Sample collection tool, method for manufacturing sample collection tool, and measurement system

Abstract

To provide a specimen sampling tool capable of surely sampling a specimen.SOLUTION: A specimen sampling tool includes a main body portion having an inner space portion for transferring a liquid specimen to the inside by a capillary phenomenon, the main body portion includes a plate-like portion formed in plate shape and a protruding portion that protrudes in a thickness direction of the plate-like portion from a first surface of the plate-like portion, and the inner space portion has a sampling port opened to the outside of the main body portion for sampling the specimen at a tip end of the protruding portion.SELECTED DRAWING: Figure 3

Description

[Technical field]

[0001] The present application relates to a specimen collecting device, a manufacturing method for the specimen collecting device, and a measurement system. [Background technology]

[0002] Conventionally, for example, a specimen collecting tool includes a plate-shaped portion formed in a plate shape, and the plate-shaped portion includes an internal space portion that transfers a liquid specimen (e.g., blood) to the inside by capillary action. The internal space portion includes a collection port that opens to the outside of the plate-shaped portion to collect the specimen. The collection port is disposed on the side peripheral surface of the plate-shaped portion (e.g., Patent Document 1).

[0003] Incidentally, methods of collecting a specimen include, for example, a method of sucking up a specimen on a surface (e.g., blood on the skin) from a collection port and a method of sucking up a specimen supplied by dropping it from above (e.g., from a syringe or bottle) from a collection port. However, in the specimen collection device of Patent Document 1, when collecting a specimen by the latter method, there is a possibility that the specimen will drip from the specimen collection device if, for example, too much specimen is supplied or an operator with low proficiency makes an incorrect operation. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2009-175118 A Summary of the Invention [Problem to be solved by the invention]

[0005] Therefore, an object of the present invention is to provide a specimen collecting device that can reliably collect a specimen, a method for manufacturing the specimen collecting device, and a measurement system. [Means for solving the problem]

[0006] The specimen collection device comprises a main body having an internal space that transports a liquid specimen inside by capillary action, the main body comprising a plate-shaped portion and a protrusion that protrudes in the thickness direction of the plate-shaped portion from a first surface of the plate-shaped portion, the internal space comprising a collection port at a tip of the protrusion that is open to the outside of the main body for collecting a specimen.

[0007] Furthermore, in the specimen collection device, the internal space may include a transport section extending from the collection port in the thickness direction inside the protrusion, a storage section for storing the specimen inside the plate-shaped section, and an opening that is open to the outside of the main body, wherein the transport section is connected to one end of the storage section when viewed in the thickness direction, and the opening is connected to the other end of the storage section when viewed in the thickness direction.

[0008] In addition, in the specimen collecting device, the internal space may include a transport section extending from the collection port in the thickness direction inside the protrusion, and a storage section for storing the specimen inside the plate-shaped section, the plate-shaped section including a first wall section and a second wall section separated in the thickness direction to form the storage section, the transport section being connected to the storage section by penetrating the first wall section, and the plate-shaped section including a guide section extending from the first wall section to the second wall section to guide the specimen from the transport section to the storage section.

[0009] In the specimen collecting tool, the surface of the guide portion may be smoothly continuous with the surface of the transport portion.

[0010] Furthermore, in the specimen collecting device, the internal space may be provided with a guide hole portion inside the first wall portion and the guide portion, the guide hole portion extending from the transport portion to the second wall portion, and the guide hole portion may be formed so that an opening cross-sectional area becomes smaller in a predetermined direction.

[0011] In the specimen collecting tool, the first surface of the plate-shaped portion may be provided with a recess around the protruding portion.

[0012] In the specimen collecting tool, at least a region of the plate-like portion which overlaps with the protruding portion when viewed in the thickness direction may be formed transparent, and the protruding portion may be formed transparent.

[0013] In addition, in the specimen collecting device, the internal space may have an opening that is open to the outside of the main body portion, and the opening may be located on a second surface of the plate-shaped portion that is opposite to the first surface.

[0014] The specimen collecting tool may further include a columnar portion connected to a side peripheral surface of the plate portion.

[0015] In addition, in the specimen collecting device, the plate-shaped portion may have a transparent portion on a second surface opposite to the first surface, which allows at least a portion of the specimen in the storage portion to pass through, and the columnar portion may protrude beyond the second surface of the plate-shaped portion in the thickness direction.

[0016] Further, a method for manufacturing a specimen collection device is the above-mentioned specimen collection device, wherein the internal space portion comprises a transport portion extending from the collection port in the thickness direction inside the protrusion, and a storage portion connected to the transport portion and for storing a specimen inside the plate-shaped portion, the method including preparing a base member having the protrusion and a transport opening constituting the transport portion, a layer member having a storage opening constituting the storage portion, and a membrane member covering the storage opening, fixing the base member and the layer member so that the transport opening and the storage opening are connected, and fixing the layer member and the membrane member so that the membrane member covers the storage opening.

[0017] The measurement system also includes the specimen collecting device and a measuring device that measures the specimen collected by the specimen collecting device. [Brief description of the drawings]

[0018] [Figure 1] FIG. 1 is an overall perspective view of a measurement system according to an embodiment. [Diagram 2] FIG. 2 is an internal view of region II in FIG. [Diagram 3] FIG. 3 is an overall perspective view of the specimen collecting tool according to the embodiment. [Figure 4] FIG. 4 is a perspective view of a main part of the specimen collecting tool according to the embodiment. [Diagram 5] FIG. 5 is an overall view of the specimen collecting tool according to the embodiment, where (a) is a side view and (b) is a bottom view. [Figure 6] FIG. 6 is an enlarged view of region VI in FIG. [Figure 7] 7 is a cross-sectional view of a main part taken along line VII-VII in FIG. [Figure 8] FIG. 8 is an enlarged view of region VIII in FIG. [Figure 9] FIG. 9 is an enlarged cross-sectional view taken along line IX-IX in FIG. [Figure 10] FIG. 10 is an enlarged cross-sectional view taken along line XX in FIG. [Figure 11] FIG. 11 is an enlarged view of area XI in FIG. [Figure 12] FIG. 12 is a cross-sectional view taken at the same position as FIG. 7, showing the state in which a specimen has been collected. [Figure 13] FIG. 13 is a cross-sectional view taken at the same position as FIG. 9, showing the state in which a specimen has been collected. [Figure 14] FIG. 14 is a diagram showing an example of a sampling method using the specimen sampling tool according to this embodiment. [Figure 15] FIG. 15 is a diagram showing another example of the sampling method using the specimen sampling tool according to this embodiment. [Figure 16] FIG. 16 is a diagram for explaining the manufacturing method of the specimen collecting device according to this embodiment, and is a perspective view seen from below. [Figure 17] FIG. 17 is a diagram for explaining the manufacturing method of the specimen collecting device according to this embodiment, and is a perspective view seen from below. [Figure 18] FIG. 18 is a cross-sectional view of a main portion of a specimen collecting tool according to another embodiment. [Figure 19] FIG. 19 is a cross-sectional view of a main portion of a specimen collecting tool according to still another embodiment. [Figure 20] FIG. 20 is a cross-sectional view of a main portion of a specimen collecting tool according to still another embodiment. [Figure 21] FIG. 21 is an enlarged cross-sectional view taken along line XXI-XXI in FIG. [Figure 22] FIG. 22 is a cross-sectional view of a main portion of a specimen collecting tool according to still another embodiment. [Figure 23] FIG. 23 is an enlarged view of area XXIII in FIG. [Figure 24] FIG. 24 is an enlarged cross-sectional view taken along line XXIV-XXIV in FIG. [Diagram 25] 25 is an enlarged cross-sectional view taken along line XXV-XXV in FIG. 24. FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0019] Hereinafter, one embodiment of the measurement system and specimen collecting tool will be described with reference to Figures 1 to 17. Note that in each figure (as well as Figures 18 to 25), the dimensional ratios in the drawings do not necessarily match the actual dimensional ratios, and the dimensional ratios between the drawings do not necessarily match either.

