Saliva-soluble dental adhesive sheet

Abstract

To provide a saliva-soluble tooth sticker sheet that sufficiently exhibits the effects of an acid such as phytic acid or a salt thereof and can effectively prevent stains from depositing on teeth.SOLUTION: A saliva-soluble tooth sticker sheet has a sticking layer (X) having a face to be stuck to a tooth or its surroundings. The sticking layer (X) contains phytic acid or a salt thereof (a), and a water-soluble polymer (b). The mass ratio between the content of component (a) and the total moisture content in the saliva-soluble tooth sticker sheet [(a) / moisture content] is 0.3-6. The mass ratio between the content of component (b) and the content of component (a) in the saliva-soluble tooth sticker sheet [(a) / (b)] is 1.1-12. The mass of the component (a) per unit area of the saliva-soluble tooth sticker sheet is 0.3-13 mg / cm2.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a saliva-soluble dental patch. [Background technology]

[0002] In addition to tartar and plaque, various stains accumulate on the surface of human teeth due to habitual consumption of tea and coffee, smoking, aging, etc. If these stains are left untreated, the teeth will lose their original healthy color and shine, and may even cause oral diseases. For this reason, various developments have been made.

[0003] For example, Patent Document 1 discloses an oral composition containing phytic acid or its salt and tripolyphosphoric acid or its salt in a specific total content and mass ratio, which is an attempt to achieve both a stain-removing effect and an adhesion-preventing effect on stain deposits. Patent Document 2 discloses a dental patch sheet having a layer (A) with a specific pH value and a layer (B) containing phytic acid, hexametaphosphoric acid, etc. and with a specific pH value, which enhances the tooth whitening effect by removing minute solid products adhering to the tooth surface. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2018-65801 A [Patent Document 2] International Publication No. 2014 / 069595 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the oral composition described in Patent Document 1, which is in the form of mouthwash, dentifrice, etc., does not fully exhibit the effect of preventing the adhesion of stains, and there is still room for further study. Also, the dental patch sheet described in Patent Document 2 has insufficient conformability and adhesion to the application site, and further improvement is required to allow the acid such as phytic acid or its salt to act sufficiently on the application site.

[0006] That is, the present invention relates to a saliva-soluble dental patch sheet which allows an acid such as phytic acid or a salt thereof to act sufficiently and exhibits an excellent effect of preventing the adhesion of stains deposited on teeth. [Means for solving the problem]

[0007] The present inventors have conducted various studies and have found that a saliva-soluble dental patch sheet which is provided with an adhesive layer having a surface to be applied to the teeth or the area surrounding the teeth, in which the total moisture content of the sheet has a specific quantitative relationship with the acid such as phytic acid or a salt thereof and the water-soluble polymer contained in said adhesive layer, and which contains a specific amount of the acid such as phytic acid or a salt thereof per fixed area of ​​the sheet, can satisfactorily embed the acid such as phytic acid or a salt thereof within the sheet, and as the sheet dissolves in saliva after application, the acid such as phytic acid or a salt thereof is continuously released to the application site while remaining in the area surrounding the teeth, thereby allowing the acid such as phytic acid or a salt thereof to act efficiently and effectively on the application site.

[0008] Therefore, the present invention provides a saliva-soluble dental patch sheet having an adhesive layer (X) having a surface to be applied to teeth or the area surrounding the teeth, The patch layer (X) contains phytic acid or a salt thereof (a) and a water-soluble polymer (b), the mass ratio ((a) / moisture) of the content of component (a) to the total moisture content in the saliva-soluble dental patch sheet is 0.3 to 6; the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the saliva-soluble dental patch sheet is 1.1 to 12; and The mass of component (a) per unit area of ​​the saliva-soluble dental adhesive sheet is 0.3 to 13 mg / cm 2 The present invention provides a saliva-soluble dental patch sheet comprising:

[0009] Another aspect of the present invention is a saliva-soluble dental patch sheet having an adhesive layer (X) having a surface to be applied to teeth or the area surrounding the teeth, The patch layer (X) contains one or more acids or salts thereof (a') selected from malic acid, acetic acid, lactic acid, tartaric acid, citric acid, glycolic acid, succinic acid, and salts thereof, and a water-soluble polymer (b); the mass ratio ((a) / moisture) of the content of component (a') to the total moisture content in the saliva-soluble dental patch sheet is 0.025 to 6; the mass ratio ((b) / (a')) of the content of component (b) to the content of component (a') in the saliva-soluble dental patch sheet is 1.1 to 12; and The mass of component (a') per unit area of ​​the saliva-soluble dental adhesive sheet is 0.3 to 13 mg / cm 2 The present invention provides a saliva-soluble dental patch sheet comprising: Effect of the Invention

