Toothpaste composition

Abstract

To provide a dentifrice composition containing a water-soluble polyvalent metal salt that is easy to put on a tooth brush and has excellent moldability, and has excellent dischargeability from a container even after storage.SOLUTION: A dentifrice composition contains (A) at least one water-soluble polyvalent metal salt selected from water-soluble aluminum salt, water-soluble copper salt and water-soluble zinc salt, (B) xanthan gum, and (C) a cationic polymer compound. The dentifrice composition may further contain an abrasive with its content being 15 mass% or less.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a dentifrice composition containing a water-soluble polyvalent metal salt, which is easily placed on a toothbrush, has excellent moldability, and has excellent dischargeability from a storage container even after storage.

Background Art

[0002] Water-soluble polyvalent metal salts such as aluminum salts, copper salts, and zinc salts are medicinal components that can be incorporated into dentifrice compositions. Depending on the component, they have an effect of suppressing tooth sensitivity, an effect of suppressing bad breath, an effect of tightening the gums, etc., and are effective in preventing or suppressing oral diseases. However, when these water-soluble polyvalent metal salts are incorporated, they tend to adversely affect the general physical properties of the dentifrice composition, and depending on the binder, sufficient moldability and water retention may not be obtained, making it difficult to place the composition on a toothbrush. To improve the ease of placement on a toothbrush, xanthan gum, which is a salt-resistant polymer substance, is used as a binder. In Patent Document 1 (Japanese Patent No. 5573120), xanthan gum and powdered cellulose are incorporated into a dentifrice composition containing a copper or zinc compound to improve the ease of placement on a toothbrush and prevent liquid separation and muscle deterioration after long-term storage. Further, in Patent Document 2 (Japanese Patent No. 5790455), an anionic surfactant, propylene glycol alginate, and xanthan gum are used in combination to improve the foaming and liquid separation stability of a dentifrice composition containing aluminum lactate.

[0003] By the way, for patients with oral diseases such as tooth sensitivity, the less irritation to the gums during toothbrushing, the more likely they are to continue using it, which also leads to an improvement in the effect. Therefore, it is more effective for a dentifrice composition containing a water-soluble polyvalent metal salt to be less irritating. However, if the amount of abrasive is reduced to design a dentifrice composition with low irritation and a good polishing feel, the moldability deteriorates and it becomes difficult to place the composition on a toothbrush. On the other hand, if the amount of binder is increased, for example, to maintain the moldability, it tends to harden over time and make it difficult to discharge from the storage container. It has been even more difficult to maintain these physical properties in a dentifrice composition containing a water-soluble polyvalent metal salt.

Prior Art Documents

Patent Documents

[0004] [Patent Document 1] Japanese Patent No. 5573120 [Patent Document 2] Japanese Patent No. 5790455 [Summary of the Invention] [Problems to be Solved by the Invention]

[0005] For this reason, there is a demand for a dentifrice composition that contains a water-soluble polyvalent metal salt, has its medicinal effects (such as suppressing hypersensitivity), is easy to place on a toothbrush, has good dischargeability from the storage container even after storage, and is excellent in both of the above characteristics even when the blending amount of the abrasive is relatively small. However, it has been difficult for conventional techniques to satisfy all of these requirements.

[0006] The present invention has been made in view of the above circumstances, and an object thereof is to provide a dentifrice composition containing a water-soluble polyvalent metal salt that is easy to place on a toothbrush, has excellent moldability, and has excellent dischargeability from the storage container even after storage. [Means for Solving the Problems]

[0007] As a result of intensive studies to achieve the above object, the present inventors have found that when a cationic polymer compound is blended into a dentifrice composition in which a specific water-soluble polyvalent metal salt and xanthan gum are blended, it is easy to place on a toothbrush and has excellent moldability. Moreover, by using xanthan gum and a water-soluble polyvalent metal salt in combination, hardening of the composition (dentifrice composition) over time is prevented, it is easy to discharge from the storage container even after storage, it has excellent dischargeability from the storage container, and even when the amount of the abrasive is relatively small and the composition is low in irritation, it is excellent in both of the above characteristics. That is, in the present invention, a dentifrice composition containing (A) at least one water-soluble polyvalent metal salt selected from a water-soluble aluminum salt, a water-soluble copper salt, and a water-soluble zinc salt, (B) xanthan gum, and (C) a cationic polymer compound has effects such as suppressing tooth sensitivity and suppressing bad breath by the component (A), is easy to place on a toothbrush, has excellent moldability, and has excellent dischargeability from a storage container even after storage. The present invention has been made based on these findings.

