Foaming skin care product

Abstract

To provide a carbon dioxide gas foamable external preparation for skin capable of efficiently exerting skin condition improvement effect by a specific active ingredient.SOLUTION: A carbon dioxide gas foamable external preparation for skin of the present invention is a carbon dioxide gas foamable external preparation for skin containing an acid substance, a carbon dioxide gas generating substance which reacts with the acid substance to generate carbon dioxide gas, and thickener, in the same agent or 2 or more agents, and furthermore contains ascorbic acid glucoside or the like (note that in the case where the carbon dioxide gas foamable external preparation for skin consists of 1 agent, it should be mixed with a water-containing substance when in use, and in the case where the carbon dioxide gas foamable external preparation for skin consists of 2 or more agents, any agent should contain water). It is preferable that the carbon dioxide gas foamable external preparation for skin furthermore contain polyhydric alcohol.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a foaming skin preparation for external use. [Background technology]

[0002] 2. Description of the Related Art External skin preparations containing synthetic or natural extracts that have a blood circulation promoting effect on the skin have been used in the past.

[0003] These extracts are insufficiently effective when used in small amounts, and are too irritating to the skin when used in large amounts, so topical skin preparations containing carbon dioxide gas to promote blood circulation have been proposed. Many of these generate carbon dioxide gas by reacting an acidic substance with a carbon dioxide gas-generating substance. Carbon dioxide gas-foaming topical skin preparations have traditionally contained plant extracts such as pine bark extracts that are considered to be effective (see Patent Document 1). On the other hand, it has long been known that carbon dioxide gas has the effect of promoting blood circulation, and for example, a warming pack cosmetic product containing a heat-generating substance is known (see Patent Document 2). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2014-88345 A [Patent Document 2] Japanese Patent Application Publication No. 08-268828 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the effects of plant extracts such as pine bark extract may be low, and there has been a demand for the development of a carbon dioxide gas-based foaming skin preparation that is more effective in improving skin conditions, such as by whitening the skin color, increasing the skin's moisture content, reducing water loss, and improving skin elasticity. Furthermore, although the foaming properties, foam duration, physical irritation, and the like of conventionally known pack agents containing carbon dioxide gas have been studied, there has not yet been sufficient study of the effect of carbon dioxide gas in improving skin conditions, nor has there been sufficient study of the usability and stability of the products, or the feel after rinsing.

[0006] In this invention, therefore, by blending a new ingredient into a carbon dioxide gas foaming skin preparation for external use, we have conducted various studies to find an active ingredient that not only improves skin condition, but also has excellent usability, safety, and stability, a good feel after rinsing, and can further enhance the effects of carbon dioxide gas. As a result, the inventors have found that the effects of carbon dioxide gas can be enhanced and the above-mentioned problems can be solved by incorporating a specific active ingredient into various carbon dioxide gas foaming skin preparations for external use, thus completing the present invention. [Means for solving the problem]

[0007] The present invention relates to a carbon dioxide gas foaming skin preparation for external use, which contains, in the same preparation or in two or more preparations, an acidic substance, a carbon dioxide gas generating substance which reacts with the acidic substance to generate carbon dioxide gas, and a thickener, and further contains ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizinic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, rezole, ethyl ester ... The present invention provides a carbon dioxide gas foaming skin preparation for external use which contains at least one selected from rusine, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate (however, when the carbon dioxide gas foaming skin preparation for external use consists of one agent, it is to be mixed with a water-containing substance at the time of use, and when it consists of two or more agents, one of the agents is to contain water) (hereinafter simply referred to as "external skin preparation").

[0008] The present invention also provides a carbon dioxide gas foaming skin preparation for external use (hereinafter simply referred to as a "skin preparation kit" or "kit") that is a two-agent kit of any of the following (1) to (3). In each of the following kits, the first agent and the second agent are mixed when used. (1) a first agent which is an acid-containing composition containing an acidic substance and water; and a second agent which is a base-containing composition containing a carbon dioxide gas generating substance which reacts with the acidic substance to generate carbon dioxide gas, wherein the first agent and / or the second agent contain a thickener, and further wherein the first agent and / or the second agent contain ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizinic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, It contains at least one selected from the group consisting of ferrol, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate. (2) a first agent which is an acid-containing composition containing an acidic substance; and a second agent which is a base-containing composition containing water and a carbon dioxide gas generating substance which reacts with the acidic substance to generate carbon dioxide gas, wherein the first agent and / or the second agent contain a thickening agent, and further wherein the first agent and / or the second agent contain ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizinic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, It contains at least one selected from the group consisting of copherol, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate. (3) a first agent which is an acid- and base-containing composition containing an acidic substance and a carbon dioxide gas generating substance which reacts with the acidic substance to generate carbon dioxide gas; and a second agent which is a composition containing water, wherein the first agent and / or the second agent contains a thickener, and further wherein the first agent and / or the second agent contains ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizinic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl arsenate, glycyrrhizinyl ester ... It contains at least one selected from chol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate.

[0009] The present invention also provides a carbon dioxide gas foamable skin preparation for topical use (hereinafter simply referred to as "composition for topical skin preparation" or "composition"), which is a one-part composition having the following composition to be mixed with a water-containing substance at the time of use. Composition: Contains an acidic substance, a carbonate, and a thickener, and further contains at least one selected from ascorbic acid glucoside, allantoin, estradiol, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhizinic acid, stearyl glycyrrhetinate, tranexamic acid, d-camphor, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, ethinyl estradiol, salicylic acid, biotin, resorcinol, trichlorocarbanilide, triclosan, benzethonium chloride, sulfur, photosensitizer No. 201, phenol, pyridoxine hydrochloride, pyridoxine, zinc oxide, arbutin, magnesium L-ascorbyl phosphate, ascorbyl dipalmitate, placenta, retinol, and retinol palmitate. Effect of the Invention

[0010] According to the present invention, by blending a specific active ingredient, the effect of carbon dioxide gas is enhanced, and thus, effects such as whitening the skin color, increasing the moisture content of the skin, reducing the amount of moisture evaporation, and improving skin elasticity are exhibited, thereby improving the skin condition, and at the same time, excellent usability such as ease of mixing and application, safety, and stability are achieved, and the feeling of use after rinsing is good, thereby further enhancing the effect of carbon dioxide gas, etc. Furthermore, it is possible to provide a carbon dioxide gas foaming skin preparation for external use that improves the condition of stratum corneum cells or / and promotes skin turnover, has excellent skin cell activation action, and has new effects such as reducing the size of skin pores and improving skin texture, as well as a kit and composition for obtaining said skin preparation for external use. [Brief description of the drawings]

[0011] [Figure 1A] FIG. 1A shows the results of skin condition measurements in Comparative Examples 1 to 3 and Examples 1-1 to 1-10, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 1B] FIG. 1B shows the results of skin condition measurements in Comparative Examples 1 to 3 and Examples 1-1 to 1-10, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 2A] FIG. 2A shows the results of skin condition measurements in Examples 1-11 to 1-20, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 2B] FIG. 2B shows the results of skin condition measurements in Examples 1-11 to 1-20, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 3A] FIG. 3A shows the results of skin condition measurements in Examples 1-21 to 1-30, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 3B] FIG. 3B shows the results of skin condition measurements in Examples 1-21 to 1-30, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 4A] FIG. 4A shows the results of skin condition measurements in Examples 1-31 to 1-35, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 4B]FIG. 4B shows the results of skin condition measurements in Examples 1-31 to 1-35, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 5A] FIG. 5A shows the results of skin condition measurements in Examples 2-1 to 2-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 5B] FIG. 5B shows the results of skin condition measurements in Examples 2-1 to 2-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 6A] FIG. 6A shows the results of skin condition measurements in Examples 3-1 to 3-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 6B] FIG. 6B shows the results of skin condition measurements in Examples 3-1 to 3-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 7A] FIG. 7A shows the results of skin condition measurements in Examples 4-1 to 4-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 7B] FIG. 7B shows the results of skin condition measurements in Examples 4-1 to 4-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 8A] FIG. 8A shows the results of skin condition measurements in Examples 5-1 to 5-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 8B] FIG. 8B shows the results of skin condition measurements in Examples 5-1 to 5-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 9A] FIG. 10A shows the results of skin condition measurements in Examples 6-1 to 6-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 9B] FIG. 10B shows the results of skin condition measurements in Examples 6-1 to 6-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 10A] FIG. 10A shows the results of skin condition measurements in Comparative Example 4 and Examples 7-1 to 7-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 10B]FIG. 10B shows the results of skin condition measurements in Comparative Example 4 and Examples 7-1 to 7-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 11A] FIG. 11A shows the results of skin condition measurements in Comparative Example 5 and Examples 8-1 to 8-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 11B] FIG. 11B shows the results of skin condition measurements in Comparative Example 5 and Examples 8-1 to 8-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 12A] FIG. 12A shows the results of skin condition measurements in Comparative Example 6 and Examples 9-1 to 9-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 12B] FIG. 12B shows the results of skin condition measurements in Comparative Example 6 and Examples 9-1 to 9-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 13A] FIG. 13A shows the results of skin condition measurements in Comparative Example 7 and Examples 10-1 to 10-5, where (a) shows the results of color difference and (b) shows the results of water evaporation. [Figure 13B] FIG. 13B shows the results of skin condition measurements in Comparative Example 7 and Examples 10-1 to 10-5, where (c) shows the results for stratum corneum moisture content and (d) shows the results for elasticity. [Figure 14] FIG. 14 shows the results of the turnover test for Comparative Examples 1 to 3 and Examples 1-1 to 1-10. [Figure 15] FIG. 15 shows the results of the turnover test for Examples 1-11 to 1-20. [Figure 16] FIG. 16 shows the results of the turnover test for Examples 1-21 to 1-30. [Figure 17] FIG. 17 shows the results of the turnover test for Examples 1-31 to 1-35. [Figure 18] FIG. 18 shows the results of the turnover test for Examples 2-1 to 2-5. [Figure 19] FIG. 19 shows the results of the turnover test for Examples 3-1 to 3-5. [Figure 20]FIG. 20 shows the results of the turnover test for Examples 4-1 to 4-5. [Figure 21] FIG. 21 shows the results of the turnover test for Examples 5-1 to 5-5. [Figure 22] FIG. 22 shows the results of the turnover test for Examples 6-1 to 6-5. [Figure 23] FIG. 23 shows the results of the turnover test for Comparative Example 4 and Examples 7-1 to 7-5. [Figure 24] FIG. 24 shows the results of the turnover test for Comparative Example 5 and Examples 8-1 to 8-5. [Diagram 25] FIG. 25 shows the results of the turnover test for Comparative Example 6 and Examples 9-1 to 9-5. [Figure 26] FIG. 26 shows the results of the turnover test for Comparative Example 7 and Examples 10-1 to 10-5. [Figure 27] FIG. 27 shows images of stratum corneum cells observed before and after the use of the foaming skin preparations for external use of Comparative Example 1, Examples 1-19, Examples 2-3, and Examples 4-3. [Figure 28] FIG. 28 shows the evaluation results of the cell activation activity of Comparative Examples 8 to 10 and Examples 11 to 13. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] The skin topical preparation, the kit for skin topical preparation, and the composition for skin topical preparation of the present invention will be described below based on their preferred embodiments. The kit for skin topical preparation and the composition for skin topical preparation of the present invention are each a form of the foaming skin topical preparation of the present invention. The foaming skin topical preparation of the present invention may contain an acidic substance, a carbon dioxide gas generating substance, a thickener, and the following specific components all in the same agent, or may contain them separately in multiple agents, and when divided into multiple agents, the four components may be divided in any way. However, the acidic substance, the carbon dioxide gas generating substance, and the amount of water required to generate carbon dioxide gas are not included in the same agent. The water content of the same agent containing the acidic substance and the carbon dioxide gas generating substance is preferably 15% by mass or less, more preferably 10% by mass or less, and particularly preferably 8% by mass or less.

