Composition for topical skin preparation

Abstract

To provide a composition for topical skin preparations that suppresses the odor caused by retinol palmitate, ensures outstanding stability of formulations during storage, and is non-irritating when applied.SOLUTION: A composition for topical skin preparations contains the following components A, B, C and D. The content of component D is 0.25 mass% or more. Component A: nicotinic acid and / or a derivative thereof, component B: retinol and / or a derivative thereof, component C: a nonionic surfactant and component D: δ-tocopherol.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for external skin preparation. [Background technology]

[0002] In recent years, one of the main functions required for skin care preparations is "anti-aging," and various drugs that exert anti-aging effects have been proposed. Among these drugs, nicotinamide and retinol palmitate have attracted attention as ingredients with anti-aging effects, and there have been an increasing number of proposals for techniques that use both ingredients in combination (see, for example, Patent Documents 1 and 2).

[0003] Thus, although there are advantages to using nicotinamide and retinol palmitate in combination to exert an anti-aging effect, retinol palmitate is easily oxidized and decomposed by light and air, and has the disadvantages of causing odor, which deteriorates the storage stability of the preparation, and of making it easy to feel irritation when applied. Therefore, antioxidants are widely used to suppress oxidation by light and air, but there is a problem that the antioxidant effect cannot be fully exerted depending on the type and amount. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent Publication No. 2021-063076 [Patent Document 2] Patent Publication No. 2021-098655 Summary of the Invention [Problem to be solved by the invention]

[0005] Therefore, the present invention has been made in view of the above-mentioned technology, and provides a method for treating retinol palmitate. etc. The present invention aims to provide a composition for external skin preparations which suppresses odors caused by the above-mentioned substances, has significantly excellent storage stability as a preparation, and does not cause irritation when applied. [Means for solving the problem]

[0006] That is, the present invention provides a composition for external skin preparation, comprising the following components A, B, C, and D, wherein the content of component D is 0.25 mass% or more: Component A: Nicotinic acid and / or its derivatives Ingredient B: Retinol and / or its derivatives Component C: Nonionic surfactant Ingredient D: δ-tocopherol

[0007] It is preferable that the content ratio of the component D to the component B (component D / component B) falls within the range of 0.5 to 10.

[0008] Furthermore, it is preferable that the composition contains the following component E. Component E: Carbomer and / or (Acrylates / C10-30 Alkyl Acrylate) Crosspolymer Effect of the Invention

[0009] The composition for external skin preparation of the present invention satisfies the above-mentioned constituent requirements, Retinol palmitate, etc. This has the effect of suppressing the odor caused by the above-mentioned and maintaining the outstanding storage stability of the preparation, while also significantly reducing the irritating sensation when applied. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The composition for external skin preparation of the present invention is characterized in that it contains the following components A, B, C, and D, and the content of component D is 0.25 mass% or more. Component A: Nicotinic acid and / or its derivatives Ingredient B: Retinol and / or its derivatives Component C: Nonionic surfactant Ingredient D: δ-tocopherol

[0011] Hereinafter, each component used in the composition for external skin preparation of the present invention will be described in detail.

[0012] [Component A] The component A is nicotinic acid and / or a derivative thereof. That is, the component A is one or both of nicotinic acid and a nicotinic acid derivative. In the present invention, by using the component A, it is possible to exert an excellent anti-aging effect.

[0013] Specific examples of component A include nicotinic acid, nicotinamide, tocopherol nicotinate, methyl nicotinate, ethyl nicotinate, etc. One type of component A may be used alone, or two or more types may be used in appropriate combination.

[0014] Of the above-mentioned component A, from the viewpoint of exerting a better anti-aging effect, it is preferable to use at least one selected from nicotinic acid, nicotinamide, and tocopherol nicotinate, it is more preferable to use nicotinic acid and / or nicotinamide, and it is most preferable to use nicotinamide.

[0015] In the present invention, a commercially available product may be used as the above-mentioned component A. The commercially available product of the above-mentioned component A may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0016] The content of the above-mentioned component A in the composition for external skin preparation of the present invention is not particularly limited as long as it can exert the desired effect, but from the viewpoint of exerting a good anti-aging effect, it is preferably 1% by mass to 10% by mass, more preferably 3% by mass to 7% by mass, based on 100% by mass of the composition. Note that the content of the above-mentioned component A is the amount converted into a pure content.

[0017] [Component B] The component B is retinol and / or a derivative thereof. That is, the component B is one or both of retinol and a retinoic acid derivative. In the present invention, by using the component B, it is possible to exert an excellent anti-aging effect.

[0018] Specific examples of component B include retinol, retinol palmitate, hydrogenated retinol, retinol acetate, retinol propionate, and retinol linoleate. These components B may be used alone or in appropriate combination of two or more.

