MicroRNA-containing body fluid extracts

Abstract

The present disclosure provides a body fluid extract containing micro RNA. According to the present disclosure, an extract of body fluid containing any of the micro RNA described in data S1 or table 2, or in any of tables 4-1 to 4-15, is provided.

Description

[Technical Field]

[0001] The present disclosure relates to body fluid extracts containing microRNAs. [Background technology]

[0002] MicroRNAs (miRNAs) contained within extracellular vesicles (hereinafter simply referred to as "EVs"), such as exosomes, microvesicles, and apoptotic bodies (Non-Patent Documents 1-4), have been found in various bodily fluids, including those of healthy individuals and diseased patients (Non-Patent Documents 6-20). Differences in EV-encapsulated miRNAs between two human groups may be a warning sign of various diseases (Non-Patent Document 20). The incorporation of miRNAs into EVs is thought to have the advantage of reducing the effect of ribonucleases on RNA degradation (Non-Patent Document 21), and miRNAs in EVs are thought to be more stable than free, floating miRNAs.

[0003] To date, three methods have been used to recover EVs: ultracentrifugation or differential centrifugation, immunoaffinity-based capture, and size-exclusion chromatography (Non-Patent Document 4). Promising alternative methods have been reported, including polymer precipitation (Non-Patent Document 22), microfluidic platforms (Non-Patent Documents 23-26), and size-based filtration (Non-Patent Document 27). However, these existing methods for recovering EV-encapsulated miRNAs are insufficient for recovering EVs from urine, which contains EVs at very low concentrations (<0.01% by volume) (Non-Patent Document 28). For example, ultracentrifugation is the most commonly used method for recovering urinary EVs. Ultracentrifugation has identified 200–300 miRNAs in urine (Non-Patent Documents 29–31). Over 2,000 human miRNAs have been reported. However, it remains unclear whether the remaining 90% are present in urine. [Prior art documents] [Non-patent literature]

[0004] [Non-licensed document 1] G. Raposo, W. Stoorvogel, J. Cell Biol. 200, 373-383 (2013). [Non-licensed document 2] I. Evans-Osses, LHR Eichembach, MI, Parasitol. Res. 114, 3567-3575 (2015). [Non-licensed document 3] P.Ma,Y.et al.,J.Hematol.Oncol.10,57(2017).

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Summary of the Invention

[0005] The present disclosure provides a body fluid extract containing microRNA.

[0006] The present inventors have found that contacting a solution containing extracellular vesicles (EVs) with positively charged nanowires (nanorods) in solution (particularly at the pH of urine) can efficiently capture EVs onto the nanowires. The inventors have also found that contacting urine with the nanowires effectively captures EVs and miRNAs in urine, thereby enabling the production of urine extracts containing miRNAs that could not be extracted using conventional methods. Furthermore, by analyzing urine samples from patients with various diseases, the inventors have successfully detected various miRNAs that were not previously thought to be detected in urine or urine extracts. These miRNAs may be useful as predictive markers for disease status, etc. The present disclosure is based on this finding.

[0007] According to the present disclosure, the following industrially applicable inventions can be provided. (1) A urine extract comprising the following (i) to (xvi): (i) any microRNA listed in Data S1 or Table 2 ; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Table 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4-15; A urine extract comprising a microRNA selected from the group consisting of: (2) A urine extract according to (1) above, which contains extracellular vesicles, and the microRNA is contained in the extracellular vesicles, or the microRNA is extracted from the extracellular vesicles. (3) The urine extract described in (1) above, wherein the RNA is in the form of free microRNA. (4) MicroRNAs include miR-3117-5p, miR-3118, miR-3121-3p, miR-3121-5p, miR-3126-5p, miR-3128, miR-3133, mi R-3134, miR-3136-3p, miR-3136-5p, miR-3139, miR-3142, miR-3143, miR-3145-3p, miR-3163, miR-3166, m iR-3167, miR-16-1-3p, miR-424-3p, miR-519c-5p, miR-525-5p, miR-551b-5p, miR-558, miR-921, miR-942 -3p, miR-3126-3p, miR-3127-5p, miR-3129-5p, miR-3144-5p, miR-3150a-5p, miR-3152-5p, miR-3155a, miR -3157-3p, miR-3159, miR-3165, miR-3678-3p, miR-4321, miR-4521, miR-4800-3p, miR-4999-5p, miR-5096 , miR-5187-5p, miR-6874-5p, miR-3127-3p, miR-3130-5p, miR-3131, miR-3141, miR-3150b-5p, miR-3151- The urine extract according to any one of (1) to (3) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-3150a-3p, miR-3162-5p, miR-3151-5p, miR-3154, miR-3160-3p, miR-3160-5p, miR-378a-5p, miR-520c-3p, miR-526b-3p, miR-3150a-3p, miR-3162-5p, and miR-4254. (5) A urine extract according to any one of (1) to (4) above, wherein the microRNA is at least one microRNA selected from the group consisting of miR-3163, miR-16-1-3p, miR-424-3p, miR-558, miR-3127-5p, and miR-4521, or all microRNAs. (6) A urine extract according to any one of (1) to (4) above, wherein the microRNA is at least one microRNA selected from the group consisting of miR-378a-5p, miR-520c-3p, and miR-526b-3p, or all microRNAs. (7) The urine extract according to any one of (1) to (6) above, wherein the urine is urine from a subject with lung cancer. (8)RNA, let-7i-3p, miR-183-5p, miR-202-5p, miR-409-5p, miR-4661-5p, miR-4800-3p, miR-5587-5p, miR-372-3p, miR-378b, miR-520b, miR- 1266-3p、miR-3605-5p、miR-3612、miR-4645-3p、miR-4694-3p、miR-4752、miR-6816-3p、miR-8087、let-7f-2-3p、miR-15a-3p、miR-20a-3p、miR-33b- 3p、miR-34c-5p、miR-93-5p、miR-130a-5p、miR-135a-5p、miR-135b-5p、miR-185-5p、miR-203a-3p、miR-302d-5p、miR-337-3p、miR-378c、miR-422a、m iR-449c-5p、miR-483-5p、miR-506-3p、miR-511-5p、miR-520c-3p、miR-654-3p、miR-668-5p、miR-670-5p、miR-671-3p、miR-744-3p、miR-1178-3p、mi R-1254, miR-1284, miR-1323, miR-2116-5p, miR-2355-3p, miR-3132, miR-3138, miR-3164, miR-3186-3p, miR-3189-3p, miR-3198, miR-3200-5p, miR -3657、miR-3667-5p、miR-3680-5p、miR-3692-5p、miR-3713、miR-3921、miR-3936、miR-4273、miR-4299、miR-4306、miR-4316、miR-4319、miR-4421、mi R-4429、miR-4435、miR-4441、miR-4473、miR-4506、miR-4633-5p、miR-4658、miR-4733-5p、miR-4733-3p、miR-5004-3p、miR-5194、miR-5197-5p、miR- 5571-5p、miR-6083、miR-6717-5p、miR-6720-5p、miR-6767-3p、miR-6781-3p、miR-6811-3p、miR-6821-3p、miR-6828-5p、miR-6832-5p、miR-6837-3p、The urine extract according to any one of (1) to (3) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-6841-5p, miR-6853-5p, miR-6871-3p, miR-6875-5p, miR-6878-5p, miR-7112-3p, miR-7703, miR-7848-3p, and miR-7856-5p. (9) The urine extract according to (8) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-183-5p, miR-202-5p, and miR-409-5p. (10) The urine extract according to (8) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-372-3p, miR-520b, miR-15a-3p, miR-34c-5p, miR-135a-5p, miR-185-5p, miR-337-3p, miR-422a, miR-506-3p, miR-520c-3p, miR-1284, miR-1323, and miR-4273. (11) The urine extract according to any one of (8) to (10) above, wherein the urine is urine from a subject with pancreatic cancer. (12)MiR-4521, let-7c-3p, let-7i-5p, miR-16-1-3p, miR-26a-1-3p, miR-28-5p, miR-105-5p, miR-195-3p, miR-200b-5p, miR-219a-2-3 p, miR-297, miR-300, miR-330-3p, miR-374b-5p, miR-431-5p, miR-454-5p, miR-513c-5p, miR-548ax, miR-593-5p, miR-623, miR-664a-5p, miR-942- The urine extract according to any one of (1) to (3) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-1205, miR-1276, miR-1288-3p, miR-1297, miR-3678-3p, miR-4283, miR-4295, miR-4439, miR-4524b-5p, miR-4703-3p, miR-4768-5p, miR-4800-3p, miR-5187-5p, miR-5696, miR-7161-5p, let-7i-2-3p, and miR-520c-3p. (13) The urine extract according to (12) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-16-1-3p, miR-28-5p, miR-297, miR-300, miR-330-3p, miR-454-5p, miR-1297, and miR-4295. (14) The urine extract according to (12) above, wherein the microRNA is miR-520c-3p. (15) The urine extract according to any one of (12) to (14) above, wherein the urine is urine from a subject with liver cancer. (16) MicroRNAs are miR-16-1-3p, miR-23b-3p, miR-28-5p, miR-92a-2-5p, miR-142-3p, miR-195-3p, miR- 196b-5p, miR-299-3p, miR-492, miR-513b-5p, miR-601, miR-619-5p, miR-1285-3p, miR-3155a, miR-31 The urine extract according to any one of (1) to (3) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-62-5p, miR-3678-3p, miR-4283, miR-4295, miR-4311, miR-4531, miR-5096, miR-5187-5p, let-7f-2-3p, miR-520c-3p, and miR-4783-5p. (17) The urine extract according to (16) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-16-1-3p, miR-23b-3p, miR-28-5p, miR-142-3p, miR-195-3p, miR-299-3p, and miR-4295. (18) The urine extract according to (16) above, wherein the microRNA is miR-520c-3p. (19) The urine extract according to any one of (16) to (18) above, wherein the urine is urine from a subject with bladder cancer. (20)MiR-4531, miR-28-5p, miR-103a-2-5p, miR-105-5p, miR-124-3p, miR-151a-5p, miR-151b, miR-200a-5p, m iR-300, miR-424-3p, miR-519c-5p, miR-551b-5p, miR-617, miR-873-3p, miR-921, miR-1288-3p, miR-3124-5p, miR-3155a The urine extract according to any one of (1) to (3) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-3917, miR-4283, miR-4727-3p, miR-5096, miR-5187-5p, miR-6074, miR-6874-5p, miR-6892-5p, miR-15a-3p, miR-135b-5p, miR-520c-3p, miR-4783-5p, and miR-7849-3p. (21) The urine extract according to (20) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-28-5p, miR-105-5p, miR-124-3p, miR-151a-5p, and miR-300. (22) The urine extract according to (20) above, wherein the microRNA is at least one or all of the microRNAs selected from the group consisting of miR-15a-3p and miR-520c-3p. (23) The urine extract according to any one of (20) to (22) above, wherein the urine is urine from a subject with prostate cancer. (24) The urine extract according to any one of (1) to (6), (8) to (10), (12) to (14), (16) to (18), and (20) to (22), wherein the urine is urine from a healthy subject. (25) A method for testing the possibility that a subject has cancer, comprising: A method comprising one or more selected from the group consisting of the following (a) to (e): (a) detecting at least one microRNA selected from the group consisting of miR-3163, miR-16-1-3p, miR-424-3p, miR-558, miR-3127-5p, and miR-4521, or all microRNAs, in urine or a urine extract obtained from the subject, wherein an amount of the microRNA higher than a predetermined value indicates that the subject may have lung cancer; (b) detecting at least one or all of the microRNAs selected from the group consisting of miR-183-5p, miR-202-5p, and miR-409-5p in urine or a urine extract obtained from the subject, wherein an amount of the microRNA higher than a predetermined value indicates that the subject may have pancreatic cancer; (c) detecting at least one or all of the microRNAs selected from the group consisting of miR-16-1-3p, miR-28-5p, miR-297, miR-300, miR-330-3p, miR-454-5p, miR-1297, and miR-4295 in urine or a urine extract obtained from the subject, wherein an amount of the microRNA higher than a predetermined value indicates that the subject may have liver cancer; (d) detecting in urine or a urine extract obtained from the subject at least one or all of the microRNAs selected from the group consisting of miR-16-1-3p, miR-23b-3p, miR-28-5p, miR-142-3p, miR-195-3p, miR-299-3p, and miR-4295, wherein an amount of the microRNA higher than a predetermined value indicates that the subject may have bladder cancer; (e) detecting at least one or all of the microRNAs selected from the group consisting of miR-28-5p, miR-105-5p, miR-124-3p, miR-151a-5p, and miR-300 in urine or a urine extract obtained from the subject, wherein an amount of the microRNA higher than a predetermined value indicates that the subject may have prostate cancer. (26) The method according to (25) above, A method comprising one or more selected from the group consisting of (A) to (E): (A) further detecting at least one microRNA selected from the group consisting of miR-378a-5p, miR-520c-3p, and miR-526b-3p, or all microRNAs, in urine or a urine extract obtained from the subject in (a), wherein a lower amount of the microRNA than a predetermined value indicates that the subject may have lung cancer; (B) further detecting at least one or all of the microRNAs selected from the group consisting of miR-372-3p, miR-520b, miR-15a-3p, miR-34c-5p, miR-135a-5p, miR-185-5p, miR-337-3p, miR-422a, miR-506-3p, miR-520c-3p, miR-1284, miR-1323, and miR-4273 in the urine or urine extract obtained from the subject in (b), wherein a lower amount of the microRNA than a predetermined value indicates that the subject may have pancreatic cancer; (C) further detecting miR-520c-3p in urine or a urine extract obtained from the subject in (c), wherein a level of the microRNA lower than a predetermined value indicates that the subject may have liver cancer; (D) further detecting miR-520c-3p in urine or a urine extract obtained from the subject in (d), wherein an amount of the microRNA lower than a predetermined value indicates that the subject may have bladder cancer; (E) further detecting at least one or all of the microRNAs selected from the group consisting of miR-15a-3p and miR-520c-3p in the urine or urine extract obtained from the subject in (e), wherein if the amount of the microRNA is lower than a predetermined value, it indicates that the subject may have prostate cancer. (27) A urine extract obtained by contacting nanowires with urine and extracting components bound to the nanowires. (27a) The urine extract according to (27) above, wherein the pH of the urine to be contacted with the nanowires is in a range of 2, 3, 4, or 5 as the lower limit and 11, 10, 9, 8, 7, 6, or 5 as the upper limit. (27b) The urine extract according to (27) or (27a) above, wherein the nanowires are metal oxide nanowires or nanowires whose surfaces are coated with metal oxide. (27c) The urine extract according to (27b) above, wherein the metal oxide is an oxide of a transition metal. (27d) A urine extract according to (27), (27a), (27b) or (27c) above, wherein the nanowires are zinc oxide nanowires or nanowires coated with zinc oxide. (27e) The urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, wherein the nanowires are contacted with urine under neutral pH conditions. (28) A urine extract described in (27) above, containing any of the microRNAs listed in Data S1 or Table 2. (29) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, which contains vesicles that account for 20% or more of the extracellular vesicles contained in urine. (29') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 25% or more of the extracellular vesicles contained in urine. (29a) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 30% or more of the extracellular vesicles contained in urine. (29a') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 35% or more of the extracellular vesicles contained in urine. (29b) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 40% or more of the extracellular vesicles contained in urine. (29b') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 45% or more of the extracellular vesicles contained in urine. (29c) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 50% or more of the extracellular vesicles contained in urine. (29c') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 55% or more of the extracellular vesicles contained in urine. (29d) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 60% or more of the extracellular vesicles contained in urine. (29d') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing vesicles that account for 65% or more of the extracellular vesicles contained in urine. (29e) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 70% or more extracellular vesicles contained in urine. (29e') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 75% or more of the extracellular vesicles contained in urine. (29f) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 80% or more of the extracellular vesicles contained in urine. (29f') A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 85% or more of the extracellular vesicles contained in urine. (29g) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 90% or more of the extracellular vesicles contained in urine. (29h) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 95% or more of the extracellular vesicles contained in the urine. (29i) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, containing 97% or more of the extracellular vesicles contained in urine. (29j) A urine extract according to (27), (27a), (27b), (27c), (27d) or (27e) above, which contains 99% or more of the extracellular vesicles contained in urine. (30) The urine extract according to (1) above, containing the enriched microRNA. (31) A urine extract containing over 500 types of microRNAs present in urine. (31A) A urine extract according to (1) or (31) above, containing 500 or more types of microRNA present in urine.

[0008] According to the present disclosure, the following further industrially applicable inventions are provided. (1) A urine extract containing one or more microRNAs selected from the group consisting of: hsa-let-7a-3p、hsa-miR-103a-2-5p、hsa-miR-103a-3p、hsa-miR-105-3p、hsa-miR-106a-3p、hsa-miR-1180-3p、hsa-miR-1185-2-3p、hsa-miR-11 93, hsa-miR-127-3p, hsa-miR-1245b-5p, hsa-miR-1247-3p, hsa-miR-125b-2-3p, hsa-miR-1263, hsa-miR-173g-3p, hsa-miR-129-2-3p, hsa-miR-1 293、hsa-miR-1301-5p、hsa-miR-130a-3p、hsa-miR-130a-5p、hsa-miR-1469、hsa-miR-149-5p、hsa-miR-152-5p、hsa-miR-15b-3p、hsa-miR-16-1- 3p、hsa-miR-181a-3p、hsa-miR-184、hsa-miR-186-5p、hsa-miR-18a-5p、h sa-miR-193b-3p、hsa-miR-200a-3p、hsa-miR-200c-5p、hsa-miR-208b-5p hsa-miR-216a-3p, hsa-miR-7b-5p, hsa-miR-2861, hsa-miR-2909, hsa-miR-298, hsa-miR-29a-5p, hsa-miR-302b-3p, hsa-miR-30b-3p, hsa-miR- 30d-5p、hsa-miR-3116、hsa-miR-3122、hsa-miR-3125、hsa-miR-3126-3p、hsa-miR-3129-3p、hsa-miR-3130-3p、hsa-miR-3133、hsa-miR-3136-3p、h sa-miR-3137, hsa-miR-3143, hsa-miR-3150a-3p, hsa-miR-3174, hsa-miR-3177-5p, hsa-miR-3179, hsa-miR-3180, hsa-miR-3186-3p, hsa-miR-318 6-5p、hsa-miR-3187-3p、hsa-miR-3189-3p、hsa-miR-3190-3p、hsa-miR-3190-5p、hsa-miR-3194-5p、hsa-miR-3195、hsa-miR-3197、hsa-miR-3198、hsa-miR-3200-5p、hsa-miR-320a、hsa-miR-320c、hsa-miR-320d、hsa-miR-323b-5p、hsa-miR-324-3p、hsa-miR-325、hsa-miR-32-5p、hsa-miR-329- 3p、hsa-miR-331-3p、hsa-miR-331-5p、hsa-miR-335-3p、hsa-miR-337-3p、hsa-miR-337-5p、hsa-miR-33a-3p、hsa-miR-33a-5p、hsa-miR-342-3p、h sa-miR-345-5p、hsa-miR-346、hsa-miR-34a-5p、hsa-miR-3606-3p、hsa-miR-3607-5p、hsa-miR-3613-3p、hsa-miR-3613-5p、hsa-miR-361-3p、hsa- miR-3616-3p, hsa-miR-3616-5p, hsa-miR-3621, hsa-miR-3622a-5p, hsa-miR-363-3p, hsa-miR-3658, hsa-miR-3659, hsa-miR-367-3p, hsa-miR-367 4、hsa-miR-3678-3p、hsa-miR-3681-5p、hsa-miR-3683、hsa-miR-3684、hsa-miR-3690、hsa-miR-374c-5p、hsa-miR-376a-3p、hsa-miR-376a-5p、hsa -miR-376b-3p、hsa-miR-384、hsa-miR-3913-3p、hsa-miR-3940-3p、hsa-miR-3960、hsa-miR-3976、hsa-miR-4269、hsa-miR-477、hsa-miR-4302、hsa -miR-4303、hsa-miR-4304、hsa-miR-4307、hsa-miR-4316、hsa-miR-4319、hsa-miR-432-3p、hsa-miR-432-5p、hsa-miR-4326、hsa-miR-4421、hsa-mi R-4433b-5p、hsa-miR-4456、hsa-miR-4472、hsa-miR-4479、hsa-miR-4521、hsa-miR-4639-5p、hsa-miR-4646-5p、hsa-miR-4660、hsa-miR-4662a-3p、hsa-miR-4688, hsa-miR-4694-3p, hsa-miR-4695-3p, hsa-miR-4695-5p, hsa-miR-4699-3p, hsa-miR-4701-5p, hsa-miR-4704-3p, hsa-miR-4716-5 p、hsa-miR-4719、hsa-miR-4721、hsa-miR-4724-5p、hsa-miR-4736、hsa-miR-4738-3p、hsa-miR-4740-3p、hsa-miR-4750-5p、hsa-miR-4753-5p、hsa -miR-4759、hsa-miR-4776-5p、hsa-miR-4778-3p、hsa-miR-4793-5p、hsa-miR-4796-5p、hsa-miR-4799-3p、hsa-miR-4804-5p、hsa-miR-487b-5p、hs a-miR-497-5p, hsa-miR-5008-3p, hsa-miR-5011-5p, hsa-miR-509-5p, hsa-miR-514a-3p, hsa-miR-514b-5p, hsa-miR-515-3p, hsa-miR-518f-3p, h sa-miR-5194, hsa-miR-525-3p, hsa-miR-541-3p, hsa-miR-548aa, hsa-miR-548t-3p, hsa-miR-548ae-3p, hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548o-5p, hsa-miR-548am-5p, hsa-miR-548f-5p, hsa-miR-548j-3p, hsa-miR-548n, hsa-miR-548v, hsa-miR-548x-3p, hsa-miR-548z, hsa-miR -548h-3p、hsa-miR-549a、hsa-miR-5571-5p、hsa-miR-5572、hsa-miR-5580-5p、hsa-miR-5586-3p、hsa-miR-5586-5p、hsa-miR-561-3p、hsa-miR-57 1, hsa-miR-574-3p, hsa-miR-578, hsa-miR-582-3p, hsa-miR-593-5p, hsa-miR-598-3p, hsa-miR-601, hsa-miR-606, hsa-miR-6068, hsa-miR-6077hsa-miR-6083, hsa-miR-6089, hsa-miR-6090, hsa-miR-6132, hsa-miR-6133, hsa-miR-616-5p, hsa- miR-617, hsa-miR-620, hsa-miR-622, hsa-miR-623, hsa-miR-625-5p, hsa-miR-626, hsa-miR-636, h sa-miR-642b-5p, hsa-miR-649, hsa-miR-6504-5p, hsa-miR-6508-3p, hsa-miR-6511b-3p, hsa-miR- 6513-5p, hsa-miR-651-5p, hsa-miR-6516-5p, hsa-miR-652-3p, hsa-miR-661, hsa-miR-664a-3p, hs a-miR-664a-5p, hsa-miR-665, hsa-miR-671-3p, hsa-miR-6715b-3p, hsa-miR-6720-5p, hsa-miR-67 21-5p, hsa-miR-6726-3p, hsa-miR-6734-3p, hsa-miR-6735-5p, hsa-miR-6742-3p, hsa-miR-6755-3 p, hsa-miR-6760-3p, hsa-miR-6767-5p, hsa-miR-6777-5p, hsa-miR-6782-5p, hsa-miR-6890-3p, hs a-miR-8084, hsa-miR-888-3p, hsa-miR-92b-5p, hsa-miR-935, hsa-miR-93-5p, and hsa-miR-942-3p. , (2) The urine extract according to (1) above, containing one or more microRNAs selected from the group consisting of: hsa-miR-103a-3p, hsa-miR-1193, hsa-miR-127-3p, hsa-miR-1247-3p, hsa-miR-1263, hsa-miR-173g-3p, hsa-miR-129-2-3p, hsa-miR-1293, hsa- miR-130a-5p, hsa-miR-1469, hsa-miR-15b-3p, hsa-miR-193b-3p, hsa-miR-2861, hsa-miR-298, hsa-miR-30d-5p, hsa-miR-3122, hsa-miR-3137 sa-miR-3174, hsa-miR-3177-5p, hsa-miR-3186-3p, hsa-miR-3187-3p, hsa-miR-3189-3p, hsa-miR-3190-5p, hsa-miR-3194-5p, hsa-miR-3198, hsa-miR-320c, hsa-miR-329-3p, hsa-miR-337-3p, hsa-miR-337-5p, hsa-miR-33a-3p, hsa-miR-345-5p, hsa-miR-346, hsa-miR-34a-5p, hsa-miR-361 3-3p, hsa-miR-361-3p, hsa-miR-3616-3p, hsa-miR-3622a-5p, hsa-miR-363-3p, hsa-miR-3659, hsa-miR-3678-3p, hsa-miR-3681-5p, hsa-miR-37 4c-5p、hsa-miR-3960、hsa-miR-3976、hsa-miR-4269、hsa-miR-4304、hsa-miR-4307、hsa-miR-432-3p、hsa-miR-4433b-5p、hsa-miR-4456、hsa-miR- 4472, hsa-miR-4479, hsa-miR-4521, hsa-miR-4646-5p, hsa-miR-4694-3p, hsa-miR-4699-3p, hsa-miR-4701-5p, hsa-miR-4719, hsa-miR-4721, hs a-miR-4724-5p、hsa-miR-4776-5p、hsa-miR-4796-5p、hsa-miR-4804-5p、hsa-miR-5011-5p、hsa-miR-509-5p、hsa-miR-515-3p、hsa-miR-5571-5p、hsa-miR-5580-5p, hsa-miR-574-3p, hsa-miR-578, hsa-miR-582-3p, hsa-miR-598-3p, hsa-miR-6068, hsa-miR-6 077, hsa-miR-6089, hsa-miR-6133, hsa-miR-616-5p, hsa-miR-622, hsa-miR-626, hsa-miR-636, hsa-miR-6504-5p , hsa-miR-6516-5p, hsa-miR-661, hsa-miR-664a-3p, hsa-miR-6715b-3p, hsa-miR-6720-5p, hsa-miR-6734-3p, h sa-miR-6742-3p, hsa-miR-6760-3p, hsa-miR-6767-5p, hsa-miR-6777-5p, hsa-miR-6890-3p, and hsa-miR-93-5p. , (3) The urine extract according to (1) above, containing one or more microRNAs selected from the group consisting of: hsa-miR-103a-2-5p, hsa-miR-1193, hsa-miR-3622a-5p, hsa-miR-363-3p, hsa-miR-4521, hsa-miR-4796-5p, hsa-miR-518f-3p, hsa-miR-5580-5p sa-miR-3125, hsa-miR-3130-3p, hsa-miR-3678-3p, hsa-miR-4750-5p, hsa-miR-5194, hsa-miR-578, hsa-miR-625-5p, hsa-miR-6755-3p, hsa-miR-1 293, hsa-miR-3137, hsa-miR-4646-5p, hsa-miR-514b-5p, hsa-miR-598-3p, hsa-miR-200c-5p, hsa-miR-3150a-3p, hsa-miR-3186-3p, hsa-miR-3187 -3p、hsa-miR-3189-3p、hsa-miR-4303、hsa-miR-320a、hsa-miR-4421、hsa-miR-515-3p、hsa-miR-665、hsa-miR-6767-5p、hsa-miR-6782-5p、hsa-miR -3659、hsa-miR-3690、hsa-miR-4721、hsa-miR-4776-5p、hsa-miR-622、hsa-miR-2909、hsa-miR-3200-5p、hsa-miR-323b-5p、hsa-miR-34a-5p、hsa-m iR-4688, hsa-miR-3190-3p, hsa-miR-3613-3p, hsa-miR-4793-5p, hsa-miR-6083, hsa-miR-4316, hsa-miR-4738-3p, hsa-miR-5572, hsa-miR-661, hs a-miR-3116, hsa-miR-3621, hsa-miR-4326, hsa-miR-623, hsa-miR-6504-5p, hsa-miR-1301-5p, hsa-miR-487b-5p, hsa-miR-3126-3p, hsa-miR-4304 hsa-miR-3186-5p, hsa-miR-342-3p, hsa-miR-4695-3p, hsa-miR-5008-3p, hsa-miR-616-5p, hsa-miR-125b-2-3p, hsa-miR-4479, hsa-miR-4740-3phsa-miR-103a-3p, hsa-miR-181a-3p, hsa-miR-337-5p, hsa-miR-1263, hsa-miR-374c-5p, hsa-miR-1180-3p, hsa-miR-29a-5p, hsa-miR-509-5p, hsa-miR-15b-3p, hsa-miR-32-5p, hsa-miR-376a-3p, hsa-miR-4804-5p, hsa-miR-5011-5p hsa-miR-582-3p, hsa-miR-320d, hsa-miR-130a-3p, hsa-miR-200a-3p, hsa-miR-4639-5p, hsa-miR-571, hsa-miR-33a-5p, hsa-miR-4719, hsa-miR-3681-5p, hsa-miR-4699-3p, hsa-miR-626, hsa-miR-105-3p, hsa-miR-384, hsa-miR-397 6, hsa-miR-186-5p, hsa-miR-18a-5p, hsa-miR-3616-5p, hsa-miR-4302, hsa-miR-548c-5p, hsa-miR-548o-5p, hsa-miR-548am-5p, hsa-miR-548v, hsa-let-7a-3p, hsa-miR-3143, hsa-miR-367-3p, hsa-miR-376a-5p, hsa-miR-548ae-3p sa-miR-5586-5p、hsa-miR-6715b-3p、hsa-miR-548aa、hsa-miR-548t-3p、hsa-miR-652-3p、hsa-miR-3607-5p、hsa-miR-3683、hsa-miR-477、hsa-miR-4704-3p、hsa-miR-4799-3p、hsa-miR-548x-3p、hsa-miR-549a、およびhsa-miR-6508-3p。、 The urine extract according to (1) above, comprising one or more microRNAs selected from the group consisting of: hsa-miR-103a-2-5p, hsa-miR-106a-3p, hsa-miR-1185-2-3p, hsa-miR-1193, hsa-miR-1273g-3p, hsa-miR-1293, hsa-miR-1301-5p, hsa-miR-152-5p, hsa-miR-184, hsa-miR-200c-5p, hsa-miR-2909, hsa-miR-298, hsa-miR-302b-3p, hsa-miR-3116, hsa-miR-3122, hsa-miR-3125, hsa-miR-3126-3p, hsa-miR-3129-3p, hsa-miR-3130-3p, hsa-miR-3133, hsa-miR-3137, hsa-miR-3150a-3p, hsa-miR-3174, hsa-miR-3177-5p, hsa-miR-3179, hsa-miR-3186-3p, hsa-miR-3186-5p, hsa-miR-3187-3p, hsa-miR-3189-3p, hsa-miR-3190-3p, hsa-miR-3200-5p, hsa-miR-320a, hsa-miR-320c, hsa-miR-323b-5p, hsa-miR-325, hsa-miR-331-5p, hsa-miR-335-3p, hsa-miR-33a-3p, hsa-miR-342-3p, hsa-miR-34a-5p, hsa-miR-3606-3p, hsa-miR-3616-3p, hsa-miR-3621, hsa-miR-3622a-5p, hsa-miR-3659, hsa-miR-3690, hsa-miR-376b-3p, hsa-miR-3913-3p, hsa-miR-4269, hsa-miR-4303, hsa-miR-4304, hsa-miR-4307, hsa-miR-4316, hsa-miR-4326, hsa-miR-4421, hsa-miR-4472, hsa-miR-4479, hsa-miR-4646-5p, hsa-miR-4660, hsa-miR-4688, hsa-miR-4695-3p, hsa-miR-4695-5p, hsa-miR-4721, hsa-miR-4724-5p, hsa-miR-4738-3p,hsa-miR-4740-3p,hsa-miR-4750-5p,hsa-miR-4753-5p,hsa-miR-4759,hsa-miR-4776-5p,hs a-miR-4778-3p,hsa-miR-4796-5p,hsa-miR-487b-5p,hsa-miR-5008-3p,hsa-miR-514b-5p,h sa-miR-518f-3p,hsa-miR-5194,hsa-miR-541-3p,hsa-miR-548c-3p,hsa-miR-548j-3p,hsa- miR-548n,hsa-miR-548z,hsa-miR-548h-3p,hsa-miR-5572,hsa-miR-5580-5p,hsa-miR-5586- 3p,hsa-miR-601,hsa-miR-6068,hsa-miR-6083,hsa-miR-6133,hsa-miR-617,hsa-miR-622,h sa-miR-625-5p,hsa-miR-649,hsa-miR-6504-5p,hsa-miR-6513-5p,hsa-miR-651-5p,hsa-miR -6516-5p,hsa-miR-661,hsa-miR-664a-5p,hsa-miR-665,hsa-miR-6755-3p,hsa-miR-6767-5 p, hsa-miR-6777-5p, hsa-miR-6782-5p, hsa-miR-8084, hsa-miR-888-3p, and hsa-miR-942-3p. , (5) A method for predicting the possibility of a subject having lung cancer, comprising: detecting in the subject's urine one or more microRNAs selected from the group consisting of: A method including predicting the possibility that the subject has cancer using the expression level of the microRNA as an index: hsa-miR-4443, hsa-miR-4515, hsa-miR-4743-5p, hsa-miR-1908-3p, hsa-miR-4314, hsa-miR-296-3p, hsa-miR-6772-5p, hsa-miR-370-3p, hsa-miR-4708-3p, hsa-miR-4499, hsa-miR-6759-5p, hsa-miR-3160-3p, hsa-miR-219a-2-3p, hsa-miR-564, hsa-miR-4269, hsa-let-7b-5p, hsa-miR-4535, hsa-miR-187-3p, hsa-miR-5588-3p, hsa-miR-194-3p, hsa-miR-3153, hsa-miR-3074-5p, hsa-miR-4721, hsa-miR-173h-5p, hsa-miR-1471, hsa-miR-936, hsa-miR-622, hsa-miR-3622a-5p, hsa-miR-4252, hsa-miR-4533, hsa-miR-3917, hsa-miR-520d-5p, hsa-miR-4639-3p, hsa-miR-4496, hsa-miR-3156-5p, hsa-miR-3689b-3p, hsa-miR-3689c, hsa-miR-4669, hsa-miR-6072, hsa-miR-6751-5p, hsa-miR-378b, hsa-miR-520b, hsa-miR-1307-3p, hsa-miR-8075, hsa-miR-4448, hsa-miR-4487, hsa-miR-5002-3p, hsa-miR-4518, hsa-miR-4769-5p, hsa-miR-4724-5p, hsa-miR-397-5p, hsa-miR-494-5p, hsa-miR-6884-5p, hsa-miR-6796-5p, hsa-miR-181b-3p, hsa-miR-526b-5p, hsa-miR-1226-5p, hsa-miR-6776-5p, hsa-miR-4529-3p, hsa-miR-7851-3p, hsa-miR-3189-3p, hsa-miR-5010-5p, hsa-miR-4638-5p, hsa-miR-3177-3phsa-miR-6872-5p, hsa-miR-6745, hsa-miR-6871-5p, hsa-miR-138-1-3p, hsa-miR-4539, hsa-miR-3652, hsa-miR-505-5p, hsa-miR-173g-3p, hsa-m iR-4701-3p, hsa-miR-3160-5p, hsa-miR-6815-5p, hsa-miR-6499-5p, hsa-miR-5589-5p, hsa-miR-4489, hsa-miR-212-5p, hsa-miR-5698, hsa-miR-3 124-5p、hsa-miR-3176、hsa-miR-3612、hsa-miR-6849-5p、hsa-miR-6760-5p、hsa-miR-6833-5p、hsa-miR-8077、hsa-miR-277-3p、hsa-miR-7975、hsa -miR-6859-5p、hsa-miR-3187-5p、hsa-miR-3145-5p、hsa-miR-3689a-3p、hsa-miR-4800-5p、hsa-miR-1224-5p、hsa-miR-193a-5p、hsa-miR-6076、hs a-miR-4260, hsa-miR-298, hsa-miR-34a-5p, hsa-miR-6131, hsa-miR-5708, hsa-miR-4776-3p, hsa-miR-378e, hsa-miR-3659, hsa-miR-3120-5p, hs a-miR-3122, hsa-miR-3177-5p, hsa-miR-4420, hsa-miR-323a-5p, hsa-miR-466, hsa-miR-276-3p, hsa-miR-3138, hsa-miR-6834-5p, hsa-miR-185-5 p、hsa-miR-2467-3p、hsa-miR-6847-5p、hsa-miR-608、hsa-miR-6504-5p、hsa-miR-3922-5p、hsa-miR-877-5p、hsa-miR-4307、hsa-miR-4512、hsa-mi R-6892-5p、hsa-miR-4776-5p、hsa-miR-3065-5p、hsa-miR-6129、hsa-miR-4676-5p、hsa-miR-603、hsa-miR-6876-5p、hsa-miR-4635、hsa-miR-4525、hsa-miR-1468-5p、hsa-miR-519c-5p、hsa-miR-523-5p、hsa-miR-518e-5p 、hsa-miR-522-5p、hsa-miR-519a-5p、hsa-miR-519b-5p、hsa-miR-4711-3p hsa-miR-1293, hsa-miR-6068, hsa-miR-1254, hsa-miR-4306, hsa-miR-3186-3p, hsa-miR-4691-5p, hsa-miR-1321, hsa-miR-4540, hsa-miR-6823-5 p、hsa-miR-3935、hsa-miR-5006-5p、hsa-miR-4756-3p、hsa-miR-4785、hsa-miR-8082、hsa-miR-6788-5p、hsa-miR-6500-3p、hsa-miR-5189-5p、hsa- miR-7151-3p, hsa-miR-891a-5p, hsa-miR-3126-5p, hsa-miR-8083, hsa-miR-4428, hsa-miR-4474-3p, hsa-miR-7850-5p, hsa-miR-4700-5p, hsa-miR -6828-5p、hsa-miR-668-5p、hsa-miR-3934-5p、hsa-miR-4654、hsa-miR-4436a、hsa-miR-173f、hsa-miR-3655、hsa-miR-650、hsa-miR-3137、hsa-miR -4285, hsa-miR-171-5p, hsa-miR-3064-3p, hsa-miR-6801-5p, hsa-miR-6817-5p, hsa-miR-4686, hsa-miR-173g-5p, hsa-miR-6807-3p, hsa-miR-674 7-5p、hsa-miR-5580-5p、hsa-miR-4796-5p、hsa-miR-3174、hsa-miR-7157-5p、hsa-miR-614、hsa-miR-4502、hsa-miR-3164、hsa-miR-4647、hsa-miR- 378i、hsa-miR-6515-5p、hsa-miR-656-5p、hsa-miR-449c-5p、hsa-miR-3591-3p、hsa-miR-424-3p、hsa-miR-3149、hsa-miR-6868-5p、hsa-miR-173d、hsa-miR-4644, hsa-miR-4754, hsa-miR-477-3p, hsa-miR-4445-3p, hsa-miR-4436b-3p, hsa-miR-4262, hsa-miR-1306-3p, hsa-miR-4514, hsa-miR-4296, hsa-miR-4458, hsa-miR-4520-5p, hsa-miR-766 -5p、hsa-miR-548ao-3p、hsa-miR-758-5p、hsa-miR-4451、hsa-miR-4300、hsa-miR-4453、hsa-miR-4784、hsa-miR-6809-5p、hsa-miR-4692、hsa-miR-4437、hsa-miR-4681、hsa-miR-921、hsa-miR-1250-5 p、hsa-miR-5093、hsa-miR-551b-5p、hsa-miR-4529-5p、hsa-miR-4538、hsa-miR-176、hsa-miR-1322、hsa-miR-473、hsa-miR-106a-5p、hsa-miR-297、hsa-miR-1910-3p、hsa-miR-4470、hsa-miR-3691-5p 、hsa-miR-4999-5p、hsa-miR-3192-5p、hsa-miR-548au-3p、hsa-miR-5007-5p、hsa-miR-4657、hsa-miR-4768-3p、hsa-miR-1265、hsa-miR-4321、hsa-miR-4423-5p、hsa-miR-1294、およびhsa-miR-4520-3p。、 (5A) The method according to (4) above, wherein the detected miRNA is one or more microRNAs selected from the group consisting of hsa-miR-6788-5p, hsa-miR-6500-3p, hsa-miR-5189-5p, hsa-miR-7151-3p, hsa-miR-891a-5p, hsa-miR-3126-5p, hsa-miR-8083, hsa-miR-4428, hsa-miR-4474-3p, hsa-miR-7850-5p, hsa-miR-4700-5p, hsa-miR-6828-5p, hsa-miR-668-5p, hsa-miR-3934-5p, hsa-miR-4654, hsa-miR-4436a, hsa-miR-173f, hsa-miR-3655, hsa-miR-650, hsa-miR-3137, hsa-miR-4285, hs a-miR-171-5p, hsa-miR-3064-3p, hsa-miR-6801-5p, hsa-miR-6817-5p, hsa-miR-4686, hsa-miR-173g-5p, hsa-miR-6807-3p, hsa-miR-6747-5p, hsa -miR-5580-5p, hsa-miR-4796-5p, hsa-miR-3174, hsa-miR-7157-5p, hsa-miR-614, hsa-miR-4502, hsa-miR-3164, hsa-miR-4647, hsa-miR-378i, hs a-miR-6515-5p, hsa-miR-656-5p, hsa-miR-449c-5p, hsa-miR-3591-3p, hsa-miR-424-3p, hsa-miR-3149, hsa-miR-6868-5p, hsa-miR-173d, hsa-miR -4644, hsa-miR-4754, hsa-miR-477-3p, hsa-miR-4445-3p, hsa-miR-4436b-3p, hsa-miR-4262, hsa-miR-1306-3p, hsa-miR-4514, hsa-miR-4296, hsa -miR-4458, hsa-miR-4520-5p, hsa-miR-766-5p, hsa-miR-548ao-3p, hsa-miR-758-5p, hsa-miR-4451, hsa-miR-4300, hsa-miR-4453, hsa-miR-4784,hsa-miR-6809-5p, hsa-miR-4692, hsa-miR-4437, hsa-miR-4681, hsa-miR-921, hsa-miR-1250-5p, hsa-miR-5093, hsa-miR-551b-5p, hsa-miR-4529-5p, hsa-miR-4538, hsa-miR-176, hsa-miR-1322, hsa-miR-473, hsa-miR-106a-5p, hsa-miR-297, hsa- miR-1910-3p, hsa-miR-4470, hsa-miR-3691-5p, hsa-miR-4999-5p, hsa-miR-3192-5p, hsa-miR-548au-3p, hsa-miR-5007-5p, hsa-miR-4657, hsa-miR-4768-3p, hsa-miR-1265, hsa-miR-4321, hsa-miR-4423-5p, hsa-miR-1294, hsa-miR-4520-3p. (5B) The method according to (4) above, wherein the detected miRNA is one or more microRNAs selected from the group consisting of hsa-miR-4644, hsa-miR-4754, hsa-miR-477-3p, hsa-miR-4445-3p, hsa-miR-4436b-3p, hsa-miR-4262, hsa-miR-1306-3p, hsa-miR-4514, and hsa-miR-4644. iR-4296, hsa-miR-4458, hsa-miR-4520-5p, hsa-miR-766-5p, hsa-miR-548ao-3p, hsa-miR-758-5p, hsa-miR- 4451, hsa-miR-4300, hsa-miR-4453, hsa-miR-4784, hsa-miR-6809-5p, hsa-miR-4692, hsa-miR-4437, hsa-miR -4681, hsa-miR-921, hsa-miR-1250-5p, hsa-miR-5093, hsa-miR-551b-5p, hsa-miR-4529-5p, hsa-miR-4538, hsa-miR-176, hsa-miR-1322, hsa-miR-473, hsa-miR-106a-5p, hsa-miR-297, hsa-miR-1910-3p, hsa-miR-4470 , hsa-miR-3691-5p, hsa-miR-4999-5p, hsa-miR-3192-5p, hsa-miR-548au-3p, hsa-miR-5007-5p, hsa-miR-46 57, hsa-miR-4768-3p, hsa-miR-1265, hsa-miR-4321, hsa-miR-4423-5p, hsa-miR-1294, and hsa-miR-4520-3p. (5C) The method described in (4) above, wherein the detected miRNA is one or more microRNAs selected from the group consisting of hsa-miR-4768-3p, hsa-miR-1265, hsa-miR-4321, hsa-miR-4423-5p, hsa-miR-1294, and hsa-miR-4520-3p. (5D) A method according to any one of (5), (5A), (5B), and (5C) above, wherein the detected miRNAs are five or more microRNAs selected from the group consisting of: (5E) A method according to any one of (5), (5A), (5B), and (5C) above, wherein the detected miRNAs are 10 or more microRNAs selected from the group consisting of: (5F) A method according to any one of (5), (5A), (5B), and (5C) above, wherein the detected miRNAs are 15 or more microRNAs selected from the group consisting of: (5G) A method according to any one of (5), (5A), (5B), and (5C) above, wherein the detected miRNAs are 20 or more microRNAs selected from the group consisting of: (5H) A method according to any one of (5D) to (5G) above, wherein the prediction accuracy and specificity exceed 50%. (5I) A method according to any one of (5D) to (5G) above, wherein the prediction accuracy and specificity exceed 60%. (5J) A method according to any one of (5D) to (5G) above, wherein the prediction accuracy and specificity exceed 70%. (5K) A method according to any one of (5D) to (5G) above, wherein the prediction accuracy and specificity exceed 80%. (6) A method for predicting the possibility that a subject has lung cancer, comprising detecting one or more microRNAs selected from the group consisting of hsa-miR-147b, hsa-miR-3912-5p, hsa-miR-148a-5p, hsa-miR-6773-5p, hsa-miR-3681-5p, hsa-miR-3976, hsa-miR-3121-5p, hsa-miR-6082, and hsa-miR-10 in the urine of the subject, and predicting the possibility that the subject has cancer using the expression level of the microRNA as an indicator. 6b-5p, hsa-miR-758-3p, hsa-miR-4418, hsa-miR-216a-5p, hsa-miR-34a-3p, hsa-miR-516b-5p, hsa-miR-140-5p, hsa-miR-7154-5p, hsa-miR-616- 5p, hsa-miR-5701, hsa-miR-582-3p, hsa-miR-626, hsa-miR-3653-3p, hsa-miR-4320, hsa-miR-3689a-5p, hsa-miR-3689b-5p, hsa-miR-3689e, hsa-m iR-8058, hsa-miR-107, hsa-miR-10a-5p, hsa-miR-624-3p, hsa-miR-4683, hsa-miR-30a-5p, hsa-miR-222-3p, hsa-miR-580-5p, hsa-miR-5581-5p, hsa-miR-200c-3p, hsa-miR-2052, hsa-miR-5089-5p, hsa-miR-17-5p, hsa-miR-452-3p, hsa-miR-329-3p, hsa-miR-5092, hsa-miR-585-3p, hsa-miR- 4503, hsa-miR-5011-5p, hsa-miR-372-5p, hsa-miR-5589-3p, hsa-miR-2114-5p, hsa-miR-4799-5p, hsa-miR-4422, hsa-miR-520d-3p, hsa-miR-686 4-5p, hsa-miR-182-5p, hsa-miR-363-3p, hsa-miR-215-3p, hsa-miR-2681-3p, hsa-miR-922, hsa-miR-450a-2-3p, hsa-miR-520f-3p, hsa-miR-4501,hsa-miR-660-5p、hsa-miR-1911-5p、hsa-miR-20a-3p、hsa-miR-362-5p、hsa-miR-380-5p、hsa-miR-597-3p、hsa-miR-448、hsa-miR-3182、hsa-miR-99a-3p、hsa-miR-616-3p、hsa-miR-22-5p、hsa-miR-3591-5p、hsa-miR-4293、hsa-miR-433-3p、hsa-miR-1183、hsa-miR-662、hsa-miR-195-5p、hsa-miR-96-5p、hsa-miR-630、hsa-miR-7a-3p、hsa-miR-30e-3p、hsa-miR-361-5p、hsa-miR-6715b-3p、hsa-miR-563、hsa-miR-1263、hsa-miR-16-5p、hsa-miR-425-5p、hsa-miR-519a-3p、hsa-miR-655-5p、hsa-miR-429、hsa-miR-576-5p、hsa-miR-517-5p、hsa-miR-659-5p、hsa-miR-375、hsa-miR-4719、hsa-miR-891a-3p、hsa-miR-653-5p、hsa-miR-598-3p、hsa-miR-181a-5p、hsa-miR-15b-3p、hsa-miR-431-5p、hsa-miR-143-5p、hsa-miR-3157-5p、hsa-miR-181d-5p、hsa-miR-3978、hsa-miR-539-5p、hsa-let-7e-5p、hsa-miR-938、hsa-miR-369-5p、hsa-miR-656-3p、hsa-miR-132-3p、hsa-miR-23a-3p、hsa-miR-4699-3p、hsa-miR-624-5p、hsa-miR-7843-3p、hsa-miR-4524a-3p、hsa-miR-611、hsa-miR-5002-5p、hsa-miR-1286、hsa-miR-3144-3p、hsa-miR-4650-3p、hsa-miR-7162-5p、hsa-miR-548ba、hsa-miR-221-3p、hsa-miR-628-3p、hsa-miR-6715a-3p、hsa-miR-1297、hsa-miR-3907、hsa-miR-23b-5p、hsa-miR-374b-5p、hsa-miR-371a-3p、hsa-miR-372-3p 、hsa-miR-7158-3p、hsa-miR-10b-5p、hsa-miR-554、hsa-miR-4325、hsa-m iR-196a-5p, hsa-miR-5702, hsa-miR-519b-3p, hsa-miR-542-5p, hsa-miR-1298-5p, hsa-miR-20b-5p, hsa-miR-4661-5p, hsa-miR-172, hsa-miR-70 8-5p、hsa-miR-509-5p、hsa-miR-450a-5p、hsa-miR-7153-5p、hsa-miR-135a-5p、hsa-miR-4752、hsa-miR-578、hsa-miR-492、hsa-miR-93-3p、hsa- miR-1180-5p, hsa-miR-500a-5p, hsa-miR-181d-3p, hsa-miR-516b-3p, hsa-miR-516a-3p, hsa-miR-489-3p, hsa-miR-21-3p, hsa-miR-96-3p, hsa-m iR-383-3p, hsa-miR-3921, hsa-miR-4762-5p, hsa-miR-1912, hsa-miR-3613-3p, hsa-miR-203b-5p, hsa-miR-135b-5p, hsa-miR-591, hsa-miR-521 hsa-miR-631, hsa-miR-4677-5p, hsa-miR-4804-5p, hsa-miR-5571-3p, hsa-miR-122-3p, hsa-miR-30c-5p, hsa-miR-6837-3p, hsa-miR-145-5p, hs a-miR-4643, hsa-miR-4522, hsa-miR-5588-5p, hsa-miR-888-5p, hsa-miR-4781-5p, hsa-miR-520a-3p, hsa-miR-28-5p, hsa-miR-580-3p, hsa-miR- 4774-3p、hsa-miR-512-3p、hsa-miR-605-3p、hsa-miR-511-5p、hsa-miR-6768-3p、hsa-miR-552-5p、hsa-miR-491-3p、hsa-miR-173a、hsa-miR-635、hsa-let-7g-3p、hsa-miR-378a-5p、hsa-miR-200b-3p、hsa-miR-337-5p、h sa-miR-4694-3p、hsa-miR-3163、hsa-let-7f-2-3p、hsa-miR-4659a-3p、h sa-miR-5696、hsa-miR-103a-3p、hsa-miR-376c-3p、hsa-miR-4650-5p、hsa-miR-892c-3p、hsa-miR-203a-3p、hsa-miR-8055、hsa-miR-5004-3p、hsa- miR-339-5p, hsa-miR-7156-5p, hsa-miR-345-5p, hsa-miR-526b-3p, hsa-miR-16-2-3p, hsa-miR-552-3p, hsa-miR-340-3p, hsa-miR-3193, hsa-miR- 517a-3p、hsa-miR-517b-3p、hsa-miR-1257、hsa-miR-3529-5p、hsa-miR-2 9a-3p、hsa-miR-566、hsa-miR-1205、hsa-miR-3622b-3p、hsa-miR-1-5p、hs a-miR-5187-3p, hsa-miR-130a-5p, hsa-miR-15a-3p, hsa-miR-146a-5p, hsa-miR-337-3p, hsa-miR-4691-3p, hsa-miR-205-5p, hsa-miR-374c-5p, h sa-miR-374c-3p, hsa-miR-551b-3p, hsa-miR-4694-5p, hsa-miR-276-5p, hsa-miR-520g-3p, hsa-miR-519e-3p, hsa-miR-299-5p, hsa-miR-25-3p, hs a-miR-8079, hsa-miR-6510-3p, hsa-miR-223-5p, hsa-miR-216b-3p, hsa-miR-99b-5p, hsa-miR-1289, hsa-miR-8086, hsa-miR-195-3p, hsa-miR-785 3-5p、hsa-miR-4794、hsa-miR-1911-3p、hsa-miR-6811-3p、hsa-miR-605-5p、hsa-miR-4704-5p、hsa-miR-204-5p、hsa-miR-302d-5p、hsa-miR-4266、hsa-miR-519d-3p, hsa-miR-5684, hsa-miR-4755-5p, hsa-miR-589-5p, hsa-miR-125b-5p, hsa-miR-1291, hsa-miR-1200, hsa-miR-4724-3p, hsa-miR-93-5p, hsa-miR-942-5p, hsa-miR-432-3p, hsa-miR-7-2-3p, hsa-miR-642a-5p, hsa-miR-370-5p, hsa-miR-8074 hsa-miR-512-5p, hsa-miR-506-3p, hsa-miR-6774-3p, hsa-miR-1269b, hsa-miR-150-5p, hsa-miR-3155a, hsa-miR-208a-5p, hsa-miR-501-5p, hsa-miR-30c-1-3p, hsa-miR-5571-5p, hsa-miR-6758-3p, hsa-miR-1184, hsa-miR-454-5p, hsa-miR-34b-5p, hsa-miR-68 38-5p, hsa-miR-92b-3p, hsa-miR-4652-3p, hsa-miR-4747-3p, hsa-miR-1255b-2-3p, hsa-miR-1282, hsa-miR-173h-3p, hsa-miR-7703, hsa-miR-3919, hsa-miR-324-5p, hsa-miR-1251-3p, hsa-miR-671-5p, hsa-miR-6508-5p, hsa-miR-23b-3p, hsa-miR-3184-5p, hs a-miR-6744-3p, hsa-miR-642a-3p, hsa-miR-98-3p, hsa-miR-4288, hsa-miR-1203, hsa-miR-3181, hsa-miR-6500-5p, hsa-miR-380-3p, hsa-miR-574-5p, hsa-miR-4328, hsa-miR-5584-3p, hsa-miR-6781-3p, hsa-miR-632, hsa-miR-193b-3p, hsa-miR-6841-3p. (6A) The method according to (6) above, wherein the detected miRNA is one or more microRNAs selected from the group consisting of hsa-miR-147b, hsa-miR-3912-5p, hsa-miR-148a-5p, hsa-miR-6773-5p, hsa-miR-3681-5p, hsa-miR-3976, hsa-miR-3121-5p, hsa-miR-6082, hsa-miR-106b-5p, hsa-miR-758-3p, hsa-miR-4418, hsa-miR-216a-5p, and hsa-miR- 34a-3p, hsa-miR-516b-5p, hsa-miR-140-5p, hsa-miR-7154-5p, hsa-miR-616-5p, hsa-miR-5701, hsa-miR-582-3p, hsa-miR-626, hsa-miR-3653-3p, hsa-miR-4320, hsa-miR-3689a-5p, hsa-miR-3689b-5p, hsa-miR-3689e, hsa-miR-8058, hsa-miR-107, hsa-miR-10a-5p, hsa-miR-624-3p, hsa-miR-4 683, hsa-miR-30a-5p, hsa-miR-222-3p, hsa-miR-580-5p, hsa-miR-5581-5p, hsa-miR-200c-3p, hsa-miR-2052, hsa-miR-5089-5p, hsa-miR-17-5p, h sa-miR-452-3p, hsa-miR-329-3p, hsa-miR-5092, hsa-miR-585-3p, hsa-miR-4503, hsa-miR-5011-5p, hsa-miR-372-5p, hsa-miR-5589-3p, hsa-miR- 2114-5p, hsa-miR-4799-5p, hsa-miR-4422, hsa-miR-520d-3p, hsa-miR-6864-5p, hsa-miR-182-5p, hsa-miR-363-3p, hsa-miR-215-3p, hsa-miR-268 1-3p, hsa-miR-922, hsa-miR-450a-2-3p, hsa-miR-520f-3p, hsa-miR-4501, hsa-miR-660-5p, hsa-miR-1911-5p, hsa-miR-20a-3p, hsa-miR-362-5p,hsa-miR-380-5p、hsa-miR-597-3p、hsa-miR-448、hsa-miR-3182、hsa-miR-99a-3p、hsa-miR-616-3p、hsa-miR-22-5p、hsa-miR-3591-5p、hsa-miR-4293、hsa-miR-433-3p、hsa-miR-1183、hsa-miR-662、hsa-miR-195-5p、hsa-miR-96-5p、hsa-miR-630、hsa-miR-7a-3p、hsa-miR-30e-3p、hsa-miR-361-5p、hsa-miR-6715b-3p、hsa-miR-563、hsa-miR-1263、hsa-miR-16-5p、hsa-miR-425-5p、hsa-miR-519a-3p、hsa-miR-655-5p、hsa-miR-429、hsa-miR-576-5p、hsa-miR-517-5p、hsa-miR-659-5p、hsa-miR-375、hsa-miR-4719、hsa-miR-891a-3p、hsa-miR-653-5p、hsa-miR-598-3p、hsa-miR-181a-5p、hsa-miR-15b-3p、hsa-miR-431-5p、hsa-miR-143-5p、hsa-miR-3157-5p、hsa-miR-181d-5p、hsa-miR-3978、hsa-miR-539-5p、hsa-let-7e-5p、hsa-miR-938、hsa-miR-369-5p、hsa-miR-656-3p、hsa-miR-132-3p、hsa-miR-23a-3p、hsa-miR-4699-3p、hsa-miR-624-5p、hsa-miR-7843-3p、hsa-miR-4524a-3p、hsa-miR-611、hsa-miR-5002-5p、hsa-miR-1286、hsa-miR-3144-3p、hsa-miR-4650-3p、hsa-miR-7162-5p、hsa-miR-548ba、hsa-miR-221-3p、hsa-miR-628-3p、hsa-miR-6715a-3p、hsa-miR-1297、hsa-miR-3907、hsa-miR-23b-5p、hsa-miR-374b-5p、hsa-miR-371a-3p、hsa-miR-372-3p、hsa-miR-7158-3p, hsa-miR-10b-5p, hsa-miR-554, hsa-miR-4325, hsa-miR-196a-5p, hsa-miR-5702, hsa-miR-519b-3p, hsa-miR-542-5p, hsa-miR-1298-5p, hsa-miR-20b-5p, hsa-miR-4661-5p hsa-miR-172, hsa-miR-708-5p, hsa-miR-509-5p, hsa-miR-450a-5p, hsa-miR-7153-5p, hsa-miR-135a-5p, hsa-miR-4752, hsa-miR-578, hsa-miR-492, hsa-miR-93-3p, hsa-miR-1180-5p, hsa-m iR-500a-5p、hsa-miR-181d-3p、hsa-miR-516b-3p、hsa-miR-516a-3p、hsa-miR-489-3p、hsa-miR-21-3p、hsa-miR-96-3p、hsa-miR-383-3p、hsa-miR-3921、hsa-miR-4762-5p、hsa-miR-1912、hsa -miR-3613-3p、hsa-miR-203b-5p、hsa-miR-135b-5p、hsa-miR-591、hsa-miR-521、hsa-miR-631、hsa-miR-4677-5p、hsa-miR-4804-5p、hsa-miR-5571-3p、hsa-miR-122-3p、hsa-miR-30c-5p。、 (6B) The method according to (6) above, wherein the detected miRNA is one or more microRNAs selected from the group consisting of hsa-miR-147b, hsa-miR-3912-5p, hsa-miR-148a-5p, hsa-miR-6773-5p, hsa-miR-3681-5p, hsa-miR-3976, hsa-miR-3121-5p, hsa-miR-6082, hsa-miR-106b-5p, hsa-miR-758-3p, hsa-miR-4418, hsa-miR-216a-5p, and hsa-miR- 34a-3p, hsa-miR-516b-5p, hsa-miR-140-5p, hsa-miR-7154-5p, hsa-miR-616-5p, hsa-miR-5701, hsa-miR-582-3p, hsa-miR-626, hsa-miR-3653-3p, hsa-miR-4320, hsa-miR-3689a-5p, hsa-miR-3689b-5p, hsa-miR-3689e, hsa-miR-8058, hsa-miR-107, hsa-miR-10a-5p, hsa-miR-624-3p, hsa-miR-4 683, hsa-miR-30a-5p, hsa-miR-222-3p, hsa-miR-580-5p, hsa-miR-5581-5p, hsa-miR-200c-3p, hsa-miR-2052, hsa-miR-5089-5p, hsa-miR-17-5p, h sa-miR-452-3p, hsa-miR-329-3p, hsa-miR-5092, hsa-miR-585-3p, hsa-miR-4503, hsa-miR-5011-5p, hsa-miR-372-5p, hsa-miR-5589-3p, hsa-miR- 2114-5p, hsa-miR-4799-5p, hsa-miR-4422, hsa-miR-520d-3p, hsa-miR-6864-5p, hsa-miR-182-5p, hsa-miR-363-3p, hsa-miR-215-3p, hsa-miR-268 1-3p, hsa-miR-922, hsa-miR-450a-2-3p, hsa-miR-520f-3p, hsa-miR-4501, hsa-miR-660-5p, hsa-miR-1911-5p, hsa-miR-20a-3p, hsa-miR-362-5p,hsa-miR-380-5p, hsa-miR-597-3p, hsa-miR-448, hsa-miR-3182, hsa-miR-99a-3p, hsa-miR-616-3p, hsa-miR-22-5p, hsa-miR-3591-5p, hsa-miR-4293, hsa-miR-433-3p, hsa-miR-1183 hsa-miR-662, hsa-miR-195-5p, hsa-miR-96-5p, hsa-miR-630, hsa-miR-7a-3p, hsa-miR-30e-3p, hsa-miR-361-5p, hsa-miR-6715b-3p, hsa-miR-563, hsa-miR-1263, hsa-miR-16-5p, hs a-miR-425-5p, hsa-miR-519a-3p, hsa-miR-655-5p, hsa-miR-429, hsa-miR-576-5p, hsa-miR-517-5p, hsa-miR-659-5p, hsa-miR-375, hsa-miR-4719, hsa-miR-891a-3p, hsa-miR-653-5 p、hsa-miR-598-3p、hsa-miR-181a-5p、hsa-miR-15b-3p、hsa-miR-431-5p、hsa-miR-143-5p、hsa-miR-3157-5p、hsa-miR-181d-5p、hsa-miR-3978、hsa-miR-539-5p、およびhsa-let-7e-5p。、 (6C) The method according to (6) above, wherein the detected miRNA is one or more microRNAs selected from the group consisting of hsa-miR-147b, hsa-miR-3912-5p, hsa-miR-148a-5p, hsa-miR-6773-5p, hsa-miR-3681-5p, hsa-miR-3976, and hsa-miR -3121-5p, hsa-miR-6082, hsa-miR-106b-5p, hsa-miR-758-3p, hsa-miR-4418, hsa-miR-216a-5 p, hsa-miR-34a-3p, hsa-miR-516b-5p, hsa-miR-140-5p, hsa-miR-7154-5p, hsa-miR-616-5p, hs a-miR-5701, hsa-miR-582-3p, hsa-miR-626, hsa-miR-3653-3p, hsa-miR-4320, hsa-miR-3689a -5p, hsa-miR-3689b-5p, hsa-miR-3689e, hsa-miR-8058, hsa-miR-107, hsa-miR-10a-5p, hsa-m iR-624-3p, hsa-miR-4683, hsa-miR-30a-5p, hsa-miR-222-3p, hsa-miR-580-5p, hsa-miR-5581 -5p, hsa-miR-200c-3p, hsa-miR-2052, hsa-miR-5089-5p, hsa-miR-17-5p, and hsa-miR-452-3p. (6D) A method according to any one of (6), (6A), (6B), and (6C) above, wherein the detected miRNAs are five or more microRNAs selected from the group consisting of: (6E) A method according to any one of (6), (6A), (6B), and (6C) above, wherein the detected miRNAs are 10 or more microRNAs selected from the group consisting of: (6F) A method according to any one of (6), (6A), (6B), and (6C) above, wherein the detected miRNAs are 15 or more microRNAs selected from the group consisting of: (6G) A method according to any one of (6), (6A), (6B), and (6C) above, wherein the detected miRNAs are 20 or more microRNAs selected from the group consisting of: (6H) A method according to any one of (6D) to (6G) above, in which any one or all of the prediction accuracy, sensitivity, and specificity exceeds 50%. (6I) A method according to any one of (6D) to (6G) above, wherein any one or all of the prediction accuracy, sensitivity, and specificity exceeds 60%. (6J) A method according to any one of (6D) to (6G) above, wherein any one or all of the prediction accuracy, sensitivity, and specificity exceeds 70%. (6K) A method according to any one of (6D) to (6G) above, wherein any one or all of the predictive accuracy, sensitivity, and specificity exceeds 80%. (6L) A method according to any one of (6D) to (6K) above, wherein the area under the curve (AUC) of the receiver operating characteristic curve (ROC) is greater than 0.5, greater than 0.6, greater than 0.7, greater than 0.8, greater than 0.9, or greater than 0.95. (6M) The method according to (6L) above, which predicts whether a subject has a possibility of having lung cancer based on a cutoff value where the true positive rate is greater than the false positive rate. (7) A method for predicting the possibility that a subject has lung cancer, comprising detecting in the urine of the subject at least one, two, three, four, five, six, seven, eight, nine, ten or more, fifteen or more, or twenty or more, or all, of the following microRNAs: hsa-let-7a-3p, hsa-let-7g-5p, hsa-miR-100-3p, hsa-miR-101-3p, hsa-miR-105-3p, hsa-miR-10b-3p, hsa-miR-1185-5p, and hsa-miR-119. 7, hsa-miR-1206, hsa-miR-1243, hsa-miR-1245b-3p, hsa-miR-1246, hsa-miR-1252-3p, hsa-miR-1252-5p, hsa-miR-1258, hsa-miR-126-3p, hsa-m iR-126-5p, hsa-miR-1277-3p, hsa-miR-1277-5p, hsa-miR-1279, hsa-miR-1295b-5p, hsa-miR-136-5p, hsa-miR-1-3p, hsa-miR-145-3p, hsa-miR-1 468-3p, hsa-miR-152-3p, hsa-miR-153-3p, hsa-miR-155-5p, hsa-miR-186-5p, hsa-miR-18a-5p, hsa-miR-190a-5p, hsa-miR-190b, hsa-miR-19a- 5p, hsa-miR-19b-1-5p, hsa-miR-19b-2-5p, hsa-miR-19b-3p, hsa-miR-2053, hsa-miR-205-3p, hsa-miR-2054, hsa-miR-208a-3p, hsa-miR-20a-5p, hsa-miR-219a-1-3p, hsa-miR-219b-3p, hsa-miR-301a-3p, hsa-miR-30d-3p, hsa-miR-30e-5p, hsa-miR-3118, hsa-miR-3123, hsa-miR-3129-5p, hs a-miR-3135a, hsa-miR-3140-3p, hsa-miR-3143, hsa-miR-3152-3p, hsa-miR-3167, hsa-miR-3169, hsa-miR-3183, hsa-miR-3201, hsa-miR-335-5p,hsa-miR-339-3p, hsa-miR-3607-5p, hsa-miR-3616-5p, hsa-miR-3617-5p, hsa-miR-3618, hsa-miR-3662, hsa-miR-3668, hsa-miR-3683, hsa-miR-3 686, hsa-miR-3688-3p, hsa-miR-369-3p, hsa-miR-374a-3p, hsa-miR-374a-5p, hsa-miR-376a-5p, hsa-miR-3927-3p, hsa-miR-3942-5p, hsa-miR-4 277, hsa-miR-4302, hsa-miR-4432, hsa-miR-4452, hsa-miR-4457, hsa-miR-4474-5p, hsa-miR-4477b, hsa-miR-4480, hsa-miR-4495, hsa-miR-4504 hsa-miR-4509, hsa-miR-450a-1-3p, hsa-miR-450b-3p, hsa-miR-455-5p, hsa-miR-4633-3p, hsa-miR-4639-5p, hsa-miR-4668-3p, hsa-miR-4671- 3p, hsa-miR-4679, hsa-miR-4693-3p, hsa-miR-4699-5p, hsa-miR-4704-3p, hsa-miR-4714-3p, hsa-miR-4720-3p, hsa-miR-4735-5p, hsa-miR-4757 -3p、hsa-miR-4760-5p、hsa-miR-4772-5p、hsa-miR-4777-5p、hsa-miR-4781-3p、hsa-miR-4782-3p、hsa-miR-4782-5p、hsa-miR-4790-3p、hsa-miR- 4791、hsa-miR-4795-5p、hsa-miR-4796-3p、hsa-miR-4798-5p、hsa-miR-4799-3p、hsa-miR-4802-5p、hsa-miR-499a-5p、hsa-miR-5009-3p、hsa-miR -5009-5p、hsa-miR-506-5p、hsa-miR-507、hsa-miR-510-3p、hsa-miR-513b-3p、hsa-miR-514a-5p、hsa-miR-5191、hsa-miR-544a、hsa-miR-545-5p、hsa-miR-548a-3p, hsa-miR-548a-5p, hsa-miR-548aa, hsa-miR-548t-3p, hsa-miR-548ac, hsa-miR-548ad-5p, hsa-miR-548ae-5p, hsa-miR-548ae-3p, hsa-miR-548ag, hsa-miR-548ah-5p, hsa-miR-548ak, hsa-miR-548al, hsa-miR-548am-3p, hsa-miR-548ao-5p, hsa-miR-548ap-5p, hsa-miR-548 aq-5p、hsa-miR-548at-3p、hsa-miR-548au-5p、hsa-miR-548az-5p、hsa-m iR-548b-5p、hsa-miR-548c-5p、hsa-miR-548o-5p、hsa-miR-548am-5p、hs a-miR-548g-5p、hsa-miR-548x-5p、hsa-miR-548aj-5p、hsa-miR-548j-5p 、hsa-miR-548k、hsa-miR-548m、hsa-miR-548p、hsa-miR-548t-5p、hsa-mi R-548u、hsa-miR-548v、hsa-miR-548x-3p、hsa-miR-549a、hsa-miR-553、h sa-miR-556-3p、hsa-miR-5579-5p、hsa-miR-5583-5p、hsa-miR-559、hsa- miR-5590-3p, hsa-miR-5590-5p, hsa-miR-5591-5p, hsa-miR-561-5p, hsa-miR-568, hsa-miR-5687, hsa-miR-569, hsa-miR-5692c, hsa-miR-5697 sa-miR-5700, hsa-miR-570-3p, hsa-miR-577, hsa-miR-582-5p, hsa-miR-587, hsa-miR-590-3p, hsa-miR-6079, hsa-miR-6128, hsa-miR-618, hsa-m iR-621, hsa-miR-628-5p, hsa-miR-633, hsa-miR-648, hsa-miR-6508-3p, hsa-miR-651-3p, hsa-miR-652-3p, hsa-miR-6733-5p, hsa-miR-6811-5phsa-miR-6844, hsa-miR-6854-5p, hsa-miR-7161-3p, hsa-miR-759, hsa-miR-7-5p, hsa-miR-7852-3p, hsa-miR-873-5p, hsa-miR-876-5p, hsa-miR- 9-3p、hsa-miR-95-3p、hsa-miR-95-5p、hsa-miR-9-5p、hsa-miR-4525、hsa-miR-6760-5p、hsa-miR-4538、hsa-miR-5698、hsa-miR-5189-5p、hsa-miR- 671-5p、hsa-miR-936、hsa-miR-4307、hsa-miR-6815-5p、hsa-miR-6076、hsa-miR-708-5p、hsa-miR-3187-5p、hsa-miR-3144-3p、hsa-miR-4691-5p、 hsa-miR-4700-5p, hsa-miR-576-5p, hsa-miR-3652, hsa-miR-598-3p, hsa-miR-7151-3p, hsa-miR-7162-5p, hsa-miR-1229-5p, hsa-miR-6746-5p, hs a-miR-4762-5p、hsa-miR-1307-3p、hsa-miR-1273g-3p、hsa-miR-4428、hsa-miR-6515-5p、hsa-miR-1273g-5p、hsa-miR-433-3p、hsa-miR-452-3p、h sa-miR-3917, hsa-miR-1224-5p, hsa-miR-6892-5p, hsa-miR-520d-5p, hsa-miR-5092, hsa-miR-30c-1-3p, hsa-miR-1293, hsa-miR-7851-3p, hsa-mi R-3934-5p, hsa-miR-3122, hsa-miR-3177-3p, hsa-miR-4800-5p, hsa-miR-4436b-3p, hsa-miR-3928-3p, hsa-miR-630, hsa-miR-628-3p, hsa-miR-67 96-5p、hsa-miR-3605-5p、hsa-miR-30e-3p、hsa-miR-6801-5p、hsa-miR-6131、hsa-miR-448、hsa-miR-6834-5p、hsa-miR-3156-5p、hsa-miR-517-5p、hsa-miR-4520-5p、hsa-miR-2276-3p、hsa-miR-3591-3p、hsa-miR-4727-3p、hsa-miR-4499、hsa-miR-1471、hsa-miR-1273h-5p、hsa-miR-4539、hsa-miR-3655、hsa-miR-4690-5p、hsa-miR-6871-5p、hsa-miR-4496、hsa-miR-6772-5p、hsa-miR-4686、hsa-miR-1297、hsa-miR-450a-2-3p、hsa-miR-6745、hsa-miR-3153、hsa-miR-27a-3p、hsa-miR-106b-5p、hsa-miR-519c-5p、hsa-miR-523-5p、hsa-miR-518e-5p、hsa-miR-522-5p、hsa-miR-519a-5p、hsa-miR-519b-5p、hsa-miR-4676-5p、hsa-miR-650、hsa-miR-3922-5p、hsa-miR-4489、hsa-miR-4638-5p、hsa-miR-185-3p、hsa-miR-2467-3p、hsa-miR-4453、hsa-let-7e-5p、hsa-miR-296-3p、hsa-miR-8074、hsa-miR-6876-5p、hsa-miR-6086、hsa-miR-4474-3p、hsa-miR-4776-3p、hsa-miR-1250-5p、hsa-miR-4260、hsa-miR-6747-5p、hsa-miR-181d-3p、hsa-miR-4535、hsa-miR-3177-5p、hsa-miR-4533、hsa-miR-4635、hsa-miR-4776-5p、hsa-miR-4257、hsa-miR-3160-3p、hsa-miR-5702、hsa-miR-4306、hsa-miR-4483、hsa-miR-4472、hsa-miR-3064-3p、hsa-miR-4710、hsa-miR-4293、hsa-miR-449c-5p、hsa-miR-5589-5p、hsa-miR-4443、hsa-miR-4448、hsa-miR-3935、hsa-miR-16-5p、hsa-miR-181a-5p、hsa-miR-147b、hsa-miR-4767、hsa-miR-4677-5p、hsa-miR-6776-5p、hsa-miR-7109-5p、hsa-miR-4669、hsa-miR-4486、hsa-miR-1587、hsa-miR-363-3p、hsa-miR-5701、hsa-miR-921、hsa-miR-5581-5p、hsa-miR-4259、hsa-、 miR-203b-5p, hsa-miR-3653-3p, hsa-miR-4657, hsa-miR-5589-3p, hsa-miR-2681-3p, hsa-miR-6826-5p, hsa-miR-4647, hsa-miR-4540, hsa-miR- 361-5p、hsa-miR-4784、hsa-miR-6861-5p、hsa-miR-6812-5p、hsa-miR-608、hsa-miR-1912、hsa-miR-554、hsa-miR-519a-3p、hsa-miR-891a-3p、hs a-miR-6872-5p, hsa-miR-4781-5p, hsa-miR-4273, hsa-miR-4769-5p, hsa-miR-505-5p, hsa-miR-7158-3p, hsa-miR-527, hsa-miR-518a-5p, hsa-m iR-1273f, hsa-miR-624-5p, hsa-miR-125a-3p, hsa-miR-6830-5p, hsa-miR-520d-3p, hsa-miR-6757-5p, hsa-miR-4785, hsa-miR-6068, hsa-miR-12 72, hsa-miR-4654, hsa-miR-564, hsa-miR-563, hsa-miR-4300, hsa-miR-4665-5p, hsa-miR-892c-3p, hsa-miR-6778-5p, hsa-miR-4419b, hsa-miR- 329-3p、hsa-miR-212-5p、hsa-miR-616-3p、hsa-miR-4269、hsa-miR-4487、hsa-miR-1180-5p、hsa-miR-7850-5p、hsa-miR-492、hsa-miR-718、hsa-m iR-1972, hsa-miR-4296, hsa-miR-516b-3p, hsa-miR-516a-3p, hsa-miR-4320, hsa-miR-4529-5p, hsa-miR-656-3p, hsa-miR-6500-3p, hsa-miR-76 6-5p、hsa-miR-466、hsa-miR-6777-5p、hsa-miR-1909-5p、hsa-miR-187-3p、hsa-miR-8079、hsa-miR-30a-5p、hsa-miR-5002-3p、hsa-miR-6833-5p、hsa-miR-4756-3p, hsa-let-7f-2-3p, hsa-miR-5708, hsa-miR-4721, hsa-miR-8085, hsa-miR-3591-5p, hsa-miR-6859-5p, hsa-miR-5006-5p, hsa-mi R-4747-5p, hsa-miR-6827-5p, hsa-miR-3612, hsa-miR-4701-3p, hsa-miR-4418, hsa-miR-4449, hsa-miR-181d-5p, hsa-miR-3619-3p, hsa-miR-6817 -5p、hsa-miR-6759-5p、hsa-miR-3654、hsa-miR-3164、hsa-miR-491-3p、hsa-miR-3176、hsa-miR-4683、hsa-miR-6807-5p、hsa-miR-5588-5p、hsa-mi R-302c-5p、hsa-miR-4522、hsa-miR-1199-5p、hsa-miR-372-3p、hsa-miR-891a-5p、hsa-miR-1306-3p、hsa-miR-6894-5p、hsa-miR-3613-3p、hsa-miR -548ba、hsa-miR-6795-5p、hsa-miR-6794-5p、hsa-miR-585-3p、hsa-miR-194-3p、hsa-miR-5010-5p、hsa-miR-2052、hsa-miR-614、hsa-miR-6751-5p hsa-miR-5089-3p, hsa-miR-1289, hsa-miR-668-5p, hsa-miR-3622b-5p, hsa-miR-6887-5p, hsa-miR-4524a-3p, hsa-miR-3689a-3p, hsa-miR-4650- 5p、hsa-miR-3689b-3p、hsa-miR-3689c、hsa-miR-624-3p、hsa-miR-6129、 hsa-miR-216a-5p、hsa-miR-520b、hsa-miR-4755-5p、hsa-miR-323a-5p、hs a-miR-6726-5p、hsa-miR-516b-5p、hsa-miR-7106-5p、hsa-miR-653-5p、hsa-miR-494-5p、hsa-miR-6780b-5p、hsa-miR-1910-3p、hsa-miR-3160-5p、hsa-miR-5093, hsa-miR-99a-3p, hsa-miR-8071, hsa-miR-4659a-3p, hsa-miR-597-3p, hsa-miR-4458, hsa-miR-6847-5p, hsa-miR-4436a, hsa-miR- 17-5p, hsa-miR-185-5p, hsa-miR-4681, hsa-miR-8077, hsa-miR-4440, hsa-let-7g-3p, hsa-miR-375, hsa-miR-10a-5p, hsa-miR-520e, hsa-miR-607 2, hsa-miR-3145-5p, hsa-miR-6723-5p, hsa-miR-4692, hsa-miR-4796-5p, hsa-miR-6849-5p, hsa-miR-4430, hsa-miR-6499-5p, hsa-miR-3151-5p, h sa-miR-182-5p, hsa-miR-195-5p, hsa-miR-3681-5p, hsa-miR-6864-5p, hsa-miR-4711-3p, hsa-miR-380-3p, hsa-miR-374c-5p, hsa-miR-758-5p, hs a-miR-6842-5p, hsa-miR-8080, hsa-miR-520f-3p, hsa-miR-4646-5p, hsa-miR-103a-3p, hsa-miR-3189-3p, hsa-miR-4691-3p, hsa-miR-877-5p, hsa -miR-6769b-5p、hsa-miR-5580-5p、hsa-miR-1911-5p、hsa-miR-519b-3p、hsa-miR-660-5p、hsa-miR-4644、hsa-miR-6133、hsa-miR-138-1-3p、hsa-m iR-193a-5p、hsa-miR-222-3p、hsa-miR-603、hsa-miR-23b-3p、hsa-miR-5089-5p、hsa-miR-6799-5p、hsa-miR-6715a-3p、hsa-miR-6869-3p、hsa-miR -4445-3p、hsa-miR-542-5p、hsa-miR-1286、hsa-miR-96-3p、hsa-miR-4743-5p、hsa-miR-4724-3p、hsa-miR-4262、hsa-miR-4507、hsa-miR-7160-5p、hsa-miR-605-3p, hsa-miR-200c-3p, hsa-miR-582-3p, hsa-miR-6868-5p, hsa-miR-6773-5p, hsa-miR-1185-1-3p, hsa-miR-3182, hsa-miR-6082, hs a-miR-150-3p、hsa-miR-5002-5p、hsa-miR-487a-5p、hsa-miR-8058、hsa-miR-4529-3p、hsa-miR-3713、hsa-miR-8075、hsa-miR-6877-5p、hsa-miR- 4325, hsa-miR-3130-5p, hsa-miR-616-5p, hsa-miR-1322, hsa-miR-6793-5p, hsa-miR-4694-5p, hsa-miR-29a-3p, hsa-miR-6127, hsa-miR-758-3p hsa-miR-2114-5p, hsa-miR-515-5p, hsa-miR-196a-5p, hsa-miR-4639-3p, hsa-miR-4799-5p, hsa-miR-4498, hsa-miR-6766-5p, hsa-miR-1255b-2-3 p、hsa-miR-380-5p、hsa-miR-4419a、hsa-miR-3622a-5p、hsa-let-7b-5p、hsa-miR-4650-3p、hsa-miR-29b-1-5p、hsa-miR-3137、hsa-miR-4447、hsa -miR-6500-5p、hsa-miR-3663-5p、hsa-miR-4451、hsa-miR-4422、hsa-miR-662、hsa-miR-122-3p、hsa-miR-6828-5p、hsa-miR-6884-5p、hsa-miR-45 02、hsa-miR-374b-5p、hsa-miR-4462、hsa-miR-4478、hsa-miR-431-3p、hsa-miR-23b-5p、hsa-miR-7975、hsa-miR-5011-5p、hsa-miR-3691-5p、hsa- miR-6768-3p, hsa-miR-591, hsa-miR-8086, hsa-miR-372-5p, hsa-miR-5189-3p, hsa-miR-107, hsa-miR-6891-5p, hsa-miR-3138, hsa-miR-6503-3phsa-miR-297, hsa-miR-370-5p, hsa-miR-3944-3p, hsa-miR-425-5p, hsa-miR-3978, hsa-miR-148a-5p, hsa-miR-4684-5p, hsa-miR-34a-3p, hsa-miR -1263、hsa-miR-769-5p、hsa-miR-4437、hsa-miR-2277-3p、hsa-miR-659-5p、hsa-miR-661、hsa-miR-6788-5p、hsa-miR-15b-3p、hsa-miR-1205、hsa- miR-1468-5p, hsa-miR-34a-5p, hsa-miR-3120-5p, hsa-miR-1247-3p, hsa-miR-454-5p, hsa-miR-656-5p, hsa-miR-626, hsa-miR-4441, hsa-miR-678 0a-5p、hsa-miR-6769a-5p、hsa-miR-1298-5p、hsa-miR-3157-5p、hsa-miR-6814-5p、hsa-miR-500a-5p、hsa-miR-1321、hsa-miR-4481、hsa-miR-611、 hsa-miR-1273a, hsa-miR-337-5p, hsa-miR-203a-5p, hsa-miR-4479, hsa-miR-4719, hsa-miR-8083, hsa-miR-132-3p, hsa-miR-20b-5p, hsa-miR-425 2, hsa-miR-429, hsa-miR-378b, hsa-miR-134-5p, hsa-miR-6741-5p, hsa-miR-1193, hsa-miR-143-5p, hsa-miR-515-3p, hsa-miR-4774-3p, hsa-miR- 8064, hsa-miR-1183, hsa-miR-5684, hsa-miR-1226-5p, hsa-miR-539-5p, hsa-miR-580-5p, hsa-miR-622, hsa-miR-3907, hsa-miR-6504-5p, hsa-miR -4653-3p、hsa-miR-4706、hsa-miR-4515、hsa-miR-3919、hsa-miR-3187-3p、hsa-miR-1271-5p、hsa-miR-6767-5p、hsa-miR-4804-5p、hsa-miR-1257、hsa-miR-3126-5p, hsa-miR-6731-5p, hsa-miR-3149, hsa-miR-4717-3p, hsa-miR-509-5p, hsa-miR-215-3p, hsa-miR-1178-3p, hsa-miR-1282, hsa-miR-3174, hsa-miR- 197-5p, hsa-miR-376c-3p, hsa-miR-5696, hsa-miR-3121-5p, hsa-miR-8082, hsa-miR-6823-5p, hsa-miR-4704-5p, hsa-miR-3616-3p, hsa-miR-688 1-5p、hsa-miR-4661-5p、hsa-miR-22-5p、hsa-miR-6730-5p、hsa-let-7e- 3p、hsa-miR-1238-5p、hsa-miR-526b-5p、hsa-miR-3163、hsa-miR-4514、h sa-miR-4699-3p, hsa-miR-7154-5p, hsa-miR-4521, hsa-miR-96-5p, hsa-miR-4754, hsa-miR-450a-5p, hsa-miR-4459, hsa-miR-922, hsa-miR-7153-5p, hsa-miR-29b-2-5p, hsa-miR-6738-3p, hsa-miR-6790-5p, hsa-miR-4470, hsa-miR-4732-3p, hsa-miR-4709-3p, hsa-miR-5588-3p, hsa-miR-93 -3p、hsa-miR-6820-5p、hsa-miR-655-5p、hsa-miR-6514-3p、hsa-miR-1-5p、hsa-miR-10b-5p、hsa-miR-3193、hsa-miR-3976、hsa-miR-3678-3p、hsa -miR-3912-5p、hsa-miR-4708-3p、hsa-miR-5192、hsa-miR-140-5p、hsa-miR-4285、hsa-miR-3124-5p、hsa-miR-198、hsa-miR-3659、hsa-miR-3689a -5p、hsa-miR-3689b-5p、hsa-miR-3689e、hsa-miR-4643、hsa-miR-552-3p、hsa-miR-3186-3p、hsa-miR-424-3p、hsa-miR-578、hsa-miR-4304、hsa-m iR-504-3p, hsa-miR-595, hsa-miR-4501, hsa-miR-4746-3p, hsa-miR-362-5p, hsa-miR-4297, hsa-miR-6821-3p, hsa-miR-3074-5p, hsa-miR-4503hsa-miR-4518, hsa-miR-6715b-3p, hsa-miR-6736-5p, hsa-miR-7843-3p, hsa-miR-4420, hsa-miR-3927-5p, and hsa-miR-7157-5p. , (8) A urine extract obtained by contacting nanowires with urine from a patient with stage I cancer and extracting components bound to the nanowires. (8A) The urine extract according to (8) above, wherein the pH of the urine to be contacted with the nanowires is in a range of values ​​having a lower limit of 2, 3, 4, or 5 and an upper limit of 11, 10, 9, 8, 7, 6, or 5. (8B) A urine extract according to (8) or (8A) above, wherein the nanowires are metal oxide nanowires or nanowires whose surfaces are coated with metal oxide. (8C) The urine extract described in (8B) above, wherein the metal oxide is an oxide of a transition metal. (8D) A urine extract according to (8), (8A), (8B) or (8C) above, wherein the nanowires are zinc oxide nanowires or nanowires coated with zinc oxide. (8E) The urine extract of (8), (8A), (8B), (8C), or (8D) above, wherein the nanowires are contacted with urine under neutral pH conditions. (9) A urine extract according to (8), (8A), (8B), (8C), (8D) or (8E) above, containing the microRNA defined in (1) to (6) above. (10) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 20% or more of the extracellular vesicles contained in the urine. (10') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 25% or more of the extracellular vesicles contained in urine. (10A) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 30% or more of the extracellular vesicles contained in the urine. (10A') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 35% or more of the extracellular vesicles contained in the urine. (10B) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 40% or more of the extracellular vesicles contained in the urine. (10B') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 45% or more of the extracellular vesicles contained in the urine. (10C) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 50% or more of the extracellular vesicles contained in the urine. (10C') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 55% or more of the extracellular vesicles contained in the urine. (10D) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 60% or more of the extracellular vesicles contained in the urine. (10D') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing vesicles that account for 65% or more of the extracellular vesicles contained in the urine. (10E) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 70% or more of the extracellular vesicles contained in the urine. (10E') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 75% or more of the extracellular vesicles contained in the urine. (10F) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 80% or more of the extracellular vesicles contained in the urine. (10F') A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 85% or more of the extracellular vesicles contained in the urine. (10G) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 90% or more of the extracellular vesicles contained in urine. (10H) A ​​urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 95% or more of the extracellular vesicles contained in urine. (10I) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 97% or more of the extracellular vesicles contained in urine. (10J) A urine extract described in (9), (9A), (9B), (9C), (9D) or (9E) above, containing 99% or more of the extracellular vesicles contained in urine. (11) A urine extract according to any one of (1) to (4) above, which contains the concentrated microRNA. (11A) A urine extract according to any one of (1) to (4), (8), (8A), (8B), (8C), (8D) and (8E) above, which contains 500 or more types of microRNA present in urine. (12) Provided is a method for detecting microRNAs in a subject's body fluid, comprising detecting at least one microRNA or all microRNAs selected from the group consisting of hsa-miR-103a-2-5p, hsa-miR-106a-3p, hsa-miR-1185-2-3p, hsa-miR-1193, hsa-miR-1273g-3p, hsa-miR-1293, and hsa-miR-1301-5 by contacting a body fluid sample obtained from the subject with a detection agent for the microRNA to be detected. p,hsa-miR-152-5p,hsa-miR-184,hsa-miR-200c-5p,hsa-miR-2909,hsa-miR-298,hsa-miR-302b-3p,hsa-miR-3116,hsa-miR-3122,hsa-miR-3125, hsa-miR-3126-3p,hsa-miR-3129-3p,hsa-miR-3130-3p,hsa-miR-3133,hsa-miR-3137,hsa-miR-3150a-3p,hsa-miR-3174,hsa-miR-3177-5p,hsa-m iR-3179,hsa-miR-3186-3p,hsa-miR-3186-5p,hsa-miR-3187-3p,hsa-miR-3189-3p,hsa-miR-3190-3p,hsa-miR-3200-5p,hsa-miR-320a,hsa-miR -320c,hsa-miR-323b-5p,hsa-miR-325,hsa-miR-331-5p,hsa-miR-335-3p,hsa-miR-33a-3p,hsa-miR-342-3p,hsa-miR-34a-5p,hsa-miR-3606-3p, hsa-miR-3616-3p,hsa-miR-3621,hsa-miR-3622a-5p,hsa-miR-3659,hsa-miR-3690,hsa-miR-376b-3p,hsa-miR-3913-3p,hsa-miR-4269,hsa-miR- 4303,hsa-miR-4304,hsa-miR-4307,hsa-miR-4316,hsa-miR-4326,hsa-miR-4421,hsa-miR-4472,hsa-miR-4479,hsa-miR-4646-5p,hsa-miR-4660,hsa-miR-4688,hsa-miR-4695-3p,hsa-miR-4695-5p,hsa-miR-4721,hsa-miR-4724-5p,hsa-miR-4738-3p, hsa-miR-4740-3p,hsa-miR-4750-5p,hsa-miR-4753-5p,hsa-miR-4759,hsa-miR-4776-5p,hsa-miR-4778-3 p,hsa-miR-4796-5p,hsa-miR-487b-5p,hsa-miR-5008-3p,hsa-miR-514b-5p,hsa-miR-518f-3p,hsa-miR- 5194,hsa-miR-541-3p,hsa-miR-548c-3p,hsa-miR-548j-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-548h- 3p,hsa-miR-5572,hsa-miR-5580-5p,hsa-miR-5586-3p,hsa-miR-601,hsa-miR-6068,hsa-miR-6083,hsa- miR-6133,hsa-miR-617,hsa-miR-622,hsa-miR-625-5p,hsa-miR-649,hsa-miR-6504-5p,hsa-miR-6513-5p ,hsa-miR-651-5p,hsa-miR-6516-5p,hsa-miR-661,hsa-miR-664a-5p,hsa-miR-665,hsa-miR-6755-3p,hsa -miR-6767-5p, hsa-miR-6777-5p, hsa-miR-6782-5p, hsa-miR-8084, hsa-miR-888-3p, and hsa-miR-942-3p. ,