[0020] 1, the measurement system 100 includes a specimen collecting device 1 that collects a specimen, and a measuring device 101 that measures the specimen collected by the specimen collecting device 1. The measuring device 101 measures, for example, the concentration of a component in the specimen.

[0021] The specimen is not particularly limited as long as it is liquid, and examples of the specimen include body fluids such as blood, serum, plasma, saliva, urine, etc. The components measured by the measuring device 101 are not particularly limited, and examples of the components measured include glucose, cholesterol, free fatty acids, neutral fats, uric acid, lactic acid, etc.

[0022] 1 and 2, the measuring device 101 includes a measuring device main body 102 having an attachment port 102a to which the specimen collecting device 1 is attached, a measuring unit 103 that measures the specimen, a position detecting unit 104 that detects the position of the specimen collecting device 1, and a specimen specified amount detecting unit 105 that detects the amount of the specimen (specified amount) in the specimen collecting device 1. The measuring unit 103, the position detecting unit 104, and the specimen specified amount detecting unit 105 are each disposed inside the measuring device main body 102.

[0023] The configuration of the measurement unit 103 is not particularly limited, but in this embodiment, the measurement unit 103 includes a contact portion 103a that comes into contact with the specimen collecting tool 1 when measuring the specimen, and the contact portion 103a is formed in a convex spherical shape. Also, for example, when the specimen is blood and the measurement component is glucose, the measurement unit 103 includes, for example, an electrode and a treatment film that covers the electrode.

[0024] Specifically, after blood is separated into blood cells and plasma by a blood cell separation membrane provided in the specimen collecting device 1, only the plasma that has permeated the blood cell separation membrane is transferred onto the electrode. Then, glucose in the plasma is converted to hydrogen peroxide by an enzyme reaction membrane that covers the electrode, and the amount of hydrogen peroxide is measured on the electrode. That is, the specimen collecting device 1 according to this embodiment is a specimen collecting device 1 that collects a specimen as a measurement sample by electrochemical reaction.

[0025] The position detection section 104 detects whether or not the position of the specimen collecting tool 1 is appropriate. The configuration of the position detection section 104 is not particularly limited, but in this embodiment, the position detection section 104 includes a pair of electrodes 104a, 104a. When the position of the specimen collecting tool 1 with respect to the measuring device 101 is appropriate, electrical continuity is established between the pair of electrodes 104a, 104a.

[0026] The specified specimen amount detection unit 105 detects whether the amount of specimen collected by the specimen collecting tool 1 is appropriate. The configuration of the specified specimen amount detection unit 105 is not particularly limited, but in this embodiment, the specified specimen amount detection unit 105 includes a pair of electrodes 105a, 105a. When the amount of specimen collected by the specimen collecting tool 1 is appropriate, electrical continuity is established between the pair of electrodes 105a, 105a.

[0027] 3 to 6, the specimen collecting tool 1 is formed to be long. The specimen collecting tool 1 includes a main body section 2 and a columnar section 3 connected to the main body section 2. The main body section 2 includes a plate-shaped section 4 formed in a plate shape and a protruding section 5 protruding from the plate-shaped section 4.

[0028] In each drawing and the following description, the first direction D1 is referred to as the longitudinal direction D1 (of the main body 2 and the plate-like portion 4), the second direction D2 perpendicular to the first direction D1 is referred to as the lateral direction D2 (of the main body 2 and the plate-like portion 4), and the third direction D3 perpendicular to the first direction D1 and the second direction D2 is referred to as the thickness direction D3 (of the main body 2 and the plate-like portion 4). Depending on the shape of the specimen collecting tool 1, the first direction D1 may be the lateral direction and the second direction D2 may be the longitudinal direction.

[0029] The plate-shaped portion 4 has a first surface 4a facing a first side in the thickness direction D3 (the side indicated by the arrow in the thickness direction D3 in each drawing), a second surface 4b facing a second side in the thickness direction D3 (the side opposite to the arrow in the thickness direction D3 in each drawing), and a peripheral side surface 4c connecting the first surface 4a and the second surface 4b. The protrusion 5 protrudes from the first surface 4a of the plate-shaped portion 4 in the thickness direction D3. The first surface 4a of the plate-shaped portion 4 has a concave recess 4d around the protrusion 5.

[0030] The columnar portion 3 is connected to a side peripheral surface 4c of the plate-like portion 4. Specifically, the columnar portion 3 extends in a longitudinal direction D1 from the side peripheral surface 4c of the plate-like portion 4. The dimension of the columnar portion 3 in the thickness direction D3 is larger than the dimension of the plate-like portion 4 in the thickness direction D3.

[0031] The columnar portion 3 protrudes in the thickness direction D3 beyond the first surface 4a of the plate-shaped portion 4 and also protrudes beyond the second surface 4b of the plate-shaped portion 4. As a result, the specimen collecting tool 1 has a step between the columnar portion 3 and the first surface 4a of the plate-shaped portion 4, and also has a step between the columnar portion 3 and the second surface 4b of the plate-shaped portion 4.

[0032] The main body 2 also includes a detectable portion 2a that is detected by the position detection unit 104 (see FIG. 2). The configuration of the detectable portion 2a is not particularly limited, but in this embodiment, the detectable portion 2a is a conductor disposed on the second surface 4b of the plate-shaped portion 4. When the position of the specimen collecting tool 1 relative to the measuring device 101 is appropriate, the detectable portion 2a is connected to a pair of electrodes 104a, 104a of the position detection unit 104, respectively, and electrical continuity is established between the pair of electrodes 104a, 104a.