[0019] Of the above-mentioned component B, from the viewpoint of exerting a better anti-aging effect, it is preferable to use at least one selected from retinol, retinol palmitate, and hydrogenated retinol, it is more preferable to use retinol and / or retinol palmitate, and it is most preferable to use retinol palmitate.

[0020] In the present invention, a commercially available product may be used as the component B. The commercially available product of the component B may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0021] The content of the above-mentioned component B in the composition for external skin preparation of the present invention is not particularly limited as long as it can exert the desired effect, but from the viewpoint of exerting a good anti-aging effect, it is preferably 0.001% by mass to 1% by mass, more preferably 0.01% by mass to 0.5% by mass, in 100% by mass of the composition. Note that the content of the above-mentioned component B is the amount converted into a pure content.

[0022] [Component C] The component C is a nonionic surfactant. In the present invention, by using the component C, the components A and B can be stably blended in the composition.

[0023] Examples of the component C include glycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acids, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene hydrogenated castor oil, etc. One type of these components C may be used alone, or two or more types may be used in appropriate combination.

[0024] Of the above component C, from the viewpoint of blending the above components A and B more stably, it is preferable to use at least one selected from glycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyglycerin fatty acid esters, and it is more preferable to use at least one selected from glycerin fatty acid esters, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters.

[0025] In the present invention, a commercially available product may be used as the component C. The commercially available product of the component C may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0026] The content of the above-mentioned component C in the composition for external skin preparation of the present invention is not particularly limited as long as it can exert the desired effect, but it is preferably 0.5% by mass to 5% by mass, and more preferably 1% by mass to 3% by mass, based on 100% by mass of the composition, from the viewpoint of more stable blending of the above-mentioned components A and B. The content of the above-mentioned component C is the amount converted into a pure content.

[0027] [Component D] The component D is δ-tocopherol. By using the component D, the oxidative decomposition of the component B is suppressed, and thus odor deterioration is suppressed, the storage stability of the preparation is maintained, and the irritation during application is significantly suppressed. In the present invention, the component D exhibits a significantly superior effect to other structurally similar components such as α-tocopherol, β-tocopherol, and γ-tocopherol.

[0028] In the present invention, a commercially available product may be used as the above-mentioned component D. The commercially available product of the above-mentioned component D may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0029] The content of the above-mentioned component D in the composition for external skin preparation of the present invention is not particularly limited as long as it can exert the desired effect, but from the viewpoint of suppressing the odor caused by the above-mentioned component B, maintaining the storage stability of the preparation, and suppressing irritation during application, it is preferably 0.25% by mass to 0.8% by mass, and more preferably 0.3% by mass to 0.6% by mass, based on 100% by mass of the composition. The content of the above-mentioned component D is the amount converted into a pure content.

[0030] In the present invention, from the viewpoint of suppressing the odor caused by the component B, further enhancing the storage stability of the preparation, and significantly reducing the irritating sensation upon application, the content ratio of the component D to the component B, "component D / component B," is preferably prepared to satisfy the range of 0.5 to 10, and more preferably to satisfy the range of 1 to 7.

[0031] [Component E] The composition for external skin preparation of the present invention preferably further contains a carboxyvinyl polymer and / or an (acrylates / alkyl acrylate (C10-30)) crosspolymer as component E. In the present invention, by using the above-mentioned component E, it is possible to further improve skin compatibility and spreadability upon application.

[0032] The above-mentioned component E is usually neutralized with a basic substance before use. Examples of the basic substance include alkanolamines such as triethanolamine and monoethanolamine; inorganic bases such as ammonia, sodium hydroxide, and potassium hydroxide; and basic amino acids such as arginine. The amount of the basic substance added is an amount sufficient to neutralize the above-mentioned component E, and may be appropriately blended depending on the type and amount of these components used.

[0033] In the present invention, a commercially available product may be used as the above-mentioned component E. The commercially available product of the above-mentioned component E may be a single raw material or a mixed raw material with other components, and is not particularly limited as long as the desired effect is exhibited.

[0034] The content of the above-mentioned component E in the composition for external skin preparation of the present invention is not particularly limited as long as it can exert the desired effect, but from the viewpoint of further improving skin compatibility and spreadability upon application, it is preferably 0.01% by mass to 1% by mass, more preferably 0.1% by mass to 0.8% by mass, based on 100% by mass of the composition. The content of the above-mentioned component E is the amount converted into a pure content.

