloyloxy-1,1-undecanedicarboxylic acid, 1,4-di(meth)acryloyloxypi Compounds having at least one acidic group, such as a phosphoric acid group, a carboxy group, a sulfonic acid group or a phosphonic acid group, and at least one polymerizable unsaturated group in one molecule, such as romellitic acid, 2-(meth)acryloyloxyethyl maleic acid, 2-(meth)acryloyloxyethyl phthalic acid, 2-(meth)acryloyloxyethylhexahydrophthalic acid, 2-methacrylamide-2-methylpropanesulfonic acid, 2-acrylamide-2-methylpropanesulfonic acid, p-vinylbenzenesulfonic acid, and vinylsulfonic acid, can be suitably used.

[0032] Examples of polymerizable monomers having no acidic group include 2-hydroxyethyl (meth)acrylate, 2-hydroxypropyl (meth)acrylate, glycerol di(meth)acrylate, 2,2'-bis{4-[3-(meth)acryloyloxy-2-hydroxypropoxy]phenyl}propane, 2,2'-bis[4-(meth)acryloyloxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxypolyethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxydiethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxytetraethoxyphenyl]propane, 2,2'- Bis[4-(meth)acryloyloxypentaethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxydipropoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxyethoxyethoxyphenyl]propane, 2-[4-(meth)acryloyloxydiethoxyphenyl]-2-[4-(meth)acryloyloxytriethoxyphenyl]propane, 2-[4-(meth)acryloyloxydipropoxyphenyl]-2-[4-(meth)acryloyloxytriethoxyphenyl]propane, 2,2-bis[4-(meth)acryloyloxypropoxyphenyl]propane, and the like can be suitably used.

[0033] As the water-soluble organic solvent, acetone, methanol, ethanol, n-propanol, isopropyl alcohol, methyl ethyl ketone, etc. can be suitably used.

[0034] As the chemical polymerization initiator, an appropriate combination of an oxidizing agent, a reducing agent, and a polymerization accelerator can be suitably used. As the oxidizing agent, organic peroxides such as benzoyl peroxide, parachlorobenzoyl peroxide, 2,4-dichlorobenzoyl peroxide, acetyl peroxide, lauroyl peroxide, tertiary butyl peroxide, cumene hydroperoxide, 2,5-dimethylhexane, 2,5-dihydroperoxide, methyl ethyl ketone peroxide, and tertiary butyl peroxybenzoate, and azo compounds such as azobisisobutyronitrile, methyl azobisisobutyrate, and azobiscyanovaleric acid can be suitably used. In addition, as the reducing agent, amine compounds such as N,N'-dimethyl-p-toluidine, N,N'-dimethylaniline, N'-β-hydroxyethyl-aniline, N,N'-di(β-hydroxyethyl)-aniline, N,N'-di(β-hydroxyethyl)-p-toluidine, N-methyl-aniline, and N-methyl-p-toluidine can be preferably used. Furthermore, as the polymerization accelerator, vanadium compounds, copper compounds, sulfinates, borate compounds, thiourea compounds, and the like can be preferably used. Note that any chemical polymerization initiator system is designed to function as an initiator when all components are present, and the combination of each component when packaging is appropriately determined in consideration of storage stability according to the type of liquid agent and the specific compound used. For example, borate, which is classified as a polymerization accelerator in the above, also functions as a reducing agent under certain conditions, but it can also be stored in the presence of an oxidizing agent in the absence of an acidic compound (unless it is under acidic conditions).

[0035] From the viewpoint of the manufacturing efficiency of the kit 10, it is preferable that the two or more bags 20 are previously stacked and integrated at the other end 22 of all the bags 20 (flat bags 24) to form a composite liquid agent package. The above-mentioned composite liquid agent package can be suitably produced by a method including: (I) a step of preparing a plurality of individual packages for a liquid agent-containing portion, the individual packages being configured to hold a liquid agent airtight and liquidtight inside a bag body formed of a flat pillow bag having a lower end heat-sealed portion as one end (one end) and an upper end heat-sealed portion as the other end (other end) by vertical pillow packaging using a heat-sealable laminate film or heat-sealable laminate sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material; and (II) a joining step of overlapping all of the other ends (other ends) of the plurality of individual packages for a liquid agent-containing portion prepared in the step of preparing the individual packages for a liquid agent-containing portion, and heating and pressurizing the overlapping region where all of the other ends are overlapped, thereby extruding a part of the sealant material constituting the inner layer in the overlapping region of each of the other ends outward from an end of the outer layer of each of the other ends, while fusing the extruded extended sealant materials to each other.

