Antibacterial composition

Abstract

The present invention relates to an antibacterial composition comprising a compound represented by Chemical Formula 1, the antibacterial activity of which measured by Method 1 is 80% or more.

Description

[Technical field]

[0001] The present invention relates to antimicrobial compositions.

[0002] CROSS-REFERENCE TO RELATED APPLICATIONS This specification claims the benefit of the filing date of Korean Patent Application No. 10-2021-0141414 filed with the Korean Intellectual Property Office on October 21, 2021, and Korean Patent Application No. 10-2022-0118143 filed with the Korean Intellectual Property Office on September 19, 2022, the entire contents of which are incorporated herein by reference. [Background technology]

[0003] In recent years, there has been a demand for high antibacterial properties in a variety of products, including household goods and hygiene products.

[0004] The required level of antibacterial properties and the requirements for materials to provide antibacterial properties vary depending on the material of the product for which antibacterial properties are required and the final state of use. For example, the nature of the material to provide antibacterial properties and the level of antibacterial properties vary depending on the amount of antibacterial material applied to the product and the materials used together.

[0005] Therefore, it is necessary to develop antibacterial materials suitable for application to various products. Summary of the Invention [Problem to be solved by the invention]

[0006] An object of one embodiment of the present invention is to provide an antibacterial composition that has hydrophilic and hydrophobic properties and is advantageous in imparting antibacterial properties. [Means for solving the problem]

[0007] One embodiment of the present invention provides an antibacterial composition comprising a compound represented by the following chemical formula 1, and having an antibacterial activity of 80% or more against at least one strain of gram-positive bacteria, gram-negative bacteria, and fungi, as measured by the following method 1.

[0008] [ka]

[0009] In the above Chemical Formula 1, L1 and L2 are the same or different and each independently represents a direct bond; a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; or a substituted or unsubstituted arylene group having 6 to 30 carbon atoms; A is a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms; n is an integer from 0 to 4, R1 and R2 are the same or different and each independently represents a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, and at least one of R1 and R2 is a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms; R3 is an alkyl group having 4 to 20 carbon atoms, When n is 2 or more, two or more As are the same or different,

[0010] [Method 1] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.015 g of the antibacterial composition was added and vortexed. The solution was thoroughly mixed and incubated in a shaking water bath maintained at 35° C. for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0011]

number

[0012] The antibacterial composition according to some embodiments of the present invention contains both hydrophilic and hydrophobic functional groups, which is advantageous in imparting antibacterial properties, and the antibacterial properties are controlled within a specific range, thereby enabling the imparting of safe and excellent antibacterial properties.

[0013] The antibacterial composition according to some embodiments of the present invention has little change in antibacterial activity depending on the amount used, so that it can exhibit antibacterial properties within a predicted range even if unintended concentration variations occur when applied as a product.

[0014] Antibacterial compositions according to some embodiments of the present invention can exhibit antibacterial activity of 80% or more against certain bacteria. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] The present invention will be described in detail below.

[0016] <Antibacterial composition> According to one embodiment of the present invention, there is provided an antibacterial composition comprising a compound represented by the following chemical formula 1, and having an antibacterial activity of 80% or more against at least one strain of gram-positive bacteria, gram-negative bacteria, and fungi, as measured by the following method 1.

[0017] [ka]

[0018] In the above Chemical Formula 1, L1 and L2 are the same or different and each independently represents a direct bond; a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; or a substituted or unsubstituted arylene group having 6 to 30 carbon atoms; A is a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms; n is an integer from 0 to 4, R1 and R2 are the same or different and each independently represents a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, and at least one of R1 and R2 is a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms; R3 is an alkyl group having 4 to 20 carbon atoms, When n is 2 or more, two or more As are the same or different,

[0019] [Method 1] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.015 g of the antibacterial composition was added and vortexed. The solution was thoroughly mixed and incubated in a shaking water bath maintained at 35° C. for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0020]

number

[0021] According to one embodiment of the present invention, the hydrogen is protium ( 1 H, Protium), as well as deuterium ( 2 H, Deuterium) or Tritium ( 3 It may also be a concept including H, Tritium).

[0022] According to one embodiment of the present invention, A is a methyl group.

[0023] According to one embodiment of the present invention, said n is 0.

