Analysis system, management server, analysis device, and program

Abstract

To provide a technique for allowing users to easily evaluate analysis results output from an analysis device.SOLUTION: A LIS 1 receives, from a laboratory technician, evaluation information designating at least one item of contents to be used by an analysis device 3 for deriving analysis results. The LIS 1 transmits an analysis instruction, and a request for the evaluation information to the analysis device 3. The analysis device 3 transmits, to the LIS 1, a value (for example, the name of reagent used for the analysis) of the item designated by the evaluation information together with analysis results. The laboratory technician evaluates the analysis results in the LIS 1 by referring to the value of the item designated by the evaluation information.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present disclosure relates to management of analysis results of samples by an analysis device. [Background technology]

[0002] 2. Description of the Related Art Analytical devices are used in clinical or research applications to analyze samples (e.g., blood or urine). Known examples of such analytical devices include liquid chromatograph-tandem mass spectrometers (LC-MS / MS).

[0003] A system that manages analyses by an analytical device is sometimes called a Laboratory Information System (LIS). The LIS accepts instructions for the analytical device from a user (e.g., a laboratory technician). The LIS also presents the analysis results output from the analytical device to the user.

[0004] In addition to the LIS, hospitals may also use a management device called a Hospital Information System (HIS). The HIS is a system for transmitting analysis instructions from doctors to the LIS. Patent Document 1 (JP Patent Publication 2020-51838 A) discloses a configuration in which a hospital uses an LIS and an HIS to manage analysis by an analyzer. In this configuration, the LIS reports the analysis results output from the analyzer to the HIS. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2020-51838 A Summary of the Invention [Problem to be solved by the invention]

[0006] The user evaluates the analysis results presented by the LIS from the viewpoint of whether or not they can be used as final analysis results (for example, in reporting to the HIS). In this evaluation, the user determines whether or not the analysis by the analysis device was performed properly. In the technology described in Patent Document 1, when the user determines that the analysis was performed properly, the user causes the LIS to report the analysis results to the HIS.

[0007] If it is determined that the analysis has not been performed properly, the user will closely examine information that may affect the analysis (e.g., reagent information, calibration curves, mass spectra, etc.). In such cases, the user is required to go to the analytical device to check the information that may affect the analysis as necessary. In other words, the user is required to take the extra effort and time to go to the analytical device to check the above information in order to evaluate the analysis results.

[0008] The present disclosure has been made in view of the above circumstances, and has as its purpose to provide a technique that enables a user to easily evaluate analysis results output from an analysis device. [Means for solving the problem]

[0009] A first aspect of the present invention relates to an analytical system comprising an analytical device and a management server that manages analysis in the analytical device, the management server including an input unit that accepts input of analysis instructions and evaluation information for each sample, and a first communication interface that transmits the analysis instructions and a request for the evaluation information to the analytical device, the evaluation information specifying at least one item of content used by the analytical device to derive an analysis result, the analytical device including an analysis unit that derives an analysis result by analyzing a sample in accordance with the analysis instructions, and a second communication interface that transmits the analysis result and values ​​of items specified by the evaluation information among the content used to derive the analysis result to the management server, and the management server further including an output unit that outputs the analysis result and the value of the item specified by the evaluation information.

[0010] A second aspect of the present invention relates to a management server that manages an analytical device that analyzes samples, the management server further comprising an input unit that accepts input of analysis instructions and analysis evaluation information for each sample, the evaluation information specifying at least one item of content that the analytical device uses to derive an analysis result, a communications interface that transmits the analysis instructions and a request for the evaluation information to the analytical device, and an output unit that outputs the analysis results transmitted from the analytical device in response to the analysis instructions and the values ​​of the items specified by the evaluation information.

[0011] A third aspect of the present invention relates to an analytical device for analyzing samples, comprising a communication interface for receiving, for each sample, an analysis instruction and a request for analysis evaluation information from a management server, the evaluation information specifying at least one item of content that the analytical device uses to derive an analysis result for the sample, and further comprising an analysis unit for deriving an analysis result by analyzing the sample in response to the analysis instruction, and the communication interface for transmitting the analysis result and values ​​of the items specified by the evaluation information to the management server.

[0012] A fourth aspect of the present invention relates to a program that, when executed by a management server computer, causes the computer to implement a method for managing analysis results obtained by an analytical device, the method including the step of accepting input of analysis instructions and analysis evaluation information for each sample, the evaluation information specifying at least one of the contents used by the analytical device to derive an analysis result, the method further including the steps of transmitting the analysis instructions and a request for the evaluation information to the analytical device, and outputting the analysis results transmitted from the analytical device in response to the analysis instructions and values ​​of items specified by the evaluation information. Effect of the Invention

[0013] According to the present disclosure, the evaluation information specifies at least one of one or more items of content used by the analysis device to derive the analysis result. The management server acquires the analysis result and the value of the item specified by the evaluation information from the analysis device. A user of the management server can check the value of the item specified by the evaluation information and evaluate the analysis result. This allows the user to evaluate the analysis result without having to take the trouble of traveling to the analysis device. [Brief description of the drawings]

[0014] [Figure 1] 1 is a schematic diagram showing a configuration of an analysis system 100 according to an embodiment of the present invention. [Diagram 2] FIG. 2 is a diagram showing a flow when the evaluation received in step (11) of FIG. 1 is “inappropriate.” [Diagram 3] FIG. 2 is a diagram illustrating an example of a hardware configuration of an HIS 5. [Figure 4] FIG. 2 is a diagram illustrating an example of a hardware configuration of the LIS1. [Diagram 5] FIG. 2 is a diagram showing an example of the configuration of an analysis device 3. [Figure 6] FIG. 2 is a diagram showing an example of an input screen SC1. [Figure 7] FIG. 13 is a diagram showing another example of the input screen SC1. [Figure 8] FIG. 13 is a diagram showing an example of a result screen SC2. [Figure 9] 1 is a flowchart of processes executed in the HIS 5, the LIS 1, and the analyzer 3, respectively. [Figure 10] 1 is a flowchart of processes executed in the HIS 5, the LIS 1, and the analyzer 3, respectively. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. In the following, the same or corresponding parts in the drawings are given the same reference characters, and their descriptions will not be repeated in principle.

[0016] [1. Analysis system configuration]

[0017] 1 is a schematic diagram showing the configuration of an analysis system 100 according to an embodiment of the present invention. In one implementation example, the analysis system 100 is implemented as a system for managing analysis results of samples collected from patients in a medical institution such as a hospital. The analysis system 100 includes an LIS 1, an analysis device 3, and an HIS 5.

[0018] The LIS 1 electronically manages operations related to clinical testing. The LIS 1 is exemplified as a server operated by a laboratory technician and managing analysis in the analysis device 3. The laboratory technician is an example of a user of the LIS 1.

[0019] The analytical device 3 analyzes a sample to derive an analysis result of the sample. The sample is, for example, blood, urine, or other metabolites. The analytical device 3 may be an LC-MS / MS as described below with reference to FIG. 5, but may be any other type of device capable of deriving an analysis result of the sample by qualitative and / or quantitative analysis. The analytical device 3 and the LIS 1 are connected by wire or wirelessly. In the example of FIG. 1, the analytical device 3 and the LIS 1 are connected via a network 7A.

