Beauty Methods

Abstract

To provide a cosmetic method for improving permeability of niacin amide.SOLUTION: A cosmetic method includes applying an external preparation for skin 1 containing the following (A)-(E) and then applying an external preparation for skin 2 containing the following (F)-(H): (A) glycerol, (B) polyoxyalkylene alkyl glucoside, (C) phosphorylcholine group-containing polymer, (D) highly polymerized polyethylene glycol, (E) Tremella fuciformis polysaccharide, (F) niacin amide, (G) Leontopodium alpinum extract, and (H) Lamium album var. barbatum extract.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a cosmetic method that improves the penetration of niacinamide. [Background technology]

[0002] As humans age, various aging phenomena such as age spots, wrinkles, and sagging skin appear. These are known to be caused by a decrease in the skin's barrier function, a decrease in moisture content, disturbances in turnover, and a decrease in the production or decomposition or alteration of collagen and elastin. A wide variety of proposals have been made to prevent and improve these phenomena (Patent Document 1, Patent Document 2, Patent Document 3).

[0003] Niacinamide is a water-soluble vitamin that is one of the B vitamins and is also called nicotinamide. It is known for its effects of improving rough skin, whitening, and anti-aging, and many cosmetics containing niacinamide are on the market.

[0004] Various studies have been conducted on skin preparations that exhibit anti-aging effects by combining niacinamide with specific plant extracts (Patent Document 4). However, there remain issues regarding the permeability of niacinamide. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Patent No. 4780817 [Patent Document 2] JP 2001-261568 A [Patent Document 3] JP 2005-8571 A [Patent Document 4] Patent Application No. 2020-141481 Summary of the Invention [Problem to be solved by the invention]

[0006] An object of the present invention is to provide a cosmetic method that improves the permeability of niacinamide. [Means for solving the problem]

[0007] A cosmetic method comprising applying an external skin preparation 1 containing the following (A) to (E) and then applying an external skin preparation 2 containing the following (F) to (H). (A) Glycerin (B) Polyoxyalkylene alkyl glucoside (C) Phosphorylcholine group-containing polymer (D) Highly polymerized polyethylene glycol (E) Tremella fuciformis polysaccharide (F) Niacinamide (G) Edelweiss Extract (H) Lamium extract Effect of the Invention

[0008] The cosmetic method of the present invention has the effect of improving the permeability of niacinamide. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The cosmetic method of the present invention involves applying an external skin preparation 1 containing the following (A) to (E) and then applying an external skin preparation 2 containing the following (F) to (H). (A) Glycerin (B) Polyoxyalkylene alkyl glucoside (C) Phosphorylcholine group-containing polymer (D) Highly polymerized polyethylene glycol (E) Tremella fuciformis polysaccharide (F) Niacinamide (G) Edelweiss Extract (H) Lamium extract

[0010] Hereinafter, an embodiment of the present invention will be described.

[0011] [Glycerin] The glycerin to be blended in the external skin preparation 1 used in the cosmetic method of the present invention is not particularly limited with respect to its raw materials, production method, purification method, etc., so long as it is one that is usually used in external skin preparations.

[0012] In the present invention, the blending amount of glycerin is preferably 1 to 40% by mass, more preferably 1 to 25% by mass, based on the total amount of the external skin preparation.

[0013] [Polyoxyalkylene alkyl glucoside] The polyoxyalkylene alkyl glucoside to be blended in the skin topical preparation 1 used in the cosmetic method of the present invention can be, for example, an alkyl glucoside to which one or two alkylene oxides selected from ethylene oxide and propylene oxide have been added, and the average number of moles added is preferably about 1 to 30 moles. The alkyl group in the polyoxyalkylene alkyl glucoside is preferably one having 1 to 4 carbon atoms, and preferred examples include a methyl group, an ethyl group, a propyl group, and an isopropyl group. Preferred specific examples of polyoxyalkylene alkyl glucoside include polyoxyalkylene methyl glucoside, and more specifically, POE(10) methyl glucoside, POE(20) methyl glucoside, POP(10) methyl glucoside, and POP(20) methyl glucoside. Of these polyoxyalkylene alkyl glucosides, it is most preferred to use POE(10) methyl glucoside from the viewpoint of good compatibility with the skin. In this specification, polyoxyethylene is abbreviated as POE, polyoxypropylene is abbreviated as POP, and the number in parentheses is the average number of moles added. Commercially available products include MacBiobride MG-10E, MacBiobride MG-20E, MacBiobride MG-10P (all manufactured by NOF Corp.), GLUCAME-10LFG, and GLUCAMEP-10 (all manufactured by LUBRIZOL ADVANCED MATERIALS).

[0014] In the present invention, the blending amount of the polyoxyalkylene alkyl glucoside is preferably 0.0001 to 20% by mass, more preferably 0.001 to 5% by mass, based on the total amount of the external skin preparation.