[0033] The main body 2 also includes a detection circuit 6 that constitutes a circuit detected by a specified specimen amount detection unit 105 (see FIG. 2). The configuration of the detection circuit 6 is not particularly limited, but in this embodiment, the detection circuit 6 includes a pair of conductive parts 6a, 6a that are conductive. The conductive part 6a includes a first terminal 6b that is disposed in an internal space 7 described below, and a second terminal 6c that is connected to an electrode 105a of the specified specimen amount detection unit 105.

[0034] When the amount of specimen collected by the specimen collecting tool 1 is appropriate, the first terminals 6b, 6b of the pair of conductive parts 6a, 6a are brought into electrical continuity by the specimen. As a result, electrical continuity is established between the pair of conductive parts 6a, 6a, and the detection circuit section 6 brings electrical continuity between the pair of electrodes 105a, 105a of the specimen specified amount detection section 105.

[0035] The main body 2 has an internal space 7 that transfers a specimen to the inside by capillary action. The internal space 7 has a sampling port 7a that is open to the outside of the main body 2 to sample a specimen, and an opening 7b that is open to the outside of the main body 2 to induce capillary action. The internal space 7 is open to the outside of the main body 2 only through the sampling port 7a and the opening 7b. The internal space 7 is a concept that includes the surfaces that make up the internal space.

[0036] The sampling port 7a is open in the thickness direction D3 of the plate-shaped portion 4. Specifically, the sampling port 7a is disposed at the tip of the protruding portion 5. This makes it possible to easily recognize the position of the sampling port 7a.

[0037] The opening 7b is disposed on the second surface 4b of the plate-shaped portion 4. As a result, the second surface 4b on which the opening 7b is disposed is the surface opposite to the first surface 4a on which the sampling port 7a is disposed. This makes it possible to prevent the opening 7b from being mistaken for the sampling port 7a.

[0038] The protrusion 5 includes a protruding body 5a having a truncated cone shape and a convex portion 5b that further protrudes from the tip of the protruding body 5a in the thickness direction D3. A pair of convex portions 5b are provided. The pair of convex portions 5b, 5b are spaced apart from each other in the longitudinal direction D1 to form a gap therebetween and are disposed to face each other in the longitudinal direction D1.

[0039] This forms a gap between the convex portions 5b, 5b, so that, for example, when the tip of the projection 5 comes into contact with the patient's skin, it is possible to prevent the collection port 7a from being sealed by the skin. Therefore, even when the tip of the projection 5, i.e., the convex portion 5b, is in contact with the patient's skin, blood passes through the gap between the convex portions 5b, 5b and is introduced into the collection port 7a. The number of the convex portions 5b is not particularly limited.

[0040] The protruding portion 5 is formed transparently. Moreover, the area of ​​the plate-shaped portion 4 that overlaps with the protruding portion 5 when viewed in the thickness direction D3 is formed transparently. Specifically, the plate-shaped portion 4 is formed transparently except for the detection target portion 2a and the detection circuit portion 6. This allows the position of the sampling port 7a to be recognized from the second surface 4b side of the plate-shaped portion 4.

[0041] Here, the configuration of the internal space 7 will be described with reference to FIGS.

[0042] 6 and 7, the internal space 7 includes a transfer section 7c extending from the sampling port 7a in the thickness direction D3 inside the protruding section 5, a storage section 7d connected to the end (downstream end) of the transfer section 7c and storing the specimen inside the plate-shaped section 4, and a buffer section 7e connected to the end (downstream end) of the storage section 7d and capable of storing the specimen. The buffer section 7e includes an opening 7b, which opens the buffer section 7e to the outside of the main body section 2.

[0043] The plate-shaped portion 4 includes a first wall portion 4e and a second wall portion 4f that are separated in the thickness direction D3 to form the storage portion 7d. The outer surface of the first wall portion 4e forms the first surface 4a of the plate-shaped portion 4, and the outer surface of the second wall portion 4f forms the second surface 4b of the plate-shaped portion 4.

[0044] The second wall 4f is configured to be permeable to a part of the specimen in the storage section 7d (in this embodiment, blood plasma). Thus, the plate-shaped section 4 is provided on the second surface 4b with a permeable section 4g (i.e., the second wall 4f) that allows a part of the specimen in the storage section 7d to pass therethrough. The permeable section 4g is formed in a deformable film shape.

[0045] The configuration of the permeation section 4g is not particularly limited, but in this embodiment, the permeation section 4g is a blood separation membrane that allows only plasma to pass through in order to separate blood cells and plasma from blood. In other words, although not particularly limited, the specimen collecting tool 1 according to this embodiment does not include a reagent in the internal space 7 to react with the specimen (blood).

[0046] In addition, the transfer section 7c is connected to the storage section 7d by penetrating the first wall section 4e of the plate-shaped section 4. That is, the first wall section 4e of the plate-shaped section 4 also constitutes the terminal section (downstream end section) of the transfer section 7c. However, since the first wall section 4e is separated from the second wall section 4f in the thickness direction D3, when the sample is transferred from the first wall section 4e to the second wall section 4f, for example, the transfer speed of the sample due to capillary action is slowed down.

[0047] Therefore, as shown in FIG. 8, the plate-shaped portion 4 is provided with a guide portion 4h extending from the first wall portion 4e toward the second wall portion 4f. The surface of the guide portion 4h is smoothly continuous with the surface of the transfer portion 7c without any step. As a result, the guide portion 4h guides the sample from the first wall portion 4e to the second wall portion 4f, so that the sample can be smoothly transferred from the transfer portion 7c to the storage portion 7d. Therefore, when the sample is transferred from the first wall portion 4e to the second wall portion 4f, the transfer speed of the sample can be prevented from slowing down.

[0048] 9, the transfer section 7c is connected to one end (upstream end) of the storage section 7d when viewed in the thickness direction D3. The open port 7b is connected to the other end (downstream end) of the storage section 7d when viewed in the thickness direction D3. Specifically, the other end of the storage section 7d is connected to a buffer section 7e having an open portion 7b. As a result, the specimen transferred from the transfer section 7c is transferred from one end to the other end of the storage section 7d, so that the specimen can be transferred throughout the entire area of ​​the storage section 7d.

[0049] In this embodiment, the specimen can be transferred throughout the entire area of ​​the storage section 7d by transferring the specimen to the first side in the longitudinal direction D1 (the side indicated by the arrow in the longitudinal direction D1 in each drawing). That is, it is not necessary to transfer the specimen to the second side in the longitudinal direction D1 (the side opposite to the arrow in the longitudinal direction D1 in each drawing).