[0009] [1] A urine extract comprising the following (i) to (xvi): (i) any microRNA listed in Data S1 or Table 2 ; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Table 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4-15 a urine extract comprising microRNAs selected from the group consisting of: {which may independently comprise 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs from each table. That is, a urine extract may contain a combination of microRNAs from a particular table, or may contain multiple such combinations}. [2] Below (ii)~(xvi): (ii) any microRNA listed in Table 4-1 with a p-value less than 0.005; (iii) any microRNA listed in Table 4-2 with a p-value less than 0.005; (iv) any microRNA listed in Table 4-3 with a p-value less than 0.005; (v) any microRNA listed in Table 4-4 with a p-value less than 0.005; (vi) any microRNA listed in Table 4-5 with a p-value less than 0.005; (vii) any microRNA listed in Tables 4-6 with a p-value less than 0.005; (viii) any microRNA listed in Tables 4-7 with a p-value less than 0.005; (ix) any microRNA listed in Tables 4-8 with a p-value less than 0.005; (x) any microRNA listed in Tables 4-9 with a p-value less than 0.005; (xi) any microRNA listed in Tables 4-10 with a p-value less than 0.005; (xii) any microRNA listed in Tables 4-11 having a p-value of less than 0.005; and (xiii) any microRNA listed in Tables 4-12 with a p-value less than 0.005; (xiv) any microRNA listed in Tables 4-13 with a p-value less than 0.005; (xv) any microRNA listed in Tables 4-14 having a p-value of less than 0.005; and (xvi) any microRNA with a p-value of less than 0.005 listed in Tables 4-15 The urine extract according to [1] above, which contains microRNAs selected from the group consisting of: {which may independently contain one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more types of microRNAs in each table}. [3] The urine extract according to [1] above, (ii) any microRNA listed in Table 4-1 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} a urine extract comprising: [4] The urine extract according to [1] above, (iii) any microRNA listed in Table 4-2 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} a urine extract comprising: [5] The urine extract according to [1] above, (iv) any microRNA listed in Table 4-3 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} a urine extract comprising: [6] The urine extract according to [1] above, (v) any microRNA listed in Table 4-4 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} a urine extract comprising: [7] The urine extract according to [1] above, (vi) any microRNA listed in Table 4-5 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising: [8] The urine extract according to [1] above, (vii) any microRNA listed in Tables 4-6 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising: [9] The urine extract according to [1] above, (viii) any microRNA listed in Tables 4-7 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising:

[10] The urine extract according to [1] above, (ix) any microRNA listed in Tables 4-8 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} A urine extract comprising:

[11] The urine extract according to [1] above, (x) any microRNA listed in Tables 4-9 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} A urine extract comprising:

[12] The urine extract according to [1] above, (xi) any microRNA listed in Tables 4-10 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising:

[13] The urine extract according to [1] above, (xii) any microRNA listed in Table 4-11 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising:

[14] The urine extract according to [1] above, (xiii) any microRNA listed in Table 4-12 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising the compound, the compound being a urine extract of a patient with thyroid cancer;

[15] The urine extract according to [1] above, (xiii) any microRNA listed in Table 4-13 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising the compound of formula (I) and (II), the compound being a urine extract of a patient with cervical cancer.

[16] The urine extract according to [1] above, (xiii) any microRNA listed in Tables 4-14 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising:

[17] The urine extract according to [1] above, (xiii) any microRNA listed in Tables 4-15 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} a urine extract comprising:

[18] A urine extract according to any one of [1] to

[17] above, which contains extracellular vesicles, and the microRNA is contained in the extracellular vesicles, or the microRNA is extracted from the extracellular vesicles.

[19] A method for predicting the likelihood of a subject having cancer in a subject having or suspected of having cancer, comprising: providing a urine extract of the subject; in a urine extract obtained from the subject (i) any microRNA listed in Data S1 or Table 2 ; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Table 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4-15 and predicting the possibility that a subject has cancer using, as an index, the expression level of one or more microRNAs selected from the group consisting of: {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}.

[20] The method according to

[19] above, wherein, in a urine extract obtained from a subject, if the expression level of any one or more microRNAs in each table whose expression level is increased in cancer patients {in each table, the microRNAs may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} is equal to or greater than a first threshold value set for each microRNA, it is indicated that the urine may be urine derived from a cancer patient.

[21] The method according to

[20] above, wherein, in a urine extract obtained from a subject, when the expression level of any one or more microRNAs in each table whose expression level is increased in cancer patients {in each table, the microRNAs may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with any cancer selected from the group consisting of lung cancer, breast cancer, kidney cancer, leukemia, lymphoma, pancreatic cancer, prostate cancer, melanoma, ovarian cancer, thyroid cancer, cervical cancer, colorectal cancer, and endometrial cancer.

[22] The method according to

[20] or

[21] above, wherein the first threshold is a value equal to or lower than the third quartile value of the corresponding microRNA in healthy individuals.

[23] In urine extracts obtained from subjects, miR-17-5p, miR-33a-5p, miR-95-3p, miR-9-5p, miR-155-5p, miR-496, miR-544a, miR-556-5p, miR-577, miR-607, miR-19a-5p, miR-548c-5p, miR-548o -5p, miR-548am-5p″, miR-1278, miR-3117-3p, miR-3128, miR-3139, miR-3145-3p, miR-3 201, miR-4282, miR-548ad-3p, miR-548ag, miR-4471, miR-4678, miR-4699-5p, miR-4704

[20] -

[22] , wherein the method according to any one of

[20] to

[22] above indicates that the urine is likely to have been derived from a patient with lung cancer when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-1245b-5p, miR-5582-5p, miR-5582-3p, miR-5590-5p, miR-548aw, miR-5683, miR-580-5p, miR-1252-3p, miR-8058, and miR-548bb-5p is equal to or greater than a first threshold value set for each microRNA.

[24] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-22-3p, miR-380-5p, miR-93-3p, miR-99a-3p, miR-543, miR-5706, and miR-6739-5p} in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with breast cancer.

[25] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-641, let-7a-3p, miR-1279, miR-548aa, miR-548t-3p, miR-548av-3p, miR-376b-5p, and miR-9851-3p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with kidney cancer.

[26] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-301a-3p and miR-2114-3p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, it is indicated that the urine may be derived from a patient with leukemia.

[27] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-30e-3p, miR-3166, miR-3942-5p, miR-4482-5p, miR-4493, and miR-5008-3p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with lymphoma.

[28] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-16-5p, miR-218-5p, let-7g-5p, miR-195-5p, miR-619-3p, miR-643, miR-502-3p, miR-450b-5p, miR-3974, miR-4771, miR-5009-5p, miR-548at-3p, miR-372-5p, and miR-519d-5p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with pancreatic cancer.

[29] A method according to any one of

[20] to

[22] above, wherein if the expression level of miR-1324 in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, it indicates that the urine may be derived from a patient with prostate cancer.

[30] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-1243 and miR-4715-3p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, it is indicated that the urine may be derived from a patient with gastric cancer.

[31] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-4795-3p, miR-5707, and miR-655-5p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with urothelial cancer.

[32] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-18b-5p, miR-562, miR-582-3p, miR-216b-5p, miR-1251-5p, miR-1252-5p, miR-2053, miR-3915, miR-4418, miR-4659a-3p, miR-651-3p, miR-1468-3p, and miR-9903 in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with melanoma.

[33] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-335-5p, miR-27a-5p, miR-499a-3p, and miR-8084 in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with ovarian cancer.

[34] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-376a-5p, miR-374b-3p, miR-4477b, miR-548am-3p, miR-4536-5p, miR-4639-5p, and miR-4798-3p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with thyroid cancer.

[35] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-143-5p, miR-3182, miR-4746-5p, miR-548ao-3p, miR-514a-5p, miR-376c-5p, miR-376a-2-5p, miR-6773-5p, miR-6807-3p, miR-8065, and miR-301b-5p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with cervical cancer.

[36] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-10b-5p, miR-337-5p, miR-6888-3p, and miR-9983-3p in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, it is indicated that the urine may be derived from a patient having colorectal disease.

[37] The method according to any one of

[20] to

[22] above, wherein, when the expression level of one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} selected from the group consisting of miR-199a-3p, miR-199b-3p, miR-518e-3p, miR-626, miR-548x-3p, miR-4659a-5p, miR-4671-3p, miR-4666b, and miR-8068 in a urine extract obtained from a subject is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient with endometrial cancer.

[38] The method according to any one of

[23] to

[37] above, wherein the first threshold is a value equal to or lower than the third quartile value of the corresponding microRNA in healthy individuals.

[39] The method described in

[19] above, wherein, in a urine extract obtained from a subject, the expression level of any one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} whose expression levels are decreased in cancer patients from each table is equal to or lower than a second threshold set for each microRNA, indicating that the urine may be derived from a patient with thyroid cancer.

[40] A method for predicting the likelihood that a subject is cancer-free in a subject suspected of having or having cancer, comprising: detecting in a urine extract obtained from the subject any of the following genes listed in the table: let-7a-5p, let-7c-5p, let-7d-5p, let-7f-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-21-5p, miR-24-1-5p, miR-26a-5p, miR-26b-5p, miR-31-5p, miR-96-5p, miR-98-5p, miR-99a-5p, miR-100-5p, miR-101-3p, miR-106a-5p, miR-148a-3p, miR-7-5p, miR-181c-5p, miR-182-3p, miR-216a-5p, miR-217-5p, miR-219a-5p, miR-222-3p, miR-1-3p, miR -130a-3p, miR-137-3p, miR-142-5p, miR-144-3p, miR-152-3p, miR-153-3p, miR-9-3p, miR-126-5p, miR-126-3p, miR-127-3p, miR-136-5p, miR-150- 5p, miR-186-5p, miR-190a-5p, miR-200a-3p, miR-302a-5p, miR-30e-5p, miR-362-5p, miR-302b-5p, miR-302b-3p, miR-302c-3p, miR-302d-3p, miR-3 67-3p, miR-376c-3p, miR-369-3p, miR-376a-3p, miR-377-3p, miR-384, miR-409-5p, miR-410-3p, miR-376b-3p, miR-146b-5p, miR-520f-3p, miR-519 c-3p, miR-523-3p, miR-518c-3p, miR-524-3p, miR-518d-3p, miR-499a-5p, miR-505-3p, miR-507, miR-508-3p, miR-514a-3p, miR-455-5p, miR-545-3 p, miR-553, miR-559, miR-561-3p, miR-567, miR-568, miR-569, miR-570-3p, miR-573, miR-582-5p, miR-548a-3p, miR-586, miR-548b-3p, miR-590-5p,miR-592, miR-597-5p, miR-599, miR-606, miR-548c-3p, miR-618, miR-620, miR-621, miR-33b-5p, miR-633, miR-648, miR-651-5p, miR-411-5p, miR- 655-3p、miR-549a-3p、miR-660-5p、miR-542-3p、miR-758-3p、miR-454-3p、miR-802、miR-19b-1-5p、miR-19b-2-5p、miR-28-3p、miR-100-3p、miR-105 -3p、miR-30d-3p、miR-10a-3p、miR-10b-3p、miR-34a-3p、miR-196a-3p、miR-218-1-3p、miR-218-2-3p、miR-221-5p、miR-27b-5p、miR-195-3p、miR-26 a-2-3p、miR-367-5p、miR-374a-3p、miR-340-5p、miR-135b-3p、miR-488-3p、miR-497-3p、miR-455-3p、miR-545-5p、miR-556-3p、miR-576-3p、miR-54 8b-5p、miR-590-3p、miR-548a-5p、miR-628-5p、miR-548d-5p、miR-450b-3p、miR-890、miR-889-3p、miR-875-5p、miR-876-5p、miR-708-3p、miR-190b -5p、miR-873-5p、miR-301b-3p、miR-208b-3p、miR-922、miR-934、miR-944、miR-1185-5p、miR-1283、miR-1179、miR-1183、miR-1206、miR-548e-3p、mi R-548j-5p, miR-548k, miR-1295a, miR-1302, miR-1305, miR-1244, miR-1245a, miR-1256, miR-1258, miR-1261, miR-1262, miR-548n, miR-548m, miR-5 48h-5p、miR-302e、miR-302f、miR-1277-3p、miR-548i、miR-1282、miR-1197、miR-1537-3p、miR-205-3p、miR-1973、miR-2054、miR-759、miR-2115-3p、miR-3115, miR-3118, miR-3121-3p, miR-3123, miR-3129-5p, miR-3134, miR-3135a, miR-544b, miR-3140-3p, miR-548t-5p, miR-3143, miR-548u, miR -3146、miR-3152-3p、miR-3159、miR-3167、miR-3171、miR-548w、miR-3183、miR-3065-5p、miR-4302、miR-4309、miR-4263、miR-4272、miR-4277、miR- 4291、miR-3606-5p、miR-3609、miR-3611、miR-3613-5p、miR-3616-5p、miR-3618、miR-23c、miR-3658、miR-3662、miR-3664-5p、miR-3668、miR-3671、 miR-3672, miR-3674, miR-3683, miR-3684, miR-3686, miR-3689a-5p, miR-3689b-5p, miR-3689e, miR-3912-3p, miR-3914, miR-3920, miR-3923, miR- 3927-3p、miR-3938、miR-548y、miR-3939、miR-548z、miR-548h-3p、miR-4422、miR-548ac、miR-4424、miR-4426、miR-4427、miR-548ae-3p、miR-4445- 5p、miR-4452、miR-4457、miR-4464、miR-548ai、miR-570-5p、miR-548aj-3p、miR-4469、miR-4477a、miR-548ak、miR-4490、miR-4500、miR-4503、miR- 4504, miR-4509, miR-4517, miR-4528, miR-548an, miR-3117-5p, miR-3121-5p, miR-3124-3p, miR-3136-3p, miR-3140-5p, miR-3664-3p, miR-3688-5 p、miR-3942-3p、miR-4474-5p、miR-3976、miR-3977、miR-4636、miR-4662a-5p、miR-4662a-3p、miR-4659b-5p、miR-4663、miR-4662b、miR-4666a-5p、miR-4666a-3p, miR-4668-3p, miR-219b-3p, miR-4671-5p, miR-4677-3p, miR-4679, miR-4680-5p, miR-4680-3p, miR-4683, miR-4693-5p, miR-4693- 3p, miR-4696, miR-4699-3p, miR-4703-5p, miR-4705, miR-203b-3p, miR-4711-5p, miR-4714-3p, miR-4720-3p, miR-4735-5p, miR-4735-3p, miR-474 2-5p、miR-4744、miR-499b-5p、miR-4757-5p、miR-4757-3p、miR-4760-5p、miR-4760-3p、miR-4765、miR-4766-3p、miR-4772-5p、miR-4772-3p、miR-4 774-5p、miR-4774-3p、miR-4777-5p、miR-4777-3p、miR-4778-3p、miR-4782-5p、miR-4782-3p、miR-1245b-3p、miR-4789-5p、miR-4789-3p、miR-4790 -3p、miR-4795-5p、miR-4797-5p、miR-4798-5p、miR-4799-3p、miR-4520-2-3p、miR-5047、miR-548ah-3p、miR-548ao-5p、miR-548ap-5p、miR-548ap- 3p、miR-5186、miR-5191、miR-5197-3p、miR-548aq-5p、miR-548aq-3p、miR-548ar-5p、miR-548ar-3p、miR-5583-5p、miR-5583-3p、miR-5586-5p、miR -548au-5p、miR-5590-3p、miR-5591-5p、miR-548av-5p、miR-5682、miR-5692c、miR-5687、miR-5688、miR-5691、miR-5692a、miR-5697、miR-5700、miR -5701、miR-5692b、miR-450a-1-3p、miR-506-5p、miR-539-3p、miR-561-5p、miR-1271-3p、miR-548g-5p、miR-548x-5p、miR-548aj-5p、miR-1277-5p、miR-513c-3p, miR-1178-5p, miR-3606-3p, miR-6079, miR-6128, miR-548ay-5p, miR-548az-5p, miR-548az-3p, miR-6502-3p, miR-6508-3p , miR-95-5p, miR-215-3p, miR-153-5p, miR-190a-3p, miR-412-5p, miR-520g-5p, miR-510-3p, miR-653-3p, miR-670-3p, miR-548e-5p, miR- 548f-5p, miR-513b-3p, miR-1537-5p, miR-6733-5p, miR-6811-5p, miR-6828-3p, miR-6838-3p, miR-6844, miR-6854-5p, miR-6864-3p, miR- 6866-5p, miR-7153-5p, miR-7153-3p, miR-7154-5p, miR-7159-3p, miR-7160-3p, miR-7161-3p, miR-7705, miR-6516-3p, miR-8053, miR-805 6, miR-8061, miR-8066, miR-8067, miR-8076, miR-181b-2-3p, miR-548ad-5p, miR-548ae-5p, miR-548bb-3p, miR-520e-5p, miR-549a-5p, mi R-147b-5p, miR-9900, miR-548bc, miR-10393-5p, miR-10393-3p, miR-10397-3p, miR-10399-5p, miR-10525-3p, miR-12123, miR-12129, miR The method indicates that the urine is likely to be derived from a patient without cancer when one or more microRNAs selected from the group consisting of miR-12130 and miR-12132 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} are less than a first threshold for microRNAs that are more highly expressed in cancer patients than in non-cancer patients, or are greater than or equal to a second threshold for microRNAs that are less expressed in cancer patients than in non-cancer patients.

[41] A method for predicting the likelihood of a subject having or suspected of having cancer having early-stage cancer, the method comprising predicting the likelihood of the subject having early-stage cancer using, as an indicator, the expression of microRNAs listed in any one of Tables 22-1 and 23-1 to 23-14 in a urine extract of the subject (in each table, the microRNAs may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs).

[42] A method for predicting the possibility that a subject having or suspected of having cancer has early-stage cancer at stage I, comprising predicting the possibility that the subject has early-stage cancer using the expression of microRNAs listed in any one of Tables 22-1 to 22-13 (in each table, the microRNAs may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) as an indicator.

[43] A method for analyzing a urine sample, comprising: contacting the urine sample with nanowires (which may be nanowires in a nanowire-integrated fluidic device having nanowires); extracting the microRNA captured on the nanowire; and and confirming whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; Certain microRNAs (i) any microRNA listed in Data S1 or Table 2 ; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Table 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4-15 and one or more microRNAs selected from the group consisting of: {in each table, each may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} method.

[44] The method according to

[43] above, Certain microRNAs Below (ii)~(xiii): (ii) any microRNA listed in Table 4-1 with a p-value less than 0.005; (iii) any microRNA listed in Table 4-2 with a p-value less than 0.005; (iv) any microRNA listed in Table 4-3 with a p-value less than 0.005; (v) any microRNA listed in Table 4-4 with a p-value less than 0.005; (vi) any microRNA listed in Table 4-5 with a p-value less than 0.005; (vii) any microRNA listed in Tables 4-6 with a p-value less than 0.005; (viii) any microRNA listed in Tables 4-7 with a p-value less than 0.005; (ix) any microRNA listed in Tables 4-8 with a p-value less than 0.005; (x) any microRNA listed in Tables 4-9 with a p-value less than 0.005; (xi) any microRNA listed in Tables 4-10 with a p-value less than 0.005; (xii) any microRNA listed in Tables 4-11 having a p-value of less than 0.005; and (xiii) any microRNA listed in Tables 4-12 with a p-value less than 0.005; (xiv) any microRNA listed in Tables 4-13 with a p-value less than 0.005; (xv) any microRNA listed in Tables 4-14 having a p-value of less than 0.005; and (xvi) any microRNA with a p-value of less than 0.005 listed in Tables 4-15 and one or more microRNAs selected from the group consisting of: {in each table, each may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} method.

[45] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having lung cancer; Certain microRNAs (ii) any microRNA listed in Table 4-1 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} That's the method.

[46] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having breast cancer; Certain microRNAs (iii) any microRNA listed in Table 4-2 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[47] The method according to

[43] or

[44] above, the urine is from a subject with kidney cancer or a subject suspected of having breast cancer; Certain microRNAs (iv) any microRNA listed in Table 4-3 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} That's the method.

[48] ​​The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having leukemia; Certain microRNAs (v) any microRNA listed in Table 4-4 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} That's the method.

[49] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having lymphoma; Certain microRNAs (vi) any microRNA listed in Table 4-5 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[50] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having pancreatic cancer; Certain microRNAs (vii) any microRNA listed in Tables 4-6 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[51] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having prostate cancer; Certain microRNAs (viii) any microRNA listed in Tables 4-7 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[52] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having gastric cancer; Certain microRNAs (ix) any microRNA listed in Tables 4-8 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[53] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having urothelial cancer; Certain microRNAs (x) any microRNA listed in Tables 4-9 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[54] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having melanoma; Certain microRNAs (xi) any microRNA listed in Tables 4-10 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[55] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having ovarian cancer; Certain microRNAs (xii) any microRNA listed in Table 4-11 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[56] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having thyroid cancer; Certain microRNAs (xiii) any microRNA listed in Table 4-12 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[57] The method according to

[43] or

[44] above, the urine is urine from a subject having or suspected of having cervical cancer; Certain microRNAs (xiii) any microRNA listed in Table 4-13 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[58] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having colorectal cancer; Certain microRNAs (xiii) any microRNA listed in Tables 4-14 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[59] The method according to

[43] or

[44] above, the urine is from a subject having or suspected of having endometrial cancer; Certain microRNAs (xiii) any microRNA listed in Tables 4-15 {which may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[60] The method according to any one of

[45] to

[59] above, wherein the microRNA has a p-value of less than 0.005 {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}.

[61] A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA. Certain microRNAs (a) microRNAs listed in any of Tables 22-1 and 23-1 to 23-14 (each table may independently represent one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) That's the method.

[62] The method for analyzing a urine sample according to

[61] above, Certain microRNAs (b) microRNAs listed in any of Tables 22-1 to 22-13 {each table may independently represent 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} That's the method.

[63] The method for analyzing a urine sample according to

[61] above, Certain microRNAs (a) microRNAs listed in any of Tables 22-1 and 23-1 to 23-14 (each table may independently represent one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) The method is a microRNA having an accuracy of 70% or more.

[64] The method for analyzing a urine sample according to

[61] above, Certain microRNAs (a) microRNAs listed in any of Tables 22-1 and 23-1 to 23-14 (each table may independently represent one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) The method is a microRNA having an accuracy of 80% or more.

[65] The method for analyzing a urine sample according to

[61] above, Certain microRNAs (a) microRNAs listed in any of Tables 22-1 and 23-1 to 23-14 (each table may independently represent one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) The method is a microRNA with an accuracy of 90% or more.

[66] The method for analyzing a urine sample according to

[62] above, Certain microRNAs (b) microRNAs listed in any of Tables 22-1 to 22-13 {each table may independently represent 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} The method is a microRNA having an accuracy of 70% or more.

[67] The method for analyzing a urine sample according to

[62] above, Certain microRNAs (b) microRNAs listed in any of Tables 22-1 to 22-13 {each table may independently represent 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} The method is a microRNA having an accuracy of 80% or more.

[68] The method for analyzing a urine sample according to

[62] above, Certain microRNAs (b) microRNAs listed in any of Tables 22-1 to 22-13 {each table may independently represent 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs} The method is a microRNA with an accuracy of 90% or more.

[69] A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; extracting the microRNA captured on the nanowire; and and confirming whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; Certain microRNAs (c) microRNAs listed in any of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 (each table may independently represent one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) That's the method.

[70] The method for analyzing urine according to

[69] above, Certain microRNAs (c) A method in which the microRNA is listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 (which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table), and the microRNA has an accuracy of 70% or more in the table.

[71] The method for analyzing urine according to

[69] above, Certain microRNAs (c) microRNAs listed in any of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 (each table may independently represent one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs) The microRNA in the table has an accuracy of 80% or more.

[72] The method for analyzing urine according to

[69] above, Certain microRNAs (c) microRNAs listed in any of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {{In each table, microRNAs may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more} The microRNA in the table has an accuracy of 90% or more.