[0008] When a water-soluble polyvalent metal salt (A) is blended in a dentifrice composition and xanthan gum (B) is blended as a binder to improve the difficulty of placing it on a toothbrush, especially when the blending amount of the abrasive is reduced to, for example, 15% by mass or less, as the blending amount of the component (B) increases, the cationic polyvalent metal salt adsorbs to xanthan gum over time and gelation occurs, resulting in hardening, the composition hardens, and the dischargeability from a storage container, for example, a tube container, deteriorates after storage. A problem specific to the component (B) occurred, and it was not possible to ensure the dischargeability from the storage container and to give an appropriate moldability that is easy to place on a toothbrush. However, when the component (C) is combined and blended with the component (B), the component (C) prevents the composition from hardening over time due to the components (A) and (B), and the above problems are also solved, and excellent moldability that is easy to place on a toothbrush and excellent dischargeability that is easy to discharge from the storage container even after storage can be imparted. Therefore, the dentifrice composition of the present invention is excellent in both of the above characteristics even when the blending amount of the abrasive is relatively small, is easy to place on a toothbrush, is easy to discharge from a storage container, and can give effects such as suppressing tooth sensitivity by the component (A) under a low irritation and pleasant polishing feeling.

[0009] The effects of the present invention are specific effects of the combination of the components (A), (B), and (C). When the component (C) is not blended, the dischargeability from the storage container after storage is poor. Even when the component (C) is blended, if the component (B) is not blended, it becomes difficult to place it on a toothbrush, and the effects are inferior to the present effects. As shown in the comparative examples described below, in Comparative Examples 1 to 3 in which the component (B) was not blended, the ease of mounting on the toothbrush was poor. In these examples, even when the component (C) or the thickener carrageenan or sodium polyacrylate was added, no deterioration in the discharge property from the tube container after storage was observed and it was easy to extrude. Further, in Comparative Examples 4 to 7 in which the component (C) was not blended, even when hydroxyethyl cellulose, which is a non-cationic cellulose derivative, and further sodium carboxymethyl cellulose were blended, the ease of extrusion from the tube container after storage was poor. On the other hand, as shown in the examples described below, the dentifrice composition containing the components (A), (B) and (C) was excellent in both the ease of mounting on the toothbrush and the ease of extrusion from the tube container after storage (after storage at 60° C. for 1 month).

[0010] Therefore, the present invention provides the following dentifrice composition. [1] (A) At least one water-soluble polyvalent metal salt selected from water-soluble aluminum salts, water-soluble copper salts and water-soluble zinc salts, (B) xanthan gum and (C) a cationic polymer compound A dentifrice composition characterized by containing. [2] The dentifrice composition according to [1], wherein the water-soluble aluminum salt is selected from aluminum lactate, potassium aluminum sulfate, aluminum sulfate and aluminum nitrate, the water-soluble copper salt is selected from copper gluconate, copper sulfate, copper citrate and copper chlorophyllin, and the water-soluble zinc salt is selected from zinc gluconate and zinc chloride. [3] The dentifrice composition according to [1] or [2], wherein the cationic polymer compound is cationized cellulose. [4] The dentifrice composition according to [3], wherein the cationized cellulose is selected from hydroxyethyl cellulose dimethyldiallylammonium salt and O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethyl cellulose chloride. [5] A dentifrice composition according to any one of [1] to [4], wherein the content of component (A) is 0.1 to 5% by mass. [6] A dentifrice composition according to any one of [1] to [5], wherein the content of component (B) is 0.1 to 3% by mass. [7] A dentifrice composition according to any one of [1] to [6], wherein the content of component (C) is 0.03 to 2% by mass. [8] A dentifrice composition according to any one of [1] to [7], wherein (C) / (B) is 0.01 or more as a mass ratio. [9] Furthermore, a dentifrice composition according to any one of [1] to [8], which contains an abrasive and the content thereof is 15% by mass or less.