[0035] [Other ingredients] In addition to the above-mentioned components, the composition for external skin preparation of the present invention may contain, as appropriate depending on the purpose, active ingredients other than the above-mentioned components A and B, surfactants other than the above-mentioned component C, oils, thickeners other than the above-mentioned component E, polyhydric alcohols, ultraviolet absorbers, fragrances, pH adjusters, film-forming agents, chelating agents, lower alcohols, astringents, antioxidants other than the above-mentioned component D, preservatives, colorants, plant extracts, plant fermentation extracts, purified water, and the like.

[0036] The dosage form of the composition for external skin preparation of the present invention is not particularly limited as long as it can exert the desired effect, and it can be prepared into various dosage forms such as liquid, gel, emulsion, cream, etc. In the present invention, from the viewpoint of exerting a significantly excellent storage stability of the preparation and from the viewpoint of usability, it is preferable to prepare it into a gel, emulsion, or cream, and among them, it is more preferable to prepare it into an emulsion form such as an emulsion or cream.

[0037] The method for producing the composition for external skin preparation of the present invention is not particularly limited, but may be, for example, a known method.Specifically, for example, the above-mentioned components are mixed and stirred using a disper mixer, homomixer, disper mill, etc., but the present invention is not limited to these methods.

[0038] The area to which the composition for topical skin preparation according to one embodiment of the present invention is applied is not particularly limited, but examples include the face (forehead, eyes, corners of the eyes, cheeks, mouth, etc.), arms, elbows, backs of the hands, fingertips, feet, knees, heels, neck, décolleté, armpits, and back. EXAMPLES

[0039] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples. The blend amounts are expressed in "mass %" unless otherwise specified.

[0040] (Sample preparation 1) According to the compositions shown in Tables 1 and 2, the compositions for external skin preparations of Examples 1 to 5 and Comparative Examples 1 to 3 were prepared into cream formulations in a standard manner and subjected to the following evaluations. The results are shown in Tables 1 and 2. The amounts of ingredients in the tables are all values ​​converted to pure contents.

[0041] (Test Example 1: Storage stability of the formulation) Each sample obtained in the Examples and Comparative Examples was filled into a 50 mL glass mayonnaise bottle, which was then stored in a thermostatic chamber at 40° C. for 4 weeks, after which the presence or absence of an "unpleasant odor" was confirmed.

[0042] The presence or absence of an unpleasant odor was evaluated by smelling each sample directly from the mouth of the mayonnaise bottle to confirm whether or not there was an odor of rancidity, and the odor was evaluated according to the following criteria.

[0043] <Evaluation criteria for the presence or absence of strange odors> ○ (Good): No strange odors detected △ (poor): A slight rancid smell is detectable × (bad): The smell of rancidity is clearly detectable.

[0044] (Test Example 2: Evaluation upon application) A usage test was carried out by applying 0.1 g of each sample obtained in the Examples and Comparative Examples to the back of the hand, and a sensory evaluation was carried out on the "sensation of irritation" during application, and the results were scored according to the following evaluation points of 1 to 5. Each evaluation was carried out by five expert evaluators, and the average score was calculated from the evaluation results of each evaluator and determined according to the following judgment criteria. In addition, the evaluation of "sensation of irritation" was given a higher score when the irritation was not tingly or burning.

[0045] <Evaluation criteria> 5 points: Very good 4 points: Good 3 points: normal 2 points: Defective 1 point: Very poor

[0046] <Judgment criteria> ◎: Average 4.0 points or more ○: Average 3.0 points or more and less than 4.0 points △: Average 2.0 points or more and less than 3.0 points ×: Average score below 2.0

[0047] [Table 1]

[0048] [Table 2]

[0049] From the results shown in Tables 1 and 2, it can be seen that the compositions for external preparations for skin of the present invention obtained in each Example do not show any odor caused by the above-mentioned component B, and the storage stability of the preparation is maintained, compared with those obtained in each Comparative Example. It can also be seen that the compositions are safe and do not cause irritation when applied. In other words, it can be said that the compositions for external preparations for skin of the present invention can fully exert a significantly superior effect by satisfying the above-mentioned constituent requirements.

Claims

1. Component A: 1 to 10% by mass of nicotinamide, Component B: retinol and / or its derivatives 0.001 to 1% by mass, Component C: 0.5 to 5% by mass of a nonionic surfactant, and Component D: δ-tocopherol 0.25 to 0.8% by mass The composition comprises As the retinol and / or its derivative, at least one component selected from the group consisting of retinol palmitate, retinol acetate, retinol propionate, and retinol linoleate is used, A composition for external skin preparation, characterized in that the content ratio of component D to component B (component D / component B) falls within the range of 0.5 to 10.

2. Component E: 0.01% by mass to 1% by mass of carboxyvinyl polymer and / or (acrylates / alkyl acrylate (C10-30)) crosspolymer The composition for external skin preparation according to claim 1, further comprising:

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