[0036] The inner layer of the heat-sealable laminated film (or heat-sealable laminated sheet) is composed of a mixture of a resin having high heat fusion (heat-sealing property) as a sealant material, for example, a polymer alloy mainly composed of an ionomer of a copolymer of ethylene and methacrylic acid acrylate, and polyethylene, and the inner layer (sealant material layer) usually has a thickness of 10 to 100 μm, preferably 30 to 80 μm. The outer layer 12 is composed of a resin having low heat fusion (not having heat-sealing property), an inorganic material, or a composite of both, and depending on the liquid agent contained inside, a material that imparts functions such as oxygen gas shielding (oxygen gas impermeability) and ultraviolet ray shielding, a material that enhances transparency so that the presence of the contents can be confirmed, and a material that enhances printability on the outer surface are appropriately selected for the purpose of enhancing the storage stability, etc. In addition, an intermediate layer can be provided between the inner layer and the outer layer to further enhance functionality.

[0037] The outer bag 30 is also a pillow flat bag made of a heat-sealable laminate film (or a heat-sealable laminate sheet) including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and is made into a bag body by heat-welding (heat sealing) both side edges of a rectangular heat-sealable laminate film (or a heat-sealable laminate sheet) to each other to form a back seal part to form a cylindrical shape, and heat-welding (heat sealing) one end (one end edge) and the other end (the other end edge) to each other. The heat-sealable laminate film (or heat-sealable laminate sheet) basically has the same structure as the heat-sealable laminate film constituting the bag body 20, and the same heat-sealing material is used as the heat-sealing laminate film. However, since it is preferable that the outer bag 30 is transparent overall in order to make it easier to check the position of the liquid agent that has flowed out due to pressure, it is preferable to use, as the exterior material constituting the outer layer, a film or sheet of an olefin polymer such as polyethylene, polypropylene, polybutylene, and a copolymer obtained by copolymerizing at least two or more types of olefin monomers selected from ethylene, propylene, butene, etc.

[0038] In the present kit 10, the outer bag 30 is sealed on all four sides to be in a hermetically sealed state. At this time, air (atmosphere) is usually enclosed in the space between the outer bag 30 and the two or more bags 20. In order to apply a pressing force to the liquid agent held in the two or more bags 20 (flat bags 24) to facilitate the liquid agent flowing out of one end (one end) of each liquid agent storage section, it is preferable to adjust the amount of air enclosed in the space so that the volume of the space is 1 to 70%, particularly 5 to 40%, of the maximum volume of the space (the volume obtained by subtracting the volume occupied by the two or more bags 20 contained therein from the volume when the outer bag 30 is filled with as much air as possible under atmospheric pressure or under a slight pressure that does not damage the outer bag 30).

[0039] In addition, the outer bag 30 consisting of a pillow flat bag may be made by heat-welding (heat sealing) both side edges of the above-mentioned rectangular heat-sealable laminate film (or heat-sealable laminate sheet) to each other to form a back seal portion to form a cylindrical shape, heat-sealing the cylindrical body in a direction perpendicular to the length direction at predetermined intervals to form one end (lower end) seal portion, cutting one end along a direction perpendicular to the length direction to form an open outer bag 60 with the other end (upper end) open, and then heat-sealing the other end (upper end) of the open outer bag 60 to form the other end (upper end) seal portion to form the outer bag 30.

[0040] When the kit 10 of the present invention is used, first, the outer bag 30 is pressed to apply a pressing force to all of the liquid agents 23 respectively filled in the two or more bags 20, and the liquid agents 23 are caused to flow out and mixed in the liquid collection space 37 to prepare the dental adhesive, which is the desired liquid composition. Next, the outer bag 30 is broken from the notch along the weakened line WL, and the removed portion 39 above the weakened line WL of the film or sheet covering the applicator insertion space 38 is removed to open the applicator insertion opening (this operation is also called the "applicator insertion opening forming operation"). From there, as shown in the right diagram of Fig. 1, an applicator 50 having a long and thin rod-shaped body 52 and a liquid holding portion 54 disposed at its tip is inserted, and the liquid holding portion 54 is immersed in the dental adhesive and then pulled out to apply the dental adhesive to the desired site of the patient's tooth to be treated, thus performing the application operation.