[0010] According to the saliva-soluble dental patch sheet of the present invention, since the sheet itself has excellent flexibility, it is possible to exhibit high conformability and adhesion to the teeth or the area surrounding the teeth while satisfactorily embedding an acid such as phytic acid or its salt within the sheet. Therefore, when applied to the teeth or the area surrounding the teeth, as the saliva-soluble dental patch sheet of the present invention dissolves in saliva while remaining satisfactorily adhered to the teeth or the area surrounding the teeth, the embedded acid such as phytic acid or its salt can be continuously released, retained and acted on the application site, thereby providing an excellent effect of preventing the adhesion of deposited stains. Furthermore, even while the saliva-soluble dental patch sheet of the present invention is being applied to the teeth or the areas surrounding the teeth, any sense of incongruity or discomfort is effectively reduced, so that a comfortable sensation can be maintained while the sheet is completely dissolved in the oral cavity and while the acid such as phytic acid or its salt is fully acting. [Brief description of the drawings]

[0011] [Figure 1] 1 is a photograph of the sheet of Example 1 taken for image analysis using Photoshop in evaluating the effect of inhibiting adhesion of dirt deposits. [Diagram 2] 1 is a photograph of the sheet of Comparative Example 1 taken for image analysis using Photoshop in the evaluation of the effect of inhibiting the adhesion of dirt deposits. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] The present invention will be described in detail below. The saliva-soluble dental patch sheet of the present invention is a saliva-soluble dental patch sheet comprising an adhesive layer (X) having a surface to be applied to teeth or the area surrounding teeth, The patch layer (X) contains phytic acid or a salt thereof (a) and a water-soluble polymer (b), the mass ratio ((a) / moisture) of the content of component (a) to the total moisture content in the saliva-soluble dental patch sheet is 0.3 to 6; the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the saliva-soluble dental patch sheet is 1.1 to 12; and The mass of component (a) per unit area of ​​the saliva-soluble dental adhesive sheet is 0.3 to 13 mg / cm 2 It is. In another embodiment of the saliva-soluble dental patch sheet of the present invention, there is provided a saliva-soluble dental patch sheet having an adhesive layer (X) having a surface to be applied to teeth or the area surrounding the teeth, The patch layer (X) contains one or more acids or salts thereof (a') selected from malic acid, acetic acid, lactic acid, tartaric acid, citric acid, glycolic acid, succinic acid, and salts thereof, and a water-soluble polymer (b); the mass ratio ((a) / moisture) of the content of component (a') to the total moisture content in the saliva-soluble dental patch sheet is 0.025 to 6; the mass ratio ((b) / (a')) of the content of component (b) to the content of component (a') in the saliva-soluble dental patch sheet is 1.1 to 12; and The mass of component (a') per unit area of ​​the saliva-soluble dental adhesive sheet is 0.3 to 13 mg / cm 2 It is.

[0013] In this specification, phytic acid or its salt contained in the patch layer (X) is referred to as component (a), and one or more acids or their salts selected from malic acid, acetic acid, lactic acid, tartaric acid, citric acid, glycolic acid, succinic acid, and their salts are referred to as component (a'). Furthermore, these phytic acids or their salts, as well as one or more acids or their salts selected from malic acid, acetic acid, lactic acid, tartaric acid, citric acid, glycolic acid, succinic acid, and their salts are collectively referred to as phytic acid or other acids or their salts ((a) or (a')).

[0014] That is, the saliva-soluble dental patch sheet of the present invention has an adhesive layer (X) having a surface to be applied to teeth or the area surrounding teeth, and the adhesive layer (X) contains an acid such as phytic acid or its salt (a) or (a') and a water-soluble polymer (b). The total water content contained in the saliva-soluble dental patch sheet of the present invention maintains the above-mentioned specific mass ratio ((a) or (a') / water) between the content of the acid such as phytic acid or its salt (a) or (a') in the saliva-soluble dental patch sheet, and the content of the component (b) also maintains a specific mass ratio ((b) / (a) or (b) / (a')) between the content of the component (a) or (a'). Furthermore, the saliva-soluble dental patch sheet contains a specific amount of an acid such as phytic acid or its salt (a) or (a') per unit area of ​​the saliva-soluble dental patch sheet. This allows the sheet to have excellent conformability and exhibit high adhesion to teeth, etc., while ensuring an appropriate amount of acid such as phytic acid or its salt (a) or (a'), and therefore allows the acid such as phytic acid or its salt (a) or (a') to fully exert its effect of preventing the adhesion of stains due to deposition thereon.

