Temperature measuring device and system for measuring human core body temperature

Abstract

The measuring device (3) can be wrapped around the wearer's arm. The measuring device comprises at least three skin temperature sensors (33) on a first inner surface (31) that extend over at least a portion of the circumference of the measuring device in a first zone (Z33) of the device, and at least one cavity temperature sensor (34) on a second outer surface (32) in a second zone (Z34) of the device for measuring the temperature in or near the armpit. The zones (Z33, Z34) are positioned at least partially opposite or substantially adjacent to each other.

Description

[Technical field]

[0001] The present invention relates to the technical field of devices for measuring and determining human core body temperature. The temperature value of interest to practitioners is the deep body temperature, also called "core temperature" or "core body temperature" or "CBT." It is the temperature inside the body, and therefore includes the blood and vital organs such as the heart, liver, kidneys, and lungs.

[0002] The core temperature of a human being can be measured by many types of sensors, such as invasive probes intended to equip the patient during surgery or in certain intensive care situations, for example sensors intended to be placed in the esophagus via the oral route, or sensors placed in the bladder via the urethral route or via an intravascular route, in particular via a catheter equipped with a thermal sensor.

[0003] All these different kinds of sensors are invasive, therefore difficult to use and can be a source of vectorization of pathogens in the patient's body, and for this reason are limited to certain cases. There is a real need to know and monitor the core body temperature, since creating a reliable and maintainable non-invasive device, especially in routine hospital care or at home care, offers many medical possibilities for establishing a diagnosis, for protocols for monitoring or for adapting drugs to the patient. Therefore, research has been conducted to obtain this item of data without the need to measure core body temperature, by inferring the value of core body temperature based on items of information reconstructed from different peripheral skin sensors.

[0004] For this estimate or inference to be accurate, such a device must: taking into account the fact that each part of the body is subject to thermoregulatory mechanisms and thus obtains temperature measurements that differ from other parts of the body and from the core body temperature; Take into account the fact that the temperature of each site depends on its particular local conditions at the time of measurement. Indeed, as soon as the temperature of the surroundings is measured, the selected site is necessarily exposed to very particular conditions. For example, when making an ear measurement, it is well understood that this measurement is influenced by whether or not the patient is lying down relative to the ear on which the measurement is made, and similarly, when measuring the arm, it is well understood that the measured temperature will differ depending on whether or not the arm is covered by a bed cover; Take into account the fact that the temperature of the measurement site depends on that particular physical or biological activity at the time of measurement, which can potentially raise or lower the temperature of the site independently of the rest of the body. For example, the temperature of the brain, and therefore the temperature of the head, changes according to the activity of the brain, and similarly, the temperature of the armpits changes as a function of the activity of the muscle groups of the arm. These temperature variations are local, but also affect other surrounding sites. However, they are compensated by the body so that they do not directly affect the core body temperature. Thus, physical activity, mental activity, digestive activity, and certain biological reactions of the body (local inflammation) can create misleading local differences.

[0005] In addition to the factors disclosed above that affect especially the core body temperature, the specific design of the measuring device brings about other requirements, all of which are equally important to take into account: Ergonomic constraints of the worn device: since the worn device is a measuring device worn on the body for potentially several days, it is necessary to ensure that the patient's discomfort is limited as much as possible and that the user is as free as possible from irritation in the postures and movements that he or she adopts, and conversely, that these postures and movements do not hinder the correct operation of the device; Ergonomic constraints in the procedure for wearing the measuring device: the intention is that this action should be easy and quick, preferably respecting the patient's privacy; Difficulties with accuracy during fitting: It is desirable for the measurement device to be able to be fitted in an accurate and reproducible manner in order to provide robust data; Morphological and biological variations between individuals: If humans are considered in their extreme diversity and take into account the different stages of individual development, it is easily understood that it is difficult to create a single measuring device that is suitable for all (from newborns to the elderly, healthy or sick people, including anorexic people or obese people with other comorbidities). However, it is desirable to limit the number of versions, so that each version is as adaptable as possible. Prior art

[0006] A temperature measuring device is known from document US 2011 / 243183 in the form of a patch that can be applied to the human body, in particular to the forehead, the back of the head, the chest or the center of the back, which patch is intended to remain in place on the body for an extended period of time in order to provide continuous temperature monitoring.

[0007] The device described in this document comprises a thermal insulation support comprising at least two measuring parts, each measuring part itself comprising a body surface temperature sensor placed on the inner surface of the thermal insulation support in contact with the wearer's body, a layer for monitoring the release of heat adjacent to the outer surface of the thermal insulation support, an outside air temperature sensor placed on the outer surface of said layer and an intermediate sensor of the temperature at the interface between the thermal insulation support and said layer. The measurements taken by these three temperature sensors (i.e., the body surface temperature sensor, the outside air temperature sensor, and the intermediate sensor for the temperature at the interface) are used to determine the wearer's core body temperature.

[0008] This measuring device is not entirely satisfactory. In particular, it provides body surface temperature measurements that are highly dependent on the positioning of the patch relative to the wearer. Furthermore, the influence of external parameters that affect the measured temperature is not optimally taken into account. As a result, there is a risk that the determined core body temperature will be inaccurate. Summary of the Invention

[0009] In this disclosure of the invention and in describing embodiments of the invention, the expressions "configured to" and "arranged to" are used in an equivalent manner. The object of the present invention is to overcome all or some of the above mentioned drawbacks while enabling the determination of human core body temperature in an accurate, reliable and effective manner, ultimately with the aim of improving patient monitoring and treatment.

[0010] To this end, according to a first aspect, the invention relates to a device for measuring multiple temperatures with the purpose of determining the core body temperature of a human being, the human being wearing said measuring device, the measuring device having a first side and a second side opposite to the first side and configured such that the measuring device can be at least partially wrapped around itself and into a wearing configuration forming at least one cylindrical portion having an axis (Z), the first side being wrapped towards the axis (Z), the measuring device, in its wearing configuration, intended to at least partially surround the arm of the wearer in the vicinity of the wearer's corresponding armpit, such that the axis (Z) of the measuring device substantially coincides with the axis of said arm, the first side of the measuring device then being in contact with the skin of the wearer's arm.

[0011] According to the general definition of the invention, a measuring device comprises: at least three skin temperature sensors configured to measure a skin temperature of a wearer, the skin temperature sensors being positioned on or near a first face of the measurement device in a first zone of the measurement device and extending substantially around at least a portion of a circumference of the measurement device in the worn configuration, preferably the at least three skin temperature sensors are positioned in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors and the wearer's skin; and / or The first surface of the measuring device is arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the first surface and the skin of the wearer's arm, and at least three skin temperature sensors are placed on this first surface and directed towards the outside of the device according to the invention. at least three skin temperature sensors; at least one cavity temperature sensor configured to measure a temperature in or near said underarm of the wearer, the cavity temperature sensor being located on or near a second surface of the measuring device in a second zone of the measuring device, preferably the at least one cavity temperature sensor is positioned in direct contact with the wearer's underarms without an intermediate layer between the at least one cavity temperature sensor and the wearer's underarms; and / or The second surface of the measuring device is arranged in direct contact with the wearer's underarm without an intermediate layer between the second surface and the wearer's underarm, and at least one cavity temperature sensor is located on this second surface and directed towards the exterior of the device according to the invention. At least one cavity temperature sensor; Equipped with The first zone of the skin temperature sensor and the second zone of the one or more cavity temperature sensors are positioned at least partially opposite or substantially adjacent to each other and project in a plane perpendicular to the first and second faces.

[0012] The measuring device can therefore be wrapped around the wearer's arm, preferably fitted closely to this arm shape. In addition, positioning the skin temperature sensors on or near the first side of the device allows them to be applied as closely as possible to the wearer's skin. The invention therefore allows the temperature to be measured in a particularly accurate and relevant manner based on different sensors. The location of these different sensors can provide the data necessary for the algorithm to estimate the core body temperature. Furthermore, the measuring device can easily remain in place on the wearer's arm and can remain there for the time required to make temperature measurements useful for the diagnosis and long-term monitoring of the patient.

[0013] The number of cavity temperature sensors is preferably less than the number of skin temperature sensors. When in position, the measuring device rests substantially transversely on the wearer's arm along the circumference of the arm. It is provided that the measuring device can wrap completely around the wearer's arm in less than one revolution, or conversely more than one revolution, for example overlapping itself or forming a helix around the wearer's arm. For example, in the worn configuration, the measuring device can extend angularly (i.e. around the Z axis of the cylinder) at least 90°, preferably at least 180°, and even better at least 270°, or more than 360°. It should be noted that a given measuring device, when worn, can cover more or less angular turns depending on the diameter of the wearer's arm.

[0014] Specifically, the circumferential line corresponds to the winding direction of the measuring device and can correspond to the length of the measuring device. The circumferential line can typically lie in a plane perpendicular to the axis (Z) of the cylinder formed by the measuring device, i.e., perpendicular to the axis of the wearer's arm. Positioning the measuring device on the arm has several advantages, namely that the measuring device is positioned flush with the thin layer of flesh and fat, and to a lesser extent in obese people, allowing a distortion-free measurement (in other words, a more accurate measurement of arterial temperature values). Moreover, this positioning offers the prospect of being acceptably comfortable for the wearer and reasonably accessible to another person to put on or take off the device or to examine the condition of the body zone where the measuring device is placed, while limiting the invasiveness of these actions for the wearer. Another advantage is that the installation is simple and quick, since all sensors are grouped together on a single device.

[0015] According to a feature of the invention, the measuring device is in the form of an arm band to be worn on the human arm, preferably in the vicinity of the armpit, for the purpose of obtaining skin temperature values ​​at the brachial artery. This positioning in the vicinity of the end of the humeral head allows close proximity between a temperature sensor properly attached to the surface of the skin on the inner surface of the arm and a large portion of the brachial artery. Advantageously, the arm band can be positioned entirely around the arm or can cover only a portion of the lateral part of the arm, i.e. only partially encircle the wearer's arm.

[0016] In the present invention, the term "skin temperature" means the temperature measured as close as possible to the wearer's skin, preferably on the skin. The skin temperature sensor is preferably positioned in a zone supplied with blood by a large blood flow, the target part of which is closest to the heart and advantageously also close to the vital organs, to avoid measuring a temperature that is highly dependent on the external temperature.

[0017] By ensuring that the skin temperature sensor extends over at least a portion of the circumference of the measuring device in the worn configuration, it is possible to obtain multiple skin temperatures measured in a desired zone, in this case around the brachial artery, and as opposed to it as possible. This makes it possible to obtain meaningful measurements of the brachial artery temperature, despite fluctuation phenomena that interfere with the measurement, as will be explained in the following paragraphs. Obtaining these meaningful measurements of the brachial artery temperature is an important item of data in the algorithm for estimating core body temperature.

