Skin cleansing spray agent

Abstract

To provide a skin cleanser composition that is used in an unconventional method.SOLUTION: A spray agent for skin cleansing, which contains (A) a surfactant of natural origin and (B) an amphiphilic ester with the content of (A) of 0.025-2 wt.%, while being contained in a spray container, is capable of exhibiting excellent cleansing power, while being reduced in the skin irritancy of a skin cleanser composition, and is able to provide a novel use that is different from conventional uses in which the skin cleanser composition is foamed before application to the skin, said novel use being direct spraying of the skin cleanser composition onto the skin.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a skin cleansing spray agent that is directly sprayed onto the skin for use.

Background Art

[0002] As products for the purpose of cleansing the skin and keeping the skin clean, various skin cleansing compositions such as facial cleansers, body soaps, and shampoos are provided. In the mechanism by which a skin cleansing composition cleanses the skin, a surfactant adsorbs to dirt and reduces the surface tension between the dirt and water. Together with the mechanical force due to friction, the dirt is lifted into the water. In order for such a cleaning mechanism to act effectively, it is necessary to blend the surfactant at a concentration above the critical micelle concentration.

[0003] On the other hand, there is also a current situation where the cleaning power of the surfactant is too strong, causing skin irritation, and as a result, skin problems such as dry skin are caused. For this reason, various formulations have been proposed to devise the combination and blending amount of cleaning components for the purpose of making the action on the skin mild. Among them, since it is recognized that the foam formed during cleaning reduces the friction generated by direct contact between the skin and the fingers, formulations that improve the foam quality such as the foaming power and foam retention power are generally considered to be excellent formulations for making the action on the skin mild.

[0004] For this reason, in recent years, various pump-former type skin cleansers have been proposed, and attention has been paid not only to the ease of obtaining high-quality foam easily but also to the gentleness to the skin. Specifically, Patent Document 1 discloses a liquid skin cleanser product comprising a former container and a liquid skin cleanser composition filled in this former container, wherein the liquid skin cleanser composition contains (A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group with 7 to 21 carbon atoms, (B) a copolymer of a specific dimethyldiallylammonium chloride and acrylic acid and / or acrylamide, and (C) a sugar alcohol, and a liquid skin cleanser product is disclosed in which the mass ratio (A) / (B) of the content of component (A) to the content of component (B) is 20 to 250. Further, Patent Document 2 discloses a skin cleanser composition characterized in that a cleanser containing (a) 2 to 9% by mass of a fatty acid salt, (b) 0.5 to 4% by mass of lauryldimethylaminoacetic acid betaine, (c) one or more divalent alcohols in an amount of 1 to 10% by mass, and the sum (a)+(b) of the blending amounts (mass%) of component (a) and component (b) is 3 to 10% by mass, and the blending ratio (b) / (a) is 0.1 to 0.5 is filled in a former container. Furthermore, Patent Document 3 discloses a cleansing composition discharged from a former container containing (a) lauryldimethylaminoacetic acid betaine and (b) 4 to 15% by mass of a higher fatty acid soap formed from a fatty acid having 5 to 25 carbon atoms and having a specific composition.

[0005] On the other hand, in consideration of the environmental load, a cleansing composition using a biodegradable natural surfactant is also known. For example, Patent Document 4 discloses a cleansing composition comprising 11 to 45 parts by weight of a natural surfactant, 25 to 35 parts by weight of mirabilite, 10 to 40 parts by weight of a hard water softener, 0.1 to 5 parts by weight of a chelating agent, and the balance of additional cleansing raw materials totaling 100 parts by weight.

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

[0007] In a pump-former type skin cleansing composition, the amount of surfactant blended is relatively small, and in this regard, it is considered that the irritation to the skin is likely to be reduced compared to solid or semi-solid skin cleansing compositions. On the other hand, since it is a prerequisite for a pump-former type skin cleansing composition to be discharged in a foamy state, it is inevitable in its configuration to blend a minimum amount of surfactant necessary to exhibit foaming power.

