Clip apparatus, clip device and method for unlocking clip

Abstract

A clip apparatus (10), a clip device (1) and a method for unlocking a clip, the clip apparatus (10) comprising a clip (400) and a storage tube (500), the clip (400) comprising a clip arm, the clip arm comprising a first clip arm (410) and a second clip arm (420), a distal end of the first clip arm (410) and a distal end of the second clip arm (420) being used for ligation, the storage tube (500) comprising a channel, a proximal end of the first clip arm (410) and a proximal end of the second clip arm (420) being receivable within the channel, and the clip ( When clip (400) is in the locked state, the distal end of first clip arm (410) and the distal end of second clip arm (420) remain closed and the storage tube (500) restricts the movement of limiting clip (400) toward the distal end relative to the storage tube (500); when clip (400) is switched from the locked state to the unlocked state, the restriction on movement of clip (400) by storage tube (500) is released and the distal end of first clip arm (410) and the distal end of second clip arm (420) can open again.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to Chinese Application No. 202110043045.7, filed on January 13, 2021, and Chinese Application No. 202110874523.9, filed on July 30, 2021, the entire contents of which are incorporated herein by reference.

[0002] The present application relates to the field of medical devices, and in particular to a clipping device, a clipping device and a method for unlocking a clip. [Background technology]

[0003] The stomach and intestines of living organisms often bleed due to various diseases, accidental injury, or injury after endoscopic treatment. Active bleeding can be treated by mechanical compression hemostasis using a hemostatic clip. Hemostasis by mechanical compression of a hemostatic clip is effective in treating active bleeding caused by factors other than varicose veins, and is recognized by doctors and patients. Hemostatic clips can also close mucosal damage in the digestive tract to some extent and promote wound healing. However, once a clip device is locked, the locking relationship cannot be released without damage, and the clamping part can only be forcibly separated from the tissue by a removal method that involves violent destruction, which can cause secondary damage to the tissue or rebleeding. Summary of the Invention

[0004] Therefore, it is necessary to propose a clip apparatus, a clip device and a clip unlocking method that can solve the problem that after the clip is locked, it can only be removed by violent destruction.

[0005] In one aspect of the present specification, there is provided a clip device comprising a clip and a storage tube, the clip comprising a clip arm, the clip arm comprising a first clip arm and a second clip arm, a distal end of the first clip arm and a distal end of the second clip arm are used for ligation, the storage tube comprises a channel, a proximal end of the first clip arm and a proximal end of the second clip arm are retractable within the channel, the clip is switchable from a locked state to an unlocked state, when the clip is in the locked state, the distal end of the first clip arm and the distal end of the second clip arm remain closed and the storage tube restricts the clip from moving distally relative to the storage tube, and when the clip is switched from the locked state to the unlocked state, the storage tube is released from the restriction on movement of the clip and the distal end of the first clip arm and the distal end of the second clip arm can open again.

[0006] In some embodiments, the clip includes a locking portion, the locking portion connected to the clip arm, the storage tube includes an outer wall and a locking portion, the locking portion is restricted from moving distally relative to the outer wall, and when the clip is in the locked state, the locking portion and the locked portion cooperate to form a restriction of movement of the clip by the storage tube.

[0007] In some embodiments, when the cooperation between the locking portion and the locked portion is released, the restriction of movement of the clip by the storage tube is released and the clip is switched from the locked state to the unlocked state.

[0008] In some embodiments, when the locking portion is distorted, broken or displaced, the cooperation between the locking portion and the locked portion is released.

[0009] In some embodiments, the locking portion includes an elastic piece having a first end, a second end and a third end of the elastic piece, the first end of the elastic piece being connected to the outer wall of the storage tube, the second end of the elastic piece being provided at a proximal end of the first end of the elastic piece, and the third end of the elastic piece being provided at a distal end of the first end of the elastic piece, and the second end of the elastic piece constituting the locking portion.

[0010] In some embodiments, when the clip is in the locked state, the second end of the elastic piece extends into the channel and the third end of the elastic piece extends outside the outer wall, and when the clip is switched from the locked state to the unlocked state, the second end of the elastic piece extends outside the outer wall and the third end of the elastic piece extends into the channel.

[0011] In some embodiments, when the locked portion is distorted, broken or displaced, the cooperation between the locking portion and the locked portion is released.

[0012] In some embodiments, the locked portion includes a connecting pin that is connected to the clip arm, and when the connecting pin is subjected to a force and compressed radially, the cooperative relationship between the locking portion and the locked portion is released.

[0013] In some embodiments, the connection pin includes a movable end and a spring connected to the movable end, and when the movable end receives a force and compresses the spring in a radial direction, the radial dimension of the connection pin becomes smaller than the spacing of the locking portions.

[0014] In some embodiments, the clip arm includes a protrusion provided at a proximal end of the clip arm, the protrusion constituting the locked portion, and when the protrusion is subjected to a force and displaced radially, the cooperative relationship between the locking portion and the locked portion is released.

[0015] In some embodiments, the protrusion includes a first protrusion provided on the proximal end of the first clip arm and a second protrusion provided on the proximal end of the second clip arm, the first protrusion and the second protrusion are spaced apart from each other in the radial direction, a locking groove is provided in the storage tube, the locking groove constitutes the locking portion, when the first protrusion and the second protrusion extend into the locking groove, the locking portion and the locked portion cooperate with each other, and when the first protrusion and the second protrusion withdraw from the locking groove, the cooperative relationship between the locking portion and the locked portion is released.

[0016] In some embodiments, the clip arm further includes a slide groove, the storage tube further includes a pin shaft, and the slide groove and the pin shaft are slidably connected.

[0017] In some embodiments, the storage tube is further provided with an unlocking portion that is abutted against the locked portion, and when the locked portion is subjected to an acting force by the unlocking portion, the cooperative relationship between the locked portion and the locking portion is released.

[0018] In some embodiments, the unlocking portion includes an elastic piece provided on the outer wall, the elastic piece and the protrusion are butted against each other, and when the elastic piece receives a force and deflects the protrusion radially toward the inside of the channel, the cooperative relationship between the locked portion and the locking portion is released.

[0019] In some embodiments, an open groove is provided in the outer wall, the open groove extending along the axial direction of the storage tube, the elastic piece includes a fixed end of the elastic piece and a free end of the elastic piece, the fixed end of the elastic piece is fixedly attached to the outer wall, the free end of the elastic piece is provided along the open groove, and the free end of the elastic piece is deflectable along a radial direction relative to the fixed end of the elastic piece.

[0020] In some embodiments, the free end of the elastic piece is provided with a butt portion that is bent and extends radially into the channel, and the butt portion is capable of deflecting radially within the locking groove or deflecting out of the locking groove.

[0021] In some embodiments, the storage tube includes a first storage tube and a second storage tube, a distal end of the second storage tube is fitted into a proximal end of the first storage tube, the unlocking portion is provided on the first storage tube, and the locking groove is provided on the second storage tube.

[0022] In some embodiments, the locking portion includes a pin shaft provided on the storage tube, the pin shaft penetrating the storage tube along the radial direction of the storage tube, the clip arm includes a slide groove, the slide groove and the pin shaft are slidably connected, and the locked portion includes an elastic stopper provided on the path of the slide groove.

[0023] In some embodiments, when the resilient stopper is deflected under a force, the cooperation between the locked portion and the locking portion is released.

[0024] In some embodiments, when the pin shaft is subjected to a force and compressed in a radial direction to be separated from the storage tube, the cooperation between the locking portion and the locked portion is released.

[0025] In some embodiments, the clip includes a pull rod and a link structure connected to a proximal end of the clip arm and the pull rod connected to the proximal end of the link structure, and when the pull rod moves the link structure from a distal end to a proximal end, the link structure closes the clip arms.

[0026] In some embodiments, the locked portion is provided at a proximal end of the link structure.

[0027] In some embodiments, when the connection between the locked portion and the clip arm is released, the restriction of movement of the clip by the storage tube is released.

[0028] In some embodiments, when the clip arm is distorted, broken or displaced under a force, the connection between the locked portion and the clip arm is released.

[0029] In some embodiments, the clip includes a connecting pin, and the first clip arm and the second clip arm are connected by the connecting pin, or a receiving space is formed by a proximal end of the first clip arm and a proximal end of the second clip arm, the connecting pin extends radially through the receiving space, and one end of the connecting pin constitutes the locked portion, or both ends of the connecting pin constitute the locked portion.

[0030] In some embodiments, a portion of the clip arm located on the proximal end side of the connection pin constitutes a first connection portion, and the clip and the locked portion form a connection relationship via the first connection portion, and when the first connection portion is subjected to a radial pressing force into the channel, the first connection portion distorts, breaks, or displaces, thereby releasing the connection relationship between the clip and the locked portion.

[0031] In some embodiments, when the restriction on movement of the locking portion relative to the outer wall is released, the restriction on movement of the clip by the storage tube is released.

[0032] In some embodiments, the storage tube includes a first storage tube and a second storage tube, the second storage tube is provided inside the first storage tube, the outer wall is provided on the first storage tube, and the locking portion is provided on the second storage tube, and when the clip is in the locked state, the first storage tube and the second storage tube are fixed relative to each other, and when the clip is switched from the locked state to the unlocked state, the first storage tube and the second storage tube are movable relative to each other.

[0033] In some embodiments, a hanging groove is provided on the first storage tube and a hanging portion is provided on the second storage tube, and when the hanging groove and the hanging portion are hooked together, the first storage tube and the second storage tube are fixed relative to each other, and when the hanging portion is disengaged from the hanging groove, the first storage tube and the second storage tube are able to move relative to each other.

[0034] In some embodiments, the second storage tube includes an elastic piece, the elastic piece including a first end and a second end, the first end of the elastic piece constituting the hanging portion, and the second end of the elastic piece extending into the interior of the channel of the second storage tube to constitute the locking portion.

[0035] In some embodiments, when the first end of the elastic piece is distorted, broken or displaced by a force, the hook portion is released from the hook groove.

[0036] In another aspect of the present specification, there is provided a clip device comprising: a clip device as described in any one of claims 1 to 31; and a delivery device connected to the clip device, wherein the delivery device is configured to be capable of delivering the clip device to a target area where a specified operation is to be performed, the delivery device includes an operating unit, the operating unit is capable of causing the clip device to perform the specified operation, and the delivery device is releasably connected to the clip device.

[0037] In some embodiments, the clip device includes a clip, the clip having a locked state and an unlocked state, the clip device further including a removal device for switching the clip from the locked state to the unlocked state.

[0038] In yet another aspect of the present specification, there is provided a method for unlocking a clip in a clip device, the clip device including a clip and a storage tube, the clip including a locked portion, the storage tube including a locking portion, the locking portion and the locked portion working together to lock the clip and keep clip arms of the clip closed, the method including operating a removal device to apply a removal force to the clip in a locked state, and applying the removal force to the locked portion to release the cooperative relationship between the locking portion and the locked portion so that the clip can be switched from the locked state to an unlocked state, or applying the removal force to the locking portion to release the cooperative relationship between the locking portion and the locked portion so that the clip can be switched from the locked state to an unlocked state. a removal force acting on a clip arm of the clip to release the cooperative relationship between the locking portion and the locked portion so that the clip can be switched from the locked state to an unlocked state, or a removal force acting on the clip arm of the clip to release the connected relationship between the clip arm and the locked portion so that the clip can be switched from the locked state to an unlocked state, or a removal force acting on the storage tube to move the locking portion to a distal end relative to an outer wall of the storage tube so that the clip can be switched from the locked state to an unlocked state, wherein the distal end of the clip arm opens when the clip is in the unlocked state. [Brief description of the drawings]