[0024] According to one embodiment of the present invention, at least one of R1 and R2 is a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms.

[0025] According to one embodiment of the present invention, at least one of R1 and R2 is an unsubstituted alkyl group having 1 to 4 carbon atoms, in other words, each is independently a methyl group; an ethyl group; a propyl group; or a butyl group.

[0026] According to one embodiment of the present invention, R3 is an unsubstituted alkyl group having 4 to 20 carbon atoms.

[0027] According to one embodiment of the present invention, R3 is a substituted or unsubstituted alkyl group having 4 to 16 carbon atoms.

[0028] According to one embodiment of the present invention, R3 is an unsubstituted alkyl group having 4 to 16 carbon atoms.

[0029] According to one embodiment of the present invention, R1 to R3 cannot be simultaneously a methyl group or an ethyl group. That is, when R1 and R2 are the same or different and each independently are a methyl group or an ethyl group, R3 can be an alkyl group having 4 to 16 carbon atoms.

[0030] According to one embodiment of the present invention, R1 to R3 may not simultaneously be a substituted or unsubstituted alkyl group having 4 to 16 carbon atoms. That is, when at least two groups among R1 to R3 are the same or different and are each independently an alkyl group having 4 to 16 carbon atoms, the remaining group (specifically, R1 or R2) may be a methyl group or an ethyl group.

[0031] That is, when R1 to R3 satisfy the above conditions, the compound (quaternary ammonium cation) represented by Chemical Formula 1 can electrostatically adsorb to the anion site on the cell surface of at least one strain of Gram-positive bacteria, Gram-negative bacteria, and fungi, while physicochemically destroying the cell surface structure through hydrophobic interaction, thereby efficiently killing the cells. As a result, the antibacterial activity measured by the above-mentioned method 1 can be improved and reached to a certain level or higher.

[0032] On the other hand, when R1 to R3 do not satisfy the above-mentioned conditions, particularly when R1 to R3 are simultaneously methyl groups or ethyl groups, or simultaneously substituted or unsubstituted alkyl groups having 4 to 16 carbon atoms, the quaternary ammonium cation thus formed does not undergo sufficient hydrophobic interaction to cause cell death, and the antibacterial activity measured by the above-mentioned method 1 may decrease.

[0033] According to one embodiment of the present invention, L1 and L2 are the same or different and each independently represent a direct bond; a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; or a substituted or unsubstituted arylene group having 6 to 30 carbon atoms.

[0034] According to one embodiment of the present invention, L1 and L2 are the same or different and each independently represent a direct bond; or a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms.

[0035] According to one embodiment of the present invention, said L1 is a direct bond.

[0036] According to one embodiment of the present invention, the L2 is an unsubstituted alkylene group having 1 to 4 carbon atoms.

[0037] According to one embodiment of the present invention, L2 is a methylene group; or an ethylene group.

[0038] According to one embodiment of the present invention, said L2 is a methylene group.

[0039] According to one embodiment of the present invention, the compound represented by Chemical Formula 1 is any one selected from the group consisting of the following structures:

[0040] [ka] [ka]

[0041] According to one embodiment of the present invention, the antibacterial activity of the antibacterial composition according to method 1 may be 80% or more, 85% or more, 90% or more, 93% or more, 95% or more, 97% or more, 98% or more, or 99% or more.

[0042] According to one embodiment of the present invention, the bacteriostatic reduction rate (also called antibacterial activity) can be evaluated in the same manner as in Method 1, except that the amount of the antibacterial composition added is changed.

[0043] For example, the bacteriostatic reduction rate may be evaluated in a manner similar to Method 1 above, except that instead of adding 0.015 g of the antimicrobial composition, 0.005 g of the antimicrobial composition is added (Method 2 below), 0.01 g of the antimicrobial composition is added (Method 3 below), or 0.02 g of the antimicrobial composition is added (Method 4 below).

[0044] According to one embodiment of the present invention, the present invention may include an antibacterial composition comprising a compound represented by Chemical Formula 1, and having an antibacterial activity of 50% or more against at least one strain of Gram-positive bacteria, Gram-negative bacteria, and fungi as measured by the following Method 2.