[0020] The HIS 5 electronically manages the operations of the hospital and is also called an electronic medical record. The HIS 5 is exemplified as a server that manages test instructions and results from doctors or nurses, as well as diagnosis details. The HIS 5 and the LIS 1 are connected by wire or wirelessly. In the example of FIG. 1, the HIS 5 and the LIS 1 are connected via a network 7B.

[0021] [2. Overview of processing in the analysis system]

[0022] 1, (1) to (14) indicate the order of processing performed in analysis system 100. The flow of processing will be described below with reference to (1) to (14).

[0023] In step (1), the HIS 5 accepts input of a test item. A test item specifies the type of value expected to be output from the analysis device 3. For example, when a doctor wants to determine whether a patient is suffering from a certain disease, the doctor needs the blood concentration of a substance that serves as a marker for the disease. In this case, the doctor inputs the blood concentration of the substance into the HIS 5 as a test item.

[0024] In step (2), the HIS 5 transmits an instruction for an examination to the LIS 1. The instruction for an examination includes an examination item.

[0025] In step (3), a sample is taken from the patient. The type of sample taken corresponds to the test item entered into HIS5 in step (1). For example, if the test item is the blood concentration of a given substance, blood is taken from the patient. The person taking the sample from the patient can be identified depending on the type of sample. For example, if blood is taken as the sample, a person with given qualifications, such as a doctor or nurse, takes the sample. If urine is taken as the sample, the patient himself may take the sample.

[0026] In step (4), the sample is placed in the analysis device 3. The sample is placed, for example, by a laboratory technician.

[0027] In step (5), the analysis device 3 inquires of the LIS 1 about the analysis items of the sample.

[0028] In step (6), the LIS 1 receives the analysis items and the evaluation information.

[0029] Like the test item, the analysis item specifies the type of value expected to be output from the analysis device 3. The laboratory technician may directly input the test item transmitted from the HIS 5 to the LIS 1 in step (2) as the analysis item to the LIS 1. The laboratory technician may also input the test item included in the test instruction and other items related to the test item as the analysis items to the LIS 1.

[0030] The evaluation information is information that specifies at least one of one or more items used to derive an analysis result in the analysis device 3. In one implementation example, the evaluation information specifies a reagent used in the analysis. The one or more items used to derive an analysis result in the analysis device 3 and the evaluation information will be described later with reference to FIG.

[0031] In step (7), the LIS 1 transmits an analysis instruction and a request for evaluation information to the analysis device 3. The analysis instruction includes the analysis items input in step (6).

[0032] In step (8), the analysis device 3 performs analysis of the sample based on the analysis instruction from the LIS 1.

[0033] In step (9), the analytical device 3 transmits the analysis results and values ​​of items specified by the evaluation information to the LIS 1. The analytical device 3 derives the analysis results according to the analysis items included in the analysis instructions from the LIS 1 and transmits them to the LIS 1. The analytical device 3 identifies values ​​of items specified by the evaluation information and transmits them to the LIS 1. For example, if the evaluation information specifies a reagent used in the analysis, the analytical device 3 reads information specifying the reagent (e.g., the reagent name) from a given storage device within the analytical device 3 and transmits it to the LIS 1.

[0034] In step (10), the LIS 1 outputs the information transmitted from the analysis device 3 in step (9). That is, the LIS 1 outputs the analysis result and the value of the item specified by the evaluation information. The laboratory technician evaluates the analysis result. The laboratory technician can further evaluate the analysis result by referring to the value of the item specified by the evaluation information.

[0035] In step (11), the LIS 1 receives an evaluation of the analysis result from the laboratory technician. In one implementation example, the evaluation is input as either "good" or "bad."

[0036] Step (12) is performed when the value “good” is input as the evaluation. In step (12), the LIS 1 transmits the analysis result transmitted from the analysis device 3 in step (9) to the HIS 5 as the test result.

[0037] In step (13), the HIS 5 outputs the test results, and the doctor checks the test results.

[0038] In step (14), the physician makes a diagnosis based on the test results.

[0039] Fig. 2 is a diagram showing the flow when the evaluation received in step (11) in Fig. 1 is "inappropriate." In Fig. 2, (21) to (24) indicate the order of processing performed after step (11) in the analysis system 100. In the example of Fig. 2, after step (11), the processing of the LIS1 proceeds to step (21).

[0040] In step (21), the LIS 1 receives a reanalysis instruction and evaluation information from a laboratory technician. The reanalysis instruction includes analysis items, similar to the analysis instruction in step (7).

[0041] In step (22), the LIS 1 transmits to the analysis device 3 an instruction for reanalysis and a request for evaluation information.

[0042] In step (23), the analysis device 3 performs a reanalysis of the sample based on the reanalysis instruction.

[0043] In step (24), the analyzer 3 transmits to the LIS 1 the analysis results of the reanalysis and the values ​​of the items specified in the evaluation information (step (22)).

[0044] Thereafter, in the analysis system 100, processing proceeds in the same manner as that from step (10) in FIG. 1 described above. That is, in step (10), the LIS1 outputs the analysis results of the reanalysis and the values ​​of the items specified by the evaluation information. The laboratory technician can evaluate the analysis results of the reanalysis by checking the analysis results of the reanalysis and by referring to the values ​​of the items specified by the evaluation information. The LIS1 then accepts an evaluation of the analysis results from the laboratory technician.

[0045] According to the flow described with reference to FIG. 1 and FIG. 2, the LIS 1 obtains not only the analysis result but also the value of the item specified by the evaluation information. The value of the item specified by the evaluation information is used to determine whether or not the analysis result is to be transmitted to the HIS 5. Decision This can be used not only for the purpose of analysis, but also for evaluating the analysis results after the fact, which allows laboratory technicians to easily respond to requests for traceability of analysis results after the fact.

[0046] [3. Hardware configuration]

[0047] (1)HIS

[0048] Fig. 3 is a diagram showing an example of a hardware configuration of the HIS 5. With reference to Fig. 3, the HIS 5 includes a processor 50, a storage unit 51, an I / O (Input / Output) interface 53, a communication interface 55, a display 56, and an input unit 57.

[0049] The processor 50 controls the entire HIS 5, and in one implementation example, is realized by at least one CPU (Central Processing Unit).

[0050] The storage unit 51 is realized by, for example, a Read Only Memory (ROM), a Random Access Memory (RAM) and / or a Hard Disk Drive (HDD). The ROM can store a program executed by the processor 50. The RAM can temporarily store data used during execution of a program in the processor 50, and can function as a temporary data memory used as a working area. The HDD is a non-volatile storage device. In addition to the HDD, or instead of the HDD, a semiconductor storage device such as a flash memory may be adopted. The above programs and / or data may be stored in an external storage device accessible by the processor 50.

[0051] The storage unit 51 includes a program storage area 510 and a data storage area 511. The HIS 5 is configured to operate according to a program stored in the program storage area 510. The program storage area 510 stores, for example, a program for issuing an analysis instruction to the LIS 1. The data storage area 511 stores, for example, the examination results of a patient.