[0018] The advantage of having a measuring device with several skin temperature sensors, more specifically at least three skin temperature sensors, comes from the observation that the hottest point of the skin is difficult to locate and can move as a function of time. More specifically, locating the hottest point is initially difficult, since the variation between people is large and the temperature difference in question is very small (in this part of the body, the difference between two points on the circumference separated by 1 cm is often less than 0.2°). This hottest point can move over time due to various phenomena, namely due to physical activity, especially the activity of the biceps, due to postures that create a specific geometric location relative to the source of heat or cold, especially relative to the torso, and finally due to the location of the wearer's arm, which can be vertical, inclined or horizontal and be more or less shaped by objects, affecting the conduction and the internal location of the flesh and arteries, and also directly affecting the diffusion of heat from the arteries through the flesh to the sensor zone.

[0019] It is therefore more sensible to have several skin measurement points to have the temperature sequence of this zone available and to analyze their changes over time. This plurality of skin temperature sensors forms a skin sensor group. Furthermore, the use of several sensors makes it possible to corroborate the article of skin temperature data and to refine it for further accuracy and reliability of the data provided to the algorithm for determining the wearer's core body temperature. It is noted that this advantage is obtained without a significant price increase, since the temperature sensors are reasonably priced.

[0020] Preferably, at least five skin temperature sensors may be provided, for example seven skin temperature sensors. Increasing the number of skin temperature sensors allows for an increased accuracy of the temperature determined based on skin temperature measurements at different points. Preferably, the device continuously collects the temperatures obtained from the skin sensors, and in a first step, it is the maximum measured temperature value from among the skin temperature sensors that is important. It is noted that in fact it is possible that the maximum measured temperature value is measured by a first sensor at time t and by a second sensor at time t+n, especially when the posture changes or when the wearer's activity changes over time, leading to a certain increase in muscle temperature.

[0021] In a second step, it is important to verify the fact that there is no maximum temperature among the skin temperature sensor placed in the end position of the plurality of these sensors. This gives an indication regarding the correct fit of the measuring device to the wearer. Thus, if the maximum temperature is measured by a skin temperature sensor placed in one of the two end positions, there may well be a concern that the maximum temperature measurable in the periphery is not measured by any of the sensors of the sensor group. If such conditions persist, there is a high risk that no truly usable data is obtained for the actual temperature of the artery and therefore the core body temperature cannot be accurately estimated. It should be noted that a poor fit of the measuring device to the wearer may be observed in particular after poor positioning of the device, or after a sliding of the device over the measurement period, or after extreme movements or environmental conditions of the device, or according to the particular morphology of the wearer. Regardless of the cause, if these conditions persist, this may jeopardize the quality of the measurements and may trigger a warning for the device.

[0022] To avoid this, it has also been empirically observed that it is preferable for the sensors to cover a sufficient length, for example a length of the order of at least 50 mm for an adult arm, so as to limit the risk that the highest temperature will be located at one of the end sensors. For this purpose, it has been empirically observed that a distance of about 10 mm between two adjacent sensors makes it possible to correctly cover the zone and avoid significant errors. Skin temperature measurements must be highly accurate and highly reliable. Therefore, specialized temperature sensors for human health, integrating high-resolution analog-to-digital converters, have become popular.

[0023] In the present invention, the term "cavity temperature" refers to the temperature of the wearer's open cavity, in this case the area around the armpits. Cavity temperature is generally generated primarily by the wearer's own body, but can also result from other temperature sources such as the body of another person in physical contact with the wearer, a cooling or heating bag, the sun, etc. The measurement device according to the present invention can include multiple cavity temperature sensors. During operation of the measuring device, there may be sources of heat or cold that cause the temperature of the measuring device and the measured temperature to increase or decrease in a misleading manner.

[0024] Similar causes can also cause an increase or decrease in temperature in the zone of the body surrounding the skin temperature sensor, but this very real increase or decrease in temperature in this part of the body is often misleading as it is often only superficial and actually has little or no effect on the wearer's core body temperature.

[0025] Among these sources, it should be noted that first and foremost the wearer's own body torso can heat or cool the measuring device by conduction, radiation and optionally convection, i.e. the body of another individual, clothing or a bag, a support on which the wearer is placed (mattress, rails, etc.), air, a cooling or heating bag, any other external source of heat or cold, such as the sun, etc.

[0026] The use of at least one cavity temperature sensor in the measuring device makes it possible to take into account in particular the temperature fluctuations caused by the torso and, more generally, the presence of external heat or cold sources and to use the measured values ​​in calculations to distinguish between external temperature changes (extrinsic) and temperature changes of the body itself (endogenous) so as to obtain a more relevant core body temperature value, taking these circumstances into account.

[0027] Moreover, this measurement of one or more cavity temperatures makes it possible to take into account the position of the wearer. Thus, if the cavity temperature is much lower than the skin temperature, this cavity (here the armpit) is considered to be sufficiently open and therefore the wearer's limb (here the arm) is sufficiently far from the body or from the body that generates heat. Conversely, if the cavity temperature is substantially equal to the skin temperature, it is possible to infer from there that the cavity temperature sensor is a priori in the vicinity of the wearer's skin. These elements, here reduced to simple data for the sake of illustration, are essentially continuous variables that are important items of input information for the algorithms of the system, making it possible to determine the core body temperature with greater accuracy and reliability.

[0028] These factors are very complex. Thus, for example, if one imagines the presence of warm pajamas with a nearly closed cavity and some sweating under the arms, this configuration has multiple thermal effects: relative insulation of the torso from the device by the material of the pajamas, transpiration from the armpits towards the device, natural evapotranspiration under the armpits and evaporation through the pajamas, natural convection between the pajamas and the skin, etc. It should be understood that the purpose of the cavity sensor or sensors is to provide comprehensive information for all of these phenomena in order to correct the measurements made by the skin sensors. It is not the role of the cavity sensor to be very accurate. The cavity sensor makes the corrections.

[0029] The measurement device may include several cavity temperature sensors, the number of which may be at least three. The accuracy requirements are lower for cavity temperature measurements than for skin temperature measurements, so it is possible to choose simpler sensors such as thermocouples or thermistors, which are easier to implement and have lower cost. By "zone" over which the sensors extend is meant a preferably substantially rectangular surface surrounding as far as possible all of the sensors under consideration.

[0030] As mentioned above, the first zone in which the skin temperature sensor is arranged and the second zone in which the cavity temperature sensor is arranged can project at least partially opposite each other in a plane perpendicular to said first and second faces, meaning that in the thickness direction of the measuring device, these first and second zones are completely overlapped or there is a partial coverage of these first and second zones.

[0031] In a variant, the first and second zones can project substantially adjacently in a plane perpendicular to said first and second faces. This means that, when viewed in said projection plane, the first and second zones are not superimposed, but remain close to each other, or even connected, while being offset relative to each other. By "close" is meant that the separation distance between the first and second zones along said projection (i.e. the length of the smallest segment connecting these projections of the first and second zones) is less than 3 cm, preferably less than 1.5 cm, or less than 0.8 cm, or even less than 0.5 mm. When viewed in said projection plane, the first and second zones can be offset parallel to the axis (Z) or perpendicular to the axis (Z), or both.

[0032] According to a possible embodiment, the measuring device is flexible and is configured so that it can be transformed, preferably by rolling, between an unworn configuration and a worn configuration. This flexibility allows the measuring device to be easily positioned on the one hand and to be fitted closely to the shape of the arm on which it is placed on the other hand. The quality of the skin temperature measurements taken is significantly improved.

[0033] In particular, due to its flexibility, the measuring device can adapt to different convex or concave shapes of the wearer's body. The measuring device can be positioned in particular on arms with prominent biceps, on malnourished arms, on the arms of overweight people, on the arms of elderly people with thin skin that lacks elasticity, etc. Furthermore, the measuring device can be positioned on the wearer in different positions that can generate folds, for example in a recumbent position. Preferably, the measurement device is substantially inelastic, particularly in its longitudinal direction (corresponding to the circumference of the arm), to avoid a tourniquet effect on the wearer.

[0034] According to a possible embodiment, the measuring device is configured so that it can be in an unworn configuration, which is substantially flat. In a variant, in its unworn configuration, the measuring device can already be wound around a cylinder. The diameter of this cylinder can be larger than in the worn configuration, so that additional windings are necessary to place the measuring device in the worn configuration. Alternatively, the diameter of this cylinder can be smaller than in the worn configuration, so long as little or no gripping or tourniquet effect is generated. Advantageously, the diameter of the measuring device in the worn configuration can be adjusted to fit on the arm of the wearer.

[0035] The measuring device may also comprise at least one proximal temperature sensor configured to measure the ambient temperature in the immediate vicinity of the wearer's arm, the one or more proximal temperature sensors being arranged on or near the second face of the measuring device. The proximal temperature sensor (or the center of the proximal temperature sensors) may be angularly offset (i.e. around the Z-axis of the cylinder) by at least 90° in the wearing configuration of the measuring device relative to the axis of the cavity temperature sensor or the cavity temperature sensors. Preferably, the above-mentioned angular offset is about 180°. In other words, the proximal temperature sensor is preferably positioned substantially diametrically opposite the at least one cavity temperature sensor in the wearing configuration of the measuring device. Such a placement allows to obtain a reliable measurement of the proximal temperature while minimizing the influence of the wearer's body heat.

[0036] Preferably, in the unworn configuration, the distance between the skin temperature sensor and the at least one proximal temperature sensor is greater than 10 cm and / or less than 20 cm. Preferably, the at least one proximal temperature sensor is located on the second surface and faces towards the exterior of the device according to the invention. In other words, preferably the proximal temperature sensor is embedded so that it is positioned on the side of the arm facing outward and therefore not pointing towards the torso, while the one or more cavity temperature sensors are ensured to be positioned on the side of the arm facing towards the torso for those portions.

[0037] In the present invention, the term "proximal temperature" means a temperature measured in the immediate environment surrounding the measuring device and obtaining an item of temperature information in the immediate environment of the wearer, which temperature varies as a function, among other things, of the heat loss by the wearer, the heat gain or loss from the environment, and the characteristics of the clothes, sheets, covers used by the patient.

[0038] By placing the center of the proximal temperature sensor or sensors facing toward the outside of the wearer's body and substantially opposite at least one of the cavity or skin temperature sensors, it is possible to obtain a proximal temperature value that is only influenced by heat input from the wearer's body. Of course, this positioning will depend on the circumference of the wearer's arm, and thus the proximal temperature sensor can be further forward (i.e., toward the stomach) or further back (i.e., toward the back) on the wearer's body.

[0039] Furthermore, when the measuring device is positioned on the arm, near the armpit, the zone opposite the brachial artery is less vascular and more fatty, and therefore less responsive to internal variations in body temperature. Thus, the temperature measured by the proximal temperature sensor provides a specific measurement of the thermal environment in the immediate vicinity of the body as a whole.

[0040] In other words, in the unworn configuration, the distance between the skin temperature sensor (e.g., the center of the skin temperature sensor) and at least one proximal temperature sensor (e.g., the center of the proximal temperature sensor) is substantially equal to half the circumference of the wearer's arm, and is preferably greater than 10 cm and / or less than 20 cm, e.g., between 10 and 20 cm.