[0045] [Method 2] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.005 g of the antibacterial composition was added and vortexed. The solution was thoroughly mixed and incubated in a shaking water bath maintained at 35° C. for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0046]

number

[0047] According to one embodiment of the present invention, the antibacterial activity of the antibacterial composition according to method 2 may be 50% or more, 55% or more, or 60% or more.

[0048] According to one embodiment of the present invention, the present invention may include an antibacterial composition comprising a compound represented by Chemical Formula 1, and having an antibacterial activity of 70% or more against at least one strain of Gram-positive bacteria, Gram-negative bacteria, and fungi as measured by the following Method 3.

[0049] [Method 3] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.01 g of the antibacterial composition was added and vortexed. The solution was thoroughly mixed and incubated in a shaking water bath maintained at 35° C. for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0050]

number

[0051] According to one embodiment of the present invention, the antibacterial activity of the antibacterial composition according to method 3 may be 70% or more, 75% or more, or 80% or more.

[0052] According to one embodiment of the present invention, the present invention may include an antibacterial composition comprising a compound represented by Chemical Formula 1, and having an antibacterial activity of 90% or more against at least one strain of Gram-positive bacteria, Gram-negative bacteria, and fungi as measured by the following Method 4.

[0053] [Method 4] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.02 g of the antibacterial composition was added and vortexed. The solution was thoroughly mixed and incubated in a shaking water bath maintained at 35° C. for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0054]

number

[0055] According to one embodiment of the present invention, the antimicrobial activity of the antimicrobial composition according to method 4 may be 90% or more, 95% or more, or 99% or more.

[0056] In the present invention, "having antibacterial properties" means that the antibacterial activity (%) is at least 50%, at least 70% or more, preferably 80% or more, more preferably 90% or more, even more preferably 95% or more, or most preferably 99% or more.

[0057] In the present invention, "having antibacterial properties" means that the antibacterial activity (%) measured by Method 1 above is 80% or more, preferably 90% or more, more preferably 95% or more, and most preferably 99% or more.

[0058] In the present invention, "having antibacterial properties" means that the antibacterial activity (%) according to Method 2 above is 50% or more, preferably 55% or more, and most preferably 60% or more.

[0059] In the present invention, "having antibacterial properties" means that the antibacterial activity (%) measured by Method 3 above is 70% or more, preferably 75% or more, and most preferably 80% or more.

[0060] In the present invention, "having antibacterial properties" means that the antibacterial activity (%) measured by Method 4 above is 90% or more, preferably 95% or more, and most preferably 99% or more.

[0061] An antibacterial composition according to one embodiment of the present invention has an antibacterial activity of 80% or more against at least one strain selected from the group consisting of gram-positive bacteria, gram-negative bacteria, and molds, as measured by the following method 1.

[0062] In the antibacterial composition having antibacterial activity, since the strains of gram-positive bacteria, gram-negative bacteria and mold can cause various diseases upon contact and can also cause secondary infections, it is preferable to use one antibacterial agent that exhibits antibacterial properties against all of the gram-positive bacteria, gram-negative bacteria and mold.

[0063] [Method 1] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.015 g of the antibacterial composition was added and vortexed. The thoroughly mixed solution was then cultured for 16 hours in a shaking water bath maintained at 35°C.

[0064] The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0065]

number

[0066] When the antibacterial activity of the antibacterial composition of the present invention was evaluated by the above-mentioned method 1, the antibacterial activity was observed only in cases where it was 90% or more. As a result, it was confirmed that the antibacterial composition of the present invention has excellent antibacterial activity.

[0067] According to one embodiment of the present invention, the Gram-positive bacterium may be any one selected from Enterococcus faecalis, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, and Lactobacillus lactis, but is not limited thereto.

[0068] The Gram-negative bacterium may be any one selected from, but is not limited to, Proteus mirabilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Vibrio cholerae, and Enterobacter cloacae.

[0069] According to one embodiment of the present invention, the fungus may be, but is not limited to, Candida albicans.

[0070] <Manufacturing method> One embodiment of the present invention provides a method for preparing a compound represented by the following Chemical Formula 1:

[0071] According to one embodiment of the present invention, a method for producing a compound represented by the following Chemical Formula 1 includes reacting acetonitrile, a compound represented by the following Chemical Formula 11, and a trialkylamine compound.