[0050] In addition, when viewed in the thickness direction D3, the dimension W1 of the storage section 7d in the short direction D2 (the direction perpendicular to the sample transfer direction) increases toward the sample transfer direction (the first side of the longitudinal direction D1) and then decreases. This allows the sample to be transferred more reliably throughout the entire storage section 7d. The first terminal 6b of the conductive section 6a of the detection circuit section 6 is disposed on the distal end (downstream end) side of the storage section 7d.

[0051] Furthermore, in storage section 7d, measurement area 7h where the sample is measured is an area that contacts measurement section 103 (see FIG. 2). Although not particularly limited, in this embodiment, the maximum width W1 of measurement area 7h is the maximum value of the dimension W1 in the short side direction D2 of storage section 7d.

[0052] It is preferable that the distance W2 between the transport section 7c and the measurement region 7h is smaller than the maximum width W1 of the measurement region 7h when viewed in the thickness direction D3. With this configuration, the amount of sample required from the transport section 7c to the measurement region 7h is reduced. Therefore, the amount of sample required to measure the sample can be reduced.

[0053] Generally, the specimen is transported to the opening 7b by capillary action. At this time, since the opening 7b is separated from the reservoir 7d, a large amount of specimen is required to transport the specimen to the opening 7b.

[0054] 10 and 11, the buffer section 7e is provided with a suppression section 7f that suppresses the transfer of the sample from the storage section 7d. The suppression section 7f is connected to the end (downstream end) of the storage section 7d. In FIG. 11, the dashed line indicates the boundary between the storage section 7d and the buffer section 7e (suppression section 7f).

[0055] The dimension W3 of the inhibition portion 7f in the thickness direction D3 is larger than the dimension W4 of the end of the storage portion 7d in the thickness direction D3. This provides the internal space 7 with a step 7g between the inhibition portion 7f and the storage portion 7d. This prevents the sample from being transferred from the storage portion 7d to the inhibition portion 7f by capillary action. Although not particularly limited, the dimension W3 of the inhibition portion 7f is preferably 1.5 times or more, and more preferably 2 times or more, the dimension W4 of the end of the storage portion 7d at the step 7g.

[0056] Moreover, the hydrophilicity of the inhibition portion 7f is less than that of at least a portion of the storage portion 7d. That is, the hydrophilicity of the inhibition portion 7f (specifically, the average hydrophilicity of the entire inhibition portion 7f) is less than that of the storage portion 7d (specifically, the average hydrophilicity of the entire storage portion 7d). This can further inhibit the specimen from being transferred to the inhibition portion 7f, and therefore can effectively inhibit the specimen from being transferred from the storage portion 7d to the inhibition portion 7f.

[0057] For example, the hydrophilicity of the suppression portion 7f may be less than that of the entire area of ​​the storage portion 7d, but is not limited thereto. Also, for example, the hydrophilicity of the suppression portion 7f may be less than that of the upstream area of ​​the storage portion 7d and the same as that of the downstream area of ​​the storage portion 7d. Note that it is preferable that the hydrophilicity of the area of ​​the storage portion 7d that overlaps with the transfer portion 7c as viewed in the thickness direction D3 is greater than that of the suppression portion 7f.

[0058] In this way, even if the position of the opening 7b is away from the end of the storage section 7d, the transfer of the specimen can be stopped at the end of the storage section 7d. As a result, even if the specimen is transferred only by capillary action without centrifugation, the position of the opening 7b is not restricted by the end of the storage section 7d, so that there is a degree of freedom in designing the position of the opening 7b. The opening 7b communicates between the suppression section 7f and the outside of the main body section 2.

[0059] Next, the function of the buffer section 7e will be described with reference to FIGS.

[0060] The specimen transferred by capillary action (the colored parts in Figs. 12 and 13) fills the sampling port 7a, the transfer section 7c, and the storage section 7d, as shown in Figs. 12 and 13. However, for example, due to the head of the specimen in the transfer section 7c, the specimen in the transfer section 7c may leak into the storage section 7d.

[0061] Therefore, the volume of the buffer section 7e is larger than the volume of the transfer section 7c. As a result, when the sample in the transfer section 7c leaks into the storage section 7d, the buffer section 7e can accommodate the sample leaking from the storage section 7d. As a result, even if the sample in the transfer section 7c leaks into the storage section 7d due to the head of the sample in the transfer section 7c, the sample can be prevented from leaking from the open port 7b.

[0062] Furthermore, the contact portion 103a (see FIG. 2) of the measurement unit 103 of the measuring device 101 comes into contact with the transmission portion 4g of the plate-like portion 4 of the specimen collecting tool 1. Since the transmission portion 4g is formed in a deformable film shape, the transmission portion 4g may be deformed by the contact of the contact portion 103a with the transmission portion 4g, thereby reducing the volume of the storage portion 7d. Particularly in this embodiment, the contact portion 103a is formed in a convex spherical shape.

[0063] Therefore, the volume of the buffer section 7e is preferably 30% or more of the volume of the storage section 7d, and more preferably 50% or more. This allows the buffer section 7e to contain the sample leaked from the storage section 7d when the transmission section 4g is deformed and the volume of the storage section 7d is reduced, causing the sample to leak from the storage section 7d. This makes it possible to prevent the sample from leaking from the opening 7b.

[0064] Next, a method for collecting a specimen using the specimen collecting tool 1 will be described with reference to FIGS.

[0065] First, as shown in Fig. 14, by facing the sampling port 7a downward, a specimen on the surface, for example, blood on the skin, can be sucked up and collected from the sampling port 7a. The area of ​​the plate-shaped part 4 that overlaps with the protruding part 5 when viewed in the thickness direction D3 and the protruding part 5 are formed transparent. This allows the position of the sampling port 7a to be easily recognized from the second surface 4b side of the plate-shaped part 4, making it easy to collect a specimen.

[0066] When collecting a specimen, the columnar portion 3 may be grasped. Since the columnar portion 3 is connected to the side peripheral surface 4c of the plate-like portion 4, for example, the direction (upward, downward) of the collection port 7a can be easily changed by pinching the columnar portion 3 with fingers and rotating it. This makes it possible to easily collect a specimen and attach the specimen collecting tool 1 to a measuring device 101 (see FIG. 1), for example.

[0067] Furthermore, since the collection port 7a is open in the thickness direction D3, as shown in FIG. 15, by pointing the collection port 7a upward, a specimen supplied by dropping from above, for example a specimen supplied by dropping from a syringe X1 (or a bottle, etc.), can be sucked up and collected through the collection port 7a.