[0041] 2. The manufacturing method of the present invention The manufacturing method of the present invention is a method for manufacturing the present kit, and is characterized by comprising the following member preparation step, member arrangement step, and sealing and fixing step.

[0042] Component preparation process: A process for preparing a material component for the outer bag, which is an open outer bag in which the other end portions of the two main surfaces, front and back, of the outer bag are unjoined and open, and the two or more liquid agent packages.

[0043] Component placement process: a process of holding the open outer bag and the two or more liquid agent packages in a "set complete holding state" in which the two or more liquid agent packages are placed and held at predetermined positions in an area that will become the liquid agent package storage space within the opening of the open outer bag, which is held by widening the opening of the other end so that the two or more bag bodies can be inserted.

[0044] Sealing and integration process: a process for sealing by closing and joining the other parts of the two main surfaces, front and back, that form the opening of the open outer bag held in the set and held state in the member arrangement process, and fixing the two or more liquid agent packages within the liquid agent package storage space of the outer bag to store them airtight.

[0045] In order to hold the open outer bag and the two or more liquid agent packages in the "set completed and held state" in the member arrangement step, it is preferable to use a dedicated jig.

[0046] In the manufacturing method of the present invention, it is preferable that each of the two or more bags in the two or more liquid agent packages is made of a heat-sealable laminate film or a heat-sealable laminate sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, one end of the heat-sealable laminate film or the heat-sealable laminate sheet is heat-sealed to form one end, and the other end is open. As the two or more liquid agent packages (bags) using such bags, those manufactured by the manufacturing method already explained are preferably used.

[0047] Moreover, the open outer bag is a material member serving as an intermediate material for "a pillow flat bag made of a heat-sealable laminated film or heat-sealable laminated sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and having one end seal part, the other end seal part, and the outer bag back seal part formed by heat sealing at one end, the other end, and the back, respectively", and it is preferable to use the pillow flat bag in a state in which the one end seal part and the back seal part are formed and the other end is open before the other end is heat-sealed. As such an open outer bag, it is preferable to use one obtained when manufacturing the outer bag 30 made of the pillow flat bag described above, which has a back seal part and one end seal part and is in a state in which the other end (upper end) is open, and which is later heat-sealed to form the other end seal part to form the outer bag 30.

[0048] Furthermore, in addition to using two or more liquid agent packages (bags) and an open outer bag constituted by such a heat-sealable laminate film or heat-sealable laminate sheet, it is preferable that the arrangement positions of the two or more liquid agent packages in the set-completed and held state in the member arrangement step are such that, when the opening of the open outer bag is closed, all of the other ends of the two or more liquid agent packages are sandwiched between the opposing other ends of the open outer bag, and that in the sealing and integration step, the other ends of the open outer bag are heat-sealed to simultaneously join and seal the other ends and fix the two or more liquid agent packages to the inside of the outer bag.

[0049] In such a preferred method (preferable manufacturing method of the present invention), the holding of the open outer bag and the two or more liquid agent packages in the "set completion holding state" in the member arrangement step can be preferably performed by using the jig of the present invention. Therefore, the jig of the present invention and the preferred manufacturing method of the present invention using the same will be described in detail below with reference to the drawings.

[0050] 3. The jig of the present invention The jig of the present invention has a jig body consisting of a block body having a bottom surface made of a flat surface and an upper surface made of a flat surface arranged parallel to the bottom surface, and in which a bottomed groove having an opening is formed on the upper surface, and the bottomed groove is formed so that the open outer bag can be inserted and removed freely, and is characterized in that when the edge of one end of the open outer bag is inserted into the bottomed groove so as to abut against the groove bottom, the jig has a structure that can hold the open outer bag and the two or more liquid agent packages in the set complete holding state.

[0051] The block body may be suitably made of a resin material such as polyethylene (PE), polypropylene (PP), polyoxymethylene (POM), polybutadiene terephthalate (PBT), acrylonitrile-butadiene-styrene copolymer synthetic resin (ABS resin), polyamide (PA), polymethyl methacrylate (PMMA), polytetrafluoroethylene (PTFE), etc. The bottomed groove may be formed by cutting, or may be formed by previously dividing the block body into several parts (divided so as to make it easier to assemble the final form) and assembling them.