[0052] The communication interface 55 is an interface for the HIS 5 to communicate with an external device (eg, the LIS 1) wirelessly or via wire.

[0053] The I / O interface 53 is an interface for inputting an external signal to the HIS 5 or outputting a signal from the HIS 5 to an external device. The HIS 5 is connected to an input unit 57 and a display 56 via the I / O interface 53.

[0054] The input unit 57 receives input from a medical technician. The input includes instructions for the HIS 5. The input unit 57 is realized by an input device. The input device is, for example, a keyboard, a mouse, and / or a touch panel that is integral with the display screen of the display 56.

[0055] The display 56 is an example of a display device, such as a liquid crystal display.

[0056] In the above description, the HIS 5 is described as a single server, but is not limited thereto. The HIS 5 may be realized by two or more computers working together. For example, the HIS 5 may be configured by a server including a storage unit 51 and a terminal that communicates with the server. In one embodiment, the terminal is owned by a doctor and includes an input unit 57 and a display 56.

[0057] (2)LIS

[0058] Fig. 4 is a diagram showing an example of a hardware configuration of the LIS 1. With reference to Fig. 4, the LIS 1 includes a processor 10, a storage unit 11, an I / O interface 13, a communication interface 15, a display 16, and an input unit 17.

[0059] The processor 10 controls the entire LIS 1, and in one implementation example, is realized by at least one CPU.

[0060] The storage unit 11 is realized by, for example, a ROM, a RAM, and / or a HDD. The ROM can store a program executed by the processor 10. The RAM can temporarily store data used during execution of the program in the processor 10, and can function as a temporary data memory used as a working area. The HDD is a non-volatile storage device. In addition to the HDD, or instead of the HDD, a semiconductor storage device such as a flash memory may be adopted. The above-mentioned program and / or data may be stored in an external storage device accessible by the processor 10.

[0061] The storage unit 11 includes a program storage area 110 and a data storage area 111. The LIS 1 is configured to operate according to a program stored in the program storage area 110. The program storage area 110 stores, for example, a program related to a request for evaluation information or the like.

[0062] The communication interface 15 is an interface for the LIS 1 to communicate with external devices (eg, the HIS 5 and the analyzer 3).

[0063] The I / O interface 13 is an interface for inputting an external signal to the LIS 1, or for outputting a signal from the LIS 1 to an external device. The LIS 1 is connected to an input unit 17 and a display 16 via the I / O interface 13.

[0064] The input unit 17 receives input from a medical technician. The input includes instructions for the LIS 1. The input unit 17 is realized by an input device. The input device is, for example, a keyboard, a mouse, and / or a touch panel that is integral with the display screen of the display 16.

[0065] The display 16 is an example of a display device, such as a liquid crystal display.

[0066] In the above description, the LIS1 has been described as a single server, but is not limited to this. The LIS1 may be realized by two or more computers working together. For example, the LIS1 may be configured by a server including a storage unit 11 and a terminal that communicates with the server. In one embodiment, the terminal is owned by a laboratory technician and includes an input unit 17 and a display 16.

[0067] (3) Analyzer

[0068] Fig. 5 is a diagram showing an example of the configuration of the analysis device 3. Referring to Fig. 5, the analysis device 3 is, for example, an LC-MS / MS, and includes a control unit 300, a storage unit 32, a detection unit 33, a pre-processing unit 34, a liquid chromatograph 38, and a mass analyzer 39. The liquid chromatograph may be abbreviated as LC. The mass analyzer may be abbreviated as MS.

[0069] The control unit 300 controls the storage unit 32, the detection unit 33, the pre-processing unit 34, the liquid chromatograph 38, and the mass analyzer 39. The control unit 300 includes a processor 30, a memory unit 31, a communication interface 35, a display 36, and an input unit 37.

[0070] The processor 30 controls the entire analysis device 3, and in one implementation example, is realized by at least one CPU.

[0071] The storage unit 31 is realized by, for example, a ROM, a RAM, and / or a HDD. The ROM can store a program executed by the processor 30. The RAM can temporarily store data used during execution of the program in the processor 30, and can function as a temporary data memory used as a working area. The HDD is a non-volatile storage device. In addition to the HDD, or instead of the HDD, a semiconductor storage device such as a flash memory may be adopted. The above programs and / or data may be stored in an external storage device accessible by the processor 30.

[0072] The memory unit 31 includes a program storage area 310 and a data storage area 311. The analysis device 3 is configured to operate according to a program stored in the program storage area 310. The program storage area 310 stores, for example, a program related to the control of the analysis device 3. The data storage area 311 stores, for example, analysis conditions, basic data, and the like.

[0073] The communication interface 35 is an interface for the analytical device 3 to communicate with an external device (eg, the LIS 1).

[0074] The input unit 37 receives input from a laboratory technician. The input includes instructions for the analysis device 3. The input unit 37 is realized by an input device. The input device is, for example, a display. 36 The touch panel, buttons, and / or switches are integrally configured with the display screen.

[0075] The display 36 is an example of a display device, such as a liquid crystal display.

[0076] The storage unit 32 stores samples stored in a predetermined container by an operator (e.g., a laboratory technician). The analysis device 3 may have a mechanism (transport system) for automatically storing samples in the storage unit 32.

[0077] The detection unit 33 detects the storage of a sample in the storage unit 32 and reads information identifying the sample stored in the storage unit 32 (sample ID). The detection unit 33 includes, for example, an optical sensor for detecting the storage of a sample. The detection unit 33 also includes a barcode reader for detecting the sample ID. For example, an identifier indicating the sample ID is attached to the sample container. The identifier may be a barcode or any other type of identifier (QR code (registered trademark), IC chip, etc.). The sample ID may be associated with the ID of the subject (e.g., patient) from whom the sample was collected, the date and time the sample was collected, and / or the type of sample (e.g., urine, blood).

[0078] The pretreatment section 34 performs pretreatment on the sample to prepare it in a state suitable for measurement by the liquid chromatograph 38 and / or the mass spectrometer 39. The pretreatment includes, for example, at least one of denaturation of proteins in the sample, removal of impurities, extraction or derivatization of a target component, dilution, concentration, enzyme treatment, and centrifugation.

[0079] The liquid chromatograph 38 separates the sample into its components.

[0080] The mass analyzer 39 may be a tandem mass spectrometer, and obtains a mass chromatogram by measurement. The mass analyzer 39 also measures the mass spectrum of each component of the sample introduced from the liquid chromatograph 38, and identifies each component of the sample by comparing the pattern of the mass spectrum with a given database. Furthermore, the mass analyzer 39 outputs the concentration value of each component by calculating the ratio of the peak value corresponding to each component of the sample to the peak value of a standard substance.