[0068] At this time, even if the sample leaks from the collection port 7a, the plate-shaped portion 4 can receive the sample. Moreover, since the first surface 4a of the plate-shaped portion 4 has the protrusion 5, i.e., the recess 4d (see FIG. 3) around the collection port 7a, the leaked sample can be retained in the recess 4d. This makes it possible to prevent the sample from dripping from the sample collecting tool 1. In this way, the sample can be reliably collected in either collection method.

[0069] In addition, since the columnar portion 3 protrudes from the second surface 4b of the plate-shaped portion 4, when the specimen collecting tool 1 is placed on the mounting surface X2 with the second surface 4b of the plate-shaped portion 4 facing downward, the end of the second surface 4b of the plate-shaped portion 4 and the columnar portion 3 are supported by the mounting surface X2. As a result, the transmission portion 4g, which is important for the measurement, is separated from the mounting surface X2, so that the transmission portion 4g can be prevented from contacting the mounting surface X2. Note that a configuration in which only the columnar portion 3 is supported by the mounting surface X2 and the entire second surface 4b of the plate-shaped portion 4 is separated from the mounting surface X2 may also be used.

[0070] In addition, since the sampling port 7a is provided at the tip of the protruding portion 5 protruding from the first surface 4a of the plate-shaped portion 4, rather than on the first surface 4a of the plate-shaped portion 4, the area that comes into contact with the sample can be reduced. This makes it possible to prevent, for example, the measuring device 101 (see FIGS. 1 and 2) from being contaminated by the sample.

[0071] Next, a method for manufacturing the specimen collecting tool 1 will be described with reference to FIGS.

[0072] The number of components constituting the specimen collecting tool 1 is not particularly limited, but the specimen collecting tool 1 according to this embodiment is composed of three components 11-13, as shown in Figures 16 and 17. The three components 11-13 include a base member 11 constituting most of the columnar section 3 and the plate-like section 4, a layer member 12 constituting part of the storage section 7d and the inhibition section 7f, and a membrane member 13 constituting the transmission section 4g (second wall section 4f).

[0073] The material of the base member 11 is not particularly limited, but may be, for example, a synthetic resin (e.g., polycarbonate). The material of the membrane member 13 is not particularly limited, but may be, for example, a synthetic resin (e.g., polycarbonate) that allows plasma from blood to pass through.

[0074] The surfaces of the base member 11 constituting the transfer section 7c and the storage section 7d are subjected to a hydrophilic treatment, and the surface of the membrane member 13 constituting the storage section 7d is also subjected to a hydrophilic treatment. This can promote the transfer of the specimen in the transfer section 7c and the storage section 7d. Although not particularly limited, the hydrophilic treatment can be, for example, a coating treatment using a surfactant (e.g., 29-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol, polyoxyethylene sorbitan monolaurate, polyoxyethylene lauryl ether, polyvinylpyrrolidone, etc.).

[0075] The base member 11 has, on one side thereof, for example, a buffer recess 11a constituting the buffer portion 7e and a guide protrusion 11b constituting the guide portion 4h. The buffer recess 11a is formed in a bottomed concave shape and has a suppression recess 11c constituting the suppression portion 7f. The base member 11 also has a protrusion 5 (not shown in Figs. 16 and 17) protruding from the other side thereof, and the protrusion 5 has a transfer opening 11d constituting the transfer portion 7c.

[0076] Furthermore, since the guide protrusion 11b is provided on the base member 11, regardless of the position of the layer member 12 relative to the base member 11 (for example, even if the position of the layer member 12 is shifted from the appropriate position), the surface of the guide portion 4h is smoothly continuous with the surface of the conveying portion 7c without any steps (see Figure 8).

[0077] The protruding amount of the guide projection 11b may be greater than the thickness of the layer member 12. This allows the guide portion 4h to reliably abut against the second wall portion 4f of the plate-shaped portion 4 that constitutes the storage portion 7d (see FIG. 8).

[0078] The layer member 12 also includes a storage opening 12a constituting the storage portion 7d and a suppression opening 12b constituting the suppression portion 7f. The storage opening 12a and the suppression opening 12b each penetrate the layer member 12 in the thickness direction. The storage opening 12a is connected to the suppression opening 12b. The material of the layer member 12 is not particularly limited, but may be, for example, a resin having adhesive properties.

[0079] Therefore, first, the base member 11, the layer member 12, and the film member 13 are prepared (preparation step). Then, since the layer member 12 serves as an adhesive layer, the layer member 12 is adhered to the base member 11, as shown in Fig. 16, thereby fixing the base member 11 and the layer member 12 together (first fixing step).

[0080] At this time, the transfer opening 11d of the base member 11 is connected to the storage opening 12a of the layer member 12. Moreover, the suppression recess 11c of the base member 11 is connected to the suppression opening 12b of the layer member 12. As a result, the suppression opening 12b and the buffer opening 11a form the suppression portion 7f, and a step 7g is formed between the suppression portion 7f and the storage portion 7d. In addition, in FIG. 16, the dashed line indicates the boundary between the storage opening 12a and the suppression opening 12b.

[0081] 17, the layer member 12 and the membrane member 13 are fixed to each other by adhering the membrane member 13 to the layer member 12 (second fixing step). As a result, the storage opening 12a and the suppression opening 12b of the layer member 12 are covered by the membrane member 13. In this manner, the specimen collecting tool 1 is manufactured.

[0082] The manufacturing method of the specimen collecting tool 1 is not particularly limited. For example, the specimen collecting tool 1 may be manufactured from one, two, or four or more members. In addition, the layer member 12 may not have adhesive properties, and the members 11, 12, and 13 may be fixed to each other, for example, by an adhesive or the like, or may be fixed by thermal welding, for example. In addition, the order of fixing the base member 11 and layer member 12 and fixing the layer member 12 and film member 13 is not particularly limited.

[0083] As described above, the specimen collection device 1 of this embodiment comprises a main body 2 having an internal space 7 that transports a liquid specimen to its interior by capillary action, and the main body 2 comprises a plate-shaped portion 4 formed in a plate shape and a protrusion 5 that protrudes from a first surface 4a of the plate-shaped portion 4 in the thickness direction D3 of the plate-shaped portion 4, and the internal space 7 comprises a collection port 7a at the tip of the protrusion 5 that is open to the outside of the main body 2 to collect a specimen.

[0084] According to this configuration, the sampling port 7a is provided at the tip of the protruding portion 5. With this, by facing the sampling port 7a upward, the specimen supplied by dropping from above can be sucked up and collected through the sampling port 7a. At this time, the plate-shaped portion 4 receives the specimen, so that the specimen can be prevented from dripping from the specimen collecting tool 1. On the other hand, by facing the sampling port 7a downward, the specimen on the surface can be sucked up and collected through the sampling port 7a.