[0013] The carbon dioxide gas foaming skin topical preparation of the present invention can be used in any form, such as a cosmetic, a quasi-drug, or a pharmaceutical. From the standpoint of effectiveness and usability, however, it is preferable to use it as a cosmetic or a quasi-drug (medicated cosmetic), and it is particularly preferable to use it as a quasi-drug (medicated cosmetic).

[0014] The carbon dioxide gas foamable skin preparation for external use according to the present invention can be applied externally to the skin including the scalp and hair, and can be used in various forms such as pack products, hair growth products, facial cleansers, cleansing products, skin lotions, milky lotions, beauty gels, shampoos, conditioners, etc. When washed off, it is preferably used in pack products, facial cleansers, and cleansing products.

[0015] First, the main components used in the skin external preparation, the kit for skin external preparation, and the composition for skin external preparation of the present invention will be described. Hereinafter, when the term "skin external preparation" is used, it may refer to the skin external preparation (e.g., the kit for skin external preparation, the composition for skin external preparation) before the carbon dioxide gas generating substance, the acidic substance, and water are contacted and these three are mixed, or it may refer to the carbon dioxide gas-containing skin external preparation after these are mixed (e.g., the one obtained by mixing the two agents of the kit, or the one obtained by mixing the composition for skin external preparation with a water-containing substance). Which one is referred to is determined according to the context. Below, the components contained in the skin external preparation, the kit, and the composition of the present invention are collectively described.

[0016] <Acidic substances> The acidic substance used in the present invention may be either an inorganic acid or an organic acid, and one or more of these may be used.

[0017] Examples of inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate, potassium acid pyrophosphate, and sulfamic acid.

[0018] Examples of the organic acid include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid, or salts thereof; dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid, or salts thereof; acidic amino acids such as glutamic acid and aspartic acid, or salts thereof; oxyacids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, and gluconic acid, or salts thereof; and examples of the inorganic acid include inorganic acids such as phosphoric acid and sulfurous acid, or salts thereof. One or more of these can be used.

[0019] Among these, citric acid, ascorbic acid, malic acid and succinic acid are preferred from the viewpoints of safety and solubility in water.

[0020] The content of the acidic substance in the skin external preparation of the present invention is preferably 0.01 to 30 parts by mass, more preferably 0.05 to 20 parts by mass, based on 100 parts by mass of the skin external preparation, from the viewpoint of efficiently expressing the cosmetic effect. Similarly, the content of the acidic substance in the acid-containing composition of the kits (1) and (2) and the content of the acidic substance in the acid- and base-containing composition of the kit (3) are preferably 0.01 to 30 parts by mass, more preferably 0.05 to 20 parts by mass, based on 100 parts by mass of the total amount of the two agents in the corresponding kit. In the present specification, the amount of the skin external preparation may be the total amount of each agent in the kit at the start of mixing the components of each kit when the skin external preparation of the present invention is a kit of two or more agents, and when the skin external preparation is obtained by mixing a one-agent skin external preparation composition and a water-containing substance, it may be the total amount of the composition and the water-containing substance at the start of mixing.

[0021] Furthermore, the content of the acidic substance in the acid-containing composition (acid-containing aqueous composition) in the kit (1) of the present invention is preferably 0.01% by mass or more and 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less, in the acid-containing composition (acid-containing aqueous composition). The content of the acidic substance in the acid-containing composition in the kit (2) of the present invention is preferably 0.1% by mass or more and 90% by mass or less, and more preferably 0.5% by mass or more and 80% by mass or less, of the solid content of the acid-containing composition. The content of the acidic substance in the acid- and base-containing composition in the kit (3) of the present invention is preferably 0.01% by mass or more and 50% by mass or less, and more preferably 0.05% by mass or more and 40% by mass or less, of the solid content of the acid- and base-containing composition. The content of the acidic substance in the composition for topical skin preparation of the present invention is preferably 0.01% by mass or more and 40% by mass or less, and more preferably 0.05% by mass or more and 30% by mass or less, of the solid content of the composition for topical skin preparation.

[0022] <Carbon dioxide generating substances> The carbon dioxide gas generating substance used in the present invention which reacts with the acidic substance to generate carbon dioxide gas may be any substance which reacts with the acidic substance to generate carbon dioxide gas.

[0023] Examples of the carbon dioxide gas generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate, and hydrogen carbonates such as ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate, and calcium hydrogen carbonate, and one or more of these are used. Among these, hydrogen carbonates are preferably used, and sodium hydrogen carbonate is more preferred in that it can realize a suitable foaming power.

[0024] The content of the carbon dioxide gas generating substance in the skin external preparation of the present invention is preferably 0.01 to 30% by mass, more preferably 0.05 to 20% by mass, based on 100 parts by mass of the skin external preparation. Similarly, the content of the carbon dioxide gas generating substance in the base-containing composition of the kits (1) and (2) and the content of the carbon dioxide gas generating substance in the acid- and base-containing composition of the kit (3) are preferably 0.01 to 30 parts by mass, more preferably 0.05 to 20 parts by mass, based on 100 parts by mass of the total amount of the two agents in the corresponding kit.

[0025] The content of the carbon dioxide gas generating substance in the base-containing composition in the kit (1) of the present invention is preferably 0.1% by mass or more and 90% by mass or less, and more preferably 0.5% by mass or more and 80% by mass or less, of the solid content of the base-containing composition. The content of the carbon dioxide gas generating substance in the base-containing composition (water-containing composition) in the kit (2) of the present invention is preferably 0.01% by mass or more and 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less, in the base-containing composition. The content of the carbon dioxide gas generating substance in the acid- and base-containing composition in the kit (3) of the present invention is preferably from 0.01% by mass to 50% by mass, and more preferably from 0.05% by mass to 40% by mass, of the solid content of the acid- and base-containing composition. The content of the carbon dioxide gas generating substance in the composition for topical skin preparation of the present invention is preferably 0.01 mass% or more and 40 mass% or less, and more preferably 0.05 mass% or more and 30 mass% or less, of the solid content of the composition for topical skin preparation.

[0026] <Thickener> Examples of thickeners used in the present invention include various types of thickeners that can be used in the fields of cosmetics and pharmaceuticals. Examples of thickeners that can be used include synthetic polymers, semi-synthetic polymers, natural polymers, clay minerals, etc. Specifically, synthetic polymers include hydrophilic synthetic polymers such as carboxyvinyl polymers, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymers, acrylates / alkyl acrylate crosspolymers, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymers, carboxymethylcellulose, cationized cellulose, and (PEG-240 / decyltetradeceth-20 / HDI) copolymers, and semi-synthetic polymers include cellulose derivatives such as carboxymethylcellulose or its salts, methylcellulose, ethylcellulose, propylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and sulfonated cellulose derivatives. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid esters, gelatin fatty acid esters, and gelatin fatty acid amides. Examples of natural polymers include polysaccharides and derivatives thereof, such as xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, alginic acid or its salts, gum arabic, pectin, quince seed, starch, algae colloid, chondroitin sulfate or its salts, chitosan and its derivatives, nucleic acid or its salts, ribonucleic acid or its salts, water-soluble proteins such as casein, collagen, gelatin, albumin, fibroin, elastin, keratin, and sericin, mucopolysaccharides such as hyaluronic acid or its salts, and chondroitin sulfate, etc. Examples of clay minerals include laponite, bentonite, smectite kaolinite, and montmorillonite. Preferred examples of the above salts include alkali metal salts, such as sodium salts and potassium salts.