[0081] In the analysis device 3, the liquid chromatograph 38 and / or the mass analyzer 39 derive the measurement results of the sample and the concentration values ​​of various substances. The concentration values ​​of the substances are an example of an analysis result. In this sense, in the analysis device 3, the pre-processing unit 34, the liquid chromatograph 38, and the mass analyzer 39 constitute an analysis unit that derives the analysis results. The analysis unit performs qualitative analysis and / or quantitative analysis to derive the analysis results. Qualitative analysis is, for example, component identification by matching a mass spectrum pattern with a database. Quantitative analysis is, for example, measurement of the concentration values ​​of substances using the peak areas of a mass chromatogram.

[0082] In one implementation example, the contents used to derive the analysis results in each of the pre-processing unit 34, the liquid chromatograph 38, and the mass analyzer 39 are stored in the memory unit 31. In response to a request for evaluation information from the LIS1, the processor 30 reads out values ​​of items specified in the evaluation information from the information stored in the memory unit 31.

[0083] In the above description, the analysis device 3 has been described as a device in which the control unit 300, the pre-processing unit 34, the liquid chromatograph 38, and the mass analyzer 39 are integrated, but the present invention is not limited to this. The analysis device 3 may be configured by an assembly of one or more computers and one or more analytical instruments. For example, the pre-processing unit 34 may be an independent device with respect to the liquid chromatograph 38 and the mass analyzer 39. The control unit 300 may be included in the pre-processing unit 34, or may be included in the liquid chromatograph 38 and the mass analyzer 39. The control unit 300 may be configured by a computer having a storage unit 31 and a terminal that communicates with the computer. The terminal has an input unit 37 and a display 36.

[0084] [4. Comparison with conventional analysis systems]

[0085] In a conventional analytical system, a laboratory technician uses an LIS to send instructions for analyzing a sample to an analytical device. The analysis may be a quantitative analysis (e.g., measuring the concentration of a specific component) or a qualitative analysis (e.g., simultaneous screening of multiple components). In response to the instructions, the analytical device sent the analysis results to the LIS. The laboratory technician checked the analysis results from the analytical device using the LIS.

[0086] When a laboratory technician checks an analysis result, the technician may have doubts about the accuracy of the analysis. In such a case, the technician must go to the analyzer (where the analyzer is installed) to check the contents used to derive the analysis result (e.g., the reagents used in the analysis, the mass chromatogram, etc.). In other words, the user is required to take the additional task of traveling to the analyzer to evaluate the analysis result.

[0087] On the other hand, in the analysis system 100 according to the present embodiment, at least one item of the contents used for deriving the analysis result is input as the evaluation information. More specifically, the laboratory technician inputs the evaluation information to the LIS1. In response to this, the LIS1 transmits a request for the evaluation information together with an instruction for analysis to the analysis device 3. The analysis device 3 transmits the value of the item specified by the evaluation information together with the analysis result to the LIS1. This allows the laboratory technician to refer to the value of the item specified by the evaluation information together with the analysis result and evaluate the analysis result. Since the value of the item specified by the evaluation information is transmitted to the LIS1 together with the analysis result, the laboratory technician is not required to perform the additional work described above to confirm the value. Therefore, the analysis system 100 contributes to improving the work efficiency of the quality control of the analysis system.

[0088] [5. User Interface]

[0089] Next, a user interface displayed in the LIS 1 will be described with reference to Figures 6 to 8. Each screen shown in Figures 6 to 8 is displayed on the display 16 by, for example, the processor 10 of the LIS 1 executing a given application.

[0090] (1. Input screen)

[0091] 6 is a diagram showing an example of the input screen SC1. The input screen SC1 is displayed to receive input of analysis items and evaluation information from a laboratory technician (step (6) in FIG. 1). The input screen SC1 includes fields SC11 to SC14.

[0092] The field SC11 includes a sample ID. The field SC11 further includes a send button for sending the selection made by the laboratory technician on the input screen SC1 to the analysis device 3.

[0093] Column SC12 includes general items. General items refer to general information items related to the analysis by the analysis device 3. In the example of Fig. 6, the general items include "analyst," "analysis date and time," and "whether or not reanalysis was performed in the analysis device."

[0094] Column SC13 includes analysis items, in the example of Fig. 6, concentration values ​​of a plurality of substances (substances X, Y, Z) are shown as analysis items.

[0095] Column SC14 includes auxiliary items. The auxiliary items correspond to the above-mentioned "contents used to derive the analysis results."

[0096] In the example of Figure 6, the following items are displayed as auxiliary items: "Reagent information," "Consumables information," "Calibration curve information," "Software used," "Information used for component identification," "Pretreatment protocol information," "Analysis method information," "Mass spectrum," and "Mass chromatogram."

[0097] The auxiliary items can be classified into analytical conditions and basic data. Each of "reagent information," "consumables information," "calibration curve information," "software used," "information used for component identification," "pretreatment protocol information," and "analysis method information" is a specific example of analytical conditions. Each of "mass spectrum" and "mass chromatogram" is a specific example of basic data.

[0098] Analytical conditions refer to the settings in the analytical device 3 for the analysis of a sample.

[0099] The basic data refers to data acquired by the analysis device 3 for a sample in order to derive a final analysis result for the sample. For example, in order to acquire a concentration value of substance Y in a sample, the analysis device 3 acquires a mass chromatogram of the sample. Then, the analysis device 3 derives the concentration value of substance Y in the sample by using a peak area value of the mass chromatogram. In this case, the concentration value of substance Y corresponds to the analysis item, and the mass chromatogram corresponds to the basic data.

[0100] Each item of the analysis conditions will be described below. "Reagent information" refers to the reagent used to derive the analysis result of the sample, for example, the reagent of the standard substance used to derive the concentration value of a given substance in the mass spectrometer 39.

[0101] “Consumables information” refers to consumables used in the analysis device 3, for example, a reagent used to clean the mass analyzer 39.

[0102] "Calibration curve information" refers to the calibration curve used to derive the analysis results. In the example of FIG. 6, "calibration curve information" is subdivided into graph, creator, creation date and time, and reagents / consumables used. Graph refers to the graph of the calibration curve. Creator refers to the creator of the calibration curve. Creation date and time refers to the date and time when the calibration curve was created. Reagents / consumables used refers to the reagents and consumables used to create the calibration curve.

[0103] "Software used" refers to software used to derive analytical results or a database containing information necessary for component identification. For example, software used to derive a concentration value of a given substance in mass spectrometer 39. An example of this software is software used in mass spectrometer 39 to calculate a concentration value of a given substance from a mass chromatogram.

[0104] "Information used to identify a component" means information used as the basis for a component's identification when that component is identified as part of deriving an analytical result.

[0105] “Pre-processing protocol information” refers to information that defines the protocol used in the pre-processing unit 34 .

[0106] "Analysis method information" refers to information that specifies the method used to derive the analysis results.

[0107] Each item of basic data will be explained below. "Mass spectrum" and "mass chromatogram" refer to the mass spectrum and mass chromatogram, respectively, used to calculate the results of the analysis (identification or concentration value of components).

[0108] In the input screen SC1, the columns SC13 and SC14 further include check boxes corresponding to the respective items. The technician checks the check boxes in the column SC13 to designate the items corresponding to the check boxes as analysis items. The technician checks the check boxes in the column SC14 to designate the items corresponding to the check boxes as evaluation information.