[0041] The angle values ​​can be converted into circumference measurements for a given arm and vice versa. For example, if the average circumference of an adult arm at the base of the armpit is considered to be 28 cm, it can be advantageously determined that the center of the skin temperature sensor is at a distance of 14 cm from the center of the proximal temperature sensor. Under these conditions, the centers of these two sensors are therefore placed exactly opposite each other for a wearer with an arm with a circumference of 28 cm, which is the preferred position. If this same measuring device is used to equip a wearer with an arm of a different size, for example an arm with a circumference of 20 cm, the point diametrically opposite the brachial artery is placed at 10 cm. Assuming that the measuring device is placed with the center of the skin temperature sensors over the artery, the position of the center of the proximal temperature sensors according to the above configuration is 4 cm from the theoretical target point, creating an acceptable front-to-back offset depending on the orientation of the measuring device. These values ​​can also be expressed in degrees, with the centre of the skin temperature sensor forming an angle of 14cm / 20cm x 360° = 252° with the centre of the proximal temperature sensor, and the anterior-posterior offset is 4cm / 20cm x 360° or 72°.

[0042] The measuring device may include a plurality of proximal temperature sensors in order to obtain as accurate as possible an estimate of the temperature around the body. According to a feature of the invention, the plurality of proximal temperature sensors preferably comprises at least two temperature sensors aligned along the longitudinal axis of the measuring device. The measuring device may be provided to be equipped with at least three proximal temperature sensors. The function of the one or more proximal temperature sensors is to provide a temperature measurement that allows to correct the temperature measurement made at the brachial artery by a skin temperature sensor, a function that can be sufficiently ensured by a single proximal temperature sensor.

[0043] The requirements for accurate proximal measurement are lower than for skin temperature measurements, so it is possible to choose simpler sensors such as thermocouples or thermistors, which are easier to implement and have lower costs. The measuring device can also comprise at least one sensor of additional physicochemical data. Depending on the type of sensor in question, the sensor can be arranged on or near a first side of the measuring device (in this case, the at least one physicochemical data sensor is preferably placed on the first side and directed towards the outside of the device according to the invention and / or arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the at least one physicochemical data sensor and the skin of the wearer's arm) or on or near a second side of the measuring device (in this case, the at least one physicochemical data sensor is preferably placed on the second side and directed towards the outside of the device according to the invention).

[0044] The addition of functionality by the physicochemical data sensor enhances by contextualizing the acquisition of measurements made by the measurement device according to the invention, thereby making it possible to remove or include measurements from inferred process temperature measurements due to environmental causes or particular conditions of the wearer.

[0045] According to the invention, the one or more additional physicochemical data sensors may be photoplethysmographs configured to measure the wearer's heart rate and oximetry. Advantageously, the photoplethysmograph may be positioned on a first side of the measuring device and intended to be in contact with the wearer's skin. The photoplethysmograph may be placed in the immediate vicinity of the central skin temperature sensor. This positioning is advantageous since it allows to increase the quality of the measurements due to a greater blood supply to the skin in this zone.

[0046] To accommodate placement of skin temperature sensors organized along at least a portion of the circumference of the measurement device in a worn configuration, it is possible to place the photoplethysmograph in the center of the group of skin temperature sensors, but offset sufficiently so that the two types of sensors present do not interfere with each other. Thus, by placing the device on a wearer with a central skin sensor over the brachial artery, the photoplethysmograph can be placed in the proper manner over the artery to effectively measure heart rate or oximetry.

[0047] Alternatively or additionally, the additional physicochemical data sensor may be a galvanometer configured to measure the level of sweat or perspiration secreted by the wearer's body. The galvanometer may comprise at least two sensors that measure low intensity electrical currents and allow identifying bodily waste products and determining the physicochemical composition of said waste products.

[0048] The galvanometer sensor is positioned on a first face of the measuring device, in contact with the wearer's skin. Preferably, the galvanometer sensor is positioned in an area central to the proximal temperature sensors, but on the opposite face of the device. Sweating in this zone is a reflection of the general sweating of the body, which is important to have general information about the wearer's condition.

[0049] Alternatively or additionally, a galvanometer sensor can be placed in the area of ​​the skin temperature sensors, making it possible to capture sweating specific to the underarm zone. Alternatively or additionally, the additional physicochemical data sensor may be a three-axis accelerometer, a gyroscope, or a GPS configured to obtain items of information relating to the kinematic activity of the wearer's body.

[0050] According to a possible embodiment, the first zone in which the skin temperature sensors are arranged is elongated and extends in the longitudinal direction of the measuring device, the skin temperature sensors being arranged in line or staggered in the elongated zone, which can also apply to cavity temperature sensors.

[0051] Staggered placement allows for an increased density of sensors in the reduced area, thus allowing for more accurate and more reliable measurements to be obtained while limiting the transfer of calories from one sensor to another. Furthermore, with this staggered placement, each sensor collects measurements that do not differ significantly compared to aligned positioning. At least one cavity temperature sensor may be positioned opposite said first zone of the skin temperature sensor, preferably substantially longitudinally centrally located. According to one embodiment, one or more cavity temperature sensors may face said zone without necessarily facing a skin temperature sensor.

[0052] According to another embodiment, at least one cavity temperature sensor is placed opposite at least one skin temperature sensor, preferably opposite the central skin temperature sensor, when the number of skin temperature sensors is odd.Preferably, this sensor is determined to be slightly eccentric to the line of skin temperature sensors, so that the skin temperature sensors are all embedded in a very similar mechanical environment (similar material conditions with similar insulation and heat transfer behaviors outside and with each other), and limit the interference of the cavity temperature sensor with the measurement.This placement allows accurate collection of skin temperature data of the brachial artery zone.

[0053] According to one embodiment, it is possible to provide two proximal temperature sensors, arranged at each end of the measuring device in the longitudinal direction, preferably arranged symmetrically with respect to the central sensor of the skin temperature sensors. With this arrangement, the proximal temperature sensors are distributed in two locations that can be widely spaced apart from each other, especially when the measuring device is substantially flat in the unworn configuration. However, when the measuring device is in the worn configuration, the proximal temperature sensors are located close to each other following rolling up of the measuring device.

[0054] According to a possible embodiment, each cavity temperature sensor is positioned opposite a skin temperature sensor, the axis of which may or may not be offset from the axis of the cavity temperature sensor. Preferably, the cavity temperature sensors are distributed throughout the zone of the measurement device in which the skin temperature sensors are located.

[0055] According to a feature of the invention, the skin temperature sensors and / or the cavity temperature sensors and / or the proximal temperature sensors are distributed over at least a portion of the measurement device having a longitudinal dimension of at least 45 mm.

[0056] The configuration of sensors, for example 7 distributed over 50mm, can vary depending on the diameter of the measurement device: for example, a baby's arm could be provided with 5 sensors distributed over 35mm, or an adult wearer with a very high BMI could be provided with 11 sensors distributed over 80mm. According to a feature of the invention, the skin temperature sensor and / or the cavity temperature sensor and / or the proximal temperature sensor are aligned on the longitudinal axis of the measurement device. According to a feature of the invention, the skin temperature sensors and / or cavity temperature sensors and / or proximal temperature sensors are regularly spaced with the same center-to-center distance.

[0057] According to a feature of the invention, the skin temperature sensors and / or cavity temperature sensors and / or proximal temperature sensors are arranged on respective sides of the measuring device in a staggered or angled arrangement. According to a possible embodiment, the measuring device is in the form of a band elongated in a longitudinal direction (X) that, in the worn configuration, substantially corresponds to the circumferential line of the measuring device, the band comprising: a length in the direction (X) preferably greater than 12 cm, better still greater than 15 cm or greater than 20 cm; In a direction substantially parallel to the axis (Z) of the cylinder in the worn configuration, the width is preferably less than 6 cm, better still less than 4 cm, for example about 3 cm. having The band has a central longitudinal axis, a central lateral axis, an upper edge, and a lower edge (when the measuring device is worn, the wearer is in a reference anatomical position, i.e., specifically standing, with arms along the body). At least one of the first side and the second side can have a flat surface in the unworn configuration. The skin temperature sensor and / or the at least one cavity temperature sensor may be positioned substantially along a central longitudinal axis of the band.

[0058] In a variant, the skin temperature sensor and / or at least one cavity temperature sensor can be offset in the direction of the upper edge relative to the longitudinal central axis of the band. The advantage of this placement is that the cavity temperature sensor can be placed as close to the armpit as possible. This can also be important for the skin temperature sensor. In fact, near the armpit, the brachial artery is flush under the skin of the arm, while away from the armpit, it is located deeper in the arm. The measuring device also an elongate tape supporting a skin temperature sensor and at least one cavity temperature sensor; a case including an electronic board and a battery connected to an elongate tape, the case preferably supporting at least one proximal temperature sensor, if present, and / or preferably supporting at least one additional physicochemical data sensor;

[0033] The case and elongate tape are covered with a flexible material, for example by overmolding.

[0059] Said flexible material may be an elastomer or medical grade silicone, which makes it possible to improve the comfort of the wearer of the measuring device and ensure uniform contact with the wearer's skin without separation. In the present invention, "medical grade silicone" means a material that has been tested for biocompatibility and is suitable for use in medical applications.

[0060] For example, it is possible to carry out injection molding of medical grade silicone of Shore A 35. According to this example, the measuring device can have a thickness substantially equal to 2.5 mm, and the electronics with the sensor are integrated in a Kapton tape of width 10 mm and thickness 0.20 mm. The tape forms a support for the sensor and also integrates the electronic connection elements. The measuring device may also have, on its first face and / or on its second face, a hygienic coating, which is advantageously washable. It may also comprise an adhesive part intended to be attached to the arm of a wearer.