[0085] In this way, the specimen can be reliably collected in either collection method. Moreover, the protruding portion 5 protrudes from the first surface 4a of the plate-shaped portion 4 in the thickness direction D3, and the collection port 7a is disposed at the tip of the protruding portion 5. This makes it easy to recognize the position of the collection port 7a.

[0086] Furthermore, in the specimen collecting device 1 of this embodiment, the internal space 7 comprises a transport section 7c extending from the collection port 7a in the thickness direction D3 inside the protrusion 5, a storage section 7d for storing the specimen inside the plate-shaped section 4, and an opening 7b that is open to the outside of the main body section 2, and the transport section 7c is connected to one end of the storage section 7d when viewed in the thickness direction D3, and the opening 7b is connected to the other end of the storage section 7d when viewed in the thickness direction D3.

[0087] According to this configuration, the transfer section 7c extends from the collection port 7a in the thickness direction D3 inside the protrusion 5. When viewed in the thickness direction D3, the transfer section 7c is connected to one end of the storage section 7d, and the opening 7b is connected to the other end of the storage section 7d. As a result, the specimen transferred from the transfer section is transferred from one end to the other end of the storage section. Therefore, the specimen can be transferred throughout the entire area of ​​the storage section 7d.

[0088] In the specimen collecting device 1 according to this embodiment, the internal space 7 includes a transfer section 7c extending from the collection port 7a inside the protrusion 5 in the thickness direction D3, and a storage section 7d for storing the specimen inside the plate-shaped section 4, the plate-shaped section 4 includes a first wall section 4e and a second wall section 4f which are separated in the thickness direction D3 to form the storage section 7d, the transfer section 7c is connected to the storage section 7d by penetrating the first wall section 4e, and the plate-shaped section 4 includes a guide section 4h extending from the first wall section 4e to the second wall section 4f to guide the specimen from the transfer section 7c to the storage section 7d.

[0089] According to this configuration, the guide portion 4h extends from the first wall portion 4e through which the transfer portion 7c penetrates to the second wall portion 4f. As a result, the guide portion 4h guides the sample from the first wall portion 4e to the second wall portion 4f, that is, guides the sample from the transfer portion 7c to the storage portion 7d. Therefore, the sample can be smoothly transferred from the transfer portion 7c to the storage portion 7d.

[0090] Furthermore, in the specimen collecting tool 1 according to this embodiment, the surface of the guide portion 4h is smoothly continuous with the surface of the transport portion 7c.

[0091] According to this configuration, the surface of the guide section 4h is smoothly connected to the surface of the transfer section 7c. This allows the sample to be guided from the transfer section 7c to the storage section 7d. Therefore, the sample can be more smoothly transferred from the transfer section 7c to the storage section 7d.

[0092] Moreover, in the specimen collecting tool 1 according to this embodiment, the first surface 4a of the plate-like portion 4 is provided with a recess 4d around the protruding portion 5.

[0093] According to this configuration, if the sample leaks from the sampling port 7a when the sampling port 7a is facing upward, the leaked sample can be retained in the recess 4d, thereby effectively preventing the sample from dripping from the sample sampling tool 1.

[0094] Furthermore, in the specimen collecting device 1 of this embodiment, at least the area of ​​the plate-shaped portion 4 that overlaps with the protrusion 5 when viewed in the thickness direction D3 is formed transparent, and the protrusion 5 is formed transparent.

[0095] According to this configuration, at least the region of the plate-shaped portion 4 that overlaps with the protruding portion 5 when viewed in the thickness direction D3, and the protruding portion 5 are formed transparent. This makes it easy to recognize the position of the sampling port 7a when sampling a sample from the sampling port 7a with the sampling port 7a facing downward.

[0096] Furthermore, in the specimen collecting device 1 of this embodiment, the internal space 7 has an opening 7b that is open to the outside of the main body 2, and the opening 7b is located on the second surface 4b, which is the surface opposite to the first surface 4a of the plate-shaped portion 4.

[0097] According to this configuration, the sampling port 7a is disposed at the tip of the protruding portion 5 protruding from the first surface 4a of the plate-shaped portion 4, while the open port 7b is disposed on the second surface 4b, which is the surface opposite to the first surface 4a of the plate-shaped portion 4. This makes it possible to prevent the open port 7b from being mistaken for the sampling port 7a.

[0098] The specimen collecting tool 1 according to this embodiment is further configured to include a columnar portion 3 connected to the side peripheral surface 4c of the plate-shaped portion 4.

[0099] According to this configuration, since the columnar portion 3 is connected to the side peripheral surface 4c of the plate-shaped portion 4, the orientation of the sampling port 7a can be easily changed, for example, by operating the columnar portion 3 to rotate it.

[0100] Furthermore, in the specimen collecting device 1 according to this embodiment, the plate-like portion 4 is provided with a transparent portion 4g on a second surface 4b opposite to the first surface 4a, which allows at least a portion of the specimen in the storage portion 7d to pass through, and the columnar portion 3 protrudes beyond the second surface 4b of the plate-like portion 4 in the thickness direction D3.

[0101] According to this configuration, the columnar portion 3 protrudes beyond the second surface 4b of the plate-shaped portion 4 in the thickness direction D3. As a result, for example, when the specimen collecting tool 1 is placed on a flat mounting surface X2 with the second surface 4b of the plate-shaped portion 4 facing downward, the transmission portion 4g can be separated from the mounting surface X2. Therefore, it is possible to prevent the transmission portion 4g from contacting the mounting surface X2.

[0102] Furthermore, a manufacturing method of the specimen collecting device 1 according to this embodiment is the specimen collecting device 1 described above, and the internal space portion 7 includes a transport portion 7c extending from the collection port 7a in the thickness direction D3 inside the protruding portion 5, and a storage portion 7d connected to the transport portion 7c and for storing a specimen inside the plate-shaped portion 4, the manufacturing method including the steps of preparing a base member 11 having the protruding portion 5 and a transport opening 11d constituting the transport portion 7c, a layer member 12 having a storage opening 12a constituting the storage portion 7d, and a membrane member 13 covering the storage opening 12a, fixing the base member 11 and the layer member 12 so that the transport opening 11d and the storage opening 12a are connected, and fixing the layer member 12 and the membrane member 13 so that the membrane member 13 covers the storage opening 12a.

[0103] The specimen collecting tool 1, the manufacturing method of the specimen collecting tool 1, and the measurement system 100 are not limited to the configurations of the above-mentioned embodiments, and are not limited to the above-mentioned effects. Of course, the specimen collecting tool 1, the manufacturing method of the specimen collecting tool 1, and the measurement system 100 can be modified in various ways without departing from the gist of the present invention. For example, it is of course possible to arbitrarily select one or more of the configurations and methods according to the various modified examples described below and adopt them in the configurations and methods according to the above-mentioned embodiments.