[0052] The jig of the present invention is not particularly limited as long as it has a structure that can hold the open outer bag and two or more liquid agent packages in a set and held state with the open outer bag inserted into the bottomed groove of the block body, but from the standpoint of being able to reliably and efficiently hold the open outer bag and two or more liquid agent packages in a set and held state, it is preferable that (1) the bottomed groove has a wide portion and a narrow portion, and (2) the direction, length, height (depth) and thickness (width) of the bottomed groove, which are defined in relationship to the shape and size of the open outer bag and two or more liquid agent packages to be used, satisfy the following conditions.

[0053] That is, first, the directions, lengths, etc. that are the premise (criteria) of the conditions to be satisfied will be explained. The directions, lengths, etc. when the open outer bag and the two or more liquid agent packages are held in the set-completed holding state are defined as follows (see Figures 3 and 4).

[0054] [direction] Length direction: A direction along one end edge of the opening outer bag; Height direction: A direction perpendicular to the length direction and from one end edge toward the other end Thickness direction: The direction perpendicular to the length and height directions.

[0055] [Lengths of the outer bag with opening and each bag of two or more liquid drug packages, etc.] The lengths, etc. shall be expressed using the following symbols. L 1 : Length of one end edge of the outer bag (mm) L 2 : Length of one end edge of each bag of two or more liquid drug packages (mm) H 1 : Height of the other end edge of the outer bag from the one end edge (mm) H 2 : Height from the edge of one end of the position that will become the edge of one end of the area that will become the other end seal part when made into an outer bag (mm) H 3 : Height (mm) of the lowest edge of one end of the bag from the edge of one end of the opening of the outer bag in two or more liquid drug packages ·W min : The thinnest thickness (mm) among the thicknesses W of two or more liquid drug packages ·W all : The total thickness of two or more liquid packaging bodies (mm).

[0056] [Lengths of the wide and narrow parts, etc.] The narrow parts refer to the narrow portions of the wide parts in both longitudinal directions and downward, and are formed so as to be continuous with the wide parts, and the lengths, etc. are expressed using the following symbols. The depth refers to the depth from the top surface. l 1 :Length of the wide part (mm) l 2 : Length of narrow part (mm) d 1 : Depth of wide section (mm) d 2 : Depth of narrow part (mm) ·w 11 :Minimum width of wide part (mm) w 21 :Minimum width of narrow part (mm) ·w 12 : Maximum width of the wide part (mm) w 22 : Maximum width of narrow part (mm).

[0057] Next, the conditions that the jig of the preferred embodiment should satisfy will be explained. The jig satisfies all of the relationships shown in (1) to (7) below.

[0058] (1) (Thickness of one end of the outer bag) <w 11 =(or ≒)w 22 <W min (2) (Thickness of one end of the outer bag at the opening) <w 21 (3) W all <w 12 (4) (H 2 -H 3 )×0.1≦d 1 <(H 2 -H 3 ) (5) d 1 <d 2 (6) (d 2 -d 1 )=(or ≒)H 3 (7) L 2 <l 2 <L 1 <l 1 .

[0059] The above-mentioned preferred embodiment of the jig of the present invention will be described below with reference to Figures 3 and 4. The open outer bag 60 (which is the material for the outer bag) shown in Figure 4 has a back seal part and one end seal part, and the other end (upper end) is open, which is manufactured by the method described above, and the other end (upper end) is later heat-sealed to form the other end seal part to form the outer bag 30. Therefore, the parts of the open outer bag 60 in Figure 4 are given the same numbers as the corresponding parts in the outer bag 30.

[0060] The jig 100 of the present invention shown in FIG. 3 is an example of a preferred form of the jig of the present invention, which is capable of holding multiple sets (four sets in the figure) of open outer bags 60 and two or more liquid agent packages 20 in a set-and-hold state at one time, and simultaneously carrying out the heat sealing in the sealing and integration process while they are held in this state, thereby enabling the production of several sets (four in the figure) of kits for preparing a multi-component liquid composition.

[0061] That is, the jig body 110 of the jig 100 is a block body having a basic shape of a rectangular prism, with a bottom surface 111 consisting of a flat surface and a top surface 112 consisting of a flat surface arranged parallel to the bottom surface, and multiple bottomed grooves 120 (four in the figure) are arranged in a row at predetermined intervals along the longitudinal direction of the top surface.