[0015] Here, the area around the teeth means the organs in the oral cavity located around the teeth, including the gums, and the saliva-soluble dental patch sheet of the present invention is a sheet that is applied only to the teeth, only to the area around the teeth, or to both the teeth and the area around the teeth. Hereinafter, "teeth or the area around the teeth" will be collectively referred to as "teeth, etc.", and the saliva-soluble dental patch sheet of the present invention will also be abbreviated to "sheet." In addition, a saliva-soluble dental patch sheet means a sheet that has the property that, when such a sheet comes into contact with saliva, at least a portion of the patch layer (X) is dissolved by the saliva, and the strain at a tensile stress of 20 MPa in the saliva-soluble dental patch sheet increases, thereby increasing flexibility. The mass of each component other than the stock solution used to produce the saliva-soluble dental patch sheet of the present invention is the mass (dry mass) after drying treatment (in the form of the product).

[0016] The saliva-soluble dental patch sheet of the present invention comprises an adhesive layer (X) containing an acid such as phytic acid or its salt (a) or (a') and a water-soluble polymer (b) as a layer having a surface to be attached to teeth, etc. Such a saliva-soluble dental patch sheet is used by directly attaching the surface of the adhesive layer (X) to teeth, etc., and when attached to teeth, etc., the adhesive layer (X) has the property of gradually dissolving in saliva while adhering well to the teeth, etc.

[0017] The patch layer (X) of the saliva-soluble dental patch sheet of the present invention contains, as component (a), phytic acid or a salt thereof. Also, as component (a'), it contains one or more acids or salts thereof selected from malic acid, acetic acid, lactic acid, tartaric acid, citric acid, glycolic acid, succinic acid, and salts thereof. The presence of such component (a) or component (a') in the saliva-soluble dental patch sheet of the present invention can fully exert the effect of preventing the adhesion of deposited stains. Phytic acid is a phosphate compound also known as myo-inositol hexaphosphate. Examples of phytic acid salts include alkali metal salts such as sodium and potassium salts, and ammonium salts.

[0018] The mass ratio of the content of component (a) to the total moisture content ((a) / moisture) in the saliva-soluble dental patch sheet of the present invention is 0.3 to 6, preferably 0.45 to 4, more preferably 0.6 to 3, and even more preferably 0.8 to 2, from the viewpoint of ensuring the conformability of the sheet, satisfactorily embedding component (a) within the sheet, continuously releasing component (a) as the sheet dissolves, and allowing component (a) to remain on or around the teeth. The mass ratio of the content of component (a') to the total moisture content in the saliva-soluble dental patch sheet of the present invention ((a') / moisture) is 0.025 to 6, preferably 0.3 to 6, more preferably 0.45 to 4, even more preferably 0.6 to 3, and even more preferably 0.8 to 2, from the viewpoint of ensuring the conformability of the sheet, satisfactorily embedding component (a') within the sheet, continuously releasing component (a') as the sheet dissolves, and allowing component (a') to remain on the teeth or around the teeth. The content of an acid such as phytic acid or a salt thereof in component (a) or component (a') means the value calculated as the amount of acid.

[0019] The total moisture content of the saliva-soluble dental patch sheet refers to the total amount of moisture contained in all layers of the saliva-soluble dental patch sheet of the present invention, including the adhesive layer (X), i.e., in the entire saliva-soluble dental patch sheet in its entirety after drying treatment (product form), and refers to the value obtained based on a measurement method using a moisture meter utilizing the Karl Fischer method (e.g., Hiranuma Automatic Moisture Measuring Apparatus AQV-300 series). Specifically, the total moisture content of the saliva-soluble dental patch sheet is preferably 3 to 20% by mass, more preferably 7 to 15% by mass, and even more preferably 9 to 14% by mass, based on 100% by mass of the saliva-soluble dental patch sheet.