[0061] According to a possible embodiment, the measuring device comprises: A first set of sensors, at least three skin temperature sensors positioned on or near a first face of the measuring device in a first zone of a first set of sensors and extending over a first length, preferably the at least three skin temperature sensors of the first set being arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the first set and the skin of the wearer and / or the first face of the measuring device being arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the first face and the skin of the wearer's arm, the at least three skin temperature sensors of the first set being placed on this first face and at least three skin temperature sensors being directed towards the exterior of the device according to the invention; at least one cavity temperature sensor arranged on or near the second face of the measuring device in a second zone of the first set of sensors of the measuring device, at least partially facing or substantially adjacent to the first zone of the first set of sensors and projecting in a plane perpendicular to said first and second faces, preferably at least one cavity temperature sensor of the first set arranged in direct contact with the wearer's armpits without having an intermediate layer between the at least one cavity temperature sensor of the first set and the wearer's armpits and / or the second face of the measuring device arranged in direct contact with the wearer's armpits without having an intermediate layer between the second face and the wearer's armpits, at least one cavity temperature sensor of the first set being placed on this second face and at least one cavity temperature sensor directed towards the outside of the device according to the invention; a first set of sensors including: a second set of sensors, at least three skin temperature sensors positioned on or near the second face of the measuring device in a first zone of the second set of sensors and preferably extending over a second length different from the first length, preferably the at least three skin temperature sensors of the second set being arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the second set and the skin of the wearer and / or the second face of the measuring device being arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the second face and the skin of the wearer's arm, the at least three skin temperature sensors of the second set being placed on this second face and at least three skin temperature sensors being directed towards the exterior of the device according to the invention; At least one cavity temperature sensor arranged on or near the first face of the measuring device in a second zone of the second set of sensors of the measuring device, at least partially facing or substantially adjacent to the first zone of the second set of sensors and projecting in a plane perpendicular to said first and second faces, preferably at least one cavity temperature sensor of the second set arranged in direct contact with the wearer's armpits without an intermediate layer between the at least one cavity temperature sensor of the second set and the wearer's armpits and / or the first face of the measuring device arranged in direct contact with the wearer's armpits without an intermediate layer between the first face and the wearer's armpits, and at least one cavity temperature sensor of the second set is located on this first face and at least one cavity temperature sensor directed towards the outside of the device according to the invention. a second set of sensors including Equipped with.

[0062] The device is preferably arranged to use or activate a single set of sensors at a time from the first set of sensors and the second set of sensors. Preferably, the number of cavity temperature sensors in the first set is less than the number of skin temperature sensors in the first set; The number of cavity temperature sensors in the second set is less than the number of skin temperature sensors in the second set. Therefore, the measuring device is a first position where the first surface is directed towards the wearer's arm (in this case, a first set of sensors is used); or a second position where the second side is facing the wearer's arm (in this case, a second set of sensors is used). The device can be placed on the wearer in either

[0063] In particular, the fact that the first set of skin temperature sensors is provided to extend over a different length compared to the second set of skin temperature sensors makes it possible to have a universal measuring device. More particularly, the first set can be adapted to an arm having a circumference in a first range of circumference values, and the second set can be adapted to an arm having a circumference in a second range of circumference values ​​different from the first range. Thus, a single device can be provided to be usable for virtually any wearer, regardless of its form or construction.

[0064] According to a second aspect, the invention relates to an assembly comprising a measuring device as described above and further a flexible sheath intended to receive the measuring device, the sheath preferably having windows facing each of the sensors of the measuring device and having, on its side intended to be in contact with the wearer's arm, at least one adhesive portion intended to be attached to the wearer's arm. The adhesive portion may, for example, comprise an adhesive layer covered by at least one band that can be peeled off before first use.

[0065] Alternatively, the measuring device may comprise a piece of non-adhesive adhesive material, for example made from polyurethane or low density silicone, which is intended to be positioned on the arm of the wearer. This piece has the advantage that it is cleanable and its adhesion is not as strong as that of glue, thereby not making it difficult to remove the measuring device from the arm on which it is positioned. The adhesion of this piece of non-adhesive adhesive material is generally not as strong as that of glue, and this piece must be finished with an adhesive band, for example brought by a nurse, to stabilize the measuring device on the arm, but to reliably connect the two ends of the measuring device.

[0066] According to a third aspect, the present invention provides a system for determining the core body temperature of a human, comprising: a device for measuring multiple temperatures or an assembly as described above; a processing unit configured and / or programmed to determine a core body temperature of a wearer of the measuring device based on the temperature data measured by the measuring device; The present invention relates to a system comprising: The guesses can be made by an algorithm that looks up a correspondence table built using experience.

[0067] According to a feature of the invention, the measuring device comprises at least one transmitter configured to transmit the measured temperature measurement information to the receiver, the transmitter may be an antenna for transmitting the temperature measurement information. The measuring device may comprise an element for displaying the determined core body temperature, the display element being an indicator screen and / or one or more light indicators, for example coloured or colourless electroluminescent diodes, which make it possible, for example, to give information about one or more operating states of the measuring device.

[0068] The processing unit may comprise at least one memory, preferably a cache memory, making it possible to collect the temperature data measured by the measuring device at regular or irregular time intervals and to store them. The processing unit may include a receiver configured and / or programmed to cooperate with a transmitter, e.g., a transmitting antenna, positioned in the measurement device. The receiver may be configured and / or programmed to communicate with a memory of the processing unit to store received temperature data.

[0069] The processing unit may include a display configured to display at least the core body temperature determined by the processing unit based on measurements made by the measurement device. The display may be configured to display the raw temperature data and the interval between measurements. The display of the system may be distinct and separate from the display element of the measurement device. The communication can be wired or wireless, for example by Bluetooth. The processing unit is preferably arranged and / or programmed to carry out steps d) and / or e) and / or g) and / or h) and / or i) as described below.

[0070] The subject of the invention is also a method for determining the core body temperature of a human being, said method being implemented by a determination system according to the invention, said method comprising the steps of: a) measuring at least one skin temperature at a time t or over a period p by at least three skin temperature sensors of a determination system according to the invention; b) measuring at least one cavity temperature at a time t or over a period p by means of at least one cavity temperature sensor of a measurement device of the measurement and determination system according to the invention; c) the measuring device sends the temperature data measured in steps a) and b) via a transmitter to a receiver equipped with a processing unit of the measuring and determining system according to the invention; d) a receiver in the processing unit receives the measured temperature data and transmits it to a memory in the processing unit where the temperature data is stored; The processing unit compares the skin temperature data for each sensor and determines the wearer's skin temperature for each sensor during time t or period p, e.g., using an average of the temperatures measured for that sensor; The processing unit performs a comparison for the or each cavity temperature sensor and determines the cavity temperature for the or each sensor, e.g., using an average of the temperatures measured for each sensor, during time t or period p. Steps and e) based on the items of temperature data held for each skin temperature sensor and one or each cavity temperature sensor, over a time t or at least one period p, the processing unit applies a decision model, for example using a correspondence table and / or based on a forest of decision trees and / or a neural network, to determine the wearer's core body temperature using the temperature data for each sensor during the time t or period p, or a set of data corresponding to the temperature data for each sensor collected during a rolling observation period P; Includes.

[0071] The method may include step f), performed in parallel with steps a) and / or b) and / or subsequent steps a) and b), consisting of measuring at least one proximal temperature at time t or over a period p. In this case, step d) preferably ends with processing of the proximal temperature measurements with a view to obtaining a single value for one or each proximal temperature sensor. Thus, for one or each proximal temperature sensor, the processing unit compares the values ​​and determines the proximal temperature for this sensor during time t or period p, for example using an average of the temperatures measured for each sensor. Processing e) then integrates this data or items of these data to complement the other temperature values ​​in order to determine the core body temperature.

[0072] According to a feature of the invention, the core body temperature can be determined by the processing unit as a function of additional parameters resulting from one or more additional physicochemical data sensors. Preferably, the determination of core body temperature may be made based on the measurements made in steps a), b), f) and based on data characterizing physiological arousal, said data being measured by a photoplethysmograph and / or a galvanometer.

[0073] Even more preferably, the determination of core body temperature can be made based on the measurements made in steps a), b), f) and based on data characterizing physiological arousal and based on positioning data measured, for example by a three-axis accelerometer. Preferably, the determination of core body temperature may be performed based on measurements made during a preferably rolling period P, in which a series of steps a), b) and f) are performed and a set of data characterizing physiological arousal is collected over this same period P.

[0074] According to a feature of the invention, after the wearer's core body temperature has been determined over a time t or at least one period p, the processing unit can instruct the display device to display the determined core body temperature during step g). The processing unit may be configured and / or programmed to determine, based on the determined core body temperature, during step h), a status of the wearer, e.g. by correlating the measured core body temperature with a status based on a database or nomogram integrated in the memory of the processing unit, where status of the wearer means, for example, a healthy state, a fever state or a critical state. According to a feature of the invention, the wearer's condition may be communicated by the processing unit during step i) to a display device which displays the wearer's condition.

[0075] The method according to the invention also comprises the steps of: After step a), a step a') of determining a single skin temperature value, preferably by selecting the highest value among the skin temperatures from or measured by at least three skin sensors; After step b), a step b') of determining a single cavity temperature value, preferably by selecting the highest value among the cavity temperatures from or measured by the at least one cavity temperature sensor; determining a core body temperature of the human wearer based on the single skin temperature value determined in step a' and the single cavity temperature value determined in step b'; may include.

[0076] The method according to the invention also comprises the steps of: A step FFF of measuring at least one proximal temperature at a time t or over a period p by at least one proximal temperature sensor; a step FFF' of determining a single proximal temperature value, preferably by selecting the highest value among the proximal temperatures from or measured by at least one proximal temperature sensor; determining a core body temperature of the human wearer based on the single skin temperature value determined in step a', the single cavity temperature value determined in step b', and the single proximal temperature value determined in step FFF'; may include. [Brief description of the drawings]

[0077] The invention will be better understood from the following description of embodiments according to the invention, given by way of non-limiting example and illustrated with reference to the accompanying schematic drawings, of which: [Figure 1] 2 is a top view of a measurement device according to an embodiment of the present invention in an unworn configuration, viewed from its second side. FIG. [Diagram 2] 2 is a top view of the measurement device of FIG. 1 in an unworn configuration, seen from its first side. [Diagram 3] FIG. 2 is a view similar to FIG. 1, showing internal components of the measuring device in a transparent view. [Figure 4] FIG. 2 is a partial side view of the measurement device of FIG. 1 in an unworn configuration. [Diagram 5] 2 is an exploded perspective view of a portion of the measurement device of FIG. 1 showing the elongated tape and case. [Figure 6] FIG. 6 is a perspective view of the tape of FIG. 5. [Figure 7a] 1 is a perspective view of a sheath for receiving a measurement device according to one embodiment of the present invention, showing the faces of the sheath. [Figure 7b]FIG. 7b is a view similar to FIG. 7a, showing the opposite side of the sheath. [Figure 8] FIG. 2 is a cross-sectional view of the measurement device of FIG. 1 in a worn configuration. [Figure 9] 1 is a schematic diagram of a measurement and determination system according to an embodiment of the present invention, the device being in a worn configuration; [Figure 10] 1 is a partial perspective view of a variant of an embodiment of a device according to the invention in an unworn configuration; [Figure 11] FIG. 13 is a partial perspective view of another embodiment variant of the device according to the invention in an unworn configuration. [Figure 12] 13 is a partial perspective view of yet another embodiment variant of the device according to the invention in an unworn configuration. FIG. [Figure 13a] 1 is a schematic diagram of a first side of a measurement device according to another embodiment in an unworn configuration. [Figure 13b] FIG. 13b is a schematic diagram of a second side of the measurement device of FIG. 13a in an unworn configuration. [Figure 13c] FIG. 13b shows the measuring device of FIG. 13a in a worn configuration, in a first position. [Figure 13d] FIG. 13b shows the measuring device of FIG. 13a in a worn configuration, in a second position.