[0039] The present application will be further illustrated by exemplary embodiments, which are illustrated in detail in the drawings, which are not limiting, and in which like reference numerals indicate identical structures. [Figure 1] 1 is a schematic diagram of an overall view of a clip device shown in some embodiments of the present application. [Diagram 2] 1 is a schematic diagram of a clipping device as shown in some embodiments according to the present application. [Diagram 3] 1 is a cross-sectional view of a clip device according to some embodiments of the present disclosure. [Figure 4]1 is a cross-sectional view of a clip device according to some embodiments of the present disclosure. [Diagram 5] 1 is a schematic diagram of a clip as shown in some embodiments of the present application. [Figure 6] FIG. 6 is a side view of FIG. 5. [Figure 7] 1 is a schematic diagram of a clip as shown in some embodiments of the present application. [Figure 8] FIG. 8 is a side view of FIG. [Figure 9] FIG. 2 is a schematic diagram of a first storage tube as shown in some embodiments of the present application. [Figure 10] FIG. 2 is a schematic diagram of a second storage tube as shown in some embodiments of the present application. [Figure 11] FIG. 2 is a side view of a clip according to some embodiments of the present disclosure. [Figure 12] 1 is a schematic diagram of a clip according to some embodiments of the present disclosure in an unlocked state. [Figure 13] 1 is a schematic diagram of a clip in a locked state according to some embodiments of the present application. [Figure 14] 1 is a schematic diagram of a clip in a locked state according to some embodiments of the present application. [Figure 15] 1 is a schematic diagram of a clip according to some embodiments of the present disclosure in an unlocked state. [Figure 16] 1 is a schematic diagram of an operation procedure of a clipping device according to some embodiments of the present application. [Figure 17] FIG. 17 is an enlarged view of part A in FIG. [Figure 18] 2 is a schematic diagram showing the operation procedure of the clipping device according to some embodiments of the present application. [Figure 19] FIG. 19 is an enlarged view of part B in FIG. [Figure 20] 3 is a schematic diagram showing the operation procedure of the clipping device according to some embodiments of the present application. [Figure 21] FIG. 21 is an enlarged view of part C in FIG. 20. [Figure 22] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Diagram 23] FIG. 23 is an enlarged view of part D in FIG. 22. [Figure 24] 5 is a schematic diagram of the operation procedure of the clipping device shown in some embodiments of the present application. [Diagram 25] FIG. 25 is an enlarged view of part E in FIG. 24. [Figure 26] 1 is a schematic diagram of a clipping device as shown in some embodiments according to the present application. [Figure 27] 1 is a cross-sectional view of a clip device according to some embodiments of the present disclosure. [Figure 28] FIG. 28 is an enlarged view of part F in FIG. 27. [Figure 29] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Diagram 30] FIG. 30 is an enlarged view of part G in FIG. 29. [Diagram 31] 5 is a schematic diagram of the operation procedure of the clipping device shown in some embodiments of the present application. [Diagram 32] FIG. 32 is an enlarged view of part H in FIG. 31. [Diagram 33] 1 is a schematic diagram of a first clip arm according to some embodiments of the present application. [Diagram 34] 1 is a cross-sectional view of a storage tube according to some embodiments of the present disclosure. [Diagram 35] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Diagram 36] 5 is a schematic diagram of the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 37] 1 is a schematic diagram of a clipping device as shown in some embodiments according to the present application. [Figure 38] FIG. 2 is a schematic diagram of a storage tube as shown in some embodiments of the present application. [Figure 39] 1 is a cross-sectional view of a storage tube according to some embodiments of the present disclosure. [Diagram 40] 1 is a cross-sectional view of a storage tube according to some embodiments of the present disclosure. [Diagram 41] 1 is a schematic diagram of a clip as shown in some embodiments of the present application. [Diagram 42] FIG. 2 is a schematic diagram of a sheath as shown in some embodiments according to the present application. [Diagram 43] 1 is a schematic diagram of an operation procedure of a clipping device according to some embodiments of the present application. [Diagram 44] FIG. 47 is an enlarged view of part A in FIG. 46. [Diagram 45] 2 is a schematic diagram showing the operation procedure of the clipping device according to some embodiments of the present application. [Diagram 46] FIG. 46 is an enlarged view of part B in FIG. 45. [Figure 47] 3 is a schematic diagram showing the operation procedure of the clipping device according to some embodiments of the present application. [Figure 48] FIG. 48 is an enlarged view of part C in FIG. 47. [Figure 49] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 50] FIG. 50 is an enlarged view of part D in FIG. 49. [Figure 51] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 52] FIG. 52 is an enlarged view of part E in FIG. 51. [Figure 53] 1 is a schematic diagram of a first clip arm according to some embodiments of the present application. [Figure 54] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 55] 55 is a cross-sectional view taken along CC of the clip device 10 of FIG. 54. [Figure 56] 5 is a schematic diagram of the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 57] 57 is a DD cross-sectional view of the clip device 10 of FIG. 56. [Figure 58] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 59] FIG. 59 is an enlarged view of part I in FIG. 58. [Figure 60]5 is a schematic diagram of the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 61] FIG. 61 is an enlarged view of part J in FIG. 60. [Figure 62] FIG. 2 is a schematic diagram of a storage tube as shown in some embodiments of the present application. [Figure 63] 1 is a cross-sectional view of a storage tube according to some embodiments of the present disclosure. [Figure 64] FIG. 2 is a schematic diagram of a first storage tube as shown in some embodiments of the present application. [Figure 65] FIG. 2 is a schematic diagram of a second storage tube as shown in some embodiments of the present application. [Figure 66] FIG. 4 is a schematic diagram showing the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 67] FIG. 67 is an enlarged view of part K in FIG. 66. [Figure 68] 5 is a schematic diagram of the operation procedure of the clipping device shown in some embodiments of the present application. [Figure 69] FIG. 69 is an enlarged view of part L in FIG. 68. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0040] In order to more clearly describe the technical solutions according to the embodiments of the present application, the following briefly introduces the drawings necessary for describing the embodiments. Obviously, the drawings described below are merely some examples or embodiments of the present application, and those skilled in the art can apply the present application to other similar scenes based on these drawings without paying creative labor. Unless otherwise clear from the language environment or otherwise specified, the same symbols in the drawings represent the same structures or operations.

[0041] It should be understood that the terms "system", "apparatus", "unit" and / or "module" used herein are ways of distinguishing between different levels of components, elements, members, parts or assemblies, however, other terms may be used in place of the above terms if they achieve the same purpose.

[0042] As used herein and in the claims, unless the context clearly dictates otherwise, terms such as "a," "one," "an," and / or "the" do not specifically refer to the singular but may include the plural. In general, the terms "comprise" and "comprising" only imply the inclusion of explicitly identified steps and elements, and do not constitute an exclusive list of steps and elements, and a method or device may include other steps or elements.

[0043] In the present application, flow charts are used to describe the operations performed by the system according to the embodiments of the present application, but it should be understood that the preceding and subsequent operations are not necessarily performed in precise order, rather various steps may be processed in reverse order or simultaneously, other operations may be added to these steps, or one or more operations may be removed from these steps.

[0044] Examples herein relate to a clipping device, a clipping device for manipulating the clipping device, and an unlocking method for manipulating the clipping device to perform an unlocking operation. In some examples, an end effector may include a clipping device and a delivery device, the delivery device may be operable to deliver the clipping device to a location on a medical subject where a medical operation is to be performed, and the clipping device may be operable to perform a medical operation on the medical subject. In some examples, the medical operation performed by the clipping device may include surgical hemostasis, wound healing, tissue fixation, etc., and the clipping device may achieve these medical operations by closing the clip arms. In some examples, to maintain the medical operation performed by the clipping device, the clipping device may include a locking state, and when the clipping device is in the locked state, the clip arms of the clipping device may remain in a closed state. In some examples, the clipping device may remain in the locked state to be retained on the medical subject (e.g., clamped to tissue). In some examples, the clipping device may include a clip and a storage tube, and the clip may be stored in the storage tube and remain closed. A locking portion is provided on the storage tube and a locked portion is provided on the clip, and the cooperative relationship between the locking portion and the locked portion enables the storage tube to keep the clip closed by limiting the movement of the clip relative to the outer wall of the storage tube.

[0045] In some embodiments, when the medical procedure needs to be released, the clip device can be switched from a locked state to an unlocked state, so that the clip device can be reopened and moved away from the medical procedure without causing damage to the medical procedure. In some embodiments, the clip locking and unlocking procedures can be realized by releasing the restriction on the movement of the clip by the storage tube, such as by releasing the cooperation between the locking part and the locked part of the clip device, releasing the connection between the locked part and the clip arm, or releasing the restriction on the movement of the locking part relative to the outer wall.

[0046] Fig. 1 is an overall schematic diagram of a clip device shown in some embodiments according to the present application. As shown in Fig. 1, the clip device 1 may include a clip device 10 (including a clip 400 and a storage tube 500) and a delivery device 20 (including an operating section 100 and a delivery section 130) releasably connected to the clip device 10. The releasable connection is a connection method in which the connection relationship between the clip device 10 and the delivery device 20 can be removed and released.

[0047] The delivery device 20 is configured to deliver the clip device 10 to a target area where a specified operation is to be performed. In some embodiments, the target area may be an area (e.g., a lesion) in a target object where a specified operation needs to be performed. In some embodiments, the specified operation may be a medical operation performed during a surgical procedure, such as hemostasis, ligation, etc. In some embodiments, the target object may be an object undergoing a medical operation. In some embodiments, the target object may include a living object or a non-living object, where the living object may include a human (e.g., a patient), an animal, or a plant, etc., and the non-living object may include an experimental model (e.g., an organ model, etc.). In some embodiments, the delivery device 20 may also be used to manipulate the clip device 10 to perform a specified operation in the target area. In some embodiments, the delivery device 20 may include a manipulation unit 100 and a delivery unit 130. In some embodiments, the delivery unit 130 is usable to deliver the clip device 10 to a target area in the target object. In some embodiments, the manipulation unit 100 is capable of causing the clip device 10 to perform a specified operation. In some embodiments, the area in the target object where a specified operation needs to be performed may be a lesion area of ​​a human or animal. In some embodiments, the operating part 100 of the delivery device 20 may include an operating handle 110 and a slider 120, and specifically, an operator (e.g., a doctor) can operate the handle 110 and the slider 120 to perform an operation such as hemostasis or ligation using the clip device 10. In some embodiments, the delivery part 130 of the delivery device 20 may include a sheath 200 and a mandrel 210. In some embodiments, the sheath 200 may be a tubular structure that provides an internal channel for other members (e.g., the mandrel 210). In some embodiments, the mandrel 210 may be a long-shaft structure provided in the internal channel of the sheath for moving the clip device 10. In some embodiments, the delivery device 20 may be connected to the clip device 10 via the sheath 200 and the mandrel 210. For more details regarding the connection relationship between the delivery device 20 and the clip device 10, please refer to the description of FIG. 3 in this specification.

[0048] The clip device 10 may include a clip 400 and a storage tube 500, where the proximal end of the clip 400 is stored in a channel of the storage tube 500, and the distal end of the clip is used to perform a designated operation (e.g., hemostasis, ligation). The "proximal end" and "distal end" according to the embodiments of the present specification can indicate orientations, and refer to an orientation along the length of the clip device 1 (e.g., the extension direction of the delivery device 20) or an orientation along the direction in which the clip device 1 enters the human body, where the orientation located on the side close to the operator and away from the target object is the "proximal end", and the orientation located on the side close to the target object and away from the operator is the "distal end", and the "proximal end" and "distal end" should not be understood as indicating only ends.

[0049] 2, in some embodiments, the clip may include clip arms, the clip arms may include a first clip arm 410 and a second clip arm 420, and a distal end of the first clip arm 410 and a distal end of the second clip arm 420 are used for ligation. The storage tube 500 may include a tubular structure, the tubular structure may include an outer wall and a channel surrounded by the outer wall, and a proximal end of the first clip arm 410 and a proximal end of the second clip arm 420 are retractable into the channel of the storage tube 500. In some embodiments, as the clip moves proximally relative to the storage tube, the distal ends of the first clip arm 410 and the second clip arm 420 approach each other, and the first clip arm 410 and the second clip arm 420 gradually retract into the channel of the storage tube 500, closing the clip. In some embodiments, as the clip moves distally relative to the storage tube, the first clip arm 410 and the second clip arm 420 move out of the storage tube 500, the distal ends of the first clip arm 410 and the second clip arm 420 move away from each other, and the clip opens. For more details regarding the structure of the clip device 10, please see elsewhere herein.

[0050] In some embodiments, as shown in FIGS. 3-8, to realize the connection between the delivery device 20 and the clip device 10, the clip 400 may include a fitting hole 432, and the mandrel 210 may be fitted into the fitting hole 432 so as to complete the connection with the clip 400. Specifically, the mandrel 210 may include a large diameter portion 212 and a small diameter portion 213, and the diameter of the large diameter portion 212 of the mandrel 210 is larger than the inner diameter of the fitting hole 432, and the diameter of the small diameter portion 213 is smaller than the inner diameter of the fitting hole 432. In some embodiments, the small diameter portion 213 is fixed to the distal end of the mandrel 210, and the large diameter portion 212 is fixed to the small diameter portion 213. In some embodiments, the distal end of mandrel 210 is fixedly attached to connecting tip 211, the distal end of connecting tip 211 is fixedly attached to smaller diameter section 213, and the distal end of smaller diameter section 213 is fixedly attached to larger diameter section 212. In some embodiments, larger diameter section 212 and smaller diameter section 213 of mandrel 210 may be integrally formed or larger diameter section 212 of mandrel 210 may be fixedly attached to smaller diameter section 213 by means of gluing, clamping, welding, or the like.

[0051] In some embodiments, the distal end of the sheath 200 may include a position restricting recess 202, and the proximal end of the storage tube 500 is further provided with a position restricting protrusion 520, which cooperates with the position restricting recess 202 at the distal end of the sheath 200 to complete the connection and release between the sheath 200 and the storage tube 500. As shown in FIG. 3, in some embodiments, the distal end of the mandrel 210 may include a connection tip 211, and when the distal end of the mandrel 210 extends into the storage tube 500, the position restricting protrusion 520 can be subjected to the pressing force of the connection tip 211 against the position restricting recess 202 due to the elasticity of the position restricting protrusion 520, and as a result, the position restricting protrusion 520 is pressed by the connection tip 211 to extend into the position restricting recess 202. Here, the outer diameter of the connection tip 211 may be larger than the inner diameter of the position restriction protrusion 520, and the inner diameter of the position restriction protrusion 520 may be the inner diameter of the second storage tube 502. When the distal end of the mandrel 210 exits the storage tube, the position restriction protrusion 520 is no longer pressed by the connection tip 211, and the position restriction protrusion 520 elastically deforms to recover and then exits the position restriction recess 202. In some embodiments, the distal end of the mandrel 210 may not include the connection tip 211, and the outer diameter of the mandrel 210 may be larger than the inner diameter of the position restriction protrusion 520, and the mandrel 210 may extend into the position restriction protrusion 520 and then directly press the position restriction protrusion 520 to cause the position restriction protrusion 520 to extend into the position restriction recess 202.

[0052] In some embodiments, after the delivery device 20 is connected to the clip device 10, the mandrel 210 can move the clip 400 relative to the storage tube 500. In some embodiments, as the mandrel 210 moves proximally, the mandrel 210 moves the clip 400 proximally relative to the storage tube 500, and the clip 400 closes. In some embodiments, after the clip 400 closes, the clip 400 can be further locked to restrict the clip 400 from moving distally relative to the outer wall of the storage tube 500, so that the clip 400 remains closed and the clip 400 is in a locked state. That is, the locked state may be a state in which the clip 400 is closed and the clip 400 is restricted from moving relative to the outer wall of the storage tube 500. In some embodiments, a position in which the clip 400 is in the locked state may be defined as the first position. In some embodiments, the clip 400 may include a locked portion, and the storage tube 500 may include a locking portion. In some embodiments, the locking portion is restricted from moving distally relative to the outer wall of the encasing tube. In some embodiments, the locking portion may be connected (e.g., fixedly or removably connected) to the outer wall of the encasing tube 500 such that the locking portion is restricted from moving distally relative to the outer wall of the encasing tube 500. The cooperation between the locking portion and the locked portion can form a restriction on the movement of the clip 400 by the encasing tube 500, thereby realizing the locking of the clip 400. In some embodiments, the restriction on the movement of the clip 400 by the encasing tube 500 refers to the encasing tube 500 being able to restrict the tendency of the clip 400 to move distally relative to the outer wall of the encasing tube 500. In some embodiments, by locking the clip 400, the clip 400 can continuously clamp the human tissue to perform the functions of hemostasis and ligation.