[0027] In the present invention, one or more of the above thickeners can be used, but among the above thickeners, it is preferable to use one that is highly soluble or dispersible in water, since it can reduce the rough feeling on the skin caused by undissolved or undispersed components during use. Here, the solubility in water can be judged by whether or not the thickener has sufficient viscosity by instantly dissolving or dispersing in water when water at room temperature is added and stirred, and by whether or not lumps are formed during dissolution or dispersion.

[0028] Among the thickeners, preferred ones from the viewpoint of the above-mentioned solubility and dispersibility in water include, for example, carboxyvinyl polymer, carboxymethylcellulose or salts thereof, polyvinyl alcohol, PEG-240 / decyltetradeceth-20 / HDI copolymer, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, cellulose derivatives (celluloses), galactan, gum arabic, tragacanth gum, tamarind gum, agar, mannan, curdlan, alginic acid or salts thereof, collagen, gelatin, albumin, and the like. Particularly preferred ones include alginic acid or salts thereof, hydroxyethyl ether, carboxymethylcellulose or salts thereof, xanthan gum, carrageenan, tamarind gum, and albumin.

[0029] The amount of the thickener contained in the skin external preparation of the present invention is preferably 0.01 to 40 parts by mass, more preferably 0.1 to 30 parts by mass, based on 100 parts by mass of the skin external preparation. Similarly, the content of the thickener in the acid-containing composition and / or base-containing composition in the kits (1) and (2) and the content of the thickener in the acid- and base-containing composition and / or water-containing composition in the kit (3) are preferably 0.01 to 40 parts by mass, more preferably 0.1 to 30 parts by mass, based on 100 parts by mass of the total amount of the two agents in the corresponding kit. The amount of the thickener in the acid-containing composition and / or base-containing composition referred to here refers to the amount of the thickener when one of them contains a thickener, and refers to the total amount when both contain a thickener, and the same applies to the amount of the thickener in the base-containing composition and / or water-containing composition.

[0030] Furthermore, the content of the thickener in the composition for topical skin preparation of the present invention is preferably 0.1% by mass or more and 40% by mass or less, and more preferably 0.5% by mass or more and 30% by mass or less, of the solid content of the composition for topical skin preparation.

[0031] <Water> The water that can be used in the present invention may be water that can be used in cosmetics, external medicines, quasi-drugs, etc., but purified water, distilled water, membrane-filtered water, and ion-exchanged water are preferred.

[0032] The amount of water in the skin external preparation of the present invention (or the amount of water used in the skin external preparation) is preferably 20 parts by mass or more and 95 parts by mass or less, and more preferably 30 parts by mass or more and 90 parts by mass or less, relative to 100 parts by mass of the skin external preparation, from the viewpoint of fully exerting the cosmetic effect according to the present invention. In the case of a composition for a skin external preparation, the amount of water referred to here is the ratio of water to the total amount of water and the amount of composition. Similarly, the content of water in the kits (1) to (3) is preferably 20 parts by mass or more and 95 parts by mass or less, and more preferably 30 parts by mass or more and 90 parts by mass or less, relative to 100 parts by mass of the total amount of the two agents in the corresponding kit. The amount of water in the kit referred to here is the total amount of water in the two agents, and is the amount of water in the agent when only one of the two agents contains water.

[0033] <Polyhydric alcohol> In the present invention, it is preferable that the skin external preparation contains a polyhydric alcohol, because it can exert a high moisturizing effect by combining with a specific component described later. Examples of polyhydric alcohols include polyglycerols such as glycerin, diglycerin, triglycerin, and tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, 1,2-pentanediol, sorbitol, polyglycerol derivatives, reducing sugars such as glucose, fructose, glyceraldehyde, lactose, arabinose, and maltose, and sugar alcohols such as erythritol, maltitol, sorbitol, and xylitol, and one or more of these can be used in combination. Among them, the number of carbon atoms is preferably 2 or more, and the valence is preferably 2 or more, because of the high moisturizing effect.

[0034] The amount of polyhydric alcohol contained in the skin external preparation of the present invention is preferably 1 part by mass or more and 80 parts by mass or less, more preferably 5 parts by mass or more and 70 parts by mass or less, based on 100 parts by mass of the skin external preparation, from the viewpoint of fully exerting the beauty effect by combining with the above-mentioned specific component. Similarly, the content of polyhydric alcohol in the acid-containing composition and / or base-containing composition in the kits (1) and (2) and the content of polyhydric alcohol in the acid- and base-containing composition and / or water-containing composition in the kit (3) are preferably 1 part by mass or more and 80 parts by mass or less, more preferably 5 parts by mass or more and 70 parts by mass or less, based on 100 parts by mass of the total amount of the two agents in the corresponding kit. The amount of polyhydric alcohol in the acid-containing composition and / or base-containing composition referred to here is the amount of polyhydric alcohol when one of them contains polyhydric alcohol, and the total amount when both contain polyhydric alcohol, and the amount of polyhydric alcohol in the base-containing composition and / or water-containing composition is the same.

[0035] One of the features of the skin external preparation of the present invention is that it contains a specific active ingredient (hereinafter also referred to as a specific ingredient). Such an ingredient will be described in detail below.

[0036] <Ascorbic acid glucoside> Ascorbic acid glucoside includes 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G, ascorbic acid-2-glucoside, L-ascorbic acid 2-glucoside, etc.). Ascorbic acid glucoside may be isolated from nature or biochemically synthesized. Ascorbic acid glucoside is said to have a melanin production inhibitory effect and is used in cosmetics and quasi-drugs for whitening. The present inventors have found that the effect of this ascorbic acid glucoside is efficiently exerted in a carbon dioxide gas-forming external skin preparation obtained when it is mixed with an acidic substance, a carbon dioxide gas-generating substance, a thickener, and water. Ascorbic acid glucoside may be contained in any of the kits (1) to (3), or may be contained in a one-agent type composition for an external skin preparation. When ascorbic acid glucoside is included in a two-drug kit, it may be used in any of the following forms: one of the two drugs is in gel form and the other is in solid form, one of the two drugs is in gel form and the other is in liquid form, both drugs are in gel form, one of the two drugs is in liquid form and the other is in solid form, or both drugs are in liquid form. Drugs containing the following various specific ingredients, including ascorbic acid glucoside, may be in solid, liquid, or gel form.

[0037] In the present invention, the amount of ascorbic acid glucoside in the skin topical preparation is preferably 0.01% by mass or more and 20% by mass or less, from the viewpoint of efficiently exerting the advantageous effects of ascorbic acid glucoside. From this viewpoint, the amount of ascorbic acid glucoside in the skin topical preparation is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, and particularly preferably 0.1 parts by mass or more and 5 parts by mass or less. Similarly, the content of ascorbic acid glucoside in the acid-containing composition and / or base-containing composition in the kits (1) and (2) and the content of ascorbic acid glucoside in the acid- and base-containing composition and / or water-containing composition in the kit (3) are preferably 0.01 parts by mass or more and 20 parts by mass or less, more preferably 0.05 parts by mass or more and 10 parts by mass or less, and particularly preferably 0.1 parts by mass or more and 5 parts by mass or less, relative to the total amount of the two agents in the corresponding kit (100 parts by mass). The amount of ascorbic acid glucoside in the acid-containing composition and / or the base-containing composition referred to here means the amount of ascorbic acid glucoside when either one of them contains ascorbic acid glucoside, and means the total amount when both contain ascorbic acid glucoside. The same applies to the amount of ascorbic acid glucoside in the acid- and base-containing composition and / or the water-containing composition.

[0038] When ascorbic acid glucoside is contained in the kit (1), it may be contained in either the acid-containing composition (water-containing composition) or the base-containing composition. When ascorbic acid glucoside is contained in the acid-containing composition of the kit (1), from the viewpoint of efficiently exerting the advantageous effects of ascorbic acid glucoside, its content in the acid-containing composition is preferably 0.01% by mass or more and 20% by mass or less, and more preferably 0.05% by mass or more and 10% by mass or less. When ascorbic acid glucoside is contained in the base-containing composition of the kit (1), its content in the solid content of the base-containing composition is preferably 0.1% by mass or more and 90% by mass or less, and more preferably 0.5% by mass or more and 80% by mass or less.

[0039] When ascorbic acid glucoside is contained in the kit (2), it is preferable that it is contained in the acid-containing composition, because the effect of ascorbic acid glucoside can be efficiently exerted in the skin topical preparation. On the other hand, when it is contained in the base-containing composition, it is difficult for it to exist stably in the kit. When ascorbic acid glucoside is contained in the acid-containing composition of the kit (2), its content is preferably 90 mass% or less, more preferably 0.1 mass% or more and 80 mass% or less, based on the solid content of the acid-containing composition.

[0040] When ascorbic acid glucoside is contained in the kit (3), it may be contained in either the acid- and carbonate-containing composition or the water-containing composition. When ascorbic acid glucoside is contained in the acid- and carbonate-containing composition of the kit (3), its content is preferably 0.1% by mass to 50% by mass, more preferably 0.5% by mass to 40% by mass, based on the solid content of the acid- and carbonate-containing composition. When ascorbic acid glucoside is contained in the water-containing composition of the kit (3), its content is preferably 0.01% by mass to 20% by mass, more preferably 0.05% by mass to 10% by mass, based on the solid content of the acid- and carbonate-containing composition.

[0041] The content of ascorbic acid glucoside in the composition for topical skin preparations of the present invention is preferably from 0.1% by mass to 30% by mass, and more preferably from 0.5% by mass to 20% by mass, of the solid content of the composition for topical skin preparations.

