Liquid oral composition

Abstract

To provide a liquid oral composition that has high antibacterial effect selectively on intraoral pathogenic bacteria, and has a stable appearance.SOLUTION: A liquid oral composition contains (A) an ester compound of a C18-22 unsaturated fatty acid and a polyhydric alcohol, (B) ethanol, (C) polyoxyethylene hardened castor oil with an average number of moles of added ethylene oxides of 40-100 mol, and (D) at least one selected from a sugar alcohol and glycerol. The content of component (C) is 0.1-1.8 mass%.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a liquid oral composition having an excellent selective antibacterial effect against pathogenic bacteria in the oral cavity, particularly periodontal pathogenic bacteria, and having appearance stability.

Background Art

[0002] Many bacteria coexist in the human body, forming a bacterial population called the bacterial flora, which has important functions for maintaining human health. This bacterial flora contains so-called non-pathogenic resident bacteria and pathogenic bacteria including opportunistic infectious bacteria. Usually, the balance of the bacterial flora is maintained, which is a so-called healthy state, and diseases caused by pathogenic bacteria are suppressed. Also, although the bacterial composition varies depending on the body part, the balance of the bacterial composition is disrupted by internal or external factors, and the pathogenic bacteria become dominant and the disease progresses when the homeostasis breaks down. Therefore, for maintaining and promoting health, it is important not only to maintain the homeostasis of the bacterial composition, but also to suppress only pathogenic bacteria and to form a bacterial flora in which non-pathogenic resident bacteria are more dominant and homeostasis is less likely to break down.

[0003] Oral diseases such as dental caries and periodontal disease in the oral cavity also occur when the homeostasis of the oral bacterial flora symbiotic in the oral cavity breaks down and pathogenic bacteria become dominant. Although pathogenic bacteria can be reduced by using a bactericide, the balance of the bacterial flora does not change because the resident bacteria are also reduced. On the other hand, rather than simply sterilizing pathogenic bacteria, maintaining or increasing the proportion of non-pathogenic resident bacteria other than pathogenic bacteria to make the resident bacteria more dominant is more effective in preventing the onset of oral diseases and is important for suppressing the onset or progression of oral diseases. Furthermore, oral bacteria have begun to be shown to potentially be involved in human overall health, such as being reported to be related not only to oral diseases but also to enteritis, Alzheimer's disease, diabetes, etc. Therefore, oral care is important for maintaining a healthy state by maintaining the resident bacteria and maintaining or improving the homeostasis of the oral microbiota, not only for the prevention and treatment of oral diseases but also for the maintenance and promotion of overall health. However, although the bactericides generally used in oral compositions have a certain therapeutic and preventive effect on oral diseases by eliminating pathogenic bacteria through their bactericidal action, their action not only eliminates pathogenic bacteria but also sterilizes and removes other resident bacteria, and even non-pathogenic resident bacteria, so there is also a risk of bacterial substitution syndrome.

[0004] Therefore, a technique for selectively suppressing pathogenic bacteria in the oral cavity and maintaining and forming an oral microbiota mainly composed of resident bacteria is desired. So far, antibodies and the like have been studied as representative techniques, but it is hard to say that sufficient effects have been obtained, and there is room for improvement. As techniques related to maintaining the balance of the oral microbiota, for example, oral antibacterial agents using plant extracts such as pterostilbene and cantharidin (Patent Documents 1, 2: JP 2017-81831 A, JP 2016-113460 A), oral microbiota improvers using dried powders of mushrooms such as Grifola frondosa or their extracts (Patent Document 3: WO 2016 / 043103), growth promoters for oral resident bacteria combining specific lysophosphatidic acid and its derivatives, etc. with phosphatidic acid and its derivatives, etc. (Patent Document 4: JP 2019-001720 A) have been proposed.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

[0006] The present invention has been made in view of the above circumstances, and an object thereof is to provide a liquid oral composition having an excellent selective antibacterial effect against pathogenic bacteria in the oral cavity and having appearance stability. [Means for Solving the Problems]

[0007] As a result of intensive studies to achieve the above object, the present inventors have found that when a liquid oral composition is formulated by combining an ester compound of a specific unsaturated fatty acid and a polyhydric alcohol, ethanol, a specific amount of a specific nonionic surfactant, and a sugar alcohol and / or glycerin, the appearance stability can be maintained even after high-temperature storage, and the ester compound can impart a remarkable selective antibacterial effect against pathogenic bacteria in the oral cavity, particularly periodontal pathogenic bacteria. That is, in the present invention, it has been found that a liquid oral composition containing (A) an ester compound of an unsaturated fatty acid having 18 to 22 carbon atoms and a polyhydric alcohol, (B) ethanol, (C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, and (D) at least one selected from sugar alcohols and glycerin, and having a content of the component (C) of 0.1 to 1.8% by mass has an excellent selective antibacterial effect against pathogenic bacteria in the oral cavity and has appearance stability, and thus the present invention has been completed.

