Oil-in-water type emulsion composition

Abstract

To improve use feelings such as stickiness observed when blending a high proportion of nicotinamide, and also improve precipitation observed during its use or storage, and further improve emulsion stability at sufficiently high temperatures.SOLUTION: An oil-in-water emulsion composition contains following components (A)-(E): (A) nicotinamide of 1-10 mass%, (B) an anionic surfactant, (C) a higher alcohol being solid at 20°C (D), gellan gum and (E) a polyhydric alcohol of 5-25 mass%.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oil-in-water emulsion composition that has an excellent feeling in use without stickiness, an excellent crystal precipitation inhibitory effect, good emulsion stability at high temperatures, and an even more excellent whitening effect.

Background Art

[0002] In recent years, as product concepts for cosmetics, many products have been launched with the aim of improving freckles, wrinkles, sagging, pigmentation, etc. caused by aging, stress, ultraviolet rays, air drying, etc. In particular, changes in skin color such as freckles and pigmentation give an impression of advanced aging, so many people hope to improve them. As an active ingredient, nicotinamide is known to have a whitening effect of preventing pigmentation by inhibiting the transfer of melanin from pigment cells to epidermal cells (Non-Patent Document 1).

[0003] However, it is known that stickiness and roughness occur when a large amount of nicotinamide is blended, and a good feeling in use cannot be obtained (Patent Document 1). In particular, in the case of a topical composition for skin containing 1% by mass or more of nicotinamide, it is known that crystals of nicotinamide precipitate when the contents adhere to the mouth or the cap and then dry, or when they adhere to the side of the container (Patent Documents 2 and 3).

[0004] In contrast, in Patent Document 1, by using a specific branched hydrocarbon and a specific highly extensible oil in combination, the stickiness when a large amount of nicotinamide is blended can be suppressed. However, the content may adhere to the mouth part or the cap and crystals may precipitate, which may prevent smooth opening and closing of the container. In addition, in an oil-in-water emulsion composition, by using an ester of a linear fatty acid and polyethylene glycol as an emulsifier and blending petrolatum, it has been reported that an oil-in-water emulsion composition excellent in use feeling without irritation or stickiness and excellent in crystal suppression effect can be obtained even when 1% or more of nicotinamide is blended (Patent Document 4). However, although a generally good skin external composition has been obtained in Patent Document 4, it is limited to an oil-in-water emulsion containing petrolatum as an essential component and it is difficult to say that it has sufficient versatility. In Patent Document 2, although crystal precipitation is improved by blending a specific cationic polymer, the stickiness increases and the use feeling is not good.

[0005] On the other hand, examples of the water-soluble polymer blended as a thickener for skin external preparations include acrylic acid-based thickeners such as carbomer. However, it is well known that they generally have poor salt resistance and may cause significant viscosity reduction or aggregation depending on the type of electrolyte, leading to poor stability, and various approaches have been developed for technical development. For example, a technique of using specific surfactants (polyoxyethylene-added castor oil and polyoxyethylene-added sorbitol fatty acid ester) to obtain stability at high temperatures as in Patent Document 5 has been disclosed. Furthermore, due to the warming of the climate and the increase in room temperature in summer, a formulation with higher heat resistance than before is required. Specifically, hitherto, stability at 50°C or higher was considered sufficient, but recently, it may be necessary to confirm the storage stability up to about 60°C. Generally, increasing the storage temperature promotes low viscosity and significantly reduces stability. That is, storage at a higher temperature places a greater load on storage stability than storage at a lower temperature.

[0006] By the above, it is possible to exhibit an excellent whitening effect by blending nicotinamide. However, there is no stickiness, the feel in use is excellent, crystallization does not occur, and there is no known oil-in-water type emulsion composition having good emulsion stability even at high temperatures.

Prior Art Documents

Patent Documents

[0007]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

Non-Patent Document 1

Disclosure of the Invention

Problems to be Solved by the Invention

[0008] An object of the present invention is to improve the feel such as stickiness that occurs when a high amount of nicotinamide is blended, precipitation that occurs during use and storage, and further to have sufficient emulsion stability at high temperatures and an excellent whitening effect.

Means for Solving the Problems

[0009] In view of such circumstances, as a result of intensive studies to solve the above problems, the present inventor has found that the following components (A) to (E); (A) Nicotinamide: 1 to 10% by mass (B) Anionic surfactant (C) Higher alcohol that is solid at 20°C (D) Gellan gum (E) Polyhydric alcohol: 5 to 25% by mass It has been found that an oil-in-water emulsion composition containing the above can solve the above problems, and the present invention has been completed.

[0010] The present invention further relates to an oil-in-water emulsion composition in which the blending mass ratio of component (E) to component (A) is (E) / (A)≧2.

[0011] The present invention can further contain (F) a water-soluble whitening agent.

[0012] The present invention is an oil-in-water emulsion composition in which the (F) water-soluble whitening agent is one or more water-soluble whitening agents selected from ascorbic acid derivatives and their salts, tranexamic acid, and arbutin.

Advantages of the Invention

[0013] The oil-in-water emulsion composition of the present invention has no stickiness, has an excellent feel in use, and has excellent effects of suppressing crystal precipitation, emulsification stability at high temperatures, and whitening effects.