[0078] These embodiments are in no way limiting, and therefore variations of the invention can be considered to include only a selection of features described or illustrated below, apart from other features described or illustrated (even if this selection is separated within a phrase including these other features), if this selection of features is sufficient to provide a technical advantage or to distinguish the invention with respect to the state of the prior art. This selection includes at least one, preferably functional, feature without structural details and / or with only a portion of the structural details, if this portion alone is sufficient to provide a technical advantage or to distinguish the invention with respect to the state of the prior art. DETAILED DESCRIPTION

[0079] 1 to 6 partially show an apparatus 3 for measuring multiple temperatures according to one embodiment of the present invention. In Figures 1-4, the measuring device 3 is shown in its unworn configuration in which, in the illustrated non-limiting examples, the measuring device 3 is substantially flat, and in Figures 8 and 9, the measuring device 3 is shown in its worn configuration in which it is at least partially wrapped onto itself to form at least one cylindrical portion having an axis (Z).

[0080] In the worn configuration, as shown in FIG. 9 , the measuring device 3 at least partially surrounds the arm 100 of the wearer 102 laterally near the armpit 101 corresponding to the wearer's body, such that the axis (Z) of the measuring device 3 is substantially aligned with the axis of the arm 100. In the illustrated embodiment, the measuring device 3 is an arm band that encircles a human arm, either completely or partially depending on the circumference of the arm 100 and the size of the measuring device 3 . The measuring device 3 comprises a first face 31 (visible in FIG. 2) and a second face 32 opposite the first face 31 (visible in FIG. 1). In the worn configuration, as seen in FIG. 8, the first surface 31 of the measuring device 3 is rolled towards the axis (Z) and the first surface 31 is in contact with the skin of the arm 100 of the wearer.

[0081] 1-4, the measuring device 3 may be in the form of an elongated band in a longitudinal direction (X) that, in the worn configuration, corresponds substantially to the perimeter of the measuring device 3 and that around the arm 100. In embodiments in which the measuring device 3 is substantially flat in the unworn configuration, the faces 31, 32 lie substantially in a plane parallel to (X,Z) in the unworn configuration. Axis (Y) is defined as being perpendicular to axes (X) and (Z). The three axes (X), (Y), and (Z) are mutually orthogonal.

[0082] The band has a longitudinal central axis 10, a lateral central axis 11, an upper edge 12, and a lower edge 13 (with reference to the position of the measuring device 3 worn by the wearer in a reference anatomical position). The terms "upper edge" and "lower edge" are used for ease of explanation and are provided herein with reference to the figures, in particular FIG. 9, in which the measuring device 3 is worn on the wearer's right arm. However, the same measuring device 3 can be placed on the wearer's left arm in a reversed placement, in which case the upper edge is located below the lower edge.

[0083] According to the invention, it may be desirable to place the measuring device on the wearer's left arm. The device can advantageously be rolled along the anterior-posterior axis of the body to such an extent that the upper edge is located below the lower edge. The advantage of this option is that the placement of the device on the left arm is exactly symmetrical to the placement on the right arm in the sagittal plane of the body, which is a real ergonomic and cognitive advantage for the caregiver, and in addition all sensors are positioned in a place on the body that is symmetrical to the previous one in the sagittal plane of the body.

[0084] Alternatively, the device could be passed from the right arm to the left arm without wrapping, but of course wrapping itself around the Z axis to position the skin sensor centered opposite the brachial artery in the left arm. This alternative offers less benefit than the previous alternative for consistency of results, since the sensor is potentially not positioned in a symmetrical zone of the body in the sagittal plane. The band has a length L in a direction (X) preferably greater than 12 cm, better still greater than 15 cm or even greater than 20 cm, and a width l in a direction substantially parallel to the axis (Z) of the cylinder in the worn configuration, of about 3 cm.

[0085] As can be seen in Figures 3, 5 and 6, the measuring device 3 comprises a tape 15 elongated in a direction (X) and a case 20 which may be formed of a base 21 and a cover 22 which may be assembled to the base 21. The case 20 includes an electronic board 23 and a battery 24 connected to the elongated tape 15. The tape 15 has a thickness e in a direction (Y) as shown in Figure 4.

[0086] According to the invention, the measuring device 3 comprises a plurality of skin temperature sensors 33, more specifically at least three skin temperature sensors 33, configured to measure the skin temperature of the wearer 102. The skin temperature sensors 33 are positioned on or near the first surface 31 of the measuring device 3 and extend over at least a part of the periphery of the measuring device 3 in the worn configuration.

[0087] The at least three skin temperature sensors are positioned in direct contact with the skin of the wearer's arm with no intermediate layer between the at least three skin temperature sensors and the wearer's skin. A first surface of the measuring device is positioned in direct contact with the skin of the wearer's arm without any intermediate layer between the first surface and the skin of the wearer's arm, and at least three skin temperature sensors are placed on this first surface and directed towards the outside of the device 3.

[0088] 2, the measuring device 3 comprises seven skin temperature sensors 33. Naturally, the invention is not limited to this example or to a particular number of sensors. Nevertheless, the higher the number of sensors, the more accurate the skin temperature measurement. Furthermore, the measuring device 3 comprises at least one cavity temperature sensor 34 configured to measure the temperature in or near the armpit 101 of the wearer 102. The cavity temperature sensor 34 is here single and is, without being limited thereto, located on or near the second face 32 of the measuring device 3. The cavity temperature sensor 34 is directed outwards, towards the armpit 101 and is therefore affected by the temperature conditions in the armpit 101 at the particular position of the wearer. Providing several cavity temperature sensors 34 makes it possible to obtain a more accurate measurement of the cavity temperature.

[0089] The at least one cavity temperature sensor is positioned in direct contact with the wearer's underarm without an intermediate layer between the at least one cavity temperature sensor and the wearer's underarm. A second surface of the measuring device is positioned in direct contact with the wearer's underarm without an intermediate layer between the second surface and the wearer's underarm, and at least one cavity temperature sensor is placed on this second surface and directed towards the outside of the device 3. The number of cavity temperature sensors (34) is less than the number of skin temperature sensors (33). In particular, the elongate tape 15 provides support for the skin temperature sensor 33 and the cavity temperature sensor 34 , and also integrates the electronic connections between these sensors and the electronic board 23 .

[0090] 6 the cavity temperature sensor 34 can be seen on an off-center tab, but in the same plane as the skin temperature sensor 33. This configuration allows the tab to be wrapped around 180°, thus allowing the cavity temperature sensor 34 to be placed on the second side 32 of the measurement device 3, and thus on the opposite side of the skin temperature sensor 33.

[0091] The measuring device 3 may also include at least one proximal temperature sensor 35 configured to measure the ambient temperature in the immediate vicinity of the arm 100 of the wearer 102. The proximal temperature sensor 35 is located on or near the second surface 32 of the measuring device 3. Providing several proximal temperature sensors 35 makes it possible to obtain a more accurate measurement of the ambient temperature. At least one proximal temperature sensor is located on the second surface and faces towards the exterior of the device 3 .

[0092] The at least one proximal temperature sensor is arranged in direct contact with the air surrounding the device 3 without an intermediate layer between the at least one proximal temperature sensor and the air. In the unworn configuration, the distance between one of the skin temperature sensors (33) (or one of the skin temperature sensors (33) or a point centrally located on the skin temperature sensor) and at least one proximal temperature sensor (35) (or one of the proximal temperature sensors (35) or a point centrally located on the proximal temperature sensor) is greater than 10 cm (and / or less than 20 cm).

[0093] The measuring device 3 may also include at least one additional physicochemical data sensor 36, such as a photoplethysmograph configured to measure the wearer's heart rate and oximetry, which may be located on or near a first surface 31 of the measuring device 3 (in which case the at least one physicochemical data sensor is placed on the first surface, facing towards the outside of the device 3, and / or positioned in direct contact with the skin of the wearer's arm without having an intermediate layer between the at least one physicochemical data sensor and the skin of the wearer's arm), or on or near a second surface 32 of the measuring device 3 (in which case the at least one physicochemical data sensor is placed on the second surface, facing towards the outside of the device 3, and / or positioned in direct contact with the air surrounding the device 3 without having an intermediate layer between the at least one physicochemical data sensor and the air).

[0094] In practice, the proximal temperature sensor 35 and the additional physicochemical data sensor 36 can be mounted at the level of the case 20 on the cover 22 and base 21, respectively. Further, optionally, the measurement device 3 comprises a galvanometer 37 sensor (comprising two sensors) configured to measure the level of sweat or perspiration secreted by the wearer's body. The case 20 and elongate tape 15 are covered, for example by overmolding, with a sleeve 25 made of a flexible material such as silicone.

[0095] The measuring device 3 is thus flexible and configured to be capable of being transformed from its unworn, e.g. flat, configuration to a cylindrical worn configuration. This transformation is typically performed by winding and curving the central longitudinal axis 10 from a straight shape through a substantially circular shape (or in variants, a circular section, a helix, or a spiral). The measuring device 3 can thus be adapted to the morphology of the wearer and fitted closely to the shape of the arm 100.

[0096] The skin temperature sensors 33 are arranged in a first zone Z33 of the measuring device 3. According to one embodiment, the first zone Z33 is elongated and extends in the longitudinal direction (X) of the measuring device 3. In the embodiment of Fig. 1, the skin temperature sensors 33 are arranged in an aligned manner. According to a variant not shown, the skin temperature sensors 33 can be arranged in a staggered manner in said first zone Z33. As an example, the length L33 of the first zone Z33 may be about 5 cm. One or more cavity temperature sensors 34 are arranged in a second zone Z34 of the measuring device 3.

[0097] A first zone Z33 of the skin temperature sensor 33 and a second zone Z34 of one or more cavity temperature sensors 34 can be arranged completely opposite each other and project in a plane (X, Z), as in the case of Fig. 1. As can be seen in Fig. 1, the cavity temperature sensor 34 can be arranged substantially centrally opposite this first zone Z33 in the longitudinal direction X.

[0098] According to another variant, the first zone Z33 of the skin temperature sensor 33 and the second zone Z34 of the one or more cavity temperature sensors 34 can be arranged only partially opposite each other, protrude into the plane (X, Z) and have a certain overlap. According to yet another variant, the first zone Z33 of the skin temperature sensor 33 and the second zone Z34 of the one or more cavity temperature sensors 34 can be separated. They can preferably project substantially adjacently in the plane (X, Z), as in the case of FIG. The proximal temperature sensor 35 is preferably positioned substantially diametrically opposite the cavity temperature sensor 34 in the worn configuration of the measurement device 3, as seen in FIG.

[0099] The present invention also provides a sheath 27, shown in Figures 7a and 7b, for receiving the measuring device 3. This sheath 27, made from a flexible material, protects the measuring device 3, meets hygiene considerations (the sheath may be disposable or washable) and allows for easy positioning of the measuring device 3 on the wearer 102.