[0008] The applicant has proposed in Japanese Patent Application No. 2019-137704 that an ester compound of an unsaturated fatty acid having 18 to 22 carbon atoms and a polyhydric alcohol selectively antibacterializes pathogenic bacteria in the oral cavity, and further exhibits an action of selectively promoting the growth of indigenous bacteria in the oral cavity, and can be applied to an oral composition as an active ingredient for promoting the growth of indigenous bacteria in the oral cavity and further improving the oral flora. The present inventors further investigated in order to apply the above ester compound to a liquid oral composition. In liquid oral compositions such as mouthwashes, ethanol is generally blended in order to give a refreshing feeling in the oral cavity after use as an element such as the actual feeling of the oral cavity purification function which is a basic function. When the component (A) is blended in a liquid oral composition in which the component (B) is blended, the above action by the component (A) is exhibited, and a selective antibacterial effect against pathogenic bacteria in the oral cavity can be imparted. However, on the other hand, turbidity occurs after storage at high temperature, and there is a problem that the appearance stability is impaired. By simply adding a general nonionic surfactant as a solubilizer, for example, polyoxyethylene hydrogenated castor oil, the problem regarding the above appearance stability could not be improved without impairing the selective antibacterial effect by the component (A). In contrast, in the present invention, when the components (C) and (D) are combined with the components (A) and (B), within a specific range of the amount of the component (C), all of the above problems peculiar to the combined system of the components (C) and (D), the component (A), and further the combined system of the components (A) and (B) are solved, and the appearance stability can be ensured even after storage at high temperature without impairing the selective antibacterial effect against oral pathogenic bacteria by the component (A), and both the imparting of the selective antibacterial effect and the ensuring of the appearance stability can be achieved. Therefore, according to the present invention, it is possible to provide a liquid oral composition containing ethanol that suppresses the occurrence of turbidity even after storage at high temperature, ensures appearance stability even when prepared into a mouthwash having a clear appearance, and gives an excellent selective antibacterial effect against pathogenic bacteria in the oral cavity, particularly periodontal pathogenic bacteria. The effects of the present invention are specifically obtained when the components (A), (B), (C) and (D) are combined and the amount of the component (C) is within a specific range. As shown in the comparative examples described later, Comparative Example 3 in which components (A) and (B) and component (D) are blended and component (C) is not blended has poor appearance stability after storage at 50°C for 1 month even when an inappropriate polyoxyethylene hydrogenated castor oil is blended. In Comparative Examples 4 and 5 in which components (A), (B), and (C) are blended and component (D) is not blended, even when 1,3-butylene glycol, a polyhydric alcohol, is further blended, the selective antibacterial effect against periodontal pathogenic bacteria is inferior. Further, in Comparative Examples 1 and 2 in which components (A), (B), (C), and (D) are blended but component (C) is blended in an inappropriate amount, the appearance stability or the selective antibacterial effect against periodontal pathogenic bacteria is inferior. In contrast, the liquid oral composition (Example) in which components (A), (B), (C), and (D) of the present invention are blended was excellent in the selective antibacterial effect against periodontal pathogenic bacteria and appearance stability. Ester compounds of unsaturated fatty acids and polyhydric alcohols are known to be used as surfactants for oral compositions and some have antibacterial effects (Patent Documents 5 to 7; JP-A-2012-144490, JP-A-2009-155257, JP-A-2012-116827). However, the present invention relates to the imparting of a remarkable selective antibacterial effect against pathogenic bacteria in the oral cavity and the improvement of appearance stability by the combination of components (A), (B), (C), and (D) in a liquid oral composition, with the amount of component (C) within a specific range.