[0042] <Another specific ingredient> The skin topical preparation, the kit for skin topical preparation, and the composition for skin topical preparation of the present invention can exhibit beauty effects and the like due to the inclusion of specific active ingredients other than ascorbic acid glucoside. Such ingredients are listed below. The preferred ratio of the specific ingredient contained in the kit for skin topical preparation of the present invention to the total amount of the two agents is the same as the preferred amount of the specific ingredient in the skin topical preparation shown below. The preferred content of the specific ingredient in the composition for skin topical preparation is the same as the preferred amount of the specific ingredient in the solid content of the skin topical preparation shown below.

[0043] Allantoin is C 4 H 6 N 4 O 3 It is a compound having the composition, which is a diureide of glyoxylic acid. It is also known as 5-ureidohydantoin or glyoxydiureide, and is known as an anti-inflammatory agent. When the skin topical preparation contains allantoin, the amount of allantoin in the skin topical preparation is preferably 0.001% by mass or more and 20% by mass or less, more preferably 0.01% by mass or more and 10% by mass or less. The amount of allantoin is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less, based on the solid content of the skin topical preparation.

[0044] When allantoin is contained in the acid-containing composition of the kit (1), its content is preferably 0.01% by mass or more and 20% by mass or less in the acid-containing composition, more preferably 0.05% by mass or more and 10% by mass or less.When allantoin is contained in the base-containing composition of the kit (1), its content is preferably 0.01% by mass or more and 30% by mass or less in the solid content of the base-containing composition, more preferably 0.05% by mass or more and 20% by mass or less.

[0045] When allantoin is contained in the acid-containing composition of the kit (2), its content is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less, based on the solid content of the acid-containing composition. When allantoin is contained in the base-containing composition of the kit (2), its content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, based on the solid content of the acid-containing composition.

[0046] When allantoin is contained in the acid- and carbonate-containing composition of the kit (3), its content is preferably 0.01% by mass or more and 30% by mass or less, more preferably 0.05% by mass or more and 20% by mass or less, based on the solid content of the acid- and carbonate-containing composition. When allantoin is contained in the water-containing composition of the kit (3), its content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, based on the solid content of the acid- and carbonate-containing composition.

[0047] Tranexamic acid is also called trans-4-(aminomethyl)cyclohexane carboxylic acid, and is known as an anti-inflammatory agent and a skin whitening agent. When the skin topical preparation contains tranexamic acid, the amount of tranexamic acid in the skin topical preparation is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.1% by mass or more and 10% by mass or less. The amount of tranexamic acid in the solid content of the skin topical preparation is preferably 0.1% by mass or more and 80% by mass or less, more preferably 1% by mass or more and 70% by mass or less.

[0048] When tranexamic acid is contained in the acid-containing composition of the kit (1), its content in the acid-containing composition is preferably 0.1% by mass to 60% by mass, more preferably 1% by mass to 50% by mass. When tranexamic acid is contained in the base-containing composition of the kit (1), its content in the solid content of the base-containing composition is preferably 1% by mass to 90% by mass, more preferably 5% by mass to 80% by mass.

[0049] When tranexamic acid is contained in the acid-containing composition of the kit (2), its content is preferably 1% by mass to 90% by mass, more preferably 5% by mass to 80% by mass, based on the solid content of the acid-containing composition.When tranexamic acid is contained in the base-containing composition of the kit (2), its content is preferably 0.1% by mass to 60% by mass, more preferably 1% by mass to 50% by mass, based on the solid content of the base-containing composition.

[0050] When tranexamic acid is contained in the acid- and carbonate-containing composition of the kit (3), its content is preferably 0.1% by mass to 80% by mass, more preferably 1% by mass to 75% by mass, based on the solid content of the acid- and carbonate-containing composition. When tranexamic acid is contained in the water-containing composition of the kit (3), its content is preferably 0.01% by mass to 30% by mass, more preferably 0.1% by mass to 20% by mass, based on the solid content of the acid- and carbonate-containing composition.

[0051] The chemical name of d-camphor is (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one. It is one of the bicyclic monoterpene ketones, and is found in camphor trees and obtained by steam distillation of wood pieces. When the skin topical preparation contains d-camphor, the amount of d-camphor in the skin topical preparation is preferably 0.001% by mass or more and 10% by mass or less. The amount of d-camphor in the solid content of the skin topical preparation is preferably 0.01% by mass or more and 10% by mass or less.

[0052] Salicylic acid has the chemical formula C 7 H 6 O 3 When the topical skin preparation contains salicylic acid, the amount of salicylic acid in the topical skin preparation is preferably 0.0001% by mass or more and 10% by mass or less. The amount of salicylic acid in the solid content of the topical skin preparation is preferably 0.001% by mass or more and 10% by mass or less.

[0053] Biotin is called D-[(+)-cis-hexahydro-2-oxo-1H-thieno-(3,4)-imidazole-4-valeric acid] and is a water-soluble vitamin classified as a vitamin B group. When the skin topical preparation contains biotin, the amount of biotin in the skin topical preparation is preferably 0.0001% by mass or more and 1% by mass or less. The amount of biotin in the solid content of the skin topical preparation is preferably 0.0001% by mass or more and 10% by mass or less.

[0054] Resorcinol has the chemical formula C 6 H 4 (OH) 2 It is a compound represented by the formula: and corresponds to 1,3-dihydroxybenzene. When the skin topical preparation contains resorcin, the amount of resorcin in the skin topical preparation is preferably 0.001% by mass or more and 10% by mass or less. The amount of resorcin is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the skin topical preparation.

[0055] Trichlorocarbanilide is also called triclocarban or 3,4,4'-trichlorocarbanilide. When the topical skin preparation contains trichlorocarbanilide, the amount of trichlorocarbanilide in the topical skin preparation is preferably 0.001% by mass or more and 10% by mass or less. In addition, the amount of trichlorocarbanilide in the solid content of the topical skin preparation is preferably 0.01% by mass or more and 20% by mass or less.

[0056] Triclosan is also known as 5-chloro-2-(2',4'-dichlorophenoxy)phenol. When the topical skin preparation contains triclosan, the amount of triclosan in the topical skin preparation is preferably 0.0001% by mass or more and 10% by mass or less. The amount of triclosan in the solid content of the topical skin preparation is preferably 0.001% by mass or more and 10% by mass or less.

[0057] Benzethonium chloride has the chemical formula C 27 H 42 ClNO 2 It is a type of cationic surfactant. When the skin topical preparation contains benzethonium chloride, the amount of benzethonium chloride in the skin topical preparation is preferably 0.0001% by mass or more and 10% by mass or less. The amount of benzethonium chloride in the solid content of the skin topical preparation is preferably 0.001% by mass or more and 10% by mass or less.

[0058] Sulfur is a simple substance represented by the chemical formula S. When the topical skin preparation contains sulfur, the amount of sulfur in the topical skin preparation is preferably 0.001% by mass or more and 20% by mass or less. The amount of sulfur is preferably 0.01% by mass or more and 20% by mass or less in the solid content of the topical skin preparation.

[0059] Photosensitizer No. 201 is also called pionin. When the topical skin preparation contains Photosensitizer No. 201, the amount of the photosensitizer in the topical skin preparation is preferably 0.0001% by mass or more and 5% by mass or less. The amount of pionin is preferably 0.0005% by mass or more and 10% by mass or less of the solid content of the topical skin preparation.

[0060] Pyridoxine is a water-soluble compound called 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol or vitamin B6. When the skin topical preparation contains pyridoxine, the amount of pyridoxine in the skin topical preparation is preferably 0.0001% by mass or more and 5% by mass or less. The amount of pyridoxine in the solid content of the skin topical preparation is preferably 0.0005% by mass or more and 10% by mass or less.

[0061] Pyridoxine hydrochloride is pyridoxine converted to hydrochloride and is also called 5-hydroxy-6-methylpyridine-3,4-dimethanol monohydrochloride. When the topical skin preparation contains pyridoxine hydrochloride, the amount of pyridoxine hydrochloride in the topical skin preparation is preferably 0.001% by mass or more and 10% by mass or less. The amount of pyridoxine hydrochloride in the solid content of the topical skin preparation is preferably 0.01% by mass or more and 10% by mass or less.

[0062] Zinc oxide is represented by the chemical formula ZnO. When the topical skin preparation contains zinc oxide, the amount of zinc oxide in the topical skin preparation is preferably 0.01% by mass or more and 20% by mass or less. Also, the amount of zinc oxide in the solid content of the topical skin preparation is preferably 0.05% by mass or more and 20% by mass or less.

[0063] Arbutin includes β-arbutin and α-arbutin, and β-arbutin called 4-(β-D-glucopyranosyloxy)phenol is common.When skin external preparation contains arbutin, its amount is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.1% by mass or more and 10% by mass or less in the skin external preparation.Also, the amount of arbutin is preferably 0.1% by mass or more and 50% by mass or less, more preferably 1% by mass or more and 40% by mass or less in the solid content of the skin external preparation.

[0064] When arbutin is contained in the acid-containing composition of the kit (1), its content in the acid-containing composition is preferably 0.1% by mass to 30% by mass, more preferably 1% by mass to 20% by mass. When arbutin is contained in the base-containing composition of the kit (1), its content in the solid content of the base-containing composition is preferably 1% by mass to 90% by mass, more preferably 5% by mass to 85% by mass.

[0065] When arbutin is contained in the acid-containing composition of the kit (2), its content is preferably 1% by mass to 90% by mass, more preferably 5% by mass to 85% by mass, based on the solid content of the acid-containing composition. When arbutin is contained in the base-containing composition of the kit (2), its content is preferably 0.1% by mass to 30% by mass, more preferably 1% by mass to 20% by mass, based on the solid content of the acid-containing composition.