[0053] In some embodiments, the locked state of the clip 400 can be released, and after the locked state is released, the clip 400 can move toward the distal end relative to the outer wall of the storage tube 500, and the clip 400 can open again, at which time the clip 400 is switched from the locked state to the unlocked state. That is, the unlocked state may be a state in which the restriction on the movement of the clip 400 relative to the outer wall of the storage tube 500 is released, and the clip 400 can open. In some embodiments, the position in which the clip 400 is located when the clip 400 is switched from the locked state to the unlocked state may be defined as the second position. In some embodiments, the restriction on the movement of the clip 400 relative to the outer wall of the storage tube 500 may be a restriction that the clip 400 cannot move toward the distal end relative to the outer wall of the storage tube 500. In some embodiments, after the clip 400 is switched from the locked state to the unlocked state, the clip 400 can release the clamped human tissue to achieve separation between the clip device 10 and the human tissue.

[0054] In some embodiments, the clip device 1 may further include a removal device 700 for switching the clip 400 from a locked state to an unlocked state. In some embodiments, the removal device 700 may be a clamp, a biopsy forceps, a snare, an energy device, or a special removal device capable of providing a removal function, and the removal device 700 may approach the clip device 10 through an endoscope forceps channel, and apply a force to an associated member of the clip device 10 (including, but not limited to, a locked portion, a locking portion, a first connecting portion connecting the clip and the locked portion, or a second connecting portion connecting the storage tube 500 and the locking portion), so that the associated member is distorted, broken, or displaced by the force, and finally the unlocking operation is completed. In some embodiments, the force application manner in which the removal device 700 applies a force to the target member may include applying a pressure radially inward, contacting the target member radially inward and then applying a force in the axial direction, or applying a force in the axial direction. For more details on the unlocking operation of the clipping device 10 by the removal device 700, please refer to the descriptions elsewhere in this specification.

[0055] In some embodiments, as shown in FIG. 4 and FIG. 5, the proximal end of the first clip arm 410 is provided with a first bent portion 411 that is bent toward the second clip arm 420, and the first bent portion 411 is provided with a first hole 412, and the proximal end of the second clip arm 420 is provided with a second bent portion 421 that is bent toward the first clip arm 410, and the second bent portion 421 is provided with a second hole 422. In some embodiments, the bend angle between the first bent portion 411 and the first clip arm 410 is 85° to 95°, and the bend angle between the second bent portion 421 and the second clip arm 420 is 85° to 95°. In some embodiments, the sum of the bend angles of the first bent portion 411 and the second bent portion 421 is 180°. In some embodiments, the first hole 412 and the second hole 422 are at least partially overlapped and communicated with each other, and the overlapped and communicated portion of the first hole 412 and the second hole 422 constitutes a fitting hole 432. Here, "at least a part" overlapping includes partially overlapping and communicating, and completely overlapping and communicating, where partially overlapping and communicating means that the first hole 412 and the second hole 422 are slightly shifted and do not completely overlap, and completely overlapping and communicating means that the first hole 412 completely overlaps within the range of the second hole 422, or the second hole 422 completely overlaps within the range of the first hole 412. In this case, overlapping can be understood as two holes communicating with each other. After the first hole 412 and the second hole 422 communicate with each other, the communicating part between the first hole 412 and the second hole 422 constitutes the fitting hole 432. In some embodiments, the fitting hole 432 may be a hole having a fitting space configured in another manner.

[0056] In some embodiments, the first clip arm 410 and the second clip arm 420 are elastic, and when no force is applied, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are spaced apart from each other, and the clip 400 is in an expanded (or open) state. In some embodiments, as the clip moves proximally relative to the storage tube, the first clip arm 410 and the second clip arm 420 are gradually stored within the channel of the storage tube 500, and the positional constraint of the channel of the storage tube 500 brings the distal ends of the first clip arm 410 and the second clip arm 420 closer to each other, and the clip is closed. In some embodiments, as the clip moves distally relative to the storage tube, the first clip arm 410 and the second clip arm 420 exit the storage tube 500, the first clip arm 410 and the second clip arm 420 are no longer subject to the positional constraints imposed by the storage tube 500, and the distal ends of the first clip arm 410 and the second clip arm 420 move away from each other under the action of elastic force, thereby opening the clip.

[0057] 4 and 5, in some embodiments, the clip 400 may further include a connecting pin 601, and the first clip arm 410 and the second clip arm 420 are pinned together via the connecting pin 601. In some embodiments, one end of the connecting pin 601 constitutes a locked portion 602. In some embodiments, both ends of the connecting pin 601 constitute the locked portion 602.

[0058] 4 and 5, in some embodiments, the axial direction of the connection pin 601 may be set parallel to the direction in which the first clip arm 410 and the second clip arm 420 move away from each other (i.e., the opening direction of the clip arms). In some embodiments, the first clip arm 410 and the second clip arm 420 have pinning holes, and the connection pin 601 is pinned to the first clip arm 410 and the second clip arm 420 through the pinning holes. In some embodiments, both ends of the connection pin 601 that pass through the first clip arm 410 and the second clip arm 420 and face the storage tube 500 constitute locked portions. In some embodiments, the clip 400 further includes an elastic ring 402, which is fitted around the connecting pin 601, and is located between the first clip arm 410 and the second clip arm 420, and when the first clip arm 410 and the second clip arm 420 are closed, the elastic ring 402 is compressed by the first clip arm 410 and the second clip arm 420, and the elastic ring 402 provides an elastic force, and the direction of the elastic force of the elastic ring 402 is a direction to move the first clip arm 410 and the second clip arm 420 away from each other at the position where the elastic ring 402 is abutted against each other. Preferably, the elastic ring 402 is a coil spring, and the coil spring is fitted around the connecting pin 601 through its coil.

[0059] In some embodiments, referring to Fig. 7 and Fig. 8, the axial direction of the connection pin 601 may be set perpendicular to the direction in which the first clip arm 410 and the second clip arm 420 move away from each other (i.e., the opening direction of the clip arms). As shown in Fig. 7 and Fig. 8, in some embodiments, the clip 400 includes a connection pin 601, and an accommodation space is formed by the proximal ends of the first clip arm 410 and the second clip arm 420, and the connection pin 601 extends radially through the accommodation space, and the connection pin 601 is connected to the first clip arm 410 and the second clip arm 420 via a pin fixing portion 603. In some embodiments, one end of the connection pin 601 constitutes a locked portion 602. In some embodiments, both ends of the connection pin 601 constitute the locked portion 602.

[0060] In some embodiments, the first clip arm 410 and the second clip arm 420 may not have elasticity, and the first clip arm 410 and the second clip arm 420 may be provided with a guide structure to open and close the first clip arm 410 and the second clip arm 420. In some embodiments, the guide structure may include, but is not limited to, a slide groove or a link structure.

[0061] In some embodiments, the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 are provided with slide grooves, and the storage tube 500 includes a pin shaft, and the pin shaft is fixed to the storage tube 500. In some embodiments, the pin shaft is provided in the slide groove, and the slide groove is slidable relative to the pin shaft. In some embodiments, the slide groove at the proximal end of the first clip arm 410 may be a first slide groove, and the slide groove at the proximal end of the second clip arm 420 may be a second slide groove. In some embodiments, the extension direction of the first slide groove and the second slide groove may be non-parallel to the axial direction of the storage tube. In some embodiments, the slide grooves of the first clip arm 410 and the second clip arm 420 are provided symmetrically with respect to the axial line of the storage tube 500. In some embodiments, the pin shaft may be provided along the diameter direction of the storage tube 500, and the pin shaft passes through the first slide groove and the second slide groove. In some embodiments, when the clip 400 moves along the axial direction of the storage tube 400 relative to the outer wall of the storage tube 500, the first slide groove and the second slide groove slide relative to the pin shaft to open and close the clip arm. For more details on how the slide groove and the pin shaft cooperate to open and close the clip arm, please refer to the descriptions elsewhere in this specification.

[0062] In some embodiments, referring to Figs. 11 to 15, the clip 400 includes a link structure 605. In some embodiments, the link structure 605 may include a four-joint link structure, which includes a first distal end rod and a second distal end rod located at a distal end, and a first proximal end rod and a second proximal end rod located at a proximal end. In some embodiments, the first clip arm 410 and the second clip arm 420 are hinged, and a portion of the first clip arm 410 located at a proximal end of the hinge connection point constitutes a first distal end rod, and a portion of the second clip arm 420 located at a proximal end of the hinge connection point constitutes a second distal end rod. In some embodiments, a distal end of the first proximal end rod is hinged to the first clip arm, a distal end of the second proximal end rod is hinged to the second clip arm, and a proximal end of the first proximal end rod is hinged to a proximal end of the second proximal end rod. In some embodiments, each hinge point of the link structure may be connected via a connecting pin. In some embodiments, the clip 400 may further include a pull rod, the distal end of which is connected to the hinge point at the proximal end of the link structure 605. In some embodiments, the proximal end of the pull rod may be connected to the mandrel 210. In some embodiments, the link structure 605 closes the clip arms when the pull rod moves the link structure 605 from the distal end to the proximal end.

[0063] As shown in Figures 11 to 15, the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 are connected via a link structure 605, and when the pull rod 606 moves the link structure 605 from the distal end to the proximal end, the included angle between the first proximal end rod and the second proximal end rod becomes smaller, so that the included angle between the first clip arm and the second clip arm becomes smaller, and the first clip arm 410 and the second clip arm 420 are closed. As shown in Figure 12, the clip is in an open state, and at this time, the pull rod 606 is not moving to the proximal end. As shown in Figure 13, the pull rod 606 moves from the distal end to the proximal end, and at this time, the clip is in a closed state.

[0064] In some embodiments, the clip 400 may not include a pull rod, and a fitting hole for connecting with the mandrel 210 may be provided near the hinge connection point of the proximal end of the first proximal rod and the proximal end of the second proximal rod, and the fitting hole may be a hole opened in the connection pin of the hinge connection point. In some embodiments, the mandrel 210 may be directly connected to the proximal end of the link structure 605 through the fitting hole so that the mandrel 210 can move the link structure 605 from the distal end to the proximal end. In some embodiments, when the mandrel 210 moves the link structure 605 from the distal end to the proximal end, the included angle between the first proximal rod and the second proximal rod decreases, and the included angle between the first clip arm 410 and the second clip arm 420 decreases, so that the first clip arm 410 and the second clip arm 420 are gradually closed.

[0065] In some embodiments, referring to FIG. 9 and FIG. 10, the storage tube 500 may include a first storage tube 501 and a second storage tube 502, and the second storage tube 502 is at least partially fitted into the channel of the first storage tube 501, and the outer wall of the first storage tube 501 constitutes the outer wall of the storage tube 500. In some embodiments, the second storage tube 502 and the first storage tube 501 may be fabricated as two separate tubular structures and then assembled together, or the second storage tube 502 and the first storage tube 501 may each be fabricated from a single tubular structure. In some embodiments, the material of the first storage tube 501 may include, but is not limited to, stainless steel, titanium, tantalum, platinum, palladium, etc. In some embodiments, the material of the second storage tube 502 may include, but is not limited to, stainless steel, titanium, tantalum, platinum, palladium, etc. In some embodiments, the material of the first storage tube 501 may be the same as the material of the second storage tube 502. In some embodiments, the material of first containment tube 501 may be different than the material of second containment tube 502. For example, first containment tube 501 can be made of a high strength titanium metal material, while second containment tube 502 can be made of a high toughness stainless steel material.

[0066] As shown in FIG. 9 , in some embodiments, a blocking portion 513 is provided at the distal end of the storage tube 500, the blocking portion 513 extends into the channel of the storage tube 500, and the blocking portion 513 is located at the distal end of the connecting pin 601, so that the blocking portion 513 can prevent the clip 400 from escaping from the distal end of the storage tube 500.

[0067] 10 , in some embodiments, the storage tube 500 is provided with a rail groove 503 along the axial direction to facilitate movement of the clip 400 relative to the storage tube 500. In some embodiments, the rail groove 503 may be drilled in the second storage tube 502, for example, the rail groove 503 may be laser cut into the sidewall of the second storage tube 502. In some embodiments, the connecting pin 601 is slidable within the rail groove 503, the locked portion 602 is extendable within the rail groove 503, and the rail groove 503 can guide the locked portion 602 to a locking position in which the locking portion 511 cooperates with the locking portion 511.

[0068] In some embodiments, the clip 400 may include a locking portion and the storage tube 500 may include a locking portion to limit movement of the clip 400 relative to the storage tube 500 and allow the clip 400 to be locked. The locking portion may be a component on the storage tube 500 that cooperates with the locking portion to limit distal movement of the clip 400 relative to the storage tube 500. In some embodiments, the locking portion may be a structure or component on the storage tube 500, such as a resilient piece, a groove, a pin shaft, etc. The locking portion may be a structure or component on the clip 400 that cooperates with a structure or component such as a resilient piece, a groove, a pin shaft, etc. In some embodiments, the locking portion may be a structure or component such as a protrusion, a contact pin, a resilient stopper, etc.

[0069] In some embodiments, the locked portion and the locking portion may have a one-to-one corresponding cooperative relationship, for example, the locked portion is a protrusion provided on the clip 400, while the locking portion is an elastic piece provided on the storage tube 500; for example, the locked portion is a protrusion provided on the clip 400, while the locking portion is a groove provided on the storage tube 500; for example, the locked portion is a connection pin provided on the clip 400, while the locking portion is an elastic piece provided on the storage tube 500; For example, the locked portion is a connecting pin provided at the proximal end of the link structure 605, while the locking portion is a recessed groove provided in the storage tube 500; for example, the locked portion is an elastic stopper provided in a slide groove on the clip 400, while the locking portion is a pin shaft provided in the storage tube 500; for example, the locked portion is a connecting pin provided at the proximal end of the link structure 605, while the locking portion is an elastic piece provided in the storage tube 500; for example, the locked portion is a protrusion provided at the proximal end of the link structure 605, while the locking portion is an elastic piece provided at the proximal end of the link structure 605. When the locked portion and / or the locking portion are distorted, broken or displaced by force, the cooperation between the locked portion and the locking portion is released.