[0009] Therefore, the present invention provides the following liquid oral composition. [1] (A) An ester compound of an unsaturated fatty acid having 18 to 22 carbon atoms and a polyhydric alcohol, (B) Ethanol, (C) Polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and (D) At least one selected from sugar alcohols and glycerin A liquid oral composition, characterized in that it contains the above components and the content of component (C) is 0.1 to 1.8% by mass. [2] The liquid oral composition according to [1], wherein the component (A) is at least one selected from glyceryl oleate, glyceryl linoleate, polyglyceryl oleate having a degree of polymerization of glycerin of 10 or less, sorbitan oleate, sucrose oleate, sucrose erucate, polyethylene glycol oleate having an average number of added moles of ethylene oxide of 10 or less, polyoxyethylene sorbitan oleate having an average number of added moles of ethylene oxide of 10 or less, and polyoxyethylene glyceryl oleate having an average number of added moles of ethylene oxide of 10 or less. [3] The liquid oral composition according to [2], wherein the component (A) is selected from glyceryl oleate, glyceryl linoleate, sorbitan oleate, sucrose oleate and sucrose erucate. [4] The liquid oral composition according to any one of [1] to [3], wherein the component (D) is at least one selected from sorbitol, xylitol, erythritol, lactitol, mannitol, maltitol, isomalt and glycerin. [5] The liquid oral composition according to any one of [1] to [4], containing 0.01 to 0.5% by mass of the component (A), 1 to 30% by mass of the component (B) and 1 to 30% by mass of the component (D). [6] The liquid oral composition according to any one of [1] to [5], wherein ((B)+(D)) / (C) is 5 to 200 as a mass ratio. [7] The liquid oral composition according to any one of [1] to [6], wherein (D) / (C) is 1 to 100 as a mass ratio. [8] The liquid oral composition according to any one of [1] to [7], which is a mouthwash.

Advantages of the Invention

[0010] According to the present invention, it is possible to provide a liquid oral composition having an excellent selective antibacterial effect against pathogenic bacteria in the oral cavity, particularly periodontal pathogenic bacteria, and having appearance stability. The liquid oral composition of the present invention is effective for preventing or suppressing periodontal disease.

BEST MODE FOR CARRYING OUT THE INVENTION

[0011] The present invention will be described in more detail below. The liquid oral composition of the present invention contains (A) an ester compound of a specific unsaturated fatty acid and a polyhydric alcohol described below, (B) ethanol, (C) a specific polyoxyethylene hydrogenated castor oil, and (D) a sugar alcohol and / or glycerin.

[0012] Component (A) is an ester compound of an unsaturated fatty acid having 18 to 22 carbon atoms and a polyhydric alcohol. This ester compound selectively antibacterializes pathogenic bacteria in the oral cavity, and further has an action of selectively promoting the growth of oral resident bacteria and improving the flora. In particular, it has a high selective antibacterial effect (hereinafter, may also be referred to as a selective antibacterial effect) against pathogenic bacteria in the oral cavity, especially periodontal pathogenic bacteria. This ester compound is formulated as an active ingredient for selective antibacterial of pathogenic bacteria. In the present invention, as shown in the examples described below, in a system assuming the bacterial flora in the oral cavity, the Tr of oral resident bacteria is preferably 1.0 or more, more preferably 1.1 or more, still more preferably 1.5 or more, and the Tr against pathogenic bacteria is preferably less than 0.5, more preferably less than 0.2, still more preferably less than 0.05. When these are satisfied, it has a selective antibacterial effect against pathogenic bacteria.

[0013] In the above ester compound, the unsaturated fatty acid is an unsaturated fatty acid having 18 to 22 carbon atoms, and examples thereof include oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), and erucic acid (C22:1). In particular, oleic acid, linoleic acid, and erucic acid are preferred. The numerical values in parentheses represent the number of carbon atoms: the number of unsaturated bonds. When the number of carbon atoms of the unsaturated fatty acid is less than 18, or in the case of a saturated fatty acid, the selective antibacterial effect is inferior. When the number of carbon atoms of the unsaturated fatty acid exceeds 22, the appearance stability is not improved and is inferior. Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, glycerin, sorbitan, sorbitol, sucrose, polyethylene glycol, polyglycerin, and polyoxyethylene (polyethylene oxide). Among them, ethylene glycol, propylene glycol, glycerin, sorbitan, sucrose, and polyethylene glycol are particularly preferable, and glycerin, sorbitan, and sucrose are more preferable. In the case of polymers such as polyglycerin, the degree of polymerization is not particularly defined, but preferably 10 or less, more preferably 6 or less, based on the degree of polymerization of glycerin. A lower degree of polymerization provides a more excellent selective antibacterial effect. Note that non-polymerized glycerin is more preferable. In the case of polyethylene glycol and polyoxyethylene, the average number of added moles of ethylene oxide (E.O.) is not particularly defined, but preferably 10 or less, more preferably 6 or less, respectively. A lower E.O. provides a more excellent selective antibacterial effect.