[0066] When arbutin is contained in the acid- and carbonate-containing composition of the kit (3), its content is preferably 1% by mass to 80% by mass, more preferably 5% by mass to 70% by mass, based on the solid content of the acid- and carbonate-containing composition. When arbutin is contained in the water-containing composition of the kit (3), its content is preferably 0.1% by mass to 30% by mass, more preferably 1% by mass to 20% by mass, based on the solid content of the acid- and carbonate-containing composition.

[0067] Magnesium L-ascorbyl phosphate is also known as magnesium L-ascorbyl phosphate. When the skin topical preparation contains magnesium L-ascorbyl phosphate, the amount of magnesium L-ascorbyl phosphate in the skin topical preparation is preferably 0.01% by mass or more and 20% by mass or less. In addition, the amount of magnesium L-ascorbyl phosphate in the skin topical preparation is preferably 0.05% by mass or more and 20% by mass or less in the solid content of the skin topical preparation.

[0068] Ascorbyl dipalmitate is also called L-ascorbic acid 2,6-dipalmitate. When the skin topical preparation contains ascorbyl palmitate, the amount of ascorbyl palmitate in the skin topical preparation is preferably 0.01% by mass or more and 20% by mass or less. In addition, the amount of ascorbyl palmitate in the solid content of the skin topical preparation is preferably 0.05% by mass or more and 20% by mass or less.

[0069] Examples of glycyrrhizinic acid include β-glycyrrhizinic acid. Examples of glycyrrhizinic acid derivatives include dipotassium glycyrrhizinate (sometimes called dipotassium glycyrrhizinate), monoammonium glycyrrhizinate, and stearyl glycyrrhizinate. Monoammonium glycyrrhizinate may be anhydrous or hydrated. When the skin topical preparation contains these glycyrrhizinic acid and its derivatives, the amount of each of them and the total amount in the skin topical preparation is preferably 0.0001% by mass or more and 10% by mass or less, more preferably 0.001% by mass or more and 1% by mass or less. The content of glycyrrhizinic acid and its derivatives is preferably 0.001% by mass or more and 20% by mass or less, more preferably 0.005% by mass or more and 10% by mass or less, in the solid content of the skin topical preparation.

[0070] When glycyrrhizic acid and its derivatives are contained in the acid-containing composition of the kit (1), the content is preferably 0.001% by mass to 10% by mass in the acid-containing composition, more preferably 0.005% by mass to 5% by mass in the acid-containing composition. When glycyrrhizic acid and its derivatives are contained in the base-containing composition of the kit (1), the content is preferably 0.01% by mass to 20% by mass in the solid content of the base-containing composition, more preferably 0.05% by mass to 10% by mass in the base-containing composition.

[0071] When glycyrrhizic acid and its derivatives are contained in the acid-containing composition of the kit (2), the content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, based on the solid content of the acid-containing composition. When glycyrrhizic acid and its derivatives are contained in the base-containing composition of the kit (2), the content is preferably 0.001% by mass or more and 10% by mass or less, more preferably 0.005% by mass or more and 5% by mass or less, based on the solid content of the acid-containing composition.

[0072] When glycyrrhizic acid and its derivatives are contained in the acid- and carbonate-containing composition of the kit (3), the content is preferably 0.01% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 10% by mass or less, based on the solid content of the acid- and carbonate-containing composition. When glycyrrhizic acid and its derivatives are contained in the water-containing composition of the kit (3), the content is preferably 0.001% by mass or more and 10% by mass or less, more preferably 0.050% by mass or more and 5% by mass or less, based on the solid content of the acid- and carbonate-containing composition.

[0073] Each of the above-mentioned preferred amounts of glycyrrhizinic acid and its derivatives may be the amount of one of glycyrrhizinic acid and its derivatives, or the total amount of glycyrrhizinic acid and its derivatives.

[0074] Retinol is also known as vitamin A. When the topical skin preparation contains retinol, the amount of retinol in the topical skin preparation is preferably 0.00001% by mass or more and 20% by mass or less, and more preferably 0.00005% by mass or more and 10% by mass or less, based on the solid content of the topical skin preparation.

[0075] Retinol palmitate is also called vitamin A palmitate. When the skin topical preparation contains retinol palmitate, the amount of retinol palmitate in the skin topical preparation is preferably 0.00001% by mass or more and 20% by mass or less. In addition, the amount of retinol palmitate in the skin topical preparation is preferably 0.00005% by mass or more and 10% by mass or less in the solid content of the skin topical preparation.

[0076] The generic name of estradiol is estra-1.3.5(10)triene-3.17β-diol. The generic name of ethinylestradiol is 17-ethynylestradiol-1,3,5(10)-triene-3β,17β-diol. When the skin topical preparation contains these estradiols, the amount of each estradiol and the total amount of each estradiol in the skin topical preparation is preferably 0.00001% by mass or more and 5% by mass or less. In addition, the amount of each estradiol in the skin topical preparation is preferably 0.00005% by mass or more and 10% by mass or less in the solid content of the skin topical preparation.

[0077] Both dl-α tocopherol acetate and dl-α tocopherol nicotinate are known as vitamin E derivatives. When the skin topical preparation contains dl-α tocopherol acetate and / or dl-α tocopherol nicotinate, the amount of each of them and the total amount of each of them in the skin topical preparation is preferably 0.0001% by mass or more and 10% by mass or less. In addition, it is preferably 0.001% by mass or more and 10% by mass or less in the solid content of the skin topical preparation.

[0078] D-pantothenyl alcohol is also called (R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide. When the skin topical preparation contains D-pantothenyl alcohol, the amount of D-pantothenyl alcohol in the skin topical preparation is preferably 0.01% by mass or more and 20% by mass or less. In addition, the amount of D-pantothenyl alcohol in the solid content of the skin topical preparation is preferably 0.05% by mass or more and 20% by mass or less.

[0079] Pantothenyl ethyl ether is also called (2R)-N-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide. When the skin external preparation contains pantothenyl ethyl ether, the amount of pantothenyl ethyl ether is preferably 0.001% by mass or more and 10% by mass or less in the skin external preparation. In addition, the amount of pantothenyl ethyl ether is preferably 0.005% by mass or more and 10% by mass or less in the solid content of the skin external preparation.

[0080] Phenol has the rational formula C 6 H 5OH, and has a structure in which one of the hydrogen atoms of benzene is replaced by a hydroxyl group. When the skin topical preparation contains phenol, the amount of phenol in the skin topical preparation is preferably 0.001% by mass or more and 10% by mass or less. In addition, the amount of phenol in the solid content of the skin topical preparation is preferably 0.005% by mass or more and 10% by mass or less.

[0081] Placenta refers to the general term for growth factors and other nutrients that promote cell division in animal, preferably pig, horse, cow, sheep, and human placenta, nutrients in the ovarian membrane of fish, and nutritional components in plant germ. The placenta used in the present invention is not particularly limited as long as it can be used as a normal cosmetic or quasi-drug. In the present invention, commercially available water-soluble extracts and powders can be used. When the skin topical preparation contains placenta, the amount of placenta is preferably 0.01% by mass or more and 20% by mass or less in the skin topical preparation. In addition, it is preferably 0.05% by mass or more and 20% by mass or less in the solid content of the skin topical preparation.

[0082] Of these specific components, allantoin, dipotassium glycyrrhizinate, stearyl glycyrrhizinate, d-camphor, salicylic acid, arbutin and placenta are preferably contained in a two-drug skin topical preparation kit, particularly in the kit (1) or (2) in the present invention. Needless to say, the specific components, including these, may be contained in a one-drug skin topical preparation composition or in a two-drug skin topical preparation kit. In particular, it is preferable that the specific components are used in a two-drug kit in terms of increasing the keratin moisture content after use and exhibiting an excellent turnover effect. In addition, the effect of improving skin condition and the effect of improving the feeling of use of the present invention are not limited by the type of thickener, but the desired effect among these can be further enhanced by the type of thickener combined with the specific components.

[0083] Each specific component may be used in any of the following: one of the two agents is gel-like and the other is solid; one of the two agents is gel-like and the other is liquid; both agents are gel-like; one of the two agents is liquid and the other is solid; or both agents are liquid. For dl-α tocopherol acetate, it is preferred to use in any of the following: one of the two agents is gel-like and the other is liquid; both agents are gel-like; one of the two agents is liquid and the other is solid; or both agents are liquid. Furthermore, for placenta, it is preferred to use in any of the following: one of the two agents is gel-like and the other is solid; one of the two agents is gel-like and the other is liquid; both agents are gel-like; or both agents are liquid.

[0084] In the kits (1) to (3), it is preferable that estradiol, ethinylestradiol, dl-α-tocopherol nicotinate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, phenol, and placenta are contained in the aqueous composition (the acid-containing composition of the kit (1), the base-containing composition of the kit (2), and the aqueous composition of the kit (3)) in order to exert their effects. The amount of these specific components (estradiol, ethinylestradiol, dl-α-tocopherol nicotinate, dl-α-tocopherol nicotinate, D-pantothenyl alcohol, pantothenyl ethyl ether, phenol, and placenta) contained in these aqueous compositions in the kits (1) to (3) is preferably the same as the preferred ratio of these specific components in the skin topical preparation described above in the total amount of the two agents.