[0070] In some embodiments, because the locking portion is restricted from moving distally relative to the outer wall of the storage tube 500, when the locked portion and the locking portion cooperate, the clip is also restricted from moving distally relative to the outer wall of the storage tube 500, i.e., a restriction on the movement of the clip 400 by the storage tube 500 is formed, and the clip 400 is placed in a locked state.

[0071] In some embodiments, when the restriction on distal movement of clip 400 relative to the outer wall of storage tube 500 is removed, clip 400 is able to move distally relative to storage tube 500 and the clip arms are able to open again, i.e., clip 400 is switched from a locked state to an unlocked state, also referred to as clip 400 being switched from a first position to a second position.

[0072] In some embodiments, when the cooperation between the locking portion and the locked portion is released, the movement of the clip 400 is no longer restricted by the storage tube 500, and the clip 400 is switched from the locked state to the unlocked state. In some embodiments, when the locked portion and / or the locking portion is distorted, broken, or displaced under force, the cooperation between the locked portion and the locking portion is released.

[0073] In some embodiments, when the connection between the locked portion and the clip arm is released, the restriction on movement of the clip 400 by the storage tube 500 is released and the clip 400 switches from a locked state to an unlocked state. In some embodiments, when the connection between the locked portion and the clip arm is released, the clip 400 transitions from a first position (the distal end of the first clip arm and the distal end of the second clip arm remain closed) to a second position (the distal end of the first clip arm and the distal end of the second clip arm open again). The connection method between the locked part and the clip arm is compatible with various connection and release methods, for example, the locked part is a protrusion provided on the clip arm, and the connection method between the locked part and the clip arm is integrally molded, and when the protrusion is broken, the connection relationship between the locked part and the clip arm is released, for example, the locked part is a connection pin provided on the clip 400, the first clip arm 410 and the second clip arm 420 are connected via the connection pin 601, and when distortion occurs in the first connection part where the first clip arm 410 and / or the second clip arm 420 abuts against the connection pin 601, the connection relationship between the locked part and the clip arm is released, For example, the locking portion is a connecting pin 601 provided on the clip arm, and an accommodating space is formed by the proximal ends of the first clip arm 410 and the second clip arm 420, and the connecting pin 601 extends radially through the accommodating space, and when a displacement occurs in the first connecting portion where the connecting pin 601 engages with the first clip arm 410 and the second clip arm 420, the connection between the locked portion and the clip arm is released, and for example, the locked portion is a stopper provided in a slide groove in the clip arm, and the stopper is fixedly attached to the slide groove in the clip arm, and when the stopper is broken, the connection between the locked portion and the clip arm is released.

[0074] In some embodiments, when the restriction on movement of the locking portion relative to the outer wall is released, the restriction on movement of the clip 400 by the storage tube 500 is released, and the clip 400 is switched from the locked state to an unlocked state. In some embodiments, when the connection relationship between the locking portion and another position on the storage tube 500 is released, the restriction on the movement of the locking portion relative to the outer wall is released and the clip moves from the first position (the distal end of the first clip arm and the distal end of the second clip arm remain closed) to the second position (the distal end of the first clip arm and the distal end of the second clip arm open again), and the connection method between the locking portion and the storage tube is compatible with various connection and release methods, for example, the locking portion is an elastic piece, and the second storage tube 502 provided with the elastic piece and the first storage tube 501 are connected via a hooking portion and a hooking groove, and when the hooking relationship between the hooking portion and the hooking groove is released, the connection relationship between the locking portion and the storage tube 500 is released, and for example, the locking portion is a pin shaft on the storage tube 500, and when radial contraction occurs in the pin shaft and the connection relationship between the pin shaft and the storage tube 500 is released, the connection relationship between the locking portion and the storage tube is released.

[0075] The operation procedure of the clip device 10 will be described with reference to Figs. 16 to 25. The operation procedure of the clip device 10 includes, but is not limited to, the following steps, and the order of some steps therein can be adjusted according to actual circumstances, and some steps can be repeated. Here, "the clip is in a locked state" and "the clip is in an unlocked state" are used merely for convenience of explanation, and do not indicate that the initial state of the clip is a "locked state", nor that the final state of the clip is an "unlocked state", but are used only to indicate that the unlocking method transitions the clip from a "locked state" to an "unlocked state", and when the clip is in a locked state, the distal end of the first clip arm and the distal end of the second clip arm remain closed, and when the clip is in an unlocked state, the distal end of the first clip arm and the distal end of the second clip arm open again.

[0076] In some embodiments, when the locking portion is distorted, broken, or displaced under a force, the cooperation between the locking portion and the locked portion is released. In some embodiments, the force applied to the locking portion may be applied by a removal device 700. As shown in FIGS. 16-25, in some embodiments, the clip 400 is in an unlocked state and the locking portion 511 is distorted, broken, or displaced radially outward.

[0077] 16 and 17, in some embodiments, the clip device 10 may include a position restricting protrusion 520, and the delivery device 20 may include a position restricting recess 202, and the position restricting protrusion 520 may be a component for cooperating with the position restricting recess 202 to restrict the movement of the clip device 10. In some embodiments, the clip 400 is in an open state, and the position restricting protrusion 520 of the clip device 10 and the position restricting recess 202 of the delivery device 20 cooperate with each other to realize an outer connection, and the fitting hole 432 of the clip device 10 and the large diameter portion 212 of the connection tip 211 cooperate with each other to realize an inner connection. The movement of the mandrel 210 from the proximal end to the distal end moves the clip 400 from the proximal end to the distal end, so that the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are separated from each other, and the first clip arm 410 and the second clip arm 420 are proximate to the tissue 300.

[0078] In some embodiments, the locking portion 511 includes an elastic piece 510, and the elastic piece 510 may be provided on the outer wall of the storage tube 500. In some embodiments, the elastic piece 510 includes a first end 510A, a second end 510B, and a third end 510C, and the first end 510A of the elastic piece is fixed to the first storage tube 501, the second end 510B of the elastic piece is provided at a proximal end of the first end 510A of the elastic piece, and the third end 510C of the elastic piece is provided at a distal end of the first end 510A of the elastic piece, and the second end 510B of the elastic piece constitutes a locking portion. In some embodiments, the number of the elastic pieces 510 may include two, and the two elastic pieces 510 may be provided symmetrically along the circumference of the outer wall of the storage tube 500.

[0079] In some embodiments, the locked portion 602 may include a connection pin 601. In some embodiments, referring to FIGS. 4 to 7, the clip 400 includes a first clip arm 410, a second clip arm 420, and a connection pin 601, the first clip arm and the second clip arm are connected via the connection pin 601, and both ends of the connection pin 601 constitute the locked portion 602. In some embodiments, referring to FIGS. 11 to 15, the clip 400 includes a first clip arm 410, a second clip arm 420, and a link structure 605, and a hinge connection point at the proximal end and / or the hinge connection point at the distal end of the link structure 605 includes a connection pin. In some embodiments, the connection pin at the hinge connection point provided at the proximal end of the link structure 605 (i.e., the hinge connection point between the proximal end of the first proximal end rod and the proximal end of the second proximal end rod) may constitute the locked portion 602. In some embodiments, a connecting pin at a hinge connection point (i.e., a hinge connection point between a first clip arm and a second clip arm) at a distal end of the link structure 605 may constitute the locked portion 602. In some embodiments, the clip 400 further includes a pull rod connected to the link structure 605, and the pull rod and a proximal end of the link structure 605 may be connected via a connecting pin, and the connecting pin may constitute the locked portion 602.

[0080] 18 and 19, in some embodiments, the clip 400 is in a closed state, and the position restricting protrusion 520 of the clip device 10 and the position restricting recess 202 of the delivery device 20 cooperate with each other to realize an outer connection, and the fitting hole 432 of the clip device 10 and the large diameter portion 212 of the connection tip 211 cooperate with each other to realize an inner connection. In the operation of the clip 400 moving from the open state to the closed state, the mandrel 210 moves from the distal end to the proximal end, and the clip 400 moves from the distal end to the proximal end, so that the distal end of the first clip arm 410 and the distal end of the second clip arm 420 approach each other, and the distal end of the first clip arm 410 and the distal end of the second clip arm 420 clamp the tissue 300. The connecting pin 601 moves from the distal end to the proximal end in the channel of the storage tube 500, and both ends of the connecting pin 601 (i.e., the locked portion 602) are not yet located at the proximal end of the second elastic piece end 510B (locking portion 511), that is, the locked portion 602 and the locking portion 511 have not yet cooperated with each other, that is, the clip 400 is only closed but not locked. At this time, if the clamping position of the tissue 300 clamped by the distal end of the first clip arm 410 and the distal end of the second clip arm 420 is inappropriate, the mandrel 210 may be pushed from the proximal end to the distal end to move the distal end of the first clip arm 410 and the distal end of the second clip arm 420 away from each other, that is, the clip 400 may be transitioned from the closed state to the reopened state.

[0081] In some embodiments, the first storage tube 501 includes an elastic piece 510, the elastic piece 510 includes a first end 510A, a second end 510B, and a third end 510C, the first end 510A of the elastic piece is fixed to the outer wall of the first storage tube 501, the second end 510B of the elastic piece is provided at the proximal end of the first end 510A of the elastic piece, the third end 510C of the elastic piece is provided at the distal end of the first end 510A of the elastic piece, and the second end 510B of the elastic piece constitutes a locking portion. In some embodiments, when the clip 400 is in a locked state, the second end 510B of the elastic piece extends into the channel, and the third end 510C of the elastic piece extends outside the outer wall, and when the clip 400 is switched from the locked state to the unlocked state, the second end 510B of the elastic piece extends outside the outer wall, and the third end 510C of the elastic piece extends into the channel. In some embodiments, the first clip arm 410 and the second clip arm 420 are connected via a connection pin 601, and both ends of the connection pin 601 constitute a locked portion 602. As shown in Figs. 20 to 21, in some embodiments, the clip 400 is in a locked state, and the connection between the clip device 10 and the delivery device 20 is released. In some embodiments, the release of the connection between the clip device 10 and the delivery device 20 may include the release of the outer connection between the position restricting protrusion 520 of the clip device 10 and the position restricting recess 202 of the delivery device 20. In some embodiments, the release of the connection between the clip device 10 and the delivery device 20 may further include the release of the inner connection between the fitting hole 432 of the clip device 10 and the large diameter portion 212 of the connection tip 211. When the clip 400 is in a locked state, the clip 400 is fixed to the tissue 300, and the delivery device 20 is withdrawn through the endoscope forceps channel.The operation of the clip 400 to transition from the closed state to the locked state is as follows: the clip 400 is moved from the distal end to the proximal end by the movement of the mandrel 210 from the distal end to the proximal end, the connection pin 601 is moved from the distal end to the proximal end within the channel of the storage tube 500, and both ends of the connection pin 601 (i.e., the locked portion 602) are positioned at the proximal end of the second end 510B of the elastic piece (locking portion 511) beyond the second end 510B of the elastic piece (locking portion 511), and the second end 510B of the elastic piece (locking portion 511) is positioned within the channel of the storage tube 500. Since the connecting pin 601 is blocked by the second end 510B (locking portion 511), the connecting pin 601 extends into the proximal end, the third end 510C of the elastic piece extends outside the channel of the storage tube 500, and the radial spacing of the second end 510B (locking portion 511) of the elastic piece becomes smaller than the radial spacing of the locked portion 602, the axial movement of the clip 400 from the proximal end to the distal end is prevented, i.e., the distal end of the first clip arm 410 and the distal end of the second clip arm 420 remain closed, i.e., the clip 400 is in a locked state. In other words, when the clip 400 is in a locked state, the second end of the elastic piece extends into the channel, the third end of the elastic piece extends outside the outer wall, both ends of the connection pin 601 (i.e., the locked portion 602) and the second end 510B of the elastic piece (locking portion 511) cooperate with each other, the movement of the clip 400 is restricted by the storage tube 500, and the distal ends of the first clip arm 410 and the second clip arm 420 remain closed.

[0082] 22-23, in some embodiments, the clip 400 is in a state waiting to be removed. The removal device 700 enters through the endoscope forceps channel. The first removal arm 701 and the second removal arm 702 of the removal device 700 are spread so as to be adjacent to the unlocking portion 512 of the clip 400, which is already in a locked state.

[0083] In some embodiments, after the clip 400 is in the locked state, it is possible to switch the clip 400 from the locked state to an unlocked state by releasing the cooperation between the locking portion 511 and the locked portion 602.

[0084] In some embodiments, when the locking portion 511 is distorted, broken, or displaced, the cooperation between the locking portion 511 and the locked portion 602 is released.

[0085] 24-25, in some embodiments, clip 400 is in a resumed state, i.e., clip 400 is in an unlocked state. In the operation of the clip transitioning from the locked state to the unlocked state, a radially inward force is applied to elastic piece third end 510C (unlocking portion 512) by first removal arm 701 and second removal arm 702, and elastic piece third end 510C transitions from a state in which it extends outside the channel of storage tube 500 to a state in which it extends inside the channel of storage tube 500, whereby elastic piece second end 510B is displaced radially outward, i.e., elastic piece second end 510B transitions from a state in which it extends inside the channel of storage tube 500 to a state in which it extends outside the channel of storage tube 500. That is, when the third end 510C of the elastic piece is subjected to a radial force acting on the inside of the storage tube, the third end 510C of the elastic piece extends into the inside of the channel of the storage tube 500, and the second end 510B (locking portion 511) of the elastic piece extends outside the outer wall of the channel of the storage tube 500, the distance between both ends of the connection pin 601 (i.e., the locked portion 602) becomes smaller than the distance between the second end 510B (locking portion 511), the cooperation between the second end 510B (locking portion 511) of the elastic piece and both ends of the connection pin 601 (i.e., the locked portion 602) is released, and the restriction on the movement of the clip 400 by the storage tube 500 is released. In some embodiments, the locked portions 602 are protrusions provided on the distal end of the first clip arm 410 and the proximal end of the second clip arm 420, and the distance between the locked portions 602 is the distance between the protrusions. When the clip 400 is in the unlocked state, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 move away from each other, that is, the clip 400 transitions from the closed state to the reopened state.