[73] A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having nanowires of a metal oxide (e.g., zinc oxide); extracting the microRNA captured on the nanowire; and and confirming whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; Certain microRNAs miR-134-5p, miR-346, miR-564, miR-574-3p, miR-575, miR-632, miR-661, miR-663a, miR-658, miR-297, miR-139-3p, miR-149-3p, miR-20b-3p, miR-431-3p, miR-550a-5p, miR-885-5p, miR-936, miR-937-3p, miR-943, miR-1228-5p, miR-1184, miR-1204, miR-1538, miR-1909-5p, miR-1910-5p, miR -1912-3p,miR-196b-3p,miR-1972,miR-3153,miR-3162-5p,miR-1193,miR-4260,miR-4253,miR-4326,miR-4269,miR-4276,miR-3622a-3p,miR-3646,miR-3652,miR-3180,miR-550b-3p,miR-4428,miR-4433a-3p,miR-4440,miR-4444,miR-4447,miR-4449,miR-4455,miR-3155b,miR-4483,miR-4 498,miR-2392,miR-4535,miR-4539,miR-3173-5p,miR-4529-5p,miR-4638-5p,miR-4655-5p,miR-4685-3p,miR-1343-3p,miR-4701-3p,miR-4717-3p,miR-4725-5p,miR-4726-3p,miR-4732-5p,miR-4738-3p,miR-4748,miR-4750-5p,miR-371b-5p,miR-4436b-5p,miR-4793-3p,miR-5001-3p,mi R-5002-3p, miR-5006-5p, miR-5090, miR-5572, miR-5584-3p, miR-5705, miR-1237-5p, miR-6072, miR-6131, miR-6503-3p, miR-6511b-5p, miR-1296-3p, miR-5189-3p, miR-6728-5p, miR-6729-5p, miR-6736-3p, miR-6738-5p, miR-6738-3p, miR-6740-3p, miR-6753-5p, miR-6754-3p, miR-6756-5p,miR-6759-5p, miR-6765-5p, miR-6768-5p, miR-6772-3p, miR-6773-3p, miR-6787-3p, miR- 6790-5p, miR-6792-5p, miR-6798-5p, miR-6804-3p, miR-6805-5p, miR-6809-3p, miR-6816 -5p, miR-6820-5p, miR-6821-5p, miR-6821-3p, miR-6822-5p, miR-6830-3p, miR-6832-3p, miR-6833-5p, miR-6833-3p, miR-6834-5p, miR-6780b-3p, miR-6854-3p, miR-6862-5p, miR- 6867-5p, miR-6868-3p, miR-6871-5p, miR-6875-3p, miR-6877-5p, miR-6878-3p, miR-6882 -3p, miR-6883-5p, miR-6883-3p, miR-6893-3p, miR-6894-3p, miR-7109-3p, miR-7152-5p, Selected from the group consisting of miR-7160-5p, miR-7843-5p, miR-8059, miR-8077, miR-7977, miR-4485-5p, miR-8485, miR-9718, miR-10396a-5p, miR-10398-5p, miR-10396b-5p, and miR-11400 (ALL), method.

[74] A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having nanowires of a metal oxide (e.g., zinc oxide); extracting the microRNA captured on the nanowire; and and confirming whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; Certain microRNAs let-7e-5p, miR-23a-3p, miR-24-3p, miR-25-3p, miR-28-5p, miR-29a-3p, miR-30a-3p, miR-92a-3p, miR-29b-3p, miR-105-5p, miR-192-5p, miR-199a-5p, miR-129-5p, miR-30c-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-187-3p, miR-205-5p, miR-210-3p, miR-211-5p, miR-212-3p, miR-214 -3p,miR-221-3p,miR-200b-3p,let-7i-5p,miR-15b-5p,miR-23b-3p,miR-27b-3p,miR-138-5p,miR-143-3p,miR-134-5p,miR-146a-5p,miR-154-5p,miR-184,miR-194-5p,miR-34b-5p,miR-34c-5p,miR-299-3p,miR-99b-5p,miR-296-5p,miR-361-5p,miR-370-3p,miR-371a-3p,miR-373-5p,miR -378a-3p,miR-381-3p,miR-382-5p,miR-340-3p,miR-330-3p,miR-328-3p,miR-342-3p,miR-323a-3p,miR-338-3p,miR-325,miR-346,miR-196b-5p,miR-422a,miR-449a,miR-200a-5p,miR-433-3p,miR-323b-5p,miR-484,miR-485-5p,miR-485-3p,miR-486-5p,miR-487a-3p,miR-488-5p,miR-4 89-3p, miR-491-5p, miR-511-5p, miR-202-3p, miR-492, miR-432-5p, miR-494-3p, miR-497-5p, miR-512-5p, miR-512-3p, miR-498-5p, miR-515-5p, miR-515-3p, miR-519e-3p, miR-520a-3p, miR-526b-5p, miR-525-5p, miR-525-3p, miR-517a-3p, miR-517b-3p, miR-519d-3p, miR-521, miR-520d-3p,miR-520g-3p, miR-516b-3p, miR-516a-3p, miR-517c-3p, miR-520h, miR-519a-3p, miR-500a-3p, miR-501-5p, miR-513a-5p, miR-506-3p, miR-509-3p, miR-510-5p, miR-299-5p, miR-18a-3p, miR-493-3p, miR-487b-3p, miR-551a, miR-554, miR-92b-3p, miR-557, miR-558, miR-564, miR-551b-3p, mi R-572,miR-574-3p,miR-575,miR-579-3p,miR-584-5p,miR-589-3p,miR-550a-3p,miR-591,miR-593-5p,miR-595,miR-601,miR-602,miR-603,miR-604,miR-608,miR-609,miR-610,miR-612,miR-614,miR-615-3p,miR-616-5p,miR-617,miR-622,miR-623,miR-628-3p,miR-629-3p,miR-631,miR -632,miR-634,miR-635,miR-636,miR-637,miR-638,miR-639,miR-642a-5p,miR-644a,miR-645,miR-649,miR-650,miR-661,miR-663a,miR-449b-5p,miR-654-5p,miR-657,miR-658,miR-542-5p,miR-363-5p,miR-671-5p,miR-668-3p,miR-454-5p,miR-769-5p,miR-769-3p,miR-766-3p,miR-76 5,miR-770-5p,miR-675-5p,miR-297,let-7d-3p,miR-15a-3p,miR-16-1-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR-26a-1-3p,miR-26b-3p,miR-92a-2-5p,miR-16-2-3p,miR-139-3p,miR-7-1-3p,miR-181a-2-3p,miR-181c-3p,miR-183-3p,miR-187-5p,miR-214-5p,miR-222-5p,miR-200b-5p,miR-15b-3p, miR-30b-3p, miR-124-5p, miR-125b-1-3p, miR-135a-3p, miR-138-2-3p, miR-141-5p, miR-125a-3p, miR-125b-2-3p, miR-138-1-3p, miR-149-3p, miR-185-3p, miR-186-3p, miR-193a-5p, miR-200c-5p, miR-194-3p, miR-106b-3p, miR-29c-5p, miR-219a-2-3p, miR-34b-3p, miR-34c-3p, m iR-99b-3p, miR-296-3p, miR-130b-5p, miR-371a-5p, miR-377-5p, miR-330-5p, miR-342-5p, miR-323a-5p, miR-151a-5p, miR-338-5p, miR-339-3p, miR-335-3p, miR-423-5p, miR-424-3p, miR-18b-3p, miR-20b-3p, miR-431-3p, miR-483-5p, miR-486-3p, miR-146b-3p, miR-193b-5p, miR-500a-5p, mi R-505-5p, miR-508-5p, miR-532-3p, miR-92b-5p, miR-551b-5p, miR-574-5p, miR-589-5p, miR-550a-5p, miR-593-3p, miR-615-5p, miR-625-3p, miR-629-5p, miR-411-3p, miR-654-3p, miR-671-3p, miR-891a-5p, miR-300, miR-892a, miR-874-3p, miR-888-3p, miR-892b, miR-541-5p, miR-541-3p, miR -875-3p,miR-708-5p,miR-147b-3p,miR-744-5p,miR-744-3p,miR-885-5p,miR-885-3p,miR-877-5p,miR-877-3p,miR-887-3p,miR-665,miR-760,miR-920,miR-921,miR-935,miR-936,miR-937-3p,miR-938,miR-939-5p,miR-940,miR-943,miR-1224-5p,miR-1224-3p,miR-1225-5p,miR-1225-3p,miR-1226-5p, miR-1228-5p, miR-1228-3p, miR-1229-3p, miR-1231, miR-1233-3p, miR-1234-3p, miR-1236-3p, miR-1237-3p, miR-1238-3p, miR-513b-5p, miR-513c-5p, miR-320c, miR-1271-5p, miR-1298-5p, miR-1178-3p, miR-1181, miR-1182, miR-1184, miR-1203, miR-663b, miR-1204, miR-1207- 5p,miR-1207-3p,miR-1285-3p,miR-1286,miR-1287-5p,miR-1291,miR-1293,miR-1294,miR-1297,miR-1303,miR-1304-5p,miR-1249-3p,miR-1250-5p,miR-1260a,miR-1263,miR-1265,miR-1266-5p,miR-1268a,miR-1269a,miR-1270,miR-1276,miR-1281,miR-1284,miR-1288-3p,miR-1292-5p,m iR-1306-3p, miR-1307-3p, miR-1321, miR-1322, miR-1825, miR-1468-5p, miR-1469, miR-1470, miR-1471, miR-1538, miR-103b, miR-1908-5p, miR-1909-5p, miR-1909-3p, miR-1910-5p, miR-1911-3p, miR-1912-3p, miR-1913, miR-1914-3p, miR-1915-5p, miR-1915-3p, miR-103a-2-5p, miR-224-3p, miR-365a-5p, miR-196b-3p, miR-449b-3p, miR-2113, miR-1972, miR-1976, miR-2110, miR-151b, miR-449c-5p, miR-762, miR-761, miR-764, miR-548q, miR-2276-3p, miR-711, miR-718, miR-2681-5p, miR-2682-5p, miR-2682-3p, miR-449c-3p, miR-2861, miR-2909, miR-3122, miR-3124-5p, miR-3125,miR-3127-5p,miR-3130-3p,miR-3130-5p,miR-378b,miR-466,miR-3137,miR-3138,miR-3141,miR-3142,miR-1273c,miR-3147,miR-3148,miR-3150a-3p,miR-3151-5p,miR-3153,miR-3074-3p,miR-3154,miR-3155a,miR-3158-3p,miR-3160-3p,miR-3161,miR-3162-5p,miR-3163,miR-3165,miR- 1260b,miR-3170,miR-3173-3p,miR-1193,miR-3174,miR-3175,miR-3176,miR-3178,miR-3180-3p,miR-3185,miR-3186-5p,miR-3186-3p,miR-3187-3p,miR-3189-3p,miR-320e,miR-3191-3p,miR-3192-5p,miR-3193,miR-3194-5p,miR-3195,miR-3196,miR-3197,miR-3198,miR-3199,miR-3200-3 p,miR-514b-5p,miR-514b-3p,miR-3126-3p,miR-3065-3p,miR-4296,miR-4297,miR-378c,miR-4293,miR-4294,miR-4299,miR-4298,miR-4300,miR-4304,miR-4303,miR-4305,miR-4308,miR-4311,miR-4315,miR-4316,miR-4314,miR-4318,miR-4319,miR-4317,miR-4322,miR-4321,miR-4323,mi R-4324,miR-4257,miR-4258,miR-4259,miR-4260,miR-4253,miR-4254,miR-4255,miR-4252,miR-4326,miR-4327,miR-4261,miR-4265,miR-4262,miR-4268,miR-4269,miR-4264,miR-4271,miR-4273,miR-4276,miR-4274,miR-4279,miR-4278,miR-4280,miR-4285,miR-4283,miR-4287,miR-4289,miR-4329, miR-4328, miR-2277-5p, miR-3605-5p, miR-3610, miR-3614-5p, miR-3615, miR-3616-3p, miR-3619-5p, miR-3620-3p, miR-3621, miR-3622a-5p, miR-3622, a-3p,miR-3622b-5p,miR-3646,miR-3648,miR-3649,miR-3650,miR-3651,miR-3652,miR-3654,miR-3655,miR-3657,miR-3659,miR-3660,miR-3661,miR-3663-5p,miR-3663-3p,miR-3665,miR-3666,miR-3667-5p,miR-3675-5p,miR-3675-3p,miR-3677-3p,miR-3678-3p,miR-3679-5p,miR-3679-3 p,miR-3680-3p,miR-3681-3p,miR-3682-3p,miR-3685,miR-3689a-3p,miR-3690,miR-3691-5p,miR-3692-5p,miR-3713,miR-3180,miR-3907,miR-3689b-3p,miR-3689c,miR-3911,miR-3913-5p,miR-3917,miR-3918,miR-3919,miR-3150b-3p,miR-3925-5p,miR-676-5p,miR-3928-3p,miR-3929,mi R-3934-5p,miR-3936,miR-3937,miR-3940-3p,miR-3944-3p,miR-374c-5p,miR-642b-3p,miR-550b-3p,miR-1268b,miR-378e,miR-4420,miR-4421,miR-378g,miR-4425,miR-4428,miR-4429,miR-4430,miR-4431,miR-4433a-3p,miR-4435,miR-4436a,miR-4437,miR-4438,miR-4439,miR-4440,miR -4441,miR-4444,miR-4445-3p,miR-4446-3p,miR-4447,miR-4448,miR-4449,miR-4450,miR-4451,miR-4453,miR-4454,miR-4455,miR-4456,miR-4458,miR-3135b,miR-4462,miR-4463,miR-4465,miR-4466,miR-4467,miR-4470,miR-4472,miR-4473,miR-4474-3p,miR-4475,miR-4476,miR-4478,miR-3689d,miR-3689f,miR-4479,miR-3155b,miR-4481,miR-4483,miR-4484,miR-4486,miR-4487,miR-4488,miR-4489,miR-4491,miR-4492,miR-4494,miR-4495,miR-4497,miR-4498,miR-4502,miR-4505,miR-4506,miR-2392,miR-4507,miR-4508,miR-4510,miR-4511,miR-4513,miR-4514,miR- 4515,miR-4516,miR-4521,miR-4523,miR-4524a-5p,miR-4526,miR-4527,miR-4529-3p,miR-4530,miR-4533,miR-378i,miR-4535,miR-1587,miR-4537,miR-4538,miR-4539,miR-4540,miR-3120-5p,miR-3129-3p,miR-3145-5p,miR-3150a-5p,miR-3152-5p,miR-3074-5p,miR-3157-3p,miR-3158- 5p,miR-3160-5p,miR-3173-5p,miR-3187-5p,miR-3691-3p,miR-3913-3p,miR-3922-5p,miR-3925-3p,miR-3940-5p,miR-3944-5p,miR-4423-5p,miR-4520-5p,miR-4529-5p,miR-3960,miR-3975,miR-4634,miR-4635,miR-4638-5p,miR-4639-3p,miR-4640-5p,miR-4641,miR-4642,miR-4644,miR- 4645-3p,miR-4646-5p,miR-4646-3p,miR-4647,miR-4648,miR-4649-5p,miR-4650-3p,miR-4651,miR-4652-5p,miR-4653-5p,miR-4654,miR-4655-5p,miR-4656,miR-4657,miR-4658,miR-4661-3p,miR-4664-5p,miR-4664-3p,miR-4665-5p,miR-4665-3p,miR-4667-5p,miR-4667-3p,miR-219b-5p,miR-4669, miR-4670-5p, miR-4672, miR-4673, miR-4674, miR-4676-5p, miR-4676-3p, miR-4681, miR-4682, miR-4684-5p, miR-4684-3p, miR-4685-5p, miR-4685-3p, miR-4686, miR-4687-5p, miR-4687-3p, miR-1343-3p, miR-4688, miR-4690-5p, miR-4691-5p, miR-4691-3p, miR-4692, miR-4694-3p ,miR-4695-5p,miR-4697-5p,miR-4697-3p,miR-4698,miR-4700-5p,miR-4700-3p,miR-4701-5p,miR-4701-3p,miR-4706,miR-4707-5p,miR-4707-3p,miR-4708-5p,miR-4708-3p,miR-4709-5p,miR-4709-3p,miR-4710,miR-4711-3p,miR-4712-5p,miR-4713-5p,miR-4713-3p,miR-4716-5p,miR- 4716-3p,miR-3529-5p,miR-4717-5p,miR-4717-3p,miR-4718,miR-4721,miR-4722-5p,miR-4722-3p,miR-4723-3p,miR-4724-5p,miR-4724-3p,miR-4725-5p,miR-4725-3p,miR-4726-5p,miR-4726-3p,miR-4727-3p,miR-4728-3p,miR-4730,miR-4731-5p,miR-4731-3p,miR-4732-5p,miR-4732- 3p,miR-4733-5p,miR-4733-3p,miR-4734,miR-4736,miR-4737,miR-3064-5p,miR-3064-3p,miR-4738-3p,miR-4739,miR-4740-5p,miR-4741,miR-4743-5p,miR-122b-3p,miR-4745-5p,miR-4746-3p,miR-4747-5p,miR-4747-3p,miR-4748,miR-4749-5p,miR-4749-3p,miR-4750-5p,miR-4753-3p,miR-371b-5p, miR-371b-3p, miR-4754, miR-4755-3p, miR-4756-5p, miR-4756-3p, miR-4758-5p, miR-4758-3p, miR-4759, miR-4761-3p, miR-4763-5p, miR-4763-3p, miR-4764-3p, miR-4766-5p, miR-4767, miR-4768-5p, miR-4768-3p, miR-4769-5p, miR-4769-3p, miR-4773, miR-4776-5p, miR-4776 -3p,miR-4778-5p,miR-4780,miR-4436b-5p,miR-4436b-3p,miR-4783-5p,miR-4783-3p,miR-4784,miR-4785,miR-2467-3p,miR-4786-5p,miR-4786-3p,miR-4787-5p,miR-4787-3p,miR-4788,miR-4793-5p,miR-4793-3p,miR-4794,miR-4796-5p,miR-4797-3p,miR-4800-5p,miR-4800-3p,miR-48 01,miR-4804-3p,miR-642a-3p,miR-550a-3-5p,miR-4433a-5p,miR-4482-3p,miR-4999-5p,miR-4999-3p,miR-5000-5p,miR-5001-5p,miR-5001-3p,miR-5002-5p,miR-5002-3p,miR-5004-5p,miR-5004-3p,miR-5006-5p,miR-5006-3p,miR-5007-5p,miR-5008-5p,miR-5010-5p,miR-5088-5p,mi R-5090, miR-5091, miR-5093, miR-5187-5p, miR-5188, miR-5189-5p, miR-5190, miR-5192, miR-5194, miR-5196-5p, miR-5196-3p, miR-5197-5p, miR-4524b-5p, miR-4524b-3p, miR-5571-3p, miR-5100, miR-5572, miR-664b-5p, miR-664b-3p, miR-5580-5p, miR-5580-3p, miR-5581-3p, miR-5584-3p,miR-5585-3p, miR-1295b-3p, miR-5588-5p, miR-5588-3p, miR-5589-5p, miR-5591-3p, miR-5684, miR-5685, miR-5681b, miR-5690, miR-5694, miR-5696, miR-5698, miR-5702, miR-5703, miR-5704, miR-5705, miR-5708, miR-197-5p, miR-204-3p, miR-211-3p, miR-212-5p, miR-301a-5p, miR-345-3 p,miR-584-3p,miR-652-5p,miR-660-3p,miR-1185-2-3p,miR-766-5p,miR-1285-5p,miR-1304-3p,miR-1247-3p,miR-1255b-2-3p,miR-1306-5p,miR-3184-3p,miR-3191-5p,miR-642b-5p,miR-550b-2-5p,miR-365b-5p,miR-1185-1-3p,miR-3190-3p,miR-216a-3p,miR-381-5p,miR-495-5p,miR -503-3p,miR-937-5p,miR-939-3p,miR-1227-5p,miR-1229-5p,miR-1233-5p,miR-1236-5p,miR-1237-5p,miR-1238-5p,miR-3617-3p,miR-3620-5p,miR-3927-5p,miR-3934-3p,miR-4632-5p,miR-4743-3p,miR-5089-3p,miR-5739,miR-5787,miR-6068,miR-6069,miR-6071,miR-6072,miR-6074 ,miR-6075,miR-6076,miR-6078,miR-6080,miR-6081,miR-6083,miR-6085,miR-6086,miR-6088,miR-6089,miR-6090,miR-6124,miR-6125,miR-6126,miR-6127,miR-6129,miR-6130,miR-6131,miR-6132,miR-6133,miR-6134,miR-6165,miR-6499-5p,miR-6499-3p,miR-548ay-3p,miR-6500-5p,miR-6500-3p, miR-6501-5p, miR-6501-3p, miR-6502-5p, miR-6503-3p, miR-6504-5p, miR-6504-3p, miR-6505-3p, miR-6506-5p, miR-6508-5p, miR-6509-5p, miR-6510-5, p,miR-6511a-5p,miR-6512-3p,miR-6513-5p,miR-6513-3p,miR-6514-5p,miR-6514-3p,miR-6515-5p,miR-6515-3p,miR-6715a-3p,miR-6715b-5p,miR-6716-5p,miR-6716-3p,miR-6717-5p,miR-6511b-5p,miR-6511b-3p,miR-6718-5p,miR-6719-3p,miR-6721-5p,miR-6722-5p,miR-6722-3p,mi R-6724-5p, miR-892c-5p, miR-892c-3p, miR-208a-5p, miR-210-5p, miR-128-1-5p, miR-134-3p, miR-370-5p, miR-328-5p, miR-433-5p, miR-487a-5p, miR-489-5p, miR-494-5p, miR-504-3p, miR-487b-5p, miR-579-5p, miR-585-5p, miR-598-5p, miR-619-5p, miR-656-5p, miR-668-5p, miR-1296-3p, m iR-1301-5p, miR-1298-3p, miR-891a-3p, miR-874-5p, miR-889-5p, miR-887-5p, miR-216b-3p, miR-942-3p, miR-1180-5p, miR-1287-3p, miR-1251-3p, miR-1266-3p, miR-1288-5p, miR-1908-3p, miR-1910-3p, miR-3151-3p, miR-3192-3p, miR-500b-3p, miR-3928-5p, miR-1343-5p, miR-5088-3p, mi R-5189-3p, miR-6720-5p, miR-6726-5p, miR-6726-3p, miR-6727-5p, miR-6727-3p, miR-6728-5p, miR-6728-3p, miR-6729-5p, miR-6729-3p, miR-6730-5p, miR-6730-3p, miR-6731-5p, miR-6732-5p, miR-6732-3p, miR-6733-3p, miR-6734-5p, miR-6735-5p, miR-6735-3p, miR-6736-3p, miR-6737-5p,miR-6738-5p, miR-6738-3p, miR-6739-3p, miR-6740-5p, miR-6740-3p, miR-6741-5p, miR-6741-3p, miR-6742-5p, miR-6743-5p, miR-6743-3p, miR-6744-3p, miR-6747-5p, miR-6747-3p, miR-6748-5p, miR-6748-3p, miR-6749-5p, miR-6749-3p, miR-6750-5p, miR-6750-3p, miR-6751-5p, miR-6751- 3p,miR-6752-5p,miR-6752-3p,miR-6753-5p,miR-6754-5p,miR-6754-3p,miR-6755-5p,miR-6755-3p,miR-6756-5p,miR-6756-3p,miR-6758-5p,miR-6758-3p,miR-6759-5p,miR-6759-3p,miR-6760-5p,miR-6760-3p,miR-6761-5p,miR-6762-5p,miR-6762-3p,miR-6763-5p,miR-6763-3p,miR-676 4-5p,miR-6764-3p,miR-6765-5p,miR-6766-5p,miR-6766-3p,miR-6767-5p,miR-6768-5p,miR-6769a-5p,miR-6769a-3p,miR-6770-5p,miR-6770-3p,miR-6771-5p,miR-6772-5p,miR-6772-3p,miR-6773-3p,miR-6774-5p,miR-6774-3p,miR-6775-5p,miR-6776-5p,miR-6776-3p,miR-6777-5p,mi R-6777-3p,miR-6778-5p,miR-6778-3p,miR-6779-5p,miR-6779-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-6782-3p,miR-6783-5p,miR-6783-3p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786-5p,miR-6786-3p,miR-6787-5p,miR-6787-3p,miR-6788-5p,miR-6789-5p,miR-6789-3p,miR-6790-5p, miR-6791-5p, miR-6791-3p, miR-6792-5p, miR-6792-3p, miR-6793-5p, miR-6794-5p, miR-6796-5p, miR-6796-3p, miR-6797-5p, miR-6797-3p, miR-6798-5p, miR-6798-3p, miR-6799-5p, miR-6800-5p, miR-6800-3p, miR-6801-5p, miR-6801-3p, miR-6802-3p, miR-6803-5p, miR-6803- 3p,miR-6804-5p,miR-6804-3p,miR-6805-5p,miR-6805-3p,miR-6806-5p,miR-6807-5p,miR-6808-5p,miR-6809-5p,miR-6809-3p,miR-6810-5p,miR-6810-3p,miR-6812-5p,miR-6813-5p,miR-6813-3p,miR-6814-5p,miR-6815-3p,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-6817-3p,miR-681 8-3p,miR-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821-5p,miR-6821-3p,miR-6822-5p,miR-6822-3p,miR-6823-5p,miR-6823-3p,miR-6824-5p,miR-6824-3p,miR-6825-5p,miR-6825-3p,miR-6826-3p,miR-6827-5p,miR-6829-5p,miR-6829-3p,miR-6830-5p,miR-6830-3p,miR-6831-5p,miR- 6832-5p,miR-6832-3p,miR-6833-5p,miR-6833-3p,miR-6834-5p,miR-6780b-5p,miR-6780b-3p,miR-6836-5p,miR-6836-3p,miR-6837-5p,miR-6838-5p,miR-6839-5p,miR-6840-3p,miR-6842-5p,miR-6842-3p,miR-6843-3p,miR-6845-5p,miR-6845-3p,miR-6846-5p,miR-6846-3p,miR-6847-5p,miR-6847-3p, miR-6848-5p, miR-6848-3p, miR-6849-5p, miR-6849-3p, miR-6850-5p, miR-6850-3p, miR-6851-5p, miR-6852-5p, miR-6852-3p, miR-6853-5p, miR-6854-3p, miR-6855-5p, miR-6855-3p, miR-6856-5p, miR-6856-3p, miR-6857-5p, miR-6858-5p, miR-6858-3p, miR-6859-5p, miR-685 9-3p,miR-6769b-5p,miR-6860,miR-6861-5p,miR-6861-3p,miR-6862-5p,miR-6862-3p,miR-6863,miR-6866-3p,miR-6867-5p,miR-6867-3p,miR-6868-5p,miR-6868-3p,miR-6869-5p,miR-6870-5p,miR-6870-3p,miR-6871-5p,miR-6873-5p,miR-6874-5p,miR-6874-3p,miR-6875-5p,miR-6875 -3p,miR-6876-5p,miR-6876-3p,miR-6877-5p,miR-6877-3p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3p,miR-6881-5p,miR-6882-3p,miR-6883-5p,miR-6883-3p,miR-6884-5p,miR-6884-3p,miR-6885-3p,miR-6886-5p,miR-6886-3p,miR-6887-3p,miR-6888-5p,miR- 6889-5p,miR-6889-3p,miR-6890-5p,miR-6890-3p,miR-6891-5p,miR-6891-3p,miR-6892-5p,miR-6892-3p,miR-6893-5p,miR-6893-3p,miR-6894-5p,miR-6894-3p,miR-6895-5p,miR-6895-3p,miR-7106-5p,miR-7106-3p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-5p,miR-7109-3p,miR-7110-5p, miR-7110-3p, miR-7111-5p, miR-7111-3p, miR-7112-5p, miR-7113-5p, miR-7113-3p, miR-7114-5p, miR-7114-3p, miR-7150, miR-7151-5p, miR-7151-3p, miR-7152-5p, miR-7154-3p, miR-7155-5p, miR-7155-3p, miR-7156-5p, miR-7156-3p, miR-7158-5p, miR-7160-5p, miR-7162-3p, miR-7515, miR-7702, miR-7704, miR-7706, miR-7843-5p, miR-4433b-5p, miR-4433b-3p, miR-1273h-5p, miR-6516-5p, miR-7844-5p, miR-7845-5p, miR-7846-3p, miR-7847-3p, miR-7848-3p, miR-7850-5p, miR-7851-3p, miR-7853-5p, miR-7854-3p, miR-7856-5p, miR-8052, miR-8055, miR-8057, miR -8059,miR-8060,miR-8062,miR-8063,miR-8064,miR-8069,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,miR-8075,miR-8077,miR-8078,miR-8079,miR-8080,miR-8081,miR-8082,miR-8083,miR-8085,miR-8089,miR-128-2-5p,miR-7973,miR-7974,miR-7975,miR-7976,miR-7977,miR-1 249-5p, miR-4485-5p, miR-8485, miR-9500, miR-103a-1-5p, miR-217-3p, miR-135a-2-3p, miR-375-5p, miR-498-3p, miR-9718, miR-9899, ​​miR-9902, miR-1843, miR-9986, miR-10392-5p, miR-10392-3p, miR-10394-5p, miR-10394-3p, miR-10395-5p, miR-10396a-5p, miR-10396a-3p, miR-10397-5p,miR-10398-5p, miR-10398-3p, miR-10400-5p, miR-10400-3p, miR-10401-5p, miR-1 0401-3p, miR-10396b-5p, miR-10396b-3p, miR-10522-5p, miR-10523-5p, miR-1052, miR-12120, miR-12121, miR-12122, miR-12124, miR-12125, miR-12127, miR-12128, and miR-12131; method.

[75] A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having nanowires of a metal oxide (e.g., zinc oxide); extracting the microRNA captured on the nanowire; and and confirming whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; Certain microRNAs miR-105-5p, miR-192-5p, miR-198, miR-129-5p, miR-187-3p, miR-210-3p, miR-212-3p, miR-214-3p, miR-200b-3p, miR-125b-5p, miR-138-5p, miR-134-5p, miR-184, miR-185-5p, miR-206, miR-106b-5p, miR-34c-5p, miR-99b-5p, miR-296-5p, miR-130b-3p, miR-302c-5p, miR-370-3p, miR-373-3p, miR-378a-3p, miR-382-5p, miR-340-3p, miR-342-3p, miR-337-3p, miR-323a-3p, miR-324-5p, miR-346, miR-422a, miR-425-3p, miR-369-5p, miR-323b-5p, miR-409-3p, miR-412-3p, miR-485-5p, miR-485-3p, miR-488-5p, miR-491-5p, miR-202-3p, miR-492, miR-432-3p, miR-494-3p, miR-512-5p, m iR-512-3p, miR-498-5p, miR-520e-3p, miR-515-3p, miR-519c-5p, miR-523-5p, miR-518e-5p, miR-522-5p, miR-519a-5p, miR-519b-5p, miR-526b-5p, miR-525-5p, miR-518f-3p, miR-520b-3p, miR-526a-5p, miR-520c-5p, miR-518d-5p, miR-518c-5p, miR-519d-3p, miR-520d-5p, miR-516b-3p, miR- 516a-3p,miR-501-5p,miR-513a-5p,miR-510-5p,miR-18a-3p,miR-551a,miR-92b-3p,miR-558,miR-564,miR-551b-3p,miR-572,miR-574-3p,miR-575,miR-583,miR-550a-3p,miR-595,miR-596,miR-601,miR-602,miR-604,miR-608,miR-610,miR-612,miR-614,miR-615-3p,miR-616-5p,miR-617,miR-622, miR-623, miR-629-3p, miR-632, miR-636, miR-637, miR-638, miR-639, miR-646, miR-650, miR-661, miR-663a, miR-654-5p, miR-657, miR-658, miR-421, miR-542-5p, miR-363-5p, miR-668-3p, miR-769-3p, miR-766-3p, miR-770-5p, miR-297, let-7d-3p, miR-15a-3p, miR-21-3p, miR-23a-5 p,miR-25-5p,miR-26b-3p,miR-92a-2-5p,miR-30c-2-3p,miR-139-3p,miR-183-3p,miR-187-5p,miR-214-5p,miR-200b-5p,miR-30b-3p,miR-130a-5p,miR-135a-3p,miR-138-2-3p,miR-125a-3p,miR-125b-2-3p,miR-138-1-3p,miR-149-3p,miR-150-3p,miR-185-3p,miR-186-3p,miR-193a-5p,mi R-200c-5p, miR-155-3p, miR-194-3p, miR-34b-3p, miR-34c-3p, miR-296-3p, miR-130b-5p, miR-361-3p, miR-302d-5p, miR-377-5p, miR-342-5p, miR-323a-5p, miR-338-5p, miR-424-3p, miR-18b-3p, miR-20b-3p, miR-431-3p, miR-483-5p, miR-486-3p, miR-193b-5p, miR-505-5p, miR-508-5p, miR-9 2b-5p, miR-551b-5p, miR-574-5p, miR-550a-5p, miR-593-3p, miR-615-5p, miR-625-3p, miR-629-5p, miR-671-3p, miR-891a-5p, miR-300, miR-892b, miR-541-5p, miR-541-3p, miR-744-5p, miR-885-5p, miR-885-3p, miR-877-5p, miR-887-3p, miR-665, miR-760, miR-920, miR-921, miR-935, miR-936,miR-937-3p, miR-938, miR-939-5p, miR-940, miR-943, miR-1224-5p, miR-1224-3p, miR-1225-5p, miR-1225-3p, miR-1226-5p, miR-1228-5p, miR-1228-3p, miR-1231, miR-1233-3p, miR-1237-3p, miR-1238-3p, miR-513b-5p, miR-320b, miR-320c, miR-1271-5p, miR-1301-3p, miR-1298-5p, miR-1178 -3p,miR-1181,miR-1182,miR-1184,miR-1203,miR-1204,miR-1207-5p,miR-1285-3p,miR-1293,miR-1303,miR-1249-3p,miR-1250-5p,miR-548g-3p,miR-1266-5p,miR-1268a,miR-1269a,miR-1270,miR-1276,miR-1292-5p,miR-1306-3p,miR-1307-3p,miR-1321,miR-1468-5p,miR-675-3p,miR- 1469,miR-1470,miR-1471,miR-1538,miR-1908-5p,miR-1909-5p,miR-1909-3p,miR-1910-5p,miR-1912-3p,miR-1913,miR-1914-3p,miR-1915-3p,miR-103a-2-5p,miR-365a-5p,miR-196b-3p,miR-449b-3p,miR-1972,miR-2110,miR-449c-5p,miR-762,miR-670-5p,miR-761,miR-764,miR-2116- 5p,miR-548q,miR-2276-3p,miR-2277-3p,miR-711,miR-718,miR-2682-5p,miR-449c-3p,miR-3122,miR-3124-5p,miR-3126-5p,miR-3130-3p,miR-3130-5p,miR-3131,miR-3132,miR-3133,miR-466,miR-3137,miR-3138,miR-3141,miR-3147,miR-3150a-3p,miR-3151-5p,miR-3153,miR-3074-3p,miR-3155a, miR-3158-3p, miR-3161, miR-3162-5p, miR-3163, miR-3164, miR-3165, miR-1260b, miR-3173-3p, miR-1193, miR-3176, miR-3177-3p, miR-3178, miR-3180-3p, miR-3185, miR-3186-3p, miR-3187-3p, miR-3189-3p, miR-3191-3p, miR-3192-5p, miR-3195, miR-3196, miR-3197, miR-3198, miR-3199, miR-3202, miR-3126-3p, miR-4296, miR-4297, miR-4294, miR-4299, miR-4300, miR-4304, miR-4305, miR-4306, miR-4307, miR-4308, miR-4313, miR-4316, miR-4314, miR-4319, miR-4317, miR-4322, miR-4321, miR-4323, miR-4324, miR-4257, miR-4258, miR-4259, miR-4260, miR-4253, miR -4251,miR-4255,miR-4252,miR-4326,miR-4327,miR-4261,miR-4265,miR-4266,miR-4267,miR-4262,miR-4268,miR-4269,miR-4276,miR-4274,miR-4280,miR-4285,miR-4289,miR-2277-5p,miR-3200-5p,miR-3605-5p,miR-3605-3p,miR-3610,miR-3612,miR-3614-5p,miR-3616-3p,miR-3619- 5p,miR-3621,miR-3622a-5p,miR-3622a-3p,miR-3622b-5p,miR-3646,miR-3648,miR-3650,miR-3651,miR-3652,miR-3654,miR-3655,miR-3659,miR-3660,miR-3663-5p,miR-3663-3p,miR-3665,miR-3667-5p,miR-3667-3p,miR-3675-3p,miR-3677-3p,miR-3679-5p,miR-3679-3p,miR-3682-3p,miR-3685, miR-3689a-3p, miR-3691-5p, miR-3713, miR-3714, miR-3180, miR-3689b-3p, miR-3689c, miR-3917, miR-3918, miR-3150b-3p, miR-3925-5p, miR-3928-3p, miR-3934-5p, miR-3935, miR-3936, miR-3937, miR-3944-3p, miR-3945, miR-550b-3p, miR-1268b, miR-4421, miR-4428, miR-4429, m iR-4430, miR-4431, miR-4433a-3p, miR-4435, miR-4436a, miR-4439, miR-4440, miR-4441, miR-4443, miR-4444, miR-4446-3p, miR-4447, miR-4448, miR-4449, miR-4450, miR-4451, miR-4453, miR-4454, miR-4455, miR-4456, miR-4458, miR-3135b, miR-4462, miR-4463, miR-4465, miR-4466, miR-4467 ,miR-4470,miR-4472,miR-4474-3p,miR-4475,miR-4476,miR-3689d,miR-4479,miR-3155b,miR-4481,miR-4483,miR-4484,miR-4485-3p,miR-4486,miR-4487,miR-4488,miR-4489,miR-4492,miR-4496,miR-4497,miR-4498,miR-4499,miR-4502,miR-4505,miR-4506,miR-2392,miR-4507,miR-45 08,miR-4510,miR-4512,miR-4513,miR-4514,miR-4515,miR-4516,miR-4521,miR-4525,miR-4526,miR-4530,miR-4531,miR-4533,miR-4534,miR-4535,miR-1587,miR-4538,miR-4539,miR-4540,miR-3120-5p,miR-3150a-5p,miR-3074-5p,miR-3156-3p,miR-3160-5p,miR-3162-3p,miR-3173-5p,miR-3187-5p, miR-3619-3p, miR-3922-5p, miR-3940-5p, miR-3944-5p, miR-4520-5p, miR-4529-5p, miR-3960, miR-4634, miR-4635, miR-4638-5p, miR-4639-3p, miR-4640-5p, miR-4642, miR-4646-5p, miR-4647, miR-4648, miR-4650-3p, miR-4651, miR-4652-5p, miR-4653-5p, miR-4653-3p, miR-4654, miR-4655-5p, miR-4657, miR-4658, miR-4664-5p, miR-4664-3p, miR-4665-5p, miR-4665-3p, miR-4667-5p, miR-219b-5p, miR-4669, miR-4670-5p, miR-4673, miR-4674, miR-4676-5p, miR-4681, miR-4682, miR-4684-5p, miR-4684-3p, miR-4685-3p, miR-4687-5p, miR-1343-3p, miR-4688, miR-4690-5p, miR-4690-3p, miR-4691-5p, miR-4692, miR-4695-5p, miR-4700-5p, miR-4701-3p, miR-4706, miR-4707-5p, miR-4707-3p, miR-4708-5p, miR-4708-3p, miR- 203b-5p,miR-4710,miR-4711-3p,miR-4714-5p,miR-4716-5p,miR-4716-3p,miR-4717-5p,miR-4717-3p,miR-4720-5p,miR-4721,miR-4722-3p,miR-4724-5p,miR-4725-5p,miR-4725-3p,miR-4726-3p,miR-4727-3p,miR-4728-5p,miR-4728-3p,miR-4730,miR-4731-3p,miR-4732-5p,miR-4732-3p ,miR-4734,miR-4736,miR-3064-5p,miR-3064-3p,miR-4738-3p,miR-4740-5p,miR-4740-3p,miR-4741,miR-4743-5p,miR-122b-3p,miR-4745-5p,miR-4746-3p,miR-4747-5p,miR-4747-3p,miR-4748,miR-4749-5p,miR-4749-3p,miR-4750-5p,miR-371b-5p,miR-4754,miR-4755-3p,miR-4758-5p,miR-4763-3p, miR-4764-3p, miR-4767, miR-4769-5p, miR-4776-5p, miR-4776-3p, miR-4780, miR-4436b-5p, miR-4436b-3p, miR-4781-5p, miR-4783-5p, miR-4783-3p, miR-4785, miR-2467-3p, miR-4786-5p, miR-4786-3p, miR-4787-5p, miR-4793-3p, miR-4800-5p, miR-4800-3p, miR-4801, miR-4 804-3p,miR-550a-3-5p,miR-4433a-5p,miR-4482-3p,miR-4999-5p,miR-5001-5p,miR-5001-3p,miR-5002-3p,miR-5004-5p,miR-5004-3p,miR-5006-5p,miR-5009-3p,miR-5010-5p,miR-5088-5p,miR-5090,miR-5093,miR-5187-5p,miR-5188,miR-5189-5p,miR-5190,miR-5193,miR-5195-5p,m iR-5196-5p, miR-5571-3p, miR-5100, miR-5572, miR-664b-5p, miR-664b-3p, miR-5580-3p, miR-5581-3p, miR-5584-3p, miR-5585-3p, miR-5587-5p, miR-5588-5p, miR-5588-3p, miR-5589-5p, miR-5685, miR-5681b, miR-5698, miR-5703, miR-5705, miR-197-5p, miR-204-3p, miR-211-3p, miR-301 a-5p, miR-345-3p, miR-584-3p, miR-659-5p, miR-1185-2-3p, miR-766-5p, miR-873-3p, miR-1285-5p, miR-1247-3p, miR-1255b-2-3p, miR-3191-5p, miR-642b-5p, miR-550b-2-5p, miR-365b-5p, miR-1185-1-3p, miR-3190-3p, miR-937-5p, miR-1227-5p, miR-1236-5p, miR-1237-5p, miR-1238-5p,miR-1292-3p, miR-3617-3p, miR-3620-5p, miR-3934-3p, miR-4632-5p, miR-4750-3p, miR-5739, miR-5787, miR-6068, miR-6070, miR-6071, miR-6072, miR-6074, miR-6075, miR-6076, miR-6080, miR-6081, miR-6083, miR-6084, miR-6085, miR-6086, miR-6089, miR-6090, miR-6124, miR-6125, miR-612 6,miR-6127,miR-6129,miR-6130,miR-6131,miR-6132,miR-6133,miR-6134,miR-6165,miR-6500-5p,miR-6500-3p,miR-6501-5p,miR-6501-3p,miR-6503-3p,miR-6504-3p,miR-6508-5p,miR-6509-3p,miR-6511a-5p,miR-6512-3p,miR-6513-5p,miR-6514-5p,miR-6514-3p,miR-6515-5p,miR-651 5-3p, miR-6715b-5p, miR-6716-3p, miR-6717-5p, miR-6511b-5p, miR-6718-5p, miR-6721-5p, miR-6722-5p, miR-6722-3p, miR-6724-5p, miR-210-5p, miR-128-1-5p, miR-134-3p, miR-433-5p, miR-487a-5p, miR-489-5p, miR-504-3p, miR-487b-5p, miR-585-5p, miR-605-3p, miR-619-5p, miR-656-5p ,miR-668-5p,miR-1296-3p,miR-1301-5p,miR-1298-3p,miR-874-5p,miR-887-5p,miR-1180-5p,miR-548j-3p,miR-1250-3p,miR-1266-3p,miR-1288-5p,miR-1908-3p,miR-1910-3p,miR-3192-3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,miR-5088-3p,miR-5189-3p,miR-6720-5p,miR-6726-5p,miR-6727-5p, miR-6728-5p, miR-6728-3p, miR-6729-5p, miR-6729-3p, miR-6730-5p, miR-6730-3p, miR-6731-5p, miR-6731-3p, miR-6732-5p, miR-6734-5p, miR-6735-3p, miR-6736-5p, miR-6736-3p, miR-6737-5p, miR-6738-5p, miR-6738-3p, miR-6740-5p, miR-6740-3p, miR-6741-5p, miR-6742- 5p,miR-6743-5p,miR-6745,miR-6746-5p,miR-6747-5p,miR-6748-5p,miR-6749-5p,miR-6750-5p,miR-6751-5p,miR-6752-5p,miR-6752-3p,miR-6753-5p,miR-6753-3p,miR-6754-3p,miR-6756-5p,miR-6758-5p,miR-6759-5p,miR-6760-5p,miR-6760-3p,miR-6761-5p,miR-6761-3p,miR-6762- 5p,miR-6762-3p,miR-6763-5p,miR-6763-3p,miR-6765-5p,miR-6765-3p,miR-6766-5p,miR-6766-3p,miR-6767-5p,miR-6768-5p,miR-6769a-5p,miR-6770-5p,miR-6770-3p,miR-6772-5p,miR-6772-3p,miR-6773-3p,miR-6774-3p,miR-6776-5p,miR-6776-3p,miR-6777-5p,miR-6777-3p,miR-6 778-5p,miR-6778-3p,miR-6779-3p,miR-6780a-5p,miR-6780a-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-6783-5p,miR-6783-3p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786-5p,miR-6787-5p,miR-6787-3p,miR-6788-5p,miR-6789-5p,miR-6789-3p,miR-6790-5p,miR-6791-5p,miR-6791-3p, miR-6792-5p, miR-6792-3p, miR-6793-5p, miR-6794-5p, miR-6795-5p, miR-6795-3p, miR-6796-5p, miR-6796-3p, miR-6797-5p, miR-6798-5p, miR-6798-3p, miR-6800-5p, miR-6800-3p, miR-6803-3p, miR-6804-5p, miR-6804-3p, miR-6805-5p, miR-6805-3p, miR-6806-5p, miR-6808- 5p,miR-6809-5p,miR-6809-3p,miR-6810-5p,miR-6810-3p,miR-6812-5p,miR-6813-5p,miR-6813-3p,miR-6814-5p,miR-6815-5p,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821-5p,miR-6821-3p,miR-6822-5p,miR-6823-5p,miR-6824-5p,miR-682 5-5p,miR-6827-5p,miR-6829-5p,miR-6829-3p,miR-6830-5p,miR-6830-3p,miR-6831-5p,miR-6832-5p,miR-6832-3p,miR-6833-5p,miR-6833-3p,miR-6834-5p,miR-6780b-5p,miR-6780b-3p,miR-6836-5p,miR-6836-3p,miR-6837-5p,miR-6837-3p,miR-6838-5p,miR-6839-5p,miR-6840-3p,mi R-6842-5p, miR-6843-3p, miR-6845-5p, miR-6845-3p, miR-6846-5p, miR-6847-5p, miR-6847-3p, miR-6848-5p, miR-6849-5p, miR-6849-3p, miR-6850-5p, miR-6850-3p, miR-6852-5p, miR-6852-3p, miR-6854-3p, miR-6855-5p, miR-6855-3p, miR-6856-5p, miR-6856-3p, miR-6857-5p, miR-6859-5p,miR-6859-3p, miR-6769b-5p, miR-6860, miR-6861-5p, miR-6862-5p, miR-6867-5p, miR-6867-3p, miR-6868-3p, miR-6869-5p, miR-6870-5p, miR-6871-5p, miR-6872, -5p,miR-6873-5p,miR-6874-5p,miR-6875-5p,miR-6875-3p,miR-6876-5p,miR-6877-5p,miR-6877-3p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3p,miR-6881-5p,miR-6882-3p,miR-6883-5p,miR-6883-3p,miR-6886-5p,miR-6887-5p,miR-6887-3p,miR-6889-5p,miR-6 891-5p,miR-6891-3p,miR-6892-5p,miR-6892-3p,miR-6893-5p,miR-6893-3p,miR-6894-5p,miR-6894-3p,miR-6895-5p,miR-7106-5p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-3p,miR-7110-5p,miR-7111-5p,miR-7112-5p,miR-7113-5p,miR-7114-5p,miR-7114-3p,miR-7150,miR-71 51-3p,miR-7152-5p,miR-7154-3p,miR-7155-5p,miR-7156-3p,miR-7160-5p,miR-7162-3p,miR-7515,miR-7702,miR-7704,miR-7843-5p,miR-4433b-5p,miR-4433b-3p,miR-1273h-5p,miR-6516-5p,miR-7845-5p,miR-7846-3p,miR-7851-3p,miR-7854-3p,miR-7855-5p,miR-7856-5p,miR-8052,m iR-8057, miR-8059, miR-8060, miR-8063, miR-8064, miR-8069, miR-8070, miR-8071, miR-8072, miR-8073, miR-8074, miR-8075, miR-8077, miR-8078, miR-8079, miR-8082, miR-8085, miR-8087, miR-8088, miR-8089, miR-7974, miR-7975, miR-7976, miR-7977, miR-4485-5p, miR-8485, miR-103a-1-5p,miR-196a-1-3p, miR-217-3p, miR-135a-2-3p, miR-9718, miR-9898, miR-9902, mi R-1843, miR-10226, miR-10392-5p, miR-10392-3p, miR-10394-3p, miR-10395-5p ,miR-10396a-5p,miR-10396a-3p,miR-10398-5p,miR-10398-3p,miR-10400-5p, miR-10400-3p,miR-10401-5p,miR-10401-3p,miR-10396b-5p,miR-10396b-3p,m Selected from the group consisting of miR-10522-5p, miR-10526-3p, miR-10527-5p, miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-3p, miR-3085-5p, miR-3085-3p, miR-6529-5p, miR-9851-5p, miR-12114, miR-12115, miR-12116, miR-12118, miR-12119, miR-12120, miR-12122, miR-12124, miR-12126, miR-12127, and miR-12128 (Hemo), method.