[0072] [ka]

[0073] In the above Chemical Formulas 1 and 11, L1 and L2 are the same or different and each independently represents a direct bond; a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; or a substituted or unsubstituted arylene group having 6 to 30 carbon atoms; A is an alkyl group having 1 to 3 carbon atoms, n is an integer from 0 to 4, R1 and R2 are the same or different and each independently represents a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, and at least one of R1 and R2 is a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms; R3 is an alkyl group having 4 to 20 carbon atoms, Hal is a halogen group; When n is 2 or more, two or more As are the same or different.

[0074] In this case, the L1, L2, R1 to R3, A, and n may be the same as those described above in relation to the antibacterial composition.

[0075] According to one embodiment of the present invention, the trialkylamine compound is represented by NR1R2R3, where R1 to R3 are as defined in Formula 1 above.

[0076] <Antibacterial resin> According to one embodiment of the present invention, the antibacterial resin may be a polymer of repeating units derived from one or more compounds represented by Formula 1 contained in the antibacterial composition.

[0077] According to one embodiment of the present invention, the antibacterial resin may be a homopolymer or copolymer of repeating units derived from one or more compounds represented by Chemical Formula 1.

[0078] According to one embodiment of the present invention, the antibacterial resin may contain repeating units derived from one or more compounds represented by Chemical Formula 1, as well as repeating units derived from other compounds.

[0079] Examples of other compounds include, but are not limited to, styrene, acrylonitrile, and the like.

[0080] The copolymer may be an alternating copolymer, a random copolymer, a block copolymer, or a graft copolymer.

[0081] In the present invention, when it is said that a certain member (layer) is located "on" another member (layer), this includes not only the case where a certain member (layer) is in contact with the other member, but also the case where the other member (layer) exists between two members (layers).

[0082] In the present invention, when a part is said to "comprise" a certain component, this does not mean that other components are excluded, but that other components may be further included, unless otherwise specified.

[0083] Hereinafter, the present invention will be described in detail with reference to examples in order to specifically explain the present invention. However, the examples according to the present invention can be modified in various forms, and the scope of the present invention is not to be construed as being limited to the examples described below. The examples of the present invention are provided to more completely explain the present invention to those having average knowledge in the art.

[0084] <Synthesis Example> The reaction scheme of the present invention is as follows:

[0085] [ka]

[0086] In the above reaction formula, R1 and R2 are each independently an alkyl group having 1 to 4 carbon atoms, and R3 is an alkyl group having 1 to 20 carbon atoms.

[0087] Synthesis Example 1: Synthesis of Compound A

[0088] [ka]

[0089] A two-neck round-bottom flask was charged with 50 mL of acetonitrile (ACT) and purged with nitrogen. Then, 20 g of 4-vinylbenzyl chloride (1.0 eq) and 18.6 g of N,N-diethylbutan-1-amine (1.1 eq) were added and stirred at 45°C overnight. The organic solvent was dried under vacuum, and hexane was added and stirred for 1 hour. The resulting solid was washed with hexane and filtered to obtain compound A.

[0090] [MS-H] + =246

[0091] Synthesis Example 2: Synthesis of Compound B

[0092] [ka]

[0093] Compound B was obtained in the same manner as in Synthesis Example 1, except that N-butyl-N-ethylbutan-1-amine was used instead of N,N-diethylbutan-1-amine.

[0094] [MS-H] + =274

[0095] Synthesis Example 3: Synthesis of Compound C

[0096] [ka]

[0097] Compound C was obtained in the same manner as in Synthesis Example 1, except that N-methyl-N-octyloctan-1-amine was used instead of N,N-diethylbutan-1-amine.

[0098] [MS-H] + =372

[0099] Synthesis Example 4: Synthesis of Compound D

[0100] [ka]

[0101] Compound D was obtained in the same manner as in Synthesis Example 1, except that N-decyl-N-methyldecane-1-amine was used instead of N,N-diethylbutan-1-amine.

[0102] [MS-H] + =428

[0103] Comparative Synthesis Example 1: Synthesis of Comparative Compound 1

[0104] [ka]

[0105] Comparative compound 1 was obtained in the same manner as in Synthesis Example 1, except that triethylamine was used instead of N,N-diethylbutan-1-amine.