[0008] In addition, various skin cleansing products have been created for the purpose of removing body fluids such as sebum and sweat and dirt, excluding skin cleansing products for makeup removal (cleansing). However, without exception, all skin cleansing products, including pump-former type skin cleansing products and skin cleansing products containing natural surfactants, are premised on foaming before applying to the skin. Also, it is common knowledge that foaming well before washing is preferable in terms of reducing friction on the skin. Although bubbles can reduce physical friction by intervening between the skin and the hand, since the bubbles themselves are rubbed against the skin, they themselves cause physical friction and inevitably cause irritation to the skin. Thus, with the same usage method as before, there is a limit to reducing the burden on the skin of skin cleansing products.

[0009] Therefore, an object of the present invention is to provide a skin cleansing composition used in a method different from the conventional one. [Means for Solving the Problems]

[0010] In order to further reduce the irritation to the skin, the inventor came up with an innovative idea of directly spraying and applying the skin cleansing composition to the skin without prior foaming when applying it to the skin. Also, in order to further reduce the irritation to the skin, a natural surfactant was blended, and the blending amount was significantly reduced compared to the blending amount contained in the conventional skin cleansing composition. In such a skin cleansing composition containing only a significantly small amount of surfactant, cleansing power cannot be obtained in exchange for reduced skin irritation. However, it has been found that by coexisting an amphiphilic ester, effective cleansing power can be obtained without prior foaming. The present invention has been completed by further studies based on this finding.

[0011] That is, the present invention provides an invention in the following aspects. Item 1. A skin cleansing spray agent contained in a spray container, which contains (A) a natural surfactant and (B) an amphiphilic ester, wherein the content of (A) is 0.025 to 2% by weight. Item 2. The skin cleansing spray agent according to Item 1, wherein the spray container is a pump-type spray container. Item 3. The skin cleansing spray agent according to Item 1, wherein the spray container is an aerosol-type spray container. Item 4. The skin cleansing spray agent according to any one of Items 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponins, and lipopeptides. Item 5. The skin cleansing spray agent according to Item 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin, and hydrogenated lecithin. Item 6. The skin cleansing spray agent according to Item 4, wherein the lipopeptide is selected from the group consisting of surfactin and its salts. Item 7. The skin cleansing spray agent according to any one of Items 1 to 6, wherein the component (B) is selected from the group consisting of dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10. Item 8. The skin cleansing spray agent according to Item 7, wherein the dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.

Advantages of the Invention

[0012] According to the present invention, since the skin irritation of the skin cleansing composition can be reduced while exhibiting excellent detergency, unlike the conventional use of foaming in advance when applying to the skin, a new use of directly spraying the skin cleansing composition onto the skin for application can be provided. Since it can be cleaned without foaming in advance, the blending amount of the surfactant in the liquid composition for skin cleansing can be significantly reduced compared to the blending amount contained in the conventional liquid composition for skin cleansing, and thereby it is also possible to further reduce skin irritation.

Embodiments for Carrying Out the Invention

[0013] The skin cleansing spray agent of the present invention contains (A) a natural surfactant (hereinafter sometimes referred to as component (A)) in a predetermined amount and (B) an amphiphilic ester (hereinafter sometimes referred to as component (B)), and is characterized by being housed in a spray container. Hereinafter, the skin cleansing spray agent of the present invention will be described in detail.

[0014] (A) Naturally-derived surfactant The skin cleansing spray agent of the present invention contains a natural surfactant as component (A). A natural surfactant is a substance of biological origin having a surfactant action.

[0015] The natural surfactant used in the present invention is not particularly limited, and examples include natural products extracted and purified from animals, plants or microorganisms; those obtained by microbiologically culturing and synthesizing these natural products, those synthesized by genetic engineering, and those chemically synthesized; those subjected to treatments such as hydrogenation treatment, hydroxylation treatment, hydrolysis treatment, etc.

[0016] Examples of the naturally-derived surfactants used in the present invention include phospholipids, saponins, lipopeptides, cholesterol, bile acids, and the like. These naturally-derived surfactants may be used alone or in combination of two or more. Among these naturally-derived surfactants, preferably, phospholipids, saponins, and lipopeptides are mentioned.