[0014] Specific examples of the ester compound of the unsaturated fatty acid and the polyhydric alcohol include glyceryl oleate, glyceryl linoleate, glyceryl linolenate, glyceryl erucate, polyglyceryl oleate, polyglyceryl linoleate, polyglyceryl linolenate, polyglyceryl erucate, sorbitan oleate, sorbitan linoleate, sorbitan linolenate, sorbitan erucate, sucrose oleate, sucrose linoleate, sucrose linolenate, sucrose erucate, polyethylene glycol oleate, polyethylene glycol linoleate, polyethylene glycol linolenate, polyethylene glycol erucate, polyoxyethylene sorbitan oleate, polyoxyethylene sorbitan linoleate, polyoxyethylene sorbitan linolenate, polyoxyethylene sorbitan erucate, polyoxyethylene glyceryl oleate, polyoxyethylene glyceryl linoleate, polyoxyethylene glyceryl linolenate, polyoxyethylene glyceryl erucate, and the like. Among them, oleate, linoleate, and erucate are preferred. Specifically, glyceryl oleate, glyceryl linoleate, polyglyceryl oleate (especially with E.O. 10 or less), sorbitan oleate, sucrose oleate, sucrose erucate, polyethylene glycol oleate (especially with E.O. 10 or less), polyoxyethylene sorbitan oleate (especially with E.O. 10 or less), and polyoxyethylene glyceryl oleate (especially with E.O. 10 or less) are preferred. More preferably, glyceryl oleate, glyceryl linoleate, polyglyceryl oleate (especially with E.O. 10 or less), sorbitan oleate, sucrose oleate, sucrose erucate, polyethylene glycol oleate (especially with E.O. 10 or less). Even more preferably, glyceryl oleate, glyceryl linoleate, sorbitan oleate, sucrose oleate, and sucrose erucate. The above ester compounds can be used alone or in combination of two or more. Also, commercially available products can be used.

[0015] Incidentally, the component (A) can also be formulated as an ester compound of a fatty acid containing the above unsaturated fatty acid and a polyhydric alcohol.

[0016] As described above, the component (A) which is an active ingredient has the effect of selectively antibacterial against pathogenic bacteria in the oral cavity, and further selectively promoting the growth of indigenous bacteria in the oral cavity and improving the flora, thereby increasing the proportion of indigenous bacteria in the oral cavity and acting as an improvement of the oral bacterial flora that improves the bacterial composition ratio of the oral bacterial flora. Examples of oral resident bacteria include bacteria of the genus Streptococcus, bacteria of the genus Neisseria, bacteria of the genus Rothia, and bacteria of the genus Actinomyces, with bacteria of the genus Streptococcus being preferred. Specifically, Streptococcus gordonii, Streptococcus oralis, Streptococcus mitis, Streptococcus salivarius, Streptococcus peroris, Streptococcus infantis, Streptococcus sanguinis, Actinomyces viscosus, Actinomyces naeslundii, Neisseria subflaba, Neisseria sicca, Rothia dentocariosa, Rothia mucilaginosa, etc. are included. Among them, preferred bacteria are Neisseria subflaba and Neisseria sicca, which tend to grow abundantly in the oral cavity where periodontal disease has not developed, and bacteria of the genus Streptococcus, Rothia dentocariosa, and Rothia mucilaginosa, which have an antibacterial effect against periodontal pathogenic bacteria. Component (A) has an excellent growth promoting effect on one or more oral resident bacteria selected from these.

[0017] Examples of pathogenic bacteria include those that cause periodontal disease and halitosis, such as bacteria of the genus Porphyromonas, Prevotella, Fusobacterium, Treponema, Tannerella, Campylobacter, and Eubacterium. Among them, bacteria of the genus Porphyromonas, Prevotella, and Fusobacterium, especially bacteria of the genus Porphyromonas, are particularly notable. Specifically, examples include Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, etc. Among them, the effective bacterium is Porphyromonas gingivalis, a periodontal pathogen. The component (A) has an excellent selective antibacterial action against one or more pathogenic bacteria selected from these.

[0018] (A) The compounding amount of the component is preferably 0.01 to 0.5% (mass%, the same hereinafter) of the whole composition, more preferably 0.015 to 0.3%, and still more preferably 0.02 to 0.1%. When the compounding amount is 0.01% or more, a sufficient selective antibacterial effect can be obtained, and when it is 0.5% or less, sufficient appearance stability can be ensured.