[76] A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having nanowires of a metal oxide (e.g., zinc oxide); extracting the microRNA captured on the nanowire; and and confirming whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; Certain microRNAs let-7b-5p, miR-25-3p, miR-28-5p, miR-29a-3p, miR-29b-3p, miR-105-5p, miR-192-5p, miR-196a-5p, miR-197-3p, miR-198, miR-199a-5p, miR-129-5p, miR-30d-5p, miR-147a, miR-10a-5p, miR-34a-5p, miR-181a-5p, miR-181b-5p, miR-187-3p, miR-199b-5p, miR-204-5p, miR-210-3p, miR-211-5p p,miR-212-3p,miR-214-3p,miR-221-3p,miR-223-3p,miR-200b-3p,miR-23b-3p,miR-30b-5p,miR-122-5p,miR-124-3p,miR-125b-5p,miR-138-5p,miR-125a-5p,miR-134-5p,miR-149-5p,miR-184,miR-185-5p,miR-194-5p,miR-206,miR-106b-5p,miR-34c-5p,miR-299-3p,miR-99b-5p,miR-296 -5p,miR-130b-3p,miR-365a-3p,miR-365b-3p,miR-302c-5p,miR-370-3p,miR-373-5p,miR-373-3p,miR-378a-3p,miR-380-3p,miR-382-5p,miR-340-3p,miR-330-3p,miR-328-3p,miR-342-3p,miR-337-3p,miR-324-5p,miR-324-3p,miR-338-3p,miR-133b,miR-325,miR-346,miR-196b-5p,miR- 422a, miR-425-3p, miR-448, miR-449a, miR-191-3p, miR-200a-5p, miR-369-5p, miR-433-3p, miR-323b-5p, miR-409-3p, miR-412-3p, miR-483-3p, miR-484, miR-485-5p, miR-485-3p, miR-486-5p, miR-488-5p, miR-489-3p, miR-491-5p, miR-202-3p, miR-492, miR-432-3p, miR-494-3p, miR-497-5p,miR-512-5p, miR-498-5p, miR-515-5p, miR-519c-5p, miR-523-5p, miR-518e-5p, miR-522-5p, miR-519a-5p, miR-519b-5p, miR-526b-5p, miR-525-5p, miR-525-3p, miR-518b, miR-518c-5p, miR-519d-3p, miR-520d-3p, miR-520g-3p, miR-516b-5p, miR-516b-3p, miR-516a-3p, miR-518a-3p, miR-502- 5p,miR-504-5p,miR-513a-5p,miR-506-3p,miR-510-5p,miR-532-5p,miR-299-5p,miR-18a-3p,miR-493-3p,miR-487b-3p,miR-551a,miR-554,miR-92b-3p,miR-557,miR-558,miR-563,miR-564,miR-551b-3p,miR-572,miR-574-3p,miR-575,miR-579-3p,miR-580-3p,miR-583,miR-584-5p,miR-58 5-3p,miR-588,miR-589-3p,miR-550a-3p,miR-595,miR-601,miR-603,miR-604,miR-605-5p,miR-608,miR-610,miR-612,miR-614,miR-615-3p,miR-616-5p,miR-617,miR-622,miR-628-3p,miR-629-3p,miR-632,miR-634,miR-635,miR-636,miR-637,miR-638,miR-639,miR-642a-5p,miR-644a,mi R-650, miR-548d-3p, miR-661, miR-663a, miR-449b-5p, miR-654-5p, miR-657, miR-658, miR-421, miR-542-5p, miR-671-5p, miR-668-3p, miR-767-3p, miR-454-5p, miR-769-5p, miR-769-3p, miR-766-3p, miR-765, miR-770-5p, miR-297, let-7b-3p, let-7d-3p, let-7f-1-3p, miR-21-3p, miR-23a-5p,miR-25-5p, miR-26b-3p, miR-92a-2-5p, miR-29b-2-5p, miR-106a-3p, miR-16-2-3p, miR-192-3p, miR-129-1-3p, miR-139-3p, miR-183-3p, miR-187-5p, miR-214-5p, miR-222-5p, miR-200b-5p, miR-15b-3p, miR-30b-3p, miR-124-5p, miR-125b-1-3p, miR-135a-3p, miR-138-2-3p, miR-140-3p, miR -125a-3p,miR-125b-2-3p,miR-127-5p,miR-129-2-3p,miR-138-1-3p,miR-149-3p,miR-150-3p,miR-185-3p,miR-186-3p,miR-193a-5p,miR-200c-5p,miR-194-3p,miR-30c-1-3p,miR-219a-2-3p,miR-34b-3p,miR-34c-3p,miR-99b-3p,miR-296-3p,miR-130b-5p,miR-361-3p,miR-302d-5p,miR -371a-5p,miR-330-5p,miR-342-5p,miR-323a-5p,miR-151a-5p,miR-338-5p,miR-423-5p,miR-424-3p,miR-18b-3p,miR-20b-3p,miR-431-3p,miR-483-5p,miR-486-3p,miR-490-5p,miR-146b-3p,miR-193b-5p,miR-516a-5p,miR-505-5p,miR-508-5p,miR-532-3p,miR-92b-5p,miR-551b-5p,mi R-574-5p, miR-550a-5p, miR-593-3p, miR-615-5p, miR-625-3p, miR-629-5p, miR-654-3p, miR-671-3p, miR-891a-5p, miR-300, miR-874-3p, miR-888-3p, miR-892b, miR-541-5p, miR-541-3p, miR-876-3p, miR-708-5p, miR-147b-3p, miR-744-5p, miR-744-3p, miR-885-5p, miR-885-3p, miR-877-5p,miR-877-3p, miR-887-3p, miR-665, miR-760, miR-920, miR-921, miR-933, miR-935, miR-936, miR-937-3p, miR-938, miR-939-5p, miR-940, miR-943, miR-1224-5p, miR-1224-3p, miR-1225-5p, miR-1225-3p, miR-1226-5p, miR-1226-3p, miR-1227-3p, miR-1228-5p, miR-1228-3p, miR-1229-3p, miR -1231,miR-1233-3p,miR-1234-3p,miR-1236-3p,miR-1237-3p,miR-1238-3p,miR-513b-5p,miR-513c-5p,miR-320b,miR-320c,miR-1271-5p,miR-1301-3p,miR-1298-5p,miR-1178-3p,miR-1181,miR-1182,miR-1184,miR-1202,miR-1203,miR-1204,miR-1207-5p,miR-1207-3p,miR-1285-3p,mi R-1286, miR-1287-5p, miR-1289, miR-1293, miR-1294, miR-1303, miR-1304-5p, miR-1249-3p, miR-1250-5p, miR-1257, miR-1260a, miR-548g-3p, miR-1263, miR-1266-5p, miR-1267, miR-1268a, miR-1269a, miR-1270, miR-1275, miR-1276, miR-1281, miR-1284, miR-1288-3p, miR-1292-5p, miR-125 5b-5p,miR-664a-3p,miR-1306-3p,miR-1307-3p,miR-1321,miR-1322,miR-320d,miR-1825,miR-1468-5p,miR-675-3p,miR-1469,miR-1470,miR-1471,miR-1538,miR-1539,miR-103b,miR-1908-5p,miR-1909-5p,miR-1909-3p,miR-1910-5p,miR-1912-3p,miR-1913,miR-1914-3p,miR-1915-3p,miR-103a-2-5p, miR-365a-5p, miR-196b-3p, miR-449b-3p, miR-2113, miR-1972, miR-1976, miR-2110, let-7a-2-3p, miR-151b, miR-762, miR-670-5p, miR-761, miR-764, miR-2115-5p, miR-2116-5p, miR-2116-3p, miR-548q, miR-2276-3p, miR-2277-3p, miR-2278, miR-711, miR-718, miR-2681-3p, m iR-2682-5p, miR-2682-3p, miR-449c-3p, miR-2909, miR-3116, miR-3119, miR-3120-3p, miR-3122, miR-3124-5p, miR-3125, miR-3126-5p, miR-3127-5p, miR-3130-3p, miR-3130-5p, miR-3131, miR-3132, miR-3133, miR-466, miR-3136-5p, miR-3137, miR-3138, miR-3141, miR-3144-5p, miR-1273c, mi R-3147, miR-3148, miR-3149, miR-3150a-3p, miR-3151-5p, miR-3153, miR-3074-3p, miR-3154, miR-3155a, miR-3156-5p, miR-3157-5p, miR-3158-3p, miR-3160-3p, miR-3161, miR-3162-5p, miR-3163, miR-3165, miR-1260b, miR-3173-3p, miR-1193, miR-3175, miR-3176, miR-3177-3p, miR-3178, mi R-3179,miR-3180-5p,miR-3180-3p,miR-3185,miR-3186-5p,miR-3186-3p,miR-3187-3p,miR-3188,miR-3189-3p,miR-320e,miR-3190-5p,miR-3191-3p,miR-3192-5p,miR-3195,miR-3196,miR-3197,miR-3198,miR-3199,miR-3200-3p,miR-514b-5p,miR-3202,miR-3126-3p,miR-4295,miR-4296,miR-4297,miR-4293,miR-4294,miR-4301,miR-4299,miR-4298,miR-4300,miR-4304,miR-4303,miR-4305,miR-4306,miR-4307,miR-4308,miR-4311,miR-4312,miR-4313,m, iR-4316, miR-4314, miR-4319, miR-4317, miR-4322, miR-4321, miR-4323, miR-4324, miR-4256, miR-4257, miR-4258, miR-4259, miR-4260, miR-4253, miR-4251, miR-4254, miR-4255, miR-4252, miR-4326, miR-4327, miR-4261, miR-4265, miR-4266, miR-4262, miR-2355-5p, miR-4268, miR-4269, miR -4271,miR-4276,miR-4274,miR-4279,miR-4278,miR-4280,miR-4285,miR-4283,miR-4284,miR-4286,miR-4288,miR-4292,miR-4289,miR-4290,miR-4329,miR-2277-5p,miR-3605-5p,miR-3605-3p,miR-3610,miR-3612,miR-3614-5p,miR-3615,miR-3616-3p,miR-3619-5p,miR-3620-3p,miR-36 21,miR-3622a-5p,miR-3622a-3p,miR-3622b-5p,miR-3646,miR-3648,miR-3649,miR-3650,miR-3651,miR-3652,miR-3654,miR-3655,miR-3659,miR-3660,miR-3661,miR-3663-5p,miR-3663-3p,miR-3665,miR-3667-5p,miR-3667-3p,miR-3675-5p,miR-3675-3p,miR-3679-5p,miR-3679-3p,miR -3682-3p,miR-3685,miR-3689a-3p,miR-3691-5p,miR-3692-5p,miR-3713,miR-3714,miR-3180,miR-3689b-3p,miR-3689c,miR-3911,miR-3917,miR-3918,miR-3919,miR-3150b-3p,miR-3922-3p,miR-3925-5p,miR-676-3p,miR-3928-3p,miR-3929,miR-3934-5p,miR-3935,miR-3936,miR-3937,miR-3940-3p, miR-3943, miR-3944-3p, miR-3945, miR-642b-3p, miR-550b-3p, miR-1268b, miR-4420, miR-4421, miR-378g, miR-4425, miR-4428, miR-4429, miR-4430, miR-4431, miR-4433a-3p, miR-4435, miR-4436a, miR-4437, miR-4438, miR-4439, miR-4440, miR-4441, miR-4443, miR-4444, miR-4 445-3p,miR-4446-3p,miR-4447,miR-4448,miR-4449,miR-4450,miR-4451,miR-4453,miR-4454,miR-4455,miR-4456,miR-4458,miR-378h,miR-3135b,miR-4462,miR-4463,miR-4465,miR-4466,miR-4467,miR-4470,miR-4472,miR-4474-3p,miR-4475,miR-4476,miR-4478,miR-3689d,miR-3689f ,miR-4479,miR-3155b,miR-4481,miR-4483,miR-4484,miR-4486,miR-4487,miR-4488,miR-4489,miR-4491,miR-4492,miR-4494,miR-4496,miR-4497,miR-4498,miR-4499,miR-4502,miR-4505,miR-4506,miR-2392,miR-4507,miR-4508,miR-4510,miR-4513,miR-4514,miR-4516,miR-4518,miR -4520-3p,miR-4521,miR-1269b,miR-4522,miR-4523,miR-4524a-3p,miR-4525,miR-4526,miR-4529-3p,miR-4530,miR-4531,miR-4533,miR-4534,miR-378i,miR-4535,miR-1587,miR-4537,miR-4538,miR-4539,miR-4540,miR-3120-5p,miR-3127-3p,miR-3129-3p,miR-3150a-5p,miR-3152-5p,miR-3074-5p, miR-3156-3p, miR-3158-5p, miR-3160-5p, miR-3162-3p, miR-3173-5p, miR-3187-5p, miR-3189-5p, miR-3619-3p, miR-3691-3p, miR-3150b-5p, miR-3922-5p, miR-3940-5p, miR-3944-5p, miR-4423-5p, miR-4446-5p, miR-4520-5p, miR-4529-5p, miR-3960, miR-3972, miR-4633-3p, miR -4634,miR-4635,miR-4638-5p,miR-4639-3p,miR-4640-5p,miR-4640-3p,miR-4641,miR-4642,miR-4644,miR-4646-5p,miR-4646-3p,miR-4647,miR-4648,miR-4649-3p,miR-4650-5p,miR-4650-3p,miR-4651,miR-4652-5p,miR-4653-5p,miR-4653-3p,miR-4654,miR-4655-5p,miR-4656,miR-465 7,miR-4658,miR-4660,miR-4661-3p,miR-4664-5p,miR-4664-3p,miR-4665-5p,miR-4665-3p,miR-4667-5p,miR-4667-3p,miR-219b-5p,miR-4669,miR-4672,miR-4673,miR-4674,miR-4676-5p,miR-4676-3p,miR-4677-5p,miR-4681,miR-4682,miR-4684-5p,miR-4684-3p,miR-4685-5p,miR-4685 -3p,miR-4686,miR-4687-5p,miR-1343-3p,miR-4688,miR-4689,miR-4690-5p,miR-4691-5p,miR-4692,miR-4695-5p,miR-4695-3p,miR-4697-5p,miR-4697-3p,miR-4698,miR-4700-5p,miR-4700-3p,miR-4701-5p,miR-4701-3p,miR-4706,miR-4707-5p,miR-4707-3p,miR-4708-5p,miR-4708-3p,miR-4709-5p, miR-4709-3p, miR-4710, miR-4711-3p, miR-4713-5p, miR-4713-3p, miR-4714-5p, miR-4716-5p, miR-4716-3p, miR-3529-5p, miR-4717-5p, miR-4717-3p, miR-4718, miR-4720-5p, miR-4721, miR-4722-5p, miR-4722-3p, miR-4723-5p, miR-4723-3p, miR-4724-5p, miR-4725-5p, miR-472 5-3p, miR-4726-5p, miR-4726-3p, miR-4727-3p, miR-4728-5p, miR-4728-3p, miR-4730, miR-4731-5p, miR-4731-3p, miR-4732-5p, miR-4732-3p, miR-4734, miR-4736, miR-4737, miR-3064-5p, miR-3064-3p, miR-4738-3p, miR-4740-5p, miR-4740-3p, miR-4741, miR-4743-5p, miR-122b-3p, miR-4745 -5p,miR-4746-3p,miR-4747-5p,miR-4748,miR-4749-5p,miR-4749-3p,miR-4750-5p,miR-4751,miR-4753-5p,miR-4753-3p,miR-371b-5p,miR-371b-3p,miR-4754,miR-4755-3p,miR-4756-5p,miR-4756-3p,miR-4758-5p,miR-4758-3p,miR-4759,miR-4763-5p,miR-4763-3p,miR-4764-5p,miR-47 66-5p,miR-4769-5p,miR-4769-3p,miR-4773,miR-4776-5p,miR-4776-3p,miR-4778-5p,miR-4779,miR-4780,miR-4436b-5p,miR-4436b-3p,miR-4781-5p,miR-4783-3p,miR-4784,miR-4785,miR-2467-3p,miR-4786-5p,miR-4786-3p,miR-4787-5p,miR-4787-3p,miR-4788,miR-4793-3p,miR-4794,miR-4800-5p, miR-4800-3p, miR-4801, miR-4804-3p, miR-642a-3p, miR-550a-3-5p, miR-4433a-5p, miR-4482-3p, miR-4999-5p, miR-5000-5p, miR-5000-3p, miR-5001-5p, miR-5001-3p, miR-5002-5p, miR-5002-3p, miR-5003-3p, miR-5004-5p, miR-5004-3p, miR-5006-5p, miR-5006-3p, miR-5007 -5p,miR-5009-3p,miR-5010-5p,miR-5010-3p,miR-5087,miR-5088-5p,miR-5089-5p,miR-5090,miR-5093,miR-5187-5p,miR-5187-3p,miR-5188,miR-5189-5p,miR-5190,miR-5192,miR-5193,miR-5194,miR-5195-5p,miR-5196-5p,miR-5196-3p,miR-4524b-5p,miR-4524b-3p,miR-5571-5p,mi R-5571-3p,miR-5100,miR-5572,miR-664b-5p,miR-664b-3p,miR-5580-5p,miR-5580-3p,miR-5581-5p,miR-5581-3p,miR-5584-5p,miR-5584-3p,miR-5585-3p,miR-5587-3p,miR-548au-3p,miR-5588-5p,miR-5588-3p,miR-5589-5p,miR-5684,miR-5685,miR-5681b,miR-5690,miR-5694,miR-5 698,miR-5702,miR-5703,miR-5704,miR-5705,miR-5708,miR-197-5p,miR-204-3p,miR-211-3p,miR-345-3p,miR-584-3p,miR-652-5p,miR-660-3p,miR-1185-2-3p,miR-766-5p,miR-873-3p,miR-1285-5p,miR-1304-3p,miR-1247-3p,miR-1255b-2-3p,miR-1306-5p,miR-3184-3p,miR-3191-5p,miR-642b-5p, miR-550b-2-5p, miR-365b-5p, miR-1185-1-3p, miR-3190-3p, miR-98-3p, miR-216a-3p, miR-381-5p, miR-495-5p, miR-503-3p, miR-758-5p, miR-937-, 5p,miR-939-3p,miR-1227-5p,miR-1229-5p,miR-1233-5p,miR-1236-5p,miR-1237-5p,miR-1238-5p,miR-1292-3p,miR-3617-3p,miR-3620-5p,miR-3927-5p,miR-3934-3p,miR-4632-5p,miR-4750-3p,miR-5089-3p,miR-5739,miR-5787,miR-6068,miR-6069,miR-6071,miR-6072,miR-6074,miR- 6075,miR-6076,miR-6077,miR-6080,miR-6081,miR-6083,miR-6084,miR-6085,miR-6086,miR-6089,miR-6090,miR-6124,miR-6125,miR-6126,miR-6127,miR-378j,miR-6129,miR-6130,miR-6131,miR-6132,miR-6133,miR-6165,miR-6499-3p,miR-6500-5p,miR-6500-3p,miR-6501-5p,miR-650 1-3p,miR-6503-5p,miR-6503-3p,miR-6504-5p,miR-6504-3p,miR-6505-3p,miR-6506-5p,miR-6507-3p,miR-6508-5p,miR-6509-5p,miR-6509-3p,miR-6510-5p,miR-6511a-5p,miR-6511a-3p,miR-6512-3p,miR-6513-5p,miR-6513-3p,miR-6514-5p,miR-6514-3p,miR-6515-5p,miR-6515-3p,mi R-6715a-3p, miR-6715b-5p, miR-6716-5p, miR-6716-3p, miR-6717-5p, miR-6511b-5p, miR-6511b-3p, miR-6718-5p, miR-6719-3p, miR-6721-5p, miR-6722-5p, miR-6722-3p, miR-6724-5p, miR-892c-5p, miR-892c-3p, let-7c-3p, miR-210-5p, miR-128-1-5p, miR-134-3p, miR-370-5p, miR-433-5p,miR-329-5p, miR-410-5p, miR-487a-5p, miR-489-5p, miR-494-5p, miR-504-3p, miR-487b-5p, miR-579-5p, miR-585-5p, miR-598-5p, miR-605-3p, miR-619-5p, miR-656-5p, miR-668-5p, miR-1296-3p, miR-1301-5p, miR-1298-3p, miR-874-5p, miR-889-5p, miR-887-5p, miR-1250-3p, miR-1251-3 p,miR-1266-3p,miR-1288-5p,miR-1910-3p,miR-3151-3p,miR-3192-3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,miR-5088-3p,miR-5189-3p,miR-5699-5p,miR-6720-5p,miR-6726-5p,miR-6726-3p,miR-6727-5p,miR-6727-3p,miR-6728-5p,miR-6728-3p,miR-6729-5p,miR-6729-3p,miR-67 30-5p,miR-6730-3p,miR-6731-5p,miR-6731-3p,miR-6732-5p,miR-6732-3p,miR-6734-5p,miR-6735-5p,miR-6735-3p,miR-6736-5p,miR-6736-3p,miR-6737-5p,miR-6737-3p,miR-6738-5p,miR-6738-3p,miR-6739-3p,miR-6740-5p,miR-6740-3p,miR-6741-5p,miR-6741-3p,miR-6742-5p,m iR-6742-3p, miR-6743-5p, miR-6743-3p, miR-6744-5p, miR-6744-3p, miR-6745, miR-6746-5p, miR-6746-3p, miR-6747-5p, miR-6747-3p, miR-6748-5p, miR-6748-3p, miR-6749-5p, miR-6749-3p, miR-6750-5p, miR-6750-3p, miR-6751-5p, miR-6751-3p, miR-6752-5p, miR-6752-3p, miR-6753-5p,miR-6753-3p, miR-6754-5p, miR-6754-3p, miR-6755-5p, miR-6756-5p, miR-6756-3p, miR-6757-5p, miR-6757-3p, miR-6758-5p, miR-6759-5p, miR-6759-3p, miR-6760-5p, miR-6760-3p, miR-6761-5p, miR-6761-3p, miR-6762-5p, miR-6762-3p, miR-6763-5p, miR-6763-3p, miR-6764-3p, miR-6765-5p p,miR-6766-5p,miR-6766-3p,miR-6767-5p,miR-6768-5p,miR-6769a-5p,miR-6769a-3p,miR-6770-5p,miR-6770-3p,miR-6771-3p,miR-6772-5p,miR-6772-3p,miR-6773-3p,miR-6774-5p,miR-6774-3p,miR-6775-5p,miR-6775-3p,miR-6776-5p,miR-6776-3p,miR-6777-5p,miR-6777-3p,miR-67 78-5p,miR-6778-3p,miR-6779-5p,miR-6779-3p,miR-6780a-5p,miR-6780a-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-6782-3p,miR-6783-5p,miR-6783-3p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786-5p,miR-6786-3p,miR-6787-5p,miR-6787-3p,miR-6788-5p,miR-6789-5p,mi R-6789-3p,miR-6790-5p,miR-6790-3p,miR-6791-5p,miR-6791-3p,miR-6792-5p,miR-6792-3p,miR-6793-5p,miR-6793-3p,miR-6794-5p,miR-6794-3p,miR-6795-5p,miR-6795-3p,miR-6796-5p,miR-6796-3p,miR-6797-5p,miR-6797-3p,miR-6798-5p,miR-6798-3p,miR-6799-5p,miR-6799-3p,miR-6800-5p, miR-6800-3p, miR-6801-5p, miR-6801-3p, miR-6802-3p, miR-6803-5p, miR-6803-3p, miR-6804-5p, miR-6804-3p, miR-6805-5p, miR-6805-3p, miR-6806-5p, miR-6807-5p, miR-6808-5p, miR-6809-5p, miR-6809-3p, miR-6810-5p, miR-6810-3p, miR-6812-5p, miR-6812-3p, miR-6813- 5p,miR-6813-3p,miR-6814-5p,miR-6814-3p,miR-6815-5p,miR-6815-3p,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-6817-3p,miR-6819-5p,miR-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821-5p,miR-6821-3p,miR-6822-5p,miR-6822-3p,miR-6823-5p,miR-6823-3p,miR-6824-5p,miR-682 4-3p,miR-6825-5p,miR-6825-3p,miR-6826-3p,miR-6827-5p,miR-6827-3p,miR-6828-5p,miR-6829-5p,miR-6829-3p,miR-6830-5p,miR-6830-3p,miR-6831-5p,miR-6831-3p,miR-6832-5p,miR-6832-3p,miR-6833-5p,miR-6833-3p,miR-6834-5p,miR-6834-3p,miR-6780b-5p,miR-6780b-3p,mi R-6836-5p, miR-6836-3p, miR-6837-5p, miR-6838-5p, miR-6839-5p, miR-6840-5p, miR-6840-3p, miR-6841-3p, miR-6842-5p, miR-6842-3p, miR-6843-3p, miR-6845-5p, miR-6845-3p, miR-6846-5p, miR-6846-3p, miR-6847-5p, miR-6847-3p, miR-6848-5p, miR-6848-3p, miR-6849-5p, miR-6849-3p,miR-6850-5p, miR-6851-5p, miR-6851-3p, miR-6852-5p, miR-6852-3p, miR-6853-5p, miR-6854-3p, miR-6855-5p, miR-6855-3p, miR-6856-5p, miR-6857-5p, miR-6857-3p, miR-6858-5p, miR-6858-3p, miR-6859-5p, miR-6859-3p, miR-6769b-5p, miR-6860, miR-6861-5p, miR-6861-3p, miR-6862- 5p,miR-6862-3p,miR-6863,miR-6865-3p,miR-6867-5p,miR-6867-3p,miR-6868-5p,miR-6868-3p,miR-6869-5p,miR-6870-5p,miR-6870-3p,miR-6871-5p,miR-6871-3p,miR-6872-3p,miR-6873-3p,miR-6874-5p,miR-6875-5p,miR-6875-3p,miR-6876-5p,miR-6876-3p,miR-6877-5p,miR-6877 -3p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3p,miR-6881-5p,miR-6881-3p,miR-6882-5p,miR-6882-3p,miR-6883-5p,miR-6883-3p,miR-6884-5p,miR-6884-3p,miR-6885-3p,miR-6886-5p,miR-6886-3p,miR-6887-5p,miR-6887-3p,miR-6888-5p,miR-6889-5p,miR- 6889-3p,miR-6890-3p,miR-6891-5p,miR-6891-3p,miR-6892-5p,miR-6892-3p,miR-6893-5p,miR-6893-3p,miR-6894-5p,miR-6894-3p,miR-6895-5p,miR-6895-3p,miR-7106-5p,miR-7106-3p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-5p,miR-7109-3p,miR-7110-5p,miR-7110-3p,miR-7111-5p, miR-7111-3p, miR-7112-5p, miR-7113-5p, miR-7113-3p, miR-7114-5p, miR-7114-3p, miR-7150, miR-7151-5p, miR-7151-3p, miR-7152-5p, miR-7152-3p, miR-7, 154-3p,miR-7155-5p,miR-7155-3p,miR-7156-3p,miR-7157-5p,miR-7157-3p,miR-7158-5p,miR-7160-5p,miR-7162-3p,miR-7515,miR-7702,miR-7843-5p,miR-4433b-5p,miR-4433b-3p,miR-1273h-5p,miR-1273h-3p,miR-6516-5p,miR-7845-5p,miR-7846-3p,miR-7847-3p,miR-7850-5p,miR -7851-3p,miR-7854-3p,miR-7855-5p,miR-7856-5p,miR-8052,miR-8054,miR-8057,miR-8059,miR-8060,miR-8062,miR-8063,miR-8064,miR-8069,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,miR-8075,miR-8077,miR-8078,miR-8079,miR-8080,miR-8082,miR-8083,miR-8085,miR-8 086,miR-8087,miR-8088,miR-8089,miR-1199-3p,miR-7975,miR-7976,miR-7977,miR-7978,miR-1249-5p,miR-4485-5p,miR-8485,miR-103a-1-5p,miR-196a-1-3p,miR-135a-2-3p,miR-375-5p,miR-526a-3p,miR-9718,miR-9898,miR-9902,miR-1843,miR-9986,miR-10226,miR-10392-5p,miR -10392-3p,miR-10394-3p,miR-10395-5p,miR-10395-3p,miR-10396a-5p,miR-10396a-3p,miR-10398-5p,miR-10398-3p,miR-10400-3p,miR-10401-5p,miR-10401-3p,miR-10396b-5p,miR-10396b-3p,miR-10522-5p,miR-10523-5p,miR-10526-3p,miR-10527-5p,miR-11181-5p,miR-11181-3p,Selected from the group consisting of miR-11399, miR-11400, miR-11401, miR-3059-5p, miR-3059-3p, miR-3085-5p, miR-3085-3p, miR-6529-5p, miR-12114, miR-12115, miR-12116, miR-12117, miR-12118, miR-12119, miR-12120, miR-12121, miR-12122, miR-12124, miR-12125, miR-12126, miR-12127, miR-12128, miR-12131, and miR-12136 (Uro), method.

[77] The method according to any one of

[73] to

[76] above, comprising detecting five or more types of microRNAs.

[78] The method according to any one of

[73] to

[76] above, comprising detecting 10 or more, 15 or more, or 20 or more types of microRNAs.

[79] The method according to any one of

[73] to

[76] above, wherein the microRNA further satisfies the condition in Tables 4-1 to 4-15 that its expression is increased in cancer patients {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}.

[80] The method according to any one of

[73] to

[76] above, wherein the microRNA further satisfies the condition in Tables 4-1 to 4-15 that its expression is decreased in cancer patients {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}.

[81] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[73] above, wherein the microRNA further satisfies the condition that its expression is increased in cancer patients in Tables 4-1 to 4-15 (in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs); the presence of a microRNA whose expression is higher than a first threshold indicates that the subject from whom the urine was obtained is likely to have early-stage cancer; method.

[82] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[74] above, wherein the microRNA further satisfies the condition that its expression is increased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); the presence of a microRNA whose expression is higher than a first threshold indicates that the subject from whom the urine was obtained is likely to have gastrointestinal cancer; method.

[83] The method according to

[82] above, wherein the subject having or suspected of having cancer is a subject having or suspected of having a digestive system cancer.

[84] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[75] above, wherein the microRNA further satisfies the condition that its expression is increased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); the presence of a microRNA whose expression is higher than a first threshold indicates that the subject from which the urine was obtained may have hematopoietic cancer; method.

[85] The method according to

[84] above, wherein the subject having or suspected of having cancer is a subject having or suspected of having hematopoietic cancer.

[86] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[76] above, wherein the microRNA further satisfies the condition that its expression is increased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); the presence of a microRNA whose expression is higher than a first threshold indicates that the subject from whom the urine was obtained is likely to have urological cancer; method.

[87] The method according to

[86] above, wherein the subject having or suspected of having cancer is a subject having or suspected of having urinary system cancer.

[88] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[73] above, wherein the microRNA further satisfies the condition that its expression is decreased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); the presence of a microRNA whose expression is lower than the first threshold indicates that the subject from which the urine was obtained may have cancer; method.

[89] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[74] above, wherein the microRNA further satisfies the condition that its expression is decreased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); The presence of microRNAs whose expression is lower than that of healthy individuals indicates that the subject from which the urine was obtained may have gastrointestinal cancer. method.

[90] The method according to

[89] above, wherein the subject having or suspected of having cancer is a subject having or suspected of having a digestive system cancer.

[91] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[75] above, wherein the microRNA further satisfies the condition that its expression is decreased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); The presence of microRNAs whose expression is lower than that of healthy individuals indicates that the subject from which the urine was obtained may have hematopoietic cancer. method.

[92] The method according to

[91] above, wherein the subject having or suspected of having cancer is a subject having or suspected of having hematopoietic cancer.

[93] A method for predicting the likelihood of a subject having early-stage cancer in a subject having or suspected of having cancer, comprising: The method according to

[76] above, wherein the microRNA further satisfies the condition that its expression is decreased in cancer patients in Tables 4-1 to 4-15 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); the presence of a microRNA whose expression is lower than a second threshold indicates that the subject from whom the urine was obtained is likely to have urological cancer; method.

[94] The method according to

[93] above, wherein the subject having or suspected of having cancer is a subject having or suspected of having urinary system cancer.

[95] The method according to any one of

[81] to

[87] above, wherein the number of microRNAs showing expression levels higher than the first threshold is five or more.

[96] The method according to any one of

[81] to

[87] above, wherein the number of microRNAs showing expression levels higher than the first threshold is 10 or more, 15 or more, or 20 or more.

[97] The method according to any one of

[88] to

[94] above, wherein the number of microRNAs whose expression is lower than the second threshold is five or more.

[98] The method according to any one of

[88] to

[94] above, wherein the number of microRNAs whose expression is lower than the second threshold is 10 or more, 15 or more, or 20 or more.

[99] Any of the above methods, which is an in vitro method.

[0100] Any of the above methods, wherein the nanowires are nanowires having a metal oxide surface.

[0101] The method according to the above

[0100] , wherein the nanowire is a nanowire having a zinc oxide surface.

[0102] Any of the above methods, wherein the first threshold is any numerical value between two values ​​(statistical values ​​or index values) selected from the group consisting of the mean, median, third quartile, first quartile, and lowest value of the microRNA level in a group of subjects with cancer {wherein the threshold may be different for each microRNA}.

[0103] Any of the above methods, wherein the first threshold is any value between two values ​​selected from the group consisting of the maximum, third quartile, mean, median, and first quartile of the microRNA level in a group of non-cancer subjects {wherein the threshold may be different for each microRNA}.

[0104] Any of the above methods, wherein the first threshold is an arbitrary value (e.g., an intermediate value) between the mean value in a control group with cancer and the mean value in healthy individuals {wherein the threshold may be different for each microRNA}.

[0105] Any of the above methods, wherein the second threshold is any numerical value between two values ​​(statistical values ​​or index values) selected from the group consisting of the mean, median, third quartile, first quartile, and lowest value of the microRNA level in a group of subjects with cancer {wherein the threshold may be different for each microRNA}.

[0106] Any of the above methods, wherein the second threshold is any value between two values ​​selected from the group consisting of the maximum, third quartile, mean, median, and first quartile of the microRNA level in a group of non-cancer subjects {wherein the threshold may be different for each microRNA}.

[0107] Any of the above methods, wherein the second threshold is an arbitrary value (e.g., an intermediate value) between the mean value in the cancer control group and the mean value in the healthy subjects {wherein the threshold may be different for each microRNA}.

[0108] Any of the above methods, wherein the first threshold is a value between the mean value of the microRNA level in a cancer control group and the mean value of the microRNA level in a non-cancer control group {wherein the threshold may be different for each microRNA}.

[0109] Any of the above methods, wherein the first threshold is an intermediate value between the mean value of the microRNA level in a cancer control group and the mean value of the microRNA level in a non-cancer control group {wherein the threshold may be different for each microRNA}.

[0110] Any of the above methods, wherein the second threshold is a value between the mean value of the microRNA level in a cancer control group and the mean value of the microRNA level in a non-cancer control group {wherein the threshold may be different for each microRNA}.

[0111] Any of the above methods, wherein the second threshold is an intermediate value between the mean value of the microRNA level in a cancer control group and the mean value of the microRNA level in a non-cancer control group (wherein the threshold may be different for each microRNA).

[0112] Any of the above methods, wherein the first threshold is a value between the mean and median of a cancer control group.

[0113] Any of the above methods, wherein the first threshold is a value between the mean and the third quartile of a cancer control group.

[0114] Any of the above methods, wherein the first threshold is a value between the mean value and the first quartile value of a control group having cancer.

[0115] Any of the above methods, wherein the first threshold is a value between the first quartile and the lowest value of the cancer control group.

[0116] Any of the above methods, wherein the first threshold is a value between the mean and median of a non-cancer control group.

[0117] Any of the above methods, wherein the first threshold is a value between the mean and the third quartile of a non-cancer control group.

[0118] Any of the above methods, wherein the first threshold is a value between the mean value and the first quartile value of a non-cancer control group.

[0119] Any of the above methods, wherein the first threshold is a value between the third quartile and the maximum value of a non-cancer control group.

[0120] Any of the above methods, wherein the second threshold is a value between the mean and median of a cancer control group.

[0121] Any of the above methods, wherein the second threshold is a value between the mean and the third quartile of a cancer control group.

[0122] Any of the above methods, wherein the second threshold is a value between the mean value and the first quartile value of the cancer control group.

[0123] Any of the above methods, wherein the second threshold is a value between the first quartile and the lowest value of the cancer control group.

[0124] Any of the above methods, wherein the second threshold is a value between the mean and median of a non-cancer control group.

[0125] Any of the above methods, wherein the second threshold is a value between the mean and the third quartile of a non-cancer control group.

[0126] Any of the above methods, wherein the second threshold is a value between the mean value and the first quartile value of a non-cancer control group.

[0127] Any of the above methods, wherein the second threshold is a value between the third quartile and the maximum value of a non-cancer control group.

[0128] The method according to

[61] above, wherein the confirmation is carried out by a miRNA detection method selected from the group consisting of quantitative PCR, a microarray for miRNA detection, RNA-Seq, and multiplex miRNA profiling.

[0129] The method according to any of the above, wherein the nanowires are nanowires in a nanowire-integrated fluidic device having nanowires. [Brief explanation of the drawings]

[0010] Figure 1. Electrostatic capture of urinary EVs using nanowires and subsequent in situ extraction of EV-encapsulated miRNA. Figure 1A shows a schematic diagram of the capture (capture) of urinary EVs using a nanowire-embedded microdevice and the in situ extraction of EV-encapsulated miRNA. Figure 1B shows the embedded nanowires after PDMS pouring, curing, and peeling, as well as a schematic diagram of a vertical cross-sectional FESEM image of the embedded nanowires (nanowires indicated by rods, PDMS indicated by transparent regions) and a schematic inset at the bottom left showing the cross-sectional image. Yellow (light grayscale areas) indicates the nanowires, blue indicates the PDMS, and the white dotted line indicates the edge of the PDMS. The scale bar represents 1 μm. Figure 1C shows a schematic diagram of the cross-sectional image of nanowire growth from the embedded nanowires (nanowire-embedded PDMS), as well as a schematic inset at the bottom left and a vertical cross-sectional image of the nanowire-embedded PDMS. The scale bar represents 1 μm. Figure 1D shows a cross-sectional schematic diagram and a schematic inset at the bottom left of the bonding of nanowire-embedded PDMS to a PDMS substrate with a microfluidic herringbone structure. It also shows a photograph of the nanowire-embedded microfluidic device (where the nanowire-embedded PDMS is bonded to the PDMS substrate with a microfluidic herringbone structure) with polyetheretherketone (PEEK) tubing for the inlet and outlet ports. It also shows a laser microscope image of the microfluidic herringbone structure on the PDMS substrate. The scale bar indicates 1 μm. Figure 1E shows a schematic diagram of the nanowire-embedded device and a top-view FESEM image of the nanowire-embedded PDMS after exposure to lysis buffer. The scale bar indicates 1 μm. Figure 1F shows a schematic diagram of nanowires on a Si substrate and a top-view FESEM image of the nanowires on the Si substrate after exposure to lysis buffer. [Figure 2] In situ extraction of miRNA using a nanowire-integrated microfluidic device. Figure 2A shows a scatter plot of the normalized intensity of miRNA extracted from EVs collected using the nanowire-integrated device of the present disclosure and ultracentrifugation. Figure 2B shows a histogram of miRNA species extracted using the method using the nanowire-integrated device of the present disclosure and ultracentrifugation (n = 3). Figure 2C shows a scatter plot of the normalized intensity of miRNA extracted from EVs collected using the nanowire-integrated device of the present disclosure and a commercially available kit. Figure 2D shows a histogram of miRNA species extracted using the method using the nanowire-integrated device of the present disclosure and ultracentrifugation (n = 3). Error bars indicate the SD of measurements (n = 3). "au" indicates arbitrary units. Figure 3: EV collection on nanowires. Figure 3A is a schematic diagram of the experimental steps and calculation of collection efficiency. Figure 3B shows the size distribution of free floating particles in unprocessed urine. Error bars indicate SD for measurements (n = 3). Figure 3C shows the size distribution of free floating particles in the flow-through fraction of urine processed with the nanowire-integrated device of the present disclosure and in ultracentrifuged urine. Error bars indicate SD for measurements (n = 3). Figure 3D shows fluorescently (RKH26)-labeled EVs collected on nanowires. PKH26-labeled EVs are shown on the nanowires. The scale bar indicates 500 μm. Figure 3E shows an FESEM image of nanowires after introduction of PKH26-labeled EVs. The white arrow indicates collected EVs. The scale bar indicates 200 nm. Figure 3F shows the results of detecting EVs on nanowires and on a 96-well plate using antibodies against CD63 or CD81. The measured concentration of free floating matter in urine was 1.4 x 10 8 ml -1 "ND" indicates that no fluorescence was observed. The dotted line indicates a signal level of 3 SD above background. Error bars indicate the SD for measurements (n=24 for nanowires; n=3 for 96-well plates). [Figure 4] Results of in situ extraction of cancer-related miRNAs using the nanowire-integrated device are shown. Figure 4 shows heat maps of miRNA expression arrays for urine samples from donors without cancer, donors with lung cancer, donors with liver cancer, donors with bladder cancer, and donors with prostate cancer. A color gradient based on signal intensity is used to intuitively understand the expression of each miRNA and compare them between groups. A logarithmic signal intensity of 5 is black; 2 or less is blue; and 8 or more is yellow. Each column in the heat map represents the logarithmic signal intensity of a miRNA (specific values ​​are shown in Data S1). [Figure 5] Downregulation and overexpression of the miRNAs selected from Figure 4 are shown between non-cancer donors and donors with various cancers. The extracted miRNAs were selected so that the second largest logarithmic signal intensity in one group was greater than the second smallest logarithmic signal intensity in the other group. The symbols "-" and "+" indicate non-cancer donors and cancer donors, respectively. The double line on the left indicates that the smallest logarithmic signal intensity in one group was greater than the largest logarithmic signal intensity in the other group. Otherwise, it indicates that one logarithmic signal intensity was higher or lower than the other. Figure 6 shows a schematic diagram of the fabrication process for nanowires embedded in PDMS. Figures 6a-g show the nanowires embedded in PDMS through lithography and PDMS curing processes. The components include a Si substrate, OFPR8600 photoresist, a Cr layer, nanowires, and PDMS. Figure 6a shows the Si substrate prepared, Figure 6b shows the photoresist being deposited, Figure 6c shows the Cr layer being deposited, Figure 6d shows the photoresist being removed, and Figure 6e shows the nanowires growing from the Cr layer. Figure 6f shows the PDMS pouring and curing process, and Figure 6g shows the cured PDMS layer being peeled off from the substrate. Figure 6h shows the embedded nanowires after PDMS pouring, curing, and peeling. Figure 6i shows the process of growing nanowires from the embedded nanowires. Figure 6j shows the process of bonding the nanowire-embedded PDMS substrate to a microfluidic herringbone-structured PDMS substrate. [Figure 7] Regarding the incorporation of nanowires into PDMS. Figure 7a is an FESEM image from the top of the nanowires. The scale bar is 1 μm. Figure 7b shows the diameter distribution of the nanowires. The average diameter of the nanowires was 150 nm. Figure 7c shows the distribution of the spacing between the nanowires. The spacing was defined as the shortest distance between two nanowires and was determined from SEM images of the cross-section. The average spacing between the nanowires was 200 nm. Figure 8 shows FESEM images and corresponding EDS elemental mapping of a PDMS substrate without nanowires, a PDMS substrate with embedded nanowires, and a nanowire-embedded PDMS substrate. Figures 8a–c show FESEM images of vertical cross sections of a PDMS substrate without nanowires, a PDMS substrate with embedded nanowires, and a PDMS substrate with embedded nanowires. Figures 8d–f show elemental mapping corresponding to the FESEM images of the cross sections in Figures 8a–c. Si and Zn are represented in blue (dark areas) and green (arrowheads and light areas), respectively. Figure 8e shows a small amount of nanowires (green) exposed on the surface of the PDMS substrate (blue). Figure 8f also shows an increase in the thickness of the nanowires. Figure 8g shows an FESEM image of the top view of the PDMS substrate with embedded nanowires. Figure 8h shows EDS elemental mapping corresponding to the FESEM image of the top view of Figure 8g. Si and Zn are represented in blue and green (scattered light areas in the grayscale). Figure 9: Mechanical stability of embedded and unembedded nanowires. Figures 9a and 9b are schematic diagrams of nanowires embedded in PDMS and nanowires on a Si substrate before exposure to lysis buffer. The components include nanowires, PDMS, a Si substrate, and a Cr layer. The unembedded nanowires were fabricated on a thermally oxidized Cr layer on a Si substrate. Figures 9c and 9d are top-view FESEM images of nanowires embedded in PDMS and nanowires on a Si substrate, respectively. The scale bar represents 1 μm. Figures 9e and 9f are FESEM images of nanowires embedded in PDMS and nanowires on a Si substrate, respectively, after exposure to lysis buffer. The scale bar represents 1 μm. After exposure to lysis buffer, the nanowires on the Si substrate delaminated, whereas the nanowires embedded in PDMS did not. Figure 10 shows an example of a urinary miRNA extraction process using a nanowire-integrated device, ultracentrifugation, and a commercially available kit. Figure 10a shows the experimental procedure for microarray analysis of miRNA expression. Figure 10b shows the experimental procedure for small RNA quantification using the Qubit™ microRNA assay kit (Thermo Fisher Scientific). After miRNA extraction using various methods, RNA purification and small RNA quantification were performed. Figure 10c shows the quantification of small RNA using various methods. Because the Qubit™ microRNA assay kit (Thermo Fisher Scientific) can quantify not only miRNA but also small RNA (~20 nucleotides or base pairs), the Y-axis represents the concentration of small RNA. These data indicate that the washing step did not affect the RNA recovery efficiency. Error bars indicate SD for measurements (N ≥ 3). [Figure 11] EDS elemental mapping of FESEM and STEM images of a single nanowire. Zn, O, and Al are shown in green, red, and orange, respectively. Figure 11a shows a ZnO-only nanowire. The scale bar indicates 500 nm. Figure 11b shows a ZnO / Al2O3 core-shell nanowire. The scale bar indicates 500 nm. In Figure 11b, Al is seen covering the Zn core. Figure 11c shows a ZnO / Al2O3 core-shell nanowire. The scale bar indicates 100 nm. In Figure 11b, Al is seen covering the Zn core, and O is seen overlapping with Al and Zn. [Figure 12] Anti-CD9 antibody detection of EVs on ZnO nanowires, ZnO / Al2O3 core-shell nanowires, and nanowire-free surfaces. The dotted lines indicate signal intensities of 3 SD above background. The error bars represent the standard deviation (SD) for measurements of ZnO nanowires, ZnO / Al2O3 core-shell nanowires, and nanowire-free surfaces (n = 40, 24, and 24, respectively). Points on the graph represent 10 9 / mL and 10 10The figure shows the signal intensity of miRNA extracted from the surfaces of ZnO nanowires, ZnO / Al2O3 core-shell nanowires, and no nanowires for a sample with an EV concentration of 1 / mL. After EV introduction, these three devices were perfused with PBS to remove any EVs that were not collected. The first device contained ZnO nanowires, the second device contained ZnO / Al2O3 core-shell nanowires, and the third device contained no nanowires. A 1% BSA solution was introduced into these devices and allowed to stand for 15 minutes. After rinsing the devices with PBS, mouse anti-human CD9 antibody (10 μg / mL, Abcam, Plc.) was introduced into each device and then allowed to stand for 15 minutes. CD9 is known to be a membrane protein expressed on exosomes. Additionally, each device was washed with PBS, and AlexaFluor 488-labeled goat polyclonal anti-mouse IgG antibody (5 μg / mL, Abcam, Plc.) was introduced into each device and then allowed to stand for 15 minutes. Finally, each device was washed with PBS, and the fluorescence intensity was observed under a fluorescence microscope (Olympus, Co. Ltd.). The ZnO nanowires effectively collected EVs, whereas the ZnO / Al2O3 core-shell nanowires only collected a small amount of EVs. This suggests the importance of the surface charge of the nanowires. [Figure 13] Zeta potential of urinary EVs. The zeta potential of EVs was measured using a dynamic light scattering device (Zetasizer Nano-ZS, Malvern Instruments, Ltd.). The average zeta potential of EVs was -28 mV. [Figure 14] Size distribution of EVs recovered by ultracentrifugation. Figure 14 also shows the presence of EV-free miRNA recovered on the nanowire. In Figure 14a, the concentration of recovered EVs was 1.6 x 10 9 mL -1The error bars indicate the standard deviation for measurements (n = 3). Figure 14b shows the amount of recovered and released miRNA by quantitative reverse transcription polymerase chain reaction (qRT-PCR). 100 nM miRNA (sequence: miRNA(sequence,uugcauagucacaaaagugauc)) was used as EV-free miRNA. "Untreated" indicates the amount of 100 nM miRNA. The recovery rates for the microchannels with and without nanowires were 100% and 23%, respectively. [Figure 15] Size distribution of free floating particles in urine. The size distribution and concentration of free floating particles in urine were measured using a nanoparticle detector (qNano, Meiwafosis Co., Ltd.) equipped with a 100 nm nanopore membrane (NP100, Meiwafosis Co., Ltd.). Figure 15a shows data for free floating particles in untreated urine, with a concentration of 1.4 x 10 12 mL -1 Figure 15b shows data for free floating matter in the flow-through fraction of urine processed by the nanowire-integrated device, with a concentration of 2.4 x 10 10 mL -1 (Capture efficiency was 99%). Figure 15c shows data on free floating matter in the flow-through fraction of urine treated with a nanowire-incorporated device without the herringbone structure, with a concentration of 4.3 × 10 11 mL -1 (capture efficiency was 61%). [Figure 16] Schematic diagram and photographs (A-C) of the microRNA extraction system used in this study, the number of miRNAs detected (D), the number of miRNAs showing significant differences between the urine of lung cancer patients and healthy subjects (E), ROC curve (F) based on data obtained by randomly dividing patients and healthy subjects into 20 groups, deriving a discriminant formula using logistic regression from the results of 19 randomly selected groups, and performing 20 cycles of prediction for the remaining group, and a plot (G) of the cancer risk for each subject, divided by stage, with the value derived by the discriminant formula (Cancer risk) on the vertical axis. [Figure 17] Shows (A) the weighting coefficients for miRNAs with absolute values ​​of the weighting coefficient greater than 0.01 in the discrimination formula obtained in Figure 16, (B) a heat map created from the relationship between log2 (fluorescence intensity) and the miRNAs shown in Figure 17A above, and (C) the accuracy, sensitivity, and specificity of lung cancer prediction using all miRNAs, as well as the accuracy, sensitivity, and specificity of lung cancer prediction using miRNAs with absolute values ​​of the weighting coefficient greater than 0.05. [Figure 18] Results of lung cancer prediction for stage I patients (A and B), stage II patients (C and D), stage III patients (E and F), and stage IV patients (G and H) are shown. [Figure 19] The relationship between the number of miRNAs detected in lung cancer tissues and urine of lung cancer patients (A) and the intensity of tissue expression of miRNAs with absolute values ​​of weighting coefficients greater than 0.5. [Figures 20-1 to 20-217] ROC curves for predicting human lung cancer using a single miRNA. [Figures 21-1 to 21-78] ROC curves for predicting human breast cancer using a single miRNA are shown. [Figures 22-1 to 22-46] ROC curves for predicting human kidney cancer using a single miRNA. [Figures 23-1 to 23-25] ROC curves for predicting human leukemia using a single miRNA. [Figures 24-1 to 24-65] ROC curves for predicting human lymphoma using a single miRNA. [Figures 25-1 to 25-68] ROC curves for predicting human pancreatic cancer using a single miRNA are shown. [Figures 26-1 to 26-18] ROC curves for predicting human prostate cancer using a single miRNA. [Figures 27-1 to 27-49] ROC curves for predicting human gastric cancer using a single miRNA are shown. [Figures 28-1 to 28-56] ROC curves for predicting human urothelial cancer using a single miRNA are shown. [Figures 29-1 to 29-39] ROC curves for predicting human melanoma using a single miRNA. [Figures 30-1 to 30-28] ROC curves for predicting human ovarian cancer using a single miRNA are shown. [Figures 31-1 to 31-130] ROC curves for predicting human thyroid cancer using a single miRNA. [Figures 32-1 to 32-57] ROC curves for predicting human cervical cancer using a single miRNA. [Figures 33-1 to 33-44] ROC curves for predicting human colorectal cancer using a single miRNA. [Figures 34-1 to 34-84] ROC curves for predicting human endometrial cancer using a single miRNA. Specific Description of the Invention

[0011] As used herein, "subject" refers to a subject of a urine test. The subject may be an animal. The subject may be a reptile, mammal, or amphibian. The mammal may be a dog, cat, cow, horse, sheep, pig, hamster, rat, squirrel, or primate, such as a monkey, gorilla, chimpanzee, bonobo, or human. The subject may particularly be a human.

[0012] As used herein, "urine" refers to a liquid excretory product produced by the kidneys. Urine may be either urine excreted externally via the urethra or urine accumulated in the bladder. Urine may be extracted or collected from the body using an extractor such as a syringe. As used herein, urine may be, but is not limited to, urine from reptiles, mammals, or amphibians. Mammals may include dogs, cats, cows, horses, sheep, pigs, hamsters, mice, squirrels, and primates such as monkeys, gorillas, chimpanzees, bonobos, and humans. "Urine" may be urine from a healthy subject, urine from a subject with a specific disease (e.g., a cancer selected from lung cancer, liver cancer, pancreatic cancer, bladder cancer, and prostate cancer), or urine from a subject suspected of having a specific disease. "Urine" may be used as is, or may be a diluted or concentrated liquid. "Urine" may also be urine samples to which additives have been added. The additives may include, for example, stabilizers and pH adjusters. The "urine" may be frozen urine.

[0013] As used herein, "microRNA" (also referred to as "miRNA") refers to a type of non-coding RNA (ncRNA) that is not thought to encode proteins. MicroRNAs are matured by processing their precursors. Mature microRNAs are known to be approximately 20 to 25 bases in length. Human microRNAs are designated "hsa" (hsa is omitted in all examples herein because human microRNAs are measured, but the results for human microRNAs are disclosed). Precursors are designated "mir" and mature microRNAs are designated "miR." Numbers are assigned in the order of identification, and similar sequences are indicated by a lowercase letter after the number. When a precursor is derived from both the 5' end and the 3' end, the microRNA derived from the 5' end is designated "5p," and the one derived from the 3' end is designated "3p." These symbols and numbers are connected by a hyphen. Mature microRNAs may be double-stranded. As used herein, miRNA names, with or without the has- prefix, are stated to explicitly include human miRNAs.

[0014] As used herein, "extracellular vesicles" (also referred to as "EVs") are vesicles released from cells, including those released during apoptosis and those released from healthy cells. Extracellular vesicles are broadly classified into exosomes, microvesicles (MVs), and apoptosis bodies based on their size and surface markers. Exosomes typically have a diameter of 40-120 nm and may express one or more molecules selected from the group consisting of Alix, Tsg101, CD9, CD63, CD81, and flotillin. Microvesicles typically have a diameter of 50-1,000 nm and may express one or more molecules selected from the group consisting of integrins, selectins, and CD40. Apoptotic bodies typically have a diameter of 500-2,000 nm and may express one or more molecules selected from the group consisting of annexin V and phosphatidylserine. Exosomes can contain proteins and nucleic acids (e.g., mRNA, miRNA, ncRNA). Microvesicles can contain proteins and nucleic acids (e.g., mRNA, miRNA, ncRNA). Apoptotic bodies are thought to contain fragmented nuclei and organelles.

[0015] As used herein, the term "extract" refers to an extracted substance in which certain components are more concentrated than before extraction. As used herein, the term "urine extract" refers to a substance extracted from urine in which certain components (particularly microRNAs) are more concentrated than in urine before extraction. A urine extract may be an aqueous solution (solution or suspension) or a solid obtained by drying it. A urine extract from which components other than extracellular vesicles and nucleic acids in urine have been substantially removed is sometimes referred to as a purified urine product. A urine extract may contain a surfactant (preferably a nonionic surfactant). A urine extract may contain surfactant and debris of extracellular vesicles (e.g., exosomes and / or microvesicles). A urine extract may be free of, or substantially free of, one or more components selected from the group consisting of surfactant and debris of extracellular vesicles (e.g., exosomes and / or microvesicles). The urine extract may further contain a stabilizer (e.g., a nucleic acid stabilizer) and / or a pH adjuster (e.g., a buffer). The urine extract may contain a salt. The urine extract may contain one or more urinary components selected from the group consisting of urea, creatinine, uric acid, ammonia, urobilin, riboflavin, urinary protein, glucose, and urinary hormones (e.g., chorionic gonadotropin) (each independently at a concentration of 50% or less, 40% or less, 30% or less, 20% or less, 10% or less, 5% or less, 4% or less, 3% or less, 2% or less, 1% or less, 1×10 or less of the concentration in urine). -1 % or less, 1×10 -2 % or less, or 1×10 -3% or less}. The pH of the urine extract may be greater than or equal to a value such as 2, 3, 4, or 5. The pH of the urine extract may be less than or equal to a value such as 10, 9, 8, 7, 6, or 5. In the present disclosure, the urine extract comprises microRNAs. In the present disclosure, the urine extract may comprise enriched microRNAs or a group thereof. In the present disclosure, the urine extract may comprise microRNAs extracted by the extraction methods described herein. In the present disclosure, the urine extract may comprise at least one or all of the microRNAs listed in Data S1 (or Table 3 disclosing Data S1). In the present disclosure, a urine extract can be obtained by contacting urine with nanowires having a positively charged surface (e.g., nanowires having a surface of at least one material selected from the group consisting of ZnO, SiO2, Li2O, MgO, Al2O3, CaO, TiO2, Mn2O3, Fe2O3, CoO, NiO, CuO, Ga2O3, SrO, In2O3, SnO2, Sm2O3, and EuO) in the pH environment of urine, followed by washing as necessary and extraction with a buffer solution containing a nonionic surfactant or the like (a urine extract obtained in this manner may be referred to as the "urine extract of the present disclosure"). The pH of urine can also be adjusted before, after, or during contact between urine and the nanowires so that the surface charge of the nanowires is positive. Urine extracts are suitable for nucleic acid analysis.

[0016] As used herein, "in situ extraction" refers to the use of a nanowire-integrated microfluidic device to disrupt EVs captured on a nanowire and extract small RNAs (e.g., microRNAs) "in situ," or to the extraction of small RNAs (e.g., microRNAs) captured on a nanowire from the nanowire into solution.

[0017] As used herein, "free," when used in the context of the form in which microRNAs exist in urine, means that the microRNAs are not encapsulated in extracellular vesicles and are present in a state in which the microRNAs are not associated with extracellular vesicles. As used herein, "encapsulated," when used in the context of the form in which microRNAs exist in urine, means that the microRNAs are incorporated into extracellular vesicles (either completely encapsulated or partially encapsulated).

[0018] As used herein, "nanowire" generally refers to a rod-shaped structure having a cross-sectional shape and diameter on the order of nanometers (e.g., a diameter of one to several hundred nanometers). The size of the nanowire is not particularly limited, but may be, for example, 1 nm, 5 nm, 10 nm, 15 nm, 20 nm, 25 nm, 30 nm, 40 nm, 50 nm, 60 nm, 70 nm, 80 nm, 90 nm, 100 nm, 105 nm, 110 nm, 115 nm, 120 nm, 125 nm, 130 nm, 135 nm, 140 nm, 145 nm, 150 nm, 155 nm, 160 nm, 165 nm, 170 nm, 175 nm, 180 nm, 185 nm, 190 nm, or 195 nm. 、The wavelength may be 200 nm, 210 nm, 220 nm, 230 nm, 240 nm, 250 nm, 260 nm, 270 nm, 280 nm, 290 nm, 300 nm, 310 nm, 320 nm, 330 nm, 340 nm, 350 nm, 360 nm, 370 nm, 380 nm, 390 nm, 400 nm, 410 nm, 420 nm, 430 nm, 440 nm, 450 nm, 460 nm, 470 nm, 480 nm, or 490 nm, or may be greater than one lower limit selected from the group of values. The size of the nanowire is also not particularly limited, and may be, for example, 1000 nm, 990 nm, 980 nm, 970 nm, 960 nm, 950 nm, 940 nm, 930 nm, 920 nm, 910 nm, 900 nm, 890 nm, 880 nm, 870 nm, 860 nm, 850 nm, 840 nm, 830 nm, 820 nm, 810 nm, 800 nm, 790 nm, 780 nm, 770 nm, 760 nm, 750 nm, The nanowire diameter may be 740 nm, 730 nm, 720 nm, 710 nm, 700 nm, 690 nm, 680 nm, 670 nm, 660 nm, 650 nm, 640 nm, 630 nm, 620 nm, 610 nm, 600 nm, 590 nm, 580 nm, 570 nm, 560 nm, 550 nm, 540 nm, 530 nm, 520 nm, 510 nm, or 500 nm, or may be less than one lower limit selected from the above numerical group. The size of the nanowire is not particularly limited, and may be any size between the above upper and lower limits. In the device of the present disclosure, the use of nanowires can increase the surface area, thereby increasing the EV collection capacity. The length of the nanowire is not particularly limited, and may be any length between two values ​​selected from, for example, 500 nm, 600 nm, 700 nm, 800 nm, 900 nm, 1 μm, 2 μm, 3 μm, 4 μm, 5 μm, 6 μm, 7 μm, 8 μm, 9 μm, and 10 μm. The length and diameter of the nanowire may affect the physical strength and surface area of ​​the nanowire. The length and diameter may be adjusted to suit the environment in which it is used. In one embodiment, the nanowires are 1 μm to 10 μm long {eg, 1.5 μm to 5 μm} and made of a metal oxide {eg, zinc oxide}.

[0019] As used herein, "free," when used in combination with the component listed immediately before the term, means substantially free of or free from that component, where "substantially free" does not exclude the inclusion of non-removable levels of that component in the extract.

[0020] The present inventors have found that by contacting a subject's urine with nanowires having a positively charged surface (e.g., a zinc oxide (ZnO) surface) in a pH range of 6 to 8, extracellular vesicles (EVs) (and free miRNA) in urine are efficiently adsorbed to the nanowires without being destroyed. The present inventors have also found that the EVs and miRNA adsorbed to the nanowires can be effectively recovered using a surfactant.

[0021] The present disclosure provides a urine extract containing any one or more microRNAs listed in Data S1 (or Table 3). The present disclosure provides a urine extract containing all of the microRNAs listed in Data S1 (or Table 3). The present disclosure provides a urine extract containing any one or more microRNAs listed in Table 2. The present disclosure provides a urine extract containing all of the microRNAs listed in Table 2. In certain embodiments of the present disclosure, a urine extract containing any one or more or all of the microRNAs listed in Data S1 (or Table 3) may contain 500 or more, 600 or more, 700 or more, 800 or more, 900 or more, 1000 or more, or 1100 or more microRNAs (particularly microRNAs present in urine). In certain embodiments, a urine extract containing any one or more or all of the microRNAs listed in Data S1 (or Table 3) may contain 749 or more, 822 or more, or 1111 or more microRNAs (particularly microRNAs present in urine). In certain aspects of the present disclosure, urine may contain 500 or more, 600 or more, 700 or more, 800 or more, 900 or more, 1000 or more, or 1100 or more types of microRNAs. In some embodiments, the number of types of microRNAs contained in urine may be the actual number of types of microRNAs contained therein. In some embodiments, the number of types of microRNAs contained in urine may be defined by a microRNA detection method or detection technology. For example, the number of types of microRNAs contained in urine may depend on the detection limit of the microRNA detection method. In certain aspects of the present disclosure, urine may preferably be prepared from urine using the nanowire-incorporated device of the present disclosure. In certain embodiments of the present disclosure, the microRNAs may comprise at least one or all of the microRNAs selected from the group consisting of microRNAs exhibiting the following numerical values ​​(log2 transformed after subtracting background intensity) listed in Data S1 (or Table 3): 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 6 or more, 7 or more, 8 or more, 9 or more, 10 or more, 11 or more, 12 or more, 13 or more, 14 or more, 15 or more, and 16 or more. In certain embodiments of the present disclosure, the microRNAs may comprise at least one or all of the microRNAs selected from the group consisting of microRNAs exhibiting the following numerical values ​​(log2 transformed after subtracting background intensity) listed in Data S1 (or Table 3): 1 or more but less than 2, 2 or more but less than 3, 3 or more but less than 4, 4 or more but less than 5, 5 or more but less than 6, 6 or more but less than 7, 7 or more but less than 8, 8 or more but less than 9, 9 or more but less than 10, 10 or more but less than 11, 11 or more but less than 12, 12 or more but less than 13, 13 or more but less than 14, 14 or more but less than 15, and 16 or more. In this embodiment, the value may be the value in a non-cancer donor (e.g., a healthy individual), the value in a lung cancer patient, the value in a pancreatic cancer patient, the value in a liver cancer patient, the value in a bladder cancer patient, the value in a prostate cancer patient, the value in a stomach cancer patient, the value in a urothelial cancer patient, the value in a melanoma patient, the value in an ovarian cancer patient, the value in a thyroid cancer patient, the value in a cervical cancer patient, the value in a colorectal cancer patient, and / or the value in an endometrial cancer patient. In this embodiment, the value may be, for example, the value in a digestive cancer patient, the value in a hematopoietic cancer patient, and / or the value in a urinary cancer patient. In this embodiment, the value may be the value in all cancer patients.

[0022] According to the present disclosure, miR-3117-5p, miR-3118, miR-3121-3p, miR-3121-5p, miR-3126-5p, miR-3128, miR-3133, miR- 3134, miR-3136-3p, miR-3136-5p, miR-3139, miR-3142, miR-3143, miR-3145-3p, miR-3163, miR-3166, m iR-3167, miR-16-1-3p, miR-424-3p, miR-519c-5p, miR-525-5p, miR-551b-5p, miR-558, miR-921, miR-9 42-3p, miR-3126-3p, miR-3127-5p, miR-3129-5p, miR-3144-5p, miR-3150a-5p, miR-3152-5p, miR-3155a , miR-3157-3p, miR-3159, miR-3165, miR-3678-3p, miR-4321, miR-4521, miR-4800-3p, miR-4999-5p, mi R-5096, miR-5187-5p, miR-6874-5p, miR-3127-3p, miR-3130-5p, miR-3131, miR-3141, miR-3150b-5p, m A urine extract is provided, comprising at least one or all of the microRNAs selected from the group consisting of miR-3151-3p, miR-3151-5p, miR-3154, miR-3160-3p, miR-3160-5p, miR-378a-5p, miR-520c-3p, miR-526b-3p, miR-3150a-3p, miR-3162-5p, and miR-4254. According to the present disclosure, a urine extract is provided, comprising at least one or all of the microRNAs selected from the group consisting of miR-3163, miR-16-1-3p, miR-424-3p, miR-558, miR-3127-5p, and miR-4521. According to the present disclosure, there is provided a urine extract containing at least one microRNA selected from the group consisting of miR-378a-5p, miR-520c-3p, and miR-526b-3p, or all of the microRNAs. These microRNAs can be detected in the urine of lung cancer patients. Thus, according to the present disclosure, the urine can be urine from a subject with lung cancer.

[0023] According to the present disclosure, let-7i-3p, miR-183-5p, miR-202-5p, miR-409-5p, miR-4661-5p, miR-4800-3p, miR-5587-5p, miR-372-3p, miR-378b, miR-520b, miR-1266-3p, miR-3605-5p, miR-3612, miR-4645-3p, miR-4694-3p, miR-4752, miR-6816-3p, miR-8087, let-7f-2-3p, miR-15a-3p, miR-20a-3p, miR-33b-3p, miR-34c-5p, miR-93-5p, miR-130a-5p, miR-135a-5p, miR-135b-5p, miR-185-5p, miR-203a-3p, miR-302d-5p, miR-337-3p, miR-378c, miR-422a, miR-449c-5p, miR-483-5p, miR-506-3p, miR-511-5p, miR-520c-3p, miR-654-3p, miR-668-5p, miR-670-5p, miR-671-3p, miR-744-3p, miR-1178-3p, miR-1254, miR-1284, miR-1323, miR-2116-5p, miR-2355-3p, miR-3132, miR-3138, miR-3164, miR-3186-3p, miR-3189-3p, miR-3198, miR-3200-5p, miR-3657, miR-3667-5p, miR-3680-5p, miR-3692-5p, miR-3713, miR-3921, miR-3936, miR-4273, miR-4299, miR-4306, miR-4316, miR-4319, miR-4421, miR-4429, miR-4435, miR-4441, miR-4473, miR-4506, miR-4633-5p, miR-4658, miR-4733-5p, miR-4733-3p, miR-5004-3p, miR-5194, miR-5197-5p, miR-5571-5p, miR-6083, miR-6717-5p, miR-6720-5p, miR-6767-3p, miR-6781-3p, miR-6811-3p, miR-6821-3p, miR-6828-5p, miR-6832-5p, miR-6837-3p,A urine extract is provided, comprising at least one or all of the microRNAs selected from the group consisting of miR-6841-5p, miR-6853-5p, miR-6871-3p, miR-6875-5p, miR-6878-5p, miR-7112-3p, miR-7703, miR-7848-3p, and miR-7856-5p. According to the present disclosure, a urine extract is provided, comprising at least one or all of the microRNAs selected from the group consisting of miR-183-5p, miR-202-5p, and miR-409-5p. According to the present disclosure, a urine extract is provided containing at least one or all of the microRNAs selected from the group consisting of miR-372-3p, miR-520b, miR-15a-3p, miR-34c-5p, miR-135a-5p, miR-185-5p, miR-337-3p, miR-422a, miR-506-3p, miR-520c-3p, miR-1284, miR-1323, and miR-4273. These microRNAs can be detected in the urine of patients with pancreatic cancer. Thus, according to the present disclosure, the urine can be urine from a subject with pancreatic cancer.