[0109] The items included in the input screen SC1 described above with reference to FIG. 6 are merely examples. For example, the items constituting the auxiliary items are not limited to those displayed in column SC14. The items included in column SC12 as general items may constitute the auxiliary items. Furthermore, the auxiliary items may include other items other than the items included in column SC14. The other items are, for example, a matching library or a specimen type (unknown specimen / calibration / QC sample).

[0110] The input screen SC1 shown in Fig. 6 is displayed at the time of step (2) in Fig. 1 (the time when the HIS5 issues an instruction for testing to the LIS1). That is, the input screen SC1 shown in Fig. 6 displays the contents of the instruction for testing sent from the HIS5 (the test items included in the instruction for testing). For this reason, in the state shown in Fig. 6, only the check box corresponding to the item (concentration value of substance Y) corresponding to the instruction for analysis from the doctor is checked.

[0111] Fig. 7 is a diagram showing another example of the input screen SC1. The input screen SC1 shown in Fig. 7 is displayed at the time of step (6) in Fig. 1, that is, at the time when the LIS1 receives the analysis items and evaluation information from the laboratory technician.

[0112] In the input screen SC1 in Fig. 7, the check boxes that were not checked in the state shown in Fig. 6 are now checked. This means that the technician performed the operation to check the boxes in step (6) in Fig. 1.

[0113] For example, in the field SC1 of the input screen in Figure 7, 12 Now, the items "analyzer," "analysis date and time," and "whether or not reanalysis was performed on the analyzer," which were not checked on the input screen SC1 in Figure 6, have been checked. This means that the laboratory technician has checked these items.

[0114] Also, in the SC1 input screen in Figure 7, 13 In this screen, the item "Concentration value of substance Z" that was not checked on the input screen SC1 in Figure 6 is now checked. This means that when the doctor specifies only "Concentration value of substance Y" as the test item, the technician can also specify "Concentration value of substance Z" as an analysis item.

[0115] When the send button is operated on the input screen SC1 in Fig. 7, the LIS1 transmits a test instruction and a request for evaluation information to the analysis device 3, as described as step (7) in Fig. 1. The test instruction includes the test item. The test item is the item checked in the field SC13. The requested evaluation information specifies the item checked in the field SC14.

[0116] In the example of Fig. 7, the LIS1 accepts input of evaluation information by accepting a check in a check box in the column SC14. The LIS1 accepts an instruction for analysis by accepting an operation of the send button. The instruction for analysis includes information on which check box is checked in the column SC13.

[0117] (2.Result screen)

[0118] 8 is a diagram showing an example of the result screen SC2. The result screen SC2 is displayed as an example of output of the analysis result and the value of the item specified by the evaluation information, which is described as step (10) in FIG.

[0119] As shown in FIG. 8, the result screen SC2 includes columns SC21 to SC 24 Includes.

[0120] Field SC21, like field SC11 of input screen SC1, includes a sample ID. Field SC21 further includes a report button and a reanalysis button. In one implementation, the report button corresponds to a "good" evaluation of the analysis result, and the reanalysis button corresponds to a "bad" evaluation of the analysis result.

[0121] If the laboratory technician evaluates the analysis results as appropriate, he or she operates the report button. This causes the LIS 1 to transmit the analysis results to the HIS 5 as test results. If the laboratory technician evaluates the analysis results as inappropriate, he or she operates the reanalysis button. This causes the LIS 1 to transmit a reanalysis instruction to the analyzer 3. The reanalysis instruction includes the analysis items.

[0122] In one embodiment, the analysis items included in the reanalysis instruction may be the same as the analysis items included in the analysis instruction. In another embodiment, the LIS1 may display the input screen SC1 again in response to the operation of the reanalysis button. The analysis items set on the input screen SC1 at this time may be the analysis items included in the reanalysis instruction.

[0123] The LIS1 transmits a request for evaluation information together with an instruction for reanalysis to the analysis device 3. In one embodiment, the evaluation information targeted by the request transmitted together with the instruction for reanalysis may be the same as the evaluation information targeted by the request transmitted together with the instruction for analysis. In another embodiment, the LIS1 may display the input screen SC1 again in response to an operation of the reanalysis button. The evaluation information set on the input screen SC1 at this time may be the evaluation information targeted by the request transmitted together with the instruction for reanalysis.

[0124] Column SC22 includes general items, similar to column SC12 on input screen SC1, and further includes values ​​of the general items. For example, column SC22 includes the item "Analysis Implementer" and its value "Yamada Taro." Among the items included in column SC22, column SC22 includes values ​​only for items that were checked on input screen SC1.

[0125] Column SC23 includes analysis items, similar to column SC13 on input screen SC1, and further includes values ​​of the analysis items. The values ​​of the analysis items correspond to the analysis results. For example, column SC23 includes an item "concentration value of substance Y" and a value "1.0 mg / L." The item "concentration value of substance Y" is an example of an analysis item, and the value "1.0 mg / L" is an example of an analysis result. Column SC23 includes an item "concentration value of substance Z" and a value "error flag AA." The item "concentration value of substance Z" is another example of an analysis item, and the value "error flag AA" is another example of an analysis result. The value "error flag AA" means that the analysis of the corresponding analysis item was not completed normally, and the classification of the cause (error flag AA).

[0126] Column SC23 contains values ​​only for those items that were checked in input screen SC1 among the items contained in column SC23. Column SC23 contains the item "Concentration value of substance X," but does not contain a value for this item. This means that the check box for the item "Concentration value of substance X" was not checked in input screen SC1.

[0127] Column SC24 includes auxiliary items, similar to column SC14 on input screen SC1, and further includes values ​​of the auxiliary items. For example, column SC24 includes an item "reagent information" and its value "reagent A (lot ABC)." "Reagent A" is an example of a name of a reagent. "Lot ABC" is information that specifies the lot number used in the analysis device 3. That is, the analysis device 3 transmits the name and lot number of the reagent to the LIS1 as values ​​of the items specified by the evaluation information, and the LIS1 displays the name and lot number of the reagent in column SC24.

[0128] Column SC24 may indirectly display the value of an item. In the example of FIG. 7, file link information (calibration curve graph link) is shown as the value of the item "graph" in the item "calibration curve information". When the link information is clicked, LIS1 reads out the image file of the calibration curve graph and displays it on the display 16. In this case, the analysis device 3 transmits the image file of the calibration curve graph to LIS1 as the value of the item specified by the evaluation information. LIS1 displays the link information in column SC24 instead of directly displaying the image file.

[0129] Column SC24 contains values ​​only for those items that were checked on input screen SC1 among the items contained in column SC24. Column SC24 contains the item "mass chromatogram," but does not contain a value for this item. This means that the check box for the item "mass chromatogram" was not checked on input screen SC1.

[0130] As explained with reference to FIG. 7, the auxiliary items are information " is included. If this item is checked on the input screen SC1, the laboratory technician can check the name of the reagent on the result screen SC2. This enables the laboratory technician to notice if a reagent other than the one that should be used for the analysis of the specified analysis item has been mistakenly used in the analysis.