[0019] (B) Ethanol has the effect of giving a refreshing feeling after use and also contributes to maintaining the appearance stability after storage at high temperature. (B) The compounding amount of the component is preferably 1 to 30% of the whole composition, more preferably 2 to 28%, and still more preferably 3 to 25%. When the compounding amount is 1% or more, a sufficient refreshing feeling after use can be obtained and sufficient appearance stability can be obtained. When it is 30% or less, sufficient appearance stability can be maintained.

[0020] (C) The component is polyoxyethylene hydrogenated castor oil with an average addition mole number of ethylene oxide of 40 to 100 moles, preferably 60 moles. This solubilizes the component (A), suppresses the generation of cloudiness even after storage at high temperature, and has the effect of improving appearance stability. It is also involved in maintaining the selective antibacterial effect by the component (A). If the average number of moles of ethylene oxide added is less than 40 or exceeds 100, the appearance stability deteriorates, and the selective antibacterial effect may be impaired. (C) component can specifically use commercially available products such as NIKKOL HCO-40, 60, 80, 100, etc. manufactured by Nikko Chemicals Co., Ltd.

[0021] (C) component's blending amount is 0.1 - 1.8% of the whole composition, preferably 0.15 - 1.6%, more preferably 0.2 - 1.5%. When the blending amount is less than 0.1%, the appearance stability is poor, and when it exceeds 1.8%, the selective antibacterial effect cannot be obtained sufficiently.

[0022] (D) component is sugar alcohol and / or glycerin, which play a role in maintaining the selective antibacterial effect and are also involved in improving the appearance stability. Sugar alcohols include, for example, sorbitol, xylitol, erythritol, lactitol, mannitol, maltitol, isomalt, etc. These can be used alone or in combination of two or more.

[0023] (D) component's blending amount is preferably 1 - 30% of the whole composition, more preferably 1.5 - 28%, and even more preferably 3 - 25%. When the blending amount is within the above range, sufficient selective antibacterial effect and appearance stability can be achieved simultaneously. When the blending amount is 1% or more, the selective antibacterial effect is maintained sufficiently, and when it is 30% or less, the appearance stability is obtained sufficiently.

[0024] ((B)+(D)) / (C) showing the quantitative ratio of the total amount of (B) and (D) components to the amount of (C) component is preferably 5 - 200 as a mass ratio, more preferably 6 - 180, and even more preferably 8 - 150. When within the above range, the selective antibacterial effect and appearance stability are more excellent. When the mass ratio of ((B)+(D)) / (C) is less than 5, the selective antibacterial effect may be impaired, and when it exceeds 200, the appearance stability may be impaired.

[0025] Also, (D) / (C) indicating the quantitative ratio of component (C) and component (D) is preferably 1 to 100, more preferably 1.5 to 95, still more preferably 2 to 90 as a mass ratio. When within the above range, the selective antibacterial effect and appearance stability are further excellent. If the mass ratio of (D) / (C) is less than 1, the selective antibacterial effect may be impaired, and if it exceeds 100, the appearance stability may be impaired. It is particularly preferable that both the mass ratio of ((B)+(D)) / (C) and the mass ratio of (D) / (C) are within the above range.

[0026] The liquid oral composition of the present invention can be prepared and applied particularly as a mouthwash in dosage forms such as a mouthwash, an oral coolant, a concentrated type mouthwash, etc. In this case, in addition to the above components, appropriate known components according to the dosage form can be blended as needed. For example, a humectant other than component (D), a thickener, a surfactant other than component (C), a pH adjuster, a preservative, a sweetener, a fragrance, a coloring agent, an active ingredient other than component (A), a solvent, etc. can be blended. Note that the blending amounts shown below are the blending amounts with respect to the entire composition.

[0027] Optional humectant: Examples include propylene glycol, ethylene glycol, and polyethylene glycol. The blending amount of the above optional humectant is preferably 0 to 30%, and when blending, 1 to 30% is preferable.

[0028] Thickener: Examples include xanthan gum, carrageenan, carboxymethyl cellulose, hydroxyethyl cellulose, sodium alginate, polyvinyl alcohol, etc. The blending amount of the thickener is usually 0 to 5%, and when blending, 0.1 to 5% is preferable.

[0029] Optional surfactant: An anionic surfactant, an amphoteric surfactant, and a nonionic surfactant other than component (C) can be blended, and for example, those shown below can be used. Anionic surfactant Examples include alkyl sulfate salts such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium α-sulfo fatty acid alkyl ester, and alkyl phosphate salts. Amphoteric surfactants Examples include betaine-type such as alkyl dimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine, and imidazoline-type such as N-fatty acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salt. Any nonionic surfactant Examples include sugar alcohol fatty acid esters such as sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and sucrose fatty acid esters, polyhydric alcohol fatty acid esters such as glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, and polyethylene glycol fatty acid esters, ether-type such as polyoxyethylene polyoxypropylene copolymers, polyoxyethylene alkyl phenyl ethers, and polyoxyethylene alkyl ethers, and fatty acid alkanolamides such as lauric acid diethanolamide. When blending any of the above surfactants, the blending amount is preferably 0.01 to 1%, and may be less than 0.01% or may be 0% without blending.