[0024] According to the present disclosure, miR-4521, let-7c-3p, let-7i-5p, miR-16-1-3p, miR-26a-1-3p, miR-28-5p, miR-105-5p, miR-195-3p, miR-200b-5p, miR-219a-2-3p , miR-297, miR-300, miR-330-3p, miR-374b-5p, miR-431-5p, miR-454-5p, miR-513c-5p, miR-548ax, miR-593-5p, miR-623, miR-664a-5p, miR-9 The present invention provides an extract of urine comprising at least one or all microRNAs selected from the group consisting of miR-42-3p, miR-1205, miR-1276, miR-1288-3p, miR-1297, miR-3678-3p, miR-4283, miR-4295, miR-4439, miR-4524b-5p, miR-4703-3p, miR-4768-5p, miR-4800-3p, miR-5187-5p, miR-5696, miR-7161-5p, let-7i-2-3p, and miR-520c-3p. According to the present disclosure, a urine extract is provided containing at least one or all of the microRNAs selected from the group consisting of miR-16-1-3p, miR-28-5p, miR-297, miR-300, miR-330-3p, miR-454-5p, miR-1297, and miR-4295. According to the present disclosure, a urine extract is provided containing miR-520c-3p. These microRNAs can be detected in the urine of subjects with liver cancer. Thus, the urine may be from a subject with liver cancer.

[0025] According to the present disclosure, miR-16-1-3p, miR-23b-3p, miR-28-5p, miR-92a-2-5p, miR-142-3p, miR-195-3p, miR-1 96b-5p, miR-299-3p, miR-492, miR-513b-5p, miR-601, miR-619-5p, miR-1285-3p, miR-3155a, miR The present disclosure provides a urine extract containing at least one or all of the microRNAs selected from the group consisting of miR-3162-5p, miR-3678-3p, miR-4283, miR-4295, miR-4311, miR-4531, miR-5096, miR-5187-5p, let-7f-2-3p, miR-520c-3p, and miR-4783-5p. The present disclosure provides a urine extract containing at least one or all of the microRNAs selected from the group consisting of miR-16-1-3p, miR-23b-3p, miR-28-5p, miR-142-3p, miR-195-3p, miR-299-3p, and miR-4295. The present disclosure provides a urine extract containing miR-520c-3p. These microRNAs can be detected in embodiments with bladder cancer. Thus, in the present disclosure, the urine can be urine from a subject with bladder cancer.

[0026] According to the present disclosure, miR-4531, miR-28-5p, miR-103a-2-5p, miR-105-5p, miR-124-3p, miR-151a-5p, miR-151b, miR-200a-5p, mi R-300, miR-424-3p, miR-519c-5p, miR-551b-5p, miR-617, miR-873-3p, miR-921, miR-1288-3p, miR-3124-5p, miR-31 The present disclosure provides a urine extract containing at least one or all of the microRNAs selected from the group consisting of miR-55a, miR-3917, miR-4283, miR-4727-3p, miR-5096, miR-5187-5p, miR-6074, miR-6874-5p, miR-6892-5p, miR-15a-3p, miR-135b-5p, miR-520c-3p, miR-4783-5p, and miR-7849-3p. The present disclosure also provides a urine extract containing at least one or all of the microRNAs selected from the group consisting of miR-28-5p, miR-105-5p, miR-124-3p, miR-151a-5p, and miR-300. According to the present disclosure, a urine extract is provided, which contains at least one or all of the microRNAs selected from the group consisting of miR-15a-3p and miR-520c-3p. These microRNAs can be detected in subjects with prostate cancer. Thus, in the present disclosure, the urine can be urine from a subject with prostate cancer.

[0027] Another aspect of the present disclosure provides a method for testing the possibility that a subject has cancer. The method for testing the possibility of cancer can be interpreted as a method for diagnosing cancer, a method for obtaining preliminary information for diagnosing cancer, a method for determining whether cancer cells are present in a subject's body, a method for detecting cancer cells, a method for predicting the possibility of cancer, or a method for assessing the possibility that a subject has cancer, and these methods can be used interchangeably. In the present disclosure, if a subject is determined to have cancer by a method for testing the possibility of cancer, a definitive diagnosis can then be made by a physician or other professional. The present disclosure provides a method that includes diagnosing cancer and administering anti-cancer treatment (e.g., radiation therapy, chemotherapy, immunotherapy, and / or surgery) to a patient diagnosed with cancer.

[0028] In the present disclosure, the possibility that a subject has cancer can be determined using the expression level of any of the microRNAs listed in Data S1 (or Table 3) in a body fluid sample as an indicator.

[0029] According to the present disclosure, a urine extract is provided that contains one or more microRNAs listed in any one of Tables 4-1 to 4-15. According to the present disclosure, a urine extract is provided that contains all of the microRNAs listed in any one of Tables 4-1 to 4-15. According to the present disclosure, a urine extract is provided that contains one or more microRNAs listed in any one of Tables 4-1 to 4-15. According to the present disclosure, a urine extract is provided that contains all of the microRNAs listed in any one of Tables 4-1 to 4-15. Here, the microRNA may be a microRNA that is increased in cancer patients. Thus, in certain aspects, detection of a microRNA in a urine extract may indicate that the subject from which the urine was derived has cancer or is likely to have cancer. The present disclosure provides a method for analyzing urine, the method comprising obtaining a urine extract. The method for analyzing urine of the present disclosure may further comprise extracting microRNA from the urine extract. The method for analyzing urine of the present disclosure may determine whether a specific microRNA is contained in the urine extract. The method for analyzing urine of the present disclosure may further comprise measuring the abundance of the microRNA if the specific microRNA is contained in the extracted microRNA. In the method for analyzing urine of the present disclosure, the specific microRNA may be any one or more microRNAs listed in any one of Tables 4-1 to 4-15. In the method for analyzing urine of the present disclosure, the specific microRNA may be any one or more microRNAs listed in any one of Tables 4-1 to 4-15, and may have a p-value of less than 0.005. In the method for analyzing urine of the present disclosure, the specific microRNA may be any one or more microRNAs listed in any one of Tables 22-1 to 22-13. The specific microRNA may be any one or more microRNAs listed in any one of Tables 22-1 to 22-13 with an accuracy of more than 50%, 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, or 95% or more. The specific microRNA may be any one or more microRNAs listed in any one of Tables 22-1 and 23-1 to 23-14, and preferably a microRNA with an accuracy of more than 50%, 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, or 95% or more. The specific microRNA may be any one or more microRNAs listed in any one of Tables 24-1 to 24-15, and may be a microRNA that exhibits an accuracy of greater than 0.5, 0.55 or greater, 0.6 or greater, 0.65 or greater, 0.7 or greater, 0.75 or greater, 0.8 or greater, 0.85 or greater, or 0.9 or greater. The specific microRNA may be any one or more microRNAs listed in any one of Tables 25-1 to 25-15, and may be a microRNA that exhibits an accuracy of greater than 0.5, 0.55 or greater, 0.6 or greater, 0.65 or greater, 0.7 or greater, 0.75 or greater, 0.8 or greater, 0.85 or greater, or 0.9 or greater.The specific microRNAs may include 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500 or more, 600 or more, 700 or more, 800 or more, 900 or more, 1000 or more, 1100 or more, 1200 or more, 1300 or more, 1400 or more, 1500 or more, 1600 or more, 1700 or more, 1800 or more, 1900 or more, 2000 or more, 2100 or more, 2200 or more, 2300 or more, 2400 or more, or 2500 or more microRNAs. The specific microRNAs can be detected or the amount thereof can be measured by various known methods. A specific microRNA can be identified by contacting it with a nucleic acid comprising a sequence capable of hybridizing to the microRNA. The nucleic acid comprising a sequence capable of hybridizing to the microRNA can be immobilized. The nucleic acid comprising a sequence capable of hybridizing to the microRNA may be immobilized on a microarray. The nucleic acid comprising a sequence capable of hybridizing to the microRNA may be a probe for RT-PCR. In one embodiment of the present disclosure, a urine extract containing any one or more or all of the microRNAs listed in any of Tables 4-1 to 4-15 contains 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500 or more, 600 or more types of microRNAs (particularly microRNAs present in urine). In some embodiments of the present disclosure, a urine extract containing one or more or all of the microRNAs listed in any one of Tables 4-1 to 4-15 may contain more than 50%, 60% or more, 700% or more, 800% or more, 900% or more, 1000 or more, 1100 or more, 1200 or more, 1300 or more, 1400 or more, 1500 or more, 1600 or more, 1700 or more, 1800 or more, 1900 or more, 2000 or more, 2100 or more, 2200 or more, 2300 or more, 2400 or more, or 2500 or more microRNAs. In some embodiments of the present disclosure, a urine extract containing one or more or all of the microRNAs listed in any one of Tables 4-1 to 4-15 may contain more than 50%, 60% or more, 70% or more, 80% or more, 90% or more, or all of the microRNAs listed in each table. In some embodiments, a urine extract containing any one or more or all of the microRNAs listed in Table 1 may contain 749 or more, 822 or more, or 1111 or more microRNAs (particularly microRNAs present in urine). Here, the microRNAs may be microRNAs that are elevated in cancer patients. Thus, in some embodiments, detection of microRNAs in a urine extract may indicate that the subject from which the urine was obtained has or is likely to have cancer. In certain aspects of the present disclosure, a urine extract containing any one or more or all of the microRNAs listed in any of Tables 4-1 through 4-15 may contain 500 or more, 600 or more, 700 or more, 800 or more, 900 or more, 1000 or more, 1100 or more, 1200 or more, 1300 or more, 1400 or more, 1500 or more, 1600 or more, 1700 or more, 1800 or more, 1900 or more, 2000 or more, 2100 or more, 2200 or more, 2300 or more, 2400 or more, or 2500 or more microRNAs present in urine. In some embodiments, the number of microRNA species present in urine may be the actual number of microRNA species present. In some embodiments, the number of microRNA species present in urine may be determined by a microRNA detection method or technique. For example, the number of types of microRNA contained in urine may depend on the detection limit of the microRNA detection method. In some embodiments of the present disclosure, the microRNA may be preferably prepared from urine using the nanowire-incorporated device of the present disclosure. In certain aspects of the present disclosure, the microRNAs may include at least one or all of the microRNAs selected from the group consisting of microRNAs listed in Table 4-1 that exhibit a sensitivity and / or specificity of greater than 50%, greater than 55%, greater than 60%, greater than 65%, greater than 70%, greater than 75%, greater than 80%, greater than 85%, greater than 90%, or greater than 95% based on the sensitivity and / or specificity values ​​listed in Table 4-1. In certain embodiments of the present disclosure, the microRNAs may include at least one or all of the microRNAs listed in Table 4-1, which exhibit sensitivity and / or specificity values ​​listed in Table 4-1 of greater than 50% but less than 55%, greater than 55% but less than 60%, greater than 60% but less than 65%, greater than 65% but less than 70%, greater than 70% but less than 75%, greater than 75% but less than 80%, greater than 80% but less than 85%, greater than 85% but less than 90%, greater than 90% but less than 95%, or greater than 95%. Here, the microRNA may be a microRNA that is elevated in cancer patients. Thus, in certain embodiments, detection of a microRNA in a urine extract may indicate that the subject from which the urine was obtained has or is likely to have cancer. Whether the expression level of a particular microRNA is increased or decreased in a particular cancer compared to healthy individuals can be confirmed by checking whether the expression level of the particular microRNA is increased or decreased in a particular cancer compared to healthy individuals in Tables 4-1 to 4-15. In the present invention, the microRNA contained in the urine extract is detectable by microarray, or in sufficient amounts to do so.

[0030] According to the present disclosure, hsa-let-7a-3p, hsa-miR-103a-2-5p, hsa-miR-103a-3p, hsa-miR-105-3p, hsa-miR-106a-3p, hsa-miR-1180-3p, hsa-miR-1185-2-3p, hsa-miR-1193, hsa-miR-127-3p, hsa-miR-1245b-5p, hsa-miR-1247-3p, hsa-miR-125b-2-3p, hsa-miR-1263, hsa-miR-173g-3p, hsa-miR-129-2-3p, hsa-miR-1293, hsa-miR-1301-5p, hsa-miR-130a-3p, hsa-miR-!30a-5p, hsa-miR-1469, hsa-miR-149-5p, hsa-miR-152-5p, hsa-miR-15b-3p, hsa-miR-16-1-3p, hsa-miR-181a-3p, hsa-miR-184, hsa-miR-186-5p, hsa-miR-18a-5p, hsa-miR-193b-3p, hsa-miR-200a-3p, hsa-miR-200c-5p, hsa-miR-208b-5p, hsa-miR-216a-3p, hsa-miR-7b-5p, hsa-miR-2861, hsa-miR-2909, hsa-miR-298, hsa-miR-29a-5p, hsa-miR-302b-3p, hsa-miR-30b-3p, hsa-miR-30d-5p, hsa-miR-3116, hsa-miR-3122, hsa-miR-3125, hsa-miR-3126-3p, hsa-miR-3129-3p, hsa-miR-3130-3p, hsa-miR-3133, hsa-miR-3136-3p, hsa-miR-3137, hsa-miR-3143, hsa-miR-3150a-3p, hsa-miR-3174, hsa-miR-3177-5p, hsa-miR-3179, hsa-miR-318!0, hsa-miR-3186-3p, hsa-miR-3186-5p, hsa-miR-3187-3p, hsa-miR-3189-3p, hsa-miR-3190-3p, hsa-miR-3190-5p, hsa-miR-3194-5p, hsa-miR-3195, hsa-miR-3197, hsa-miR-3198, It should be noted that there seems to be a typo in the original text where "hsa-miR-!30a-5p" and "hsa-miR-318!0" are incorrect notations. The above translation is based on the text as provided with these potential errors.hsa-miR-3200-5p、hsa-miR-320a、hsa-miR-320c、hsa-miR-320d、hsa-miR-323b-5p、hsa-miR-324-3p、hsa-miR-325、hsa-miR-32-5p、hsa-miR-329- 3p、hsa-miR-331-3p、hsa-miR-331-5p、hsa-miR-335-3p、hsa-miR-337-3p、hsa-miR-337-5p、hsa-miR-33a-3p、hsa-miR-33a-5p、hsa-miR-342-3p、h sa-miR-345-5p、hsa-miR-346、hsa-miR-34a-5p、hsa-miR-3606-3p、hsa-miR-3607-5p、hsa-miR-3613-3p、hsa-miR-3613-5p、hsa-miR-361-3p、hsa- miR-3616-3p, hsa-miR-3616-5p, hsa-miR-3621, hsa-miR-3622a-5p, hsa-miR-363-3p, hsa-miR-3658, hsa-miR-3659, hsa-miR-367-3p, hsa-miR-367 4、hsa-miR-3678-3p、hsa-miR-3681-5p、hsa-miR-3683、hsa-miR-3684、hsa-miR-3690、hsa-miR-374c-5p、hsa-miR-376a-3p、hsa-miR-376a-5p、hsa -miR-376b-3p、hsa-miR-384、hsa-miR-3913-3p、hsa-miR-3940-3p、hsa-miR-3960、hsa-miR-3976、hsa-miR-4269、hsa-miR-477、hsa-miR-4302、hsa -miR-4303、hsa-miR-4304、hsa-miR-4307、hsa-miR-4316、hsa-miR-4319、hsa-miR-432-3p、hsa-miR-432-5p、hsa-miR-4326、hsa-miR-4421、hsa-mi R-4433b-5p、hsa-miR-4456、hsa-miR-4472、hsa-miR-4479、hsa-miR-4521、hsa-miR-4639-5p、hsa-miR-4646-5p、hsa-miR-4660、hsa-miR-4662a-3p、hsa-miR-4688, hsa-miR-4694-3p, hsa-miR-4695-3p, hsa-miR-4695-5p, hsa-miR-4699-3p, hsa-miR-4701-5p, hsa-miR-4704-3p, hsa-miR-4716-5 p、hsa-miR-4719、hsa-miR-4721、hsa-miR-4724-5p、hsa-miR-4736、hsa-miR-4738-3p、hsa-miR-4740-3p、hsa-miR-4750-5p、hsa-miR-4753-5p、hsa -miR-4759、hsa-miR-4776-5p、hsa-miR-4778-3p、hsa-miR-4793-5p、hsa-miR-4796-5p、hsa-miR-4799-3p、hsa-miR-4804-5p、hsa-miR-487b-5p、hs a-miR-497-5p, hsa-miR-5008-3p, hsa-miR-5011-5p, hsa-miR-509-5p, hsa-miR-514a-3p, hsa-miR-514b-5p, hsa-miR-515-3p, hsa-miR-518f-3p, h sa-miR-5194, hsa-miR-525-3p, hsa-miR-541-3p, hsa-miR-548aa, hsa-miR-548t-3p, hsa-miR-548ae-3p, hsa-miR-548c-3p, hsa-miR-548c-5p, hsa-miR-548o-5p, hsa-miR-548am-5p, hsa-miR-548f-5p, hsa-miR-548j-3p, hsa-miR-548n, hsa-miR-548v, hsa-miR-548x-3p, hsa-miR-548z, hsa-miR -548h-3p、hsa-miR-549a、hsa-miR-5571-5p、hsa-miR-5572、hsa-miR-5580-5p、hsa-miR-5586-3p、hsa-miR-5586-5p、hsa-miR-561-3p、hsa-miR-57 1, hsa-miR-574-3p, hsa-miR-578, hsa-miR-582-3p, hsa-miR-593-5p, hsa-miR-598-3p, hsa-miR-601, hsa-miR-606, hsa-miR-6068, hsa-miR-6077hsa-miR-6083, hsa-miR-6089, hsa-miR-6090, hsa-miR-6132, hsa-miR-6133, hsa-miR-616-5p, hsa-miR-617, hs a-miR-620, hsa-miR-622, hsa-miR-623, hsa-miR-625-5p, hsa-miR-626, hsa-miR-636, hsa-miR-642b-5p, hsa-m iR-649, hsa-miR-6504-5p, hsa-miR-6508-3p, hsa-miR-6511b-3p, hsa-miR-6513-5p, hsa-miR-651-5p, hsa-miR -6516-5p, hsa-miR-652-3p, hsa-miR-661, hsa-miR-664a-3p, hsa-miR-664a-5p, hsa-miR-665, hsa-miR-671-3p , hsa-miR-6715b-3p, hsa-miR-6720-5p, hsa-miR-6721-5p, hsa-miR-6726-3p, hsa-miR-6734-3p, hsa-miR-6735 -5p, hsa-miR-6742-3p, hsa-miR-6755-3p, hsa-miR-6760-3p, hsa-miR-6767-5p, hsa-miR-6777-5p, hsa-miR-67 The present invention provides a urine extract comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of miR-82-5p, miR-6890-3p, miR-8084, miR-888-3p, miR-92b-5p, miR-935, miR-93-5p, and miR-942-3p.

[0031] According to the present disclosure, hsa-miR-103a-3p, hsa-miR-1193, hsa-miR-127-3p, hsa-miR-1247-3p, hsa-miR-1263, hsa-miR-173g-3p, hsa-miR-129-2-3p, hsa-miR-1293, hsa-miR-130a-5p, hsa-miR-1469, hsa-miR-15b-3p, hsa-miR-193b-3p, hsa-miR-2861, hsa-miR-298, hsa-miR-30d-5p, hsa-miR-3122, hsa-miR-3137, hsa-miR-3174, hsa-miR-3177-5p, hsa-miR-3186-3p, hsa-miR-3187-3p, hsa-miR-3189-3p, hsa-miR-3190-5p, hsa-miR-3194-5p, hsa-miR-3198, hsa-miR-320c, hsa-miR-329-3p, hsa-miR-337-3p, hsa-miR-337-5p, hsa-miR-33a-3p, hsa-miR-345-5p, hsa-miR-346, hsa-miR-34a-5p, hsa-miR-3613-3p, hsa-miR-361-3p, hsa-miR-3616-3p, hsa-miR-3622a-5p, hsa-miR-363-3p, hsa-miR-3659, hsa-miR-3678-3p, hsa-miR-3681-5p, hsa-miR-374c-5p, hsa-miR-3960, hsa-miR-3976, hsa-miR-4269, hsa-miR-4304, hsa-miR-4307, hsa-miR-432-3p, hsa-miR-4433b-5p, hsa-miR-4456, hsa-miR-4472, hsa-miR-4479, hsa-miR-4521, hsa-miR-4646-5p, hsa-miR-4694-3p, hsa-miR-4699-3p, hsa-miR-4701-5p, hsa-miR-4hsa-miR-5580-5p, hsa-miR-574-3p, hsa-miR-578, hsa-miR-582-3p, hsa-miR-598-3p, hsa-miR-6068, hsa-miR-6077, hsa-miR-6089, hsa -miR-6133, hsa-miR-616-5p, hsa-miR-622, hsa-miR-626, hsa-miR-636, hsa-miR-6504-5p, hsa-miR-6516-5p, hsa-miR-661, hsa-miR-66 The present invention provides a urine extract comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of miR-6715b-3p, miR-6720-5p, miR-6734-3p, miR-6742-3p, miR-6760-3p, miR-6767-5p, miR-6777-5p, miR-6890-3p, and miR-93-5p.

[0032] According to the present disclosure, hsa-miR-103a-2-5p, hsa-miR-1193, hsa-miR-3622a-5p, hsa-miR-363-3p, hsa-miR-4521, hsa-miR-4796-5p, hsa-miR-518f-3p, hsa-miR-5580-5p, hsa-miR-3125, hsa-miR-3130-3p, hsa-miR-3678-3p, hsa-miR-4750-5p, hsa-miR-5194, hsa-miR-578, hsa-miR-625-5p, hsa-miR-6755-3p, hsa-miR-1293, hsa-miR-3137, hsa-miR-4646-5p, hsa-miR-514b-5p, hsa-miR-598-3p, hsa-miR-200c-5p, hsa-miR-3150a-3p, hsa-miR-3186-3p, hsa-miR-3187-3p, hsa-miR-3189-3p, hsa-miR-4303, hsa-miR-320a, hsa-miR-4421, hsa-miR-515-3p, hsa-miR-665, hsa-miR-6767-5p, hsa-miR-6782-5p, hsa-miR-3659, hsa-miR-3690, hsa-miR-4721, hsa-miR-4776-5p, hsa-miR-622, hsa-miR-2909, hsa-miR-3200-5p, hsa-miR-323b-5p, hsa-miR-34a-5p, hsa-miR-4688, hsa-miR-3190-3p, hsa-miR-3613-3p, hsa-miR-4793-5p, hsa-miR-6083, hsa-miR-4316, hsa-miR-4738-3p, hsa-miR-5572, hsa-miR-hsa-miR-4740-3p, hsa-miR-103a-3p, hsa-miR-181a-3p, hsa-miR-337-5p, hsa-miR-1263, hsa-miR-374c-5p, hsa-miR-1180-3p, hsa -miR-29a-5p, hsa-miR-509-5p, hsa-miR-15b-3p, hsa-miR-32-5p, hsa-miR-376a-3p, hsa-miR-4804-5p, hsa-miR-5011-5p, hsa-miR -582-3p, hsa-miR-320d, hsa-miR-130a-3p, hsa-miR-200a-3p, hsa-miR-4639-5p, hsa-miR-571, hsa-miR-33a-5p, hsa-miR-4719, hs a-miR-3681-5p, hsa-miR-4699-3p, hsa-miR-626, hsa-miR-105-3p, hsa-miR-384, hsa-miR-3976, hsa-miR-186-5p, hsa-miR-18a-5p , hsa-miR-3616-5p, hsa-miR-4302, hsa-miR-548c-5p, hsa-miR-548o-5p, hsa-miR-548am-5p, hsa-miR-548v, hsa-let-7a-3p, hsa-m iR-3143, hsa-miR-367-3p, hsa-miR-376a-5p, hsa-miR-548ae-3p, hsa-miR-5586-5p, hsa-miR-6715b-3p, hsa-miR-548aa, hsa-miR- The present invention provides a urine extract comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of miR-548t-3p, miR-652-3p, miR-3607-5p, miR-3683, miR-477, miR-4704-3p, miR-4799-3p, miR-548x-3p, miR-549a, and miR-6508-3p.

[0033] According to the present disclosure, hsa-miR-103a-2-5p, hsa-miR-106a-3p, hsa-miR-1185-2-3p, hsa-miR-1193, hsa-miR-1273g-3p, hsa-miR-1293, hsa-miR-1301-5p, hsa-miR-152-5p, hsa-miR-184, hsa-miR-200c-5p, hsa-miR-2909, hsa-miR-298, hsa-miR-302b-3p, hsa-miR-3116, hsa-miR-3122, hsa-miR-3125, hsa-miR-3126-3p, hsa-miR-3129-3p, hsa-miR-3130-3p, hsa-miR-3133, hsa-miR-3137, hsa-miR-3150a-3p, hsa-miR-3174, hsa-miR-3177-5p, hsa-miR-3179, hsa-miR-3186-3p, hsa-miR-3186-5p, hsa-miR-3187-3p, hsa-miR-3189-3p, hsa-miR-3190-3p, hsa-miR-3200-5p, hsa-miR-320a, hsa-miR-320c, hsa-miR-323b-5p, hsa-miR-325, hsa-miR-331-5p, hsa-miR-335-3p, hsa-miR-33a-3p, hsa-miR-342-3p, hsa-miR-34a-5p, hsa-miR-3606-3p, hsa-miR-3616-3p, hsa-miR-3621, hsa-miR-3622a-5p, hsa-miR-3659, hsa-miR-3690, hsa-miR-376b-3p, hsa-miR-3913-3p, hsa-miR-4269, hsa-miR-4303, hsa-miR-4304, hsa-miR-4307, hsa-miR-4316, hsa-miR-4326, hsa-miR-4421, hsa-miR-4472, hsa-miR-4479, hsa-miR-4646-5p, hsa-miR-4660, hsa-miR-4688, hsa-miR-4695-3p, hsa-miR-4695-5p, hsa-miR-4721, hsa-miR-4724-5p, hsa-miR-4738-3p, hsa-miR-4740-3p, hsa-miR-4750-5p,hsa-miR-4753-5p,hsa-miR-4759,hsa-miR-4776-5p,hsa-miR-4778-3p,hsa-miR-4796-5p,hsa-miR- 487b-5p,hsa-miR-5008-3p,hsa-miR-514b-5p,hsa-miR-518f-3p,hsa-miR-5194,hsa-miR-541-3p,h sa-miR-548c-3p,hsa-miR-548j-3p,hsa-miR-548n,hsa-miR-548z,hsa-miR-548h-3p,hsa-miR-5572 ,hsa-miR-5580-5p,hsa-miR-5586-3p,hsa-miR-601,hsa-miR-6068,hsa-miR-6083,hsa-miR-6133,hs a-miR-617,hsa-miR-622,hsa-miR-625-5p,hsa-miR-649,hsa-miR-6504-5p,hsa-miR-6513-5p,hsa- miR-651-5p,hsa-miR-6516-5p,hsa-miR-661,hsa-miR-664a-5p,hsa-miR-665,hsa-miR-6755-3p,hs A urine extract is provided, comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of a-miR-6767-5p, hsa-miR-6777-5p, hsa-miR-6782-5p, hsa-miR-8084, hsa-miR-888-3p, and hsa-miR-942-3p. In this embodiment, the urine extract may be a urine extract from a patient with stage I cancer. In a specific embodiment, the patient with stage I cancer may be a patient with stage I lung cancer. These miRNAs are detected in higher concentrations in the urine of stage I lung cancer patients than healthy individuals. The stage may be determined, for example, according to the TNM classification. In the TNM classification, stage determination is based on three aspects: T: size of the cancer, N: presence or absence of metastasis to lymph nodes, and M: metastasis to other organs. Doctors can classify cancer according to the TNM classification. In this specification, early cancer refers to cancer selected from the group consisting of stage I and II cancers.

[0034] In another aspect of the present disclosure, there is provided an extract of urine comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the microRNAs listed in Table 4-2. The present disclosure also provides hsa-miR-492, hsa-miR-1292-5p, hsa-miR-6789-5p, hsa-miR-1268b, hsa-miR-3648, hsa-miR-6781-5p, hsa-miR-4745-5p, h sa-miR-4651,hsa-miR-12120,hsa-miR-3937,hsa-miR-1908-5p,hsa-miR-10400-3p,hsa-miR-6125,hsa-miR-504-5p,hsa-miR-6791 -5p,hsa-miR-6743-5p,hsa-miR-4530,hsa-miR-6798-5p,hsa-miR-4458,hsa-miR-1343-5p,hsa-miR-6081,hsa-miR-6724-5p,hsa-m iR-8072,hsa-miR-4763-3p,hsa-miR-320c,hsa-miR-4321,hsa-miR-4673,hsa-miR-92a-2-5p,hsa-miR-184,hsa-miR-1469,hsa-miR -193b-5p,hsa-miR-4497,hsa-miR-4749-5p,hsa-miR-6821-5p,hsa-miR-3124-5p,hsa-miR-106a-3p,hsa-miR-638,hsa-miR-6732-5 p,hsa-miR-92b-5p,hsa-miR-135a-3p,hsa-miR-6845-5p,hsa-miR-1227-5p,hsa-miR-6750-5p,hsa-miR-4707-5p,hsa-miR-20b-3p, hsa-miR-10392-3p,hsa-miR-3141,hsa-miR-4467,hsa-miR-3197,hsa-miR-4285,hsa-miR-4695-5p,hsa-miR-1915-3p,hsa-miR-472 0-5p,hsa-miR-10396b-5p,hsa-miR-4258,hsa-miR-10396a-3p,hsa-miR-4454,hsa-miR-4507,hsa-miR-3162-5p,hsa-miR-6850-5p,hsa-miR-1236-5p,hsa-miR-4632-5p,hsa-miR-7108-5p,hsa-miR-4435,hsa-miR-6768-5p,hsa-miR-25-5p,hsa-miR-769-3p,hsa-miR-6752-5p,hsa-miR-3620-5p,hsa-miR-6787-5p,hsa-miR-6501-5p,hsa-miR-187-5p,hsa-miR-1294,hsa-miR-4505,hsa-miR-3691-5p,hsa-miR-371b-5p,hsa-mi R-6501-3p,hsa-miR-10392-5p,hsa-miR-498-5p,hsa-miR-3180-3p,hsa-miR-937-5p,hsa-miR-885-3p,hsa-miR-1285-3p,hsa-miR-10401-5p,hsa-miR-6729-5p,hsa-miR-3187-3p,hsa-miR-211-3p,hsa-miR-6721-5p,hsa-miR-4460,hsa-miR-1912-3p,hsa-miR-4665-5p,hsa-miR-4785,hsa-miR -4758-5p,hsa-miR-193a-5p,hsa-miR-29b-3p,hsa-miR-138-5p,hsa-miR-9718,hsa-miR-10396a-5p,hsa-miR-1268a,hsa-miR-5100,hsa-miR-554,hsa-miR-4657,hsa-miR-760,hsa-miR-551b-5p,hsa-miR-5588-5p,hsa-miR-4655-5p,hsa-miR-4684-3p,hsa-miR-4506,hsa-miR-6805-5p,hsa-mi R-766-5p,hsa-miR-663a,hsa-miR-1304-5p,hsa-miR-4741,hsa-miR-6515-5p,hsa-miR-5090,hsa-miR-4466,hsa-miR-6076,hsa-miR-6799-5p,hsa-miR-125b-1-3p,hsa-miR-3934-3p,hsa-miR-6820-5p,hsa-miR-3621,hsa-miR-8064,hsa-miR-1587,hsa-miR-4634,hsa-miR-6068,hsa-miR-4508,hsa-miR-4439,hsa-miR-4727-3p,hsa-miR-6075,hsa-miR-7851-3p,hsa-miR-5001-5p,hsa-miR-4443,hsa-miR-4654,hsa-miR-7854-3p,hsa-miR-604,hsa-miR-4449,hsa-miR-12121,hsa-miR-575,hsa-miR-4429,hsa-miR-6871-5p,hsa-miR-1909-3p,hsa-miR-6080,hsa-miR-6126,hsa-miR- 3161,hsa-miR-1303,hsa-miR-650,hsa-miR-6722-3p,hsa-miR-1237-5p,hsa-miR-4512,hsa-miR-4450,hsa-miR-4314,hsa-miR-6071,hsa-miR-6513-5p,hsa-miR-5698,hsa-miR-6790-5p,hsa-miR-598-5p,hsa-miR-4489,hsa-miR-639,hsa-miR-6839-5p,hsa-miR-1225-5p,hsa-miR-6784-5p, hsa-miR-6809-5p,hsa-miR-4750-5p,hsa-miR-4433b-3p,hsa-miR-4479,hsa-miR-3652,hsa-miR-6793-5p,hsa-miR-124-5p,hsa-miR-4688,hsa-miR-6776-5p,hsa-miR-4648,hsa-miR-3195,hsa-miR-6860,hsa-miR-6838-5p,hsa-miR-4486,hsa-miR-12114,hsa-miR-664b-5p,hsa-miR-5703,h sa-miR-4736,hsa-miR-5189-5p,hsa-miR-617,hsa-miR-519a-3p,hsa-miR-4734,hsa-miR-6861-5p,hsa-miR-762,hsa-miR-8078,hsa-miR-744-5p,hsa-miR-6726-5p,hsa-miR-887-3p,hsa-miR-4754,hsa-miR-6132,hsa-miR-4640-5p,hsa-miR-4433a-3p,hsa-miR-323a-3p,hsa-miR-2115-5p,hsa-miR-3622a-5p,hsa-miR-297,hsa-miR-1293,hsa-miR-4289,hsa-miR-10394-3p,hsa-miR-4724-5p,hsa-miR-3178,hsa-miR-8063,hsa-miR-135a-2-3p,hsa-miR-3196,hsa-miR-5010-5p,hsa-miR-1226-5p,hsa-miR-6761-5p,hsa-miR-1281,hsa-miR-147b-3p,hsa-miR-3135b,hsa-miR-677 0-3p,hsa-miR-202-3p,hsa-miR-378h,hsa-miR-6090,hsa-miR-6816-5p,hsa-miR-6747-5p,hsa-miR-516b-3p,hsa-miR-516a-3p,hsa-miR-6737-5p,hsa-miR-7150,hsa-miR-6840-3p,hsa-miR-4276,hsa-miR-6847-5p,hsa-miR-4498,hsa-miR-6875-5p,hsa-miR-4535,hsa-miR-608,hsa-miR-5 72,hsa-miR-3619-5p,hsa-miR-3663-3p,hsa-miR-4538,hsa-miR-4322,hsa-miR-6804-5p,hsa-miR-6855-5p,hsa-miR-548g-3p,hsa-miR-4257,hsa-miR-5006-5p,hsa-miR-7515,hsa-miR-6893-5p,hsa-miR-6879-5p,hsa-miR-3187-5p,hsa-miR-3185,hsa-miR-6823-5p,hsa-miR-12127,hsa-m iR-6756-5p,hsa-miR-4784,hsa-miR-4746-3p,hsa-miR-4730,hsa-miR-647,hsa-miR-6786-5p,hsa-miR-8075,hsa-miR-486-3p,hsa-miR-3919,hsa-miR-3654,hsa-miR-6763-5p,hsa-miR-6782-5p,hsa-miR-6836-5p,hsa-miR-8071,hsa-miR-11399,hsa-miR-4300,hsa-miR-4437,hsa-miR-612,hsa-miR-6868-5p, hsa-miR-6777-5p, hsa-miR-4691-3p, hsa-miR-658, hsa-miR-548q, hsa-miR-614, hsa-miR-8083, hsa-miR-4638-5p, hsa-miR-1538, hsa-miR-4786-5p, hsa-miR-12122, hsa-miR-6762-5p, hsa-miR-6783-5p, hsa-miR-4708-3p, hsa-miR-550b-2-5p, hsa-miR-6074, hsa-miR-3675-5 p,hsa-miR-6514-5p,hsa-miR-4692,hsa-miR-1912-5p,hsa-miR-1269b,hsa-miR-217-3p,hsa-miR-3616-3p,hsa-miR-4533,hsa-miR-516a-5p,hsa-miR-3074-5p,hsa-miR-1471,hsa-miR-197-5p,hsa-miR-4644,hsa-miR-5088-5p,hsa-miR-151a-3p,hsa-miR-8059,hsa-miR-6127,hsa-miR-610,hs a-miR-629-5p,hsa-miR-382-5p,hsa-miR-6131,hsa-miR-4492,hsa-miR-5194,hsa-miR-6089,hsa-miR-4463,hsa-miR-4428,hsa-miR-6836-3p,hsa-miR-6130,hsa-miR-4686,hsa-miR-4451,hsa-miR-4516,hsa-miR-301a-5p,hsa-miR-3130-3p,hsa-miR-3199,hsa-miR-8069,hsa-miR-6829-5p,hs a-miR-328-3p,hsa-miR-7160-5p,hsa-miR-8077,hsa-miR-1286,hsa-miR-4431,hsa-miR-3682-3p,hsa-miR-1193,hsa-miR-5787,hsa-miR-6766-5p,hsa-miR-6842-5p,hsa-miR-6876-5p,hsa-miR-139-3p,hsa-miR-208a-5p,hsa-miR-4743-3p,hsa-miR-6759-5p,hsa-miR-877-5p,hsa-miR-12124,hsa-miR-7151-3p,hsa-miR-1231,hsa-miR-5572,hsa-miR-4674,hsa-miR-370-3p,hsa-miR-3677-3p,hsa-miR-541-3p,hsa-miR-1468-5p,hsa-miR-7112-5p,hsa-miR-12118,hsa, -miR-4725-3p,hsa-miR-4446-3p,hsa-miR-4681,hsa-miR-1203,hsa-miR-378j,hsa-miR-1910-3p,hsa-miR-449b-5p,hsa-miR-6796-5p,hsa-miR-128-1-5p,hsa-miR-5189-3p,hsa-miR-4448,hsa-miR-510-5p,hsa-miR-4481,hsa-miR-9986,hsa-miR-3917,hsa-miR-149-3p,hsa-miR-7110-5p,h sa-miR-4436a,hsa-miR-410-5p,hsa-miR-2467-3p,hsa-miR-4519,hsa-miR-29a-5p,hsa-miR-6070,hsa-miR-504-3p,hsa-miR-509-3-5p,hsa-miR-4315,hsa-miR-4787-5p,hsa-miR-4327,hsa-miR-550a-3-5p,hsa-miR-668-5p,hsa-miR-6751-5p,hsa-miR-4280,hsa-miR-4759,hsa-miR-921,hsa -miR-6869-5p,hsa-miR-3918,hsa-miR-6895-5p,hsa-miR-758-5p,hsa-miR-939-5p,hsa-miR-1249-5p,hsa-miR-6825-5p,hsa-miR-4502,hsa-miR-6800-5p,hsa-miR-3940-5p,hsa-miR-8057,hsa-miR-5699-3p,hsa-miR-7114-5p,hsa-miR-3180,hsa-miR-8070,hsa-miR-3120-3p,hsa-miR-6717- 5p,hsa-miR-4763-5p,hsa-miR-6877-5p,hsa-miR-10398-3p,hsa-miR-4738-3p,hsa-miR-6813-5p,hsa-miR-4712-3p,hsa-miR-5705,hsa-miR-4487,hsa-miR-6849-5p,hsa-miR-761,hsa-miR-2682-5p,hsa-miR-5585-3p,hsa-miR-6894-5p,hsa-miR-489-5p,hsa-miR-4687-5p,hsa-miR-6503-3p,hsa-miR-6083, hsa-miR-4783-3p, hsa-miR-4711-3p, hsa-miR-5685, hsa-miR-7977, hsa-miR-4483, hsa-miR-3605-5p, hsa-miR-3660, hsa-miR-487a-5p, hsa-miR-185-3p, hsa-miR-3150b-3p, hsa-miR-4690-5p, hsa-miR-4447, hsa-miR-7113-5p, hsa-miR-579-3p, hsa-miR-6500-3p, hsa-miR-204 -3p,hsa-miR-4726-3p,hsa-let-7d-3p,hsa-miR-4769-5p,hsa-miR-6509-5p,hsa-miR-2276-3p,hsa-miR-6129,hsa-miR-616-5p,hsa-miR-8089,hsa-miR-3192-5p,hsa-miR-3059-3p,hsa-miR-4440,hsa-miR-3173-3p,hsa-miR-4701-3p,hsa-miR-3122,hsa-miR-325,hsa-miR-6754-3p,hsa-miR- 718,hsa-miR-12119,hsa-miR-3689b-3p,hsa-miR-3689c,hsa-miR-6772-5p,hsa-miR-30b-3p,hsa-miR-6792-5p,hsa-miR-3665,hsa-miR-147a,hsa-miR-6769b-5p,hsa-miR-3148,hsa-miR-200c-5p,hsa-miR-6848-5p,hsa-miR-296-3p,hsa-miR-4526,hsa-miR-7161-5p,hsa-miR-6765-5p,hsa- miR-7107-5p, hsa-miR-542-5p, hsa-miR-122b-3p, hsa-miR-1343-3p, hsa-miR-4521, hsa-miR-564, hsa-miR-4293, hsa-miR-5093, hsa-miR-6832-5p, hsa-miR-7157-3p, hsa-miR-6511b-5p, hsa-miR-6806-5p, hsa-miR-5190, hsa-miR-4800-5p, hsa-miR-6889-5p, hsa-miR-4748, hsa-miR-520c-3p,hsa-miR-6767-5p, hsa-miR-4474-3p, hsa-miR-4294, hsa-miR-6865-3p, hsa-miR-4256, hsa-miR-4743-5p, hsa-miR-3928-3p, hsa-miR-1273c, hsa-miR-585-5p, hsa-miR-4520-3p, hsa-miR-665, hsa-miR-483-5p, hsa-miR-1307-3p, hsa-miR-4317, hsa-miR-5589-5p, hsa-miR-373-3p, hsa-miR-673 8-3p,hsa-miR-4676-5p,hsa-miR-6753-5p,hsa-miR-6740-5p,hsa-miR-3646,hsa-miR-1207-5p,hsa-miR-6870-5p,hsa-miR-7704,hsa-miR-4647,hsa-miR-3666,hsa-miR-4253,hsa-miR-3926,hsa-miR-6722-5p,hsa-miR-3190-3p,hsa-miR-4436b-3p,hsa-miR-3944-5p,hsa-miR-4485-5p,hsa-m iR-1909-5p,hsa-miR-6892-5p,hsa-miR-130a-5p,hsa-miR-8073,hsa-miR-342-3p,hsa-miR-4296,hsa-miR-6845-3p,hsa-miR-103a-3p,hsa-miR-5690,hsa-miR-892b,hsa-miR-4465,hsa-miR-5087,hsa-miR-34c-5p,hsa-miR-1276,hsa-miR-4456,hsa-miR-1224-5p,hsa-miR-6857-5p,hsa-miR- 4261,hsa-miR-6727-5p,hsa-miR-3155a,hsa-miR-4539,hsa-miR-361-5p,hsa-miR-4709-5p,hsa-miR-619-5p,hsa-miR-4513,hsa-miR-6822-5p,hsa-miR-2392,hsa-miR-378g,hsa-miR-3142,hsa-miR-326,hsa-miR-210-3p,hsa-miR-6814-5p,hsa-miR-4260,hsa-miR-6856-5p,hsa-miR-4999-5p,hsa-miR-4669, hsa-miR-497-5p, hsa-miR-5007-5p, hsa-miR-4484, hsa-miR-493-3p, hsa-miR-4510, hsa-miR-371a-3p, hsa-miR-329-5p, hsa-miR-4304, hsa-miR-10527-5p, hsa-miR-370-5p, hsa-miR-200a-5p, hsa-miR-4767, hsa-miR-6875-3p, hsa-miR-579-5p, hsa-miR-3151-5p, hsa-miR-938, hsa-miR-1260b,hsa-miR-498-3p,hsa-miR-3945,hsa-miR-656-5p,hsa-miR-4781-5p,hsa-miR-3679-5p,hsa-miR-525-3p,hsa-miR-3622a-3p,hsa-miR-6801-5p,hsa-miR-7850-5p,hsa-miR-515-5p,hsa-miR-1247-3p,hsa-miR-892c-5p,hsa-miR-6124,hsa-miR-1301-5p,hsa-miR-550a-5p,hsa- miR-4672, hsa-miR-6824-5p, hsa-miR-6893-3p, hsa-miR-10398-5p, hsa-miR-4299, hsa-miR-5002-3p, hsa-miR-3617-3p, hsa-miR-4462, hsa-miR-4660, hsa-miR-3934-5p, hsa-miR-3137, hsa-miR-4756-3p, hsa-miR-8080, hsa-miR-6859-5p, hsa-miR-6787-3p, hsa-miR-6511a-5p, hsa-miR-5708, hsa-miR-7846-3p,hsa-miR-378i,hsa-miR-595,hsa-miR-551b-3p,hsa-miR-7109-3p,hsa-miR-6715b-5p,hsa-miR-601,hsa-miR-323b-5p,hsa-miR-4269,hsa-miR-5588-3p,hsa-miR-11400,hsa-miR-6506-5p,hsa-miR-6884-5p,hsa-miR-4800-3p,hsa-miR-4522,hsa-miR-1269a,hsa-miR-8082,hsa-miR-6504-5p,hsa-miR-11181-3p,hsa-miR-4325,hsa-miR-106b-5p,hsa-miR-4252,hsa-miR-769-5p,hsa-miR-7113-3p,hsa-miR-4708-5p,hsa-miR-194-3p,hsa-miR-654-5p,hsa-miR-644a,hsa-miR-4700-5p,hsa-miR-8062,hsa-miR-6778-5p,hsa-miR-4703-3p,hsa-miR-3622b-5p,hsa-m iR-4661-5p, hsa-miR-4524b-5p, hsa-miR-1202, hsa-miR-10400-5p, hsa-miR-6846-5p, hsa-miR-4430, hsa-miR-6831-5p, hsa-miR-4737, hsa-miR-6749-3p, hsa-miR-3158-5p, hsa-miR-4511, hsa-miR-4706, hsa-miR-1273h-5p, hsa-miR-2110, hsa-miR-1322, hsa-miR-323a-5p, hsa-miR-6738-5p ,hsa-miR-1265,hsa-miR-4786-3p,hsa-miR-320d,hsa-miR-6788-5p,hsa-miR-6794-5p,hsa-miR-4682,hsa-miR-1228-5p,hsa-miR-5004-5p,hsa-miR-593-3p,hsa-miR-7843-5p,hsa-miR-4722-5p,hsa-miR-515-3p,hsa-miR-5089-5p,hsa-miR-6833-3p,hsa-miR-4721,hsa-miR-7849-3p,hsa-m iR-4488, hsa-miR-3168, hsa-miR-140-3p, hsa-miR-4482-3p, hsa-miR-6762-3p, hsa-miR-924, hsa-miR-5187-5p, hsa-miR-4653-3p, hsa-miR-7976, hsa-miR-3907, hsa-miR-6715b-3p, hsa-miR-6818-5p, hsa-miR-6810-5p, hsa-miR-1236-3p, hsa-miR-10401-3p, hsa-miR-4421, hsa-miR-6775-5p,hsa-miR-6736-3p,hsa-miR-4740-3p,hsa-miR-449c-5p,hsa-miR-6514-3p,hsa-miR-4316,hsa-miR-491-5p,hsa-miR-6886-5p,hsa-miR-7152-5p,hsa-miR-6789-3p,hsa-mi, R-382-3p,hsa-miR-4436b-5p,hsa-miR-7111-5p,hsa-miR-652-5p,hsa-miR-557,hsa-miR-365a-5p,hsa-miR-578,hsa-miR-3944-3p,hsa-miR-2277-5p,hsa-miR-6719-3p,hsa-miR-6516-5p,hsa-miR-708-5p,hsa-miR-1470,hsa-miR-4514,hsa-miR-3176,hsa-miR-4766-5p,hsa-miR-8074,hsa- miR-3655, hsa-miR-615-5p, hsa-miR-3163, hsa-miR-105-5p, hsa-miR-941, hsa-let-7b-5p, hsa-miR-187-3p, hsa-miR-4732-3p, hsa-miR-6716-3p, hsa-miR-1257, hsa-miR-4670-5p, hsa-miR-4540, hsa-miR-11401, hsa-miR-1298-3p, hsa-miR-4265, hsa-miR-338-5p, hsa-miR-124-3p, hsa-miR-6 850-3p,hsa-miR-675-3p,hsa-miR-99b-3p,hsa-miR-4273,hsa-miR-6812-5p,hsa-miR-3960,hsa-miR-632,hsa-miR-3085-5p,hsa-miR-214-3p,hsa-miR-6749-5p,hsa-miR-7975,hsa-miR-4710,hsa-miR-4283,hsa-miR-29a-3p,hsa-miR-3663-5p,hsa-miR-210-5p,hsa-miR-3158-3p,hsa-miR-1 2128,hsa-miR-4755-3p,hsa-miR-1306-3p,hsa-miR-3179,hsa-miR-4658,hsa-miR-3147,hsa-miR-6882-3p,hsa-miR-6874-5p,hsa-miR-1205,hsa-miR-5008-5p,hsa-miR-3689a-3p,hsa-miR-4732-5p,hsa-miR-6853-5p,hsa-miR-7109-5p,hsa-miR-381-5p,hsa-miR-4740-5p,hsa-miR-4684-5p,hsa-miR-3692-5p,hsa-miR-3935,hsa-miR-3941,hsa-miR-4639-3p,hsa-miR-488-5p,hs a-miR-6833-5p,hsa-miR-378f,hsa-miR-196b-3p,hsa-miR-6755-3p,hsa-miR-34a-5p,h sa-miR-517c-3p,hsa-miR-637,hsa-miR-6778-3p,hsa-miR-4691-5p,hsa-miR-4722-3p, hsa-miR-300, hsa-miR-891a-5p, hsa-miR-103a-1-5p, hsa-miR-219a-2-3p, hsa-miR-584- The present invention provides an extract of urine containing at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of miR-6735-5p, miR-433-5p, miR-4455, miR-1288-3p, miR-4635, miR-122-5p, miR-4717-3p, miR-6808-5p, miR-6772-3p, miR-6837-5p, miR-4761-3p, miR-3064-5p, miR-6510-5p, and miR-5587-3p. In the present disclosure, the urine extract may be an extract of urine from a breast cancer patient. A single one of these microRNAs can predict whether the subject from which the urine is derived is a breast cancer patient, and a combination of five or more, ten or more, fifteen or more, or twenty or more can predict whether the subject from which the urine is derived is a breast cancer patient. Among these microRNAs, microRNAs that are highly expressed in breast cancer patients can be preferably used for prediction.