[0017] Examples of phospholipids include glycerophospholipids, sphingophospholipids, and the like. Glycerophospholipids are substances having a glycerophosphoric acid skeleton and having a fatty acid ester, a long-chain alkyl ether, a vinyl ether, or the like as a lipophilic group. Specific examples of glycerophospholipids include phosphatidylcholine (lecithin), phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylinositol polyphosphate, diphosphatidylglycerol (cardiolipin), phosphatidic acid, and hydrogenated products, hydroxylated products, and hydrolyzed products thereof. Sphingophospholipids are phosphoric acid or phosphonic acid derivatives of long-chain bases such as sphingosine and phytosphingosine or long-chain fatty acids. Specific examples of sphingophospholipids include ceramide 1-phosphate derivatives (such as sphingomyelin) and ceramide 1-phosphonic acid derivatives (such as ceramide aminoethylphosphonic acid). These phospholipids may be used alone or in combination of two or more.

[0018] Among these phospholipids, preferably, glycerophospholipids are mentioned, more preferably, lecithin (soybean lecithin, egg yolk lecithin), hydrogenated lecithin, hydroxylated lecithin, and lysophosphatidylcholine are mentioned, and still more preferably, lecithin (soybean lecithin, egg yolk lecithin, etc.), hydrogenated lecithin, and lysophosphatidylcholine are mentioned. Further, from the viewpoint of obtaining better detergency, preferably, lecithin (soybean lecithin, egg yolk lecithin, etc.) and lysophosphatidylcholine are mentioned, and from the viewpoint of further suppressing the tight feeling due to skin irritation and lack of moisturization, preferably, hydrogenated lecithin is mentioned.

[0019] Saponin is a glycoside composed of sapogenin and sugar, and specifically includes triterpene glycosides and steroid glycosides. Specific examples of saponin include quillaia saponin, soybean saponin, yucca saponin, endive saponin, beet saponin, adzuki bean saponin, carrot saponin, tea seed saponin, loofah saponin, tubocapsicum saponin, etc. These saponins may be used alone or in combination of two or more.

[0020] Lipopeptide is a lipidated peptide, and specifically includes surfactin, arthrofactin, iturin, and salts thereof. These lipopeptides may be used alone or in combination of two or more.

[0021] Among these lipopeptides, preferably surfactin and its salts are included, and more preferably salts of surfactin are included. The salt of surfactin is a compound represented by the following formula (I).

[0022]

Chemical formula

[0023] In formula (I), X represents an amino acid residue selected from leucine, isoleucine, and valine, and R represents a C 9-18 alkyl group, and M + represents an alkali metal ion or a quaternary ammonium ion. The alkali metal ion is not particularly limited, and examples thereof include lithium ion, sodium ion, potassium ion, etc., and preferably sodium ion. Examples of the substituent of the quaternary ammonium ion include alkyl groups such as methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, tert-butyl group; aralkyl groups such as benzyl group, methylbenzyl group, phenylethyl group; and organic groups such as aryl groups such as phenyl group, toluyl group, xylyl group. These surfactins or their salts may be used alone or in combination of two or more.

[0024] The content of component (A) in the skin cleansing spray agent of the present invention is 0.025 to 2% by weight. Since the amount of the surfactant is small in this way, skin irritation can be reduced at each stage. In the present invention, by coexisting with component (B), excellent detergency can be exhibited, so that even a small amount of surfactant that cannot originally exhibit effective detergency can effectively exhibit detergency.

[0025] Preferred contents of component (A) include, for example, 0.5 to 2% by weight, more preferably 1 to 2% by weight, from the viewpoint of obtaining even more excellent detergency, and 0.025 to 1.5% by weight, more preferably 0.025 to 1% by weight, from the viewpoint of further suppressing the tight feeling due to insufficient moisturization. Further, when component (A) is lecithin or lysophosphatidylcholine, 0.5 to 2% by weight is mentioned from the viewpoint of obtaining even more excellent detergency, 0.025 to 1% by weight is mentioned from the viewpoint of further suppressing the tight feeling due to insufficient moisturization, and 0.025 to 1.5% by weight is mentioned from the viewpoint of further suppressing skin irritation. When component (A) is saponin, 1 to 2% by weight is mentioned from the viewpoint of obtaining even more excellent detergency.