[0131] In the result screen SC2, the item "Reagent information The value of " includes a lot number. This allows a laboratory technician to know if a reagent that is too old has been used in a test, or if a reagent from a lot that may cause abnormalities in the analysis results has been used.

[0132] The value of the item "Graph" on the result screen SC2 corresponds to the image file of the calibration curve graph. That is, the laboratory technician can check the image file of the calibration curve graph using the result screen SC2. This allows the laboratory technician to notice if the calibration curve graph itself, which is the basis of the analysis, is abnormal.

[0133] The result screen SC2 is the item " use These include values ​​for "software," "information used for component identification," "pretreatment protocol information," and "analysis method information." By referring to these values, laboratory technicians can comprehensively examine factors that may make an analysis inappropriate.

[0134] The result screen SC2 further includes values ​​of basic data ("mass spectrum" and "mass chromatogram"). The values ​​of the items "mass spectrum" and "mass chromatogram" are, for example, two-dimensional data. By checking the two-dimensional data as the values ​​of the basic data, the laboratory technician can confirm whether the data measured as the premise of the analysis results was normal in evaluating the analysis results. The two-dimensional data is checked from the viewpoint of, for example, whether the S / N ratio is normal, whether the chromatogram waveform is normal, etc.

[0135] In the analysis system 100, the laboratory technician can specify items as evaluation information for each sample on the input screen SC1. The result screen SC2 displays the values ​​of the specified items for each sample. That is, the laboratory technician can obtain the minimum necessary information for each sample. This can prevent the laboratory technician from being burdened with too much information when evaluating the analysis results.

[0136] As exemplified by the value "Error Flag AA", the value displayed as the analysis result may indicate the reason why the analysis was not completed normally. Even in such a case, the laboratory technician can evaluate the analysis result by referring to the value of the auxiliary item displayed in column SC24.

[0137] [6. Processing flow in the analysis system]

[0138] 9 and 10 are flowcharts of processes executed in the HIS 5, the LIS 1, and the analyzer 3, respectively. In one implementation example, the processes shown in Fig. 9 and 10 are realized by the processor 50 of the HIS 5, the processor 10 of the LIS 1, and the processor 30 of the control unit 300 of the analyzer 3, respectively, executing a given program.

[0139] First, referring to FIG. 9, in step S502, the HIS 5 accepts input of examination items from a doctor.

[0140] In step S504, the HIS 5 transmits an instruction for the test including the test item to the LIS 1.

[0141] In step S506, the HIS 5 outputs an instruction to collect a sample. The output of the instruction is, for example, a display of the instruction on the display 56. Based on the instruction from the HIS 5, a sample is collected from the patient. In one implementation example, a nurse collects a sample from the patient. The collected sample is stored in the analysis device 3.

[0142] In step S102, the LIS 1 stores the test items transmitted from the HIS 5 in the storage unit 11.

[0143] In step S302, when the analysis device 3 detects the storage of the sample, it reads the sample ID from the identifier attached to the sample.

[0144] In step S304, the analyzer 3 sends to the LIS 1 a query about the analysis items corresponding to the read sample ID.

[0145] In step S104, the LIS1 displays the query sent in step S302 on the display 16. In one implementation, the query may be displayed as an input screen SC1.

[0146] In step S106, the LIS1 accepts the analysis items and the evaluation information. In one implementation example, the analysis items and the evaluation information are accepted as input to the input screen SC1.

[0147] In step S107, the LIS 1 accepts an instruction to perform analysis. The instruction to perform analysis is accepted, for example, as an operation on an operation button on the input screen SC1.

[0148] In step S108, the LIS 1 transmits an instruction for analysis and a request for evaluation information to the analysis device 3.

[0149] In step S306, the analysis device 3 stores in the memory unit 31 the analysis items and the request for evaluation information included in the analysis instructions transmitted in step S108.

[0150] In step S308, the analysis device 3 executes an analysis based on the analysis items.

[0151] In step S310, the analysis device 3 detects the end of the analysis in the analysis device 3.

[0152] In step S312, the analysis device 3 transmits to the LIS 1 the analysis results and values ​​of the items specified by the evaluation information.

[0153] In step S110, the LIS1 displays the analysis result and the values ​​of the items designated by the evaluation information transmitted in step S312 on the display 16. Display is one form of output.

[0154] In step S112, the LIS1 receives an evaluation of the analysis results.

[0155] In step S114, the LIS1 determines whether the evaluation received in step S112 is “appropriate.” If the LIS1 determines that the evaluation is “appropriate” (YES in step S114), the LIS1 advances control to step S116, and if not (NO in step S114), the LIS1 advances control to step S120 (FIG. 10).

[0156] In step S116, the LIS 1 transmits the analysis results to the HIS 5 as test results.

[0157] In step S508, the HIS 5 displays on the display 56 the test results transmitted in step S116.

[0158] 10, in step S120, the LIS 1 transmits to the analysis device 3 an instruction for reanalysis and a request for evaluation information.

[0159] In step S320, the analysis device 3 stores in the memory unit 31 the reanalysis instruction and the request for evaluation information transmitted in step S120.

[0160] In step S322, the analysis device 3 executes reanalysis based on the reanalysis instruction.

[0161] In step S324, the analyzer 3 detects the end of the reanalysis.

[0162] In step S326, the analyzer 3 transmits to the LIS 1 the analysis results of the reanalysis and the values ​​of the items specified by the evaluation information.

[0163] In step S122, the LIS1 displays on the display 16 the analysis results of the reanalysis and the values ​​of the items specified by the evaluation information transmitted in step S326.

[0164] In step S124, the LIS1 accepts the evaluation of the analysis result of the reanalysis. After that, the LIS1 returns control to step S114. When the evaluation of the analysis result of the reanalysis is accepted, the LIS1 determines in step S114 whether the evaluation of the analysis result of the reanalysis is "appropriate".

[0165] 9 and 10, the LIS1 displays the values ​​of the items specified by the evaluation information in addition to the analysis results. By checking the values ​​displayed by the LIS1, the laboratory technician can evaluate the analysis results without going to the analysis device 3. This can reduce the burden on the laboratory technician to establish and maintain quality management of the analysis in the analysis system 100.

[0166] [Aspects]

[0167] It will be appreciated by those skilled in the art that the exemplary embodiments described above are examples of the following aspects.

[0168] (Item 1) An analysis system according to one embodiment may include an analysis device and a management server that manages analysis in the analysis device. The management server may include an input unit that accepts input of an analysis instruction and analysis evaluation information for each sample, and a first communication interface that transmits the analysis instruction and a request for the evaluation information to the analysis device. The evaluation information may specify at least one item of the content used by the analysis device to derive an analysis result. The analysis device may include an analysis unit that derives an analysis result by analyzing a sample in response to the analysis instruction, and a second communication interface that transmits the analysis result and a value of an item specified by the evaluation information in the content used to derive the analysis result to the management server. The management server may further include an output unit that outputs the analysis result and the value of the item specified by the evaluation information.

[0169] According to the analysis system described in paragraph 1, the evaluation information specifies at least one of one or more items of content used by the analysis device to derive the analysis result. The management server acquires the analysis result and the value of the item specified by the evaluation information from the analysis device. A user of the management server can check the value of the item specified by the evaluation information and evaluate the analysis result. This allows the user to evaluate the analysis result without having to go to the analysis device.