[0035] According to the present disclosure, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-103a-3p, hsa-miR-107, hsa-miR-192-5p, hsa-miR-196a-5p, hsa-miR-197-3p, hsa-miR-129-5p, hsa-miR-34a-5p, hsa-miR-187-3p, hsa-miR-210-3p, hsa-miR-211-5p, hsa-miR-214-3p, hsa-miR-124-3p, hsa-miR-125b-5p, hsa-miR-138-5p, hsa-miR-149-5p, hsa-miR-184, hsa-miR-188-5p, hsa-miR-320a-3p, hsa-miR-106b-5p, hsa-miR-29c-3p, hsa-miR-299-3p, hsa-miR-361-5p, hsa-miR-370-3p, hsa-miR-373-5p, hsa-miR-�73-3p, hsa-miR-378a-3p, hsa-miR-379-5p, hsa-miR-383-5p, hsa-miR-328-3p, hsa-miR-342-3p, hsa-miR-326, hsa-miR-151a-3p, hsa-miR-325, hsa-miR-346, hsa-miR-424-5p, hsa-miR-20b-5p, hsa-miR-200a-5p, hsa-miR-323b-5p, hsa-miR-485-�p, hsa-miR-486-5p, hsa-miR-488-5p, hsa-miR-491-5p, hsa-miR-2〇2-3p, hsa-miR-492, hsa-miR-512-5p, hsa-miR-498-5p, hsa-miR-520c-3p, hsa-miR-519d-3p, hsa-miR-516b-3p, hsa-miR-516a-3p, hsa-miR-519a-3p, hsa-miR-502-5p, hsa-miR-493-3p, hsa-miR-551a, hsa-miR-552-3p, hsa-miR-554, hsa-miR-555, hsa-miR-557, hsa-miR-564, hsa-miR-572, hsa-miR-574-3p, hsa-miR-575, hsa-miR-576-5p, hsa-miR-578, hsa-miR-579-3p, hsa-miR-584-5p, It should be noted that there seems to be a typo in the original text where "hsa-miR-�73-3p" should probably be "hsa-miR-373-3p", and "hsa-miR-2〇2-3p" should probably be "hsa-miR-202-3p". The translation has been done as accurately as possible based on the provided text.hsa-miR-588,hsa-miR-595,hsa-miR-608,hsa-miR-610,hsa-miR-612,hsa-miR-614,hsa-miR-615-3p,hsa-miR-616-5p,hsa-miR-617,hsa-miR-628-3p,hsa-miR-629-3p,hsa-miR-632,hsa-miR-636,hsa-miR-637,hsa-miR-638,hsa-miR-639,hsa-miR-663a,hsa-miR-449b-5p,hsa-miR-657,hs a-miR-658,hsa-miR-542-5p,hsa-miR-671-5p,hsa-miR-668-3p,hsa-miR-769-5p,hsa-miR-769-3p,hsa-miR-766-3p,hsa-miR-765,hsa-miR-675-5p,hsa-miR-297,hsa-let-7d-3p,hsa-miR-24-2-5p,hsa-miR-25-5p,hsa-miR-26b-3p,hsa-miR-29a-5p,hsa-miR-92a-2-5p,hsa-miR-29b-1-5p, hsa-miR-139-3p, hsa-miR-187-5p, hsa-miR-214-5p, hsa-miR-30b-3p, hsa-miR-124-5p, hsa-miR-125b-1-3p, hsa-miR-130a-5p, hsa-miR-132-5p, hsa-miR-135a-3p, hsa-miR-140-3p, hsa-miR-125a-3p, hsa-miR-138-1-3p, hsa-miR-149-3p, hsa-miR-150-3p, hsa-miR-185-3p, hsa-miR-193a-5p p,hsa-miR-194-3p,hsa-miR-30c-1-3p,hsa-miR-34b-3p,hsa-miR-34c-3p,hsa-miR-99b-3p,hsa-miR-296-3p,hsa-miR-323a-5p,hsa-miR-423-5p,hsa-miR-20b-3p,hsa-miR-483-5p,hsa-miR-486-3p,hsa-miR-193b-5p,hsa-miR-508-5p,hsa-miR-532-3p,hsa-miR-92b-5p,hsa-miR-551b-5p,hsa-miR-574-5p, hsa-miR-550a-5p, hsa-miR-615-5p, hsa-miR-616-3p, hsa-miR-624-3p, hsa-miR-629-5p, hsa-miR-671-3p, hsa-miR-891a-5p, hsa-miR-874-3p, hsa-miR-891b, hsa-miR-892b, hsa-miR-744-5p, hsa-miR-885-5p, hsa-miR-885-3p, hsa-miR-877-5p, hsa-miR-877-3p, hsa-miR-887 -3p,hsa-miR-665,hsa-miR-760,hsa-miR-301b-3p,hsa-miR-920,hsa-miR-924,hsa-miR-509-3-5p,hsa-miR-936,hsa-miR-939-5p,hsa-miR-943,hsa-miR-1224-5p,hsa-miR-1224-3p,hsa-miR-1225-5p,hsa-miR-1225-3p,hsa-miR-1228-5p,hsa-miR-1228-3p,hsa-miR-1229-3p,hsa-miR-1231, hsa-miR-1233-3p,hsa-miR-1236-3p,hsa-miR-1237-3p,hsa-miR-1238-3p,hsa-miR-320c,hsa-miR-1182,hsa-miR-1202,hsa-miR-1203,hsa-miR-1204,hsa-miR-1207-5p,hsa-miR-1207-3p,hsa-miR-1286,hsa-miR-1293,hsa-miR-1294,hsa-miR-1303,hsa-miR-1304-5p,hsa-miR-1250-5p,hsa- miR-1257, hsa-miR-1260a, hsa-miR-1263, hsa-miR-1266-5p, hsa-miR-1268a, hsa-miR-1281, hsa-miR-1292-5p, hsa-miR-1306-3p, hsa-miR-1307-3p, hsa-miR-320d, hsa-miR-1825, hsa-miR-1468-5p, hsa-miR-675-3p, hsa-miR-1469, hsa-miR-1470, hsa-miR-1471, hsa-miR-1538, hsa-miR-1539,hsa-miR-1908-5p,hsa-miR-1909-5p,hsa-miR-1909-3p,hsa-miR-1910-5p,hsa-miR-1912-3p,hsa-miR-1914-3p,hsa-miR-1915-3p,hsa-miR-365a-5p,hsa-miR-449b-3p,hsa-miR-2113,hsa-miR-1976,hsa-miR-2110,hsa-miR-762,hsa-miR-670-5p,hsa-miR-548q,hsa-miR-2276-3p,hsa-miR- 711,hsa-miR-718,hsa-miR-2681-3p,hsa-miR-2682-3p,hsa-miR-449c-3p,hsa-miR-2861,hsa-miR-3120-3p,hsa-miR-3122,hsa-miR-3130-5p,hsa-miR-466,hsa-miR-3136-5p,hsa-miR-3137,hsa-miR-3138,hsa-miR-3141,hsa-miR-1273c,hsa-miR-3147,hsa-miR-3148,hsa-miR-3151-5p,hsa -miR-3153,hsa-miR-3154,hsa-miR-3157-5p,hsa-miR-3161,hsa-miR-3162-5p,hsa-miR-3163,hsa-miR-3165,hsa-miR-1260b,hsa-miR-3168,hsa-miR-3173-3p,hsa-miR-1193,hsa-miR-3175,hsa-miR-3176,hsa-miR-3177-3p,hsa-miR-3178,hsa-miR-3179,hsa-miR-3180-5p,hsa-miR-3180-3 p,hsa-miR-3185,hsa-miR-3187-3p,hsa-miR-3191-3p,hsa-miR-3194-5p,hsa-miR-3195,hsa-miR-3196,hsa-miR-3197,hsa-miR-3198,hsa-miR-3126-3p,hsa-miR-4296,hsa-miR-4297,hsa-miR-4293,hsa-miR-4294,hsa-miR-4298,hsa-miR-4305,hsa-miR-4315,hsa-miR-4316,hsa-miR-4314,hsa-miR-4320,hsa-miR-4322,hsa-miR-4321,hsa-miR-4323,hsa-miR-4324,hsa-miR-4256,hsa-miR-4257,hsa-miR-4258,hsa-miR-4259,hsa-miR-4260,hsa-miR-4253,hsa-miR-4252,hsa-miR-4325,hsa-miR-4326,hsa-miR-4327,hsa-miR-4265,hsa-miR-4269,hsa-miR-4271,hsa-miR-4276,hs a-miR-4279,hsa-miR-4278,hsa-miR-4280,hsa-miR-4285,hsa-miR-4283,hsa-miR-4289,hsa-miR-500b-5p,hsa-miR-2277-5p,hsa-miR-3200-5p,hsa-miR-3605-3p,hsa-miR-3610,hsa-miR-3616-3p,hsa-miR-3619-5p,hsa-miR-3620-3p,hsa-miR-3621,hsa-miR-3622a-5p,hsa-miR-3622a-3p,h sa-miR-3622b-5p,hsa-miR-3646,hsa-miR-3648,hsa-miR-3649,hsa-miR-3650,hsa-miR-3652,hsa-miR-3660,hsa-miR-3663-5p,hsa-miR-3663-3p,hsa-miR-3665,hsa-miR-3677-3p,hsa-miR-3679-5p,hsa-miR-3685,hsa-miR-3689a-3p,hsa-miR-3691-5p,hsa-miR-3180,hsa-miR-3907,hsa-mi R-3689b-3p,hsa-miR-3689c,hsa-miR-3908,hsa-miR-3911,hsa-miR-3917,hsa-miR-3918,hsa-miR-3919,hsa-miR-3150b-3p,hsa-miR-3926,hsa-miR-3928-3p,hsa-miR-3935,hsa-miR-3937,hsa-miR-3941,hsa-miR-3944-3p,hsa-miR-3945,hsa-miR-642b-3p,hsa-miR-550b-3p,hsa-miR-1268b,hsa-miR-378f,hsa-miR-4421,hsa-miR-4428,hsa-miR-4429,hsa-miR-4430,hsa-miR-4433a-3p,hsa-miR-4434,hsa-miR-4435,hsa-miR-4436a,hsa-miR-4437,hsa-miR-4439, ,hsa-miR-4440,hsa-miR-4443,hsa-miR-4446-3p,hsa-miR-4447,hsa-miR-4448,hsa-miR-4449,hsa-miR-4455,hsa-miR-4456,hsa-miR-4458,hsa-miR-4460,hsa-miR-378h,hsa-miR-3135b,hsa-miR-4462,hsa-miR-4463,hsa-miR-4466,hsa-miR-4467,hsa-miR-4472,hsa-miR-4474-3p,hsa-miR- 4476,hsa-miR-4478,hsa-miR-4479,hsa-miR-4481,hsa-miR-4483,hsa-miR-4484,hsa-miR-4486,hsa-miR-4487,hsa-miR-4488,hsa-miR-4489,hsa-miR-4492,hsa-miR-4497,hsa-miR-4498,hsa-miR-4505,hsa-miR-4506,hsa-miR-2392,hsa-miR-4507,hsa-miR-4508,hsa-miR-4510,hsa-miR-451 1,hsa-miR-4512,hsa-miR-4513,hsa-miR-4516,hsa-miR-4519,hsa-miR-4520-3p,hsa-miR-4521,hsa-miR-1269b,hsa-miR-4522,hsa-miR-4523,hsa-miR-4524a-3p,hsa-miR-4525,hsa-miR-4526,hsa-miR-4530,hsa-miR-4533,hsa-miR-4535,hsa-miR-1587,hsa-miR-4538,hsa-miR-4539,hsa-mi R-4540,hsa-miR-3120-5p,hsa-miR-3156-3p,hsa-miR-3158-5p,hsa-miR-3173-5p,hsa-miR-3187-5p,hsa-miR-3922-5p,hsa-miR-3925-3p,hsa-miR-3940-5p,hsa-miR-4520-5p,hsa-miR-3960,hsa-miR-3973,hsa-miR-4634,hsa-miR-4638-5p,hsa-miR-4639-3p,hsa-miR-4640-5p,hsa-miR-4643,hsa-miR-4644,hsa-miR-4646-5p,hsa-miR-4646-3p,hsa-miR-4647,hsa-miR-4648,hsa-miR-4649-5p,hsa-miR-4650-3p,hsa-miR-4651,hsa-miR-4653-3p,hsa-miR-4654,hsa-miR-4655-5p,hsa-miR-4656,hsa-miR-4661-5p,hsa-miR-4664-5p,hsa-miR-4665-5p,hsa-miR-4665-3p,hsa-miR- 4667-5p,hsa-miR-4669,hsa-miR-4670-5p,hsa-miR-4672,hsa-miR-4673,hsa-miR-4674,hsa-miR-4676-5p,hsa-miR-4682,hsa-miR-4685-5p,hsa-miR-4685-3p,hsa-miR-4686,hsa-miR-4687-5p,hsa-miR-1343-3p,hsa-miR-4688,hsa-miR-4690-5p,hsa-miR-4691-5p,hsa-miR-4691-3p,hsa- miR-4692, hsa-miR-4694-5p, hsa-miR-4695-5p, hsa-miR-4695-3p, hsa-miR-4697-5p, hsa-miR-4700-5p, hsa-miR-4701-3p, hsa-miR-4703-3p, hsa-miR-4704-5p, hsa-miR-4706, hsa-miR-4707-5p, hsa-miR-4707-3p, hsa-miR-4708-5p, hsa-miR-4708-3p, hsa-miR-203b-5p, hsa-miR-4710, hsa -miR-4711-3p,hsa-miR-4712-3p,hsa-miR-4713-5p,hsa-miR-4717-3p,hsa-miR-4720-5p,hsa-miR-4721,hsa-miR-4722-5p,hsa-miR-4722-3p,hsa-miR-4723-3p,hsa-miR-4724-5p,hsa-miR-4725-5p,hsa-miR-4725-3p,hsa-miR-4726-3p,hsa-miR-4728-3p,hsa-miR-4730,hsa-miR-4732-5p,hsa-miR-4732-3p,hsa-miR-4734,hsa-miR-4736,hsa-miR-3064-5p,hsa-miR-3064-3p,hsa-miR-4738-3p,hsa-miR-4739,hsa-miR-4740-3p,hsa-miR-4741,hsa-miR-4743-5p,hsa-miR-122b-3p,hsa-miR-4745-5p,hsa-miR-4746-3p,hsa-miR-4747-5p,hsa-miR-4747-3p,hsa-miR-4748,hsa-mi R-4749-5p,hsa-miR-4750-5p,hsa-miR-4753-5p,hsa-miR-371b-5p,hsa-miR-4754,hsa-miR-4755-3p,hsa-miR-4758-5p,hsa-miR-4758-3p,hsa-miR-4759,hsa-miR-4761-5p,hsa-miR-4763-5p,hsa-miR-4763-3p,hsa-miR-4766-5p,hsa-miR-4767,hsa-miR-4769-5p,hsa-miR-4769-3p,hsa-mi R-4772-5p, hsa-miR-4776-5p, hsa-miR-4776-3p, hsa-miR-4780, hsa-miR-4436b-5p, hsa-miR-4436b-3p, hsa-miR-4781-5p, hsa-miR-4783-3p, hsa-miR-4784, hsa-miR-2467-3p, hsa-miR-4787-5p, hsa-miR-4787-3p, hsa-miR-4793-3p, hsa-miR-4800-5p, hsa-miR-642a-3p, hsa-miR-550a-3-5p ,hsa-miR-4482-3p,hsa-miR-4999-5p,hsa-miR-5000-3p,hsa-miR-5001-5p,hsa-miR-5001-3p,hsa-miR-5002-3p,hsa-miR-5003-3p,hsa-miR-5006-5p,hsa-miR-5008-5p,hsa-miR-5010-5p,hsa-miR-5087,hsa-miR-5088-5p,hsa-miR-5089-5p,hsa-miR-5090,hsa-miR-5189-5p,hsa-miR-5190,hsa-miR-5196-5p,hsa-miR-4524b-5p,hsa-miR-5100,hsa-miR-5572,hsa-miR-664b-5p,hsa-miR-664b-3p,hsa-miR-548at-5p,hsa-miR-5585-3p,hsa-miR-548au-3p,hsa-miR-5588-5p,hsa-miR-5588-3p,hsa-miR-5589-5p,hsa-miR-5685,hsa-miR-5690,hsa-miR-5698,hsa-miR-5699-3p,hsa-m iR-5703, hsa-miR-5705, hsa-miR-5706, hsa-miR-5708, hsa-miR-197-5p, hsa-miR-204-3p, hsa-miR-211-3p, hsa-miR-301a-5p, hsa-miR-382-3p, hsa-miR-584-3p, hsa-miR-652-5p, hsa-miR-1185-2-3p, hsa-miR-766-5p, hsa-miR-1304-3p, hsa-miR-1247-3p, hsa-miR-1306-5p, hsa-miR-3184-3p, hsa-miR-3191-5p, hsa-miR-642b-5p, hsa-miR-3529-3p, hsa-miR-365b-5p, hsa-miR-3190-3p, hsa-miR-381-5p, hsa-miR-503-3p, hsa-miR-758-5p, hsa-miR-937-5p, hsa-miR-939-3p, hsa-miR-1227-5p, hsa-miR-1229-5p, hsa-miR-1236-5p, hsa-miR-1237-5p, hsa-miR-1238-5p, hsa-miR-3617-3p ,hsa-miR-3620-5p,hsa-miR-3927-5p,hsa-miR-3934-3p,hsa-miR-4632-5p,hsa-miR-4743-3p,hsa-miR-5739,hsa-miR-5787,hsa-miR-6068,hsa-miR-6069,hsa-miR-6071,hsa-miR-6072,hsa-miR-6073,hsa-miR-6075,hsa-miR-6076,hsa-miR-6081,hsa-miR-6083,hsa-miR-6085,hsa-miR-6088,hsa-miR-6089,hsa-miR-6090,hsa-miR-6124,hsa-miR-6125,hsa-miR-6126,hsa-miR-6127,hsa-miR-378j,hsa-miR-6131,hsa-miR-6132,hsa-miR-6133,hsa-miR-6500-3p,hsa-miR-6501-5p,hsa-miR-6501-3p,hsa-miR-6506-5p,hsa-miR-6509-3p,hsa-miR-6510-5p,hsa-miR-6511a-5p,hsa -miR-6511a-3p,hsa-miR-6512-3p,hsa-miR-6513-5p,hsa-miR-6514-3p,hsa-miR-6515-5p,hsa-miR-6515-3p,hsa-miR-6715b-3p,hsa-miR-6716-5p,hsa-miR-6716-3p,hsa-miR-6717-5p,hsa-miR-6511b-5p,hsa-miR-6511b-3p,hsa-miR-6719-3p,hsa-miR-6721-5p,hsa-miR-6722-5p,hsa-mi R-6722-3p,hsa-miR-6724-5p,hsa-miR-208a-5p,hsa-miR-210-5p,hsa-miR-128-1-5p,hsa-miR-370-5p,hsa-miR-328-5p,hsa-miR-329-5p,hsa- miR-410-5p,hsa-miR-487a-5p,hsa-miR-494-5p,hsa-miR-181d-3p,hsa-miR-504-3p,hsa-miR-487b-5p,hsa-miR-585-5p,hsa-miR-598-5p,hsa-m iR-605-3p, hsa-miR-619-5p, hsa-miR-655-5p, hsa-miR-1296-3p, hsa-miR-1301-5p, hsa-miR-874-5p, hsa-miR-1250-3p, hsa-miR-1266-3p, hsa-miR-1908-3p, hsa-miR-3151-3p, hsa-miR-500b-3p, hsa-miR-1343-5p, hsa-miR-5189-3p, hsa-miR-6726-5p, hsa-miR-6726-3p, hsa-miR-6727-5p,hsa-miR-6727-3p,hsa-miR-6728-5p,hsa-miR-6728-3p,hsa-miR-6729-5p,hsa-miR-6730-5p,hsa-miR-6730-3p,hsa-miR-6732-5p,hsa-miR-6732-3p,hsa-miR-6734-5p,hsa-miR-6735-5p, ,hsa-miR-6735-3p,hsa-miR-6736-5p,hsa-miR-6736-3p,hsa-miR-6737-5p,hsa-miR-6738-5p,hsa-miR-6738-3p,hsa-miR-6739-3p,hsa-miR-6740-5p,hsa-miR-6740-3p,hsa-miR-6741-5p,hsa-miR-6741-3p,hsa-miR-6742-5p,hsa-miR-6743-5p,hsa-miR-6743-3p,hsa-miR-6744-3p,hsa-miR -6747-5p,hsa-miR-6747-3p,hsa-miR-6748-5p,hsa-miR-6748-3p,hsa-miR-6749-5p,hsa-miR-6749-3p,hsa-miR-6750-3p,hsa-miR-6751-5p,hsa-miR-6751-3p,hsa-miR-6752-5p,hsa-miR-6753-5p,hsa-miR-6753-3p,hsa-miR-6754-5p,hsa-miR-6754-3p,hsa-miR-6756-5p,hsa-miR-6756-3p, hsa-miR-6759-5p,hsa-miR-6759-3p,hsa-miR-6761-3p,hsa-miR-6762-5p,hsa-miR-6762-3p,hsa-miR-6763-5p,hsa-miR-6763-3p,hsa-miR-6765-5p,hsa-miR-6766-5p,hsa-miR-6767-5p,hsa-miR-6768-5p,hsa-miR-6771-5p,hsa-miR-6772-5p,hsa-miR-6772-3p,hsa-miR-6773-3p,hsa-miR- 6775-5p,hsa-miR-6775-3p,hsa-miR-6776-5p,hsa-miR-6776-3p,hsa-miR-6777-5p,hsa-miR-6777-3p,hsa-miR-6778-5p,hsa-miR-6778-3p,hsa-miR-6779-3p,hsa-miR-6780a-3p,hsa-miR-6781-5p,hsa-miR-6782-5p,hsa-miR-6783-5p,hsa-miR-6783-3p,hsa-miR-6784-5p,hsa-miR-6786-5p,hsa-miR-6786-3p,hsa-miR-6787-5p,hsa-miR-6787-3p,hsa-miR-6788-5p,hsa-miR-6788-3p,hsa-miR-6789-5p,hsa-miR-6789-3p,hsa-miR-6790-5p,hsa-miR-6790-3p,hsa-miR-6791-5p,hsa-miR-6792-5p,hsa-miR-6792-3p,hsa-miR-6793-5p,hsa-miR-6794-5p,hsa-miR-6794-3p,hsa-miR- 6796-5p,hsa-miR-6797-5p,hsa-miR-6797-3p,hsa-miR-6798-5p,hsa-miR-6799-5p,hsa-miR-6800-5p,hsa-miR-6800-3p,hsa-miR-6801-5p,hsa-miR-6803-5p,hsa-miR-6803-3p,hsa-miR-6804-3p,hsa-miR-6805-5p,hsa-miR-6805-3p,hsa-miR-6806-5p,hsa-miR-6807-5p,hsa-miR-6808-5p,h sa-miR-6808-3p,hsa-miR-6809-5p,hsa-miR-6809-3p,hsa-miR-6810-5p,hsa-miR-6812-5p,hsa-miR-6813-5p,hsa-miR-6813-3p,hsa-miR-6815-3p,hsa-miR-6816-5p,hsa-miR-6818-5p,hsa-miR-6820-5p,hsa-miR-6821-5p,hsa-miR-6822-5p,hsa-miR-6822-3p,hsa-miR-6823-5p,hsa-miR-6 823-3p,hsa-miR-6824-5p,hsa-miR-6825-5p,hsa-miR-6825-3p,hsa-miR-6827-5p,hsa-miR-6829-5p,hsa-miR-6829-3p,hsa-miR-6830-5p,hsa-miR-6830-3p,hsa-miR-6831-5p,hsa-miR-6832-5p,hsa-miR-6833-5p,hsa-miR-6833-3p,hsa-miR-6834-5p,hsa-miR-6780b-5p,hsa-miR-6780b-3p,hsa-miR-6836-3p,hsa-miR-6837-5p,hsa-miR-6838-5p,hsa-miR-6839-5p,hsa-miR-6840-3p,hsa-miR-6842-5p,hsa-miR-6845-5p,hsa-miR-6845-3p,hsa-miR-6846-5p,hsa-miR-6847-5p,hsa-miR-6847-3p,hsa-miR-6848-5p,hsa-miR-6849-5p,hsa-miR-6849-3p,hsa-miR-6850-5p,hsa-miR -6851-5p,hsa-miR-6852-3p,hsa-miR-6855-5p,hsa-miR-6856-5p,hsa-miR-6857-5p,hsa-miR-6858-5p,hsa-miR-6858-3p,hsa-miR-6859-5p,hsa-miR-6769b-5p,hsa-miR-6860,hsa-miR-6861-5p,hsa-miR-6861-3p,hsa-miR-6862-3p,hsa-miR-6865-3p,hsa-miR-6867-5p,hsa-miR-6867-3p,h sa-miR-6868-3p,hsa-miR-6869-5p,hsa-miR-6870-5p,hsa-miR-6871-5p,hsa-miR-6872-3p,hsa-miR-6875-5p,hsa-miR-6875-3p,hsa-miR-6876-5p,hsa-miR-6876-3p,hsa-miR-6877-5p,hsa-miR-6877-3p,hsa-miR-6879-5p,hsa-miR-6879-3p,hsa-miR-6880-5p,hsa-miR-6880-3p,hsa-miR- 6881-5p,hsa-miR-6882-3p,hsa-miR-6883-3p,hsa-miR-6884-5p,hsa-miR-6886-3p,hsa-miR-6887-3p,hsa-miR-6889-5p,hsa-miR-6890-5p,hsa-miR-6891-5p,hsa-miR-6891-3p,hsa-miR-6892-5p,hsa-miR-6892-3p,hsa-miR-6893-5p,hsa-miR-6893-3p,hsa-miR-6894-5p,hsa-miR-6894-3p,hsa-miR-6895-5p,hsa-miR-6895-3p,hsa-miR-7106-5p,hsa-miR-7106-3p,hsa-miR-7107-5p,hsa-miR-7108-5p,hsa-miR-7108-3p,hsa-miR-7109-5p,hsa-miR-7109-3p,hsa-miR-7110-5p,hsa-miR-7110-3p,hsa-miR-7111-5p,hsa-miR-7111-3p,hsa-miR-7112-5p,hsa-miR-7113-5p,hsa-miR-7 113-3p,hsa-miR-7114-5p,hsa-miR-7150,hsa-miR-7151-3p,hsa-miR-7152-5p,hsa-miR-7155-5p,hsa-miR-7157-3p,hsa-miR-7158-3p,hsa-miR-7159-5p,hsa-miR-7160-5p,hsa-miR-7161-5p,hsa-miR-7162-5p,hsa-miR-7515,hsa-miR-7704,hsa-miR-7843-5p,hsa-miR-4433b-3p,hsa-miR-12 73h-5p,hsa-miR-6516-5p,hsa-miR-7845-5p,hsa-miR-7846-3p,hsa-miR-7847-3p,hsa-miR-7850-5p,hsa-miR-7851-3p,hsa-miR-7854-3p,hsa-miR-8052,hsa-miR-8059,hsa-miR-8062,hsa-miR-8063,hsa-miR-8064,hsa-miR-8069,hsa-miR-8071,hsa-miR-8072,hsa-miR-8073,hsa-miR-8074, hsa-miR-8075,hsa-miR-8077,hsa-miR-8080,hsa-miR-8085,hsa-miR-8089,hsa-miR-7976,hsa-miR-7977,hsa-miR-203a-5p,hsa-miR-1249-5p,hsa-miR-4485-5p,hsa-miR-8485,hsa-miR-103a-1-5p,hsa-miR-196a-1-3p,hsa-miR-217-3p,hsa-miR-375-5p,hsa-miR-498-3p,hsa-miR-1912-5p,hsa-miR-9718,hsa-miR-1843,hsa-miR-10392-5p,hsa-miR-10392-3p,hsa-miR-10394-3p, hsa-miR-10395-3p,hsa-miR-10396a-5p,hsa-miR-10396a-3p,hsa-miR-10398-5p,hsa-miR -10398-3p,hsa-miR-10400-5p,hsa-miR-10400-3p,hsa-miR-10401-5p,hsa-miR-10401-3p ,hsa-miR-10396b-5p,hsa-miR-10396b-3p,hsa-miR-10527-5p,hsa-miR-11181-5p,hsa-mi The present invention provides an extract of urine containing at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of hsa-miR-11181-3p, hsa-miR-11399, hsa-miR-11400, hsa-miR-11401, hsa-miR-3085-5p, hsa-miR-3085-3p, hsa-miR-6529-5p, hsa-miR-12114, hsa-miR-12115, hsa-miR-12118, hsa-miR-12119, hsa-miR-12120, hsa-miR-12121, hsa-miR-12124, hsa-miR-12126, and hsa-miR-12128. In the present disclosure, the urine extract may be an extract of urine from a stage I or II breast cancer patient. A single one of these microRNAs can predict whether the subject from which the urine is derived is a breast cancer patient (particularly stage I or II), and a combination of five or more, ten or more, fifteen or more, or twenty or more can predict whether the subject from which the urine is derived is a breast cancer patient (particularly stage I or II). Among these microRNAs, microRNAs that can be highly expressed in breast cancer patients (particularly stage I or II) can be preferably used for prediction.

[0036] According to the present disclosure, hsa-miR-29a-3p, hsa-miR-31-5p, hsa-miR-29b-3p, hsa-miR-124-3p, hsa-miR-184, hsa-miR-106b-5p, hsa-miR-299-3p, hsa-miR-361-5p, hsa-miR-370-3p, hsa-miR-373-3p, hsa-miR-379-5p, hsa-miR-335-5p, hsa-miR-325, hsa-miR-202-3p, hsa-miR-492, hsa-miR-498-5p, hsa-miR-555, hsa-miR-564, hsa-miR-572, hsa-miR-575, hsa-miR-578, hsa-miR-587, hsa-miR-610, hsa-miR-612, hsa-miR-617, hsa-miR-628-3p, hsa-miR-638, hsa-miR-639, hsa-miR-648, hsa-miR-663a, hsa-miR-658, hsa-miR-542-5p, hsa-miR-769-3p, hsa-miR-24-2-5p, hsa-miR-25-5p, hsa-miR-92a-2-5p, hsa-miR-139-3p, hsa-miR-187-5p, hsa-miR-30b-3p, hsa-miR-124-5p, hsa-miR-125b-1-3p, hsa-miR-130a-5p, hsa-miR-132-5p, hsa-miR-135a-3p, hsa-miR-149-3p, hsa-miR-185-3p, hsa-miR-193a-5p, hsa-miR-424-3p, hsa-miR-20b-3p, hsa-miR-486-3p, hsa-miR-193b-5p, hsa-miR-501-3p, hsa-miR-92b-5p, hsa-miR-551b-5p, hsa-miR-629-5p, hsa-miR-89hsa-miR-1207-5p,hsa-miR-1285-3p,hsa-miR-1293,hsa-miR-1294,hsa-miR-1299,hsa-miR-1304-5p,hsa-miR-1257,hsa-miR-1263,hsa-miR-1268a,hsa-miR-1281,hsa-miR-1292-5p,hsa-miR-320d,hsa-miR-1469,hsa-miR-1471,hsa-miR-1538,hsa-miR-1908-5p,hsa-miR-1909-3p,hsa-miR- 1912-3p,hsa-miR-1915-3p,hsa-miR-762,hsa-miR-548q,hsa-miR-718,hsa-miR-3120-3p,hsa-miR-3141,hsa-miR-1273c,hsa-miR-3161,hsa-miR-3162-5p,hsa-miR-1260b,hsa-miR-3168,hsa-miR-3173-3p,hsa-miR-1193,hsa-miR-3178,hsa-miR-3179,hsa-miR-3180-3p,hsa-miR-3185,hsa- miR-3187-3p, hsa-miR-3195, hsa-miR-3196, hsa-miR-3197, hsa-miR-4315, hsa-miR-4314, hsa-miR-4322, hsa-miR-4321, hsa-miR-4256, hsa-miR-4257, hsa-miR-4258, hsa-miR-4327, hsa-miR-4265, hsa-miR-4276, hsa-miR-4285, hsa-miR-3609, hsa-miR-3616-3p, hsa-miR-3621, hsa-miR-3648 ,hsa-miR-3652,hsa-miR-3660,hsa-miR-3663-3p,hsa-miR-3665,hsa-miR-3677-3p,hsa-miR-3180,hsa-miR-3907,hsa-miR-3917,hsa-miR-3919,hsa-miR-3928-3p,hsa-miR-3937,hsa-miR-1268b,hsa-miR-4428,hsa-miR-4429,hsa-miR-4430,hsa-miR-4433a-3p,hsa-miR-4434,hsa-miR-4435,hsa-miR-4439,hsa-miR-4440,hsa-miR-4443,hsa-miR-4446-3p,hsa-miR-4447,hsa-miR-4449,hsa-miR-4450,hsa-miR-4454,hsa-miR-4456,hsa-miR-4458,hsa-miR-378h,hsa-miR-3135b,hsa-miR-4466,hsa-miR-4467,hsa-miR-4468,hsa-miR-4479,hsa-miR-4481,hsa-miR-4486,hsa-miR-44 87,hsa-miR-4489,hsa-miR-4492,hsa-miR-4497,hsa-miR-4498,hsa-miR-4505,hsa-miR-4506,hsa-miR-4507,hsa-miR-4508,hsa-miR-4511,hsa-miR-4512,hsa-miR-4519,hsa-miR-4521,hsa-miR-1269b,hsa-miR-4530,hsa-miR-4533,hsa-miR-4535,hsa-miR-1587,hsa-miR-4538,hsa-miR-453 9,hsa-miR-3187-5p,hsa-miR-3940-5p,hsa-miR-4634,hsa-miR-4638-5p,hsa-miR-4639-5p,hsa-miR-4640-5p,hsa-miR-4648,hsa-miR-4650-3p,hsa-miR-4651,hsa-miR-4653-3p,hsa-miR-4654,hsa-miR-4655-5p,hsa-miR-4657,hsa-miR-4661-5p,hsa-miR-4665-5p,hsa-miR-4673,hsa-miR- 4674,hsa-miR-4687-5p,hsa-miR-4688,hsa-miR-4690-5p,hsa-miR-4691-3p,hsa-miR-4694-5p,hsa-miR-4695-5p,hsa-miR-4704-5p,hsa-miR-4707-5p,hsa-miR-4708-5p,hsa-miR-4708-3p,hsa-miR-4720-5p,hsa-miR-4724-5p,hsa-miR-4726-3p,hsa-miR-4730,hsa-miR-4734,hsa-miR-4736,hsa-miR-4738-3p,hsa-miR-4741,hsa-miR-4743-5p,hsa-miR-122b-3p,hsa-miR-4745-5p,hsa-miR-4746-3p,hsa-miR-4749-5p,hsa-miR-4750-5p,hsa-miR-371b-5p,hsa-miR-4754,hsa-miR-4755-3p,hsa-miR-4758-5p,hsa-miR-4759,hsa-miR-4763-3p,hsa-miR-4766-5p,hsa-miR-4781-5p,hsa -miR-4784,hsa-miR-4787-5p,hsa-miR-4520-2-3p,hsa-miR-4482-3p,hsa-miR-5001-5p,hsa-miR-5010-5p,hsa-miR-5088-5p,hsa-miR-5089-5p,hsa-miR-5090,hsa-miR-5189-5p,hsa-miR-5100,hsa-miR-5572,hsa-miR-5585-3p,hsa-miR-548au-3p,hsa-miR-5690,hsa-miR-5698,hsa-miR-5699 -3p,hsa-miR-5703,hsa-miR-5706,hsa-miR-197-5p,hsa-miR-211-3p,hsa-miR-766-5p,hsa-miR-3529-3p,hsa-miR-937-5p,hsa-miR-1227-5p,hsa-miR-1236-5p,hsa-miR-1237-5p,hsa-miR-3620-5p,hsa-miR-3934-3p,hsa-miR-4632-5p,hsa-miR-5787,hsa-miR-6068,hsa-miR-6071,hsa-miR-6 075,hsa-miR-6076,hsa-miR-6081,hsa-miR-6089,hsa-miR-6090,hsa-miR-6125,hsa-miR-6126,hsa-miR-6127,hsa-miR-6131,hsa-miR-6132,hsa-miR-6500-3p,hsa-miR-6501-5p,hsa-miR-6501-3p,hsa-miR-6511a-5p,hsa-miR-6513-5p,hsa-miR-6719-3p,hsa-miR-6721-5p,hsa-miR-6722-3p,hsa-miR-6724-5p,hsa-miR-208a-5p,hsa-miR-128-1-5p,hsa-miR-181d-3p,hsa-miR-504-3p,hsa-miR-605-3p,hsa-miR-1343-5p,hsa-miR-5189-3p,hsa-miR-6726-5p,hsa-miR-6727-5p,hsa-miR-6729-5p,hsa-miR-6732-5p,hsa-miR-6737-5p,hsa-miR-6743-5p,hsa-miR-6750-5p,hsa-miR- 6751-5p, hsa-miR-6752-5p, hsa-miR-6753-5p, hsa-miR-6756-5p, hsa-miR-6759-5p, hsa-miR-6762-5p, hsa-miR-6763-5p, hsa-miR-6766-5p, hsa-miR-6768-5p, hsa-miR-6772-5p, hsa-miR-6776-5p, hsa-miR-6777-5p, hsa-miR-6781-5p, hsa-miR-6782-5p, hsa-miR-6784-5p, hsa-miR-6786-5p ,hsa-miR-6787-5p,hsa-miR-6789-5p,hsa-miR-6790-5p,hsa-miR-6791-5p,hsa-miR-6792-5p,hsa-miR-6793-5p,hsa-miR-6794-5p,hsa-miR-6796-5p,hsa-miR-6798-5p,hsa-miR-6799-5p,hsa-miR-6800-5p,hsa-miR-6805-5p,hsa-miR-6813-5p,hsa-miR-6816-5p,hsa-miR-6818-5p,hsa-mi R-6820-5p,hsa-miR-6821-5p,hsa-miR-6823-5p,hsa-miR-6829-5p,hsa-miR-6832-5p,hsa-miR-6836-5p,hsa-miR-6839-5p,hsa-miR-6840-3p,hsa-miR-6842-5p,hsa-miR-6845-5p,hsa-miR-6847-5p,hsa-miR-6848-5p,hsa-miR-6849-5p,hsa-miR-6850-5p,hsa-miR-6860,hsa-miR-6861-5p,hsa-miR-6869-5p,hsa-miR-6870-5p,hsa-miR-6871-5p,hsa-miR-6875-5p,hsa-miR-6876-5p,hsa-miR-6877-5p,hsa-miR-6879-5p,hsa-miR-6893-5p,hsa-miR-6894-5p,hsa-miR, -6895-5p,hsa-miR-7108-5p,hsa-miR-7110-5p,hsa-miR-7112-5p,hsa-miR-7114-5p,hsa-miR-7150,hsa-miR-7 157-3p,hsa-miR-7158-3p,hsa-miR-7160-5p,hsa-miR-7515,hsa-miR-7704,hsa-miR-4433b-3p,hsa-miR-6516-5 p,hsa-miR-7851-3p,hsa-miR-7854-3p,hsa-miR-8059,hsa-miR-8063,hsa-miR-8064,hsa-miR-8069,hsa-miR-80 71,hsa-miR-8072,hsa-miR-8075,hsa-miR-8077,hsa-miR-8078,hsa-miR-8089,hsa-miR-7976,hsa-miR-1249-5p ,hsa-miR-375-5p,hsa-miR-526a-3p,hsa-miR-9718,hsa-miR-10392-5p,hsa-miR-10392-3p,hsa-miR-10394-3p, hsa-miR-10395-3p,hsa-miR-10396a-5p,hsa-miR-10396a-3p,hsa-miR-10398-3p,hsa-miR-10400-3p,hsa-miR-1 A urine extract is provided, comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of miR-0401-5p, miR-10396b-5p, miR-11399, miR-12114, miR-12118, miR-12119, miR-12120, and miR-12121. In the present disclosure, the urine extract may be a urine extract from a stage I breast cancer patient. A single microRNA can predict whether a subject from whom the urine is obtained has breast cancer (particularly stage I), and a combination of five or more, ten or more, fifteen or more, or twenty or more microRNAs can predict whether a subject from whom the urine is obtained has breast cancer (particularly stage I). Among these microRNAs, microRNAs that can be highly expressed in breast cancer patients (particularly in stage I) can be preferably used for prediction.

[0037] The present disclosure provides a urine extract containing at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of microRNAs listed in Table 24-2 that showed a correct answer rate (accuracy; when expressed as a percentage, multiply by 100; for example, 0.5 is 50%) of more than 0.500. In the present disclosure, the urine extract may be an extract of urine from a breast cancer patient. A single one of these microRNAs can predict whether or not the subject from whom the urine is derived is a breast cancer patient, and a combination of five or more, ten or more, fifteen or more, or twenty or more can predict whether or not the subject from whom the urine is derived is a breast cancer patient. Of these microRNAs, microRNAs that can be highly expressed in breast cancer patients can be preferably used for prediction. In certain embodiments, the accuracy can be greater than 0.5, 0.55 or more, 0.6 or more, 0.65 or more, 0.7 or more, 0.75 or more, 0.8 or more, 0.85 or more, or 0.9 or more.

[0038] The present disclosure also provides a urine extract containing at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of the microRNAs listed in Table 25-2 that showed an accuracy of greater than 0.500. In the present disclosure, the urine extract may be an extract of urine from a breast cancer patient. A single one of these microRNAs can predict whether or not a subject from whom the urine is derived is a breast cancer patient, and a combination of five or more, ten or more, fifteen or more, or twenty or more can predict whether or not a subject from whom the urine is derived is a breast cancer patient. Of these microRNAs, microRNAs that can be highly expressed in breast cancer patients are preferably used for prediction. In certain embodiments, the accuracy may be greater than 0.5, 0.55 or more, 0.6 or more, 0.65 or more, 0.7 or more, 0.75 or more, 0.8 or more, 0.85 or more, or 0.9 or more.

[0039] In another aspect of the present disclosure, there is provided an extract of urine comprising at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the microRNAs listed in Table 4-3. This disclosure also provides hsa-miR-498-5p, hsa-miR-551b-5p, hsa-miR-10526-3p, hsa-miR-150-3p, hsa-miR-5196-5p, hsa-miR-6809-5p, hsa-miR-6 783-5p,hsa-miR-3059-3p,hsa-miR-4433b-3p,hsa-miR-6794-5p,hsa-miR-3124-5p,hsa-miR-1207-5p,hsa-miR-424-3p,hsa-miR-62 9-5p,hsa-miR-4327,hsa-miR-4258,hsa-miR-4447,hsa-miR-6796-3p,hsa-miR-3648,hsa-miR-10392-3p,hsa-miR-7111-5p,hsa-mi R-1914-3p,hsa-miR-1268b,hsa-miR-9898,hsa-miR-6805-3p,hsa-miR-4314,hsa-miR-4433b-5p,hsa-miR-6763-3p,hsa-miR-3937,h sa-miR-4433a-5p,hsa-miR-7108-3p,hsa-miR-605-3p,hsa-miR-4433a-3p,hsa-miR-7150,hsa-miR-4665-5p,hsa-miR-6746-5p,hsa -miR-4758-5p,hsa-miR-6781-5p,hsa-miR-6891-3p,hsa-miR-10396a-3p,hsa-miR-4651,hsa-miR-6859-3p,hsa-miR-12116,hsa-miR -1249-3p,hsa-miR-10400-3p,hsa-miR-202-3p,hsa-miR-6829-5p,hsa-miR-6760-3p,hsa-miR-92a-2-5p,hsa-miR-4725-3p,hsa-mi R-6784-3p,hsa-miR-1224-3p,hsa-miR-6731-3p,hsa-miR-1228-3p,hsa-miR-3197,hsa-miR-7515,hsa-miR-6125,hsa-miR-6798-3p,hsa-miR-6729-3p, hsa-miR-1343-5p, hsa-miR-6749-5p, hsa-miR-6892-3p, hsa-miR-3162-3p, hsa-miR-4716-5p, hsa-miR-4257, hsa-miR-5703, hsa-miR-10522-5p, hsa-miR-1185-2-3p, hsa-miR-6810-3p, hsa-miR-6515-3p, hsa-miR-6785-3p, hsa-miR-196a-5p, hsa-miR-6832-5p, hsa-miR-475 5-3p,hsa-miR-4720-5p,hsa-miR-6812-3p,hsa-miR-3679-3p,hsa-miR-6763-5p,hsa-miR-4750-3p,hsa-miR-6800-3p,hsa-miR-6780b-5p,hsa-miR-6836-3p,hsa-miR-3660,hsa-miR-1185-1-3p,hsa-miR-4429,hsa-miR-6777-3p,hsa-miR-4521,hsa-miR-519c-5p,hsa-miR-523-5p,hsa-miR-518 e-5p, hsa-miR-522-5p, hsa-miR-519a-5p, hsa-miR-519b-5p, hsa-miR-6858-3p, hsa-miR-135a-2-3p, hsa-miR-1908-5p, hsa-miR-1238-3p, hsa-miR-4749-3p, hsa-miR-6789-5p, hsa-miR-135a-3p, hsa-miR-2115-5p, hsa-miR-7851-3p, hsa-miR-617, hsa-miR-1913, hsa-miR-4274, hsa-miR-1225 -3p,hsa-miR-4749-5p,hsa-miR-6766-3p,hsa-miR-4665-3p,hsa-miR-6813-3p,hsa-miR-6791-5p,hsa-miR-6845-3p,hsa-miR-106a-3p,hsa-miR-6880-3p,hsa-miR-1237-3p,hsa-miR-3186-3p,hsa-miR-4261,hsa-miR-4741,hsa-miR-4745-5p,hsa-miR-7114-3p,hsa-miR-4323,hsa-miR-12120,hsa-miR-4294,hsa-miR-3675-3p,hsa-miR-6795-3p,hsa-miR-766-5p,hsa-miR-12122,hsa-miR-940,hsa-miR-20b-3p,hsa-miR-10401-5p,hsa-miR-12119,hsa-miR-6797-5p,hsa-miR-6750-5p,hsa-miR-4458,hsa-miR-4763-3p,hsa-miR-3141,hsa-miR-8072,hsa-miR-625-3p,hsa-miR-3199,hs a-miR-6819-3p,hsa-miR-6756-3p,hsa-miR-638,hsa-miR-937-5p,hsa-miR-6081,hsa-miR-4313,hsa-miR-1285-3p,hsa-miR-665,hsa-miR-1470,hsa-miR-6893-5p,hsa-miR-4484,hsa-miR-6790-3p,hsa-miR-4450,hsa-miR-4507,hsa-miR-6874-5p,hsa-miR-4505,hsa-miR-6074,hsa-miR-1227- 5p,hsa-miR-1915-3p,hsa-miR-151a-5p,hsa-miR-7114-5p,hsa-miR-711,hsa-miR-494-3p,hsa-miR-4728-3p,hsa-miR-7107-5p,hsa-miR-1292-5p,hsa-miR-939-5p,hsa-miR-6884-3p,hsa-miR-1236-3p,hsa-miR-4731-3p,hsa-miR-541-3p,hsa-miR-6743-5p,hsa-miR-5585-3p,hsa-miR-6805-5 p,hsa-miR-4299,hsa-miR-6732-5p,hsa-miR-193a-5p,hsa-miR-1225-5p,hsa-miR-18b-3p,hsa-miR-6752-3p,hsa-miR-6887-3p,hsa-miR-302a-3p,hsa-miR-6850-5p,hsa-miR-3150b-5p,hsa-miR-6131,hsa-miR-6870-3p,hsa-miR-6758-5p,hsa-miR-210-5p,hsa-miR-628-3p,hsa-miR-193b-5p,hsa-miR-3682-3p,hsa-miR-6124,hsa-miR-6752-5p,hsa-miR-4435,hsa-miR-4465,hsa-miR-6515-5p,hsa-miR-3614-5p,hsa-miR-4286,hsa-miR-92b-5p,hsa-miR-6516-5p,hsa-miR-6887-5p,hsa-miR-6855-5p,hsa-miR-4300,hsa-miR-1293,hsa-miR-6815-5p,hsa-miR-6165,hsa-miR-4466,hs a-miR-11399,hsa-miR-3184-3p,hsa-miR-6776-5p,hsa-miR-361-3p,hsa-miR-6840-3p,hsa-miR-6847-5p,hsa-miR-6799-5p,hsa-miR-1304-3p,hsa-miR-6845-5p,hsa-miR-3943,hsa-miR-3161,hsa-miR-6777-5p,hsa-miR-4321,hsa-miR-6795-5p,hsa-miR-3162-5p,hsa-miR-6876-5p,hsa-miR- 138-5p,hsa-miR-3131,hsa-miR-6798-5p,hsa-miR-3127-3p,hsa-miR-1303,hsa-miR-4283,hsa-miR-10392-5p,hsa-miR-5003-3p,hsa-miR-5685,hsa-miR-6069,hsa-miR-4687-5p,hsa-miR-4701-3p,hsa-miR-7113-5p,hsa-miR-10396b-5p,hsa-miR-4654,hsa-miR-197-5p,hsa-miR-3620-5p,hsa -miR-7109-5p,hsa-miR-1469,hsa-miR-6821-5p,hsa-miR-4530,hsa-miR-5739,hsa-miR-3934-5p,hsa-miR-3085-3p,hsa-miR-320c,hsa-miR-3163,hsa-miR-4472,hsa-miR-6871-5p,hsa-miR-6788-5p,hsa-miR-4648,hsa-miR-601,hsa-miR-5698,hsa-miR-4284,hsa-miR-708-5p,hsa-miR-4784,hsa-miR-6729-5p,hsa-miR-296-5p,hsa-miR-4778-5p,hsa-miR-769-3p,hsa-miR-3689b-3p,hsa-miR-3689c,hsa-miR-1281,hsa-miR-7151-3p,hsa-miR-4716-3p,hsa-miR-4650-3p,hsa-miR-6086,hsa-miR-5009-3p,hsa-miR-6747-5p,hsa-miR-4298,hsa-miR-10398-3p,hsa-miR-6068,hsa- miR-4497, hsa-miR-4474-3p, hsa-miR-4727-3p, hsa-miR-6085, hsa-miR-6879-5p, hsa-miR-211-3p, hsa-miR-365a-5p, hsa-miR-4657, hsa-miR-1236-5p, hsa-miR-4525, hsa-miR-365a-3p, hsa-miR-365b-3p, hsa-miR-6756-5p, hsa-miR-3610, hsa-miR-4487, hsa-miR-6721-5p, hsa-miR-4534, h sa-miR-324-5p,hsa-miR-187-5p,hsa-miR-6127,hsa-miR-4535,hsa-miR-4673,hsa-miR-6889-5p,hsa-miR-6861-5p,hsa-miR-6812-5p,hsa-miR-7154-3p,hsa-miR-3652,hsa-miR-3187-3p,hsa-miR-8082,hsa-miR-6761-5p,hsa-miR-6717-5p,hsa-miR-6748-5p,hsa-miR-6848-3p,hsa-miR-4 695-5p,hsa-miR-323b-5p,hsa-miR-3185,hsa-miR-6786-5p,hsa-miR-29a-3p,hsa-miR-6790-5p,hsa-miR-2467-3p,hsa-miR-5004-3p,hsa-miR-4649-3p,hsa-miR-1587,hsa-miR-8064,hsa-miR-6511a-5p,hsa-miR-593-3p,hsa-miR-4734,hsa-miR-8077,hsa-miR-4707-5p,hsa-miR-6797-3p,hsa-miR-4728-5p,hsa-miR-4499,hsa-miR-1471,hsa-miR-6841-3p,hsa-miR-484,hsa-miR-4647,hsa-miR-3133,hsa-miR-5010-5p,hsa-miR-4769-5p,hsa-miR-4506, ,hsa-miR-12114,hsa-miR-4280,hsa-miR-4436b-3p,hsa-miR-718,hsa-miR-184,hsa-miR-6529-5p,hsa-miR-5187-5p,hsa-miR-492,hsa-miR-4467,hsa-miR-6823-5p,hsa-miR-6875-5p,hsa-miR-6083,hsa-miR-381-5p,hsa-miR-518b,hsa-miR-30b-3p,hsa-miR-6772-5p,hsa-miR-6782-5p, hsa-miR-4747-5p,hsa-miR-3135b,hsa-miR-3691-5p,hsa-miR-3622a-5p,hsa-miR-6814-5p,hsa-miR-6861-3p,hsa-miR-7156-3p,hsa-miR-1910-3p,hsa-miR-4498,hsa-miR-515-5p,hsa-miR-6892-5p,hsa-miR-8080,hsa-miR-4776-3p,hsa-miR-6859-5p,hsa-miR-4482-3p,hsa-miR-6089,hs a-miR-6514-5p, hsa-miR-6511b-5p, hsa-miR-6759-5p, hsa-miR-6724-5p, hsa-miR-516a-5p, hsa-miR-3180-5p, hsa-miR-1268a, hsa-miR-4428, hsa-miR-125b-2-3p, hsa-miR-204-3p, hsa-miR-504-5p, hsa-miR-3180-3p, hsa-miR-1909-3p, hsa-miR-3619-3p, hsa-miR-5584-5p, hsa-miR-3200 -5p,hsa-miR-4638-5p,hsa-miR-6071,hsa-miR-6787-5p,hsa-miR-6839-5p,hsa-miR-130b-3p,hsa-miR-7847-3p,hsa-miR-5194,hsa-miR-5006-5p,hsa-miR-6848-5p,hsa-miR-4688,hsa-miR-6830-5p,hsa-miR-3922-5p,hsa-miR-371b-5p,hsa-miR-6770-5p,hsa-miR-575,hsa-miR-6726-5p,hsa-miR-1306-3p,hsa-miR-5190,hsa-miR-6820-5p,hsa-miR-6741-5p,hsa-miR-595,hsa-miR-6749-3p,hsa-miR-7856-5p,hsa-miR-5090,hsa-miR-4316,hsa-miR-8083,hsa-miR-4783-3p,hsa-miR-370-3p,hsa-miR-3178,hsa-miR-487a-5p,hsa-miR-3917,hsa-miR-921,hsa-miR-6836-5p,hsa- miR-6075,hsa-miR-4664-5p,hsa-miR-5588-3p,hsa-let-7d-3p,hsa-miR-762,hsa-miR-3122,hsa-miR-619-5p,hsa-miR-9718,hsa-miR-584-5p,hsa-miR-6775-3p,hsa-miR-3192-5p,hsa-miR-8071,hsa-miR-4489,hsa-miR-4644,hsa-miR-4692,hsa-miR-4508,hsa-miR-6768-5p,hsa-miR-760,hs a-miR-206, hsa-miR-516b-3p, hsa-miR-516a-3p, hsa-miR-6766-5p, hsa-miR-2681-3p, hsa-miR-6090, hsa-miR-4708-3p, hsa-miR-3196, hsa-miR-4516, hsa-miR-6852-5p, hsa-miR-4769-3p, hsa-miR-6769b-5p, hsa-miR-139-3p, hsa-miR-6796-5p, hsa-miR-7160-5p, hsa-miR-572, hsa-miR-4439 ,hsa-miR-6076,hsa-miR-7850-5p,hsa-miR-4682,hsa-miR-378j,hsa-miR-4481,hsa-miR-11181-3p,hsa-miR-6793-5p,hsa-miR-6834-5p,hsa-miR-4781-5p,hsa-miR-3158-3p,hsa-miR-3150b-3p,hsa-miR-4317,hsa-miR-3155b,hsa-miR-7107-3p,hsa-miR-25-5p,hsa-miR-4748,hsa-miR-4456,hsa-miR-5093,hsa-miR-5708,hsa-miR-6767-5p,hsa-miR-550a-3-5p,hsa-miR-7108-5p,hsa-miR-933,hsa-miR-4430,hsa-miR-6722-3p,hsa-miR-4478,hsa-miR-650,hsa-miR-6132,hsa-miR-378a-3p,hsa-miR-8085,hsa-miR-4754,hsa-miR-4676-5p,hsa-miR-644a,hsa-miR-1234-3p,hsa-miR -4632-5p,hsa-miR-4531,hsa-miR-7854-3p,hsa-miR-4271,hsa-miR-4640-5p,hsa-miR-6775-5p,hsa-miR-342-5p,hsa-miR-4449,hsa-miR-583,hsa-miR-30c-2-3p,hsa-miR-6504-3p,hsa-miR-5100,hsa-miR-9986,hsa-miR-449b-5p,hsa-miR-11401,hsa-miR-548g-3p,hsa-miR-1204,hsa-miR-1 05-5p,hsa-miR-4538,hsa-miR-4686,hsa-miR-874-5p,hsa-miR-1237-5p,hsa-miR-4513,hsa-miR-4667-5p,hsa-miR-7110-5p,hsa-miR-663a,hsa-miR-3689a-3p,hsa-miR-4743-5p,hsa-miR-3154,hsa-miR-6760-5p,hsa-miR-7162-3p,hsa-miR-3187-5p,hsa-miR-448,hsa-miR-4486,hsa-miR-52 5-5p,hsa-miR-4444,hsa-miR-1294,hsa-miR-7106-5p,hsa-miR-3195,hsa-miR-4522,hsa-miR-4463,hsa-miR-6730-5p,hsa-miR-185-3p,hsa-miR-4723-5p,hsa-miR-3619-5p,hsa-miR-6846-5p,hsa-miR-4510,hsa-miR-4779,hsa-miR-5572,hsa-miR-483-5p,hsa-miR-6855-3p,hsa-miR-328-3p,hsa-miR-4475,hsa-miR-4800-5p,hsa-miR-6737-5p,hsa-miR-338-5p,hsa-miR-8069,hsa-miR-1276,hsa-miR-6500-3p,hsa-miR-550b-2-5p,hsa-miR-4440,hsa-miR-3612,hsa-miR-2116-3p,hsa-miR-5189-5p,hsa-miR-183-3p,hsa-miR-373-5p,hsa-miR-4540,hsa-miR-4311,hsa-miR-1468-5p, hsa-miR-12118,hsa-miR-4750-5p,hsa-miR-1298-5p,hsa-miR-8070,hsa-miR-3909,hsa-miR-4303,hsa-miR-4251,hsa-miR-1233-5p,hsa-miR-4306,hsa-miR-6876-3p,hsa-miR-504-3p,hsa-miR-6784-5p,hsa-miR-3617-3p,hsa-miR-4786-5p,hsa-miR-610,hsa-miR-3654,hsa-miR-5189-3p,hsa -miR-200b-3p,hsa-miR-2110,hsa-miR-4685-5p,hsa-miR-6842-5p,hsa-miR-378i,hsa-miR-10396a-5p,hsa-miR-3621,hsa-miR-3064-5p,hsa-miR-1238-5p,hsa-miR-4470,hsa-miR-6837-5p,hsa-miR-486-3p,hsa-miR-4441,hsa-miR-6792-5p,hsa-miR-4421,hsa-miR-520e-3p,hsa-miR-765,hs a-miR-4674,hsa-miR-4707-3p,hsa-miR-6886-5p,hsa-miR-5589-5p,hsa-miR-622,hsa-miR-4684-3p,hsa-miR-6895-5p,hsa-miR-5007-5p,hsa-miR-4756-3p,hsa-miR-6884-5p,hsa-miR-10395-5p,hsa-miR-3928-3p,hsa-miR-658,hsa-miR-520c-3p,hsa-miR-8089,hsa-miR-761,hsa-miR-4736,hsa-miR-433-5p,hsa-miR-1301-5p,hsa-miR-4758-3p,hsa-miR-4723-3p,hsa-miR-4785,hsa-miR-3137,hsa-miR-6802-3p,hsa-miR-2276-3p,hsa-miR-4717-5p,hsa-miR-99b-3p,hsa-miR-149-3p,hsa-miR-323a-3p,hsa-miR-4794,hsa-miR-4496,hsa-miR-4437,hsa-miR-8078,hsa-miR-16-2- 3p,hsa-miR-885-3p,hsa-miR-6512-3p,hsa-miR-1266-3p,hsa-miR-1843,hsa-miR-3667-5p,hsa-miR-4446-3p,hsa-miR-6825-5p,hsa-miR-6510-5p,hsa-miR-6880-5p,hsa-miR-3665,hsa-miR-6762-3p,hsa-miR-1289,hsa-miR-6831-5p,hsa-miR-4451,hsa-miR-3934-3p,hsa-miR-491-5p,hsa- miR-6833-5p, hsa-miR-6868-3p, hsa-miR-4526, hsa-miR-4786-3p, hsa-miR-34a-5p, hsa-miR-4738-3p, hsa-miR-3151-5p, hsa-miR-520b-3p, hsa-miR-4448, hsa-miR-4304, hsa-miR-5580-5p, hsa-miR-6885-3p, hsa-miR-6877-5p, hsa-miR-6740-5p, hsa-miR-373-3p, hsa-miR-3169, hsa-miR-50 02-3p,hsa-miR-4669,hsa-miR-4431,hsa-miR-8075,hsa-miR-26b-3p,hsa-miR-23a-5p,hsa-miR-4656,hsa-miR-302d-5p,hsa-miR-6738-3p,hsa-miR-6793-3p,hsa-miR-564,hsa-miR-4706,hsa-miR-3155a,hsa-miR-4454,hsa-miR-887-3p,hsa-miR-1269a,hsa-miR-6770-3p,hsa-miR-200c-5p,hsa-miR-557,hsa-miR-5690,hsa-miR-6773-3p,hsa-miR-1972,hsa-miR-6843-3p,hsa-miR-652-5p,hsa-miR-34c-5p,hsa-miR-550a-5p,hsa-miR-642a-3p,hsa-miR-6822, -3p,hsa-miR-5787,hsa-miR-4776-5p,hsa-miR-1301-3p,hsa-miR-3679-5p,hsa-miR-7152-3p,hsa-miR-8057,hsa-miR-296-3p,hsa-miR-6849-5p,hsa-miR-6801-5p,hsa-miR-3138,hsa-miR-1224-5p,hsa-miR-3142,hsa-miR-6869-5p,hsa-miR-500b-3p,hsa-miR-4740-3p,hsa-miR-877-5p,hs a-miR-18a-3p,hsa-miR-548q,hsa-miR-4483,hsa-miR-1270,hsa-miR-374a-3p,hsa-miR-200c-3p,hsa-miR-125b-1-3p,hsa-miR-3176,hsa-miR-122b-3p,hsa-miR-5088-5p,hsa-miR-6813-5p,hsa-miR-4533,hsa-miR-6778-5p,hsa-miR-6126,hsa-miR-3120-3p,hsa-miR-920,hsa-miR-12127,hs a-let-7f-1-3p,hsa-miR-302c-5p,hsa-miR-4658,hsa-miR-4539,hsa-miR-323a-5p,hsa-miR-6769a-5p,hsa-miR-4265,hsa-miR-1322,hsa-miR-6862-5p,hsa-miR-6727-5p,hsa-miR-342-3p,hsa-miR-4713-3p,hsa-miR-6889-3p,hsa-miR-4455,hsa-miR-214-3p,hsa-miR-6894-5p,hsa-miR-39 45,hsa-miR-4726-3p,hsa-miR-6501-3p,hsa-miR-3085-5p,hsa-miR-4787-5p,hsa-miR-6856-5p,hsa-miR-501-5p,hsa-miR-6870-5p,hsa-miR-598-5p,hsa-miR-370-5p,hsa-miR-6742-5p,hsa-miR-1247-3p,hsa-miR-6129,hsa-miR-6728-5p,hsa-miR-3173-5p,hsa-miR-3649,hsa-miR-585-5p,hsa-miR-3190-3p,hsa-miR-1203,hsa-miR-466,hsa-miR-4746-3p,hsa-miR-892b,hsa-miR-632,hsa-miR-5705,hsa-miR-3646,hsa-miR-5581-5p,hsa-miR-6738-5p,hsa-miR-642b-3p,hsa-miR-133a-3p,hsa-miR-608,hsa-miR-3125,hsa-miR-3675-5p,hsa-miR-4634,hsa-miR-6792-3p,hsa-m iR-138-2-3p, hsa-miR-198, hsa-miR-128-1-5p, hsa-miR-4296, hsa-miR-3177-3p, hsa-miR-6734-5p, hsa-miR-6857-5p, hsa-miR-345-3p, hsa-miR-4260, hsa-miR-4639-3p, hsa-miR-6762-5p, hsa-miR-485-5p, hsa-miR-4255, hsa-miR-1229-5p, hsa-miR-1538, hsa-miR-3940-5p, hsa-miR-493-3 p,hsa-miR-4780,hsa-miR-668-5p,hsa-miR-3689d,hsa-miR-6753-5p,hsa-miR-1193,hsa-miR-4640-3p,hsa-miR-604,hsa-miR-4672,hsa-miR-664b-5p,hsa-miR-15b-3p,hsa-miR-1912-3p,hsa-miR-6883-5p,hsa-miR-3074-3p,hsa-miR-6807-5p,hsa-miR-1273h-5p,hsa-miR-5584-3p,hsa-m iR-3126-5p, hsa-miR-6810-5p, hsa-miR-3153, hsa-miR-3622b-5p, hsa-miR-1343-3p, hsa-miR-513a-5p, hsa-miR-585-3p, hsa-miR-563, hsa-miR-4436a, hsa-miR-3935, hsa-miR-6772-3p, hsa-miR-615-5p, hsa-miR-6803-5p, hsa-miR-1182, hsa-miR-6838-5p, hsa-miR-4259, hsa-miR-7846-3p,hsa-miR-670-5p,hsa-miR-551a,hsa-miR-6779-5p,hsa-miR-12121,hsa-miR-371b-3p,hsa-miR-6826-3p,hsa-miR-4709-5p,hsa-miR-4293,hsa-miR-6820-3p,hsa-miR-6827-5p,hsa-miR-4700-5p,hsa-miR-3663-3p,hsa-miR-25-3p,hsa-miR-2277-5p,hsa-miR-4325,hsa-miR-185-5p,hsa-m iR-1227-3p, hsa-let-7b-3p, hsa-miR-103a-1-5p, hsa-miR-6501-5p, hsa-miR-4502, hsa-miR-4322, hsa-miR-34c-3p, hsa-miR-6757-5p, hsa-miR-639, hsa-miR-421, hsa-miR-6860, hsa-miR-194-3p, hsa-miR-7704, hsa-miR-6751-5p, hsa-miR-8088, hsa-miR-769-5p, hsa-miR-3180, hsa-miR-3 651,hsa-miR-3189-3p,hsa-miR-6130,hsa-miR-3132,hsa-miR-6801-3p,hsa-miR-8063,hsa-miR-4664-3p,hsa-miR-4788,hsa-miR-6719-3p,hsa-miR-4288,hsa-miR-4691-5p,hsa-miR-6133,hsa-miR-3144-5p,hsa-miR-1304-5p,hsa-miR-6824-5p,hsa-miR-6822-5p,hsa-miR-7975,hsa-miR -449c-3p,hsa-miR-574-5p,hsa-miR-3173-3p,hsa-miR-371a-5p,hsa-miR-3663-5p,hsa-miR-3685,hsa-miR-11400,hsa-miR-4753-5p,hsa-miR-4721,hsa-miR-635,hsa-miR-6780a-5p,hsa-miR-1307-3p,hsa-miR-3127-5p,hsa-miR-12124,hsa-miR-6816-3p,hsa-miR-3198,hsa-miR-134-3p,hsa-miR-6754-5p,hsa-miR-8086,hsa-miR-4520-5p,hsa-miR-4708-5p,hsa-miR-2116-5p,hsa-miR-6503-3p,hsa-miR-1226-5p,hsa-miR-6782-3p,hsa-miR-541-5p,hsa-miR-6816-5p,hsa-miR-4252,hsa-miR-4295,hsa-miR-5001-5p,hsa-miR-550b-3p,hsa-miR-6754-3p,hsa-miR-6759-3p,hs a-miR-4717-3p,hsa-miR-4297,hsa-miR-4667-3p,hsa-miR-3191-3p,hsa-miR-6895-3p,hsa-miR-660-3p,hsa-miR-4276,hsa-miR-1202,hsa-miR-2113,hsa-miR-4737,hsa-miR-4529-5p,hsa-miR-4710,hsa-miR-7111-3p,hsa-miR-4732-5p,hsa-miR-3944-3p,hsa-miR-4711-3p,hsa-miR-2392, hsa-miR-5004-5p,hsa-miR-8073,hsa-miR-3925-5p,hsa-miR-4492,hsa-miR-7152-5p,hsa-miR-125a-3p,hsa-miR-4697-5p,hsa-miR-6857-3p,hsa-miR-6873-5p,hsa-miR-8052,hsa-miR-129-5p,hsa-miR-486-5p,hsa-miR-514b-5p,hsa-miR-449a,hsa-miR-3150a-3p,hsa-miR-8074,hsa-miR- 3616-3p,hsa-miR-4655-5p,hsa-miR-378g,hsa-miR-7977,hsa-miR-4476,hsa-miR-1284,hsa-miR-3944-5p,hsa-miR-3529-5p,hsa-miR-34b-3p,hsa-miR-1249-5p,hsa-miR-10527-5p,hsa-miR-766-3p,hsa-miR-6514-3p,hsa-miR-6718-5p,hsa-miR-12136,hsa-miR-3158-5p,hsa-miR-5006-3p,hsa-miR-4269,hsa-miR-3919,hsa-miR-138-1-3p,hsa-miR-200a-5p,hsa-miR-3156-5p,hsa-miR-4488,hsa-miR-4326,hsa-miR-12115,hsa-miR-4514,hsa-miR-7113-3p,hsa-miR-4253,hsa-miR-3147,hsa-miR-487b-5p,hsa-miR-410-5p,hsa-miR-6728-3p,hsa-miR-1909-5p,hsa-miR-6881-5p,hsa-miR-200b-5p,hsa-miR-1296-3p,hsa-miR-6817-5p,hsa-miR-7855-5p,hsa-miR-429,hsa-miR-637,hsa-miR-654-5p,hsa-miR-5195-3p,hsa-miR-6764-3p,hsa-let-7e-5p,hsa-miR-6789-3p,hsa-miR-4759,hsa-miR-9902,hsa-miR-3605-5p,hsa-miR-6872-5p,hsa-miR-877-3p,hsa-miR-6846-3p,hsa-miR-7845-5p,hsa-miR-3186-5p,hsa-miR-4485-5p,hsa-miR-378b,hsa-miR-938,hsa-miR-320e,hsa-miR-8087,hsa-miR-3918,hsa-miR-3960,hsa-miR-6509-5p,hsa-miR-1184,hsa-miR-6722-5p,hsa-miR-888-3p,hsa-miR-6511b-3p,hsa-miR-494-5p,hsa-miR-1267,hsa-miR-505-5p,hsa-miR-8060,hsa-miR-382-5p,hsa-miR-133b,hsa-miR-647,hsa-miR-6875-3p,hsa-miR-151b,hsa-miR-219a-2-3p,hsa-miR-7976,hsa-miR-1291,hsa-miR-3692-5p,hsa-miR-365b-5p,hsa-miR-5588-5p,hsa-miR-106b-5p,hsa-miR-3936,hsa-miR-12125,hsa-miR-4730,hsa-miR-548d-3p,hsa-miR-513b-5p,hsa-miR-612,hsa-miR-656-5p,hsa-miR-208a-5p,hsa-miR-8059,hsa-miR-6744-5p,hsa-miR-5699-5p,hsa-miR-892c-5p,hsa-miR-4660,hsa-miR-4443,hsa-miR-6858-5p,hs, a-miR-1269b,hsa-miR-4689,hsa-miR-431-3p,hsa-miR-744-5p,hsa-miR-6786-3p,hsa-miR-6716-5p,hsa-miR-187-3p,hsa-miR-758-5p,hsa-miR-10401-3p,hsa-miR-221-3p,hsa-miR-186-3p,hsa-miR-4740-5p,hsa-miR-6828-5p,hsa-miR-6868-5p,hsa-miR-6800-5p,hsa-miR-642b-5p,hsa- miR-214-5p, hsa-miR-629-3p, hsa-miR-10400-5p, hsa-miR-300, hsa-miR-6731-5p, hsa-miR-1251-3p, hsa-miR-6893-3p, hsa-miR-603, hsa-miR-8062, hsa-miR-1321, hsa-miR-488-5p, hsa-miR-4524b-3p, hsa-miR-6806-5p, hsa-miR-4731-5p, hsa-miR-6854-3p, hsa-miR-3130-3p, hsa-miR-362 2a-3p,hsa-miR-6506-5p,hsa-miR-1288-3p,hsa-miR-222-5p,hsa-miR-4319,hsa-miR-330-5p,hsa-miR-3150a-5p,hsa-miR-7109-3p,hsa-miR-67 45,hsa-miR-196b-3p,hsa-miR-3661,hsa-miR-10398-5p,hsa-miR-634,hsa-miR-646,hsa-miR-614,hsa-miR-7157-5p,hsa-miR-6787-3p,hsa-miR -192-5p,hsa-miR-450a-2-3p,hsa-miR-4635,hsa-miR-3064-3p,hsa-miR-3157-5p,hsa-miR-4756-5p,hsa-miR-578,hsa-miR-671-5p,hsa-miR-4684-5p,hsa-miR-6808-5p,hsa-miR-3650,hsa-miR-4652-5p,hsa-miR-6821-3p,hsa-miR-7155-3p,hsa-miR-6783-3p,hsa-miR-5188,hsa-miR-6072,hsa-miR-671-3p, hsa-miR-3975, hsa-miR-4697-3p, hsa-miR-1275, hsa-miR-7151-5p, hsa-miR-515-3p, hsa-miR-412-3p, hsa-miR-1228-5p, hsa-miR-6080, hsa-miR-4793-3p, hsa-miR-297, hsa-miR-3691-3p, hsa-miR-5571-3p, hsa-miR-320d, hsa-miR-4479, hsa-miR-891a-5p, hsa-miR-589-3p ,hsa-miR-4425,hsa-miR-3116,hsa-miR-4308,hsa-miR-4653-3p,hsa-miR-3120-5p,hsa-miR-661,hsa-miR-23b-3p,hsa-miR-4690-5p,hsa-miR-6851-5p,hsa-miR-6765-5p,hsa-miR-6840-5p,hsa-miR-6867-5p,hsa-miR-6715b-5p,hsa-miR-4494,hsa-miR-4462,hsa-miR-4677-5p,hsa-miR-615 -3p,hsa-miR-106b-3p,hsa-miR-192-3p,hsa-miR-134-5p,hsa-miR-542-5p,hsa-miR-4681,hsa-miR-885-5p,hsa-miR-181d-3p,hsa-miR-3928-5p,hsa-miR-6736-3p,hsa-miR-520d-3p,hsa-miR-6791-3p,hsa-miR-506-3p,hsa-miR-3202,hsa-miR-6504-5p,hsa-miR-4801-3p,hsa-miR-6851-3p, hsa-miR-4767,hsa-miR-10a-5p,hsa-miR-103b,hsa-miR-4752,hsa-miR-6804-5p,hsa-miR-1250-3p,hsa-miR-6883-3p,hsa-miR-377-5p,hsa-miR-12126,hsa-miR-423-5p,hsa-miR-5681b,hsa-miR-1231,hsa-miR-5195-5p,hsa-miR-935,hsa-miR-4712-5p,hsa-miR-6830-3p,hsa-miR-6891-5p,hsa-miR-5002-5p,hsa-miR-4438,hsa-miR-3677-3p,hsa-miR-1908-3p,hsa-miR-6742-3p,hsa-miR-4266,hsa-miR-4491,hsa-miR-3911,hsa-miR-1297,hsa-miR-4727-5p,hsa-miR-4436b-5p,hsa-miR-518c-5p,hsa-miR-1255b-2-3p,hsa-miR-4687-3p,hsa-miR-6739-3p,hsa-miR-6882-3p,hs a-miR-30c-1-3p, hsa-miR-328-5p, hsa-miR-3714, hsa-miR-21-3p, hsa-miR-4537, hsa-miR-3922-3p, hsa-miR-892c-3p, hsa-miR-1976, hsa-miR-584-3p, hsa-miR-3130-5p, hsa-miR-6865-3p, hsa-miR-29c-5p, hsa-miR-6890-3p, hsa-miR-27b-3p, hsa-miR-1257, hsa-miR-518f-3p, hsa-miR-318 8,hsa-miR-7843-5p,hsa-miR-4646-5p,hsa-miR-363-5p,hsa-miR-6833-3p,hsa-miR-4773,hsa-miR-3165,hsa-miR-127-5p,hsa-miR-223-3p,hsa-miR-2682-5p,hsa-miR-6509-3p,hsa-miR-369-5p,hsa-miR-6852-3p,hsa-miR-5001-3p,hsa-miR-146b-3p,hsa-miR-936,hsa-miR-6776-3p,hsa -miR-6715a-3p,hsa-miR-3160-3p,hsa-miR-6878-3p,hsa-miR-6513-5p,hsa-miR-3059-5p,hsa-miR-4709-3p,hsa-miR-4650-5p,hsa-miR-6774-5p,hsa-miR-6769a-3p,hsa-miR-770-5p,hsa-miR-5010-3p,hsa-miR-4698,hsa-miR-210-3p,hsa-miR-212-5p,hsa-miR-6819-5p,hsa-miR-675-5p,hsa-miR-1915-5p,hsa-miR-4307,hsa-miR-4763-5p,hsa-miR-6757-3p,hsa-miR-625-5p,hsa-miR-3189-5p,hsa-mi R-6088,hsa-miR-4423-5p,hsa-miR-4725-5p,hsa-miR-5704,hsa-miR-6809-3p,hsa-miR-4714-5p,hsa-miR-5580-3 p,hsa-miR-4999-5p,hsa-miR-558,hsa-miR-2278,hsa-miR-181a-2-3p,hsa-miR-29b-3p,hsa-miR-6499-3p,hsa-mi R-512-5p,hsa-miR-3126-3p,hsa-miR-6744-3p,hsa-miR-325,hsa-miR-487a-3p,hsa-miR-4518,hsa-miR-4739,hsa- miR-6077,hsa-miR-6740-3p,hsa-miR-1250-5p,hsa-miR-301a-5p,hsa-miR-8485,hsa-miR-1263,hsa-miR-4732-3p ,hsa-miR-3659,hsa-miR-147a,hsa-miR-6529-3p,hsa-miR-668-3p,hsa-miR-1266-5p,hsa-miR-3160-5p,hsa-miR- A urine extract containing at least one, two, three, four, five, six, seven, eight, nine, or ten or all of the microRNAs selected from the group consisting of miR-6882-5p, miR-943, miR-6850-3p, miR-30d-5p, miR-6853-5p, miR-676-5p, miR-6736-5p, and miR-29b-2-5p is provided. In the present disclosure, the urine extract may be an extract of urine from a kidney cancer patient. A single one of these microRNAs can predict whether a subject from which the urine is derived has kidney cancer, and a combination of five or more, ten or more, fifteen or more, or twenty or more can predict whether a subject from which the urine is derived has kidney cancer. Among these microRNAs, microRNAs that are highly expressed in kidney cancer patients are preferably used for prediction. ,