[0015] [Polymer containing phosphorylcholine group] The phosphorylcholine group-containing polymer to be blended in the skin topical preparation 1 used in the cosmetic method of the present invention may be any polymer that can be blended in a skin topical preparation. One type may be used alone, or two or more types may be used in combination. Specific examples of such phosphorylcholine group-containing polymers include, as cosmetic ingredient names, polyquaternium-51 (2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer), polyquaternium-65 (2-methacryloyloxyethylene phosphorylcholine-butyl methacrylate-sodium methacrylate copolymer), polyquaternium-64 (2-methacryloyloxyethyl phosphorylcholine-2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer), polyquaternium-61 (2-methacryloyloxyethyl phosphorylcholine-stearyl methacrylate copolymer), etc. In the present invention, it is preferable to use polyquaternium-51 from the viewpoint of effect. Commercially available products include LIPIDURE-PMB and LIPIDURE-B (both manufactured by NOF Corporation).

[0016] In the present invention, the blending amount of the phosphorylcholine group-containing polymer is preferably 0.00001 to 5% by mass, more preferably 0.00001 to 1% by mass, based on the total amount of the external skin preparation.

[0017] [Highly polymerized polyethylene glycol] The highly polymerized polyethylene glycol to be blended in the skin external preparation 1 used in the cosmetic method of the present invention is exemplified by the cosmetic labeling names PEG-100, PEG-135, PEG-150, PEG-180, PEG-200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-450, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-18M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, etc. Among these, it is more preferable to use PEG-150 in terms of the effects of the present invention. Examples of commercially available products include PEG 6000 and PEG 6000P (both manufactured by NOF Corporation).

[0018] In the present invention, the blending amount of highly polymerized polyethylene glycol is preferably 0.01 to 10 mass %, more preferably 0.1 to 5 mass %, based on the total amount of the external skin preparation.

[0019] [Tremendous fungus polysaccharide] The Tremella fuciformis polysaccharide contained in the external skin preparation 1 used in the cosmetic method of the present invention is a water-soluble polysaccharide extracted with a solvent from a mushroom belonging to the Tremellaceae family.

[0020] Examples of the extraction solvent include water, lower alcohols such as ethanol, and polyhydric alcohols such as 1,3-butylene glycol and dipropylene glycol. These solvents may be used alone or in combination. Among these, it is preferable to use water, hot water, or a solvent that can be mixed with water in any ratio, such as a mixture of ethanol and 1,3-butylene glycol, and it is more preferable to use hot water. The extraction method is not particularly limited, but an example of the method is mixing the extraction solvent and Tremella fuciformis and extracting it by heating. The obtained extract can be used as it is, or it can be used after being appropriately concentrated or dried into a powder by spray drying or freeze drying.

[0021] Commercially available products can also be used, such as Tremoist-TP, Tremoist-SL (manufactured by Nippon Fine Chemicals), White Jew's Jew's Polysaccharide-P (manufactured by Oryza Oil & Fat Chemical), and HyaCare Tremella (manufactured by Evonik Japan).

[0022] The amount of Tremella fuciformis polysaccharide blended in the present invention is preferably 0.00001 to 3 mass %, more preferably 0.00005 to 2 mass %, in terms of pure Tremella fuciformis polysaccharide content, relative to the total amount of the external skin preparation.

[0023] [Niacinamide] Niacinamide, which is incorporated into the external skin preparation 2 used in the cosmetic method of the present invention, is one of the B vitamins, which are water-soluble vitamins, and is also called nicotinamide.

[0024] The niacinamide used in the present invention is not particularly limited with respect to its raw material, production method, purification method, etc., so long as it is one that is usually used in external skin preparations.

[0025] The blending amount of niacinamide in the present invention is 0.001 to 20 mass %, preferably 0.01 to 15 mass %, and more preferably 0.1 to 10 mass %, based on the total amount of the external skin preparation 2.

[0026] [Edelweiss] Edelweiss (scientific name: Leontopodium alpinum) is an alpine plant belonging to the Leontopodium genus of the Asteraceae family.

[0027] The edelweiss extract to be incorporated in the skin topical preparation 2 used in the cosmetic method of the present invention can be one that is usually incorporated in skin topical preparations. It is possible to use one directly extracted from the plant, or a commercially available edelweiss extract. Examples of commercially available edelweiss extracts include EDELWEISS GC (Albaflor), EDELWEISS EP, and EDELWEISS B (all from DSM Nutrition Japan).

[0028] The blending amount of the edelweiss extract in the present invention is preferably 0.00001 to 5 mass %, more preferably 0.00001 to 1 mass %, based on the total amount of the external skin preparation 2.

[0029] Examples of parts of edelweiss that can be used include leaves, stems, flowers, buds, and the whole above-ground plant, with the whole above-ground plant being preferred.

[0030] [Lamb's Lamium] Lamium album (scientific name: Lamium album) is a perennial plant classified in the Lamium genus of the Lamiaceae family.

[0031] The dead nettle extract to be incorporated in the external skin preparation 2 used in the cosmetic method of the present invention may be one that is usually incorporated in external skin preparations. Either one extracted directly from the plant or a commercially available dead nettle extract may be used. An example of a commercially available dead nettle extract is Falcorex dead nettle B (Ichimaru Falcos Co., Ltd.).