[10] A dentifrice composition according to any one of [1] to [8], which is a paste dentifrice composition. [Advantages of the Invention]

[0011] According to the present invention, there can be provided a dentifrice composition having effects such as suppression of tooth hypersensitivity, suppression of bad breath, and squeezing of gums by component (A), excellent moldability, easy to place on a toothbrush, and suppression of hardening over time and excellent dischargeability from a storage container even after storage. This dentifrice composition can be formulated into a dentifrice composition in which the physical properties of the dentifrice composition are satisfactorily maintained, and moreover, a low irritation and gentle polishing feeling is ensured with a relatively small amount of abrasive or without containing an abrasive. It is particularly useful for suppressing tooth hypersensitivity or bad breath and for squeezing gums. [Embodiments for Carrying Out the Invention]

[0012] Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention contains (A) one or more water-soluble polyvalent metal salts selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts, (B) xanthan gum, and (C) a cationic polymer compound.

[0013] (A) The water-soluble polyvalent metal salt is selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts. These can be used alone or in combination of two or more. As the water-soluble aluminum salt, aluminum lactate having a perception hypersensitivity inhibitory effect, potassium aluminum sulfate having a gingival squeezing effect, aluminum sulfate, aluminum nitrate, etc. can be used. As the water-soluble copper salt, copper gluconate having a halitosis inhibitory effect and a gingival squeezing effect, copper sulfate, copper citrate, copper chlorophyllin, etc., and as the water-soluble zinc salt, zinc gluconate having a halitosis inhibitory effect and a gingival squeezing effect, zinc chloride, etc. can be used. These water-soluble polyvalent metal salts can use commercially available products.

[0014] (A) The blending amount of the water-soluble polyvalent metal salt is preferably 0.1 to 5% (mass%, the same hereinafter) of the whole composition, more preferably 0.1 to 3.5%. Furthermore, when a water-soluble aluminum salt is blended as the component (A), its preferable blending amount is 0.1 to 5% of the whole composition, particularly 0.5 to 3.5%. When a water-soluble copper salt and a water-soluble zinc salt are blended as the component (A), their preferable blending amounts are 0.1 to 1% of the whole composition, particularly 0.1 to 0.5%. When the blending amount of the component (A) is within the above range, the ease of mounting on the toothbrush and the dischargeability from the storage container after storage can be made sufficiently excellent. Note that if the blending amount of the component (A) is too much, a sense of irritation derived from itself may appear.

[0015] (B) Xanthan gum has an effect of moderately maintaining moldability and improving the ease of mounting on a toothbrush. As xanthan gum, commercially available products such as Monaat Gum DA (manufactured by DSP Gohsei Hood & Chemical Co., Ltd.) can be used. (B) The blending amount of xanthan gum is preferably 0.1 to 3% of the whole composition, more preferably 0.5 to 1.5%. When the blending amount is 0.1% or more, the moldability of the preparation is appropriately maintained and the ease of mounting on the toothbrush is sufficiently improved. If the blending amount of component (B) is too large, the drawability may deteriorate, or the preparation may become too hard and the usability may decrease.

[0016] (C) The cationic polymer compound prevents the hardening of the composition over time caused by the combined use of components (A) and (B), and has an effect of improving the discharge property, making it easier to discharge the composition by extruding it from the storage container even after storage. Examples of the cationic polymer compound include cationized cellulose, cationized guar gum, homopolymer of dimethyldiallylammonium, copolymer of dimethyldiallylammonium chloride and a polymerizable monomer having an ethylenically unsaturated hydrocarbon group, cationized polyvinylpyrrolidone, cationized polyamide, cationized polymethacrylate, cationized polyacrylamide, copolymer of cationized methacrylate and acrylamide, copolymer of cationized methacrylate and methacrylate, polyethyleneimine, cationized starch, cationized amylose, cationized roasted bean gum, cationized agar, etc. Among them, cationized cellulose and cationized guar gum (for example, O-{2-hydroxy-3-(trimethylammonio)propyl} guar gum chloride, etc.) are preferable, and cationized cellulose is more preferable.