[0030] pH adjuster: Examples include citric acid, phosphoric acid, phthalic acid, acetic acid, fumaric acid, carbonic acid, and salts thereof such as potassium salts, sodium salts, and ammonium salts, ribonucleic acid or its salts. Preservative: Examples include paraoxybenzoic acid esters such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben, benzoic acid or its salts such as sodium benzoate, alkyldiaminoethyl glycine hydrochloride, and potassium sorbate. Sweetener: Examples include sodium saccharin, stevioside, sucralose, reduced palatinose, erythritol, etc. Colorant: Examples of highly safe water-soluble dyes include Food Green No. 3, Food Yellow No. 4, Food Red No. 105, and Food Blue No. 1.

[0031] Fragrance: Natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, and para-cresol methyl ether; fragrance components contained in the above natural essential oils such as l-carvone, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthol, menthone, menthyl acetate, citral, camphor, borneol, pinene, and spirantol; and ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, vanilla, ethylvanillin, furaneol, maltol, ethyl maltol, gamma / delta-decalactone, gamma / delta-undecalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate, etc. Further, compounded flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, and yogurt (preferably not containing ethanol), which are combinations of several fragrance components and natural essential oils, may be mentioned. The above fragrance materials are preferably used in an amount of 0.000001 to 1% in the composition, and the fragrance for flavoring using the above fragrance materials is preferably used in an amount of 0.1 to 2%, particularly 0.2 to 2% in the composition. The above fragrance materials can be blended within a range where the appearance stability is not reduced. When ethanol is contained in the fragrance, it is preferable that the total ethanol amount including the ethanol amount is within the range of the blending amount of the component (B) above.

[0032] Optional active ingredient: Plant extracts such as thyme, saffron, ginger, witch hazel, sodium fluoride, sodium monofluorophosphate, tin fluoride and other fluorine compounds, isopropyl methylphenol, triclosan, sodium lauroyl sarcosinate, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride and other bactericides, tranexamic acid, epsilon - aminocaproic acid, beta - glycyrrhetinic acid, dipotassium glycyrrhizinate and other anti - inflammatory agents, dextranase, amylase, protease, mutanase, lysozyme, lysing enzyme, lytech enzyme and other enzymes, aluminum chlorohydroxyalanthoin, allantoin, azulene, lysozyme chloride, vitamin C such as ascorbic acid or its derivatives, vitamin E such as tocopherol and its derivatives, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acids, cholesterol, chlorophyll, sodium copper chlorophyllin, copper gluconate, caropeptide, sodium polyphosphate, water - soluble inorganic phosphate compounds, polyethylene glycol, polyvinylpyrrolidone, tartar - preventing agent, plaque - preventing agent, potassium nitrate, aluminum lactate, polyoxyethylene lauryl ether. The compounding amount of any of the above active ingredients can be an effective amount within a range that does not interfere with the effects of the present invention.

[0033] Solvent: Purified water, (B) lower monohydric alcohols having 2 - 4 carbon atoms other than ethanol can be mentioned.

[0034] Containers for accommodating the liquid oral composition can be PET (polyethylene terephthalate), glass, polypropylene, polyethylene, but from the viewpoint of suppressing the adsorption of fragrance, the use of PET and glass is preferred.

Examples

[0035] Hereinafter, examples, comparative examples, and formulation examples will be shown to specifically explain the present invention, but the present invention is not limited to the following examples. In the following examples, % indicates mass % unless otherwise specified.

[0036] [Examples, Comparative Examples] Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 to 4 were prepared by a conventional method and evaluated by the following method. The results are also shown in Tables 1 to 4.