[0086] In some embodiments, when the locked portion 602 of the clip 400 is distorted, broken, or displaced, the cooperation between the locking portion 511 and the locked portion 602 is released.

[0087] In some embodiments, the locked portion 602 includes a connecting pin 601, which is connected to a clip arm, and when the connecting pin is compressed in the radial direction of the storage tube under a force, the cooperation between the locking portion 511 and the locked portion 602 is released. As shown in Figs. 26 to 27, in some embodiments, the locking portion 511 may include an elastic piece 510. In some embodiments, the elastic piece 510 includes a first elastic piece end 510A and a second elastic piece end 510B, where the first elastic piece end 510A is fixed to the storage tube 500 and the second elastic piece end 510B extends into the channel of the storage tube 500. In some embodiments, referring to FIG. 23 to FIG. 25, the elastic piece may include a first end 510A, a second end 510B, and a third end 510C, where the first end 510A is fixed to the first storage tube 501, the second end 510B is provided at a proximal end of the first end 510A, and the third end 510C is provided at a distal end of the first end 510A. In some embodiments, the second end 510B forms a locking portion 511. In some embodiments, the number of elastic pieces 510 may be two, and the two elastic pieces 510 may be symmetrically provided along the circumference of the outer wall of the storage tube 500. In some embodiments, the storage tube 500 may not include the elastic piece 510, and instead, a groove toward the distal end is provided on the outer wall of the storage tube 500, and the groove forms a locking portion. In some embodiments, the number of grooves may be two, and the two grooves may be symmetrically arranged along the circumference of the outer wall of the storage tube 500 .

[0088] In some embodiments, the clip 400 includes a connection pin 601, and the connection pin 601 can change its length along its axis by being distorted along its axis. In some embodiments, one end of the connection pin 601 constitutes a locked portion 602. In some embodiments, both ends of the connection pin 601 constitute the locked portion 602. In some embodiments, the connection pin 601 includes movable ends provided at both ends of the connection pin 601 and a spring 604 connected to the movable ends, and the movable ends compress the spring 604 along the axis of the connection pin 601 (or along the radial direction of the storage tube 500) when subjected to a force, thereby making the dimension of the connection pin 601 along the radial direction of the storage tube 500 smaller than the interval of the locking portion 511 (for example, the interval between the two elastic piece second ends 510B or the interval between the two recessed grooves). As shown in FIG. 28, the connection pin 601 includes a spring 604, and when the spring 604 receives a radially inward pressing force, the spring 604 contracts radially inward, reducing the radial spacing of the movable ends (locked portions 602) of the spring 604. When the radial spacing of the movable ends (locked portions 602) of the spring 604 becomes smaller than the spacing of the locking portions 511 (e.g., second ends 510B of the elastic pieces), the clip 400 transitions from a locked state to an unlocked state.

[0089] In some embodiments, as shown in FIGS. 29-32, clip 400 transitions from a locked state (clip 400 is locked and waiting to be removed) to an unlocked state (clip 400 is in a resumed state).

[0090] As shown in Figures 29-30, in some embodiments, the clip 400 is in a locked state, the outer connection between the position restricting protrusion 520 of the clip device 10 and the position restricting recess 202 of the delivery device 20 is released, the inner connection between the fitting hole 432 of the clip device 10 and the large diameter portion 212 of the connection tip 211 is released, the clip 400 is fixed to the tissue 300, and the delivery device 20 exits through the endoscope forceps channel. The operation of the clip 400 to transition from the closed state to the locked state is as follows: the clip 400 is moved from the distal end to the proximal end by the movement of the mandrel 210 from the distal end to the proximal end, the connection pin 601 is moved from the distal end to the proximal end within the channel of the storage tube 500, and both ends of the connection pin 601 (i.e., the locked portion 602) pass the second end 510B (locking portion 511) of the elastic piece and are positioned at the proximal end of the second end 510B (locking portion 511), and the second end 510B (locking portion 511) of the elastic piece is positioned at the proximal end of the second end 510B (locking portion 511). Since the connecting pin 601 extends into the channel of the storage tube 500 and the radial distance H of the elastic piece second end 510B (locking portion 511) becomes smaller than the radial distance D1 of the locked portion 602, the connecting pin 601 is blocked by the elastic piece second end 510B (locking portion 511), and the axial movement of the clip 400 from the proximal end to the distal end is prevented, that is, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are kept closed, that is, the clip 400 is in a locked state. That is, the clip 400 is in a locked state, and both ends of the connecting pin 601 (i.e., the locked portion 602) and the elastic piece second end 510B (locking portion 511) cooperate with each other, and the distal ends of the first clip arm 410 and the second clip arm 420 are kept closed. In some embodiments, when the clip 400 is moved from the distal end to the proximal end by movement of the mandrel 210 from the distal end to the proximal end, the contact pin 601 can be compressed within the channel of the storage tube 500, and at this time, the length of the contact pin 601 along the radial direction of the storage tube is less than its initial length along the radial direction of the storage tube when the contact pin 601 is not compressed.In some embodiments, when the contact pin 602 moves to the proximal end and passes the locking portion 511 (e.g., the second end 510B of the elastic piece or a groove on the outer wall of the storage tube), the compression of the contact pin by the storage tube is released, and the contact pin 601 recovers to its initial length. In some embodiments, the initial length of the contact pin 601 is greater than the radial spacing H of the locking portion 511, and the locking portion 511 can serve to block the contact pin 602 so that the axial movement of the clip 400 from the proximal end to the distal end is limited.

[0091] When it is necessary to remove the clip, the removal device 700 is advanced through the endoscope forceps channel, and the first detachment arm 701 and the second detachment arm 702 of the removal device 700 are spread adjacent to the unlocking portion 512 of the clip 400 that is already in the locked state.

[0092] 31-32, in some embodiments, clip 400 is in a resumed state, i.e., the clip is in an unlocked state. When a force is applied radially inward to locked portion 602 (e.g., the movable end of connection pin 601) by first detachment arm 701 and second detachment arm 702 via unlocking portion 512, spring 604 in contact with locked portion 602 receives a radially inward pressing force and contracts radially inward, i.e., the radial interval of locked portion 602 becomes smaller, and when radial interval D2 of locked portion 602 becomes smaller than interval H of locking portion 511, clip 400 transitions from the locked state to the unlocked state. In some embodiments, locking portion 511 is a lock groove provided in the storage tube. When the clip 400 is in the unlocked state, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 move away from each other, that is, the clip 400 transitions from the closed state to the reopened state.

[0093] In some embodiments, the clip arm includes a protrusion provided at a proximal end of the clip arm, which may be a component for cooperating with the locking groove to realize a locked state, and which may constitute a locked portion, and when the protrusion is subjected to a force and displaced along the radial direction of the storage tube, the cooperative relationship between the locking portion and the locked portion is released.

[0094] In some embodiments, the protrusion includes a first protrusion provided at a proximal end of the first clip arm 410 and a second protrusion provided at a proximal end of the second clip arm 420, the first protrusion and the second protrusion are spaced apart from each other along the radial direction, a lock groove is provided in the storage tube 500, the lock groove constitutes a locking portion 511, when the first protrusion and the second protrusion extend into the lock groove, the locking portion 511 and the locked portion 602 cooperate with each other, and when the first protrusion and the second protrusion retract from the lock groove, the cooperation between the locking portion 511 and the locked portion 602 is released. In some embodiments, the clip 400 further includes a slide groove, the slide groove is provided at a proximal end of the clip arm, the storage tube 500 further includes a pin shaft, and the slide groove and the pin shaft are slidably connected.

[0095] As shown in Figs. 33 to 36, in some embodiments, a slide groove 440 is provided at the proximal end of the clip arm, and the storage tube 500 includes a pin shaft 550, and the pin shaft 550 is fixed to the storage tube 500. In some embodiments, the pin shaft 550 is provided to pass through the slide groove 440, and the extension direction of the slide groove 440 is non-parallel to the axial direction of the storage tube. In some embodiments, the slide groove (e.g., the first slide groove) of the first clip arm 410 and the slide groove (e.g., the second slide groove) of the second clip arm 420 are provided symmetrically with respect to the axial line of the storage tube, and when the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 receive an axial pulling force from the distal end to the proximal end, the slide groove 440 moves from the distal end to the proximal end with respect to the pin shaft 550, and the distal end of the first clip arm 410 and the distal end of the second clip arm 420 gradually approach each other.

[0096] As shown in Figs. 35 and 36, in some embodiments, a lock groove 560 is provided in the storage tube 500, and the lock groove 560 constitutes a locking portion 511. In some embodiments, the lock groove 560 may be a concave groove, a notch, or a slit structure opened in the outer wall of the storage tube 500. In some embodiments, a first protrusion 461 and a second protrusion 462 are provided in the first clip arm 410 and the second clip arm 420, and the first protrusion 461 and the second protrusion 462 constitute a locked portion 602. As shown in Fig. 42, the lock groove 560 (locking portion 511) and the first protrusion 461 and the second protrusion 462 (locked portion 602) cooperate with each other, so that the movement of the clip 400 toward the distal end relative to the outer wall of the storage tube 500 is restricted by the storage tube 500, and the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are kept closed, that is, the clip 400 is in a locked state. As shown in FIG. 43, when the first protrusion 461 and the second protrusion 462 (locked portion 602) are subjected to a radially inward pressing force, the mutual cooperative relationship between the locking groove 560 (locking portion 511) and the first protrusion 461 and the second protrusion 462 (locked portion) is released, the restriction on the movement of the clip by the storage tube 500 is released, and the clip 400 is placed in an unlocked state, so that the distal end of the first clip arm 410 and the distal end of the second clip arm 420 can be separated from each other, i.e., the clip 400 transitions from the closed state to the reopened state.

[0097] In some embodiments, referring to Figures 37 to 42, the clip 400 includes a first clip arm 410, a second clip arm 420 and a connection pin 601, and the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 are provided with a first protrusion 461 and a second protrusion 462 having elasticity, respectively, the first protrusion 461 and the second protrusion 462 constituting a locked portion 602, the connection pin 601 passes through a connection hole 504 penetrating the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420, and the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 can be stored within a channel of the storage tube 500. In some embodiments, as the clip 400 moves proximally against the outer wall of the storage tube 500, the first clip arm 410 and the second clip arm 420 are pressed against each other by the outer wall of the storage tube, allowing the distal ends of the first clip arm 410 and the second clip arm 420 to move toward each other, closing the clip 400. In some embodiments, as the clip 400 moves distally against the outer wall of the storage tube 500, the outer wall of the storage tube gradually releases pressure on the first clip arm 410 and the second clip arm 420, allowing the distal ends of the first clip arm 410 and the second clip arm 420 to move away from each other, allowing the clip 400 to open again.

[0098] In some embodiments, the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 are releasably connected to a connecting piece 214 provided in the delivery device 20, and the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420, which tend to move away from each other, approach each other by the pressure of the connecting piece 214. In some embodiments, as shown in Figures 42 to 44, the delivery device 20 includes a sheath 200 and a mandrel 210 provided in a channel of the sheath 200, and a connecting piece 214 is fixed to a distal end of the mandrel 210. In some embodiments, the number of connecting pieces 214 is two. In some embodiments, two connection pieces 214 are releasably connected to the connection pin 601, and the two connection pieces 214 press the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 respectively radially inward, so that the first protrusion 461 and the second protrusion 462 remain close to each other, and when the connection piece 214 is subjected to sufficient pulling force, the connection piece 214 deforms or breaks and separates from the connection pin 601, and the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 rebound radially outward due to elastic recovery action. In some embodiments, an end cover 201 is further fixed to the distal end of the sheath 200, and a position control recess 202 is provided in the end cover 201. The proximal end of the storage tube 500 is stored in the position control recess 202, thereby removably connecting the sheath 200 and the storage tube 500.

[0099] In some embodiments, a locking groove 560 is provided in the tube wall at the proximal end of the storage tube 500, and the locking groove 560 constitutes a locking portion 511. When the clip 400 is connected to the connecting piece 214, the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 are kept close to each other by the connecting piece 214, as shown in Figures 44 and 46. When the clip 400 and the connecting piece 214 are released from each other, the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 expand radially outward and are hooked into the locking groove 560, and the clip is placed in a locked state, as shown in Figure 48.

[0100] In some embodiments, the storage tube 500 is integrally molded, and as shown in FIG. 46, the locking grooves 560 are directly drilled into the storage tube 500 by finishing, thereby reducing the assembly of parts and stabilizing performance.

[0101] In some embodiments, the storage tube 500 includes a first storage tube 501 and a second storage tube 502, as shown in FIG. 44, and the distal end of the second storage tube 502 is fitted into the channel at the proximal end of the first storage tube 501. The hole on the wall of the second storage tube 502 and the hole on the first storage tube 501 are both assembled as the lock groove 560. The hooking dimension of the lock groove 560 in the actual product is small (generally less than 0.5 mm). If multiple functional structures (e.g. elastic pieces, lock grooves) are simultaneously provided on the storage tube 500 with an axial dimension of less than 10 mm and a diameter of less than 1 mm, the yield of a single storage tube 500 will be low and the cost will be high. Therefore, the elastic piece 510 is provided on the wall of the first storage tube 501, and the first storage tube 501 and the second storage tube 502 are each provided with holes before being assembled to form the lock groove 560, thereby reducing the difficulty of processing a single part and reducing the cost.

[0102] In some embodiments, when the first protrusion 461 and the second protrusion 462 (locked portion) are subjected to a radially inward pressing force, the mutual cooperative relationship between the locking groove 560 (locking portion) and the first protrusion 461 and the second protrusion 462 (locked portion) is released, the restriction on the movement of the clip by the storage tube is released, and the clip 400 is placed in an unlocked state, so that the distal end of the first clip arm 410 and the distal end of the second clip arm 420 can be separated from each other, i.e., the clip 400 transitions from a closed state to an open state.