[0032] The amount of the Lamium extract in the present invention is preferably 0.00001 to 5 mass %, more preferably 0.00001 to 1 mass %, based on the total amount of the external skin preparation 2.

[0033] Examples of parts of Lamium that can be used include leaves, stems, flowers, buds, and the whole aboveground plant, with the whole aboveground plant being preferred.

[0034] When preparing the extract to be incorporated in the skin external preparation 2, the raw plant is used as it is or after drying. As the extraction solvent, water, lower alcohols such as methanol, ethanol, propanol, isopropanol, etc., polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin, etc., ethers such as ethyl ether, propyl ether, etc., esters such as ethyl acetate, butyl acetate, etc., ketones such as acetone, ethyl methyl ketone, etc., and polar organic solvents can be used, and one or more of these can be selected and used. In addition, physiological saline, phosphate buffer, phosphate buffered physiological saline, etc. may be used. The extract using the above solvent can be used as it is, but it may also be concentrated, dried, and dissolved again in water or a polar solvent, or it may be used after purification treatment such as bleaching, deodorization, desalting, etc., within the range that does not impair the skin physiological function improving effect, or after fractionation treatment by column chromatography. In addition, the extract may be hydrolyzed using an acid, alkali, enzyme, etc. and used. For storage, it can also be freeze-dried after purification treatment and dissolved in a solvent when used. It can also be used by being encapsulated in a vesicle such as a liposome or a microcapsule. The extraction process is not particularly limited as long as the soluble components contained in the extraction raw material can be dissolved in the extraction solvent, and can be performed according to a conventional method. For example, the extraction raw material is immersed in an extraction solvent in an amount 5 to 30 times (mass ratio) of the extraction raw material, and the soluble components are extracted at room temperature or under reflux heating, and then the extraction residue is removed by filtration to obtain an extract. The solvent is distilled off from the obtained extract to obtain a paste-like concentrate, and the concentrate is further dried to obtain a dry product.

[0035] In addition to the above-mentioned components, optional components used in ordinary cosmetics and quasi-drugs can be blended into the skin topical preparation used in the cosmetic method of the present invention to the extent that they do not impair the effects of the present invention.Specific examples of such components include ultraviolet absorbing agents, ultraviolet scattering agents, oils, surfactants, thickening agents, preservatives, fragrances, colorants, moisturizing agents, antioxidants, anti-inflammatory agents, and antibacterial agents.

[0036] The formulation of the external skin preparation used in the cosmetic method of the present invention is not particularly limited, and may be any formulation such as water-based, oil-based, or emulsion-type.

[0037] The skin external preparation used in the cosmetic method of the present invention can be prepared by a standard method. EXAMPLES

[0038] The present invention will be described in detail below with reference to examples, but the scope of the present invention is not limited thereto. In the following examples, the blending amounts are shown in mass % unless otherwise specified.

[0039] First, a method for preparing the plant extract used in the external skin preparation 2 will be described.

[0040] [Edelweiss extract] The dried edelweiss aerial parts were immersed in 70% by volume of ethanol aqueous solution, and the filtrate was concentrated and the solvent was removed by distillation. The edelweiss extract was prepared by adding the extract to 55% by volume of glycerin so that the extract was 7.5% by mass in terms of pure content.

[0041] [Lamb's Lamium Extract] The dried above-ground parts of Lamium amplexicaule were immersed in 50% by volume of 1,3-butylene glycol, filtered, and the solvent was removed by distillation. Lamium amplexicaule extract was prepared by adding 1% by mass of pure extract to 50% by volume of 1,3-butylene glycol.

[0042] According to the formulations shown in Tables 1 and 2, topical skin preparations 1 and 2 used in the cosmetic method of the present invention were prepared by conventional methods.

[0043] [Table 1]

[0044] [Table 2]

[0045] [Niacinamide permeability test] The skin permeability of niacinamide in the skin topical preparation 2 was evaluated using a Franz cell. A Strat-M (registered trademark) membrane for transdermal diffusion tests (manufactured by Merck) was used as the permeation membrane, and the skin topical preparation 1 was applied at a concentration of 2 μL / cm 2 After applying the mixture evenly with a finger so that the amount of the skin topical preparation 2 was 10 mL, this was used as Example 1, and the other comparative example was used as Comparative Example 1. After 1 hour, the niacinamide concentration (ppm) in the receptor solution was measured for each method. The results are shown in Table 3.

[0046] [Table 3]

[0047] As shown in Table 3, the penetration of niacinamide was improved by 3.7 times by using a cosmetic method in which topical skin preparation 1 was applied followed by topical skin preparation 2, compared to the application of only topical skin preparation 2.

Claims

[Claim 1] A cosmetic method comprising applying an external skin preparation 1 containing the following (A) to (E) and then applying an external skin preparation 2 containing the following (F) to (H). (A) Glycerin (B) Polyoxyalkylene alkyl glucoside (C) Phosphorylcholine group-containing polymer (D) Highly polymerized polyethylene glycol (E) Tremella fuciformis polysaccharide (F) Niacinamide (G) Edelweiss extract (H) Lamium extract

Images