[0026] (B) Amphiphilic ester The skin cleansing spray agent of the present invention contains an amphiphilic ester as component (B). Component (B) does not show a cleaning action alone, but by coexisting with 0.025 to 2% by weight of component (A), the detergency of the skin cleansing spray agent can be improved while maintaining low irritation.

[0027] In the present invention, the amphiphilic ester is dissolved in ion-exchanged water adjusted to a conductivity of 70 to 110 μs / m at room temperature in an amount of 2% by mass or more by the method defined in the general test method of the Japanese Pharmacopoeia, and is also dissolved in isononanoic acid isotridecyl (manufactured by Nisshin Oillio Group, Saracos 913), which is an oil agent, in an amount of 10% by mass or more at room temperature (25°C). Ester-based surfactants are excluded.

[0028] The amphiphilic ester is not particularly limited, but from the viewpoints of reducing skin irritation and obtaining better detergency, it is preferably selected from the group consisting of dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10. As the amphiphilic ester, any one of dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 may be used alone, or two or more thereof may be used in combination. Among these amphiphilic esters, from the viewpoint of further suppressing the tight feeling due to insufficient moisturization, dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester is more preferable.

[0029] The dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester include, for example, oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid, and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include, for example, polyoxyethylene monoalkyl ether, and more specifically, for example, diethylene glycol monoethyl ether, triethylene glycol monoethyl ether, and the like.

[0030] Among these dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters, from the viewpoint of better reducing skin irritation and detergency, preferably, a diester compound of cyclohexane-1,4-dicarboxylic acid and diethylene glycol monoethyl ether, specifically, a compound called bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate, which is represented by the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13th Edition, Volume 1, CTFA, 2010, p. 331): BIS-ETHOXYDIGLYCOL CYCLOHEXANE 1,4-DICARBOXYLATE, and a diester compound of succinic acid and diethylene glycol monoethyl ether, specifically, a compound called bis-ethoxydiglycol succinate, which is represented by the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13th Edition, Volume 1, CTFA, 2010, pp. 331 - 332): BIS-ETHOXYDIGLYCOL SUCCINATE are mentioned.

[0031] In addition, in the present invention, specific examples of the bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate include, for example, "Neosolue-Aqulio (trade name)" manufactured by Nippon Fine Chemical Co., Ltd. Specific examples of the bis-ethoxydiglycol succinate include, for example, "HyAquaStar DCS (trade name)" manufactured by Kao Alcohol Industries Co., Ltd.

[0032] These dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more.

[0033] Among these dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters, particularly when hydrogenated lecithin or lipopeptide is used as the component (A), it is preferable to use cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol from the viewpoint of further suppressing the tight feeling due to insufficient moisturization.

[0034] The dicarboxylic acid dialkoxyalkyl ester used in the present invention is a diester compound of a dicarboxylic acid and an alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound of dicarboxylic acid dialkoxyalkyl include, for example, oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid, and the like. Further, examples of the alkoxy alcohol constituting the diester compound include 2-methoxyethanol, 2-ethoxyethanol, and the like.

[0035] Among these dicarboxylic acid dialkoxyalkyl esters, from the viewpoint of better reducing skin irritation and detergency, preferably, a diester compound of succinic acid and 2-ethoxyethanol, specifically, diethoxyethyl succinate, can be mentioned.

[0036] These dicarboxylic acid dialkoxyalkyl esters may be used alone or in combination of two or more.

[0037] The (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 used in the present invention is not particularly limited, and examples include "Neosolue-Aqua (trade name)", "Neosolue-AquaS (trade name)" manufactured by Nippon Fine Chemical Co., Ltd.

[0038] The content of component (B) in the skin cleansing spray of the present invention is not particularly limited, and for example, 0.1% by weight or more can be mentioned. From the viewpoint of obtaining better detergency and / or further reducing the tight feeling due to insufficient moisturization, the content of component (B) is preferably 0.5% by weight or more, more preferably 1.5% by weight or more, and still more preferably 2% by weight or more. The upper limit of the content range of component (B) is not particularly limited, but from the viewpoint of the stability of the skin cleansing spray, etc., for example, 5% by weight or less, preferably 4% by weight or less, and more preferably 3% by weight or less can be mentioned.