[0017] Examples of cationized cellulose include those obtained by adding a dimethyldiallylammonium chloride, 2-hydroxy-3(trimethylammonio)propyl group, etc. as a cationic group to a cellulose derivative. For example, hydroxyethylcellulose dimethyldiallylammonium salts such as hydroxyethylcellulose dimethyldiallylammonium chloride, O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose, etc. can be used. Particularly in terms of the discharge property from the storage container after storage, hydroxyethylcellulose dimethyldiallylammonium salt is preferable.

[0018] The nitrogen content of the cationic polymer compound is preferably 0.1 to 3%, more preferably 0.5 to 2.5%. The weight average molecular weight of the cationic polymer compound is preferably 250,000 to 1,500,000 in terms of the weight average molecular weight (the same hereinafter) by gel permeation chromatography (GPC) method using polyethylene glycol as a standard substance, from the viewpoint of the discharge property from the storage container after storage. The viscosity of the cationic polymer compound in a 2% aqueous solution at 21°C is preferably 30 to 3,000 mPa·s, more preferably 35 to 350 mPa·s. The above viscosity was measured using a BH-type Brookfield viscometer (rotor No. 2, 20 rotations, measurement time 1 minute) for a 2% aqueous solution of the cationic polymer compound at 21°C (the same hereinafter). As such a cationic polymer compound, commercially available products can be used. Specifically, as hydroxyethyl cellulose dimethyldiallylammonium salt, Cellcoat L-200 (manufactured by NSC Corporation, Japan, weight average molecular weight: 250,000 to 350,000, 2% aqueous solution viscosity at 21°C: 35 to 350 mPa·s), etc. can be mentioned. As O-{2-hydroxy-3-(trimethylammonio)propyl} guar gum chloride, Jaguar C-17 (manufactured by Sankyo Co., Ltd.), etc. can be mentioned.

[0019] (C) The blending amount of the cationic polymer compound is preferably 0.03 to 2% of the whole composition, more preferably 0.05 to 1%, still more preferably 0.1 to 0.5%. When the blending amount is 0.03% or more, the discharge property from the storage container after storage is sufficiently improved and it becomes easy to discharge. When the blending amount is too large, a sense of irritation may appear, and when it is 2% or less, a good feeling of use with sufficient suppression of the sense of irritation can be ensured.

[0020] Furthermore, (C) / (B) indicating the quantitative ratio of component (B) and component (C) is preferably 0.01 or more, particularly 0.06 or more, especially 0.1 or more as a mass ratio, and is 10 or less, particularly 4 or less, especially 2 or less. When the mass ratio of (C) / (B) is within the above range, the ease of mounting on a toothbrush and the discharge property from the storage container after storage are further excellent.

[0021] The dentifrice composition of the present invention is particularly suitable as a dentifrice composition for brushing teeth. In addition to the above components, known components usually used in dentifrice compositions can be blended as necessary within a range not impairing the effects of the present invention. Examples of optional components that can be blended include abrasives, binders, wetting agents, surfactants, sweeteners, fragrances, pH adjusters, preservatives, medicinal components, etc. These components and water can be mixed and prepared by a usual method.

[0022] Examples of the abrasive include silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica; calcium phosphate-based compounds such as dicalcium phosphate dihydrate or anhydrate, monocalcium phosphate, tricalcium phosphate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, etc. One or more of these can be blended. Among these, silicate-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-bonded silica, calcium carbonate-based abrasives, and particularly silica-based abrasives such as precipitated silica are preferred from the viewpoints of abrasiveness, ease of mounting on a toothbrush, and extrudability from a tube container. The silica-based abrasive preferably has a particle size of 1 to 40 μm and a BET specific surface area of 80 to 250 square meters per gram, for example. The blending amount of these abrasives can be 0 to 70% of the whole composition. However, when particularly aiming for a low irritation and excellent polishing feel, it is preferably 15% or less of the whole composition, more preferably 12% or less, and particularly preferably 10% or less. That is, in the present invention, the blending amount of the abrasive is preferably 0 to 15% of the whole composition, particularly preferably 3 to 15%, more preferably 3 to 12%, and still more preferably 5 to 10%.