[0085] Regarding allantoin, glycyrrhizinic acid and its derivatives, tranexamic acid, d-camphor, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzonium chloride, sulfur, photosensitizer No. 201, pyridoxines, zinc oxide, arbutin, retinol, and retinol palmitate, they are preferably contained in the base-containing composition or acid-containing composition of kit (1), the acid-containing composition of kit (2), or the acid- and base-containing composition of kit (3) in order to exert their effects. The amount of these specific ingredients (allantoin, glycyrrhizinic acid and its derivatives, tranexamic acid, d-camphor, salicylic acid, biotin, resorcin, trichlorocarbanilide, triclosan, benzonium chloride, sulfur, photosensitizer No. 201, pyridoxines, zinc oxide, arbutin, retinol, retinol palmitate) contained in these compositions in the kits (1) to (3) is preferably in a ratio to the total amount of the two agents similar to the preferred ratio of these specific ingredients to 100 parts by mass of the topical skin preparation described above.

[0086] <Other ingredients> The skin external preparation of the present invention can use one or more of other active ingredients, preservatives, pH adjusters, oils and fats, fragrances, colorants, antioxidants, antibacterial and antifungal agents, alcohols, surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants, inorganic salts, lubricants, and solvents, which are generally used in skin external preparations. These are contained in the composition for skin external preparations of the present invention. In addition, in the kit of the present invention, the added ingredients can be used in either the first agent or the second agent, or in both agents.

[0087] In the topical skin preparation, kit, and composition for topical skin preparation of the present invention, the total content of other components (water, acidic substances, carbon dioxide generating substances, thickeners, polyhydric alcohols, and components other than the specific components) is preferably 30% by mass or less, and more preferably 25% by mass or less.

[0088] <Kit dosage form and ingredient amount> The kits (1) to (3) are described in more detail. In the kits (1) to (3), the aqueous composition of each kit (the acid-containing composition of the kit (1), the base-containing composition of the kit (2), and the aqueous composition of the kit (3)) may be in the form of a gel or liquid. The other agent in each kit (the base-containing composition of the kit (1), the acid-containing composition of the kit (2), and the acid- and base-containing composition of the kit (3)) may be in the form of a solid, liquid, gel, or the like. In the case of a solid form, it is preferable that the agent is in the form of granules, fine grains, or powder from the viewpoints of ease of mixing with the other agent and production costs.

[0089] <Water-containing composition of kits (1) to (3)> The preferred amounts of the carbon dioxide gas generating substance, the acidic substance and the specific component in the water-containing composition of the kits (1) to (3) are as described above. The water content in the water-containing composition of the kits (1) to (3) is preferably 20% by mass or more, particularly 30% by mass or more, from the viewpoint of mixability with the other components of each kit, and is preferably 95% by mass or less, particularly 90% by mass or less, from the viewpoint of enhancing the cosmetic effect of the skin topical agent by containing other components.

[0090] When the hydrous composition of the kits (1) to (3) contains a polyhydric alcohol, the proportion of the polyhydric alcohol in the hydrous composition is preferably 1% by mass or more, particularly 10% by mass or more, from the viewpoint of enhancing the moisturizing effect by combining with a specific component, etc., and is preferably 90% by mass or less, particularly 80% by mass or less, and especially 70% by mass or less, from the viewpoint of enhancing the cosmetic effect as a topical skin preparation by containing other components.

[0091] In addition, each of the water-containing compositions (1) to (2) preferably contains the above-mentioned acidic substance, carbon dioxide gas generating substance, and specific component in the above-mentioned amounts. In addition, each of the water-containing compositions (1) to (3) may contain moisturizing agents other than polyhydric alcohols, surfactants, pH adjusters, volatile alcohols, oils and fats, fragrances, animal and plant extracts, etc. For example, moisturizing agents other than polyhydric alcohols include polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidone carboxylate, almond, avocado, althea, aloe, mallow, ononis, oat, licorice, quince seed, sophora jasmine, gardenia, grapefruit, watercress, gentiana, geranium herb, burdock, wheat, saishin, cactus, soapwort, hawthorn, rehmannia, meadowsweet, ginger. , mallow, mulberry, thyme, cordyceps, houttuynia, peppermint, Job's tears, witch hazel, rose, cypress, coltsfoot, grape, prune, loofah, linden, hops, pine, quince, horse chestnut, melissa, cornflower, lily, lime, lavender, apple, rice and rice bran, blackcurrant, Ibuki no yarrow, Rosa multiflora, Eleuthero, seaweed, and other plant extracts can be used alone or in combination.

[0092] The liquid agent preferably has a viscosity of less than 5000 mPa·s at 25°C, more preferably less than 4000 mPa·s. The gel agent preferably has a viscosity of 5000 Pa·s or more at 25°C. This viscosity is measured, for example, by a viscometer (RVT model manufactured by Brookfield). The amount of thickener in the liquid agent is preferably less than 0.05% by mass, more preferably less than 0.01% by mass, and particularly preferably less than 0.005% by mass. On the other hand, the amount of thickener in the gel agent is preferably 0.01% by mass or more, more preferably 0.05% by mass or more.

[0093] <(1) The base-containing composition of the kit, (2) The acid-containing composition of the kit, and (3) The acid- and base-containing composition of the kit> The preferred amounts of the acid, carbon dioxide gas generating substance, and specific component in these compositions are as described above. When these compositions are solid, the preferred amount and content of the thickener is 0.01% by mass or more and 20% by mass or less, particularly 0.05% by mass or more and 15% by mass or less in these compositions when the other agent is in a gel state, from the viewpoints of good foaming, carbon dioxide gas retention, and the exertion of the effects of the specific component, and when the other agent is in a liquid state, the preferred amount and content of the thickener is 0.01% by mass or more and 30% by mass or less, particularly 0.05% by mass or more and 25% by mass or less in these compositions, from the viewpoints of easy mixing with the liquid agent, foaming, carbon dioxide gas retention, and the exertion of the effects of the specific component.

[0094] As described above, the base-containing composition of the kit (1), the acid-containing composition of the kit (2), and the acid- and base-containing composition of the kit (3) may be in a gel or liquid form. In this case, the preferred amount of thickener in these compositions is the same as the preferred amount of the liquid or gel thickener in the water-containing composition of the kits (1) to (3) described above. In addition, when the base-containing composition of the kit (1), the acid-containing composition of the kit (2), and the acid- and base-containing composition of the kit (3) are in a gel or liquid form, the proportion of water in these compositions is 7% by mass or more, particularly 10% by mass or more, and especially 20% by mass or more. is preferable from the viewpoint of foaming property and bubble persistence, and 95% by mass or less, particularly 90% by mass or less is preferable from the viewpoint of enhancing the cosmetic effect as an external skin preparation containing other ingredients.

[0095] When the base-containing composition of the kit (1), the acid-containing composition of the kit (2), and the acid- and base-containing composition of the kit (3) contain a polyhydric alcohol and these compositions are in a gel or liquid form, the content of the polyhydric alcohol in these compositions is preferably 1% by mass or more, particularly 10% by mass or more, from the viewpoint of ease of use during use, and is preferably 90% by mass or less, particularly 80% by mass or less, and especially 70% by mass or less, from the viewpoint of containing other components and enhancing the cosmetic effect as a skin topical agent. When the base-containing composition of the kit (1), the acid-containing composition of the kit (2), and the acid- and base-containing composition of the kit (3) are in a gel or liquid form, other components contained in these compositions include surfactants, preservatives, pH adjusters, fragrances, colorants, antioxidants, antibacterial and antifungal agents, etc.

[0096] When the base-containing composition of the kit (1), the acid-containing composition of the kit (2), or the acid- and base-containing composition of the kit (3) is solid, the following method can be used for granulating it into granules.

[0097] When granules are obtained by granulating a mixture of an acidic substance and / or a carbon dioxide gas generating substance with other components, the content of the other components is not particularly limited, but is preferably less than 95% by mass in the granules. If the other components are present in an amount exceeding 95% by mass, the foaming property is reduced, which is not preferred. The method for producing the powder or granules is not limited to that in this embodiment, and they can be produced by a conventional method such as a dry crushing granulation method, a wet crushing granulation method, a fluidized bed granulation method, a high speed stirring granulation method, or an extrusion granulation method.

[0098] For example, in the production of granules, a matrix base material having a function of forming granules may be used. When a low melting point compound is used as the matrix base material, the carbon dioxide gas generating substance is added to the low melting point compound that has been melted by heating in a container such as a beaker, and the mixture is thoroughly stirred and mixed. If necessary, suitable additives may be added to this. This is gradually cooled at room temperature while being further stirred, and left to stand until it solidifies. Once it has solidified to a certain extent, it may be rapidly cooled in a refrigerator or the like.

[0099] Alternatively, for example, the above materials may be charged into a fluidized bed granulator, mixed with an air current for several minutes, and then granulated by spraying water thereon.

[0100] When a low melting point compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide gas generating substance is dissolved or dispersed in this and mixed thoroughly, and then the mixture is heated in an oven or the like to remove the solvent and dried. Once completely solidified, it is pulverized and sieved to make the particle size uniform, and then made into granules.

[0101] The shape of the acidic substance and / or carbon dioxide gas generating substance can be, for example, irregular, planar, polyhedral, spherical, teardrop, fibrous, cylindrical, fine powder, etc., without any particular limitation. In addition, a wide range of particle sizes can be used without any particular limitation. In particular, from the viewpoints of ease of handling and ease of mixing with the viscous composition, those with a particle size distribution of about 1,000 μm or less are more preferable. The particle size distribution in the present invention can be determined by a conventional laser diffraction / scattering method.

[0102] The acidic substance and / or carbon dioxide gas generating substance may be blended together with the components contained in the same agent as they are, or may be blended together so as not to come into physical contact with other components in the same agent and coexist. In this case, for example, a coating layer may be provided on either or both of the acidic substance and / or carbon dioxide gas generating substance and the other components to encase them, or either or both of the carbon dioxide gas generating substance and the other components may be encapsulated. In addition, the acidic substance and / or carbon dioxide gas generating substance may be compression molded by sandwiching a layer that does not contain the carbon dioxide gas generating substance, the acidic substance, and other components between each other component or between other components so that they do not come into direct contact with each other. Known methods can be used as a means for making the acidic substance and / or carbon dioxide gas generating substance and other components coexist in the same agent.