[0039] In the skin cleansing spray of the present invention, the ratio of component (A) to component (B) is not particularly limited and is determined by the respective contents described above. From the viewpoints of reducing skin irritation and obtaining better detergency, for example, component (B) is 0.1 to 100 parts by weight, preferably 1 to 80 parts by weight, per 1 part by weight of component (A). Further, from the viewpoint of obtaining even better detergency, component (B) is 1 to 4 parts by weight, more preferably 1 to 2 parts by weight, per 1 part by weight of component (A). From the viewpoint of further suppressing the tight feeling due to insufficient moisturization, it is 1.2 to 80 parts by weight, more preferably 2 to 80 parts by weight. Furthermore, when component (A) is lecithin or lysophosphatidylcholine, from the viewpoint of obtaining even better detergency, component (B) is 1 to 4 parts by weight per 1 part by weight of component (A). From the viewpoint of further suppressing the tight feeling due to insufficient moisturization, component (B) is 2 to 80 parts by weight per 1 part by weight of component (A). From the viewpoint of further suppressing skin irritation, component (B) is 1.2 to 80 parts by weight per 1 part by weight of component (A). When component (A) is saponin, from the viewpoint of obtaining even better detergency, component (B) is 1 to 2 parts by weight per 1 part by weight of component (A).

[0040] Other components In addition to the above components, the skin cleansing spray of the present invention may contain other bases and additives required for formulation and the like, as long as the effects of the present invention are not impaired. Such additives are not particularly limited as long as they are pharmaceutically acceptable. Examples include aqueous bases such as water, lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, etc.), and polyhydric alcohols (ethylene glycol, 1,3-butylene glycol (BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin, etc.); preservatives (phenoxyethanol, methylparaben, propylparaben, benzoic acid, sodium benzoate, sorbic acid, etc.), fragrances (citral, 1,8-cineole, citronellal, farnesol, etc.), colorants (tar dyes (brown No. 201, blue No. 201, yellow No. 4, yellow No. 403, etc.), cocoa pigment, chlorophyll, aluminum oxide, etc.), thickeners (hydroxypropyl cellulose, hydroxyethyl cellulose, cross-linked acrylic acid polymer, carboxyvinyl polymer, hypromellose, polyvinyl pyrrolidone, sodium alginate, ethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, carrageenan, etc.), pH adjusters (phosphoric acid, hydrochloric acid, citric acid, sodium citrate (trisodium citrate), succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), wetting agents (sodium dl-pyrrolidone carboxylate solution, D-sorbitol solution, macrogol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, ultraviolet absorbers, chelating agents, adhesives, buffers, solubilizing aids, solubilizers, preservatives, and other additives. These base materials and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.

[0041] In addition to the above components, the skin cleansing spray of the present invention may contain other pharmacological components as necessary, as long as the effects of the present invention are not impaired. Examples of such pharmacological components include vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, niacins, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, propoxycaine, meprilocaine or salts thereof, orthocaine, oxyeserine, oxy polyethoxydecane, rosemary extract, percamide peroxide, tesic decitin, etc.), anti-inflammatory agents (indomethacin, felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protectants (collodion, castor oil, etc.), blood circulation promoting components (nonyl vanillylamide, benzyl nicotinate, capsaicin, pepper extract, etc.), cooling agents (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (sodium chondroitin sulfate, glucosamine, hyaluronic acid, cationized hyaluronic acid (such as hyaluronic acid dihydroxypropyltrimonium, etc.)), and the like. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of pharmacological component used, the expected effect, and the like.

[0042] Form The form of the skin cleansing spray of the present invention is liquid or gel-like at normal temperature. In addition, the viscosity of the skin cleansing spray of the present invention is 10,000 mPa·s or less at 20°C, preferably 5,000 mPa·s or less. The viscosity is a value measured by a BL viscometer (rotor No3, 6 rpm, 20°C).

[0043] Container The container for housing the skin cleansing spray agent of the present invention is not particularly limited as long as it is a spray-type container. The spray-type container in the present invention discharges the content in a mist state, which is different from a pump foamer container that discharges the skin cleansing agent composition in a foamy state.