[0100] The sheath 27 preferably has a window 28 facing each of the sensors 33, 34, 35, 36, 37 of the receiving measuring device 3, or a single window facing a group of sensors. Furthermore, the sheath may have, on its surface 29 intended to be in contact with the arm 100 of the wearer 102, at least one adhesive portion 30 intended to be attached to the arm 100 of the wearer 102. For example, the adhesive portion 30 comprises an adhesive layer covered by at least one band that can be peeled off before positioning of the measuring device.

[0101] 9 shows a system 1 for determining a human core body temperature. The system 1 comprises a measuring device 3 and a processing unit 2 configured and / or programmed to determine the core body temperature of a wearer 102 of the measuring device 3 based on temperature data measured by said measuring device 3.

[0102] The processing unit 2 comprises, for example, analogue and / or digital electronic circuits, and / or a central processing unit of a computer, and / or a microprocessor, and / or software means. The processing unit 2 and the measuring device 3 are configured and / or programmed to communicate with each other, in particular the measuring device 3 is configured to transmit the measured temperature data to the processing unit 2, which receives the measured temperature data and analyses them and, based on these items of data, determines the core body temperature of the wearer of the measuring device 3. To communicate with the processing unit 2, the measuring device 3 comprises a transmitter 38 arranged to transmit items of measured temperature measurement information to a receiver 41 of the processing unit 2, for example as shown in Fig. 9. The transmitter 38 may be an antenna for transmitting the temperature measurement information.

[0103] Furthermore, the measuring device 3 may comprise an element 39 for displaying the determined core body temperature, which display element 39 may be an indicator screen and / or one or more light indicators, for example coloured or colourless electroluminescent diodes. The core body temperature determined by the processing unit 2 is communicated to the measuring device 3, in particular to the display element 39, by a transmitter / receiver transmitter 38. In particular, the transmitter 38 and the display element 39 may be located on or in the case 20 of the measuring device 3 .

[0104] According to an embodiment, the processing unit 2 comprises at least one memory 22, preferably a cache memory allowing to collect temperature data measured at regular or irregular time intervals by the measuring device and to store them. Furthermore, the processing unit 2 may comprise a receiver 41 arranged to cooperate with a transmitter 38, for example a transmitting antenna, positioned in the measuring device 3. The receiver 41, which is preferably also a transmitter, is arranged to communicate with the memory 22 of the processing unit 2 in order to store the received temperature data.

[0105] The system 1 according to the invention may further comprise a display device 4 arranged to display at least the core body temperature determined by the processing unit 2 on the basis of the measurements produced by the measuring device 3 . In a highly integrated version of the electronics it is possible to provide that the processing unit 2 is integrated into the measuring device 3 . Different arrangements of the sensors are shown in Figures 10-12. The first configuration is shown in FIG. According to this arrangement, the skin temperature sensor 33 is aligned along an axis (Y) on the first face 31 on an axis 10 a that corresponds to the projection of the central longitudinal axis 10 of the measuring device 3 .

[0106] Furthermore, several cavity temperature sensors 34 (for example three) can be provided facing the zone Z33 in which the skin temperature sensor 33 is found. The cavity temperature sensors 34, shown in dotted lines, can be aligned on the second face 32 along an axis (Y), on an axis 10b corresponding to the projection of the central longitudinal axis 10 of the measuring device 3.

[0107] Thus, when projected along axis (Y) in a projection plane parallel to (X, Z), zones Z33 and Z34 are at least partially opposite each other, i.e. at least partially overlapped. The overlapping need not be complete. For example, as can be seen in FIG. 10, zone Z34 extends beyond zone Z33 along axis (X) on both sides of zone Z33. The reverse position, i.e. zone Z33 extends beyond zone Z34 along axis (X), can also be envisaged.

[0108] For example, when viewed in the projected plane, there may be a first cavity temperature sensor 34 positioned centrally relative to the first zone Z33 along the axis (X), and two cavity temperature sensors 34 positioned on either side and immediately adjacent to the ends of the first zone Z33. Furthermore, the proximal temperature sensors 35 (e.g., two in number) can be aligned on the above-mentioned axis 10b. The proximal temperature sensors are, for example, arranged at one end of the measuring device 3 along the axis (X), and the zones Z33 and Z34 are arranged at the other end of the measuring device 3 along the axis (X). Naturally, the invention is not limited to this arrangement.

[0109] In this "wearing configuration" of the measurement device (placed on the user's arm) which includes proximal temperature sensors located in two sub-groups at the two ends of the measurement device, the two sub-groups are brought close to each other, clustered or overlapping, forming only a single group. An alternative arrangement is shown in FIG.

[0110] According to this arrangement, the group formed by the zones Z33, Z34 and the sensors 33, 34 is identical to that described above with reference to figure 10, whereas in the embodiment of figure 11 this group is placed so as to be substantially centred on the measuring device 3 along the axis (X). At each end of the measuring device 3, a proximal temperature sensor 35 is provided. The two proximal temperature sensors 35 are also located on the above-mentioned axis 10b. Their location at the two ends of the measuring device 3 in the unworn configuration means that in the worn configuration, the two proximal temperature sensors 35 are both positioned substantially diametrically opposite the center of the zone Z33, insofar as the measuring device 3 is positioned on the arm whose diameter forms part of the area in which the measuring device 3 is provided and dimensioned.

[0111] A third configuration is shown in FIG. In this arrangement, the skin temperature sensor 33 is configured as in Fig. 10. An additional physicochemical data sensor 36 and at least two sensors 37 of at least one galvanometer are also provided on the first face 31 and substantially on the axis 10a, located on either side of the additional physicochemical data sensor 36. The sensor groups 36, 37 can be located along the axis (X) near the end of the measuring device 3 opposite the end where the zone Z 33 is located.

[0112] One or more cavity temperature sensors 34, here two in number, are also provided. In the embodiment of Figure 12, cavity temperature sensors 34 are located on second face 32 and aligned on axis 10c that is parallel to axis 10b and offset from axis 10b along axis (Z). Axis 10c can be offset from axis 10b in the direction of bottom edge 13.

[0113] Thus, when projected along the axis (Y), in a projection plane parallel to (X, Z), the zones Z33 and Z34 are offset from each other in the direction (Z). Depending on the dimensions of the sensors 33, 34 and the offset between the axes 10b and 10c, there may be a certain overlap between the zones Z33 and Z34 along the axis (Z), or the zones Z33 and Z34 may be adjacent along the axis (Z), or the zones Z33 and Z34 may be spaced apart from each other along the axis (Z). Furthermore, in the embodiment shown in FIG. 12, the second zone Z34 is also offset with respect to the first zone Z33 along the axis (X). For example, looking at said projection plane and considering only the relative positioning projecting on the axis (X), in the direction of the sensors 36, 37, there may be a first cavity temperature sensor 34 positioned at the level of the first zone Z33, and a second cavity temperature sensor 34 positioned at a distance from the zone Z33, although not necessarily centrally, unlike the arrangement in FIG. 10. This placement is non-limiting.

[0114] The measurement device 3 may also include one or more proximal temperature sensors 35. In the illustrated embodiment, a single proximal temperature sensor 35 located on axis 10c is provided at the end of the measurement device 3 opposite zone Z33 along axis (X). Reference is now made to figures 13a to 13d, which show another embodiment of the invention. According to this embodiment it is possible to combine two complete sets of sensors on one and the same measuring device for two different positions on the wearer's arm. The choice of position is established the moment the measuring device is placed on the wearer's arm, according to which one side or the other is placed in contact with the skin.

[0115] As shown diagrammatically in Figures 13a and 13b, the measuring device 3 comprises a first set of sensors S1 and a second set of sensors S2. The first set of sensors S1 are at least three skin temperature sensors 33-1 positioned on or near a first face 31 of the measuring device in a first zone Z33-1 and extending over a first length L33-1, the at least three skin temperature sensors of the first set being arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the at least three skin temperature sensors of the first set and the skin of the wearer and / or the first face of the measuring device being arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the first face and the skin of the wearer's arm, the at least three skin temperature sensors of the first set being placed on this first face and directed towards the outside of the device 3; at least one cavity temperature sensor 34-1 arranged on or near the second face 32 of the measuring device 3 in a second zone Z34-1, where the at least one cavity temperature sensor of the first set is arranged in direct contact with the wearer's underarms without an intermediate layer between the at least one cavity temperature sensor of the first set and the wearer's underarms and / or the second face of the measuring device is arranged in direct contact with the wearer's underarms without an intermediate layer between the second face and the wearer's underarms, and the at least one cavity temperature sensor of the first set is placed on this second face and at least one cavity temperature sensor 34-1 directed towards the outside of the device 3; a proximal temperature sensor 35-1 preferably located on or near the second face 32 of the measuring device 3; Equipped with.

[0116] Moreover, as already explained, the zones Z33-1 and Z34-1 are at least partially opposite or substantially adjacent to each other and project in a plane perpendicular to the first and second faces 31,32. The second set of sensors S2 are At least three skin temperature sensors 33-2 are positioned on or near the second face 32 of the measuring device 3 in a first zone Z33-2 and extend over a second length L33-2, advantageously different from the first length L33-1. In the illustrated embodiment, L33-2 is less than L33-1. Furthermore, there may be different spacings between adjacent skin temperature sensors, and accordingly these sensors belong to a first set S1 or to a second set S2, with at least three skin temperature sensors of the second set being arranged in direct contact with the skin of the wearer's arm without having an intermediate layer between the at least three skin temperature sensors of the second set and the skin of the wearer, and / or the second face of the measuring device is arranged in direct contact with the skin of the wearer's arm without having an intermediate layer between the second face and the skin of the wearer's arm, with at least three skin temperature sensors of the second set being placed on this second face and at least three skin temperature sensors being directed towards the outside of the device 3. at least one cavity temperature sensor 34-2 arranged on or near the first face 31 of the measuring device 3 in a second zone Z34-2, where at least one cavity temperature sensor of the second set is arranged in direct contact with the wearer's underarms without an intermediate layer between the at least one cavity temperature sensor of the second set and the wearer's underarms, and / or the first face of the measuring device is arranged in direct contact with the wearer's underarms without an intermediate layer between the first face and the wearer's underarms, and at least one cavity temperature sensor of the second set is located on this first face and at least one cavity temperature sensor 34-2 facing towards the outside of the device 3; a proximal temperature sensor 35-2 preferably located on or near the first face 31 of the measuring device 3; Equipped with.

[0117] The device is configured to use or activate a single set of sensors at a time from the first set of sensors and the second set of sensors, where a single set of sensors at a time from the first set of sensors and the second set of sensors is activated to measure at least one temperature, while other sets of sensors from the first set of sensors and the second set of sensors are inactive and not used to measure one or more temperatures.