[0037] (1) Method for evaluating the selective antibacterial effect against periodontal pathogenic bacteria Using the cryopreserved strains of the bacteria (oral resident bacteria, periodontal pathogenic bacteria) described below, each bacterium was cultured on a blood agar plate *1 at 37°C for 2 days. The grown colonies were inoculated into 4 mL of tryptic soy medium (TS medium, manufactured by Becton and Dickinson), and anaerobically cultured at 37°C for 1 day (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) to prepare a bacterial culture solution for each bacterium. 100 μL of a 2-fold concentrated TS medium containing 2% of the bacterial culture solution was added to a 96-well microplate (manufactured by Sumitomo Bakelite Co., Ltd.). Further, 100 μL of the evaluation sample was added so that the final concentration was 0.01% (the control was without addition, and instead 100 μL of purified water was added), and anaerobic (80 vol% nitrogen, 10 vol% carbon dioxide, 10 vol% hydrogen) culture was carried out at 37°C for 18 hours. For each bacterium, the amount of grown bacteria was measured by turbidity at a wavelength of 550 nm. Before turbidity measurement, the plate was shaken to stir the bacterial culture solution. The growth degree of the bacteria was determined by obtaining the relative value Tr (= Ts / Tc) of the turbidity increase amount (Ts) of the bacterial culture solution with the addition of the evaluation sample to the turbidity increase amount (Tc) of the control bacterial culture solution, and this Tr value was used as an index. When the Tr value is greater than 1.0, the growth is promoted, and when it is less than 1.0, the growth is suppressed (antibacterial effect). Based on the following evaluation criteria, the influence on the growth of bacteria ((i) influence on the growth of oral resident bacteria (growth promotion effect), (ii) influence on the growth of periodontal pathogenic bacteria (antibacterial effect)) was evaluated from the above Tr values. (i) and (ii) were judged to have a selective antibacterial effect (flora improvement effect) against periodontal pathogenic bacteria when the evaluation results of both were A to C. The above effect is preferably when either one of the evaluation results of (i) and (ii) is A or B (patterns of AA, AB, BB, AC, BC), more preferably when both evaluation results are A or B (patterns of AA, AB, BB), and even more preferably when both evaluation results are A. Evaluation criteria for the effect on bacterial growth (i) Effect on the growth of oral resident bacteria (growth promotion effect) Tr (= Ts / Tc) A: 1.5 or more B: 1.1 or more and less than 1.5 C: More than 1.0 and less than 1.1 D: 1.0 or less (ii) Effect on the growth of periodontal pathogenic bacteria (antibacterial effect) Tr (= Ts / Tc) A: Less than 0.05 B: 0.05 or more and less than 0.2 C: 0.2 or more and less than 0.5 D: 0.5 or more and less than 1.0

[0038] *1: Composition of blood agar medium: Todd-Hewitt broth (manufactured by Becton and Dickinson): 30 g / L Agar (manufactured by Becton and Dickinson): 15 g / L Hemin (manufactured by Sigma-Aldrich): 5 mg / L Vitamin K (manufactured by Fujifilm Wako Pure Chemical Corporation): 1 mg / L Distilled water: The balance (Made up to 1 L in total and autoclaved at 121 °C for 20 minutes.) Sheep defibrinated blood (manufactured by Nippon Bio-Test Laboratories): 100 mL The bacteria used for the evaluation were the following bacterial species purchased from the American Type Culture Collection (hereinafter abbreviated as ATCC). Oral resident bacteria: Streptococcus gordonii ATCC10558 Periodontal pathogen: Porphyromonas gingivalis ATCC33277

[0039] (2) Method for evaluating appearance stability The liquid oral composition immediately after preparation was filled with 450 mL into a transparent PET container (manufactured by Yoshino Kogyosho Co., Ltd.) with a filling volume of 500 mL, stored in a thermostat at 50 °C (manufactured by Sanyo Electric Co., Ltd., MPR-311) for 1 month, and then returned to room temperature. Regarding the clarity of the appearance, purified water was filled into the same transparent PET container as above and stored in the same manner. The visual judgment was made based on the evaluation criteria shown below and compared with the control product. The liquid oral composition of the example immediately after preparation had a clear appearance. It was judged that the products rated as ◎ or ○ had the turbidity suppressed even after high-temperature storage, and the appearance stability passed. Evaluation criteria for appearance stability ◎: No turbidity is observed and it is clear. ○: Slight turbidity is observed, but it is at a level where it cannot be distinguished without the control product, and the clarity is not a problem. △: Slight turbidity is observed to the extent that it can be distinguished even without the control product. ×: Turbidity is clearly observed even without comparison with the control product, and the turbidity is so severe that it is difficult to see through the PET container.