[0044] In the present invention, by housing the skin cleansing spray agent in a spray-type container in this way, the skin cleansing spray agent is directly applied to the skin by spraying without foaming before application to the skin. Therefore, the application to the skin is easy and physical friction caused by hands or the like during application can be avoided. Examples of the spray-type container include a pump-type spray container that is a non-aerosol spray container and an aerosol spray container. Examples of the diameter (nozzle inner diameter) of the spray-type container include 0.01 to 3 mmφ, preferably 0.1 to 1 mmφ. Examples of the injection amount per push when the spray-type container is a pump-type spray container include 0.05 to 1.2 g, preferably 0.1 to 0.3 g.

[0045] Use The skin cleansing spray agent of the present invention is used to remove body fluids such as skin oil and sweat, and dirt, etc., and is not used as makeup remover (cleansing). The skin cleansing spray agent of the present invention is used by applying it directly to the skin without diluting it with water and without foaming. The amount used per time depends on the concentration of the surfactant, the degree of dirt, etc., but for example, when used for face washing, it is 0.5 to 3 g, preferably 1 to 2 g.

[0046] More specifically, the skin cleansing spray agent can be directly applied to the part to be cleaned by spraying from a spray container without being taken by hand. In this way, by directly applying the skin cleansing spray agent to the part to be cleaned, it is possible to clean only by utilizing the mechanical force of the liquid flow without giving any physical friction such as the friction generated between the skin of the part to be cleaned and the hand or the friction generated between the skin of the cleaning part and the bubbles. Since the skin cleansing spray agent of the present invention has a formulation excellent in detergency, by cleaning using the mechanical force of the liquid flow without giving such physical friction, the burden on the skin during cleaning is significantly reduced, and an extremely gentle cleaning method becomes possible. Such a non-foaming cleaning method enables quick cleaning, makes it easy to feel that there is less surfactant and it is gentle on the skin, and also easily satisfies consumers who have a high awareness of pursuing skin-friendly cleaning. Incidentally, the skin cleansing spray agent of the present invention is particularly suitable for a cleaning method that does not give physical friction to the skin as described above, but does not exclude a usage method in which after applying the skin cleansing spray agent to the part to be cleaned, rubbing is performed using hands or the like.

[0047] The part to be cleaned by the skin cleansing spray agent of the present invention is not particularly limited because any body part can be cleaned, and examples include hands, hair, scalp, body, face, etc. Since the skin cleansing spray agent of the present invention is applied to the part to be cleaned by spraying, it is suitable for use on the hair, scalp, and body from the viewpoint of ease of application. In addition, since the skin cleansing spray agent of the present invention can exhibit excellent detergency without foaming in advance, it is suitable for use on the face, which is sensitive to irritation.

[0048] After cleaning, the skin cleansing spray agent can be rinsed off with water. When rinsing off with water, it may be performed in the same manner as normal face washing, but from the viewpoint of reducing the burden on the skin, it is preferable to rinse off using the mechanical force of the water flow without applying friction by hand.

[0049] In addition, since the surfactant concentration of the skin cleansing spray agent of the present invention can be extremely low, in this case, it is not necessary to rinse it off after washing. Therefore, the skin cleansing spray agent of the present invention is also suitable for use in wiping applications in hospitals, skin cleansing procedures such as face washing in esthetic salons and beauty parlors, and disaster relief supplies applications. When not rinsed off, the skin cleansing spray agent remaining on the cleansing site may be absorbed and removed using a water-absorbent base material such as a towel or tissue.

[0050] Manufacturing method The skin cleansing spray agent of the present invention is produced by mixing the aforementioned components (A) and (B), and other components that are blended as necessary, preparing them in a predetermined form, and then storing them in a spray container. When stored in an aerosol spray container as the spray container, it is produced by storing it together with a propellant such as gas.

Examples

[0051] Examples are shown below to more specifically explain the present invention, but the present invention is not limited thereto.