[0020] The saliva-soluble dental adhesive sheet of the present invention has a unit area (1 cm 2 The mass of component (a) per unit area is 0.3 to 13 mg / cm from the viewpoint of ensuring an appropriate amount of component (a) to act in the oral cavity in order to exert an excellent effect of preventing the adhesion of stains throughout the application of the saliva-soluble dental patch sheet of the present invention.2 and preferably 0.4 to 9.2 mg / cm 2 and more preferably 0.68 to 5.6 mg / cm 2 and more preferably 1 to 1.6 mg / cm 2 It is. The saliva-soluble dental adhesive sheet of the present invention has a unit area (1 cm 2 The mass of component (a') per unit area is 0.3 to 13 mg / cm from the viewpoint of ensuring an appropriate amount of component (a') to act in the oral cavity in order to exert an excellent effect of preventing the adhesion of stains throughout the application of the saliva-soluble dental patch sheet of the present invention. 2 and preferably 0.4 to 9.2 mg / cm 2 and more preferably 0.68 to 5.6 mg / cm 2 and more preferably 1 to 1.6 mg / cm 2 It is. The mass of the component (a) or (a') phytic acid or a salt thereof means the value calculated as the acid.

[0021] The content of component (a) in the saliva-soluble dental patch sheet is preferably 3 to 35 mass %, more preferably 8 to 22 mass %, and even more preferably 11 to 14 mass %, calculated as the acid content, from the viewpoint of fully achieving an excellent effect of preventing the adhesion of stains and efficiently exerting this effect. In order to fully achieve excellent stain-deposition prevention effects and to efficiently exert these effects, the content of component (a') in the saliva-soluble dental patch sheet is preferably 0.5 to 35 mass %, more preferably 3 to 35 mass %, even more preferably 8 to 22 mass %, and even more preferably 11 to 14 mass %, calculated as the acid content.

[0022] The adhesive layer (X) of the saliva-soluble dental patch sheet of the present invention contains a water-soluble polymer as component (b). The inclusion of component (b) allows the sheet to exhibit good solubility in saliva while providing conformability and adhesion to the unevenness of the surface of teeth, etc., and in the saliva-soluble dental patch sheet of the present invention, the mass ratio ((b) / (a)) or mass ratio ((b) / (a')) described below, as well as the above-mentioned mass ratio ((a) / water) or mass ratio ((a') / water), exhibit specific values, thereby further enhancing the conformability of the sheet and exhibiting better adhesion, and the component (a) present in a predetermined amount in the sheet allows the sheet to exhibit a sufficient effect of preventing the adhesion of deposited dirt.

[0023] From the viewpoint of ensuring good solubility in saliva and enhancing conformability and adhesion to teeth, etc., component (b) is preferably a water-soluble polymer having a solubility in water at 20°C of 10% by mass or more, i.e., a water-soluble polymer having a solubility of 10% by mass or more in 100% by mass of saturated aqueous solution at 20°C.

[0024] More specifically, such component (b) includes starch hydrolysates or starch derivatives such as pullulan, dextrin, soluble starch, hydroxyalkyl starch, and starch acetate; Cellulose derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose; Examples of the suitable natural polymers include gelatin, agar, pectin, xanthan gum, locust bean gum, gellan gum, tragacanth gum, gum arabic, glucomannan, guar gum, HP guar gum, and tuberose polysaccharide, and the like, and may include one or more natural polymers or derivatives thereof. Among these, from the viewpoints of ensuring excellent conformability of the sheet and retention of component (a) or component (a') around the teeth while satisfactorily embedding component (a) or component (a') in the sheet when the sheet contains an amount of moisture that satisfies the above-mentioned mass ratio ((a) / moisture) or mass ratio ((a') / moisture), one or more selected from pullulan, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, guar gum, gelatin, tamarind gum, pectin, gum arabic, xanthan gum, tragacanth gum, locust bean gum, dextrin, dextran, agar, starch, carboxymethyl cellulose, methyl cellulose, and hydroxyethyl cellulose are preferred, and pullulan is more preferred.

[0025] The mass ratio ((b) / (a)) or ((b) / (a')) of the content of component (b) to the content of component (a) or component (a') in the saliva-soluble dental patch sheet of the present invention is 1.1 to 12, preferably 1.5 to 10, more preferably 2.5 to 8, even more preferably 3 to 7, and even more preferably 3.5 to 5, from the viewpoints of ensuring excellent conformability of the sheet to satisfactorily embed component (a) or component (a') in the sheet, while enabling sustained release of component (a) or component (a') due to good adhesion of the sheet and allowing it to be satisfactorily retained around the teeth.

[0026] The content of component (b) in the saliva-soluble dental patch sheet is preferably 30 to 60% by mass, more preferably 38 to 56% by mass, even more preferably 42 to 54% by mass, and even more preferably 45 to 53% by mass, from the viewpoint of ensuring excellent conformability of the sheet while efficiently and fully exerting the effect of preventing the adhesion of stains.

