Process for producing Form II reduced coenzyme Q10 crystals or crystalline solids thereof

JP7695993B2Active Publication Date: 2025-06-19KANEKA CORP
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Patent Information

Application Number
JP2023508901
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-03-26
Filing Date
2022-03-04
Publication Date
2025-06-19
Estimated Expiration
2042-03-04

AI Technical Summary

Technical Problem

Existing methods for producing Form II reduced coenzyme Q10 crystals are inefficient and may result in low recovery amounts, making them unsuitable for industrial-scale production. Additionally, the oxidation stability of Form II crystals can vary depending on production conditions.

Method used

A method involving the controlled precipitation of Form II reduced coenzyme Q10 crystals in a mixed solution containing alcohol and reduced coenzyme Q10, where Form II crystals are used as seed crystals, and the FTU change rate is maintained at 45 FTU/min or less for 70% or more of the period until the formazin turbidity reaches 1,000 to 10,000, ensuring excellent oxidation stability.

Benefits of technology

This method efficiently produces Form II reduced coenzyme Q10 crystals with excellent oxidation stability, addressing the inefficiencies and stability issues of existing methods and making the process more suitable for industrial-scale production.

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Abstract

The purpose of the present disclosure is to provide a method for efficiently obtaining reduced coenzyme Q10 crystals of Form II that is a stable crystal form, particularly reduced coenzyme Q10 crystals of Form II having excellent oxidation stability, or a crystalline solid thereof.　An embodiment of the present invention is a method for producing reduced coenzyme Q10 crystals of Form II or a crystalline solid thereof, comprising: adding a reduced coenzyme Q10 crystal of Form II as a seed crystal to a liquid mixture containing an alcohol and reduced coenzyme Q10; and precipitating reduced coenzyme Q10 crystals of Form II in the liquid mixture after the addition of the seed crystal. In the precipitation, during not less than 70% of the time in the period in which formazin turbidity units (FTUs) increase from 1,000 to 10,000, the rate of change in FTUs is maintained at not more than 45 FTU / min.
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Citation Information

Patent Citations

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    JP2003089669A

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    WO2003006409A1

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    WO2020045571A1