[0023] Any binder can be an organic binder or an inorganic binder other than components (B) and (C) as long as the effects of the present invention are not impaired. Examples of the organic binder include sodium carboxymethyl cellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methyl cellulose, hydroxyethyl cellulose, tragacanth gum, karaya gum, gum arabic, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, veegum, propylene glycol alginate, etc. The blending amount of any of these organic binders is preferably 0.1 to 5% of the whole composition, particularly 0.1 to 2%. Examples of the inorganic binder include thickening silica, aluminum silicate, etc. The blending amount of these inorganic binders is preferably 0.1 to 10% of the whole composition, particularly 0.5 to 8%. In the present invention, since component (B) and further component (C) also act as binders, the blending amount of binders other than these (any binders) may be 2% or less of the whole composition, particularly 1% or less.

[0024] Examples of the wetting agent include polyhydric alcohols such as propylene glycol, polyethylene glycol, and glycerin, and sugar alcohols such as sorbitol and xylitol. The blending amount of the wetting agent is 5 to 60% of the whole composition, particularly 10 to 50%.

[0025] Examples of the surfactant include anionic surfactants, nonionic surfactants, and amphoteric surfactants. Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfacetates, N-acyltaurates such as N-methyl-N-acyltaurine salts, acyl sarcosinates, acyl amino acid salts such as N-acyl-L-glutamate salts, etc. These can be used alone or in combination of two or more. Among them, acyl amino acid salts and acyl taurine salts are preferred among anionic surfactants because of their low irritation. Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, glycerin fatty acid esters, sucrose fatty acid esters, alkyl glycosides, alkylolamides, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, etc. Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl betaines, fatty acid amide propyl betaines, alkyl imidazolinium betaines, alkyl sulfobetaines, etc. The blending amount of the surfactant is usually 0.01 to 10%, particularly 0.1 to 5% of the whole composition.

[0026] Examples of sweeteners include sodium saccharin, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidil dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartyl phenylalanine methyl ester, etc.

[0027] Examples of flavors include flavors known for oral compositions, such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, bay leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, etc.

[0028] pH adjusters include organic acids such as citric acid and lactic acid and their salts; inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate. Preservatives include paraoxybenzoic acid esters, sodium benzoate, and the like.

[0029] The medicinal ingredients include substances other than component (A), such as enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, allantoin, azulene, glycyrrhizinate, and glycyrrhetinate; cell activators such as sodium chloride and vitamins; bactericides such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, and lysozyme chloride; tartar preventives such as zeolite; blood circulation promoters such as vitamin E; and amino acids such as alanine, glycine, and proline. The blending amount of the medicinal ingredients can be an effective amount as long as it does not interfere with the effects of the present invention.

[0030] Furthermore, as optional ingredients, inorganic compounds such as mica titanium, titanium oxide, and bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds such as polyvinyl acetate, acrylic, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder or their copolymers; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetyl alcohol and stearyl alcohol; polyisobutylene, polybutadiene, polyurethane, silicone, and natural rubber can be blended within a range that does not interfere with the effects of the present invention.

[0031] The dentifrice composition of the present invention has no particular limitation on the container to be filled, and a known tube container can be used. The material of the tube container is not particularly limited, and specifically, single-layer or multi-layer containers such as polyethylene, polypropylene, polyethylene terephthalate, nylon, and aluminum can be used. The tube diameter and the inner diameter of the extraction port are not particularly limited as long as they are within the normal range. For example, the length of the tube body (excluding the extraction port part) is preferably 50 to 160 mm, the outer peripheral length in the width direction is preferably 20 to 120 mm, and the inner diameter of the pouring port is preferably 1 to 10 mm.

Examples

[0032] Hereinafter, examples and comparative examples will be shown to specifically explain the present invention, but the present invention is not limited to the following examples. In the following examples, % indicates mass % unless otherwise specified.

[0033] [Examples, Comparative Examples] Paste dentifrice compositions having the compositions shown in Tables 1 to 4 were prepared by a conventional method and stored in a laminated tube container (length 120 mm, outer circumference 100 mm, extraction port inner diameter 2 mm), and this was used as a sample and evaluated by the following method. The results are also shown in the table. Note that the composition containing aluminum lactate as the component (A) had an effect of suppressing tooth hypersensitivity, and the compositions containing copper gluconate or zinc chloride had an effect of suppressing bad breath and a squeezing effect.