[0104] (1) In the specimen collecting tool 1 according to the above embodiment, the internal space 7 is provided with a stopper 7f that stops the specimen from being transferred from the storage section 7d. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to such a configuration. For example, the internal space 7 may not include the stopper 7f, and the opening 7b may be connected to the end of the storage section 7d.

[0105] (2) In the specimen collecting tool 1 according to the above embodiment, the transport section 7c is connected to an end of the storage section 7d when viewed in the thickness direction D3. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to this configuration. For example, the transport section 7c may be connected to a position away from the end of the storage section 7d (for example, the center of the storage section 7d) when viewed in the thickness direction D3.

[0106] (3) In the specimen collecting tool 1 according to the above embodiment, the plate-shaped portion 4 includes a guide portion 4h extending from the first wall portion 4e to the second wall portion 4f, and the surface of the guide portion 4h is smoothly continuous with the surface of the transport portion 7c. However, although such a configuration is preferable for the specimen collecting tool 1, the configuration is not limited to this. For example, the plate-shaped portion 4 may not include a guide portion 4h. Also, for example, the surface of the guide portion 4h may be continuous with the surface of the transport portion 7c with a step.

[0107] (4) In the specimen collecting device 1 according to the above embodiment, the plate-shaped portion 4 is transparent except for the detection target portion 2a and the detection circuit portion 6, and the protruding portion 5 is transparent. However, the specimen collecting device 1 is not limited to this configuration. For example, the plate-shaped portion 4 may be transparent only in the area that overlaps with the protruding portion 5 when viewed in the thickness direction D3. Furthermore, at least one of the plate-shaped portion 4 and the protruding portion 5 may be opaque.

[0108] (5) In the specimen collecting device 1 according to the above embodiment, the first surface 4a of the plate-shaped portion 4 is configured to have a recess 4d around the protruding portion 5. However, although such a configuration is preferable, the specimen collecting device 1 is not limited to this configuration. For example, the first surface 4a of the plate-shaped portion 4 may be flat all around the protruding portion 5, i.e., may not have a recess 4d.

[0109] (6) In the specimen collecting device 1 according to the above embodiment, the first surface 4a of the plate-shaped portion 4 is configured to have a recess 4d formed by recessing around the protruding portion 5. However, the specimen collecting device 1 is not limited to this configuration. For example, as shown in Fig. 18, the plate-shaped portion 4 may have an annular protruding portion 4i that protrudes in a ring shape from the first surface 4a to surround the protruding portion 5, and the recessed portion 4d may be formed inside the annular protruding portion 4i.

[0110] (7) In the specimen collecting tool 1 according to the above embodiment, the opening 7b is disposed on the second surface 4b of the plate-shaped portion 4, i.e., on the surface 4a opposite to the sampling port 7a. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to such a configuration. For example, the opening 7b may be disposed on the first surface 4a of the plate-shaped portion 4, i.e., on the surface 4a on the same side as the sampling port 7a. Also, for example, the opening 7b may be disposed on the side peripheral surface 4c of the plate-shaped portion 4.

[0111] (8) Furthermore, the specimen collecting tool 1 according to the above embodiment is configured to include a columnar portion 3 connected to the side peripheral surface 4c of the plate-like portion 4. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to such a configuration. For example, the specimen collecting tool 1 may be configured not to include a columnar portion 3, and may be formed so that the entirety of the specimen collecting tool 1 is plate-like.

[0112] (9) In the specimen collecting tool 1 according to the above embodiment, the columnar portion 3 protrudes from the second surface 4b of the plate-like portion 4 in the thickness direction D3. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to this configuration. For example, the columnar portion 3 may be smoothly continuous with the second surface 4b of the plate-like portion 4 in the thickness direction D3 without any step. Also, for example, the columnar portion 3 may be recessed from the second surface 4b of the plate-like portion 4 in the thickness direction D3.

[0113] (10) In the specimen collecting tool 1 according to the above embodiment, the internal space 7 has a step 7g between the storage portion 7d and the inhibiting portion 7f. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to this configuration. For example, as shown in FIG. 19, the internal space 7 may not have a step 7g between the storage portion 7d and the inhibiting portion 7f, and the dimension W3 in the thickness direction D3 of the inhibiting portion 7f may be gradually larger than the dimension W4 in the thickness direction D3 of the end portion of the storage portion 7d.

[0114] (11) In the specimen collecting tool 1 according to the above embodiment, the volume of the buffer section 7e is larger than the volume of the transport section 7c. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to this configuration. For example, the volume of the buffer section 7e may be equal to or smaller than the volume of the transport section 7c.

[0115] (12) In the specimen collecting tool 1 according to the above embodiment, the volume of the buffer section 7e is 30% or more of the volume of the storage section 7d. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to this configuration. For example, the volume of the buffer section 7e may be less than 30% of the volume of the storage section 7d.

[0116] (13) In the specimen collecting tool 1 according to the above embodiment, the transmission section 4g is formed in a deformable film shape. However, the specimen collecting tool 1 is not limited to this configuration. For example, the transmission section 4g may be rigid enough to be undeformable.

[0117] (14) In the specimen collecting tool 1 according to the above embodiment, the transmission section 4g is configured to transmit a part of the specimen in the storage section 7d. However, the specimen collecting tool 1 is not limited to such a configuration. For example, the transmission section 4g may be configured to transmit the entire specimen in the storage section 7d.

[0118] (15) In addition, in the specimen collecting tool 1 according to the above embodiment, the hydrophilicity of the inhibiting portion 7f is less than the hydrophilicity of at least a part of the storage portion 7d. However, although such a configuration is preferable, the specimen collecting tool 1 is not limited to this configuration. For example, the hydrophilicity of the inhibiting portion 7f may be the same as that of the storage portion 7d. Also, for example, the hydrophilicity of the inhibiting portion 7f may be greater than that of the storage portion 7d.

[0119] (16) In addition, in the specimen collecting tool 1 according to the above embodiment, the transport section 7c is configured to be separated from the measurement region 7h when viewed in the thickness direction D3. However, the specimen collecting tool 1 is not limited to this configuration. For example, as shown in Figs. 20 and 21, a configuration in which the transport section 7c is connected to the measurement region 7h when viewed in the thickness direction D3 is preferable. That is, a configuration in which the distance W2 (see Fig. 9) between the transport section 7c and the measurement region 7h is zero is preferable. With this configuration, the amount of specimen required to measure the specimen can be significantly reduced.