[0170] (Item 2) In the analysis system described in item 1, the at least one item may include analysis conditions and at least one of basic data derived in the analysis unit for the analysis results.

[0171] According to the analytical system described in paragraph 2, the user can confirm analytical conditions and / or basic data as evaluation information when evaluating the analytical results. The analytical conditions and basic data can be directly involved in the derivation of the analytical results. Therefore, the user can evaluate the analytical results using information that can be directly involved in the derivation of the analytical results.

[0172] (Item 3) In the analytical system described in item 2, the analytical conditions may include at least one of reagent information, consumable information, calibration curve information, software used, information used for component identification, pretreatment protocol information, and analytical method information.

[0173] According to the analysis system described in paragraph 3, a user can evaluate the analysis results by utilizing information that may be directly involved in deriving the analysis results.

[0174] (Item 4) In the analysis system according to item 2 or 3, the basic data may include at least one of a mass spectrum and a mass chromatogram obtained for a sample.

[0175] According to the analysis system described in paragraph 4, a user can evaluate the analysis results by utilizing information that may be directly involved in deriving the analysis results.

[0176] (Item 5) The analysis system described in any one of items 1 to 4 may further include an instruction server that transmits an instruction for testing a sample to the management server. The output unit may output the content of the instruction for the test from the instruction server. The input of the instruction for analysis and the information for evaluation may be accepted after the output unit outputs the instruction for the test.

[0177] According to the analysis system described in paragraph 5, a user of the management server can input analysis instructions and evaluation information into the input section based on the contents of instructions from the instruction server.

[0178] (Item 6) In the analysis system described in Item 5, the input unit may receive an evaluation of the analysis results for each sample after the output unit outputs the analysis results and values ​​of items designated as the evaluation information. The first communication interface may transmit the analysis results to the instruction server for samples having appropriate evaluation values.

[0179] According to the analysis system described in section 6, the analysis results are transmitted from the management server to the instruction server on the condition that the analysis results are evaluated as being proper.

[0180] (Item 7) In the analysis system described in item 6, the first communication interface may transmit an instruction to the analysis device to perform reanalysis for a sample having an inappropriate evaluation value.

[0181] According to the analysis system described in paragraph 7, if a certain analysis result is evaluated as being inappropriate, the user can be provided with new analysis results obtained by reanalysis.

[0182] (Item 8) The management server according to one embodiment may be a management server that manages an analysis device that analyzes samples. The management server may include an input unit that accepts input of an analysis instruction and analysis evaluation information for each sample. The evaluation information may specify at least one item of content that the analysis device uses to derive an analysis result. The management server may further include a communication interface that transmits the analysis instruction and a request for the evaluation information to the analysis device, and an output unit that outputs an analysis result according to the analysis instruction transmitted from the analysis device, and a value of an item specified by the evaluation information.

[0183] According to the management server described in paragraph 8, the evaluation information specifies at least one of one or more items of content used by the analysis device to derive the analysis result. The management server acquires the analysis result and the value of the item specified by the evaluation information from the analysis device. A user of the management server can check the value of the item specified by the evaluation information and evaluate the analysis result. This allows the user to evaluate the analysis result without having to go to the analysis device.

[0184] (Section 9) Section 8 Described The management server may be configured such that the at least one item includes at least one of analysis conditions and basic data derived for the analysis result in the analysis device.

[0185] According to the management server described in paragraph 9, the user can confirm the analysis conditions and / or basic data as the evaluation information in evaluating the analysis results. The analysis conditions and basic data may be directly involved in the derivation of the analysis results. Therefore, the user can evaluate the analysis results using information that may be directly involved in the derivation of the analysis results.

[0186] (Item 10) In the management server described in Item 9, the analysis conditions may include at least one of reagent information, consumable information, calibration curve information, software used, information used for component identification, pretreatment protocol information, and analysis method information.

[0187] According to the analysis system described in paragraph 10, a user can evaluate the analysis results by utilizing information that may be directly involved in deriving the analysis results.

[0188] (Item 11) In the management server according to item 9 or 10, the basic data may include at least one of a mass spectrum and a mass chromatogram obtained for a sample.

[0189] According to the analysis system described in paragraph 11, a user can evaluate the analysis results by utilizing information that may be directly involved in deriving the analysis results.

[0190] (Item 12) In the management server described in any one of Items 8 to 11, the communication interface may receive an instruction to test a sample from an instruction server. The output unit may output the contents of the instruction to test from the instruction server. The analysis instruction and the input of the evaluation information may be accepted after the communication interface receives the instruction to test.

[0191] According to the management server described in paragraph 12, a user of the management server can input analysis instructions and evaluation information to the input unit based on the contents of instructions from the instruction server.

[0192] (Item 13) In the management server described in Item 12, the input unit may receive an evaluation of the analysis results for each sample after the output unit outputs values ​​of items designated as the evaluation information. The communication interface may transmit the analysis results to the instruction server for samples having the evaluation value of appropriateness.

[0193] According to the management server described in paragraph 13, the analysis result is transmitted from the management server to the instruction server on the condition that the analysis result is evaluated as being proper.

[0194] (Item 14) In the management server according to item 13, the communication interface may transmit an instruction to the analysis device to perform reanalysis for a sample having an inappropriate evaluation value.

[0195] According to the management server described in paragraph 14, when a certain analysis result is evaluated as being inappropriate, the user can be provided with new analysis results obtained by reanalysis.

[0196] (Item 15) An analytical device according to one embodiment may be an analytical device that analyzes a sample. The analytical device may include a communication interface that receives, for each sample, an analysis instruction and a request for evaluation information for the analysis from a management server. The evaluation information may specify at least one item of content that the analytical device uses to derive an analysis result for the sample. The analytical device may further include an analysis unit that derives an analysis result by analyzing the sample in response to the analysis instruction. The communication interface may transmit the analysis result and a value of the item specified by the evaluation information to the management server.

[0197] According to the analytical device described in paragraph 15, the evaluation information specifies at least one of one or more items of content used by the analytical device to derive the analysis result. The management server acquires the analysis result and the value of the item specified by the evaluation information from the analytical device. A user of the management server can check the value of the item specified by the evaluation information and evaluate the analysis result. This allows the user to evaluate the analysis result without having to go to the analysis device.

[0198] (Item 16) In the analytical device described in item 15, the at least one item may include at least one of analytical conditions and basic data derived in the analytical section for the analysis results.

[0199] According to the analytical device described in paragraph 16, a user can confirm analytical conditions and / or basic data as evaluation information in evaluating an analytical result. The analytical conditions and basic data can be directly involved in deriving an analytical result. Therefore, a user can evaluate an analytical result by using information that can be directly involved in deriving an analytical result.

[0200] (Item 17) In the analytical device described in item 15, the analysis conditions may include at least one of reagent information, consumable information, calibration curve information, software used, information used for component identification, pretreatment protocol information, and analysis method information.