[0027] The adhesive layer (X) of the saliva-soluble dental adhesive sheet of the present invention preferably further contains a nonionic surfactant (c) from the viewpoints of enhancing the dispersibility and diffusibility of component (a) or component (a') and component (b), imparting good flexibility to the sheet, and allowing the action of component (a) or component (a') to be fully exerted over the entire surface to be applied to the teeth or the area surrounding the teeth. Examples of such nonionic surfactants (c) include one or more selected from polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene polyoxypropylene copolymers, sucrose fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitol fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene glycol fatty acid esters, polyoxyethylene phytosterols and phytostanols, polyoxyethylene lanolin and lanolin alcohols, polyoxyethylene alkylamines and fatty acid amides, polyoxyethylene alkylphenyl formaldehyde condensates, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene alkylphenyl ethers and fatty acid ethanolamides. Among these, one or two selected from polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene sorbitan fatty acid ester are preferred, it is more preferred to contain one of polyoxyethylene hydrogenated castor oil and polyglycerin fatty acid ester, and it is even more preferred to contain both polyoxyethylene hydrogenated castor oil and polyglycerin fatty acid ester.

[0028] The content of such nonionic surfactant (c) in the saliva-soluble dental patch sheet is preferably 1 to 20% by mass, more preferably 2 to 10% by mass, and even more preferably 3 to 5% by mass, from the viewpoint of imparting good flexibility to the sheet and from the viewpoint of fully exerting the effects of component (a) or component (a').

[0029] It is preferable that the adhesive layer (X) of the saliva-soluble dental adhesive sheet of the present invention contains a limited amount of condensed phosphoric acid, so that the acid such as phytic acid or its salt is continuously released to the application site as the sheet dissolves in saliva after application and is retained around the teeth, thereby allowing the acid such as phytic acid or its salt to fully exert its effect. Specific examples of such condensed phosphoric acids include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid, and cyclic polyphosphoric acids such as trimetaphosphoric acid and tetrametaphosphoric acid, and examples of their salts include sodium salts and potassium salts. In order to fully exert an excellent effect of preventing the adhesion of stains, the content of condensed phosphoric acid or a salt thereof in the saliva-soluble dental patch sheet is less than 0.05% by mass, preferably 0.03% by mass or less, and more preferably 0.01% by mass or less, or it is preferable that the patch layer (X) is substantially free of condensed phosphoric acid or a salt thereof.

[0030] The moisture content of the saliva-soluble dental patch sheet of the present invention is preferably 1 to 25% by mass, more preferably 3 to 20% by mass, and even more preferably 7 to 18% by mass, in order to ensure the total moisture content of the saliva-soluble dental patch sheet and maintain the above-mentioned mass ratio ((a) / moisture) or mass ratio ((a') / moisture) within a specified range.

[0031] The adhesive layer (X) of the saliva-soluble dental adhesive sheet of the present invention may contain, in addition to the above-mentioned components, other components than those mentioned above, so long as the effects of the present invention are not impaired, such as medicinal ingredients other than component (a) or component (a'), such as glycyrrhizinic acid, glycyrrhetinic acid and salts thereof, potassium nitrate, fluorine, etc.; surfactants other than the above-mentioned nonionic surfactants; fragrances; pH adjusters such as sodium hydroxide; humectants such as glycerin; sweeteners such as sodium saccharin and sucralol; colorants; preservatives, etc.

[0032] The surface area of ​​the adhesive layer (X) to be applied to the teeth or the area surrounding the teeth is preferably 5 to 45 cm2 from the viewpoint of ensuring an appropriate amount of component (a) or component (a') to be active in the oral cavity in order to exert an excellent effect of preventing the adhesion of stains. 2 and more preferably 10 to 35 cm 2 and more preferably 15 to 25 cm 2 It is.

[0033] The thickness of the adhesive layer (X) of the saliva-soluble dental adhesive sheet of the present invention is preferably 20 to 500 μm, more preferably 40 to 300 μm, and even more preferably 60 to 70 μm, from the viewpoints of ensuring excellent conformability and increasing adhesion to teeth, enabling sustained release and retention of component (a) or component (a'), and fully exerting the effect of preventing the adhesion of stain deposits.

[0034] The saliva-soluble dental patch sheet of the present invention can have a protective layer (Y) that is less soluble in saliva than the patch layer (X) on the surface opposite to the surface of the patch layer (X) that is to be applied to teeth or the area surrounding the teeth. This can improve the ease of handling of the saliva-soluble dental patch sheet of the present invention. In addition, when the saliva-soluble dental patch sheet of the present invention is applied to teeth, etc., the protective layer (Y) that is less soluble in saliva than the patch layer (X) covers and protects the patch layer (X) that dissolves in saliva first, and enables the sustained release and retention of component (a) or component (a') as the sheet dissolves.