[0062] 3(C) and 4, the bottomed groove 120 is formed to have a width L of the flat bag 33 constituting the open outer bag 60. 1 Slightly longer length 1 having a width w 21 =w 22 (w 22 , w 21 (which may be slightly larger than 2 The groove is a slit-shaped groove having an upper opening 113 at a depth d 1 The wide portion 121 is formed by partially expanding the diameter over the entire width of the wide portion 121. That is, the opening shape of the wide portion 121 is (almost) elliptical, and the YY' cross section at the center is funnel-shaped. On the other hand, the portion outside the wide portion 121 (outside both ends of the wide portion 121 in the length direction) remains a slit-shaped groove, and the portion below the wide portion 121 (depth d 1 The depth (height) of the deeper part is (d 2 -d 1 ) and width is w 21 The narrow portion 122 is formed integrally with the narrow portion 121. Therefore, the cross section of the outer portion at both ends of the wide portion 121 in the longitudinal direction has a depth (height) of d 2 And the width is w 21 In this way, the width of the wide portion (5) is d 1<Depth of narrow part: d 2 It is something that satisfies the above.

[0063] The above condition (1) "(thickness of one end of the outer bag) <w 11 ", the above condition (2) and the above condition (7) "L 1 <l 1 By satisfying the condition (3) above and the condition (1) above of "w", the open-ended outer bag 60 can be inserted into the bottomed groove 120 so as to be freely inserted and removed (removable) with one end 31 of the outer bag facing downward, and when the open-ended outer bag 60 is inserted, the open-ended outer bag 60 can be held upright even with the other end of the open-ended outer bag 60 open to a predetermined width. 11 =(or ≒)w 22 <W min " and the above condition (7) "L 2 <l 2 By satisfying the condition "minimum width of the wide portion: w 11 <Total thickness of two or more liquid drug packages: W min By satisfying the relationship of "(H" and "(H)", two or more liquid agent packages cannot enter narrow width portion 122, and the position of one end of each package is determined, and by satisfying condition (6) above, each package is positioned in a set-completed, held state position as shown in FIG. 4(b). Finally, by satisfying condition (4) above, each package can be held (naturally, independently) in the positioned position. Condition (4) satisfies the relationship of "(H)" and "(H)", because this allows the heat sealing in the sealing and integration step to be performed stably while the package is set in the jig. 2 -H 3 )×0.2≦d 1 <(H 2 -H 3 It is preferable that the value satisfies "(H 2 -H 3 )×0.25≦d 1 <(H 2 -H 3It is more preferable to satisfy "(x)×0.4".

[0064] In the jig 100 of the present invention shown in Fig. 3, the rear seal relief notch 123 is provided in the wide portion 121, so that in the set and held state, it is possible to prevent the outer bag rear seal portion near the other end of the open-ended outer bag 60 from abutting against the inner surface of the bottomed groove upper region, thereby narrowing the maximum opening width of the open-ended outer bag. Also, when the outer bag rear seal portion is accommodated in the rear seal relief notch 123, it is possible to prevent the rear seal from interfering (getting in the way) when the heat sealing is performed while the jig is set.

[0065] In addition, in the jig 100, the multiple (four) bottomed grooves 120 are arranged in a row such that their length direction is inclined at a certain angle of 1 to 3 degrees with respect to the longitudinal direction of the main body upper surface 112. This makes it easier to control the escape of air (inside the open outer bag) when the sealed part is sandwiched when heat sealing is performed using a heat sealing device of the type that sandwiches the sealed part and heat-pressure-bonds (welds) it, such as a heat sealer. For example, when the other end seal part-plan area of ​​the open outer bag 60 is sandwiched on a flat surface, the film surface of the wide width part 121 comes into contact first, and is pressed while escaping air to the left and right from that point, and heat welding is performed. On the other hand, when there is an angle, the film surface of one end of the narrow width part 122 comes into contact first, and is pressed while escaping air in one direction from that point, and heat welding is performed. This makes it possible to prevent wrinkles from forming on the heat-sealed surface and achieve a smooth finish.