[0118] The device 3 and / or the system 1 (more specifically the electronic and / or software means 23 and / or the processing unit 2) determine which face of 31 or 32, respectively, faces the user's arm and which face of 32 or 31, respectively, faces the user's armpit, activating a first set of sensors and deactivating a second set of sensors when surface 31 is pointing towards the user's arm and surface 32 is pointing towards the user's armpit; When surface 32 is facing the user's arm and surface 31 is facing the user's armpit, activate the second set of sensors and deactivate the first set of sensors. The device is arranged and / or programmed to:

[0119] the device 3 and / or the system 1 (more particularly the electronic and / or software means 23 and / or the processing unit 2) assigns, from among the surfaces 31 and 32, the surface facing the armpit of the user as being the surface; has temperature fluctuations measured (by sensors 33-1, 33-2, 34-1, and / or 34-2) with a higher amplitude and / or a higher temporal frequency (because in its normal use the arm is periodically separated from the armpit while device 3 remains fixed to the arm); and / or having the highest temperature measured (by sensors 33-1, 33-2, 34-1, and / or 34-2); The device is arranged and / or programmed to:

[0120] Thus, the method according to the invention implemented in the device 3 and / or the system 1 (more specifically by the electronic and / or software means 23 and / or the processing unit 2) involves determining which side of 32 or 31, respectively, faces the user's arm and which side of 32 or 31, respectively, faces the user's armpit, Activating a first set of sensors and deactivating a second set of sensors when surface 31 faces the user's arm and surface 32 faces the user's armpit; Activating the second set of sensors and deactivating the first set of sensors when surface 32 is facing the user's arm and surface 31 is facing the user's armpit; Preferably, the assignment of the face facing the armpit of the user as being a face from among faces 31 and 32; having temperature variations measured (by sensors 33-1, 33-2, 34-1 and / or 34-2) with a higher amplitude and / or a higher temporal frequency (because in its normal use the arm is periodically separated from the armpit whilst device 3 remains fixed to the arm); and / or Having the highest temperature measured (by sensors 33-1, 33-2, 34-1, and / or 34-2) There is a decision.

[0121] As shown in the figure, the number of cavity temperature sensors (34-1) in the first set is less than the number of skin temperature sensors (33-1) in the first set; As shown in the figure, the number of cavity temperature sensors (34-2) in the second set is less than the number of skin temperature sensors (33-2) in the second set. Moreover, as already explained, the zones Z33-2 and Z34-2 are at least partially opposite or substantially adjacent to each other and project in a plane perpendicular to the first and second faces 31,32.

[0122] It should be noted that in Fig. 13a, zones Z34-2 and Z33-1 are offset relative to each other in direction Z for clarity of the drawing. However, this arrangement should not be considered limiting, and zones Z34-2 and Z33-1 can be arranged at least partially overlapping. The same comments apply to Fig. 13b. Moreover, the number of sensors in a given zone, their relative separation, and the relative placement of the different zones of sensors are shown as non-limiting examples.

[0123] Advantageously, the axis of zone Z33-1 and the axis of zone Z34-2 can be superimposed in order to have one or more temperature sensors common to the two zones. Similarly, the axis of zone Z33-2 and the axis of zone Z34-1 can be superimposed in order to have one or more temperature sensors common to the two zones. These configurations are comparable in terms of the accuracy of the values ​​obtained, but have the real advantage from an economic point of view that fewer sensors are required, since the same information is captured. Additionally, although sensors 36, 37 are not shown, this does not necessarily mean that they are not present. In other words, the temperature sensors of the two layouts are combined in the measuring device 3 of Figures 13a to 13d, so that one and the same measuring device 3 can be adapted to a wide range of arm diameters.

[0124] The measuring device 3, shown in a flat unworn configuration in Fig. 13a and Fig. 13b, can be wrapped in its worn configuration according to two different positions: In a first position, shown in Fig. 13c, the first side 31 is oriented towards the arm of the wearer. In this case, the first set of sensors S1 is used; in a second position, shown in Fig. 13d, the second side 32 is oriented towards the arm of the wearer. In this case, the second set of sensors S2 is used.

[0125] Thus, a measuring device 3 in a first position in Fig. 13c can, for example, be intended for an arm having a circumference between 20 cm and 28 cm, and the same measuring device 3 can be wrapped in a second position shown in Fig. 13d, advantageously equipped on an arm whose circumference is between 28 cm and 40 cm. The arrangement of the sensors S1, S2 in each of the sets is adapted to fit these two morphological ranges.

[0126] Thus, when the caregiver is dealing with a patient whose arm has a circumference falling within a first range of circumference values, the sensor will choose to be worn on the skin side with the first side 31, and when the caregiver is dealing with a patient whose arm has a circumference falling within a second range of circumference values, the sensor will choose to be worn on the skin side with the second side 32. In the two positions the measuring device 3 is perfectly adapted to the wearer and provides measurements with the required accuracy.

[0127] Of course, it is possible to optimize the number of sensors and use temperature sensors embedded in the surface of the first ambient area to perform the measurements required for the second ambient area. It should be noted that these two sets of sensors S1, S2 coexist and are independent on the measuring device 3. It is possible, for example, to provide a device in which one surface is placed at the top of the armpit and one surface a little lower, or one surface is placed specifically on the left armpit and one surface is placed specifically on the right armpit, etc.

[0128] Skin temperature measurements must be very accurate and very reliable, therefore a specialized temperature sensor 33 for human health with an integrated high resolution analog-to-digital converter is preferred. The requirements for accurate cavity temperature measurement are lower than for skin temperature measurement, so it is possible to choose simpler sensors 34 such as thermocouples or thermistors, which are easier to implement and have lower costs. For simplicity, sensors 33, 34, and 35 are identical, and in this description, specifically, each temperature sensor designated 33, 34, 35 is a temperature sensor designated "MAX30205 Human Body Temperature Sensor" manufactured by MAXIM.

[0129] An embodiment of a method according to the invention for determining the core body temperature of a human being, implemented in a system 1 as described above, including any variant of a device 3 as described above, comprises the steps of: a) measuring at least one skin temperature at a time t or over a period p by at least three skin temperature sensors 33 of a determination system according to the invention; b) measuring at least one cavity temperature at a time t or over a period p by means of at least one cavity temperature sensor 34 of a measurement device of the measurement and determination system according to the invention; c) the measuring device 3 sends the temperature data measured in steps a) and b) via a transmitter 38 to a receiver 41 equipped with a processing unit 2 of the measuring and determination system according to the invention; d) the receiver 41 of the processing unit receives the measured temperature data and transmits it to the memory 22 of the processing unit, where the temperature data is stored; The processing unit 2 compares the skin temperature data for each sensor 33 and determines the wearer's skin temperature for each sensor 33 during time t or period p, for example using an average of the temperatures measured for that sensor 33; The processing unit 2 performs a comparison for one or each cavity temperature sensor 34 and determines the cavity temperature for one or each sensor 34, for example using an average of the temperatures measured for each sensor 34, during a time t or period p. Steps and e) based on the items of temperature data held for each skin temperature sensor 33 and one or each cavity temperature sensor 34, over time t or at least one period p, the processing unit 2 applies a decision model, for example using a correspondence table and / or based on a forest of decision trees and / or a neural network, to determine the wearer's core body temperature using the temperature data for each sensor during time t or period p, or a set of data corresponding to the temperature data for each sensor collected during a rolling observation period P; Includes.

[0130] The method may include step f), performed in parallel with steps a) and / or b) and / or subsequent steps a) and b), consisting of measuring at least one proximal temperature at time t or over a period p. In this case, step d) ends with processing of the proximal temperature measurements with a view to obtaining a single value for one or each proximal temperature sensor 35. Thus, for one or each proximal temperature sensor 35, processing unit 2 compares the values ​​and determines the proximal temperature for this sensor 35 during time t or period p, for example using an average of the measured temperatures for each sensor 35. Processing e) then integrates this data or these items of data in addition to other temperature values ​​to determine the core body temperature.

[0131] An embodiment of a method according to the invention for determining the core body temperature of a human being, implemented in a system 1 as described above including any variant of a device 3 as described above, comprises the following steps: Step a) above. Step a' of determining a single skin temperature value, in particular by selecting the highest value among the skin temperatures from or measured by at least three skin sensors 33 of the determination system according to the invention, step a' is performed by the measuring device 3 or the processing unit 2. Step b above. Step b' of determining a single cavity temperature value, in particular by selecting the highest value among the cavity temperatures measured from or by at least one cavity temperature sensor 34 of a measuring device of the measuring and determination system according to the present invention, step b' is performed by the measuring device 3 or the processing unit 2.

[0132] A step FFF of measuring at least one proximal temperature at a time t or over a period p by means of at least one proximal temperature sensor 35 of the measurement device of the measurement and determination system according to the invention. Step FFF' of determining a single proximal temperature value, in particular by selecting the highest value among the proximal temperatures from or measured by at least one proximal temperature sensor 35 of a measuring device of the measuring and determination system according to the present invention, step FFF' is carried out by the measuring device 3 or the processing unit 2.

[0133] Based on the single skin temperature value determined in step a' and the single cavity temperature value determined in step b', and the single proximal temperature value determined in step FFF', processing unit 2 applies a decision model, for example using a correspondence table and / or based on a forest of decision trees and / or a neural network, to determine the wearer's core body temperature using a single item of skin temperature, cavity temperature, and proximal temperature data collected during time t or period p, or a set of data corresponding to skin temperature, cavity temperature, and proximal temperature data during a rolling observation period P.

[0134] The core body temperature may be determined by the processing unit 2 as a function of additional parameters resulting from one or more additional physicochemical data sensors, as described above. Preferably, the determination of core body temperature may be made based on the measurements made in steps a), b), f) and based on data characterizing physiological arousal, said data being measured by a photoplethysmograph and / or a galvanometer.

[0135] Even more preferably, the determination of core body temperature can be made based on the measurements made in steps a), b), f) and based on data characterizing physiological arousal and based on positioning data measured, for example by a three-axis accelerometer. Preferably, the determination of core body temperature may be performed based on measurements made during a preferably rolling period P, in which a series of steps a), b) and f) are performed and a set of data characterizing physiological arousal is collected over this same period P.

[0136] According to a feature of the invention, after the wearer's core body temperature has been determined over a time t or at least one period p, the processing unit 2 can instruct the display device 4 to display the determined core body temperature during step g). Based on the determined core body temperature, the processing unit 2 can be configured and / or programmed to determine a state of the wearer during step h), for example by correlating the measured core body temperature with a state based on a database or a nomogram integrated in the memory of the processing unit 2. A state of the wearer means for example a healthy state, a fever state, a critical state.

[0137] According to a feature of the invention, the wearer's condition may be communicated by the processing unit 2 to a display device 4 which displays the wearer's condition during step i). During each measurement step, the device 3 is preferably in its worn configuration at least partially surrounding the arm 100 of the wearer 102. Preferably, near the corresponding armpit 101 on the body of the wearer 102, and / or Preferably, the Z-axis of the measuring device 3 is substantially aligned with the axis of the arm 100, and / or Preferably, the first surface 31 of the measuring device 3 is in contact with the skin of the arm 100 of the wearer 102. It is worn by a user 102 . The value of p is preferably the same for sensors 33 and / or 34 and / or 35 . The value of P is different from the value of p. The value of P is greater than the value of p. The value of P is preferably at least 3 times greater than the value of p, preferably at least 5 times greater than the value of p, preferably at least 10 times greater than the value of p. The value of p is preferably 1 second or more, preferably 5 seconds or more, preferably 10 seconds or more. The value of P is preferably greater than or equal to 30 seconds, preferably greater than or equal to 1 minute.