[0035] From the viewpoint of lowering the solubility in saliva than the adhesive layer (X), the protective layer (Y) preferably contains one or more water-insoluble polymers selected from ethyl cellulose, hydroxypropyl methylcellulose acetate succinate, cellulose acetate phthalate, hypromellose phthalate, shellac, polyvinyl acetate, polymethyl methacrylate, methacryloylethyl betaine / methacrylate copolymer, methacrylic acid copolymer, aminoalkyl methacrylate copolymer, and agar. Among them, from the viewpoint of effectively reducing the sense of incongruity and discomfort during application to teeth or the area around teeth while ensuring good flexibility of the saliva-soluble dental adhesive sheet of the present invention, one or two selected from ethyl cellulose and shellac are preferred, and ethyl cellulose is more preferred.

[0036] From the viewpoint of ensuring good flexibility of the saliva-soluble dental patch sheet of the present invention, the thickness of the protective layer (Y) is preferably 0.4 to 10 μm, more preferably 0.6 to 5 μm, and even more preferably 0.8 to 1.6 μm.

[0037] The saliva-soluble dental patch sheet of the present invention can further comprise an intermediate layer (M) formed between the patch layer (X) and the protective layer (Y) in addition to the above-mentioned patch layer (X) and protective layer (Y). This makes it possible, for example, to gradually release component (a) or component (a') from the patch layer (X) and have it remain around the teeth, and subsequently release the desired component contained in the intermediate layer (M) into the oral cavity, and also makes it easy to impart gradual and continuous solubility. Examples of the desired component contained in the intermediate layer (M) include medicinal components such as glycyrrhizinic acid, glycyrrhetinic acid and salts thereof, potassium nitrate, and fluorine. As the material for such intermediate layer (M), the same water-soluble polymer (b) as that for the patch layer (X) can be used.

[0038] In order to exhibit excellent conformability when applied to various irregularities of various sizes that may exist on the surface of teeth, etc., the saliva-soluble dental patch sheet of the present invention has a strain at a tensile stress of 20 MPa of preferably 2% or more, more preferably 3% or more, and even more preferably 4% or more. The strain herein means a value obtained based on the results of measuring the strain against a tensile stress of 20 MPa using a rheometer. In measuring the strain, a universal extension measurement system (UXF12 / UNI) is used as the measurement jig, a rheometer (Anton Paar, MCR502) is used to measure the strain, and Rheoplus32 is used as the analysis software. Specifically, the sheet to be measured is set on the measuring jig, and the measurement time is 30 seconds at room temperature (approximately 25°C), the tensile stress is linearly controlled at 1 point / second to vary from 1 to 20 MPa, and the strain is measured. The amount of change from the initial length of the sheet sandwiched between the rotating drum and the fixed drum is expressed as a percentage, which is the value of the strain relative to a tensile stress of 20 MPa.

[0039] The sheet thickness (total thickness) of the saliva-soluble dental patch sheet of the present invention is preferably such that the strain at a tensile stress of 20 MPa exhibits the above-mentioned value, and from the viewpoint of ensuring excellent conformability and effectively enhancing adhesion to teeth, etc., the sheet thickness is preferably 20 to 500 μm, more preferably 40 to 300 μm, and even more preferably 60 to 70 μm. In the present invention, the "sheet thickness of the saliva-soluble dental patch sheet" means the "average thickness of the entire sheet", specifically, the thickness is measured at 3 to 5 points using a microgauge and the average value calculated from these measurements.

[0040] The saliva-soluble dental patch sheet of the present invention may be produced by laminating a single layer of the patch layer (X) and, if necessary, the protective layer (Y) and / or intermediate layer (M) in a conventional manner, or by laminating them on a substrate in order. All of these layers can be formed by forming them into layers using a stock solution containing the desired components, followed by a drying step and a pressure bonding step.

[0041] It is preferable to provide a release layer (Z) on the surface of the adhesive layer (X) to be applied to teeth, etc., and to laminate the release layer (Z) and the saliva-soluble dental adhesive sheet of the present invention to form a sheet. When using the sheet, the release layer (Z) is peeled off to expose the adhesive layer (X), and the sheet is applied so that the surface to be applied to teeth, etc. comes into contact with the teeth, etc. As a result, when producing the saliva-soluble dental patch sheet of the present invention, the release layer (Z) can be used as a substrate, and the patch layer (X), protective layer (Y), etc. can be sequentially supported and laminated. In addition, from the time of production of the sheet until the time of use, it can also be utilized as a protective layer to prevent unnecessary dissolution of the patch layer (X) due to excessive drying or exposure to the outside world.