[0066] Furthermore, the jig 100 is provided with a laser marking opening 130 having a predetermined opening area, which corresponds to the plurality of bottomed grooves and communicates with each of the narrow width portions, on one of the longitudinal side surfaces of the jig body 110. Through the laser marking opening 130, a lot number (Lot No.), expiration date, etc. can be printed on the surface of the open outer bag 60 (outer bag 30) while it is held by the jig. Unlike a self-supporting container form such as an eye drop bottle, the multi-component liquid composition preparation kit is in the form of a bag made of a film material, so it is extremely difficult to make it stand on its own. In addition, since the main surfaces 34a and 34b after heat sealing are curved, when printing is performed, it is necessary to fix each of them individually in a specific direction. However, by using the jig 100, it becomes possible to print reliably and easily at a predetermined position.

[0067] The jig of the present invention has been described above with reference to Figures 3 and 4, but these are shown as examples, and the technical scope of the present invention is not limited to this specific embodiment. For example, the jig may be divided into two parts along the center line of the narrow width portion 122 along the longitudinal direction of the jig, and the opening outer bag 60 may be set, and then the two parts may be combined. In this way, interference between the film and the jig when inserting the opening outer bag 60 is reduced, and workability can be further improved.

[0068] 4. Preferred manufacturing method of the present invention using the jig of the present invention In the preferred manufacturing method of the present invention using the tool of the present invention, the open outer bag 60 prepared by the method already described and the two or more liquid agent packages 20 are held in a set-up state using the tool of the present invention as described above, and the sealing and integration process is performed in that state. At this time, as shown in Fig. 4(b), when the opening of the open outer bag 60 is closed, the other ends 22 of all of the two or more liquid agent packages 20 are held in a position where they are sandwiched between the other ends 42 facing each other of the open outer bag 60, so that by heat-sealing the other ends 42 of the open outer bag 60, the joining and sealing of the other ends 42 and the fixing of the two or more liquid agent packages 20 to the inside of the outer bag can be performed simultaneously. As described above, the heat sealing can be preferably performed using a heat sealing device of the type that sandwiches the sealed body part and heat-pressure bonds (welds) it, such as a heat sealer. After heat sealing, the lot number, expiration date, etc. can be laser printed through the laser printing opening 130, and then the kit can be removed from the jig to obtain a multi-component liquid composition preparation kit with the markings printed in the designated positions. [Explanation of symbols]

[0069] 1: Multi-component liquid composition preparation kit 2: Composite liquid packaging 3: Outer bag 10: This kit (multi-component liquid composition preparation kit) 20: Liquid packaging body (bag body) 21: One end of the bag body 21a: Edge of one end of the bag 22: The other end of the bag 23: Liquid 24: Flat bag 30: Outer bag 31: One end of the outer bag 32: The other end of the outer bag 33: Flat bag 34: Main surface 34a: One main surface 34b: Other main surface 35(a, b): Pressed area 36: Liquid drug packaging storage space (bag storage space) 37: Liquid storage space 38: Space for inserting applicator 39:Removal section 40: One end (lower end) seal part (one end or one end) 40a: One end edge 42: other end (upper end) seal portion (other end or other end) 42a: other end edge 42b: Edge of one end of the region to be sealed at the other end 42c: Width of the other end seal 43: Simple seal part 44: Weakened Line 46: Notch 48: Applicator insertion opening 50: Applicator 52: Rod-shaped body 54: Liquid (liquid agent) holding section WL: Weakened line 60: Open outer bag 100: (Inventive) jig 110: Jig body 111: Bottom 112:Top surface 113Top opening 120: Bottomed groove 121: Wide section w 11 :Minimum width of wide section w 12 : Maximum width of the wide part d 1 :Depth of the wide section 122: Narrow section w 21 :Minimum width of narrow part w 22 : Maximum width of narrow part d 2 : Depth of narrow part 123: Rear seal relief notch 130: Laser marking opening