[0103] In some embodiments, the storage tube 500 is further provided with an unlocking portion 512 that is abutted against the locked portion 602, and when the locked portion 602 receives an acting force from the unlocking portion 512, the cooperative relationship between the locked portion 602 and the locking portion 511 is released. The unlocking portion 512 may be a component that can release the cooperative relationship between the locked portion 602 and the locking portion 511 by applying an external force to the locking portion 511 or the locked portion 602.

[0104] In some embodiments, the unlocking portion 512 includes an elastic piece 510 provided on the outer wall of the storage tube 500, and the elastic piece 510 and the first protrusion 461 and the second protrusion 462 are butted against each other. When the elastic piece 510 receives a force and deflects the first protrusion 461 and the second protrusion 462 radially toward the inside of the channel, the cooperative relationship between the locked portion 602 and the locking portion 511 is released. In some embodiments, at least two grooves 570 are formed in the outer wall of storage pipe 500 along the axial extension direction of the channel of storage pipe 500, a portion of the wall of storage pipe 500 constitutes elastic piece 510, a portion of the elastic piece fixedly or integrally connected to storage pipe 500 is elastic piece fixed end 571, a portion of the elastic piece that can be deflected radially relative to elastic piece fixed end 571 along the channel of storage pipe 500 is elastic piece free end 572, and the region of the elastic piece between elastic piece fixed end 571 and elastic piece free end 572 constitutes unlocking portion 512, i.e., unlocking portion 512 is provided on the wall of storage pipe 500. 48, the elastic piece free end 572 is provided with a butt portion 573 that extends radially inward along the channel of the storage tube 500, and the butt portion 573 can be deflected radially within the lock groove 560 or deflected out of the lock groove 560. The butt portion 573 may be a component for abutting against the protrusions (first protrusion 461 and second protrusion 462) of the clip arm, and can transmit the force along the radial direction toward the channel received by the elastic piece free end 572 to the protrusions of the clip arm. In some embodiments, the storage tube 500 includes a first storage tube 501 and a second storage tube 502, the distal end of the second storage tube 502 is fitted into the channel at the proximal end of the first storage tube 501, the unlocking portion 512 is provided in the first storage tube 501, and the lock groove 560 is provided in the second storage tube 502.

[0105] In some embodiments, as shown in Figures 43 to 44, the clip 400 is in an open state, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are spaced apart from each other, the clip 400 is connected to the connecting piece 214, the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 are held close to each other radially inward by the connecting piece 214, the elastic piece 510 provided on the storage tube 500 is in a state in which it is not receiving any force, and a part or the entirety of the butt portion 573 at the free end 572 of the elastic piece, which extends and bends radially inward along the channel of the storage tube 500, extends into the lock groove 560 (lock portion 511) of the storage tube 500, and the butt portion 573 is not butted against the first protrusion 461 and the second protrusion 462 (locked portion 602).

[0106] In some embodiments, as shown in FIGS. 45-46 , the clip is in a closed and unlocked state, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are proximate to each other, and tissue 300 is contained between the distal end of the first clip arm 410 and the distal end of the second clip arm 420, the clip 400 is still connected to the connecting piece 214, and the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 are held radially inwardly proximate to each other by the connecting piece 214, at this time. If it is necessary to adjust the clamping angle or position, the mandrel 210 can be pushed from the distal end to the proximal end to reopen the first clip arm 410 and the second clip arm 420, and the elastic piece 510 provided on the storage tube 500 is in a state where it is not subjected to force, and a part or all of the butt portion 573 at the free end 572 of the elastic piece, which extends and bends radially inward along the channel of the storage tube 500, extends into the lock groove 560 (lock portion 511) of the storage tube 500, and the butt portion 573 is not butted against the protrusion (locked portion 602).

[0107] In some embodiments, as shown in FIGS. 47-48 , the clip 400 is in a locked state, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are closed to each other while clamping the tissue 300, the connecting piece 214 is continuously subjected to a pulling force from the distal end to the proximal end, so that the connecting piece 214 is deformed or broken, and the connecting piece 214 and the clip 400 are separated (the delivery device 20 and the clip device 10 are released), and the first protrusion 461 and the second protrusion 462 of the first clip arm 410 and the second clip arm 420 are closed to each other. (locked portion 602) rebounds radially outward and enters locking groove 560 (locking portion 511) of storage tube 500, first protrusion 461 and second protrusion 462 (locked portion 602) and locking groove 560 (locking portion 511) cooperate with each other, first protrusion 461 and second protrusion 462 (locked portion 602) and butt portion 573 butt against each other, butt portion 573 deflects radially outward, and lock release portion 512 deflects radially outward in the axial direction relative to storage tube 500, so that lock release portion 512 is positioned outside locking groove 560 (locking portion 511).

[0108] In some embodiments, as shown in Figures 49-50, after the clip 400 is closed and locked, the first clip arm 410 and the second clip arm 420 need to be opened again, i.e., the cooperation between the first protrusion 461 and the second protrusion 462 (locked portion 602) and the lock groove 560 (locking portion 511) needs to be released (removed). The removal device 700 can apply a removal force to the clip device 10, and the removal device 700 can be a biopsy forceps, a snare, an energy device, or a special removal instrument, etc., and the removal device 700 can apply a removal force to the locked portion 602 in proximity to the clip device 10 through an endoscope forceps channel. In some embodiments of the present specification, the axial distance of the unlocking portion 512 (elastic piece 510) is 2mm to 10mm, and the removal force of the removal device 700 is applied to the unlocking portion 512 (elastic piece 510) located on the wall of the storage tube 500, so that the area of ​​action of the removal force of the removal device 700 is increased, and in addition, when the clip 400 is in the locked state, the unlocking portion 512 is deflected radially outward relative to the storage tube 500 in the axial direction, i.e., a part of the unlocking portion 512 protrudes from the surface of the storage tube 500, so that the removal device 700 (particularly, a snare) is more suitable for hooking the unlocking portion 512 (elastic piece 510) and applying the removal force radially outward. Therefore, according to the present invention, the difficulty of removal is reduced and the success rate of removal is improved.

[0109] In some embodiments, as shown in Figures 51 and 52, the clip 400 is in an unlocked state, and the cooperative relationship between the first protrusion 461 and the second protrusion 462 (locked portion 602) and the locking groove 560 (locking portion 511) is released. When removal device 700 (e.g., a snare) hooks unlocking portion 512 (elastic piece 510) on the wall of storage tube 500 and applies a removal force radially inward, unlocking portion 512 (elastic piece 510) is deflected radially inward and abutting portion 573 of unlocking portion 512 (elastic piece 510) enters lock groove 560 (locking portion 511). In other words, unlocking portion 512 (elastic piece 510) is deflected radially inward into lock groove 560 (locking portion 511), and first protrusion 461 and second protrusion 462 (locked portion 602) that are abutted against abutting portion 573 are abutted against each other. ) is subjected to a radially inward force, so that first protrusion 461 and second protrusion 462 (locked portion 602) are deflected radially inward, and first protrusion 461 and second protrusion 462 (locked portion 602) escape from lock groove 560 (locking portion 511). The cooperative relationship between first protrusion 461 and second protrusion 462 (locked portion 602) and lock groove 560 (locking portion 511) is released, and the distal ends of first clip arm 410 and second clip arm 420 open again due to the elastic action of the clip arms themselves, and clip device 10 placed at the lesion is separated from tissue 300.

[0110] In some embodiments, the locking portion includes a pin shaft provided on the storage tube, the pin shaft being fixed relatively to an outer wall of the storage tube, the clip arm includes a slide groove, the pin shaft passing through the inside of the slide groove and being slidably connected to the slide groove, and the locked portion includes an elastic stopper provided on the path of the slide groove.

[0111] As shown in Figures 53 to 57, in some embodiments, a slide groove 440 is provided at the proximal end of the clip arm, and the storage tube 500 includes a pin shaft 550 and a connecting hole 504, and the pin shaft 550 passes through the storage tube 500 along the radial direction of the storage tube 500 through the connecting hole 504, and when the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 are subjected to an axial pulling force from the distal end to the proximal end, the slide groove 440 moves around the pin shaft 550 from the distal end to the proximal end, and the position of the pin shaft 550 within the slide groove 440 moves from the proximal end of the slide groove 440 to the distal end of the slide groove 440, and the distal end of the first clip arm 410 and the distal end of the second clip arm 420 gradually approach each other. In some embodiments, the slide groove 440 is provided with an elastic stopper 450, which may be a component that provides a blocking effect on the movement path of the pin shaft 550.

[0112] In some embodiments, the pin shaft 550 constitutes a locking portion, and the elastic stopper 450 constitutes a locked portion. In some embodiments, the clip 400 is in an open state, and the clip arm moves the elastic stopper 450 to the pin shaft 550 under the action of a pulling force, and when the elastic stopper 450 moves to a position where the pin shaft 550 is located, it is located at the proximal end of the pin shaft 550 beyond the pin shaft 550 under the action of a pulling force. In some embodiments, when the elastic stopper 450 passes the pin shaft 550, the pin shaft 550 prevents the elastic stopper 450 from moving from the proximal end of the pin shaft 550 to the distal end of the pin shaft 550, so that the pin shaft 550 and the elastic stopper 450 form a cooperative relationship, the clip 400 is in a locked state, and the distal ends of the first clip arm 410 and the second clip arm 420 remain closed.

[0113] In some embodiments, when the resilient stopper 450 is deflected under a force, the cooperation between the locked portion 602 and the locking portion 511 is released.

[0114] In some embodiments, referring to Figures 56 and 57, the clip 400 is in an unlocked state, and the removal device 700 and the elastic stopper 450 (locked portion) are coupled to pull the elastic stopper 450 in the axial direction, whereby the elastic stopper 450 (locked portion 602) is displaced or deflected in the axial direction, and the cooperative relationship between the pin shaft 550 (locking portion 511) and the elastic stopper 450 (locked portion 602) is released, resulting in the clip arm being movable toward the distal end relative to the pin shaft 550, and the distal end of the first clip arm 410 and the distal end of the second clip arm 420 moving away from each other, i.e., the clip 400 transitions from the locked state to the unlocked state.

[0115] In some embodiments, when the pin shaft 550 is subjected to a force and compressed in the radial direction, and is released from the storage tube 500, the cooperation between the locking portion 511 and the locked portion 602 is released.

[0116] As shown in Figures 56 and 57, in some embodiments, the clip 400 is in an unlocked state, and a spring is provided in a pin shaft 550 provided in the storage tube 500. When the spring contracts radially due to the action of a radially inward pressing force, the pin shaft 550 falls out of the connection hole 504, i.e., the pin shaft 550 comes off the storage tube 500, and the pin shaft 550 no longer interferes with the movement of the elastic stopper 450, so that the connection between the pin shaft 550 (locking portion 511) and the storage tube 500 is released and the clip 400 is in an unlocked state. As a result, the distal end of the first clip arm 410 and the distal end of the second clip arm 420 can be separated from each other, i.e., the clip 400 can be opened again.

[0117] In some embodiments, when the connection between the locked portion 602 and the clip arm is released, the restriction of movement of the clip 400 by the storage tube 500 is released.

[0118] In some embodiments, as shown in FIGS. 58-61, the clip 400 transitions from a locked state (the clip 400 is in a locked state and waiting to be removed) to an unlocked state (the clip 400 is in a resumed state). In some embodiments, the clip 400 includes a first clip arm 410, a second clip arm 420, and a connection pin 601. In some embodiments, the first clip arm 410 and the second clip arm 420 are connected via the connection pin 601, and one or both ends of the connection pin 601 constitute a locked portion 602. In some embodiments, a receiving space is formed by the proximal ends of the first clip arm 410 and the second clip arm 420, the connection pin 601 extends radially through the receiving space, the connection pin 601 is connected to the first clip arm 410 and the second clip arm 420 via a pin fixing portion 603, and one or both ends of the connection pin 601 constitute the locked portion 602. In some embodiments, the storage tube includes an elastic piece, the elastic piece including a first end 510A of the elastic piece and a second end 510B of the elastic piece extending inside the channel of the storage tube 500, and the second end 510B of the elastic piece forming a locking portion 511.

[0119] 58 and 59, in some embodiments, the clip 400 is in a locked state and waiting to be removed, the clip 400 is in a locked state, the locking portion 511 and the locked portion 602 are locked together, and the distal ends of the first clip arm 410 and the second clip arm 420 remain closed. The removal device 700 is advanced through the endoscope forceps channel. The first removal arm 701 and the second removal arm 702 of the removal device 700 are spread adjacent to the unlocking portion 512 of the clip 400, which is already in the locked state.

[0120] In some embodiments, when the clip arm is distorted, broken, or displaced under force, the connection between the locked portion 602 and the clip arm is released.

[0121] In some embodiments, the first clip arm 410 has an end adjacent to the connection pin 601 with a first bent portion 411 bent toward the second clip arm 420, and the end of the first bent portion 411 that abuts against the connection pin 601 outside the body is a first coupling portion 411A, and the second clip arm 420 has an end adjacent to the connection pin 601 with a second bent portion 421 bent toward the first clip arm 410, and the end of the second bent portion 421 that abuts against the connection pin 601 is a second coupling portion 421A. In some embodiments, the first coupling portion 411A and the second coupling portion 421A constitute a first coupling portion, and the clip 400 and the locked portion 602 form a coupling relationship via the first coupling portion. In some embodiments, the first coupling portion 411A or the second coupling portion 421A constitutes a first coupling portion, and the clip 400 and the locked portion 602 form a coupling relationship via the first coupling portion. In some embodiments, the first connecting portion may be a structure that constitutes a connecting hole 504 on the clip arm. In some embodiments, the first connecting portion may be a structure that constitutes a pin fixing portion 603 on the clip arm.