[0052] Test example Skin cleansing spray agents having the compositions shown in Tables 1 to 4 were prepared. The details of each component shown in Tables 1 to 4 are as follows. The skin cleansing spray agents shown in Tables 1 to 4 are liquid, and the viscosity at 20 °C (measured with a BL viscometer (Brookfield B-type viscometer), rotor No3, 6 rpm) was all in the range of 5000 mPa·s or less. · Lysophosphatidylcholine: Lysophosphatidylcholine Kyowa (manufactured by Kyowa Hakko Bio Co., Ltd.) · Lecithin: Basis LP-20 (manufactured by Nisshin Oillio Group, Ltd.) · Hydrogenated lecithin: Basis LP-20H (manufactured by Nisshin Oillio Group, Ltd.) · Saponin: Soapnut extract powder (manufactured by Ichimaru Pharcos Co., Ltd.) (saponin content 20% by weight) · Sodium surfactin: Kaneka surfactin (manufactured by Kaneka Corporation) · Bis(2-(2-ethoxyethoxy)ethyl) cyclohexane-1,4-dicarboxylate (Neosolue-Aqulio (trade name) manufactured by Nippon Fine Chemical Co., Ltd.) · Bis(2-(2-ethoxyethoxy)ethyl) succinate (Hi Aquaster DCS (trade name) manufactured by Kao Alcohol Industries Co., Ltd.)

[0053] <Evaluation of detergency> Regarding the prepared skin cleansing spray agents, 10 professional cosmetic evaluation panelists conducted a detergency evaluation. Specifically, each skin cleansing spray agent was contained in a pump-type spray container (Z-155-C110 (trade name) manufactured by Takemoto Container Co., Ltd., with an injection volume of 0.15 g per push), and 1.5 g was applied by directly spraying it onto the face. After leaving it for about 5 seconds, it was then rinsed off with water without touching the face with hands. After blotting the face with a towel to absorb the water, the feeling of dirt removal from the skin was scored by conducting a sensory evaluation based on the following criteria.

[0054] 5 points: The feeling of dirt removal was strongly felt. 4 points: The feeling of dirt removal was felt. 3 points: Neither. 2 points: The feeling of dirt removal was hardly felt. 1 point: The feeling of dirt removal was not felt at all.

[0055] The total scores obtained by the 10 panelists were summed up, and the degree of detergency was evaluated according to the following classification. The results are shown in Tables 1 to 4. ◎: 45 points or more ○: 40 points or more and less than 45 points △: 35 points or more and less than 40 points ×: Less than 35 points

[0056] <Evaluation of tight feeling> For the prepared skin cleansing spray, 10 professional cosmetic evaluation panelists conducted a tightness sensory evaluation. Specifically, each skin cleansing spray was contained in a pump-type spray container ("Z-155-C110 (product name)" manufactured by Takemoto Container Co., Ltd., with an injection volume of 0.15 g per push), and 1.5 g was applied by directly spraying it onto the face. After leaving it for about 5 seconds, it was then rinsed off with water without touching the face with hands. After blotting the water on the face with a towel, the tightness was scored by conducting a sensory evaluation based on the following criteria. The stronger the degree of tightness, the more it indicates insufficient moisturization.

[0057] 5 points: No feeling of tightness at all 4 points: Almost no feeling of tightness 3 points: Slight feeling of tightness 2 points: Feeling of tightness 1 point: Strong feeling of tightness

[0058] The scores obtained by the 10 panelists were totaled, and the degree of tightness was evaluated according to the following classification. The results are shown in Tables 3 to 4. ◎: 45 points or more ○: 40 points or more and less than 45 points △: 35 points or more and less than 40 points ×: Less than 35 points

[0059] <Cultured Epidermal Skin Irritation Test (In Vitro Evaluation of Skin Irritation)> For the prepared skin cleansing spray, the cultured epidermal skin irritation test was conducted as follows. 1. Preparation of the cultured epidermal model LabCyte EPI-MODEL24 The assay medium was warmed and 0.5 mL was added to each well of a 24-well assay plate. The cultured epidermal model LabCyte EPI-MODEL24 (lot number: LCE24-180226-A) was transferred to the 24-well assay plate with the assay medium added. It was confirmed that there were no bubbles on the bottom surface of the culture cup, and it was placed in a CO 2 incubator and left standing for 1 hour or more until the test substance was exposed.