[0138] Typically, the acquisition frequency chosen is 1 Hz for all temperature sensors. For each temperature sensor, a value is sampled every 30 seconds, so p=30''. The rolling period P chosen is 5 minutes, in other words 10 periods p are used, so that to infer the median temperature value, 10 value records are used for each sensor. A predictive algorithm can be added to the inference algorithm, which aims to predict temperature values ​​for the next few minutes, in order to show the caregiver general trends observed to help him or her anticipate what actions to take. Naturally, the invention is not limited to the embodiments described and represented in the attached drawings: modifications are possible, particularly in terms of the configuration of the various elements or by substituting equivalent techniques, without going beyond the scope of protection of the invention.

Claims

1. A device (3) for measuring a plurality of temperatures for the purpose of determining a core body temperature of a human being (102), the human being wearing the device (3), the device (3) having a first surface (31) and a second surface (32) opposite the first surface (31), the device (3) being configured such that the device (3) can be at least partially wrapped around the human being itself and into a worn configuration forming at least one cylindrical portion having an axis (Z), the first surface (31) being: said device (3) is wound towards said axis (Z) such that, in its worn configuration, said device (3) is intended to at least partially surround an arm (100) of said wearer (102) in the vicinity of a corresponding armpit (101) of the body of said wearer (102), such that said axis (Z) of said device (3) is substantially coincident with the axis of said arm (100), said first surface (31) of said device (3) is then in contact with the skin of said arm (100) of said wearer (102), said device (3) being at least three skin temperature sensors (33) configured to measure a skin temperature of the wearer (102), the skin temperature sensors (33) being positioned on the first face (31) of the device (3) in a first zone (Z33) of the device (3) and extending substantially over at least a portion of the periphery of the device (3) in the worn configuration; at least one cavity temperature sensor (34) configured to measure the temperature of the underarm (101) of the wearer (102), the cavity temperature sensor (34) being arranged on the second surface (32) of the device (3) in a second zone (Z34) of the device (3); Equipped with The first zone (Z33) of the skin temperature sensor (33) and the second zone (Z34) of the one or more cavity temperature sensors (34) are arranged at least partially opposite or substantially adjacent to each other and project in a plane perpendicular to the first and second faces (31, 32). It is characterized by: the device (3) being adapted to be able to be placed in an unworn configuration that is substantially flat; The device (3) also comprises at least one proximal temperature sensor (35) configured to measure an ambient temperature in the immediate vicinity of the arm (100) of the wearer (102), the proximal temperature sensor (35) being located on or near the second surface (32) of the device (3); and The device (3) is also characterized in that in the unworn configuration, the distance between the skin temperature sensor (33) and the at least one proximal temperature sensor (35) is greater than 10 cm. Device (3).

2. 2. The device (3) according to claim 1, characterized in that the number of said cavity temperature sensors (34) is less than the number of said skin temperature sensors (33).

3. the first surface of the device (3) is arranged in direct contact with the skin of the wearer's arm without an intermediate layer between the first surface and the skin of the wearer's arm, and the at least three skin temperature sensors are placed on this first surface and directed towards the outside of the device (3); The second surface of the device (3) is arranged to be in direct contact with the underarm of the wearer without an intermediate layer between the second surface and the underarm of the wearer, and the at least one cavity temperature sensor is located on this second surface and is directed toward the exterior of the device (3).

3. Apparatus (3) according to claim 1 or 2, characterized in that

4. The device (3) according to any one of claims 1 to 3, characterized in that in said wearing configuration, said device (3) in said wearing configuration extends at an angle of at least 90°.

5. A device (3) according to any one of claims 1 to 4, characterized in that it is flexible and configured so as to be capable of being transformed between an unworn configuration and said worn configuration by rolling.

6. The device (3) of any one of claims 1 to 5, characterized in that the proximal temperature sensor (35) is angularly offset by at least 90° relative to the at least one cavity temperature sensor (34) in the worn configuration of the device (3).

7. Device (3) according to any one of claims 1 to 6, characterised in that it also comprises at least one additional physicochemical data sensor (36).

8. The device (3) according to any one of claims 1 to 7, characterized in that the first zone (Z33) in which the skin temperature sensors (33) are arranged is elongated and extends in the longitudinal direction of the device (3), and the skin temperature sensors (33) are arranged in alignment or in a staggered manner in the first zone (Z33).

9. 9. The device (3) according to claim 8, characterized in that the at least one cavity temperature sensor (34) is arranged opposite the first zone (Z33) of the skin temperature sensor (33) in the longitudinal direction.

10. In said wearing configuration, it is in the form of an elongated band in a longitudinal direction (X) substantially corresponding to the circumferential line of the device (3), said band comprising: A length (L) in the longitudinal direction (X) exceeding 12 cm; a width (l) of less than 6 cm in a direction substantially parallel to the axis (Z) of the cylindrical portion in the worn configuration; having The band has a central longitudinal axis (10), a central lateral axis (11), an upper edge (12), and a lower edge (13). A device (3) according to any one of claims 1 to 9, characterized in that

11. 11. The device (3) according to claim 10, characterized in that the skin temperature sensor (33) and / or the at least one cavity temperature sensor (34) are arranged substantially along the central longitudinal axis (10) of the band.

12. 11. The device (3) according to claim 10, characterized in that the skin temperature sensor (33) and / or the at least one cavity temperature sensor (34) are offset in the direction of the upper edge (12) relative to the longitudinal central axis (10) of the band.

13. an elongate tape (15) supporting said skin temperature sensor (33) and said at least one cavity temperature sensor (34); a case (20) including an electronic board (23) and a battery (24) connected to said elongate tape (15), said case supporting said at least one proximal temperature sensor (35); Equipped with The case (20) and the elongated tape (15) are covered with a flexible material. Device (3) according to any one of claims 1 to 12, characterized in that

14. an elongate tape (15) supporting said skin temperature sensor (33) and said at least one cavity temperature sensor (34); a case (20) including an electronic board (23) and a battery (24) connected to said elongate tape (15), said case supporting said at least one additional physicochemical data sensor (36); Equipped with The case (20) and the elongated tape (15) are covered with a flexible material by overmolding.

8. Apparatus (3) according to claim 7, characterized in that

15. 15. Apparatus (3) according to claim 13 or 14, wherein the flexible material is silicone.

16. A first set of sensors (S1), at least three skin temperature sensors (33-1) positioned on or near the first face (31) of the device (3) in a first zone (Z33-1) of the first set of sensors and extending over a first length (L33-1); at least one cavity temperature sensor (34-1) located on or near the second face (32) of the device (3) in a second zone (Z34-1) of the first set of sensors of the device (3), at least partially facing or substantially adjacent to the first zone (Z33-1) of the first set of sensors and projecting in a plane perpendicular to the first and second faces (31, 32); a first set of sensors including: A second set of sensors (S2), at least three skin temperature sensors (33-2) positioned on or near the second face (32) of the device (3) in a first zone (Z33-2) of the second set of sensors and extending over a second length (L33-2) different from the first length (L33-1); at least one cavity temperature sensor (34-2) located on or near the first face (31) of the device (3) in a second zone (Z34-2) of the second set of sensors of the device (3), at least partially facing or substantially adjacent to the first zone (Z33-2) of the second set of sensors and projecting in a plane perpendicular to the first and second faces (31, 32); a second set of sensors including Equipped with The device (3) is arranged to use or activate a single set of sensors at a time from the first set of sensors and the second set of sensors. A device (3) according to any one of the preceding claims, characterized in that it

17. the number of cavity temperature sensors (34-1) in the first set is less than the number of skin temperature sensors (33-1) in the first set; The number of the cavity temperature sensors (34-2) in the second set is less than the number of the skin temperature sensors (33-2) in the second set.

17. Apparatus (3) according to claim 16, characterized in that

18. 18. An assembly comprising a device (3) according to any one of claims 1 to 17, further comprising a flexible sheath (27) intended to receive said device (3), said flexible sheath (27) having windows (28) facing each of the skin or cavity temperature sensors of said device (3), said flexible sheath (27) having, on its surface (29) intended to be in contact with said arm (100) of the wearer (102), at least one adhesive portion (30) intended to be attached to said arm (100) of the wearer (102).

19. 19. An assembly according to claim 18, characterized in that said adhesive portion (30) comprises an adhesive layer covered by at least one band which can be peeled off before first use.

20. 1. A system for determining a human core body temperature, comprising: A device (3) for measuring multiple temperatures according to any one of claims 1 to 17 or an assembly according to any one of claims 18 or 19, a processing unit (2) configured and / or programmed to determine the core body temperature of the wearer (102) of the device (3) based on temperature data measured by the device (3); A system comprising:

21. 21. A method for determining a human core body temperature implemented by the system of claim 20, comprising the steps of: a) measuring at least one skin temperature at time t or over a period p by the at least three skin temperature sensors of the system; b) measuring at least one cavity temperature at a time t or over a period p by means of the at least one cavity temperature sensor of the device (3) of the measurement and determination system; c) the device (3) sends the temperature data measured in steps a) and b) via a transmitter to a receiver equipped with the processing unit of the measurement and system according to the invention; d) the receiver of the processing unit receives the measured temperature data and transmits it to a memory of the processing unit where the temperature data is stored; the processing unit compares the skin temperature data for each sensor to determine the skin temperature of the wearer for each sensor during a time t or period p; The processing unit performs a comparison for the or each cavity temperature sensor to determine, for the or each sensor, the cavity temperature during time t or period p. Steps and e) based on the items of temperature data held for each skin temperature sensor and the one or each cavity temperature sensor, over a time t or at least one period p, the processing unit determines the core body temperature of the wearer using the temperature data for each sensor during time t or period p, or a set of data corresponding to the temperature data for each sensor collected during a rolling observation period P; A method comprising:

22. 21. The method according to claim 20, further comprising the steps of: after step a), a step a′) of determining a single skin temperature value; After step b), a step b') of determining a single cavity temperature value; determining said core body temperature of said human wearer based on said single skin temperature value determined in step a' and said single cavity temperature value determined in step b'; 22. The method of claim 21 , comprising:

23. 23. A method according to claim 22 implemented by the system of claim 20, comprising: a step FFF of measuring at least one proximal temperature at a time t or over a period p by said at least one proximal temperature sensor (35); a step FFF' of determining a single proximal temperature value; determining said core body temperature of said human wearer based on said single skin temperature value determined in step a', said single cavity temperature value determined in step b', and said single proximal temperature value determined in step FFF'; The method also includes:

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