[0106] [MS-H] + =218

[0107] <Example> Example 1 The antibacterial activity of the antibacterial composition containing Compound A was measured by the following method 1, and is shown in the following Table 1. Proteus mirabilis (ATCC29906) was used.

[0108] [Method 1] 25 mL of broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.015 g of the antibacterial composition shown in Table 1 below was added and vortexed. The solution was thoroughly mixed and cultured in a shaking water bath maintained at 35°C for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula.

[0109]

number

[0110] Examples 2 to 4 and Comparative Example 1 The antibacterial activity was measured in the same manner as in Example 1, except that antibacterial compositions containing compounds B to D and comparative compound 1 were used independently instead of the antibacterial composition containing compound A. The antibacterial activity measurement results are shown in Table 1 below.

[0111] [Table 1]

[0112] However, the Reference is a sample to which no antibacterial composition was added.

[0113] In Table 1, Methods 2 to 4 are similar to Method 1, except that the amounts of the antibacterial compositions shown in Table 1 added are different.

[0114] According to Table 1, when comparing the antibacterial activity measured according to Method 1, the antibacterial compositions of Examples 1 to 4 were all 99.9%, while the antibacterial composition of Comparative Example 1 was 14.3%, indicating that the antibacterial activity of the antibacterial composition containing Comparative Compound 1 was significantly lower than the antibacterial activity of the antibacterial compositions containing Compounds A to D.

Claims

1. The present invention includes one or more compounds represented by the following chemical formula 1: An antibacterial composition having an antibacterial activity of 80% or more against at least one strain of gram-positive bacteria, gram-negative bacteria, and molds, as measured by the following method 1: 【number】 In the above Chemical Formula 1, L1 is a direct bond; a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; or a substituted or unsubstituted arylene group having 6 to 30 carbon atoms; L2 is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms, A is a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms; n is an integer from 0 to 4, R1 and R2 are the same or different and each independently represents a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, and at least one of R1 and R2 is a substituted or unsubstituted alkyl group having 2 to 10 carbon atoms; R3 is an alkyl group having 4 to 20 carbon atoms, When n is 2 or more, two or more A's are the same or different, [Method 1] 25 mL of a broth-type medium (Nutrient broth, BD DIFCO., 8 g / L) inoculated with 3,000 CFU / mL of bacteria was placed in a 50 mL conical tube, and 0.015 g of the antibacterial composition was added and vortexed. The solution was thoroughly mixed and incubated in a shaking water bath maintained at 35° C. for 16 hours. The solution after the completion of incubation is diluted 1 / 5 with 1x PBS buffer solution, and the absorbance (λ=600 nm) is measured using a UV / Vis spectrophotometer. The measured absorbance is compared with that of a solution incubated without the addition of the antibacterial composition, and the antibacterial activity, which is the bacteriostatic reduction rate, is calculated using the following formula. [0010]

2. The antimicrobial composition of claim 1 , wherein the antimicrobial activity is 90% or more.

3. 2. The antibacterial composition according to claim 1, wherein the Gram-positive bacterium is selected from the group consisting of Enterococcus faecalis, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, and Lactobacillus lactis.

4. 2. The antibacterial composition according to claim 1, wherein the Gram-negative bacterium is selected from the group consisting of Proteus mirabilis, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Vibrio cholerae, and Enterobacter cloacae.

5. 2. The antibacterial composition according to claim 1, wherein at least one of R1 and R2 is an unsubstituted alkyl group having 1 to 4 carbon atoms.

6. The antibacterial composition according to claim 1, wherein R3 is an unsubstituted alkyl group having 4 to 16 carbon atoms.

7. 2. The antibacterial composition according to claim 1, wherein R1 and R2 are the same or different and each independently represent a methyl group or an ethyl group, and R3 is an alkyl group having 4 to 16 carbon atoms.

8. The antimicrobial composition of claim 1 , wherein L1 is a direct bond.

9. The antimicrobial composition of claim 1 , wherein L2 is a methylene group.

10. The antibacterial composition according to claim 1, wherein the compound represented by Chemical Formula 1 is any one selected from the group consisting of the following structures: 【Chemistry 2】 【Chemistry 3】

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