[0122] In some embodiments, when the first connecting portion is subjected to radial pressure into the channel, the first connecting portion distorts, breaks, or displaces, causing the connection between the clip and the locked portion to be released. When the first detachment arm 701 and the second detachment arm 702 apply a force radially inward to the first connection portion (the first coupling portion 411A and / or the second coupling portion 421A) via the unlocking portion 512, the first coupling portion 411A and / or the second coupling portion 421A are deformed when they receive a radially inward pressing force, and the connection relationship between the proximal end of the clip 400 and the locked portion 602 is released, and the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 move from the proximal end to the distal end relative to the connecting pin 601, and the clip 400 is in an unlocked state, so that the distal end of the first clip arm 410 and the distal end of the second clip arm 420 are separated from each other, that is, the clip 400 transitions from the locked state to the unlocked state, and the clip 400 can be opened again. In some embodiments, the release of the connection relationship also includes breaking or displacement. In some embodiments, the first connecting portion may be a structure constituting a connecting hole 504 on the clip arm, and when the first connecting portion is broken by a force, the connecting hole 504 is destroyed and the connection relationship between the proximal end of the clip 400 and the connecting pin 601 (i.e., the locked portion 602) is released. In some embodiments, the first connecting portion may be a structure constituting a pin fixing portion 603 on the clip arm, and when the first connecting portion is displaced, broken, or distorted by a force, the pin fixing portion 603 can no longer fix the connecting pin, and the connection relationship between the proximal end of the clip 400 and the locked portion 602 is released.

[0123] In some embodiments, when the movement restriction of the locking portion 511 relative to the outer wall is released, the movement restriction of the clip 400 by the storage tube 500 is released.

[0124] In some embodiments, referring to Figures 62 to 65, storage tube 500 includes a first storage tube 501 and a second storage tube 502, second storage tube 502 is provided inside first storage tube 501, an outer wall is provided on first storage tube 501, and locking portion 511 is provided on second storage tube 502, and when clip 400 is in a locked state, first storage tube 501 and second storage tube 502 are fixed relative to each other, and when clip 400 is switched from the locked state to an unlocked state, first storage tube 501 and second storage tube 502 become movable relative to each other, thereby releasing the movement restriction of locking portion 511 relative to the outer wall.

[0125] In some embodiments, as shown in Fig. 62 to Fig. 65, a hooking groove 530 is provided in the first storage pipe 501, and a hooking portion 540 is provided in the second storage pipe 502. In some embodiments, the hooking groove 530 and the hooking portion 540 form a second connection portion, and the storage pipe 500 and the lock portion 511 form a connection relationship via the second connection portion. In some embodiments, when the hooking groove 530 and the hooking portion 540 hook with each other, the first storage pipe 501 and the second storage pipe 502 are fixed relative to each other, and when the hooking portion 540 is released from the hooking groove 530, the first storage pipe 501 and the second storage pipe 502 become movable relative to each other.

[0126] In some embodiments, the second storage tube 502 includes an elastic piece 510, which includes a first end 510A of the elastic piece provided at the distal end and a second end 510B of the elastic piece provided at the proximal end, the first end 510A of the elastic piece cooperating with the second hanging groove 532 to form the hanging portion 540, and the second end 510B of the elastic piece extending into the inside of the channel of the second storage tube 502 to form the locking portion 511.

[0127] In some embodiments, the hook groove 530 includes a first hook groove 531 and a second hook groove 532, and the hook portion 540 includes a first hook portion 541 and a second hook portion 542. In some embodiments, the first hook portion 541 and the second hook portion 542 are an elastic piece first end 510A and an elastic piece second end 510B that are engaged and connected to the first hook groove 531 and the second hook groove 532, respectively.

[0128] In some embodiments, when the first end 510A of the elastic piece is distorted, broken, or displaced due to a force, the hook portion 540 is released from the hook groove 530.

[0129] As shown in Figs. 66 to 67, in some embodiments, the clip 400 is in a locked state, the first hooking portion 541 of the second storage tube 502 is hooked into the first hooking groove 531 of the first storage tube 501, the second hooking portion 542 of the second storage tube 502 is hooked into the second hooking groove 532 of the first storage tube 501, the first storage tube 501 and the second storage tube 502 are connected, and the locked portion 602 and the locking portion 511 cooperate with each other, and the distal ends of the first clip arm 410 and the second clip arm 420 remain closed. In some embodiments, the locked portion 602 may be a connecting pin (for example, the connecting pin 601 connecting the first clip arm 410 and the second clip arm 420, or a connecting pin provided at the hinge connection point of the link structure 605). In some embodiments, the locked portion 602 may be a protrusion provided at the proximal end of the clip arm. The removal device 700 is advanced through the endoscope forceps channel. The first detachment arm 701 and the second detachment arm 702 of the removal device 700 are spread adjacent to the second connection portion of the clip 400, which is already in a locked state.

[0130] As shown in Fig. 68 and Fig. 69, in some embodiments, when clip 400 is in an unlocked state and first hooking portion 541 and second hooking portion 542 are subjected to a radially inward pressing force, the elastic pieces constituting the hooking portion are deformed. In some embodiments, when first hooking portion 541 is subjected to a radially inward pressing force, the engagement and connection relationship between first hooking portion 541 and first hooking groove 531 of first storage tube 501 is released, and the movement restriction of locking portion 511 relative to the outer wall of storage tube 500 is released. In some embodiments, when first hooking portion 541 and second hooking portion 542 are subjected to a radially inward pressing force, the engagement and connection relationship between first hooking portion 541 and second hooking portion 542 and first hooking groove 531 of first storage tube 501 and second hooking groove 532 of first storage tube 501 are released, and the movement restriction of locking portion 511 relative to the outer wall of storage tube 500 is released. In some embodiments, when the movement restriction of the locking portion 511 relative to the outer wall of the storage tube 500 is released, the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 can move from the proximal end to the distal end relative to the storage tube 500, and the clip 400 is in an unlocked state, allowing the distal end of the first clip arm 410 and the distal end of the second clip arm 420 to move away from each other, i.e., the clip 400 can be opened again. In some embodiments, the release of the connection relationship can also include breaking or displacement.

[0131] A method for unlocking a clip is further provided herein, which is applicable to the clip device 10 in any embodiment herein. In some embodiments, the method for unlocking a clip includes applying a removal force to a clip in a locked state, and applying the removal force to a locked portion to release the cooperation between the locking portion and the locked portion, so that the clip can be switched from the locked state to the unlocked state, or applying the removal force to a locking portion to release the cooperation between the locking portion and the locked portion, so that the clip can be switched from the locked state to the unlocked state, or applying the removal force to a clip arm of the clip to release the connection between the clip arm and the locked portion, so that the clip can be switched from the locked state to the unlocked state, or applying the removal force to a storage tube to move the locking portion toward a distal end relative to an outer wall of the storage tube, so that the clip can be switched from the locked state to the unlocked state, and a distal end of the clip arm opens when the clip is in the unlocked state.

[0132] In some embodiments, after the clip is closed and locked (the clip is in the first position), the removal device can unlock the clip and reopen the clip arms (e.g., first clip arm 410 and second clip arm 420) of the clip device. In some embodiments, the removal device 700 can travel through the endoscope forceps channel to the clip device and apply a removal force to the clip device. In some embodiments, the removal device 700 can include, but is not limited to, a biopsy forceps, a snare, an energy device, or other specialized removal device.

[0133] In some embodiments, the removal device 700 can apply a removal force to the locked portion, distorting, breaking or displacing the locked portion, thereby releasing the cooperation between the locking portion and the locked portion and switching the clip from a locked state to an unlocked state.

[0134] In some embodiments, the locked portion may be a connection pin 601 provided on the clip 400. In some embodiments, referring to FIG. 28, the clip 400 includes a connection pin 601, which can change its length along its axis by distorting along its axis, and one or both ends of the connection pin 601 constitute the locked portion 602. In some embodiments, the locking portion 511 may include an elastic piece, a recessed groove, or a locking groove 560 provided on the storage tube 500. The both ends of the connection pin 601 and the locking portion 511 cooperate with each other to bring the clip 400 into a locked state. In some embodiments, the connection pin 601 includes movable ends provided at both ends of the connection pin 601 and a spring 604 connected to the movable ends, and the movable ends receive a force to compress the spring 604 along the axial direction of the connection pin 601 (or along the radial direction of the storage tube 500), thereby making the dimension of the connection pin 601 along the radial direction of the storage tube 500 smaller than the distance between the locking portions 511 (e.g., the distance between the two elastic piece second ends 510B, or the distance between the two grooves). For more details on the structure of the connection pin 601, please refer to the descriptions elsewhere in this specification.

[0135] In some embodiments, the locked portion may be a protrusion provided on the clip 400. In some embodiments, as shown in Figs. 35-36, a lock groove 560 is provided on the storage tube 500, and the lock groove 560 constitutes the lock portion 511. In some embodiments, a first protrusion 461 and a second protrusion 462 are provided on the first clip arm 410 and the second clip arm 420, and the first protrusion 461 and the second protrusion 462 constitute the locked portion 602. As shown in Fig. 42, the lock groove 560 (lock portion 511) and the first protrusion 461 and the second protrusion 462 (locked portion 602) cooperate with each other, so that the movement of the clip 400 toward the distal end relative to the outer wall of the storage tube 500 is restricted by the storage tube 500, and the clip 400 is in a locked state. For more details on the structure of the protrusion, please refer to the description elsewhere in this specification.

[0136] In some embodiments, the locked portion 602 may include an elastic stopper 450, and the locking portion 511 may include a pin shaft 550 provided on the storage tube 500. The elastic stopper 450 and the pin shaft 550 cooperate with each other to bring the clip 400 into a locked state.

[0137] In some embodiments, the removal device can apply a removal force directly to the locked portion, distorting, breaking, or displacing the locked portion to release the cooperation between the locked and locking portions and switch the clip from a locked state to an unlocked state. The removal device can apply a removal force to the locked portion 602 via the endoscope forceps channel in proximity to the clip device.

[0138] In some embodiments, as shown in Figures 31 and 32, when a radially inward force is applied to locked portion 602 (e.g., the movable end of connecting pin 601) by first removal arm 701 and second removal arm 702 of removal device 700, and spring 604 abutting locked portion 602 receives a radially inward pressing force, it contracts radially inward, i.e., the radial spacing of locked portion 602 becomes smaller, and when radial spacing D2 of locked portion 602 becomes smaller than spacing H of locking portion 511, locked portion 602 disengages from locking portion 511, and clip 400 transitions to a locked state or an unlocked state.

[0139] In some embodiments, a radially inward removal force of the storage tube 500 is applied to the first protrusion 461 and the second protrusion 462 by the first removal arm 701 and the second removal arm 702 of the removal device 700, respectively, and when the first protrusion 461 and the second protrusion 462 (locked portion 602) are deflected by the pressing action of the radially inward removal force and disengage from the lock groove 560, the mutual cooperation relationship between the lock groove 560 (lock portion 511) and the first protrusion 461 and the second protrusion 462 (locked portion) is released, the restriction on the movement of the clip by the storage tube 500 is released, and the clip 400 is placed in an unlocked state.

[0140] In some embodiments, the removal device 700 can be coupled to the elastic stopper 450 and apply a removal force to the elastic stopper 450 to move the elastic stopper 450 along the axial direction of the storage tube 500, thereby releasing the cooperative relationship between the elastic stopper 450 and the pin shaft 550, releasing the restriction on the movement of the clip by the storage tube 500, and placing the clip 400 in an unlocked state.

[0141] In some embodiments, the clip device further includes an unlocking portion 512, and the removal device is capable of applying a removal force to the locked portion via the unlocking portion 512. In some embodiments, the unlocking portion 512 may be provided on the storage tube 500. In some embodiments, the storage tube 500 may include a first storage tube 501 and a second storage tube 502, and the unlocking portion 512 may be provided on the first storage tube 501.

[0142] In some embodiments, referring to Figures 49 and 50, the removal device 700 (e.g., a snare) can hook the unlocking portion 512 (e.g., the elastic piece 510) on the wall of the storage tube 500 and apply a removal force inward in the radial direction, whereby the unlocking portion 512 (elastic piece 510) is deflected inward in the radial direction, and the abutting portion 573 of the unlocking portion 512 (elastic piece 510) enters the lock groove 560 (lock portion 511), i.e., the unlocking portion 512 (elastic piece 510) is deflected inward in the radial direction until it reaches the lock groove 560 (lock portion 511). The locked portion 602, which is deflected and butts against the butting portion 573, receives a radially inward force, so that the locked portion 602 is deflected radially inward or compressed radially inward, and the locked portion 602 escapes from the locking groove 560 (locking portion 511), the cooperation between the locked portion 602 and the locking groove 560 (locking portion 511) is released, and the distal end of the first clip arm 410 and the distal end of the second clip arm 420 open again due to the elasticity of the clip arm itself, and the clip device placed at the lesion is separated from the tissue 300. In some embodiments, if the storage tube 500 does not have the unlocking portion 512, the axial distance of the locking groove 560 is generally 0.5 mm, and in order to unlock, the removal device 700 needs to be extended into the locking groove 560 to act on the locked portion 602, which is difficult to operate. In some embodiments, when storage tube 500 includes unlocking portion 512, the axial distance of unlocking portion 512 (elastic piece 510) is 2 mm to 10 mm, and the removal force of removal device 700 is applied to unlocking portion 512 (elastic piece 510) located on the wall of storage tube 500, thereby increasing the area over which the removal force of removal device 700 acts; and, when the clip is in the first position, unlocking portion 512 deflects radially outward in the axial direction relative to storage tube 500, i.e., a portion of unlocking portion 512 protrudes from the surface of storage tube 500, making it more suitable for removal device 700 (particularly, a snare) to hook unlocking portion 512 (elastic piece 510) and apply a removal force radially outward, thereby reducing the difficulty of removal and improving the success rate of removal.

[0143] In some embodiments, the removal device 700 can apply a removal force to the locking portion, distorting, breaking or displacing the locking portion, thereby releasing the cooperative relationship between the locking portion and the locked portion and switching the clip from a locked state to an unlocked state.