[0040] Details of the raw materials used are shown below. (A) component Glyceryl oleate: Glyceryl monooleate (manufactured by Fujifilm Wako Pure Chemical Corporation) Glyceryl linoleate: Glyceryl monolinoleate (manufactured by Fujifilm Wako Pure Chemical Corporation) Sorbitan oleate: span80 (manufactured by Fujifilm Wako Pure Chemical Corporation) Sucrose oleate: Ryoto Sugar Ester O-1570 (manufactured by Mitsubishi Chemical Foods Co., Ltd.) (B) component Ethanol: Traceable 95, primary grade (manufactured by Nippon Alcohol Sales Co., Ltd.) The numerical values indicating the compounding amounts in the table are the total amount of ethanol contained in the composition. Component (C) Polyoxyethylene hydrogenated castor oil (40): NIKKOL HCO-40 (manufactured by Nikko Chemicals Co., Ltd.) Polyoxyethylene hydrogenated castor oil (60): NIKKOL HCO-60 (manufactured by Nikko Chemicals Co., Ltd.) Polyoxyethylene hydrogenated castor oil (100): NIKKOL HCO-100 (manufactured by Nikko Chemicals Co., Ltd.) Polyoxyethylene hydrogenated castor oil (20) (comparative component): NIKKOL HCO-20 (manufactured by Nikko Chemicals Co., Ltd.) Note that the numerical value in () of the polyoxyethylene hydrogenated castor oil is the average number of moles of ethylene oxide added. Component (D) Sorbitol: Sorbit 70 (manufactured by Mitsubishi Corporation Life Sciences Ltd.) Glycerin: Natural glycerin (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.) Xylitol: XYLISORB700 (manufactured by Nagase Sangyo Co., Ltd.) 1,3-Butylene glycol (comparative component): High Sugar Cain BG (manufactured by Kao Alcohol Industries Co., Ltd.) The numerical values indicating the compounding amounts in the table are the amounts converted to pure components for components without the description of the pure component content (%), and the same applies to the formulation examples described later.

[0041]

Table 1

[0042]

Table 2

[0043]

Table 3

[0044]

Table 4

[0045] Next, formulation examples will be shown. The raw materials used are the same as above. When the mouthwash of the formulation example was evaluated as described above, it was excellent in the selective antibacterial effect against periodontal pathogenic bacteria and had appearance stability.

[0046] [Formulation Example 1] Mouthwash (A) Glyceryl monooleate 0.05 (B) Ethanol 8 (C) Polyoxyethylene hydrogenated castor oil (60) 0.5 (D) Sorbitol 7 Propylene glycol 4 Citric acid 0.03 Sodium citrate 0.25 Fragrance 0.2 Purified water remainder Total 100% Mass ratio of ((B)+(D)) / (C): 30 Mass ratio of (D) / (C): 14

[0047] [Formulation Example 2] Mouthwash (A) Glyceryl monooleate 0.05 (B) Ethanol 8 (C) Polyoxyethylene hydrogenated castor oil (60) 0.5 (D) Glycerin 7 Propylene glycol 2 Citric acid 0.01 Sodium citrate 0.2 Fragrance 0.4 Purified water remainder Total 100% Mass ratio of ((B)+(D)) / (C): 30 Mass ratio of (D) / (C): 14

[0048] [Formulation Example 3] Mouthwash (A) Glyceryl monooleate 0.05 (B) Ethanol 8 (C) Polyoxyethylene hydrogenated castor oil (60) 0.5 (D) Sorbitol 7 Propylene glycol 4 Sodium lauroyl sarcosinate 0.01 Citric acid 0.03 Sodium citrate 0.25 Sodium saccharin 0.001 Fragrance 0.3 Purified water remainder Total 100% Mass ratio of ((B)+(D)) / (C): 30 Mass ratio of (D) / (C): 14

Claims

1. One or more selected from (A) glyceryl oleate, glyceryl linoleate, sorbitan oleate, sucrose oleate, and sucrose erucate, (B) ethanol, (C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and (D) one or more selected from sugar alcohols and glycerin are contained, A liquid oral composition in which the content of component (A) is 0.01 to 0.5% by mass, the content of component (B) is 1 to 30% by mass, the content of component (C) is 0.1 to 1.8% by mass, and the content of component (D) is 1 to 30% by mass.

2. The liquid oral composition according to claim 1, wherein component (D) is one or more selected from sorbitol, xylitol, erythritol, lactitol, mannitol, maltitol, isomalt, and glycerin.

3. The liquid oral composition according to claim 1 or 2, wherein ((B) + (D)) / (C) is 5 to 200 as a mass ratio.

4. The liquid oral composition according to any one of claims 1 to 3, wherein (D) / (C) is 1 to 100 as a mass ratio.

5. The liquid oral composition according to any one of claims 1 to 4, which is a mouthwash.

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