[0201] According to the analysis device described in paragraph 17, a user can evaluate the analysis result by utilizing information that can be directly involved in deriving the analysis result.

[0202] (Item 18) In the analytical device according to item 15, the basic data may include at least one of a mass spectrum and a mass chromatogram acquired for the sample.

[0203] According to the analytical device described in paragraph 18, a user can evaluate the analytical result by utilizing information that can be directly involved in deriving the analytical result.

[0204] (Item 19) A program according to one embodiment may be a program that, when executed by a management server computer, causes the computer to carry out a method for managing analysis results obtained by an analysis device. The method may include a step of accepting input of an analysis instruction and analysis evaluation information for each sample. The evaluation information may specify at least one of contents used by the analysis device to derive an analysis result. The method may further include a step of transmitting the analysis instruction and a request for the evaluation information to an analysis device, and a step of outputting an analysis result according to the analysis instruction and values ​​of items specified by the evaluation information, both transmitted from the analysis device.

[0205] According to the program described in paragraph 19, the evaluation information specifies at least one of one or more items of content used by the analysis device to derive the analysis result. The management server acquires the analysis result and the value of the item specified by the evaluation information from the analysis device. A user of the management server can check the value of the item specified by the evaluation information and evaluate the analysis result. This allows the user to evaluate the analysis result without having to go to the analysis device.

[0206] The embodiments disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present invention is defined by the claims, not the above description, and is intended to include all modifications within the meaning and scope of the claims. [Explanation of symbols]

[0207] 1 LIS, 3 analytical device, 5 HIS, 7A, 7B network, 10, 30, 50 processor, 11, 31, 51 memory unit, 13, 53 interface, 15, 35, 55 communication interface, 16, 36, 56 display, 17, 37, 57 input unit, 32 storage unit, 33 detection unit, 34 pre-processing unit, 38 liquid chromatograph, 39 mass analyzer, 100 analysis system, 110, 310, 510 program storage area, 111, 311, 511 data storage area, 300 control unit, SC1 input screen, SC2 result screen, SC11 to SC14, SC21 to SC24 columns.

Claims

1. An analytical device; a management server for managing the analysis in the analysis device, The management server includes: an input unit for receiving, for each sample, an analysis instruction and input of information for evaluation of the analysis; a first communication interface that transmits the instruction for the analysis and the request for the evaluation information to the analysis device; The evaluation information is information that specifies at least one item of the content used by the analysis device to derive an analysis result, so that a user can evaluate whether the analysis result is appropriate or inappropriate, The analysis device comprises: an analysis unit that analyzes the sample in response to the analysis instruction to derive an analysis result; a second communication interface that transmits the analysis result and a value of an item designated by the evaluation information among the contents used to derive the analysis result to the management server; The management server includes: The analysis system further includes an output unit that outputs the analysis result and the value of the item specified by the evaluation information.

2. The analysis system according to claim 1 , wherein the at least one item includes at least one of an analysis condition and basic data derived for the analysis result in the analysis unit.

3. The analytical system according to claim 2 , wherein the analytical conditions include at least one of reagent information, consumables information, calibration curve information, software used, information used for identifying components, pretreatment protocol information, and analytical method information.

4. The analytical system according to claim 2 or 3, wherein the basic data includes at least one of a mass spectrum and a mass chromatogram acquired for the sample.

5. An instruction server that transmits an instruction for testing a sample to the management server, The output unit outputs the content of the instruction for the inspection from the instruction server, 5. The analysis system according to claim 1, wherein the input of the analysis instruction and the evaluation information is accepted after the output unit outputs the inspection instruction.

6. the input unit receives an evaluation of the analysis results for each sample after the output unit outputs the analysis results and values ​​of items designated as the evaluation information; The analysis system according to claim 5 , wherein the first communication interface transmits the analysis results to the instruction server for samples having suitability as the evaluation value.

7. The analysis system according to claim 6 , wherein the first communication interface transmits an instruction to the analysis device to perform reanalysis for a sample having an unsuitable evaluation value.

8. A management server for managing an analysis device for analyzing a sample, an input unit for receiving, for each sample, an instruction for analysis and input of information for evaluation of the analysis; The evaluation information is information that specifies at least one item of the content used by the analysis device to derive an analysis result, so that a user can evaluate whether the analysis result is appropriate or inappropriate, a communication interface for transmitting the instruction for the analysis and the request for the evaluation information to the analysis device; -face, The management server further comprises an output unit that outputs an analysis result according to the analysis instruction transmitted from the analysis device and a value of an item specified by the evaluation information.

9. The management server according to claim 8 , wherein the at least one item includes at least one of an analysis condition and basic data derived for the analysis result in the analysis device.

10. The management server according to claim 9 , wherein the analysis conditions include at least one of reagent information, consumables information, calibration curve information, software used, information used for component identification, pretreatment protocol information, and analysis method information.

11. 11. The management server according to claim 9, wherein the basic data includes at least one of a mass spectrum and a mass chromatogram acquired for a sample.

12. The communication interface receives an instruction for testing a sample from an instruction server; The output unit outputs the content of the instruction for the inspection from the instruction server, The management server according to any one of claims 8 to 11, wherein the analysis instruction and the evaluation information are input after the communication interface receives the inspection instruction.

13. the input unit receives an evaluation of the analysis result after the output unit outputs values ​​of items designated as the evaluation information for each sample; The management server according to claim 12 , wherein the communication interface transmits the analysis results to the instruction server for samples having suitability as a value of the evaluation.

14. The management server according to claim 13 , wherein the communication interface transmits an instruction to the analysis device to perform reanalysis for a sample having an inappropriate evaluation value.

15. An analytical device for analyzing a sample, comprising: a communication interface for receiving, for each sample, an instruction for analysis and a request for information for evaluation of the analysis from the management server; The evaluation information is information that specifies at least one item of the content used by the analysis device to derive an analysis result of a sample, so that a user can evaluate whether the analysis result is appropriate or inappropriate, An analysis unit that analyzes the sample in response to the analysis instruction to derive an analysis result, The communication interface transmits the analysis result and the value of the item specified by the evaluation information to the management server.

16. The analysis device according to claim 15 , wherein the at least one item includes at least one of an analysis condition and basic data derived for the analysis result in the analysis section.

17. The analytical device according to claim 16 , wherein the analytical conditions include at least one of reagent information, consumables information, calibration curve information, software used, information used for identifying components, pretreatment protocol information, and analytical method information.

18. The analytical device according to claim 16 or 17, wherein the basic data includes at least one of a mass spectrum and a mass chromatogram acquired for the sample.

19. A program that, when executed by a management server computer, causes the computer to perform a method for managing analysis results obtained by an analysis device, comprising: The method comprises: The method includes a step of receiving, for each sample, an instruction for analysis and input of information for evaluation of the analysis; The evaluation information is information for designating at least one of the contents used by the analysis device to derive an analysis result, so that a user can evaluate whether the analysis result is appropriate or inappropriate, The method further comprises: transmitting the instruction for analysis and the request for evaluation information to an analysis device; The program further includes a step of outputting an analysis result according to the analysis instruction transmitted from the analysis device and a value of an item specified by the evaluation information.

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