[0120] (17) Furthermore, in the specimen collecting device 1, as shown in FIGS. 22 to 25, the internal space 7 may be provided with a guide hole 7i extending from the transport section 7c to the second wall section 4f inside the first wall section 4e and the guide section 4h, and the guide hole 7i may be formed so that the opening cross-sectional area becomes smaller in a predetermined direction.

[0121] According to this configuration, the guide hole 7i extends from the transfer section 7c to the second wall section 4f, and the opening cross-sectional area of ​​the guide hole 7i becomes smaller in a predetermined direction. This allows the specimen to be transferred in the predetermined direction inside the guide hole 7i by capillary action. Therefore, the specimen can be smoothly transferred from the transfer section 7c to the second wall section 4f.

[0122] The plate-like portion 4 according to Fig. 22 to Fig. 25 includes a first surface 4j facing the second wall portion 4f in the thickness direction D3, and a pair of second surfaces 4k, 4k extending from the first surface 4j in the thickness direction D3 to the second wall portion 4f and facing each other in the short direction D2. The guide hole portion 7i is formed by the first surface 4j, the pair of second surfaces 4k, 4k, and the second wall portion 4f. The first surface 4j and the second surface 4k are disposed across the first wall portion 4e and the guide portion 4h.

[0123] The distance in the thickness direction D3 between the first surface 4j and the second wall portion 4f decreases toward one side in the longitudinal direction D1 (the arrow direction side in the longitudinal direction D1 in Figs. 22 to 25), and the distance in the short direction D2 between the pair of second surfaces 4k, 4k is constant over the longitudinal direction D1. As a result, the opening cross-sectional area of ​​the guide hole portion 7i decreases toward one side in the longitudinal direction D1.

[0124] The opening cross-sectional area is the cross-sectional area of ​​the internal space formed inside the guide hole 7i, and is the area of ​​the internal space in a cross section of a virtual plane perpendicular to a predetermined direction (longitudinal direction D1 in Figs. 22 to 25). That is, in Figs. 22 to 25, the opening cross-sectional area of ​​the end portion on the upstream side (the other side in the longitudinal direction D1 (the side opposite to the arrow direction of the longitudinal direction D1 in Figs. 22 to 25)) of the guide hole 7i is smaller than the opening cross-sectional area of ​​the end portion on the downstream side of the transfer section 7c (the side opposite to the arrow direction of the thickness direction D3 in Figs. 22 to 25). [Explanation of symbols]

[0125] 1...Specimen collection tool, 2...Body part, 2a...Detected part, 3...Column-shaped part, 4...Plate-shaped part, 4a...First surface, 4b...Second surface, 4c...Side peripheral surface, 4d...Concave part, 4e...First wall part, 4f...Second wall part, 4g...Transparent part, 4h...Guiding part, 4i...Annular convex part, 4j...First surface, 4k...Second surface , 5...Protrusion part, 5a...Protrusion body part, 5b...Convex part, 6...Detection circuit part, 6a...Conductive part, 6b...First terminal, 6c...Second terminal, 7...Inner space part, 7a...Sampling port, 7b...Opening port, 7c...Transfer part, 7d...Storage part, 7e...Buffer part, 7f...Suppression part, 7g...Step, 7h...Measurement Region, 7i...guide hole portion, 11...base member, 11a...buffer recess, 11b...guide protrusion, 11c...restraint recess, 11d...transfer opening, 12...layer member, 12a...storage opening, 12b...restraint opening, 13...membrane member, 100...measurement system, 101...measuring device, 102...measuring device main body, 102a...mounting port, 103...measurement section, 103a...contact section, 104...position detection section, 104a...electrode, 105...specimen specified amount detection section, 105a...electrode, D1...longitudinal direction, D2...transverse direction, D3...thickness direction, X1...syringe, X2...mounting surface

Claims

1. a main body having an internal space into which a liquid sample is transported by capillary action; The main body portion includes a plate-shaped portion formed in a plate shape and a protruding portion protruding from a first surface of the plate-shaped portion in a thickness direction of the plate-shaped portion, The internal space portion has a collection port at a tip of the protrusion, the collection port being open to the outside of the main body portion in order to collect a specimen. The internal space portion includes a transport portion extending in the thickness direction from the collection port inside the protrusion portion, a reservoir section for storing a specimen inside the plate-shaped section, and an opening opening for opening to the outside of the main body section, The transport portion is connected to one end of the storage portion when viewed in the thickness direction, The opening is connected to the other end of the storage portion when viewed in the thickness direction.

2. The internal space includes a transport section extending from the sampling port in the thickness direction inside the protrusion, and a storage section for storing a sample inside the plate-shaped section, The plate-shaped portion includes a first wall portion and a second wall portion that are separated in the thickness direction to form the storage portion, The transfer section is connected to the storage section by penetrating the first wall section, The specimen collecting device according to claim 1 , wherein the plate-shaped portion includes a guide portion extending from the first wall portion to the second wall portion for guiding the specimen from the transport portion to the storage portion.

3. The specimen collecting device according to claim 2 , wherein the surface of the guide portion is smoothly continuous with the surface of the transport portion.

4. The internal space includes a guide hole portion extending from the transport portion to the second wall portion inside the first wall portion and the guide portion, 4. The specimen collecting tool according to claim 2, wherein the guide hole portion is formed so that an opening cross-sectional area thereof decreases in a predetermined direction.

5. The specimen collecting device according to claim 1 , wherein the first surface of the plate-shaped portion is provided with a recess around the protruding portion.

6. At least a region of the plate-like portion that overlaps with the protruding portion when viewed in the thickness direction is formed to be transparent, The specimen collecting tool according to any one of claims 1 to 5, wherein the protrusion is formed to be transparent.

7. A specimen collection device as described in any one of claims 1 to 6, wherein the opening is located on a second surface, which is the surface opposite to the first surface of the plate-shaped portion.

8. 8. The specimen collecting tool according to claim 1, further comprising a columnar portion connected to a side peripheral surface of the plate-shaped portion.

9. the plate-shaped portion includes a transmission portion on a second surface opposite to the first surface, the transmission portion transmitting at least a part of the specimen in the storage portion; The specimen collecting tool according to claim 8 , wherein the columnar portion protrudes beyond the second surface of the plate portion in the thickness direction.

10. A method for manufacturing the specimen collecting device according to any one of claims 1 to 9, Preparing a base member having the protrusion and a transfer opening constituting the transfer section, a layer member having a storage opening constituting the storage section, and a film member covering the storage opening; Fixing the base member and the layer member so that the transfer opening and the storage opening are adjacent to each other; and fixing the layer member and the membrane member so that the membrane member covers the storage opening.

11. A specimen collecting device according to any one of claims 1 to 9, A measurement system comprising: a measuring device that measures the sample collected by the sample collecting device.

Images