[0042] When the saliva-soluble dental patch sheet of the present invention is applied to teeth, etc., the time from the start of application until the patch layer (X) is completely dissolved in saliva is preferably 3 to 30 minutes, more preferably 5 to 20 minutes, and even more preferably 8 to 12 minutes. Thus, the patch layer (X) in the saliva-soluble dental patch sheet of the present invention gradually dissolves in saliva over a long period of time, thereby continuously releasing and retaining component (a) or component (a') embedded in the sheet while maintaining good adhesion to teeth, etc., and therefore the action of component (a) or component (a') can be fully distributed and an excellent effect of preventing the adhesion of deposited stains can be exhibited.

[0043] The method of using the saliva-soluble dental patch sheet of the present invention is to apply it to both the front and back of teeth located on the upper and lower jaws and leave it for a while. The time to leave it for depends on the time required from the start of application to the teeth until the patch layer (X) completely dissolves, but it is preferably 3 to 30 minutes, more preferably 5 to 20 minutes, and even more preferably 8 to 12 minutes from immediately after application.

[0044] In particular, from the viewpoint of fully and effectively utilizing the excellent effect of preventing the adhesion of deposited stains by the saliva-soluble dental patch sheet of the present invention, it is preferable to apply it to both the front and back of the teeth, etc. after cleaning. In this way, by using the saliva-soluble dental patch sheet of the present invention, the effect of the present invention can be more effectively exerted on the teeth, etc. after the deposited stains have been effectively removed by cleaning, and it becomes possible to prevent the adhesion of deposited stains for a long period of time after the adhesive layer (X) is completely dissolved. EXAMPLES

[0045] The present invention will now be described in detail with reference to the following examples. In the tables, the content of each component is expressed as mass % unless otherwise specified.

[0046] [Examples 1 to 11, Comparative Examples 1 to 7] A stock solution (X) was prepared by mixing the respective components so as to obtain the patch layer (X) shown in Tables 1 and 2. Next, taking into consideration the thickness, the obtained raw solution (X) was applied onto a release layer (Z) film and dried to form an adhesive layer (X), and a saliva-soluble dental adhesive sheet was formed on the release layer (Z). The obtained sheet was used to carry out the measurements and evaluations according to the following methods. In the sheets of the examples shown in Tables 1 and 2, the strain at a tensile stress of 20 MPa was 2% or more. The results are shown in Tables 1 and 2.

[0047] <<Measurement of total moisture content of sheet>> The total moisture content of the obtained sheet was measured according to the method described above.

[0048] <Strain in sheet at tensile stress of 20 MPa> Using the obtained sheets, the strain of each sheet at a tensile stress of 20 MPa was measured according to the method described above.

[0049] <Time to leave the sheet on after application (minutes)> The surface of a 10 mm x 10 mm HAP pellet (APP-100, manufactured by HOYA Corporation) was lightly rubbed with water-soaked absorbent cotton to moisten it, and the obtained sheet was then attached to the surface of the HAP pellet and left for 10 minutes from the start of attachment.

[0050] The area of ​​the obtained saliva-soluble dental adhesive sheet and the mass (mg / cm) of component (a) per unit area of ​​the sheet 2 Measurement of The area of ​​the obtained sheet was measured and converted based on the content of component (a) in the saliva-soluble dental patch sheet.

[0051] <Evaluation of the effect of inhibiting the adhesion of dirt deposits> The surface of a 10 mm x 10 mm HAP pellet (APP-100, manufactured by HOYA Corporation) was roughened with water-resistant abrasive paper with a grit size of #400. Then, the attachment layer (X) of each sheet peeled off from the release layer (Z) was attached to the surface of a HAP plate that had been lightly rubbed with absorbent cotton soaked in water to moisten it, and after leaving it for 10 minutes, the sheets were removed from the surface of the HAP plate by brushing and washed with ion-exchanged water. Next, the washed HAP plate was immersed for 1 hour in a model solution of stain deposits prepared by mixing 0.01M CaCl2 (pH 8.0), 0.01M K2HPO4 (pH 8.0), and 1% bovine serum albumin (pH 5.2), and then stained with black tea (Nitto Black Tea, manufactured by Mitsui Norin Co., Ltd.) extract at 40°C for 15 hours. To quantify the degree of stain deposits, the stained HAP plate was photographed and the a of the HAP plate surface was analyzed by image analysis using Photoshop. * The value was calculated. The same treatment was also performed on the HAP board without the sheet attached, and the a * Values ​​were calculated as controls. HAP plate surface a * The decrease in value is the control a *The percentage value (%) was calculated with the value being 100%, and the value obtained was used as an index for evaluating the effect of inhibiting the adhesion of dirt deposits. Specifically, the effect of inhibiting the adhesion of dirt deposits was evaluated as follows: a rate of inhibition of the adhesion of dirt deposits of 50% or more was rated as "good", a rate of inhibition of the adhesion of dirt deposits of 10% or more but less than 50% was rated as "good", and a rate of inhibition of the adhesion of dirt deposits of less than 10% was rated as "bad".