[0034] <Evaluation of Ease of Mounting on a Toothbrush> The moldability of the sample was evaluated by the ease of mounting on a toothbrush. For the sample immediately after preparation, a usability evaluation was conducted by 5 professional panelists as subjects. 1 g of the paste dentifrice composition was extruded from the tube container onto a toothbrush (Clinica Advantage Hub Brush, 4-row compact, ordinary type, manufactured by Lion Corporation), and the ease of mounting on the toothbrush was determined according to the following scoring criteria. The average score of 5 people was obtained and evaluated according to the following evaluation criteria. Scoring Criteria 1: Almost no moldability and very difficult to mount on a toothbrush 2: Low moldability and difficult to mount on a toothbrush 3: Some formability, relatively easy to place on the toothbrush 4: Has formability, quite easy to place on the toothbrush 5: Good formability, very easy to place on the toothbrush Evaluation criteria (Pass if ○ or above) ☆: Average score of 5 people is 4.5 or above ◎: Average score of 5 people is 4 or above and less than 4.5 ○: Average score of 5 people is 3 or above and less than 4 ×: Average score of 5 people is less than 3

[0035] <Evaluation of Ease of Extrusion from the Stored Tube Container> The hardness of the stored sample was evaluated by the ease of extrusion from the above tube container. The sample immediately after preparation was stored at 60 °C for 1 month. After storage, the center of the tube container of the sample was held with a finger and the dentifrice composition was extruded onto paper. The ease of extrusion from the tube container was judged by 5 professional panelists as subjects according to the following scoring criteria. The average score of 5 people was obtained and evaluated according to the following evaluation criteria. The samples immediately after production all had good ease of extrusion from the tube container. Scoring criteria 1: Very difficult to extrude from the tube container 2: Difficult to extrude from the tube container 3: Slightly easy to extrude from the tube container 4: Quite easy to extrude from the tube container 5: Very easy to extrude from the tube container Evaluation criteria (Pass if ○ or above) ☆: Average score of 5 people is 4.5 or above ◎: Average score of 5 people is 4 or above and less than 4.5 ○: Average score of 5 people is 3 or above and less than 4 ×: Average score of 5 people is less than 3

[0036] Note that for (B) xanthan gum, Monaat gum DA (manufactured by DSP Gohou & Chemical Co., Ltd.) was used. For hydroxyethyl cellulose dimethyldiallylammonium chloride as the (C) component, Cellcoat L-200 (manufactured by NSC Japan Co., Ltd.) was used, and for O-[2-hydroxy-3-(trimethylammonio)propyl] guar gum, Jaguar C-17 (manufactured by Sankyo Co., Ltd.) was used.

[0037]

Table 1

[0038]

Table 2

[0039]

Table 3

[0040]

Table 4

Claims

1. A dentifrice composition containing: (A) one or more water-soluble polyvalent metal salts selected from aluminum lactate, copper gluconate, and zinc chloride; (B) xanthan gum; (C) cationized cellulose; and an abrasive, wherein the content of aluminum lactate is 0.1 to 5% by mass, the content of copper gluconate is 0.1 to 1% by mass, the content of zinc chloride is 0.1 to 1% by mass, and the content of the abrasive is 15% by mass or less.

2. The dentifrice composition according to claim 1, wherein the cationized cellulose is selected from hydroxyethyl cellulose dimethyldiallylammonium salt and O-[2-hydroxy-3-(trimethylammonio)propyl] hydroxyethyl cellulose chloride.

3. The dentifrice composition according to claim 1 or 2, wherein the content of aluminum lactate is 0.5 to 5% by mass.

4. The dentifrice composition according to any one of claims 1 to 3, wherein the content of component (B) is 0.1 to 3% by mass.

5. The dentifrice composition according to any one of claims 1 to 4, wherein the content of component (C) is 0.03 to 2% by mass.

6. The dentifrice composition according to any one of claims 1 to 5, wherein (C) / (B) is 0.01 or more by mass ratio.

7. The dentifrice composition according to any one of claims 1 to 6, which is a gel dentifrice composition.

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