How to determine frailty

JP7681882B2Active Publication Date: 2025-05-23OKINAWA INST OF SCI & TECH SCHOOL
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Patent Information

Application Number
JP2020168017
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2019-10-03
Filing Date
2020-10-02
Publication Date
2025-05-23
Estimated Expiration
2040-10-02

AI Technical Summary

Benefits of technology

【0008】 本発明のフレイルの判定方法によると、被験者の血液試料中に含まれるエルゴチオネイン(ET)、クレアチン、アセチル-カルノシン、プロリン、1,5-アンヒドログルシトール(1,5-AG)、2-ケト酪酸、s-メチル-エルゴチオネイン(s-methyl-ET)、トリメチル-ヒスチジン(ハルシニン)、オフタル酸(OA)、尿酸、イソロイシン、ロイシン、トリプトファン、メチオニン、又はUDP-グルクロネートの量といった客観的な数値を指標とすることで、より正確かつ簡便にフレイルの判定をすることが可能となる。

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Abstract

To provide a novel method capable of determining frailty simply and accurately.SOLUTION: The present invention is a method for determining frailty using ergothioneine (ET) in a blood sample of a subject as an index. Further, it is preferable to use creatine, acetyl-carnosine, proline, 1,5-anhydroglucitol (1,5-AG), and 2-ketobutyric acid as indexes.SELECTED DRAWING: None
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Claims

1. Ergothioneine (ET) in a blood sample of the subject; and at least one selected from the group consisting of creatine, acetyl-carnosine, proline, 1,5-anhydroglucitol (1,5-AG), 2-ketobutyric acid, s-methyl-ergothioneine (s-methyl-ET), trimethyl-histidine (halcinine), ophthalic acid (OA), isoleucine, and UDP-glucuronate, How to obtain indicators for determining frailty.

2. The method according to claim 1, wherein at least the ergothioneine (ET) and the creatine are used as indicators.

3. The method according to claim 1 or 2, wherein at least the ergothioneine (ET) and the acetyl-carnosine are used as indicators.

4. The method according to any one of claims 1 to 3, wherein at least the ergothioneine (ET) and the proline are used as indicators.

5. The method according to any one of claims 1 to 4, wherein at least the ergothioneine (ET) and the 1,5-anhydroglucitol (1,5-AG) are used as indicators.

6. The method according to any one of claims 1 to 5, wherein at least the ergothioneine (ET) and the 2-ketobutyric acid are used as indicators.

7. At least said ergothioneine (ET), The method according to any one of claims 1 to 6, wherein the s-methyl-ergothioneine (s-methyl-ET), the trimethyl-histidine (halcinine), the ophthalic acid (OA), the isoleucine, or the UDP-glucuronate is used as an indicator.

8. 8. The method of claim 1, further comprising considering at least one score selected from the group consisting of Edmonton frail scale (EFS), Montreal recognition assessment (MoCA-J), and Timed Up and Go Test (TUG).

Citation Information

Patent Citations

  • Method, device, system and kit for determining ageing degree

    JP2019509489A