[0040] According to the present disclosure, hsa-miR-29a-3p, hsa-miR-30a-5p, hsa-miR-29b-3p, hsa-miR-196a-5p, hsa-miR-197-3p, hsa-miR-198, hsa-miR-199a-5p, hsa-miR-30d-5p, hsa-miR-10a-5p, hsa-miR-187-3p, hsa-miR-199b-5p, hsa-miR-214-3p, hsa-miR-223-3p, hsa-miR-133a-3p, hsa-miR-125a-5p, hsa-miR-134-5p, hsa-miR-149-5p, hsa-miR-184, hsa-miR-185-5p, hsa-miR-206, hsa-miR-200c-3p, hsa-miR-106b-5p, hsa-miR-29c-3p, hsa-miR-302a-3p, hsa-miR-299-3p, hsa-miR-296-5p, hsa-miR-130b-3p, hsa-miR-361-5p, hsa-miR-365a-3p, hsa-miR-365b-3p, hsa-miR-302c-5p, hsa-miR-370-3p, hsa-miR-373-5p, hsa-miR-373-3p, hsa-miR-378a-3p, hsa-miR-379-5p, hsa-miR-380-3p, hsa-miR-328-3p, hsa-miR-342-3p, hsa-miR-337-3p, hsa-miR-326, hsa-miR-133b, hsa-miR-325, hsa-miR-346, hsa-miR-20b-5p, hsa-miR-448, hsa-miR-429, hsa-miR-449a, hsa-miR-191-3p, hsa-miR-200a-5p, hsa-miR-409-3p, hsa-miR-483-3p, hsa-miR-484, hsa-miR-485-3p, hsa-miR-486-5p, hsa-miR-491-5p, hsa-miR-202-3p, hsa-miR-492, hsa-miR-494-3p, hsa-miR-512-5p, hsa-miR-498-5p, hsa-miR-520e-3p, hsa-miR-519c-5p, hsa-miR-523-5p, hsa-miR-518e-5p, hsa-miR-522-5p, hsa-miR-519a-5p,hsa-miR-519b-5p,hsa-miR-526b-5p,hsa-miR-525-5p,hsa-miR-518f-3p,hsa-miR-520b-3p,hsa-miR-518b,hsa-miR-526a-5p,hsa-miR-520c-5p ,hsa-miR-518d-5p,hsa-miR-520c-3p,hsa-miR-518c-5p,hsa-miR-520d-5p,hsa-miR-520d-3p,hsa-miR-516b-5p,hsa-miR-527,hsa-miR-518a-5 p,hsa-miR-519a-3p,hsa-miR-502-5p,hsa-miR-513a-5p,hsa-miR-557,hsa-miR-563,hsa-miR-564,hsa-miR-574-3p,hsa-miR-575,hsa-miR-578,hsa-miR-579-3p,hsa-miR-583,hsa-miR-585-3p,hsa-miR-588,hsa-miR-550a-3p,hsa-miR-595,hsa-miR-601,hsa-miR-608,hsa-miR-610,hsa-m iR-612,hsa-miR-615-3p,hsa-miR-617,hsa-miR-624-5p,hsa-miR-625-5p,hsa-miR-628-3p,hsa-miR-632,hsa-miR-634,hsa-miR-636,hsa-miR-637,hsa-miR-638,hsa-miR-639,hsa-miR-641,hsa-miR-650,hsa-miR-663a,hsa-miR-449b-5p,hsa-miR-654-5p,hsa-miR-657,hsa-miR-658,hsa- miR-542-5p, hsa-miR-671-5p, hsa-miR-668-3p, hsa-miR-767-3p, hsa-miR-769-5p, hsa-miR-769-3p, hsa-miR-766-3p, hsa-miR-765, hsa-miR-675-5p, hsa-miR-297, hsa-let-7b-3p, hsa-let-7d-3p, hsa-let-7f-1-3p, hsa-miR-25-5p, hsa-miR-26b-3p, hsa-miR-92a-2-5p, hsa-miR-29b-2-5p,hsa-miR-30c-2-3p, hsa-miR-139-3p, hsa-miR-181c-3p, hsa-miR-183-3p, hsa-miR-187-5p, hsa-miR-15b-3p, hsa-miR-124-5p, hsa-miR-125b-1-3p, hsa-miR-130a-5p, hsa-miR-135a-3p, hsa-miR-125a-3p, hsa-miR-127-5p, hsa-miR-149-3p, hsa-miR-150-3p, hsa-miR-185-3p, hsa-miR-186-3 p,hsa-miR-193a-5p,hsa-miR-194-3p,hsa-miR-30c-1-3p,hsa-miR-296-3p,hsa-miR-361-3p,hsa-miR-302d-5p,hsa-miR-371a-5p,hsa-miR-374a-3p,hsa-miR-377-5p,hsa-miR-342-5p,hsa-miR-423-5p,hsa-miR-424-3p,hsa-miR-18b-3p,hsa-miR-20b-3p,hsa-miR-431-3p,hsa-miR-483-5p, hsa-miR-486-3p, hsa-miR-193b-5p, hsa-miR-505-5p, hsa-miR-532-3p, hsa-miR-92b-5p, hsa-miR-551b-5p, hsa-miR-574-5p, hsa-miR-550a-5p, hsa-miR-615-5p, hsa-miR-616-3p, hsa-miR-625-3p, hsa-miR-629-5p, hsa-miR-298, hsa-miR-874-3p, hsa-miR-876-3p, hsa-miR-744-5p, hsa-miR -885-5p,hsa-miR-885-3p,hsa-miR-877-5p,hsa-miR-877-3p,hsa-miR-887-3p,hsa-miR-665,hsa-miR-760,hsa-miR-920,hsa-miR-921,hsa-miR-509-3-5p,hsa-miR-933,hsa-miR-936,hsa-miR-939-5p,hsa-miR-940,hsa-miR-1224-5p,hsa-miR-1224-3p,hsa-miR-1225-5p,hsa-miR-1225-3p,hsa-miR-1227-3p,hsa-miR-1228-5p,hsa-miR-1228-3p,hsa-miR-1229-3p,hsa-miR-1231,hsa-miR-1233-3p,hsa-miR-1234-3p,hsa-miR-1236-3p,hsa-miR-1237-3p,hsa-miR-1238-3p,hsa-miR-320b,hsa-miR-320c,hsa-miR-1323,hsa-miR-1301-3p,hsa-miR-1298-5p,hsa-miR-1181,hsa-mi R-1182,hsa-miR-1184,hsa-miR-1202,hsa-miR-1203,hsa-miR-663b,hsa-miR-1207-5p,hsa-miR-1207-3p,hsa-miR-1289,hsa-miR-1294,hsa-miR-1299,hsa-miR-1303,hsa-miR-1304-5p,hsa-miR-1249-3p,hsa-miR-1257,hsa-miR-1260a,hsa-miR-1263,hsa-miR-1267,hsa-miR-1268a,hsa-mi R-1270, hsa-miR-1275, hsa-miR-1281, hsa-miR-1292-5p, hsa-miR-664a-3p, hsa-miR-1307-3p, hsa-miR-320d, hsa-miR-1825, hsa-miR-675-3p, hsa-miR-1469, hsa-miR-1470, hsa-miR-1471, hsa-miR-1539, hsa-miR-1908-5p, hsa-miR-1909-5p, hsa-miR-1909-3p, hsa-miR-1910-5p, hsa-miR-19 12-3p,hsa-miR-1913,hsa-miR-1914-3p,hsa-miR-1915-3p,hsa-miR-365a-5p,hsa-miR-449b-3p,hsa-miR-2113,hsa-miR-1976,hsa-miR-2110,hsa-miR-151b,hsa-miR-762,hsa-miR-670-5p,hsa-miR-764,hsa-miR-2116-5p,hsa-miR-2116-3p,hsa-miR-548q,hsa-miR-2276-3p,hsa-miR-2278,hsa-miR-711, hsa-miR-718, hsa-miR-2681-3p, hsa-miR-2682-3p, hsa-miR-449c-3p, hsa-miR-2861, hsa-miR-3116, hsa-miR-3119, hsa-miR-3120-3p, hsa-miR-3122, hsa-miR-3124-5p, hsa-miR-3126-5p, hsa-miR-3130-5p, hsa-miR-3131, hsa-miR-3132, hsa-miR-3133, hsa-miR-466, hsa-miR-313 6-5p,hsa-miR-3138,hsa-miR-3141,hsa-miR-3144-5p,hsa-miR-1273c,hsa-miR-3147,hsa-miR-3150a-3p,hsa-miR-3151-5p,hsa-miR-3153,hsa-miR-3154,hsa-miR-3156-5p,hsa-miR-3157-5p,hsa-miR-3160-3p,hsa-miR-3161,hsa-miR-3162-5p,hsa-miR-3163,hsa-miR-3164,hsa-miR-3165,h sa-miR-1260b,hsa-miR-3169,hsa-miR-3173-3p,hsa-miR-1193,hsa-miR-3175,hsa-miR-3177-3p,hsa-miR-3178,hsa-miR-3179,hsa-miR-3180-5p,hsa-miR-3180-3p,hsa-miR-3184-5p,hsa-miR-3185,hsa-miR-3186-3p,hsa-miR-3188,hsa-miR-3189-3p,hsa-miR-3190-5p,hsa-miR-3191-3p,hs a-miR-3194-5p,hsa-miR-3195,hsa-miR-3196,hsa-miR-3197,hsa-miR-3198,hsa-miR-3199,hsa-miR-514b-5p,hsa-miR-3202,hsa-miR-4297,hsa-miR-4293,hsa-miR-4294,hsa-miR-4299,hsa-miR-4298,hsa-miR-4305,hsa-miR-4306,hsa-miR-4307,hsa-miR-4312,hsa-miR-4313,hsa-miR-4316,hsa-miR-4314,hsa-miR-4322,hsa-miR-4321,hsa-miR-4323,hsa-miR-4256,hsa-miR-4257,hsa-miR-4258,hsa-miR-4259,hsa-miR-4260,hsa-miR-4253,hsa-miR-4251,hsa-miR-432, 5,hsa-miR-4326,hsa-miR-4327,hsa-miR-4261,hsa-miR-4265,hsa-miR-4266,hsa-miR-2355-5p,hsa-miR-4268,hsa-miR-4269,hsa-miR-4271,hsa-miR-4276,hsa-miR-4274,hsa-miR-4281,hsa-miR-4279,hsa-miR-4278,hsa-miR-4285,hsa-miR-4283,hsa-miR-4284,hsa-miR-4286,hsa-miR-428 7,hsa-miR-4292,hsa-miR-4290,hsa-miR-4329,hsa-miR-3200-5p,hsa-miR-3605-3p,hsa-miR-3610,hsa-miR-3612,hsa-miR-3614-5p,hsa-miR-3616-3p,hsa-miR-3620-3p,hsa-miR-3621,hsa-miR-3622a-5p,hsa-miR-3622a-3p,hsa-miR-3622b-5p,hsa-miR-3648,hsa-miR-3649,hsa-miR-3652, hsa-miR-3660,hsa-miR-3663-5p,hsa-miR-3663-3p,hsa-miR-3665,hsa-miR-3667-5p,hsa-miR-3667-3p,hsa-miR-3675-3p,hsa-miR-3677-3p,hsa-miR-3679-5p,hsa-miR-3679-3p,hsa-miR-3689a-3p,hsa-miR-3691-5p,hsa-miR-3714,hsa-miR-3180,hsa-miR-3907,hsa-miR-3689b-3p,hsa-miR -3689c,hsa-miR-3909,hsa-miR-3911,hsa-miR-3917,hsa-miR-3919,hsa-miR-3150b-3p,hsa-miR-3925-5p,hsa-miR-3928-3p,hsa-miR-3935,hsa-miR-3936,hsa-miR-3937,hsa-miR-3941,hsa-miR-3942-5p,hsa-miR-3943,hsa-miR-3944-3p,hsa-miR-3945,hsa-miR-642b-3p,hsa-miR-550b-3p,hsa-miR-1268b,hsa-miR-548ab,hsa-miR-4421,hsa-miR-4428,hsa-miR-4429,hsa-miR-4430,hsa-miR-4433a-3p,hsa-miR-4439,hsa-miR-4440,hsa-miR-4441,hsa-miR-4443,hsa-miR-4444,hsa-miR-4446-3p,hsa-miR-4447,hsa-miR-4448,hsa-miR-4449,hsa-miR-4455,hsa-miR-4456,hsa -miR-4458,hsa-miR-4460,hsa-miR-378h,hsa-miR-3135b,hsa-miR-4462,hsa-miR-4463,hsa-miR-4465,hsa-miR-4466,hsa-miR-4467,hsa-miR-4468,hsa-miR-4470,hsa-miR-4472,hsa-miR-4474-3p,hsa-miR-4475,hsa-miR-4476,hsa-miR-4478,hsa-miR-3689d,hsa-miR-4481,hsa-miR-448 3,hsa-miR-4484,hsa-miR-4486,hsa-miR-4487,hsa-miR-4488,hsa-miR-4489,hsa-miR-4492,hsa-miR-4496,hsa-miR-4497,hsa-miR-4498,hsa-miR-4499,hsa-miR-4501,hsa-miR-4505,hsa-miR-4506,hsa-miR-2392,hsa-miR-4507,hsa-miR-4508,hsa-miR-4510,hsa-miR-4513,hsa-miR-45 16,hsa-miR-4518,hsa-miR-4521,hsa-miR-1269b,hsa-miR-4522,hsa-miR-4523,hsa-miR-4525,hsa-miR-4526,hsa-miR-4530,hsa-miR-4531,hsa-miR-4533,hsa-miR-4534,hsa-miR-4535,hsa-miR-1587,hsa-miR-4538,hsa-miR-4539,hsa-miR-3127-3p,hsa-miR-3156-3p,hsa-miR-3158-5p,hsa-miR-3162-3p,hsa-miR-3173-5p,hsa-miR-3187-5p,hsa-miR-3189-5p,hsa-miR-3619-3p,hsa-miR-3150b-5p,hsa-miR-3940-5p,hsa-miR-3960,hsa-miR-3972,hsa-miR-3978,hsa-miR-4634,hsa-miR-4638-5p,hsa-miR-4639-3p,hsa-miR-4640-5p,hsa-miR-4640-3p,hsa-miR-4642,hsa-miR- 4646-5p,hsa-miR-4646-3p,hsa-miR-4648,hsa-miR-4649-5p,hsa-miR-4649-3p,hsa-miR-4650-3p,hsa-miR-4651,hsa-miR-4652-5p,hsa-miR-4653-3p,hsa-miR-4654,hsa-miR-4655-5p,hsa-miR-4656,hsa-miR-4659b-3p,hsa-miR-4664-5p,hsa-miR-4664-3p,hsa-miR-4665-5p,hsa-miR-4665- 3p,hsa-miR-4667-5p,hsa-miR-4667-3p,hsa-miR-4669,hsa-miR-4672,hsa-miR-4673,hsa-miR-4674,hsa-miR-4675,hsa-miR-4677-5p,hsa-miR-4685-5p,hsa-miR-4685-3p,hsa-miR-4687-5p,hsa-miR-4687-3p,hsa-miR-1343-3p,hsa-miR-4688,hsa-miR-4689,hsa-miR-4690-5p,hsa-miR-4691 -5p,hsa-miR-4695-5p,hsa-miR-4695-3p,hsa-miR-4697-5p,hsa-miR-4697-3p,hsa-miR-4698,hsa-miR-4700-5p,hsa-miR-4700-3p,hsa-miR-4701-5p,hsa-miR-4701-3p,hsa-miR-4706,hsa-miR-4707-5p,hsa-miR-4707-3p,hsa-miR-4708-3p,hsa-miR-4709-3p,hsa-miR-4710,hsa-miR-4713-5p,hsa-miR-4714-5p, hsa-miR-4716-5p, hsa-miR-4716-3p, hsa-miR-4717-3p, hsa-miR-4720-5p, hsa-miR-4721, hsa-miR-4722-5p, hsa-miR-4722-3p, hsa-miR-4723-5p, hsa-miR-4723-3p, hsa-miR-4725-3p, hsa-miR-4726-5p, hsa-miR-4727-3p, hsa-miR-4728-5p, hsa-miR-4728-3p, hsa-miR-4729 ,hsa-miR-4730,hsa-miR-4731-5p,hsa-miR-4731-3p,hsa-miR-4732-5p,hsa-miR-4732-3p,hsa-miR-4734,hsa-miR-4736,hsa-miR-3064-5p,hsa-miR-3064-3p,hsa-miR-4738-3p,hsa-miR-4739,hsa-miR-4741,hsa-miR-4743-5p,hsa-miR-4745-5p,hsa-miR-4746-3p,hsa-miR-4747-5p,hsa-miR -4748,hsa-miR-4749-5p,hsa-miR-4749-3p,hsa-miR-4750-5p,hsa-miR-4751,hsa-miR-4752,hsa-miR-4753-5p,hsa-miR-371b-5p,hsa-miR-371b-3p,hsa-miR-4754,hsa-miR-4755-3p,hsa-miR-4756-5p,hsa-miR-4758-5p,hsa-miR-4758-3p,hsa-miR-4759,hsa-miR-4763-5p,hsa-miR-4763-3p ,hsa-miR-4764-5p,hsa-miR-4766-5p,hsa-miR-4769-5p,hsa-miR-4769-3p,hsa-miR-4776-5p,hsa-miR-4778-5p,hsa-miR-4779,hsa-miR-4780,hsa-miR-4436b-5p,hsa-miR-4781-5p,hsa-miR-4783-3p,hsa-miR-2467-3p,hsa-miR-4787-5p,hsa-miR-4787-3p,hsa-miR-4788,hsa-miR-4793-3p,hsa-miR-4800-5p,hsa-miR-4804-3p,hsa-miR-642a-3p,hsa-miR-4433a-5p,hsa-miR-4482-3p,hsa-miR-4999-5p,hsa-miR-5001-5p,hsa-miR-5002-3p,hsa-miR-5003-3p,hsa-miR-5006-5p,hsa-miR-5008-5p,hsa-miR-5009-3p,hsa-miR-5010-5p,hsa-miR-5010-3p,hsa-miR-5088-5p,hsa-mi R-5089-5p,hsa-miR-5090,hsa-miR-5188,hsa-miR-5189-5p,hsa-miR-5193,hsa-miR-5195-5p,hsa-miR-5195-3p,hsa-miR-5196-5p,hsa-miR-4524b-5p,hsa-miR-5100,hsa-miR-5572,hsa-miR-664b-5p,hsa-miR-664b-3p,hsa-miR-5581-5p,hsa-miR-5581-3p,hsa-miR-5584-5p,hsa-miR-548 au-3p,hsa-miR-5588-5p,hsa-miR-5589-5p,hsa-miR-5684,hsa-miR-5690,hsa-miR-5698,hsa-miR-5703,hsa-miR-5705,hsa-miR-197-5p,hsa-miR-204-3p,hsa-miR-211-3p,hsa-miR-301a-5p,hsa-miR-345-3p,hsa-miR-652-5p,hsa-miR-1185-2-3p,hsa-miR-873-3p,hsa-miR-1304-3p,hsa- miR-1247-3p, hsa-miR-1306-5p, hsa-miR-3184-3p, hsa-miR-3191-5p, hsa-miR-642b-5p, hsa-miR-365b-5p, hsa-miR-1185-1-3p, hsa-miR-98-3p, hsa-miR-381-5p, hsa-miR-503-3p, hsa-miR-937-5p, hsa-miR-939-3p, hsa-miR-1227-5p, hsa-miR-1229-5p, hsa-miR-1233-5p, hsa-miR-1236-5p,hsa-miR-1237-5p,hsa-miR-1238-5p,hsa-miR-1292-3p,hsa-miR-3617-3p,hsa-miR-3620-5p,hsa-miR-4632-5p,hsa-miR-4750-3p,hsa-miR-5739,hsa-miR-5787,hsa-miR-606, 8,hsa-miR-6069,hsa-miR-6071,hsa-miR-6072,hsa-miR-6074,hsa-miR-6075,hsa-miR-6076,hsa-miR-6077,hsa-miR-6085,hsa-miR-6086,hsa-miR-6088,hsa-miR-6089,hsa-miR-6090,hsa-miR-6124,hsa-miR-6125,hsa-miR-6126,hsa-miR-6127,hsa-miR-378j,hsa-miR-6130,hsa-miR-61 31,hsa-miR-6132,hsa-miR-6133,hsa-miR-6165,hsa-miR-6500-3p,hsa-miR-6501-3p,hsa-miR-6503-5p,hsa-miR-6506-5p,hsa-miR-6507-3p,hsa-miR-6508-5p,hsa-miR-6509-3p,hsa-miR-6510-5p,hsa-miR-6511a-5p,hsa-miR-6511a-3p,hsa-miR-6513-5p,hsa-miR-6514-3p,hsa-miR-651 5-5p,hsa-miR-6515-3p,hsa-miR-6715b-3p,hsa-miR-6716-5p,hsa-miR-6716-3p,hsa-miR-6717-5p,hsa-miR-6511b-5p,hsa-miR-6511b-3p,hsa-miR-6719-3p,hsa-miR-6721-5p,hsa-miR-6722-5p,hsa-miR-6722-3p,hsa-miR-6724-5p,hsa-miR-208a-5p,hsa-miR-210-5p,hsa-miR-128-1-5 p,hsa-miR-370-5p,hsa-miR-328-5p,hsa-miR-410-5p,hsa-miR-181d-3p,hsa-miR-520f-5p,hsa-miR-504-3p,hsa-miR-487b-5p,hsa-miR-585-5p,hsa-miR-597-3p,hsa-miR-598-5p,hsa-miR-605-3p,hsa-miR-619-5p,hsa-miR-1296-3p,hsa-miR-874-5p,hsa-miR-887-5p,hsa-miR-1250-3p,hsa-miR-1908-3p,hsa-miR-3151-3p,hsa-miR-3192-3p,hsa-miR-1343-5p,hsa-miR-5088-3p,hsa-miR-5189-3p,hsa-miR-5699-5p,hsa-miR-6726-5p,hsa-miR-6726-3p,hsa-miR-6727-5p,hsa-miR-6727-3p,hsa-miR-6728-5p,hsa-miR-6728-3p,hsa-miR-6729-5p,hsa-miR-6729-3p,hsa-miR -6730-5p,hsa-miR-6730-3p,hsa-miR-6731-5p,hsa-miR-6731-3p,hsa-miR-6732-5p,hsa-miR-6732-3p,hsa-miR-6734-5p,hsa-miR-6734-3p,hsa-miR-6735-5p,hsa-miR-6735-3p,hsa-miR-6736-5p,hsa-miR-6736-3p,hsa-miR-6737-5p,hsa-miR-6737-3p,hsa-miR-6738-5p,hsa-miR-6738-3 p,hsa-miR-6740-5p,hsa-miR-6740-3p,hsa-miR-6741-5p,hsa-miR-6741-3p,hsa-miR-6742-5p,hsa-miR-6742-3p,hsa-miR-6743-5p,hsa-miR-6743-3p,hsa-miR-6744-5p,hsa-miR-6744-3p,hsa-miR-6745,hsa-miR-6746-5p,hsa-miR-6747-5p,hsa-miR-6747-3p,hsa-miR-6748-5p,hsa-miR- 6748-3p,hsa-miR-6749-5p,hsa-miR-6749-3p,hsa-miR-6750-5p,hsa-miR-6750-3p,hsa-miR-6751-5p,hsa-miR-6752-5p,hsa-miR-6752-3p,hsa-miR-6753-5p,hsa-miR-6753-3p,hsa-miR-6754-5p,hsa-miR-6754-3p,hsa-miR-6755-5p,hsa-miR-6756-5p,hsa-miR-6756-3p,hsa-miR-6757-5p,hsa-miR-6757-3p, hsa-miR-6758-5p, hsa-miR-6759-5p, hsa-miR-6759-3p, hsa-miR-6760-5p, hsa-miR-6760-3p, hsa-miR-6761-3p, hsa-miR-6762-5p, hsa-miR-6762-3p, hsa-miR-6763-5p, hsa-miR-6763-3p, hsa-miR-6765-5p, hsa-miR-6766-5p, hsa-miR-6766-3p, hsa-miR-6767-5p, hsa-miR-6 768-5p,hsa-miR-6769a-5p,hsa-miR-6769a-3p,hsa-miR-6770-5p,hsa-miR-6771-5p,hsa-miR-6771-3p,hsa-miR-6772-5p,hsa-miR-6772-3p,hsa-miR-6773-3p,hsa-miR-6774-5p,hsa-miR-6775-5p,hsa-miR-6775-3p,hsa-miR-6776-5p,hsa-miR-6776-3p,hsa-miR-6777-5p,hsa-miR-6777-3p, hsa-miR-6778-5p,hsa-miR-6778-3p,hsa-miR-6779-5p,hsa-miR-6779-3p,hsa-miR-6780a-5p,hsa-miR-6780a-3p,hsa-miR-6781-5p,hsa-miR-6782-5p,hsa-miR-6782-3p,hsa-miR-6783-5p,hsa-miR-6783-3p,hsa-miR-6784-5p,hsa-miR-6784-3p,hsa-miR-6785-3p,hsa-miR-6786-5p,hsa-miR -6786-3p,hsa-miR-6787-5p,hsa-miR-6787-3p,hsa-miR-6788-5p,hsa-miR-6788-3p,hsa-miR-6789-5p,hsa-miR-6789-3p,hsa-miR-6790-5p,hsa-miR-6790-3p,hsa-miR-6791-5p,hsa-miR-6792-5p,hsa-miR-6792-3p,hsa-miR-6793-5p,hsa-miR-6793-3p,hsa-miR-6794-5p,hsa-miR-6794-3p,hsa-miR-6795-5p,hsa-miR-6795-3p,hsa-miR-6796-5p,hsa-miR-6796-3p,hsa-miR-6797-5p,hsa-miR-6797-3p,hsa-miR-6798-5p,hsa-m...

Claims

1. 1. A method for predicting the likelihood of a subject having lung cancer in a subject having or suspected of having lung cancer, comprising: A method comprising predicting the possibility that the subject has lung cancer using the expression level of let-7a-5p in a urinary extract obtained from the subject as an index.

2. In addition to let-7a-5p, (i) any microRNA listed in Table 3-1, Table 3-2, or Table 2; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Tables 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4 to 15 The method of claim 1, wherein when the expression level of any one or more microRNAs {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}, among one or more types of microRNAs selected from the group consisting of, is equal to or greater than a first threshold value set for each microRNA, it is indicated that the urine is likely derived from a lung cancer patient.

3. The method of claim 2, wherein when an expression level of one or more of the microRNAs in each table whose expression levels are increased in lung cancer patients is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient having lung cancer.

4. The method of claim 2 or 3, wherein the first threshold is equal to or lower than the third quartile value of the corresponding microRNA in healthy individuals.

5. In addition to let-7a-5p, miR-17-5p, miR-33a-5p, miR-95-3p, miR-9-5p, miR-155-5p, miR-496, miR-544a, mi R-556-5p, miR-577, miR-607, miR-19a-5p, miR-548c-5p, miR-548o-5p, miR-548am-5 p, miR-1278, miR-3117-3p, miR-3128, miR-3139, miR-3145-3p, miR-3201, miR-4282 , miR-548ad-3p, miR-548ag, miR-4471, miR-4678, miR-4699-5p, miR-4704-3p, miR-1 245b-5p, miR-5582-5p, miR-5582-3p, miR-5590-5p, miR-548aw, miR-5683, miR-580-5p, miR-1252-3p, miR-8058, and miR-548bb-5p. When the expression level of any one or more types of microRNAs {which may be one or more types, two or more types, three or more types, four or more types, five or more types, ten or more types, fifteen or more types, or twenty or more types of microRNAs} selected from the group consisting of microRNAs is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be possibly derived from a patient having lung cancer. The method according to any one of claims 2 to 4.

6. In addition to let-7a-5p, (i) any microRNA listed in Table 3-1, Table 3-2, or Table 2; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Tables 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4 to 15 The method according to claim 1, wherein, when the expression level of any one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} whose expression levels are decreased in lung cancer patients among one or more microRNAs selected from the group consisting of: is equal to or lower than a second threshold value set for each microRNA, it is indicated that the urine may be derived from a patient having lung cancer.

7. A method for predicting the likelihood that a subject will not have lung cancer in a subject suspected of having or likely to have lung cancer, comprising detecting let-7a-5p or In addition to let-7a-5p, among any of the microRNAs described in Table 2, Table 3-1, Table 3-2, and Tables 4-1 to 4-15, let-7c-5p, let-7d-5p, let-7f-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-21-5p, miR-24-1-5p, miR-26a-5p, miR-26b-5p, miR-31-5p, miR-96-5p, miR-98-5p, miR-99a-5p, miR-100-5p, miR-101-3p, miR-106a-5p, miR-148a-3p, miR-7-5p, miR-181c-5p, miR-182-3p, miR-216a-5p, miR-217-5p, miR-219a-5p, miR-222-3p, miR-1-3p, miR-130a-3p, miR-137-3p, miR-142-5p, miR-144-3p, miR-152-3p, miR-153-3p, miR-9-3p, miR-126-5p, miR-126-3p, miR-127-3p, miR-136-5p, miR-150-5p, miR-186-5p, miR-190a-5p, miR-200a-3p, miR-302a-5p, miR-30e-5p, miR-362-5p, miR-302b-5p, miR-302b-3p, miR-302c-3p, miR-302d-3p, miR-367-3p, miR-376c-3p, miR-369-3p, miR-376a-3p, miR-377-3p, miR-384, miR-409-5p, miR-410-3p, miR-376b-3p, miR-146b-5p, miR-520f-3p, miR-519c-3p, miR-523-3p, miR-518c-3p, miR-524-3p, miR-518d-3p, miR-499a-5p, miR-505-3p, miR-507, miR-508-3p, miR-514a-3p, miR-455-5p, miR-545-3p, miR-553, miR-559, miR-561-3p, miR-567, miR-568, miR-569, miR-570-3p, miR-573, miR-582-5p, miR-548a-3p, miR-586, miR-548b-3p, miR-590-5p, miR-592, miR-597-5p, miR-599,miR-606, miR-548c-3p, miR-618, miR-620, miR-621, miR-33b-5p, miR-633 、miR-648, miR-6511-5p, miR-411-5p, miR-655-3p, miR-60-5 p, miR-542-3p, miR-758-3p, miR-454-3p, miR-802, miR-19b-1-5p, miR-19 b-2-5p,miR-28-3p,miR-100-3p,miR-105-3p,miR-10d-3p,miR-10a-3p,mi R-10b-3p,miR-34a-3p,miR-196a-3p,miR-218-1-3p,miR- 221-5p,miR-27b-5p,miR-195-3p,miR-26a-2-3p,miR-367-5p,miR-374a-3 p, miR-340-5p, miR-135b-3p, miR-488-3p, miR-497-3p, miR-455-3p, miR- 545-5p,miR-556-3p,miR-576-3p,miR-548a-5p 、miR-628-5p,miR-548d-5p,miR-40b-3p,miR-890,miR-89-3p,miR-875 -5p,miR-876-5p,miR-708-3p,miR-190b-5p,miR-873-5p,miR-301b-3p,mi R-208b-3p,miR-922,miR-934,miR-944,miR-1185-5p,miR-1283,miR-117 9, miR-183, miR-1206, miR-548e-3p, miR-548j-5p, miR-548k, miR-1295a, miR-1302, miR-1305, miR-1244, miR-1245a, miR-1256, miR-1258, miR-126 1, 1262 ... 1277-3p,miR-548i,miR-1282,miR-1197,miR-1537-3p,miR-205-3p,miR-1 973, miR-2054, miR-759, miR-2115-3p, miR-3115, miR-3118, miR-3121-3p,miR-3123,miR-3129-5p,miR-3134,miR-3135a,miR-544b,miR-3140-3p,m iR-548t-5p,miR-3143,miR-548u,miR-3146,miR-3152-3p,miR-3159,miR -3167, miR-3171, miR-548w, miR-3183, miR-3065-5p, miR-4302, miR-4309 、miR-4263, miR-4277, miR-4291, miR-3606-5p, miR-3609, miR-3 611, miR-3613-5p, miR-3616-5p, miR-3618, miR-23c, miR-3658, miR-366 、miR-3664-5p, miR-368, miR-3671, miR-3672, miR-3674, miR-3683, miR-3 684, miR-3689a-5p, miR-3689b-5p, miR-3689e, miR-3912-3p, m iR-3914, miR-3920, miR-3923, miR-3927-3p, miR-3938, miR-548y, miR-393 9, miR-548h-3p, miR-4422, miR-548ac, miR-442, miR-4426, mi R-4427, miR-548ae-3p, miR-4445-5p, miR-4452, miR-4457, miR-4464, miR- 548ai, 70-5p, 548aj-3p, 77a, 77a, 77a, 7iR, 748ak, 7iR -4490,0000!miR-4503,-4504,-iR-4509,-iR-4517,-iR-4528,-iR -548an,miR-3117-5p,miR-3121-5p,miR-3124-3p,miR-3136-3p,miR-314 0-5p, miR-364-3p, miR-3688-5p, miR-3942-3p, miR-4474-5p, miR-3976, m iR-3977, miR-4636, miR-462a-5p, miR-462a-3p, miR-4659b-5p, miR-46 63, miR-4662b, miR-4666a-5p, miR-4666a-3p, miR-4668-3p, miR-219b-3p,miR-4677-3p, miR-4679, miR-4680-5p, miR-4680-3p, miR-4 683, miR-4693-5p, miR-4693-3p, miR-4696, miR-4699-3p, miR-4703-5p, mi R-4705, miR-203b-3p, miR-471-5p, miR-4714-3p, miR-4720-3p, miR-473 5-5p,miR-4742-5p,miR-4744,miR-499b-5p,miR-4757-5p,m iR-4757-3p,miR-4760-5p,miR-4760-3p,miR-4760-3p,miR-47 72-5p,!miR-4772-3p,!miR-4774-3p,!miR-4777- 3p, miR-4778-3p, miR-4782-5p, miR-4782-3p, miR-1245b-3p, miR-4789-5 p, miR-4789-3p, miR-4790-3p, miR-4795-5p, miR-4798-5p, miR-4798-5p, m iR-4799-3p,miR-4520-2-3p,miR-5047,miR-548ah-3p,miR-548ao-5p,mi R-548ap-5p,miR-548ap-3p,miR-5186,miR-5191,miR-5197-3p,miR-548aq -5p,miR-548aq-3p,miR-548ar-5p,miR-548ar-3p,miR-5583-5p,miR-558 3-3p,miR-5586-5p,miR-548au-5p,miR-5590-3p,miR-5591-5p,miR-548av -5p, miR-5682, miR-5692c, miR-5687, miR-5688, miR-5691, miR-5692a, mi R-5697, miR-5700, miR-5692b, miR-40a-1-3p, miR-506-5p, miR -539-3p,miR-561-5p,miR-1271-3p,miR-548g-5p,miR-548x-5p,miR-548 aj-5p,miR-1277-5p,miR-513c-3p,miR-1178-5p,miR-36-3p,miR-6079,miR-6128, miR-548ay-5p, miR-548az-5p, miR-548az-3p, miR-6502 -3p, miR-6508-3p, miR-95-5p, miR-215-3p, miR-153-5p, miR-190a -3p, miR-412-5p, miR-520g-5p, miR-510-3p, miR-653-3p, miR-670-3p, miR-548e-5p, miR-548f-5p, miR-513b-3p, miR-1537-5p, miR- 6733-5p, miR-6811-5p, miR-6828-3p, miR-6838-3p, miR-6844, miR-6854-5p, miR-6864-3p, miR-6866-5p, miR-7153-5p, miR-7153-3p , miR-7154-5p, miR-7159-3p, miR-7160-3p, miR-7161-3p, miR-7705, miR-6516-3p, miR-8053, miR-8056, miR-8061, miR-8066, miR-80 67, miR-8076, miR-181b-2-3p, miR-548ad-5p, miR-548ae-5p, miR-548bb-3p, miR-520e-5p, miR-549a-5p, miR-147b-5p, miR-9900, mi R-548bc, miR-10393-5p, miR-10393-3p, miR-10397-3p, miR-10399-5p, miR-10525-3p, miR-12123, miR-12129, miR-12130, and miR-12 132 is less than a first threshold value for a microRNA that is more highly expressed in lung cancer patients than in non-lung cancer patients, or is greater than or equal to a second threshold value for a microRNA that is less highly expressed in lung cancer patients than in non-lung cancer patients, indicating that the urine is likely to be derived from a patient without lung cancer.

8. A method for predicting the possibility that a subject has early-stage lung cancer in a subject having or suspected of having lung cancer, the method comprising predicting the possibility that the subject has early-stage lung cancer using the expression level of let-7a-5p in a urinary extract of the subject as an index, or using the expression of a microRNA listed in any one of Tables 22-1 and Tables 23-1 to 23-14 in addition to let-7a-5p as an index {each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}.

9. A method for predicting the possibility that a subject having or suspected of having lung cancer has early stage I lung cancer, the method comprising predicting the possibility that the subject has early stage lung cancer using the expression level of let-7a-5p in a urinary extract of the subject as an index, or using the expression of a microRNA listed in any one of Tables 22-1 to 22-13 in addition to let-7a-5p (which may independently be 1 or more types, 2 or more types, 3 or more types, 4 or more types, 5 or more types, 10 or more types, 15 or more types, or 20 or more types of microRNA in each table) as an index.

10. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, (i) any microRNA listed in Table 3-1, Table 3-2, or Table 2; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Tables 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4 to 15 one or more microRNAs selected from the group consisting of {in each table, each may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; The urine is from a subject having or suspected of having lung cancer. method.

11. 11. The method of claim 10, Specific microRNAs include let-7a-5p, as well as Below (ii) to (xiii): (ii) any microRNA with a p-value of less than 0.005 listed in Table 4-1; (iii) any microRNA having a p-value of less than 0.005 as set forth in Table 4-2; (iv) any microRNA having a p-value of less than 0.005 as set forth in Table 4-3; (v) any microRNA having a p-value of less than 0.005 as set forth in Table 4-4; (vi) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-5; (vii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-6; (viii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-7; (ix) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-8; (x) any microRNA listed in Tables 4-9 having a p-value of less than 0.005; (xi) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-10; (xii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-11; and (xiii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-12; (xiv) any microRNA having a p-value of less than 0.005 listed in Tables 4-13; (xv) any microRNA having a p-value of less than 0.005 listed in Tables 4-14; and (xvi) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-15 one or more microRNAs selected from the group consisting of {in each table, each may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; method.

12. The method for analyzing a urine sample according to claim 10 or 11, Specific microRNAs include let-7a-5p and (ii) A method in which the microRNA is any one of those listed in Table 4-1 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}.

13. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, (a) a microRNA described in any one of Tables 22-1 and 23-1 to 23-13 {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}; The urine is from a subject having or suspected of having lung cancer. method.

14. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {each of the tables may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; method.

15. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (a) a microRNA listed in any one of Tables 22-1 and 23-1 to 23-13 (which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table), wherein the microRNA has an accuracy of 70% or more.

16. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (a) a microRNA listed in any one of Tables 22-1 and 23-1 to 23-13 (which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table), wherein the microRNA has an accuracy of 80% or more.

17. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (a) a microRNA listed in any one of Tables 22-1 and 23-1 to 23-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 90% or more.

18. 15. A method for analyzing a urine sample according to claim 14, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 70% or more.

19. 15. A method for analyzing a urine sample according to claim 14, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 80% or more.

20. 15. A method for analyzing a urine sample according to claim 14, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 90% or more.

21. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; Extracting the microRNA captured on the nanowire; and To confirm whether a specific microRNA is included in the extracted microRNA This includes: The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); The method, wherein the urine is urine from a subject having or suspected of having lung cancer.

22. 22. The method of claim 21, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 70% or more in the table.

23. 22. The method of claim 21, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 80% or more in the table.

24. 22. The method of claim 21, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 90% or more in the table.

25. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or let-7a-5p,miR-134-5p,miR-346,miR-564,miR-574-3p,miR-575,mi R-632,miR-661,miR-663a,miR-658, miR-297,miR-139-3p,miR-149-3p,m iR-20b-3p,miR-431-3p,miR-550a-5 p,miR-885-5p,miR-936,miR-937-3p ,miR-943,miR-1228-5p,miR-1184,m iR-1204,miR-1538,miR-1909-5p,mi R-1910-5p,miR-1912-3p,miR-196b- 3p,miR-1972,miR-3153,miR-3162-5 p,miR-1193,miR-4260,miR-4253,mi R-4326,miR-4269,miR-4276,miR-36 22a-3p,miR-3646,miR-3652,miR-31 80,miR-550b-3p,miR-4428,miR-443 3a-3p,miR-4440,miR-4444,miR-444 7,miR-4449,miR-4455,miR-3155b,m iR-4483,miR-4498,miR-2392,miR-4 535,miR-4539,miR-3173-5p,miR-45 29-5p,miR-4638-5p,miR-4655-5p,m iR-4685-3p,miR-1343-3p,miR-4701 -3p,miR-4717-3p,miR-4725-5p,miR -4726-3p,miR-4732-5p,miR-4738-3 p,miR-4748,miR-4750-5p,miR-371b -5p,miR-4436b-5p,miR-4793-3p,mi R-5001-3p,miR-5002-3p,miR-5006- 5p,miR-5090,miR-5572,miR-5584-3 p,miR-5705,miR-1237-5p,miR-6072 ,miR-6131,miR-6503-3p,miR-6511b -5p,miR-1296-3p,miR-5189-3p,miR -6728-5p,miR-6729-5p,miR-6736-3 p,miR-6738-5p,miR-6738-3p,miR-6 740-3p,miR-6753-5p,miR-6754-3p,Selected from the group (ALL) consisting of miR-6756-5p, miR-6759-5p, miR-6765-5p, miR-6768-5p, miR-6772-3p, miR-6773-3p, miR-6787-3p, miR-6790-5p, miR-6792-5p, miR-6798-5p, miR-6804-3p, miR-6805-5p, miR-6809-3p, miR-6816-5p, miR-6820-5p, miR-6821-5p, miR-6821-3p, miR-6822-5p, miR-6830-3p, miR-6832-3p, miR-6833-5p, miR-6833-3p, miR-6834-5p, miR-6780b-3p, miR-6854-3p, miR-6862-5p, miR-6867-5p, miR-6868-3p, miR-6871-5p, miR-6875-3p, miR-6877-5p, miR-6878-3p, miR-6882-3p, miR-6883-5p, miR-6883-3p, miR-6893-3p, miR-6894-3p, miR-7109-3p, miR-7152-5p, miR-7160-5p, miR-7843-5p, miR-8059, miR-8077, miR-7977, miR-4485-5p, miR-8485, miR-9718, miR-10396a-5p, miR-10398-5p, miR-10396b-5p, and miR-11400, The urine is from a subject having or suspected of having lung cancer. method.

26. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, let-7e-5p, miR-23a-3p, miR-24-3p, miR-25-3p, miR-28-5p, miR-29a-3p, miR-30a-3p, miR-92a-3p, miR-29b-3p, miR-105-5p, miR-192-5p, miR-199a-5p, miR-129-5p, miR-30c-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-187-3p, miR-205-5p, miR-210-3p, miR-211-5p, miR-212-3p, miR-214-3p, miR-221-3p, miR-200b-3p, let-7i-5p, miR-15b-5p, miR-23b-3p, miR-27b-3p, miR-138-5p, miR-143-3p, miR-134-5p, miR-146a-5p, miR-154-5p, miR-184, miR-194-5p, miR-34b-5p, miR-34c-5p, miR-299-3p, miR-99b-5p, miR-296-5p, miR-361-5p, miR-370-3p, miR-371a-3p, miR-373-5p, miR-378a-3p, miR-381-3p, miR-382-5p, miR-340-3p, miR-330-3p, miR-328-3p, miR-342-3p, miR-323a-3p, miR-338-3p, miR-325, miR-346, miR-196b-5p, miR-422a, miR-449a, miR-200a-5p, miR-433-3p, miR-323b-5p, miR-484, miR-485-5p, miR-485-3p, miR-486-5p, miR-487a-3p, miR-488-5p, miR-489-3p, miR-491-5p, miR-511-5p, miR-202-3p, miR-492, miR-432-5p, miR-494-3p, miR-497-5p, miR-512-5p, miR-512-3p, miR-498-5p, miR-515-5p, miR-515-3p, miR-519e-3p, miR-520a-3p, miR-526b-5p, miR-525-5p, miR-525-3p, miR-517a-3p, miR-517b-3p, miR-519d-3p, miR-521miR-520d-3p,miR-520g-3p,miR-516b-3p,miR-516a-3p,miR-517c-3p,mi R-520h,miR-519a-3p,miR-500a-3p,miR-501-5p,miR-506- 3p,miR-509-3p,miR-510-5p,miR-299-5p,miR-18a-3p,miR-493-3p,miR- 487b-3p,miR-551a,miR-554,miR-92b-3p,miR-557,miR-558,miR-564,mi R-551b-3p,miR-572,miR-574-3p,miR-575,miR-579-3p,miR-584-5p,miR -589-3p,miR-550a-3p,miR-591,miR-593-5p,miR-595,miR-601,miR-602 ,miR-603,miR-604,miR-608,miR-609,miR-610,miR-612,miR-614,miR-6 15-3p,miR-616-5p,miR-617,miR-622,miR-623,miR-628-3p,miR-629-3p ,miR-631,miR-632,miR-634,miR-635,miR-636,miR-637,miR-638,miR-6 39,miR-642a-5p,miR-64a,miR-645,miR-649,miR-650,miR-61,miR-66 3a,miR-449b-5p,miR-654-5p,miR-657,miR-658,miR-542-5p,miR-363-� p,miR-671-5p,miR-668-3p,miR-454-5p,miR-769-3p,miR-7 66-3p,miR-765,miR-70-5p,miR-675-5p,miR-297,let-7d-3p,miR-15a- 3p,miR-16-1-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR -26b-3p,miR-92a-2-5p,miR-16-2-3p,miR-139-3p,miR-7-1-3p,miR-181 a-2-3p,miR-181c-3p,miR-183-3p,miR-187-5p,miR-214-5p,miR-222-5p,miR-200b-5p,miR-15b-3p,miR-30b-3p,miR-124-5p,miR-125b-1-3p,miR -135a-3p,miR-138-2-3p,miR-141-5p,miR-125a-3p,miR-125b-2-3p,miR- 138-1-3p,miR-149-3p,miR-185-3p,miR-186-3p,miR-193a-5p,miR-200c -5p,miR-194-3p,miR-106b-3p,miR-29c-5p,miR-219a-2-3p,miR-34b-3p, miR-34c-3p,miR-99b-3p,miR-296-3p,miR-130b-5p,miR-371a-5p,miR-3 77-5p,miR-330-5p,miR-342-5p,miR-323a-5p,miR-151a-5p,miR-338-5p, miR-339-3p,miR-335-3p,miR-424-3p,miR-18b-3p,miR-20b -3p,miR-431-3p,miR-483-5p,miR-486-3p,miR-146b-3p,miR-193b-5p,mi R-500a-5p,miR-505-5p,miR-508-5p,miR-532-3p,miR-92b-5p,miR-551b -5p,miR-574-5p,miR-589-5p,miR-550a-5p,miR-593-3p,miR-615-5p,miR -625-3p,miR-629-5p,miR-411-3p,miR-654-3p,miR-671-3p,miR-891a-� p,miR-300,miR-892a,miR-874-3p,miR-888-3p,miR-892b,miR-541-5p,mi R-541-3p,miR-875-3p,miR-708-5p,miR-147b-3p,miR-744- 3p,miR-885-5p,miR-885-3p,miR-877-3p,miR-887-3p,miR-6 65,miR-760,miR-920,miR-921,miR-935,miR-936,miR-937-3p,miR-938, miR-939-5p,miR-940,miR-1224-3p,miR-1225-5p,miR-1225-3p,miR-1226-5p,miR-1228-5p,miR-1228-3p,miR-1229-3p,mi R-1231,miR-1233-3p,miR-1234-3p,miR-1236-3p,miR-1237-3p,miR-1238 -3p,miR-513b-5p,miR-513c-5p,miR-320c,miR-1271-5p,miR-1298-5p,m iR-1178-3p,miR-1181,miR-1182,miR-1184,miR-1203,miR-120 4,miR-1207-5p,miR-1207-3p,miR-1285-3p,miR-1286,miR-1287-5p,miR -1291,miR-1293,miR-1294,miR-1297,miR-1303,miR-1304-5p,miR-1249- 3p,miR-1250-5p,miR-1260a,miR-1263,miR-1265,miR-1266-5p,miR-126 8a,miR-1269a,miR-1270,miR-1276,miR-1281,miR-1284,miR-1288-3p,mi R-1292-5p,miR-1306-3p,miR-1307-3p,miR-1322,miR-1322,miR-1825,m iR-1468-5p,miR-1469,miR-1471,miR-1538,miR-103b,miR-190 8-5p,miR-1909-5p,miR-1909-3p,miR-1910-5p,miR-19112- 3p,miR-1913,miR-1914-3p,miR-1915-3p,miR-103a-2-5p,m iR-224-3p,miR-365a-5p,miR-196b-3p,miR-49b-3p,miR-2113,miR-197 2,miR-1976,miR-2110,miR-151b,miR-49c-5p,miR-762,miR-761,miR-76 4,miR-548q,miR-2276-3p,miR-711,miR-2681-5p,miR-2682-5p, miR-2682-3p,miR-2861,miR-2909,miR-3122,miR-3124-5p,miR-3125,miR-3127-5p,miR-3130-5p,miR-378b,miR-466, miR-3137,miR-3138,miR-3141,miR-1273c,miR-3147,miR-314 8,miR-3150a-3p,miR-3151-5p,miR-3153,miR-3074-3p,miR-3154,miR-3 155a,miR-3158-3p,miR-3160-3p,miR-3162-5p,miR-3163,miR- 3165,miR-1260b,miR-3170,miR-3173-3p,miR-1193,miR-3174,miR-3175 ,miR-3176,miR-3178,miR-3180-3p,miR-3186-5p,miR-3186-3p ,miR-3187-3p,miR-3189-3p,miR-3191-3p,miR-3192-5p,miR- 3193,miR-3194-5p,miR-3195,miR-3196,miR-3197,miR-3198,miR-3199,m iR-3200-3p,miR-514b-3p,miR-3126-3p,miR-3065-3p,miR 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7,miR-3918,miR-3919,miR-3150b-3p,miR-3925-5p,miR-676-5p,miR-392 8-3p,miR-3929,miR-3934-5p,miR-3936,miR-3937,miR-3940-3p,miR-39 44-3p,miR-374c-5p,miR-642b-3p,miR-550b-3p,miR-1268b,miR-378e,m iR-4420,miR-4421,miR-378g,miR-4425,miR-4428,miR-4429,miR-4430, miR-4431,miR-4433a-3p,miR-4435,miR-4436a,miR-4437,miR-4438,miR- 4439,miR-4440,miR-4441,miR-4444445-3p,miR-4446-3p,miR-44 47,miR-4448,miR-449,miR-4450,miR-4451,miR-4453,miR-4454,miR-4 455,miR-4456,miR-4458,miR-3135b,miR-4462,miR-4463,miR-4465,miR -4466,miR-4467,miR-4470,miR-4472,miR-4473,miR-4474-3p,miR-4475,miR-4476,miR-4478,miR-3689d,miR-3689f,miR-4479,miR-3155b,miR-4 481,miR-4483,miR-4484,miR-4486,miR-4487,miR-4488,miR-4489,miR- 4491,miR-4492,miR-4494,miR-4496,miR-4497,miR-4498,miR-4502,miR -4505,miR-4506,miR-2392,miR-4507,miR-4508,miR-4510,miR-4511,mi R-4513,miR-4514,miR-4516,miR-4521,miR-4523,miR-4524a� 5p,miR-4526,miR-4527,miR-4529-3p,miR-4530,miR-4533,miR-378i,mi R-4535,miR-4537,miR-4538,miR-4539,miR-4540,miR-3120-� 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17-3p,miR-4718,miR-4721,miR-4722-5p,miR-4722-3p,miR-4723-3p,mi R-4724-5p,miR-4724-3p,miR-4725-3p,miR-4726-5p,miR- 4726-3p,miR-4727-3p,miR-4728-3p,miR-4731-5p,miR-4731- 3p,miR-4732-3p,miR-4732-3p,miR-473-3p,miR-4734mi R-4736,miR-4737,miR-3064-3p,miR-4738-3p,miR-4739,m iR-4740-5p,miR-4741,miR-4743-5p,miR-122b-3p,miR-4745-5p,miR-47 46-3p,miR-4747-5p,miR-4747-3p,miR-4748,miR-4749-5p,miR-4749-3p,miR-4750-5p,miR-4753-3p,miR-371b-3p,miR-4754,miR-4 755-3p,miR-4756-5p,miR-4756-3p,miR-4758-5p,miR-475 9,miR-4761-3p,miR-4763-3p,miR-4764-3p,miR-4766-5p, miR-4767,miR-4768-5p,miR-4768-3p,miR-4769-3p,miR-4 773,miR-4776-5p,miR-4776-3p,miR-4778-5p,miR-4780,miR-4436b-5p, miR-4436b-3p,miR-4783-3p,miR-4783-3p,miR-4785,miR-246 7-3p,miR-4786-3p,miR-4787-5p,miR-4787-3p,miR-4788, miR-4793-3p,miR-4794,miR-4796-5p,miR-4797-3p,miR-48 00-5p,miR-4800-3p,miR-4804-3p,miR-642a-3p,miR-550a-3p 5p,miR-4433a-5p,miR-4482-3p,miR-49999-3p,miR-5000-5 p,miR-5001-5p,miR-5001-3p,miR-5002-3p,miR-5004-5p, miR-5004-3p,miR-5006-5p,miR-5006-3p,miR-5007-5p,miR-5008-5p,mi R-5010-5p,miR-5088-5p,miR-5090,miR-5093,miR-5187-5p,m iR-5188,miR-5189-5p,miR-5190,miR-5192,miR-5194,miR-5196-5p,miR -5196-3p,miR-5197-5p,miR-4524b-3p,miR-5571-3p,miR -5100,miR-5572,miR-664b-3p,miR-5580-5p,miR-5580-3p,miR-5581-3p,miR-5584-3p,miR-5585-3p,miR-1295b-3p,miR-5588-5p, miR-5588-3p,miR-5589-5p,miR-5591-3p,miR-5684,miR-5685,miR-5681 b,miR-5690,miR-5694,miR-5696,miR-5698,miR-5702,miR-5703,miR-57 04,miR-5705,miR-5708,miR-197-5p,miR-204-3p,miR-211-3p,miR-212- 5p,miR-301a-5p,miR-345-3p,miR-584-3p,miR-60-3p,miR -1185-2-3p,miR-766-5p,miR-1285-5p,miR-1304-3p,miR- 1255b-2-3p,miR-1306-5p,miR-3184-3p,miR-3191-5p,miR -550b-2-5p,miR-365b-5p,miR-1185-1-3p,miR-3190-3p,miR-216a-3p,m iR-381-5p,miR-495-5p,miR-503-3p,miR-937-5p,miR-939-3p,miR-122 7-5p,miR-1229-5p,miR-1233-5p,miR-1236-5p,miR-1237-5p,miR-1238- 5p,miR-3617-3p,miR-3620-5p,miR-3927-5p,miR-3934-3p,miR-4632-5p ,miR-4743-3p,miR-5089-3p,miR-5739,miR-6068,miR-6069,m 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6779-3p,miR-6781-5p,miR-6781-3p,miR-6782-3p,miR-678 3-5p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786- 5p,miR-6786-3p,miR-6787-3p,miR-6788-5p,miR-6789-5p,miR-6789-3p,miR-6790-5p,miR-6791-5p,miR-6791-3p,miR-6792-5p,mi R-6792-3p,miR-6793-5p,miR-6794-5p,miR-6796-5p,miR- 6797-5p,miR-6797-3p,miR-6798-5p,miR-6798-3p,miR-6799-5p,miR-68 00-5p,miR-680-3p,miR-6801-3p,miR-6802-3p,miR-6803p 5p,miR-6803-3p,miR-6804-3p,miR-6805-5p,miR-6805-3p ,miR-6806-5p,miR-6807-5p,miR-6808-5p,miR-6809-3p,mi R-6810-5p,miR-6810-3p,miR-6812-5p,miR-6813-3p,miR- 6814-5p,miR-6815-3p,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-681 7-3p,miR-6818-3p,miR-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821- 5p,miR-6821-3p,miR-6822-5p,miR-6823-3p ,miR-6824-3p,miR-6825-5p,miR-6825-3p,miR-6826-3p,m iR-6827-5p,miR-6829-5p,miR-6829-3p,miR-6830-3p,miR- 6831-5p,miR-6832-3p,miR-6832-3p,miR-6833-30,miR-68 34-5p,miR-6780b-3p,miR-6780b-3p,miR-6836-3p,miR-683 7-5p,miR-6838-5p,miR-6839-5p,miR-6840-3p,miR-6842-5p,miR-6842- 3p,miR-6843-3p,miR-6845-3p,miR-6846-5p,miR-6846-3p,miR-6847-3p,miR-6848-5p,miR-6848-3p,miR-6849-5p,m iR-6849-3p,miR-6850-5p,miR-6850-3p,miR-6851-5p,miR -6852-3p,miR-6853-5p,miR-6854-3p,miR-6855-3p,miR-6 856-5p,miR-6856-3p,miR-6857-5p,miR-6858-5p,miR-685 9-5p,miR-6859-3p,miR-6769b-5p,miR-6860,miR-6861-3p ,miR-6862-3p,miR-6862-3p,miR-6863,miR-6867-5p,miR- 6867-3p,miR-6868-5p,miR-68689-5p,miR-68 70-3p,miR-6871-5p,miR-6873-5p,miR-6874-3p,miR-6875 -5p,miR-6876-5p,miR-6876-3p,miR-6877-5p,miR-6877-3 p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3p, miR-6881-5p,miR-6882-3p,miR-6883-3p,miR-6884-5p,mi R-6884-3p,miR-6885-3p,miR-6886-5p,miR-6886-3p,miR- 6888-5p,miR-6889-3p,miR-6890-5p,miR-6890-3p,miR-68 91-5p,miR-6891-3p,miR-6892-5p,miR-6892-3p,miR-6893 -3p,miR-6894-3p,miR-6895-5p,miR-6895-3p,miR-7106-� p,miR-7106-3p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-5p,miR-7109-3p,miR-7110-5p,miR-7111-3p,mi R-7112-5p,miR-7113-5p,miR-7113-3p,miR-7114-3p,miR- 7150,miR-7151-5p,miR-7151-3p,miR-7152-5p,miR-7154-3p,miR-7155- 5p,miR-7155-3p,miR-7156-5p,miR-7156-3p,miR-7158-5p,miR-7160- ,miR-7162-3p,miR-7515,miR-7702,miR-7704,miR-7706,miR-7843-5p,m iR-4433b-3p,miR-1273h-5p,miR-6516-5p,miR-7844-5p, miR-7845-5p,miR-7846-3p,miR-7848-3p,miR-7850-5p,mi R-7851-3p,miR-7854-3p,miR-7856-5p,miR-8052,miR-8055 ,miR-8057,miR-8059,miR-8060,miR-8062,miR-8063,miR-8064,miR-806 9,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,miR-8075,miR-80 77,miR-8078,miR-8079,miR-8080,miR-8082,miR-8083,miR-8 085,miR-8089,miR-128-2-5p,miR-7973,miR-7974,miR-7975,miR-7976,m iR-7977,miR-1249-5p,miR-4485-5p,miR-8485,miR-9500,miR-103a-1-5 p,miR-217-3p,miR-135a-2-3p,miR-375-5p,miR-498-3p,miR-9718,miR- 9899,miR-9902,miR-1843,miR-9986,miR-10392-3p,miR- 10394-5p,miR-10394-3p,miR-10395-5p,miR-10396a-3p,miR-10397-5p,miR-10398-5p,miR-10398-3p,miR-10400-3p,miR-1 0401-5p,miR-10401-3p,miR-10396b-3p,miR-10522-5p,miR-105, 23-5p, miR-10527-5p, miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-5p , miR-3059-3p, miR-3085-3p, miR-6529-5p, miR-6529-3p, miR-9851-5p, miR-12114, mi miR-12115, miR-12116, miR-12117, miR-12118, miR-12119, miR-12120, miR-12121, miR-12122, miR-12124, miR-12125, miR-12127, miR-12128, and miR-12131; The urine is from a subject having or suspected of having lung cancer. method.

27. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, let-7e-5p, miR-105-5p, miR-192-5p, miR-198, miR-129-5p, miR-187-3p, miR-210-3p, miR-212-3p, miR-214-3p, miR-200b-3p, miR-125b-5p, miR-138-5p, miR-134-5p, miR-184, miR-185-5p, miR-206, miR-106b-5p, miR-34c-5p, miR-99b-5p, miR-296-5p, miR-130b-3p, miR-302c-5p, miR-370-3p, miR-373-3p, miR-378a-3p, miR-382-5p, miR-340-3p, miR-342-3p, miR-337-3p, miR-323a-3p, miR-324-5p, miR-346, miR-422a, miR-425-3p, miR-369-5p, miR-323b-5p, miR-409-3p, miR-412-3p, miR-485-5p, miR-485-3p, miR-488-5p, miR-491-5p, miR-202-3p, miR-492, miR-432-3p, miR-494-3p, miR-512-5p, miR-512-3p, miR-498-5p, miR-520e-3p, miR-515-3p, miR-519c-5p, miR-523-5p, miR-518e-5p, miR-522-5p, miR-519a-5p, miR-519b-5p, miR-526b-5p, miR-525-5p, miR-518f-3p, miR-520b-3p, miR-526a-5p, miR-520c-5p, miR-518d-5p, miR-518c-5p, miR-519d-3p, miR-520d-5p, miR-516b-3p, miR-516a-3p, miR-501-5p, miR-513a-5p, miR-510-5p, miR-18a-3p, miR-551a, miR-92b-3p, miR-558, miR-564, miR-551b-3p, miR-572, miR-574-3p, miR-575, miR-583, miR-550a-3p, miR-595, miR-596, miR-601, miR-602, miR-604, miR-608, miR-610, miR-612, miR-614,miR-615-3p,miR-616-5p,miR-617,miR-622,miR-623,miR-629-3p,miR-6 32,miR-636,miR-637,miR-638,miR-639,miR-646,miR-650,miR-661,miR -663a,miR-654-5p,miR-657,miR-658,miR-421,miR-542-5p,miR-363-5p ,miR-668-3p,miR-769-3p,miR-766-3p,miR-770-5p,miR-297,let-7d-3p, miR-15a-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR-26b-3p,miR-92a-2 -5p,miR-30c-2-3p,miR-139-3p,miR-183-3p,miR-187-5p,miR-214-5p,m iR-200b-5p,miR-30b-3p,miR-130a-5p,miR-135a-3p,miR-138-2-3p,miR -125a-3p,miR-125b-2-3p,miR-138-1-3p,miR-149-3p,miR-150-3p,miR-� 85-3p,miR-186-3p,miR-193a-5p,miR-200c-5p,miR-155-3p,miR-194-3p ,miR-34b-3p,miR-34c-3p,miR-296-3p,miR-130b-5p,miR-361-3p,miR-3 02d-5p,miR-377-5p,miR-342-5p,miR-323a-5p,miR-338-5p,miR-424-3p ,miR-18b-3p,miR-20b-3p,miR-483-5p,miR-486-3p,miR-193 b-5p,miR-05-5p,miR-508-5p,miR-92b-5p,miR-51b-5p,miR-574-5p,m iR-550a-5p,miR-593-3p,miR-615-5p,miR-625-3p,miR-629-5p,miR-671- 3p,miR-891a-5p,miR-300,miR-892b,miR-541-3p,miR-744- 5p,miR-885-5p,miR-885-3p,miR-877-5p,miR-887-3p,miR-665,miR-760,miR-920,miR-921,miR-935,miR-936,miR-937-3p,miR-938,miR-939-5p, miR-940,miR-943,miR-1224-5p,miR-1224-3p,miR-1225-5 p,miR-1226-5p,miR-1228-5p,miR-1228-3p,miR-1233-3p,miR -1237-3p,miR-1238-3p,miR-513b-5p,miR-320c,miR-1271-5p, miR-1301-3p,miR-1298-5p,miR-1178-3p,miR-1182,miR-1184 ,miR-1203,miR-1204,miR-1207-5p,miR-1285-3p,miR-1293,miR-1303,m iR-1249-3p,miR-1250-5p,miR-548g-3p,miR-1266-5p,miR-1268a,miR-1 269a,miR-1270,miR-1276,miR-1292-5p,miR-1306-3p,miR-1307-3p,miR- 1321,miR-1468-5p,miR-1469,miR-1471,miR-153 8,miR-1908-5p,miR-1909-5p,miR-1909-3p,miR-1910-5p,miR-1912-3p, miR-1913,miR-1914-3p,miR-103a-2-5p,miR-365a-5p,miR -196b-3p,miR-449b-3p,miR-1972,miR-2110,miR-49c-5p,miR-762,miR- 670-5p,miR-761,miR-764,miR-2116-5p,miR-548q,miR-2276-3p,miR-22 77-3p,miR-711,miR-718,miR-2682-5p,miR-449c-3p,miR-3122,miR-312 4-5p,miR-3126-5p,miR-3130-30-5p,miR-3131,miR-3132,miR -3133,miR-466,miR-3137,miR-3138,miR-3141,miR-3147,miR-3150a-3p,miR-3151-5p,miR-3153,miR-3074-3p,miR-3155a,miR-3158-3p,miR-316 1,miR-3162-5p,miR-3163,miR-3164,miR-3160b,miR-3173-3p ,miR-1193,miR-3176,miR-3177-3p,miR-31780-3p,miR-3185,m iR-3186-3p,miR-3187-3p,miR-3189-3p,miR-3192-5p,miR -3195,miR-3196,miR-3197,miR-3198,miR-3199,miR-3202,miR-3126-3p ,miR-4296,miR-4297,miR-4299,miR-43004,miR-430 5,miR-4306,miR-4307,miR-4308,miR-4313,miR-4316,miR-4314,miR-43 19,miR-4317,miR-4322,miR-4321,miR-4323,miR-4257,miR-4 258,miR-4259,miR-4260,miR-4253,miR-4255,miR-4252,miR- 4326,miR-4327,miR-4261,miR-4265,miR-426,miR-4262,miR -4268,miR-4269,miR-4276,miR-4274,miR-4280,miR-4285,miR-4289,mi R-2277-5p,miR-3200-5p,miR-3605-3p,miR-3610,miR-361 2,miR-3614-5p,miR-3616-3p,miR-3619-5p,miR-3621,miR-3622a-5p,mi R-3622a-3p,miR-3622b-5p,miR-3646,miR-3648,miR-3650,miR-3651,mi R-3652,miR-3654,miR-36559,miR-360,miR-363-5p,miR-366 3-3p,miR-3665,miR-367-3p,miR-367-3p,miR-3677-3p,miR-3679-5p,miR-3679-3p,miR-3682-3p,miR-3685,miR-3689a-3p,miR- 3691-5p,miR-3713,miR-3714,miR-3180,miR-3689b-3p,miR-3689c,miR- 3917,miR-3918,miR-3150b-3p,miR-3925-5p,miR-3928-3p,miR-3934-5p ,miR-3935,miR-3936,miR-3937,miR-3944-3p,miR-3945,miR-550b-3p,mi R-1268b,miR-4421,miR-4428,miR-4429,miR-4430,miR-4431,miR-4433a -3p,miR-4435,miR-4436a,miR-4439,miR-4440,miR-4441,miR-4443,miR- 4444,miR-4446-3p,miR-4447,miR-4448,miR-449,miR-4450,miR-4451, miR-4453,miR-4454,miR-4456,miR-4458,miR-3135b,miR-4462 ,miR-4463,miR-4465,miR-4466,miR-4467,miR-4470,miR-4472,miR-447 4-3p,miR-4475,miR-4476,miR-3689d,miR-4479,miR-3155b,miR-4481,m iR-4483,miR-4484,miR-4485-3p,miR-4486,miR-4487,miR-4488,miR-44 89,miR-4492,miR-4496,miR-4497,miR-4498,miR-4499,miR-4502,miR-45 05,miR-4506,miR-2392,miR-4507,miR-4508,miR-4510,miR-4 513,miR-4514,miR-4515,miR-4516,miR-4525,miR-4 530,miR-4531,miR-4533,miR-4535,miR-1587,miR-4538,miR- 4539,miR-4540,miR-3120-5p,miR-3150a-5p,miR-3074-5p,miR-3156-3p,miR-3160-5p,miR-3162-3p,miR-3173-5p,miR-3619-3p,miR-3922-5p,m iR-3940-5p,miR-3944-5p,miR-4520-5p,miR-4529-5p,miR-3960,miR-4634,miR-4635, miR-4639-3p,miR-4640-5p,miR-4642,miR-4646-5p,miR-4 647,miR-4648,miR-4650-3p,miR-4651,miR-4652-5p,miR-4653-5p,miR- 4653-3p,miR-4654,miR-4655-5p,miR-4657,miR-4658,miR-4664-5p,miR -4664-3p,miR-4665-5p,miR-465-3p,miR-467-5p,miR-219b-5p,miR-46 69,miR-4670-5p,miR-4673,miR-4674,miR-4676-5p,miR-4681,miR-4682 ,miR-4684-5p,miR-4684-3p,miR-4685-3p,miR-4687-5p,miR-1343-3p,mi R-4688,miR-4690-5p,miR-4690-3p,miR-4691-5p,miR-4692,miR-4695-� p,miR-4700-5p,miR-4701-3p,miR-4707-5p,miR-4707-3p,miR- 4708-5p,miR-4708-3p,miR-203b-5p,miR-4710,miR-4714- 5p,miR-4716-3p,miR-4717-5p,miR-4717-3p,miR-4720-5p, miR-4722-3p,miR-4724-5p,miR-4725-5p,miR-4 726-3p,miR-4727-3p,miR-4728-5p,miR-4728-3p,miR-4730,miR-4731-3p ,miR-4732-3p,miR-4734,miR-47364-5p,miR-306 4-3p,miR-4740-5p,miR-4740-3p,miR-4741,miR-4743-5p,m iR-122b-3p,miR-4745-5p,miR-4746-3p,miR-4747-3p,miR -4748,miR-4749-5p,miR-4749-3p,miR-475p,miR-371b-5p,miR-4754,miR-4755-3p,miR-4758-5p,miR-4764-3p,miR-4767,miR- 4769-5p,miR-4776-5p,miR-4776-3p,miR-4780,miR-4436b-5p,miR-4436 b-3p,miR-4781-5p,miR-4783-3p,miR-4783-3p,miR-4785,miR-2467-3p, miR-4786-5p,miR-4786-3p,miR-4786-3p,miR-4793-3p,miR-4800-5p,mi R-4800-3p,miR-4801,miR-4804-3p,miR-550a-3-5p,miR- 4482-3p,miR-4999-5p,miR-5001-5p,miR-5002-3p,miR-50 04-5p,miR-5004-3p,miR-5006-5p,miR-5009-3p,miR-5010-5p,miR-5088 -5p,miR-5090,miR-5093,miR-5187-5p,miR-5188,miR-5189-5p,miR-519 0,miR-5193,miR-5195-5p,miR-5196-5p,miR-571-3p,miR-5100,miR-5 572,miR-664b-3p,miR-5580-3p,miR-5581-3p,miR-5584-3 p,miR-5585-3p,miR-5587-5p,miR-5588-5p,miR-5589-5p, miR-5685,miR-5681b,miR-5698,miR-5703,miR-5705,miR-197-5p,miR-2 04-3p,miR-211-3p,miR-301a-5p,miR-345-3p,miR-584-3p,miR-659-5p, miR-1185-2-3p,miR-766-5p,miR-873-3p,miR-1285-5p,miR-1247-3p,mi R-1255b-2-3p,miR-3191-5p,miR-64 2b-5p,miR-550b-2-5p,miR-365b-5p ,miR-1185-1-3p,miR-3190-3p,miR-937-5p,miR-1227-5p,miR-1236-5p,miR-1237-5p,miR-1238-5p,miR-1292-3p,miR-3617-3p,mi R-3934-3p,miR-4632-5p,miR-4750-3p,miR-5739,miR-5787,miR-6068,mi R-6070,miR-6071,miR-6072,miR-6074,miR-6075,miR-6076,miR-6080,m iR-6081,miR-6083,miR-6084,miR-6085,miR-6089,miR-6090,m iR-6124,miR-6125,miR-6126,miR-6127,miR-6129,miR-6130,miR-6131, miR-6132,miR-6133,miR-6134,miR-616500-5p,miR-6500-3p,miR -6501-5p,miR-6501-3p,miR-6503-3p,miR-6504-3p,miR-6508-5p,miR-6 509-3p,miR-6511a-5p,miR-6512-3p,miR-6513-5p,miR-6514-5p,miR-651 4-3p,miR-6515-5p,miR-6515-3p,miR-6716-3p,miR-6717 -5p,miR-6511b-5p,miR-6718-5p,miR-6721-5p,miR-6722-5p,miR-6722-3 p,miR-6724-5p,miR-210-5p,miR-128-1-5p,miR-134-3p,mi R-487a-5p,miR-489-5p,miR-504-3p,miR-487b-5p,miR-585-5p,miR-605� 3p,miR-619-5p,miR-656-5p,miR-668-5p,miR-1296-3p,miR-1301-5p,mi R-1298-3p,miR-874-5p,miR-1180-5p,miR-548j-3p,miR-125 0-3p,miR-1266-3p,miR-1288-5p,miR-1908-3p,miR-3192- 3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,miR-5088-3p,miR-5189-3p,miR-6720-5p,miR-6726-5p,miR-6728-5p,miR-6728-3p,mi R-6729-5p,miR-6729-3p,miR-6730-3p,miR-6731-5p,miR- 6731-3p,miR-6732-5p,miR-6734-5p,miR-6736-5p,miR-67 36-3p,miR-6737-5p,miR-6738-3p,miR-6740-5p,miR-6740- 3p,miR-6741-5p,miR-6742-5p,miR-6743-5p,miR-6746-5p,mi R-6747-5p,miR-6748-5p,miR-6749-5p,miR-6751-5p,miR- 6752-5p,miR-6752-3p,miR-6753-5p,miR-6753-3p,miR-67 56-5p,miR-6759-5p,miR-6760-5p,miR-6760-3p,miR-6761- 5p,miR-6762-5p,miR-6762-3p,miR-6763-5p,miR-6763-3p ,miR-6765-5p,miR-6765-3p,miR-6766-5p,m iR-6768-5p,miR-6769a-5p,miR-6770-5p,miR-6770-3p,miR-6772-5p,mi R-6772-3p,miR-6774-3p,miR-6776-5p,miR-6776-3p,miR-6 777-5p,miR-677-3p,miR-6778-5p,miR-6778-3p,miR-679-3p,miR-678 0a-5p,miR-6780a-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-678 3-5p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786- 5p,miR-6787-3p,miR-6788-5p,miR-6789-5p,miR-6789-3p,miR-6790-5p,miR-6791-3p,miR-6792-5p,miR-6792-3p,mi R-6793-5p,miR-6794-5p,miR-6795-5p,miR-6795-3p,miR-6796-5p,miR- 6796-3p,miR-6797-5p,miR-6798-5p,miR-6798-3p,miR-6800-5p,miR-68 00-3p,miR-6803-3p,miR-6804-3p,miR-6805-5p,miR-6805p 3p,miR-6806-5p,miR-6808-5p,miR-6809-3p,miR-6810-5p ,miR-6810-3p,miR-6812-5p,miR-6813-3p,miR-6814-5p,mi R-6815-5p,miR-6816-3p,miR-6817-5p,miR-6819-3p,miR- 6820-5p,miR-6820-3p,miR-6821-3p,miR-682 3-5p,miR-6824-5p,miR-6825-5p,miR-6827-5p,miR-6829-5p,miR-6829- 3p,miR-6830-5p,miR-6830-3p,miR-6832-5p,miR-6832-3p ,miR-6833-5p,miR-683-3p,miR-6834-5p,miR-6780b-3p ,miR-6836-3p,miR-6837-5p,miR-6837-3p,mi R-6839-5p,miR-6840-3p,miR-6842-5p,miR-6843-3p,miR- 6845-3p,miR-6846-5p,miR-6847-3p,miR-6848-5p,miR-684 9-5p,miR-6849-3p,miR-6850-5p,miR-6850-3p,miR-6852-5p,miR-6852- 3p,miR-6855-5p,miR-6855-3p,miR-6856-5p,miR-6856-3p,miR-6857-5p,miR-6859-5p,miR-6859-3p,miR-6769b-5p,miR-6860,miR-6861-5p ,miR-6862-5p,miR-6867-3p,miR-6868-3p,miR-6869-5p,miR-6870, -5p,miR-6871-5p,miR-6872-5p,miR-6873-5p,miR-6874-5p,miR-6875-� p,miR-6875-3p,miR-6876-5p,miR-6877-3p,miR-6878-3p,m iR-6879-5p,miR-6879-3p,miR-6880-5p,miR -6882-3p,miR-6883-3p,miR-6883-3p,miR-6887-5p,miR-68 87-3p,miR-6889-5p,miR-6891-3p,miR-6892-5p,miR-6892 -3p,miR-6893-3p,miR-6894-3p,miR-6895-5p ,miR-7106-5p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-3p,m iR-7110-5p,miR-711-5p,miR-7112-5p,miR-7113-5p,miR-7114-5p,miR- 7114-3p,miR-7150,miR-7151-3p,miR-7152-5p,miR-7154-3p,miR-7155- 5p,miR-7156-3p,miR-7160-5p,miR-7162-3p,miR-7515,miR-7702,miR-77 04,miR-7843-5p,miR-4433b-3p,miR-1273h-5p,miR-6516 -5p,miR-7845-5p,miR-7846-3p,miR-7851-3p,miR-7855-5p ,miR-7856-5p,miR-8052,miR-8057,miR-8059,miR-8060,miR-8063,miR- 8064,miR-8069,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,miR- 8075,miR-8077,miR-8079,miR-8082,miR-8085,miR-8087,miR -80889,miR-7974,miR-7975,miR-7976,miR-7977,miR-4485-5p,Selected from the group (Hemo) consisting of miR-8485, miR-103a-1-5p, miR-196a-1-3p, miR-217-3p, miR-135a-2-3p, miR-9718, miR-9898, miR-9902, miR-1843, miR-10226, miR-10392-5p, miR-10392-3p, miR-10394-3p, miR-10395-5p, miR-10396a-5p, miR-10396a-3p, miR-10398-5p, miR-10398-3p, miR-10400-5p, miR-10400-3p, miR-10401-5p, miR-10401-3p, miR-10396b-5p, miR-10396b-3p, miR-10522-5p, miR-10526-3p, miR-10527-5p, miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-3p, miR-3085-5p, miR-3085-3p, miR-6529-5p, miR-9851-5p, miR-12114, miR-12115, miR-12116, miR-12118, miR-12119, miR-12120, miR-12122, miR-12124, miR-12126, miR-12127, and miR-12128, The urine is from a subject having or suspected of having lung cancer. method.

28. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the specific microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, let-7b-5p, miR-25-3p, miR-28-5p, miR-29a-3p, miR-29b-3p, miR-105-5p, miR-192-5p, miR-196a-5p, miR-197-3p, miR-198, miR-199a-5p, miR-129-5p, miR-30d-5p, miR-147a, miR-10a-5p, miR-34a-5p, miR-181a-5p, miR-181b-5p, miR-187-3p, miR-199b-5p, miR-204-5p, miR-210-3p, miR-211-5p, miR-212-3p, miR-214-3p, miR-221-3p, miR-223-3p, miR-200b-3p, miR-23b-3p, miR-30b-5p, miR-122-5p, miR-124-3p, miR-125b-5p, miR-138-5p, miR-125a-5p, miR-134-5p, miR-149-5p, miR-184, miR-185-5p, miR-194-5p, miR-206, miR-106b-5p, miR-34c-5p, miR-299-3p, miR-99b-5p, miR-296-5p, miR-130b-3p, miR-365a-3p, miR-365b-3p, miR-302c-5p, miR-370-3p, miR-373-5p, miR-373-3p, miR-378a-3p, miR-380-3p, miR-382-5p, miR-340-3p, miR-330-3p, miR-328-3p, miR-342-3p, miR-337-3p, miR-324-5p, miR-324-3p, miR-338-3p, miR-133b, miR-325, miR-346, miR-196b-5p, miR-422a, miR-425-3p, miR-448, miR-449a, miR-191-3p, miR-200a-5p, miR-369-5p, miR-433-3p, miR-323b-5p, miR-409-3p, miR-412-3p, miR-483-3p, miR-484, miR-485-5p, miR-485-3p, miR-486-5p, miR-488-5p, miR-489-3p, miR-491-5p, miR-202-3p, miR-492, miR-432-3p, miR-494-3p,miR-497-5p,miR-512-5p,miR-498-5p,miR-515-5p,miR-519c-5p,miR-52 3-5p,miR-518e-5p,miR-522-5p,miR-519a-5p,miR-519b-5p,miR-526b-5p ,miR-525-5p,miR-525-3p,miR-518b,miR-518c-5p,miR-519d-3p,miR-52 0d-3p,miR-520g-3p,miR-516b-3p,miR-516b-3p,miR-516a-3p,miR-518a- 3p,miR-502-5p,miR-504-5p,miR-513a-5p,miR-506-3p,miR-510-5p,miR -532-5p,miR-299-5p,miR-18a-3p,miR-487b-3p,miR-551am iR-54,miR-92b-3p,miR-557,miR-558,miR-563,miR-564,miR-551b-3p, miR-572,miR-574-3p,miR-575,miR-579-3p,miR-580-3p,miR-583,miR-58 4-5p,miR-585-3p,miR-588,miR-589-3p,miR-550a-3p,miR-595,miR-601 ,miR-603,miR-604,miR-605-5p,miR-608,miR-610,miR-612,miR-614,miR -615-3p,miR-61-5p,miR-617,miR-622,miR-628-3p,miR-629-3p,miR-6 32,miR-634,miR-635,miR-636,miR-637,miR-638,miR-639,miR-642a-5p, miR-644a,miR-650,miR-548d-3p,miR-661,miR-663a,miR-449b-5p,miR- 654-5p,miR-657,miR-658,miR-421,miR-542-5p,miR-671-5p,miR-668-3p ,miR-767-3p,miR-454-5p,miR-769-5p,miR-769-3p,miR-76 5,miR-770-5p,miR-297,let-7b-3p, let-7d-3p,let-7f-1-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR-26b-3p,miR-92a-2-5p,miR-29b-2-5p,miR- 106a-3p,miR-16-2-3p,miR-192-3p,miR-129-1-3p,miR-139-3p,miR-183 -3p,miR-187-5p,miR-214-5p,miR-222-5p,miR-200b-5p,miR-15b-3p,mi R-30b-3p,miR-124-5p,miR-125b-1-3p,miR-135a-3p,miR-138-2-3p,miR -140-3p,miR-125a-3p,miR-125b-2-3p,miR-127-5p,miR-129-2-3p,miR- 138-1-3p,miR-149-3p,miR-150-3p,miR-185-3p,miR-186-3p,miR-193a- 5p,miR-200c-5p,miR-194-3p,miR-30c-1-3p,miR-219a-2-3p,miR-34b-3 p,miR-34c-3p,miR-99b-3p,miR-296-3p,miR-130b-5p,miR-361-3p,miR- 302d-5p,miR-371a-5p,miR-30-5p,miR-342-5p,miR-323a-5p,miR-15a -5p,miR-338-5p,miR-424-3p,miR-18b-3p,miR-20b-3p,miR -431-3p,miR-483-5p,miR-486-3p,miR-490-5p,miR-146b-3p,miR-193b- 5p,miR-516a-5p,miR-505-5p,miR-508-5p,miR-532-3p,miR-92b-5p,miR -551b-5p,miR-574-5p,miR-50a-5p,miR-593-3p,miR-615-5p,miR-625� 3p,miR-629-5p,miR-654-3p,miR-671-3p,miR-891a-5p,miR-300,miR-87 4-3p,miR-888-3p,miR-892b,miR-541-5p,miR-541-3p,miR-876-3p,miR- 708-5p,miR-147b-3p,miR-744-5p,miR-885-5p,miR-885-3p,miR-877-5p,miR-877-3p,miR-887-3p,miR-665,miR-760,miR-920,miR- 921,miR-933,miR-935,miR-936,miR-937-3p,miR-938,miR-939-5p,miR- 940,miR-943,miR-1224-5p,miR-1224-3p,miR-1225-3p,mi R-1226-3p,miR-1226-3p,miR-1227-3p,miR-1228-5p,miR-1228-3p,miR- 1229-3p,miR-1231,miR-123-3p,miR-1234-3p,miR-1236-3p,miR-1237- 3p,miR-1238-3p,miR-513b-5p,miR-513c-5p,miR-320b,miR-320c,miR-1 271-5p,miR-1301-3p,miR-1298-5p,miR-1178-3p,miR-1182,m iR-1184,miR-1202,miR-1203,miR-1204,miR-1207-5p,miR-1207-3p,miR -1285-3p,miR-1286,miR-1287-5p,miR-12893,miR-1294,miR- 1303,miR-1304-5p,miR-1249-3p,miR-1250-5p,miR-1257,miR-1260a,mi R-548g-3p,miR-1263,miR-1266-5p,miR-1267,miR-1268a,miR-1269a,mi R-1270,miR-1275,miR-1276,miR-1281,miR-1284,miR-1288-3p,miR-129 2-5p,miR-1255b-5p,miR-664a-3p,miR-1306-3p,miR-1307-3p,miR-1321 ,miR-1322,miR-320d,miR-1825,miR-1468-5p,miR-675-3p,miR-1469,mi R-1470,miR-1471,miR-1538,miR-1539,miR-103b,miR-1908-5p,miR-190 9-5p,miR-1909-3p,miR-1910-5p,miR-1912-3p,miR-1913,miR-1914-3p,miR-1915-3p,miR-103a-2-5p,miR-365a-5p,miR-196b-3p,miR-49b-3p, miR-2113,miR-1972,miR-1976,miR-2110,let-7a-2-3p,miR-151b,miR-76 2,miR-670-5p,miR-761,miR-764,miR-2115-5p,miR-2116- 3p,miR-548q,miR-2276-3p,miR-2277-3p,miR-2278,miR-711,mi R-2681-3p,miR-2682-5p,miR-2682-3p,miR-49c-3p,miR-2909,miR-31� 6,miR-3119,miR-3120-3p,miR-3122,miR-3124-5p,miR-3125,miR-3126-� p,miR-3127-5p,miR-3130-3p,miR-3130-5p,miR-3132,miR-31 33,miR-466,miR-3136-5p,miR-3137,miR-3138,miR-3141,miR-3144-5p,m iR-1273c,miR-3147,miR-3148,miR-3149,miR-3151-5p,m iR-3153,miR-3074-3p,miR-3154,miR-3155a,miR-3156-5p,miR-3157-�p, miR-3158-3p,miR-3160-3p,miR-3162-5p,miR-3163,miR-3165 ,miR-1260b,miR-3173-3p,miR-1193,miR-3176,miR-3177-3p,m iR-3178,miR-3179,miR-3180-3p,miR-3185,miR-3186-5p, miR-3186-3p,miR-3187-3p,miR-3188,miR-3189-3p,miR-320e,miR-3190- 5p,miR-3191-3p,miR-3192-5p,miR-3195,miR-3196,miR-3197,miR-3198, miR-3199,miR-3200-3p,miR-3202,miR-3126-3p,miR-4295,miR-4296,miR-4297,miR-4293,miR-4294,miR-4301,miR-4299,miR-4298,miR-430 0,miR-4304,miR-4303,miR-4305,miR-4306,miR-4307,miR-4308,miR-4311,miR-4, 312,miR-4313,miR-4316,miR-4314319,miR-4317,miR-4322,miR- 4321,miR-4323,miR-4324,miR-4256,miR-4257,miR-4258,miR-4259,miR- 4260,miR-4253,miR-4251,miR-4254,miR-4252,miR-4326,miR -4327,miR-4261,miR-4265,miR-4262,miR-2355-5p,miR-4268, miR-4269,miR-4271,miR-4276,miR-4274,miR-4279,miR-4278,miR-4280 ,miR-4285,miR-4283,miR-4284,miR-4286,miR-4288,miR-4292,miR-4289 ,miR-43290,miR-4329,miR-2277-5p,miR-3605-3p,miR-361 0,miR-3612,miR-3614-5p,miR-3615,miR-3616-3p,miR-3619-5p,miR-362 0-3p,miR-3621,miR-3622a-3p,miR-3622b-5p,miR-3646, miR-3648,miR-3649,miR-3650,miR-3651,miR-3652,miR-3654,miR-365��, miR-3659,miR-360,miR-361,miR-3663-5p,miR-3663-3p,miR-3665,mi R-3667-3p,miR-367-3p,miR-3675-3p,miR-3679-5p,miR-3 679-3p,miR-3682-3p,miR-3685,miR-3689a-3p,miR-3691-5p,miR-3692- 5p,miR-3713,miR-3714,miR-3714,miR-3689b-3p,miR-3689c,miR-3911,m iR-3917,miR-3918,miR-3919,miR-3150b-3p,miR-3922-3p,miR-3925-5p ,miR-676-3p,miR-3929,miR-3934-5p,miR-3935,miR-3936,miR-3937,miR-3940-3p,miR-3944-3p,miR-3945,miR-642b-3 p,miR-550b-3p,miR-1268b,miR-4420,miR-4421,miR-378g,miR-4425,mi R-4428,miR-4429,miR-4430,miR-4431,miR-4433a-3p,miR-4435,miR-44 36a,miR-4437,miR-4438,miR-4439,miR-4440,miR-4441,miR-4443,miR- 4444,miR-4445-3p,miR-4446-3p,miR-4447,miR-4448,miR-449,miR-44 50,miR-4451,miR-4453,miR-4454,miR-44556,miR-4458,miR-3 78h,miR-3135b,miR-4462,miR-4463,miR-4465,miR-4466,miR-4467,miR -4470,miR-4472,miR-4474-3p,miR-4475,miR-4476,miR-4478,miR-3689 d,miR-3689f,miR-4479,miR-3155b,miR-4483,miR-4484,miR- 4486,miR-4487,miR-4488,miR-4489,miR-4491,miR-4492,miR-4494,miR -4496,miR-4497,miR-4498,miR-499,miR-4502,miR-4505,miR-4506,mi R-2392,miR-4507,miR-4508,miR-4510,miR-4513,miR-4514,miR-4516,m iR-4518,miR-4520-3p,miR-4521,miR-1269b,miR-4522,miR-4523,miR-4 524a-3p,miR-4525,miR-4526,miR-4529-3p,miR-4530,miR-4531,miR-45 33,miR-4534,miR-378i,miR-4535,miR-1587,miR-4537,miR-4 539,miR-4540,miR-3120-5p,miR-3127-3p,miR-3129-3p,miR-3150a-5p,miR-3152-5p,miR-3074-5p,miR-3156-3p,miR-3158-5p,miR-3160-5p,mi R-3162-3p,miR-3173-5p,miR-3187-5p,miR-3189-5p,miR-3619-3p,miR-3 691-3p,miR-3150b-5p,miR-3922-5p,miR-3940-5p,miR-3944-5p,miR-44 23-5p,miR-446-5p,miR-4520-5p,miR-4529-5p,miR-3960,miR-3972,miR -463-3p,miR-4634,miR-4635,miR-4638-5p,miR-4640-5p ,miR-4640-3p,miR-4641,miR-4642,miR-46446-5p,miR-4646-3p ,miR-4647,miR-4648,miR-4649-3p,miR-4650-3p,miR-465 1,miR-4652-5p,miR-4653-5p,miR-4654,miR-4655-5p,miR- 4656,miR-4657,miR-4658,miR-460,miR-461-3p,miR-464-5p,miR-46 64-3p,miR-4665-5p,miR-4665-3p,miR-467-3p,miR-219b- 5p,miR-4669,miR-4672,miR-4673,miR-4674,miR-4676-5p,miR-4676-3p ,miR-4677-5p,miR-4681,miR-4682,miR-4684-5p,miR-4684-3p,miR-4685 -5p,miR-4685-3p,miR-4687-5p,miR-1343-3p,miR-4688,miR- 4689,miR-4690-5p,miR-4691-5p,miR-4692,miR-4695-5p,miR-4695-3p,m iR-4697-5p,miR-4697-3p,miR-4698,miR-4700-5p,miR-4700-3p,miR-47 01-5p,miR-4701-3p,miR-4706,miR-4707-5p,miR-4707-3p,miR-4708-5p,miR-4708-3p,miR-4709-5p,miR-4709-3p,miR-4711-3p,miR-4 713-5p,miR-4713-3p,miR-4714-5p,miR-4716-3p,miR-352 9-5p,miR-4717-5p,miR-4717-3p,miR-4718,miR-4720-5p,miR-4721,miR -4722-5p,miR-4722-3p,miR-4723-3p,miR-4724-5p,miR-4 725-5p,miR-4725-3p,miR-4726-5p,miR-4727-3p,miR-472 8-5p,miR-4728-3p,miR-4730,miR-4731-3p,miR-4732-5p, miR-4732-3p,miR-4734,miR-47364-5p,miR-3064-3p ,miR-4738-3p,miR-4740-5p,miR-4740-3p,miR-4743-5p,miR- 122b-3p,miR-4745-5p,miR-4746-3p,miR-4748,miR-4749- 5p,miR-4749-3p,miR-4750-5p,miR-4753-3p,mi R-371b-3p,miR-4754,miR-4755-3p,miR-4756-5p,miR-475 6-3p,miR-4758-5p,miR-4758-3p,miR-4763-5p,miR-4763-3p, miR-4764-5p,miR-4769-5p,miR-4769-3p,miR-4773,miR-4 776-5p,miR-4776-3p,miR-4778-5p,miR-4779,miR-4780,miR-4436b-5p, miR-4436b-3p,miR-4781-5p,miR-4783-3p,miR-4785,miR-246 7-3p,miR-4786-3p,miR-4787-5p,miR-4787-3p,miR-4788,miR-4793-3p,miR-4794,miR-4800-5p,miR-4800-3p,miR-4801,miR-480 4-3p,miR-642a-3p,miR-550a-3-5p,miR-4433a-5p,miR-4482-3p,miR-49 99-5p,miR-5000-5p,miR-5000-3p,miR-5001-3p,miR-5002 -5p,miR-5002-3p,miR-5003-3p,miR-5004-3p,miR-5006-5 p,miR-5006-3p,miR-5007-5p,miR-5009-3p,miR-5010-3p, miR-5087,miR-5088-5p,miR-5089-5p,miR-50903,miR-5187-5p ,miR-5187-3p,miR-5188,miR-5189-5p,miR-5190,miR-5192,miR-5193,m iR-5194,miR-5195-5p,miR-5196-5p,miR-5196-3p,miR-4524b-5p,miR-4 524b-3p,miR-5571-5p,miR-5571-3p,miR-5100,miR-5572,miR-664b-p ,miR-664b-3p,miR-5580-5p,miR-5581-5p,miR-5581-3p,m iR-5584-5p,miR-5584-3p,miR-5585-3p,miR-5587-3p,miR-548au-3p,mi R-5588-5p,miR-5588-3p,miR-5589-5p,miR-5684,miR-5681b, miR-5690,miR-5694,miR-5698,miR-5702,miR-5703,miR-5704,miR-5705 ,miR-5708,miR-197-5p,miR-204-3p,miR-211-3p,miR-345-3p,miR-584- 3p,miR-652-5p,miR-660-3p,miR-1185-2-3p,miR-766-5p,miR-873-3p,m iR-1285-5p,miR-1304-3p,miR-1247-3p,miR-1255b-2-3p,miR-1306-5p,miR-3184-3p,miR-3191-5p,miR-642b-5p,miR-365b-5p,miR-1185-1-3 p,miR-3190-3p,miR-98-3p,miR-216a-3p,miR-381-5p,miR-495-5p,miR-503-3p,miR-7, 58-5p,miR-939-3p,miR-1227-5p,miR-1229-5p,miR-1233-� p,miR-1236-5p,miR-1237-5p,miR-1238-5p,miR-1292-3p,miR-3617-3p, miR-3620-5p,miR-3927-5p,miR-3934-3p,miR-4632-5p,miR-4750-3p,mi R-5089-3p,miR-5739,miR-5787,miR-6068,miR-6069,miR-6071,miR-6072 ,miR-6074,miR-6075,miR-6076,miR-6077,miR-6080,miR-6081,miR-608 3,miR-6084,miR-6085,miR-6086,miR-6089,miR-6090,miR-6124,miR-612 5,miR-6126,miR-6127,miR-378j,miR-6129,miR-6130,miR-6131,miR-61 32,miR-6133,miR-6165,miR-6499-3p,miR-6500-3p,miR-65 01-5p,miR-6501-3p,miR-6503-5p,miR-6504-5p,miR-6504 -3p,miR-6505-3p,miR-6506-5p,miR-6507-3p,miR-6508-5p,miR-6509-5p ,miR-6509-3p,miR-6510-5p,miR-6511a-5p,miR-6511a-3p,miR-6512-3p ,miR-6513-3p,miR-6514-5p,miR-6515-5p,mi R-6515-3p,miR-6715a-3p,miR-6715b-5p,miR-6716-5p,mi R-6717-5p,miR-6511b-5p,miR-6511b-3p,miR-6718-5p,miR-6719-3p,miR -6721-5p,miR-6722-5p,miR-6722-3p,miR-6724-5p,miR-892c-5p,miR-8 92c-3p,let-7c-3p,miR-210-5p,miR-128-1-5p,miR-134-3p,miR-370-5p,miR-433-5p,miR-329-5p,miR-410-5p,miR-487a-5p,miR-489-5p,miR-49 4-5p,miR-504-3p,miR-487b-5p,miR-579-5p,miR-585-5p,mi R-605-3p,miR-619-5p,miR-656-5p,miR-68-5p,miR-1296-3p,miR-130� -5p,miR-1298-3p,miR-874-5p,miR-889-5p,miR-887-5p,miR-1250-3p,mi R-1251-3p,miR-1266-3p,miR-1288-5p,miR-1910-3p,miR- 3192-3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,miR-5088-3p,miR-518 9-3p,miR-5699-5p,miR-6720-5p,miR-6726-3p,miR-6727- 5p,miR-6727-3p,miR-6728-3p,miR-6729-5p,miR-6729-3p, miR-6730-5p,miR-6730-3p,miR-6731-3p,miR-6732-5p,mi R-6732-3p,miR-6734-5p,miR-6735-3p,miR-6 736-3p,miR-6737-5p,miR-6737-3p,miR-6738-3p,miR-673 9-3p,miR-6740-5p,miR-6741-3p,miR-6741-3p,miR-6742-5 p,miR-6742-3p,miR-6743-3p,miR-6744-5p,miR-6744-3p, miR-6745,miR-6746-5p,miR-6747-3p,miR-67 48-5p,miR-6748-3p,miR-6749-3p,miR-6750-5p,miR-675�- 3p,miR-6751-3p,miR-6752-5p,miR-6752-3p,miR-6753-5p,miR-6753-3p,miR-6754-3p,miR-6755-5p,miR-6756-5p,mi R-6756-3p,miR-6757-3p,miR-6758-5p,miR-6759-5p,miR-6 759-3p,miR-6760-5p,miR-6760-3p,miR-6761-3p,miR-676 2-5p,miR-6762-3p,miR-6763-5p,miR-6763-3p,miR-6764-3p,miR-6765-5 p,miR-6766-5p,miR-6766-3p,miR-6767-5p,miR-6768-5p,miR-6769a-5p ,miR-6769a-3p,miR-6770-5p,miR-6770-3p,miR-6771-3p,miR-6772-5p,m iR-6772-3p,miR-6773-3p,miR-6774-3p,miR-6775-5p,miR -6775-3p,miR-6776-5p,miR-6777-3p,miR-67 78-5p,miR-6779-5p,miR-6779-3p,miR-6780a-5p,miR-678 0a-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-6782-3p,miR-6783- 5p,miR-6783-3p,miR-6784-3p,miR-6785-3p,miR-6786-�p ,miR-6786-3p,miR-6787-5p,miR-6787-3p,miR-6788-5p,mi R-6789-3p,miR-6790-5p,miR-6790-3p,miR-6791-3p,miR- 6792-5p,miR-6792-3p,miR-6793-3p,miR-6794-5p,miR-679 4-3p,miR-6795-3p,miR-6796-5p,miR-6796-3p,miR-6797- 5p,miR-6797-3p,miR-6798-3p,miR-6799-5p,miR-6799-3p,miR-6800-5p,miR-6800-3p,miR-6801-3p,miR-6802-3p,mi R-6803-3p,miR-6804-5p,miR-6804-3p,miR-6805-5p,miR- 6805-3p,miR-6806-5p,miR-6807-5p,miR-6808-5p,miR-68 09-3p,miR-6810-5p,miR-6810-3p,miR-6812-3p,miR-6813- 5p,miR-6813-3p,miR-6814-3p,miR-6815-5p,miR-6815-3p ,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-6817-3p,miR-6819-5p,mi R-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821-3p,miR- 6822-5p,miR-6822-3p,miR-6823-3p,miR-6824-5p,miR-682 4-3p,miR-6825-5p,miR-6825-3p,miR-6827-5p,miR-6827- 3p,miR-6828-5p,miR-6829-3p,miR-6830-5p,miR-6830-3p ,miR-6831-3p,miR-6831-3p,miR-6832-3p,miR-6833-5p,m iR-6833-3p,miR-6834-3p,miR-6780b-3p,mi R-6836-5p,miR-6837-5p,miR-6838-5p,miR-6839-5p,miR- 6840-5p,miR-6840-3p,miR-6841-3p,miR-6842-5p,miR-6842-3p,miR-684 3-3p,miR-6845-3p,miR-6846-5p,miR-6846-3p,miR-6847- 5p,miR-6847-3p,miR-6848-3p,miR-6849-3p,miR-6850-5p,miR-6851-3p,miR-6852-5p,miR-6852-3p,m iR-6853-5p,miR-6854-3p,miR-6855-5p,miR -6857-3p,miR-6858-5p,miR-6858-3p,miR-6859-5p,miR-6 859-3p,miR-6769b-5p,miR-6860,miR-6861-3p,miR-6862- 5p,miR-6862-3p,miR-6863,miR-6865-3p,miR-6867-5p,miR-6867-3p,mi R-6868-5p,miR-6868-3p,miR-6869-5p,miR-6870-3p,miR- 6871-5p,miR-6871-3p,miR-6872-3p,miR-6873-3p,miR-6874-5p,miR-68 75-5p,miR-6876-5p,miR-6876-3p,miR-6877-5p,miR-6877 -3p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3 p,miR-6881-3p,miR-6882-5p,miR-6882-3p,miR-6883-5p, miR-6883-3p,miR-6884-3p,miR-6885-3p,miR-6886-5p,mi R-6886-3p,miR-6887-3p,miR-6888-5p,miR-6889-5p,miR- 6889-3p,miR-6890-3p,miR-6891-3p,miR-6891-3p,miR-68 92-3p,miR-6893-3p,miR-6894-3p,miR-6894-3p,miR-6895 -5p,miR-6895-3p,miR-7106-5p,miR-7106-3p,miR-7107-5p,miR-7108-5 p,miR-7108-3p,miR-7109-5p,miR-7110-3p,miR-7111-5p,miR-711-3p,miR-7112-5p,miR-7113-3p,miR-71 14-5p,miR-7114-3p,miR-7151-5p,miR-7151-3p,miR-7152-5p,miR, -7152-3p,miR-7154-3p,miR-7155-3p,miR-7155-3p,miR-7 157-5p,miR-7157-3p,miR-7158-5p,miR-7160-5p,miR-7162-3p,miR-75� 5,miR-7702,miR-7843-5p,miR-4433b-3p,miR-1273h-5p, miR-1273h-3p,miR-6516-5p,miR-7846-3p,miR-7847-3p,m iR-7850-5p,miR-7851-3p,miR-7854-3p,miR-7855-5p,miR -8052,miR-8054,miR-8057,miR-8059,miR-8060,miR-8062,miR-8063,mi R-8064,miR-8069,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,m iR-8075,miR-8077,miR-8079,miR-8080,miR-8082,miR-8083, miR-8085,miR-8086,miR-8087,miR-80889,miR-1199-3p,miR-7 975,miR-7976,miR-7978,miR-1249-5p,miR-485-5p,miR-848 5,miR-103a-1-5p,miR-196a-1-3p,miR-135a-2-3p,miR-375-5p,miR-526 a-3p,miR-9718,miR-9898,miR-1843,miR-9986,miR-10226,mi R-10392-5p,miR-10394-3p,miR-10395-5p,miR-10395-3p ,miR-10396a-3p,miR-10398-5p,miR-10398-3p,miR-104 00-3p,miR-10401-5p,miR-10401-3p,miR-10396b-3p,mi R-10522-5p,miR-10523-5p,miR-10526-3p,miR-10527-5p,miR-1181-5p,miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-5p, miR-3059-3p, miR -3085-5p, miR-3085-3p, miR-6529-5p, miR-12114, miR-12115, miR-12116, miR-1211 7, miR-12118, miR-12119, miR-12120, miR-12121, miR-12122, miR-12124, miR-12125, miR-12126, miR-12127, miR-12128, miR-12131, and miR-12136 (Uro); The urine is from a subject having or suspected of having lung cancer. method.

29. The method according to any one of claims 25 to 28, comprising detecting five or more types of microRNA.

30. The method of any one of claims 25 to 28, comprising detecting 10 or more, 15 or more, or 20 or more microRNAs.

31. The method according to any one of claims 25 to 28, wherein the microRNA is a microRNA that further satisfies the condition in Tables 4-1 to 4-15 that its expression is increased in lung cancer patients {in each table, the microRNA may be one or more types, two or more types, three or more types, four or more types, five or more types, ten or more types, fifteen or more types, or twenty or more types of microRNA}.

32. The method according to any one of claims 25 to 28, wherein the microRNA is a microRNA that further satisfies the condition in Tables 4-1 to 4-15 that its expression is reduced in lung cancer patients {in each table, the microRNA may be one or more types, two or more types, three or more types, four or more types, five or more types, ten or more types, fifteen or more types, or twenty or more types of microRNA}.

33. 1. A method for predicting the likelihood of a subject having early stage lung cancer in a subject having or suspected of having lung cancer, comprising:

26. The method according to claim 25, wherein the microRNA further satisfies the condition in Tables 4-1 to 4-15 that its expression is increased in lung cancer patients {in each table, the microRNA may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; the presence of a microRNA with expression greater than a first threshold indicates a likelihood that the subject from which the urine was derived has early stage lung cancer; method.

34. 1. A method for predicting the likelihood of a subject having early stage lung cancer in a subject having or suspected of having lung cancer, comprising:

26. The method according to claim 25, wherein the microRNA further satisfies the condition in Tables 4-1 to 4-15 that expression is reduced in cancer patients {in each table, the microRNA may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; the presence of a microRNA with expression below a first threshold indicates a likelihood that the subject from which the urine was derived has lung cancer; method.

35. The method of claim 33, wherein the number of microRNAs showing expression higher than the first threshold is five or more.

36. The method of claim 33, wherein the number of microRNAs showing expression higher than the first threshold is 10 or more, 15 or more, or 20 or more.

37. The method of claim 34, wherein the number of microRNAs whose expression is lower than the second threshold is five or more.

38. The method of claim 34, wherein the number of microRNAs whose expression is lower than the second threshold is 10 or more, 15 or more, or 20 or more.

39. The method according to any one of claims 1 to 38, which is an in vitro method.

40. The method of any one of claims 10 to 39, wherein the nanowires are nanowires having a metal oxide surface.

41. 41. The method of claim 40, wherein the nanowires are nanowires having a zinc oxide surface.

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