[0103] When the kits (1) to (3) each contain both water-containing compositions, the mixing ratio (mass ratio) of the two is preferably 1:0.1 or more and 20 or less, and more preferably 1:0.2 or more and 10 or less. When the kits (1) to (3) each contain both a water-containing composition and a composition that does not substantially contain water (for example, a composition in which the proportion of water is 5 mass % or less), the mixing ratio (mass ratio) of the two is preferably 1:0.01 or more and 30 or less, and more preferably 1:0.05 or more and 20 or less.

[0104] The amounts of the acidic substance, carbon dioxide gas-generating substance, thickener, water and specific component used in the topical skin preparation of the present invention (or used in mixing to obtain a carbon dioxide gas-containing topical skin preparation) are preferably 0.1 to 15 mass% for the acidic substance, 0.1 to 20 mass% for the carbon dioxide gas-generating substance, 0.1 to 20 mass% for the thickener, 40 to 99.6 mass% for water and 0.01 to 30 mass% for the specific component, relative to the total amount. When the topical skin preparation contains a polyhydric alcohol, the amounts of the acidic substance, carbon dioxide gas generating substance, thickener, water, specific component, and polyhydric alcohol used in the topical skin preparation (or used in mixing to obtain a carbon dioxide gas-containing topical skin preparation) are preferably 0.1 to 10 mass% for the acidic substance, 0.1 to 10 mass% for the carbon dioxide gas generating substance, 0.1 to 15 mass% for the thickener, 30 to 97 mass% for the water, 0.01 to 20 mass% for the specific component, and 0.05 to 50 mass% for the polyhydric alcohol, relative to the total amount. The amounts of these components can be obtained as the amounts in a kit for obtaining the topical skin preparation or a composition for topical skin preparation, or the amount of water to be mixed with the composition.

[0105] <Usage form of the composition for topical skin preparation> The composition for skin external preparation of the present invention may be in any form such as solid, liquid, gel, etc., but in terms of ease of mixing with other agents and cost during production, a solid form is preferred, and among solid forms, granular, fine granular, and powder forms are more preferred. When using the composition for skin external preparation, foaming occurs by mixing with a water-containing substance on the palm of the hand or in a container. Examples of the water-containing substance used include water-containing liquids that are usually used in cosmetics, medicines, etc., or used in ordinary households. The water-containing liquid may be water itself. Specifically, examples include tap water, distilled water, membrane-filtered water, ion-exchanged water, deep sea water, as well as alcoholic beverages such as sake and wine, soy milk, drinking yogurt, acerola juice, sports drinks, carbonated water, rice water, etc. These may be used alone or in a mixture of two or more.

[0106] The amount of the water-containing substance used is not particularly limited and can be used in a wide range, but for example, it is preferable to add 1 to 10 times the mass of the skin topical preparation, and more preferably 2 to 5 times the mass. By adding more than 1 times the amount of liquid, the skin topical preparation can be quickly dissolved and a sufficient amount of carbon dioxide gas can be generated. On the other hand, by adding the liquid within 10 times the amount, dripping due to a decrease in the viscosity of the skin topical preparation can be prevented.

[0107] The temperature of the water-containing substance to be used is not particularly limited and can be used in a wide range, but it is particularly preferable to cool it before use, since the effect of carbon dioxide gas can be enhanced by the action of a specific component contained in the skin external preparation. From the viewpoint of the feeling of use during application and the convenience of the user, it is preferable to use water or tap water at about room temperature.

[0108] When the composition for skin external preparation or the component of the kit is a solid, the method of storing the kit is not particularly limited as long as it is stored in a state that is protected from moisture and does not come into contact with the skin. The shape of the storage container used can be appropriately selected according to the purpose, and includes cup-shaped, tube-shaped, bag-shaped, bottle-shaped, stick-shaped, pump-shaped, jar-shaped, canned, etc. In addition, the material that constitutes the storage container can be, for example, plastic, glass, aluminum, paper, various polymers, etc., alone or in combination of two or more kinds, but is not limited thereto.

[0109] Specific examples of containers that are preferable in terms of airtightness, storage stability of the contents, production costs, etc. include storage containers such as aluminum sticks and aluminum bags whose inner surface is laminated with polyethylene terephthalate, stand pouches with zippers, and storage containers made of polyethylene terephthalate whose lids are heat-sealed with aluminum films whose inner surface is laminated with polyethylene terephthalate, etc.

[0110] <Uses of topical skin preparations> The skin topical preparation of the present invention promotes an increase in skin blood flow due to the action of carbon dioxide gas. The skin topical preparation of the present invention has excellent skin-improving effects, such as whitening the skin color, increasing the skin moisture content, reducing the amount of water evaporation, and improving skin elasticity. In addition, the skin topical preparation of the present invention has excellent usability during use (ease of mixing, smoothness of foam, fineness of foam, uniformity of foam, ease of application, resistance to dripping, foam elasticity, carbonation and its duration, etc.), and excellent usability after use (skin moistness, elasticity, brightness, redness, smoothness, smoothness, tightening, etc.). In addition, the skin topical preparation of the present invention promotes skin metabolism (turnover). Furthermore, the skin topical preparation of the present invention contains a specific active ingredient in a carbon dioxide gas foaming skin topical preparation, and has a skin cell activating effect, and can be used as a skin cell activating agent. In addition, the skin topical preparation of the present invention has an activation effect on skin metabolism and an ATP production promoting effect due to cell activating effect. Taking advantage of these effects, the topical skin preparation of the present invention has the following properties: whitening, improving skin quality, improving freckles, rejuvenating the skin, tightening the skin, slimming spots, cleansing the skin, conditioning the skin, improving skin texture, keeping the skin healthy, preventing rough skin, tightening the skin, moisturizing the skin, replenishing and maintaining the skin's moisture and oil content, maintaining the skin's flexibility, protecting the skin, preventing the skin from drying out, softening the skin, making the skin firm, giving the skin a lustrous look, smoothing the skin, preventing age spots and freckles caused by sunburn, and reducing dryness. The present invention can be suitably used not only in cosmetics intended to make fine wrinkles caused by aging less noticeable, but also in quasi-drugs and pharmaceuticals such as medicines intended to prevent rough skin, chapped skin, heat rash, chilblains, cracks, chapped skin, acne, oily skin, razor burn, spots and freckles caused by sunburn, hot flashes after sunburn and snowburn, tightening the skin, cleaning the skin, conditioning the skin, keeping the skin healthy, moisturizing the skin, protecting the skin, preventing dryness of the skin, etc. The skin topical preparation of the present invention is preferably used as a cosmetic or quasi-drug, and is preferably used as cosmetics or medicinal cosmetics such as emulsions, creams, packs, and peeling agents. In particular, when used as a pack agent, it is preferred because it has a good feel when used and is easy to achieve a high skin condition improvement effect.

[0111] The present invention also provides a carbon dioxide gas foaming topical skin preparation (carbon dioxide gas-containing composition) obtained by mixing an acidic substance, a carbon dioxide gas generating substance that reacts with the acidic substance to generate carbon dioxide gas, a thickener, and water, and further comprising the above-mentioned specific component. EXAMPLES

[0112] The present invention will be described in more detail below with reference to examples, but the scope of the present invention is not limited to these examples. In the following examples and comparative examples, the raw materials used are commercially available products unless otherwise specified. The arbutin used below is β-arbutin.

[0113] <Production of foaming skin preparation> The components shown in Tables 1 to 6 were mixed to obtain the compositions shown in the tables to produce kits for external skin preparations in each Example and Comparative Example. In each Example and Comparative Example shown in Tables 1 to 6, preparations not containing water were in powder form, preparations containing water and a thickener were in gel form, and preparations containing water but no thickener were in liquid form. In addition, the components shown in Table 7 below were mixed to prepare a powdered composition for external use on the skin. The skin preparations obtained by mixing the A and B agents of each of the Examples shown in Tables 1 to 6 in the amounts shown in Tables 1 to 6 were easy to apply to the skin and easy to use. In addition, they provided a cosmetic effect to the skin after use. The same was true for the skin preparation obtained by mixing the composition for skin preparations shown in Table 7 with 9 g of the composition and 27 g of water as shown in Table 7. In Tables 1 to 7, the acidic substance is also simply called "acid", and the carbon dioxide gas generating substance is also simply called "carbonate". Glucose listed in "Other" also includes use as a polyhydric alcohol.

[0114] [Table 1]

[0115] [Table 2]

[0116] [Table 3]

[0117] [Table 4]

[0118] [Table 5]

[0119] [Table 6]

[0120] [Table 7]

[0121] The following [Evaluation 1] was carried out for each of the above examples and comparative examples. [Rating 1] Two healthy women in their 20s and 30s were randomly selected as subjects. The inside of the forearm of each subject was washed with a facial cleanser and allowed to rest for 15 minutes in the measurement room. Next, the color difference, water evaporation rate, stratum corneum moisture content, and elasticity were measured for a 4 cm x 4 cm measurement area on the inside of the forearm where the foaming skin topical agent was to be applied, using the following method. Next, the foaming skin topical agent was applied to the measurement site and left to stand for 10 minutes. Thereafter, the foaming skin topical agent was removed and washed with water. 15 minutes after washing, the same measurements were performed after using the foaming skin topical agent. The subjects rested in the measurement room during the measurements. The results of measuring the skin condition after use are shown in Figures 1A to 13B. The values ​​in Figures 1A to 13B are relative values ​​(rate of change) when the measured value before use of the foaming topical skin preparation is set to 1. A larger color difference value indicates a whiter skin color, a smaller water evaporation value indicates a better result with a well-established barrier function, a larger stratum corneum moisture value indicates a better skin condition, and a larger elasticity value indicates a better skin condition.