Claims

1. A "multi-component packaging device" comprising an "outer bag" and "two or more liquid agent packages" each having two main surfaces, front and back, substantially identical in shape and rectangular shape, the flat bag having one end and the other end, the outer bag being made of a heat-sealable laminated film or heat-sealable laminated sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, the outer bag being made of a pillow flat bag having one end sealed part, the other end sealed part and the outer bag back surface sealed part formed by heat sealing at one end, the other end and the back surface, respectively, and the two or more liquid agent packages being fixed and airtightly contained in a liquid agent package containing space, which is an internal space located near the other end of the outer bag. a "systematic liquid composition preparation kit" which is a material member of the outer bag, the other end of which is unjoined and open, and which holds the open outer bag and the two or more liquid agent packages in a "set and held state" in which the two or more liquid agent packages are arranged and held at predetermined positions in an area that will be the liquid agent package storage space of an "open outer bag," and then heat-seals the other end of the open outer bag to simultaneously join and seal the other end and fix the two or more liquid agent packages inside the outer bag, the jig being used to hold the open outer bag and the two or more liquid agent packages in the set and held state, The jig body is made of a block body having a bottom surface made of a flat surface and a top surface made of a flat surface arranged parallel to the bottom surface, and a bottomed groove having an opening on the top surface is formed therein. the bottomed groove is formed so that the open outer bag can be inserted and removed freely, and has a structure for holding the open outer bag and the two or more liquid agent packages in the set-completed holding state when one end edge of the open outer bag is inserted into the bottomed groove so as to abut against the groove bottom; the bottomed groove has a "wide portion" and a "narrow portion" formed so as to communicate with the wide portion in both length directions and downward of the wide portion; A direction along the edge of one end of the outer bag is defined as a length direction, a direction perpendicular to the length direction and from the edge of the one end toward the other end is defined as a height direction, and a direction perpendicular to the length direction and the height direction is defined as a thickness direction, The length (mm) of one end edge of the open outer bag is L １ The length (mm) of one end edge of each of the bags of the two or more liquid agent packages is L ２ year, The height (mm) from the bottom of the groove and the edge of one end of the open outer bag is H １ The height (mm) of the edge of one end of the region that will become the other end seal portion when the outer bag is made is H ２ The height (mm) of the lowest edge of one end of the bag in the two or more liquid drug packages is H ３ year, The thinnest thickness (mm) among the thicknesses (mm) W of the two or more liquid drug packages is W ｍｉｎ The sum of all thicknesses (mm) is W ａｌｌ year, The minimum width, maximum width, depth and length of the wide portion are respectively set as minimum width: w １１ , maximum width w １２ , depth d １ and length l １ The minimum width, maximum width, depth and length of the narrow portion are respectively set as minimum width: w ２１ , maximum width w ２２ , depth d ２ and length l ２ When The wide portion and the narrow portion are each selected from the following (1) to (7). (1) (thickness of one end of the opening outer bag) < w １１ = (or ≒) w ２２ <W ｍｉｎ (2) (thickness of one end of the opening outer bag) < w ２１ (3)W ａｌｌ <w １２ (4) (H ２ -H ３ )×0.1≦d １ <(H ２ -H ３ ) (5) d １ <d ２ (6) (d ２ -d １ )=(or ≒)H ３ (7) L ２ <l ２ <L １ <l １ Satisfy all the relationships shown in A tool for manufacturing a multi-component liquid composition preparation kit, comprising:

2. in the "set completion holding state", the two or more liquid agent packages are held at a position where, when the opening of the open outer bag is closed, the other end portions of all of the two or more liquid agent packages are sandwiched between the other end portions of the open outer bag facing each other, 2. The multi-component liquid composition preparation kit manufacturing jig of claim 1, wherein the narrow width portion and / or the wide width portion is provided with a rear seal relief notch to prevent the maximum opening width of the open outer bag from being narrowed by the outer bag rear seal portion near the other end of the open outer bag abutting against the inner surface of the upper region of the bottomed groove in the set and held state.

3. A jig for manufacturing a multi-component liquid composition preparation kit as described in claim 1 or 2, wherein the jig body has a basic shape consisting of a rectangular prism having rectangular top and bottom surfaces, and multiple bottomed grooves are arranged in a row at a predetermined interval along the longitudinal direction of the top surface.

4. A jig for manufacturing a multi-component liquid composition preparation kit as described in claim 3, wherein each of the multiple bottomed grooves arranged in a row at a predetermined interval along the longitudinal direction of the top surface of the jig body is arranged in a row so that the longitudinal direction of each bottomed groove is inclined at a certain angle within 1 to 3 degrees with respect to the longitudinal direction of the top surface.

5. A jig for manufacturing a multi-component liquid composition preparation kit as described in claim 3, wherein at least one of the longitudinal side surfaces of the jig body is provided with laser marking openings having a predetermined opening area that correspond to a plurality of bottomed grooves arranged in a row at a predetermined interval along the longitudinal direction of the upper surface of the jig body and communicate with each of the narrow width portions.

Images