[0052] <Evaluation of sheet handling> The adhesive layer (X) of the sheet peeled off from the release layer (Z) was applied to the upper and lower front teeth of a human, and the sheet was evaluated primarily for "ease of removal from the release layer (Z)," "ease of handling the film when applied," and "adhesion to the tooth surface after application," which were used as indicators for evaluating the "ease of handling the sheet." The specific evaluation of the handleability of the sheet was as follows: excellent handleability was rated as "◯", slightly poor handleability but within an acceptable range was rated as "Δ", and poor handleability was rated as "×".

[0053] [Table 1]

[0054] [Table 2]

[0055] [Example 12] An adhesive layer (X) was formed in the same manner as in Example 1 so as to obtain an adhesive layer (X) shown in Table 3. Next, a stock solution (Y) was prepared by mixing ethyl cellulose and propylene glycol using ethanol as a solvent so as to obtain an adhesive layer (Y) shown in Table 3, and the stock solution (Y) was then applied onto the adhesive layer (X) and dried to form a saliva-soluble dental patch sheet in which the adhesive layer (X) and the adhesive layer (Y) were laminated. The obtained sheet was used to carry out the measurements and evaluations in the same manner as in Example 1. In addition, in the sheet of Example 12, the strain at a tensile stress of 20 MPa was 2% or more. The results are shown in Table 3.

[0056]

Table 3

Claims

1. A saliva-soluble dental patch sheet comprising an adhesive layer (X) having a surface to be applied to teeth or the area surrounding the teeth, The patch layer (X) contains phytic acid or a salt thereof (a) and a water-soluble polymer (b), the mass ratio ((a) / moisture) of the content of component (a) to the total moisture content in the saliva-soluble dental patch sheet is 0.45 to 4; the mass ratio ((b) / (a)) of the content of component (b) to the content of component (a) in the saliva-soluble dental patch sheet is 2.5 to 12; The mass of component (a) per unit area of ​​the saliva-soluble dental adhesive sheet is 0.3 to 13 mg / cm 2 and A saliva-soluble dental patch sheet having a tensile stress of 20 MPa and a strain of 2% or more.

2. The surface area of ​​the adhesive layer (X) to be applied to the teeth or the area surrounding the teeth is 5 to 45 cm 2 2. The saliva-soluble dental patch according to claim 1,

3. 3. The saliva-soluble dental patch according to claim 1, wherein the total water content in the saliva-soluble dental patch is 3 to 20% by mass.

4. 4. The saliva-soluble dental patch sheet according to claim 1, wherein the solubility of component (b) in water at 20° C. is 10% by mass or more.

5. 5. The saliva-soluble dental patch sheet according to claim 1, wherein the time from the start of application to the teeth or the area surrounding the teeth until the patch layer (X) is completely dissolved is 3 to 30 minutes.

6. 6. A method for using the saliva-soluble dental patch sheet according to any one of claims 1 to 5, which comprises applying the sheet to the teeth or the area surrounding the teeth after cleaning and leaving the sheet for 3 to 30 minutes.

7. A saliva-soluble dental patch sheet comprising an adhesive layer (X) having a surface to be applied to teeth or the area surrounding the teeth, The patch layer (X) contains one or more acids or salts thereof (a') selected from malic acid, acetic acid, lactic acid, tartaric acid, citric acid, glycolic acid, succinic acid, and salts thereof, and a water-soluble polymer (b); the mass ratio ((a) / moisture) of the content of component (a') to the total moisture content in the saliva-soluble dental patch sheet is 0.45 to 4; the mass ratio ((b) / (a')) of the content of component (b) to the content of component (a') in the saliva-soluble dental patch sheet is 1.1 to 12; The mass of component (a') per unit area of ​​the saliva-soluble dental adhesive sheet is 0.3 to 13 mg / cm 2 and A saliva-soluble dental patch sheet having a tensile stress of 20 MPa and a strain of 2% or more.

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