[0060] 2. Application and Washing of Test Substances Among the 24 epidermal models, 12 were used (the rest were continuously pre-cultured until this test). The 24-well assay plate was taken out of the CO 2 incubator. The assay medium was warmed and 1.0 mL was added to each well in the third row of the 24-well assay plate. The test substance (each skin cleansing spray agent) was dropped onto the cultured epidermis in the culture cup at 25 μL without using a pump-type spray container, and was spread over the whole to be exposed. At 1 minute, 5 minutes, and 10 minutes after exposure, the test substance was removed by suction, and the cultured epidermal model in the cup was washed with phosphate buffer solution (PBS) and transferred to the third row of the 24-well assay plate.

[0061] 3. MTT Test The MTT test is a method of measuring the viable cell rate by measuring the absorbance at 570 nm of formazan dye produced by the reduction of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromi de] taken up into cells by dehydrogenase in mitochondria in the cells by extracting it with an organic solvent.

[0062] 10 mL of MTT medium was prepared at a final concentration of 0.5 mg / mL. The MTT medium was warmed and 0.5 mL was added to each well in the fourth row of the 24-well assay plate. The cultured epidermal model was transferred to the fourth row of the 24-well assay plate and placed in a CO2 incubator for a 3-hour MTT reaction. After the MTT reaction was completed, the cultured skin was picked up with forceps and transferred to a 1.5 mL microtube. 300 μL of isopropanol was put into the microtube to completely immerse the cultured epidermal model. Then, it was left standing for 2 hours, and the microtube was vortexed to extract the dye. The extract (200 mL) was put into each well of a 96-well plate. Also, as a blank (negative control), 200 μL of isopropanol was put into A1. The absorbances at 570 nm and 650 nm were measured with a microplate reader. The value obtained by subtracting the absorbance at 650 nm from the absorbance at 570 nm was used as the measured value, and the viable cell rate of the test substance was calculated from the following formula.

[0063]

Number

[0064] The viable cell rate was classified based on the following criteria, and the skin irritation was evaluated. The results are shown in Tables 3 to 4. ◎: 90% or more ○: 75% or more and less than 90% △: 65% or more and less than 75% ×: 50% or more and less than 65% ××: Less than 50%

[0065] As shown in Tables 1 to 4, spray agents for skin cleansing containing a surfactant at a concentration of more than 2% by weight (Comparative Examples 13 to 16) showed skin irritation, and spray agents for skin cleansing containing a natural surfactant at a concentration of 0.025 to 2% by weight (Comparative Examples 1 to 10) did not show detergency. In contrast, spray agents for skin cleansing (Examples 1 to 21) containing an amphiphilic ester (Comparative Examples 11 to 12) that does not show detergency alone together with a natural surfactant at a concentration of 0.025 to 2% by weight were able to obtain excellent detergency only by applying directly to the skin by spraying from a spray container without applying any physical friction and only by utilizing the mechanical force of the liquid flow. That is, it was shown that gentle cleansing of the skin is possible. Moreover, as shown in Examples 4 to 7, 9, 11, 15, 17 to 21, it was shown that in the spray agent for skin cleansing of the present invention, the detergency was improved while suppressing skin irritation and the tight feeling due to insufficient moisturization. That is, it was shown that by setting the concentration of the natural surfactant in the spray agent for skin cleansing applied directly to the skin by spraying to 0.025 to 2% by weight, gentle cleansing of the skin is possible both physically and chemically.

[0066]

Table 1

[0067]

Table 2

[0068]

Table 3

[0069]

Table 4

Claims

1. A skin (excluding the scalp) cleansing spray (excluding shampoo) contained in a spray container and used in a non-foaming washing method, which contains (A) a surfactant and (B) dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester, wherein the component (A) consists of a naturally-derived surfactant selected from the group consisting of lysophosphatidylcholine, phosphatidylcholine, hydrogenated phosphatidylcholine, saponin, and surfactin and its salts, and the content of (A) is 0.025 to 2% by weight.

2. The skin cleansing spray according to Claim 1, wherein the spray container is a pump-type spray container.

3. The skin cleansing spray according to Claim 1, wherein the spray container is an aerosol-type spray container.

4. The skin cleansing spray according to any one of Claims 1 to 3, wherein the dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.

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