[0122] The skin condition before and after application of the foaming skin preparation was measured using the following devices, according to the standard method described in the instruction manual attached to each device. Color difference: Measured using a color difference meter (Konica Minolta CR-400). Water evaporation rate: Measured using a Tevameter (registered trademark) TM300 (CK Corporation). - Stratum corneum moisture content: Measured using a skin epidermal stratum corneum moisture content measuring device SKICON-200EX (manufactured by IBS Co., Ltd.) This skin epidermal stratum corneum moisture content measuring device evaluates the skin's conductance (electrical conductivity, unit: μS) as the moisture content of the stratum corneum. Elasticity: Measured using a skin elasticity measuring device, Cutometer MPA580 (manufactured by Courage+Khazaka).

[0123] As shown in Figures 1A to 13B, the foaming skin topical preparations of each Example containing a specific ingredient showed a greater increase in color difference, stratum corneum moisture content, and elasticity from before use, and a smaller decrease in water evaporation rate, compared to the foaming skin topical preparations of each Comparative Example not containing the specific ingredient. Therefore, it is clear that the foaming skin topical preparation of the present invention containing a specific ingredient has a high skin condition improving effect.

[0124] The following [Evaluation 2] was carried out for each of the above examples and comparative examples. [Evaluation 2] Three healthy women in their 20s and 30s were randomly selected as subjects. The inside of the forearm of each subject was washed with a facial cleanser and allowed to rest for 15 minutes in the measurement room. Next, the foaming skin preparation was applied to the measurement site on the inside of the forearm and left to stand for 10 minutes. Next, the foaming skin preparation was removed and washed with water. Evaluation items (16 items) during and after use were evaluated based on a 7-point evaluation scale. The evaluation criteria are shown in Table A below, and the results are shown in Tables B to G below. The results below are the average of the evaluation points of the three subjects.

[0125] [Table A]

[0126] [Table B]

[0127] [Table C]

[0128] [Table D]

[0129] [Table E]

[0130] [Table F]

[0131] [Table G]

[0132] As shown in Tables B to G, the foaming skin topical preparations of each Example containing a specific component are superior in usability during use (ease of mixing, smoothness of foam, fineness of foam, uniformity of foam, ease of application, resistance to dripping, foam elasticity, carbonation and its duration) compared with the foaming skin topical preparations of each Comparative Example not containing the specific component, and are also superior in usability after use (skin moistness, elasticity, brightness, redness, smoothness, smoothness, firmness).Therefore, it is clear that the foaming skin topical preparation of the present invention containing a specific component has a high skin condition improving effect, and can whiten, improve skin quality, tighten skin, condition skin, condition skin texture, tighten skin, moisturize skin, maintain skin flexibility, soften skin, give skin firmness, smooth skin, and make fine wrinkles caused by dryness less noticeable.

[0133] The following [Evaluation 3] was carried out for each of the above examples and comparative examples. [Evaluation 3] (Turnover test) The subject (a randomly selected healthy woman in her 20s to 30s) washed the inside of her forearm with face wash and rested for 15 minutes in the measurement room. Next, cellophane tape (4cm x 1.8cm) was applied to the measurement site on the inside of the forearm, pressed firmly with a certain amount of pressure, and then the tape was peeled off. This operation was repeated twice. The foaming skin topical agent after mixing was applied to an area of ​​4cm x 4cm on the measurement site and left to stand for 10 minutes. Next, the foaming skin topical agent was removed and washed with water. Five minutes later, the same tape application and peeling operation was repeated twice on the measurement site other than the area where the tape was applied before application. The first piece of tape was discarded, and a thin layer of polyvinyl chloride resin adhesive was spread on the stratum corneum collection surface of the second piece of tape, and the tape was attached to a glass slide. After attachment, the glass slide was thoroughly dried, then immersed in ethanol for 10 minutes, and dried at room temperature (22°C to 27°C) for at least 10 minutes. The tape was then immersed in xylene until it peeled off. After the tape was removed, the slide was further removed for 30 minutes to 1 hour. The slide glass was immersed in xylene. The slide glass was taken out, dried, and then immersed in a staining solution (0.1 w / w% gentian violet and 0.5 w / w% brilliant green dissolved in purified water) for 15 minutes. After washing 4 to 5 times with purified water, it was dried and observed at 200x magnification under an optical microscope. The obtained observation images were evaluated according to the evaluation criteria shown in Table H below. The three items shown in Table H below were evaluated on a five-point scale. The total score (score: 5 to 1 point) for the three items was calculated for the images observed before and after use of the foaming skin topical preparation, and the total score before use was subtracted from the total score after use to obtain a value. All three items in Table H below indicate the degree of skin metabolism (turnover), and the higher the score, the greater the degree of turnover. The difference in the total score obtained above before and after use is shown in Figures 14 to 26. Furthermore, the images of stratum corneum cells obtained by the above-mentioned microscopic observation before and after use of the foaming skin topical preparations of Comparative Example 1, Examples 1-19, Examples 2-3, and Examples 4-3 are shown in Figure 27.

[0134] [Table H]

[0135] As shown in Fig. 14 to Fig. 26, in each Example containing a specific component, the total score value after use of the foaming skin topical preparation increased by 2 or more from before use. On the other hand, in Comparative Examples 1 to 7, the total score value after use of the foaming skin topical preparation decreased from before use, or even if it increased, the difference from before use was only 1 or less. Also, from Fig. 27, it is clear that the improvement in the stratum corneum morphology and arrangement regularity, which are indicators of turnover, from before use after use of the foaming skin topical preparation is remarkable in the Examples, but not in the Comparative Examples. Therefore, it is clear that the foaming skin topical preparation of each Example has a superior effect of promoting turnover compared to each Comparative Example.

[0136] The specific component used in the present invention was subjected to a cell activation test according to the following procedures (1) to (5). [Cell activation test 1] (1) 37°C, 5% CO by volume 2 75cm in the incubator 2 Using flasks, normal Human dermal fibroblasts (NHDF) were cultured in Dulbecco's modified Eagle medium containing 10% by mass of fetal bovine serum (10% by mass FBS-DMEM). (2) The cells cultured in (1) were suspended by trypsinization and then cultured in a 75 cm 2 Fras 1 × 10 4 The cells were seeded at a density of 100 cells / well. (3) The cells seeded in (2) were incubated in 10% FBS-DMEM medium at 37°C and 5% CO 2 The cells were pre-cultured in an incubator for 24 hours. (4) After the pre-culture in (3), the medium was removed from each well, and the wells were washed once with 200 μL / well of serum-free DMEM, and then 200 μL of medium containing a test substance adjusted to a predetermined concentration was added to each well. After addition of the medium containing the test substance, the cells were incubated at 37°C with 5% CO by volume. 2 The cells were cultured in an incubator for 24 hours. The test substance-containing medium was prepared according to Preparation Method 1 below. (Preparation method 1 of medium containing test substance) Sodium bicarbonate, malic acid, a thickener shown in Table 8 below, and arbutin as a specific component were mixed with serum-free DMEM so that the final concentration of sodium bicarbonate was 62.5 mM, the final concentration of malic acid was 20.8 mM, and the final concentrations of the thickener and specific component were the values ​​shown in Table 8 below.

[0137] [Table 8]

[0138] (5) After culturing, the cells were washed once with 200 μL / well of PBS. Cell Counting Kit-8 solution diluted 30-fold with serum-free DMEM was added at 150 μL / well. After that, the plates were incubated at 37°C and 5% CO 2After allowing the plate to stand in an incubator to allow appropriate color development, the absorbance at 450 nm was measured. The cell activation activity (%) was calculated based on the obtained absorbance using the following formula. In the following formula, the data from Reference Example 1 was used as the data control. Cell activation activity (%)=(Data sample-Data blank) / (Data control-Data blank)×100

[0139] The results of the cell-activating activity are shown in Figure 28. As shown in Figure 28, it is clear that the cell-activating activity can be enhanced by combining a specific component with a thickener, an acidic component, and a carbon dioxide gas generating component.

[0140] In addition, the specific components shown in Table 9 below were subjected to the following [Cell Activation Test 2]. [Cell activation test 2] The preparation method of the medium containing the test substance was changed to the following preparation method 2. In addition, when calculating the cell activation activity (%), serum-free DMEM without the test substance was used as a data control. Other than these points, the same procedure as in the above [Cell activation test 1] was followed. The results are shown in Table 9 below. (Preparation method 2 of medium containing test substance) The specific components shown in Table 9 below were mixed with serum-free DMEM to give final concentrations shown in Table 9 below. When the "carbonate" column in Table 9 below reads "present," both the specific components were mixed with serum-free DMEM to give final sodium bicarbonate concentrations of 31.2 mM and final malic acid concentrations of 6.25 mM. When the "carbonate" column in Table 9 below reads "-," only the specific component was mixed with serum-free DMEM, and neither sodium bicarbonate nor malic acid was used.

[0141] [Table 9]

[0142] As described above, it was confirmed that the cell activation activity of the foaming topical skin preparation containing a specific ingredient is enhanced.

Claims

1. A one-component foamable skin preparation for external use, which contains an acidic substance, a carbonate, and a thickener, and further contains at least one selected from ascorbic acid-2-glucoside and tranexamic acid, and is characterized in that the foamable skin preparation for external use is mixed with a water-containing substance when used.

2. A foamable topical skin preparation as described in claim 1, which promotes cell turnover or stimulates cells.

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