[0144] In some embodiments, referring to Figures 22 to 23, the locking portion may include an elastic piece 510 provided on the storage tube 500, and the elastic piece 510 may include a first elastic piece end 510A, a second elastic piece end 510B and a third elastic piece end 510C, and the second elastic piece end 510B located at the proximal end of the elastic piece 510 constitutes the locking portion 511.

[0145] In some embodiments, the first removal arm 701 and the second removal arm 702 of the removal device 700 are spread close to the clip 400 that is already in a locked state, and apply a removal force to the unlocking portion 512 (i.e., the third end 510C of the elastic piece located at the distal end of the elastic piece 510). Under the action of the removal force, a radially inward force is applied to elastic piece third end 510C (unlocking portion 512) by first removal arm 701 and second removal arm 702, and elastic piece third end 510C transitions from a state in which it extends outside the channel of storage tube 500 to a state in which it extends inside the channel of storage tube 500, causing elastic piece second end 510B to be displaced radially outward, i.e., elastic piece second end 510B transitions from a state in which it extends inside the channel of storage tube 500 to a state in which it extends outside the channel of storage tube 500, and as a result, the cooperative relationship between locking portion 511 and locked portion 602 is released, and clip 400 is placed in an unlocked state.

[0146] In some embodiments, the locked portion 602 may include an elastic stopper 450, and the locking portion 511 may include a pin shaft 550 provided on the storage tube 500. The elastic stopper 450 and the pin shaft 550 cooperate with each other to bring the clip 400 into a locked state. In some embodiments, the pin shaft 550 is connected to the storage tube 500 via the connection hole 504. In some embodiments, the pin shaft 550 is compressible along the radial direction of the storage tube 500.

[0147] In some embodiments, as shown in Figures 56 and 57, a spring is provided in pin shaft 550 provided in the storage tube, and the removal device is capable of applying a removal force to both ends of pin shaft 550. When pin shaft 550 is subjected to a radially inward pressing force and contracts radially, pin shaft 550 falls out of connection hole 504, i.e., pin shaft 550 comes out of storage tube 500, the connection between pin shaft 550 (locking portion) and storage tube 500 is released, pin shaft 550 no longer interferes with the movement of elastic stopper 450, and clip 400 is placed in an unlocked state.

[0148] In some embodiments, the removal device 700 can apply a removal force to the clip arm to distort, break, or displace the clip arm, thereby releasing the connection between the clip arm and the locked portion and switching the clip from a locked state to an unlocked state.

[0149] In some embodiments, the clip 400 and the locked portion 602 form a connection relationship via a first connecting portion (e.g., the first connecting portion 411A and / or the second connecting portion 421A). In some embodiments, the first connecting portion may be a structure that configures a connecting hole 504 on the clip arm. In some embodiments, the first connecting portion may be a structure that configures a pin fixing portion 603 on the clip arm. For more details on the first connecting portion, reference may be made to descriptions elsewhere in this specification.

[0150] In some embodiments, when the first connecting portion is subjected to a radial pressing force into the channel, the first connecting portion is distorted, broken, or displaced, and the connection relationship between the clip and the locked portion is released. A force is applied radially inward to the first connecting portion (the first connecting portion 411A and / or the second connecting portion 421A) via the unlocking portion 512 by the first detachment arm 701 and the second detachment arm 702 of the detachment device 700, and when the first connecting portion 411A and / or the second connecting portion 421A are subjected to a radially inward pressing force, they are deformed, and the connection relationship between the proximal end of the clip 400 and the locked portion 602 is released, and the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 move from the proximal end to the distal end relative to the connecting pin 601, and the clip 400 is in an unlocked state.

[0151] In some embodiments, the removal device 700 can apply a removal force to the storage tube to move the locking portion distally against the outer wall of the storage tube, switching the clip from a locked state to an unlocked state.

[0152] In some embodiments, the storage tube 500 includes a first storage tube 501 and a second storage tube 502 provided inside the first storage tube 501, and the locking portion 511 is provided on the second storage tube 502. In some embodiments, as shown in Fig. 66 to Fig. 67, in some embodiments, the clip 400 is in a locked state, the first hooking portion 541 of the second storage tube 502 is hooked on the first hooking groove 531 of the first storage tube 501, the second hooking portion 542 of the second storage tube 502 is hooked on the second hooking groove 532 of the first storage tube 501, the first storage tube 501 and the second storage tube 502 are connected, and the locked portion 602 and the locking portion 511 cooperate with each other, and the distal ends of the first clip arm 410 and the second clip arm 420 remain closed.

[0153] 68-69, first removal arm 701 and second removal arm 702 of removal device 700 can apply a removal force to first hanging portion 541 and second hanging portion 542, and when first hanging portion 541 and second hanging portion 542 receive a radially inward pressing force (i.e., a removal force), the elastic pieces constituting the hanging portions are deformed. In some embodiments, when first hanging portion 541 receives a radially inward pressing force, the engagement and connection relationship between first hanging portion 541 and first hanging groove 531 of first storage tube 501 is released, and the restriction on movement of locking portion 511 relative to the outer wall of storage tube 500 is released. In some embodiments, when the first hook portion 541 and the second hook portion 542 are respectively subjected to a radially inward pressing force, the engagement and connection relationship between the first hook portion 541 and the second hook portion 542 and the first hooking groove 531 of the first storage tube 501 and the second hooking groove 532 of the first storage tube 501 is released, respectively, thereby releasing the restriction on movement of the lock portion 511 relative to the outer wall of the storage tube 500. In some embodiments, when the restriction on movement of the lock portion 511 relative to the outer wall of the storage tube 500 is released, the proximal end of the first clip arm 410 and the proximal end of the second clip arm 420 become movable from the proximal end to the distal end relative to the storage tube 500, and the clip 400 is in an unlocked state.

[0154] In some embodiments, when the clip is switched from a locked state to an unlocked state, the distal ends of the clip arms of the clip are allowed to open.

[0155] According to the clip device, delivery device, and clip unlocking method of several embodiments of the present application, the clip can be unlocked and removed after it is closed and locked, thereby avoiding damage to the tissue clamped by the clip; by applying a removal force to a locked portion of a different structure by the removal device, the difficulty of removal can be reduced and the success rate of removal can be improved; and since the elastic piece and the storage tube can be fixedly connected, the structure of the clip is simplified and its production is facilitated.

[0156] Although the basic concept has been described above, it is obvious to those skilled in the art that the above detailed disclosure is merely presented as an example and does not limit the present application. Although not explicitly described in this specification, those skilled in the art can make various changes, improvements and modifications to the present application. These changes, improvements and modifications are intended to be suggested by the present application and are to be included within the spirit and scope of the exemplary embodiments of the present application.

[0157] Furthermore, certain terms are used herein to describe embodiments of the present application. For example, "one embodiment," "an embodiment," and / or "some embodiments" refer to a particular feature, structure, or characteristic associated with at least one embodiment of the present application. Thus, it is emphasized and understood that references to "one embodiment" or "one embodiment" or "one alternative embodiment" more than once in various parts of this specification do not necessarily all refer to the same embodiment. Also, certain features, structures, or characteristics of one or more embodiments of the present application may be combined as appropriate.

[0158] It should be noted that unless expressly stated in the claims, the order of enumeration of processing elements or sequences described herein, the use of alphanumeric characters, or the use of other designations does not limit the order of flows and methods of the present application. In the above disclosure, what are presently believed to be various useful embodiments of the invention have been described through various examples, but it will be understood that such details are for the sake of simplicity and that the appended claims are not limited to the disclosed embodiments, but on the contrary, are intended to cover all modifications and equivalent combinations within the spirit and scope of the embodiments of the present application. For example, the system components described above may be implemented by hardware devices, but may also be implemented as a software-only solution, for example, by installing the described system on an existing server or mobile device.

[0159] Similarly, in the foregoing description of embodiments of the present application, it will be understood that various features may be grouped together in a single embodiment, figure, or description for the purpose of simplifying the disclosure and facilitating an understanding of one or more embodiments of the invention. This method of disclosure, however, should not be interpreted as reflecting an intention that the claimed subject matter requires more features than are recited in each claim. Rather, claimed subject matter may include less than all features of a single foregoing disclosed embodiment.

[0160] In some embodiments, numbers describing the number of components and attributes are used, and the numbers describing such embodiments are understood to be modified in some embodiments by the modifiers "about," "approximately," or "substantially." Unless otherwise specified, "about," "approximately," or "substantially" indicate that the value described by the number is allowed to vary by ±20%. Thus, in some embodiments, all numerical parameters used in the specification and claims are approximations that may vary depending on the characteristics required for a particular embodiment. In some embodiments, the numerical parameters should be applied with the stated number of significant digits and ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters for determining the ranges in some embodiments of the present application are approximations, in certain embodiments, such numerical values ​​are set as precisely as possible.

[0161] All patents, patent applications, published patent applications, and other materials such as articles, books, specifications, publications, documents, etc. referenced in this application are incorporated herein by reference in their entirety, except for prosecution history documents that are inconsistent or inconsistent with the content of this application, and documents that may have a limiting effect on the broadest scope of the claims of this application (now or later related to this application). In addition, if the explanations, definitions, and / or use of terms in the accompanying documents of this application are inconsistent or inconsistent with the content set forth in this application, the explanations, definitions, and / or use of terms in this application shall control.

[0162] Finally, it should be understood that the embodiments described herein are merely illustrative of the principles of the embodiments of the present application. Other variations may be within the scope of the present application. As such, the embodiments of the present application are exemplary rather than limiting, and alternative configurations of the embodiments of the present application may be considered consistent with the teachings of the present application. Thus, the embodiments of the present application are not limited to the embodiments specifically introduced and described herein. [Explanation of symbols]

[0163] 1 Clip device, 10 Clip device, 20 Delivery device, 100 Operating portion, 110 Operating handle, 120 Sliding portion, 130 Delivery portion, 200 Sheath, 201 End cover, 202 Position regulating recess, 210 Mandrel, 211 Connection tip, 212 Large diameter portion, 213 Small diameter portion, 214 Connection piece, 300 Tissue, 400 Clip, 402 Elastic ring, 410 First clip arm, 411 First bending portion, 411A First connecting portion, 412 First hole, 420 Second clip arm, 421 Second bending portion, 421A Second connecting portion, 422 Second hole, 432 Fitting hole, 440 Slide groove, 450 Elastic stopper, 461 First protrusion, 462 Second protrusion, 500 Storage tube, 501 First storage tube, 502 Second storage tube, 503 rail groove, 504 connection hole, 505 positioning protrusion, 510 elastic piece, 510A elastic piece first end, 510B elastic piece second end, 510C elastic piece third end, 511 locking portion, 512 unlocking portion, 513 blocking portion, 520 position restricting protrusion, 530 hooking groove, 531 first hooking groove, 532 second hooking groove, 540 hooking portion, 541 first hooking portion, 542 second hooking portion, 550 pin shaft, 560 locking groove, 570 opening groove, 571 elastic piece fixed end, 572 elastic piece free end, 573 butting portion, 601 connection pin, 602 locked portion, 603 pin fixing portion, 604 spring, 606 pull rod, 605 link structure, 700 removal device, 701 First removal arm, 702 Second removal arm

Claims

1. a clip device comprising a clip and a storage tube, the clip comprising a clip arm, the clip arm comprising a first clip arm and a second clip arm, a distal end of the first clip arm and a distal end of the second clip arm adapted for ligation; the storage tube includes an outer wall and a channel surrounded by the outer wall, and a proximal end of the first clip arm and a proximal end of the second clip arm are receivable within the channel; the clip further includes a locking portion, the locking portion being connected to the clip arm, and the storage tube further includes a locking portion; When the locking portion is connected to the storage tube and the locking portion and the locked portion cooperate with each other, the storage tube restricts the movement of the clip toward the distal end of the first clip arm and the distal end of the second clip arm relative to the storage tube; and when the clip is in a locked state, the distal end of the first clip arm and the distal end of the second clip arm are closed, and a removal force is applied to the clip device by a preset means, the restriction of the movement of the clip by the storage tube is released, the clip is switched from a locked state to an unlocked state, and the distal end of the first clip arm and the distal end of the second clip arm can be opened again; The presetting means includes: or causing the locking portion to distort, break or shift until the removal force is applied to the locking portion to release the cooperation between the locking portion and the locked portion; or applying the removal force to the locking portion to cause the locking portion to distort, break, or displace until the locking portion and the storage tube are released from their cooperative relationship; Clip device.

2. The locked portion includes a connecting pin disposed inside the channel, and the locking portion includes an elastic piece, the elastic piece including a first end, a second end and a third end of the elastic piece, the first end of the elastic piece is connected to the outer wall of the storage tube, the second end of the elastic piece is provided at a proximal end of the first end of the elastic piece, the third end of the elastic piece is provided at a distal end of the first end of the elastic piece, and the second end of the elastic piece constitutes the locking portion, The clip device of claim 1, wherein when the clip is in the locked state, the second end of the elastic piece extends into the channel and cooperates with the connection pin, and the third end of the elastic piece extends outside the outer wall, and when the clip is switched from the locked state to the unlocked state, the second end of the elastic piece extends outside the outer wall, the cooperative relationship with the connection pin is released, the second end of the elastic piece extends outside the outer wall, and the third end of the elastic piece extends into the channel.

3. the locking portion includes a pin shaft provided on the storage tube, the pin shaft penetrating the storage tube along a radial direction of the storage tube, the clip arm includes a slide groove, the slide groove and the pin shaft are slidably connected, the locked portion includes an elastic stopper provided on a path of the slide groove, 2. The clip device according to claim 1, wherein when the pin shaft is subjected to a force and compressed in a radial direction to be separated from the storage tube, the cooperative relationship between the locking portion and the storage tube is released.

4. A clip device comprising: the clip device according to any one of claims 1 to 3; and a delivery device connected to the clip device, the delivery device being configured to be capable of delivering the clip device to a target area where a designated operation is to be performed; A clip device, wherein the delivery device includes an operating unit, the operating unit is capable of causing the clip device to perform the specified operation, and the delivery device is releasably connected to the clip device.

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