Modes for Carrying Out the Invention

[0014] Hereinafter, the present invention will be described in detail. In this specification, "~" means a range including the numerical values before and after it. Also, the numerical values expressed in % are values based on mass unless otherwise specified.

[0015] Component (A) nicotinamide (C6H6NO / molecular weight: 122.12) in the present invention is a water-soluble amide compound of nicotinic acid (vitamin B3, niacin). In the present invention, those extracted from rice bran or synthesized can be blended. Specifically, those listed in the 15th revised Japanese Pharmacopoeia 2008 can be used. In a dissolved state, it is easily soluble in water and ethanol and hardly soluble in diethyl ether. It is also known to be hardly soluble in polyhydric alcohols and oil agents.

[0016] The blending amount of component (A) is 1 to 10% by mass (hereinafter simply abbreviated as “%”). More preferably, it is 2 to 8%. When the blending amount of component (A) is within this range, an effect of improving spots and pigmentation can be obtained. In addition, even if it is blended in an amount exceeding 10%, there is a tendency for the effect to level off, and there is a risk of crystal precipitation when the moisture in the composition evaporates.

[0017] Examples of the anionic surfactant (B) in the present invention include fatty acid salts derived from fatty acids having 12 to 24 carbon atoms such as sodium laurate, potassium palmitate, and arginine stearate; alkyl sulfate ester salts such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfate ester salts such as triethanolamine polyoxyethylene lauryl sulfate; N-acyl sarcosine salts such as sodium lauroyl sarcosine; fatty acid amide sulfonate salts such as sodium N-stearoyl-N-methyl taurine and sodium N-myristoyl-N-methyl taurine; alkyl phosphate salts such as potassium monocetyl phosphate; polyoxyethylene alkyl ether phosphate salts such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; long-chain sulfosuccinate salts such as sodium di-2-ethylhexyl sulfosuccinate; long-chain N-acyl glutamate salts such as sodium N-lauroyl glutamate, sodium N-stearoyl-L-glutamate, arginine N-stearoyl-L-glutamate, sodium N-stearoyl glutamate, and sodium N-myristoyl-L-glutamate. Among these, alkyl phosphate salts and long-chain N-acyl glutamate salts are preferred, and cetyl phosphate salts and stearoyl glutamate salts are more preferred.

[0018] The blending amount of component (B) is not particularly limited, but it is preferably 0.1 to 3%, and more preferably 0.3 to 1%.

[0019] In the present invention, the number of carbon atoms of the higher alcohol that is solid at 20°C in component (C) is not particularly limited, but a linear saturated alcohol having 16 or more carbon atoms is preferred. For example, cetyl alcohol, stearyl alcohol, behenyl alcohol, etc. may be mentioned.

[0020] The blending amount of component (C) is not particularly limited, but it is preferably 0.2 to 5%, more preferably 0.5 to 3%.

[0021] In the present invention, (D) gellan gum is a heteropolysaccharide obtained by pure culture of the bacterium Pseudomonas elodea using glucose as a substrate. As long as it is generally used in the cosmetic field, native gellan gum or deacylated gellan gum can be used without particular limitation. Among these, it is preferable to use native gellan gum.

[0022] The blending amount of component (D) is not particularly limited, but it is preferably 0.01 to 1%, more preferably 0.02 to 0.5%. If the blending amount exceeds 1%, it may become sticky. Commercially available Kelcogel, Kelcogel HM (both from CP Kelco), etc. can also be used.

[0023] In the present invention, the polyhydric alcohol in component (E) is blended to dissolve component (A) and suppress crystal precipitation. Polyhydric alcohol alone has almost no crystal precipitation suppressing effect, but good results can be obtained by using it in combination with (D) gellan gum. Component (E) is not particularly limited as long as it is generally used in external compositions. For example, alkanediols such as 1,3-butylene glycol which is a divalent alcohol may be used, or glycerin, diglycerin which are trivalent or higher alcohols, saccharides or sugar alcohols with many hydroxyl groups may also be used. One or two or more kinds can be appropriately selected and used as necessary.

[0024] The blending amount of component (E) is desirably 25% or less because stickiness is likely to occur in terms of usability when a large amount of polyhydric alcohol is blended. On the other hand, in order to dissolve component (A) and suppress crystal precipitation, component (E) needs to be contained in an amount of 5% or more of the whole composition, and more preferably, it is blended in an amount of 2 times or more that of component (A) so that crystal precipitation can be more effectively suppressed.

[0025] By blending the above components (A) to (E), the oil-in-water type emulsion composition of the present invention can improve skin color changes such as spots and pigmentation, has an excellent usability feeling without irritation or stickiness, and can be made into an oil-in-water type emulsion composition excellent in crystal precipitation suppression effect and high-temperature emulsion stability.

[0026] The present invention can further contain (F) a water-soluble whitening agent. The water-soluble whitening agent is not particularly limited, but the whitening effect can be enhanced by blending one or more water-soluble whitening agents selected from ascorbic acid derivatives and their salts, tranexamic acid, and arbutin.

[0027] In addition to the above components, the oil-in-water type emulsion composition of the present invention can contain optional components usually blended in a normal oil-in-water type emulsion composition within a range that does not interfere with the effects of the present invention, that is, aqueous components, oils, powders, film-forming agents, surfactants, oil-soluble gelling agents, organically modified clay minerals, resins, colorants, ultraviolet absorbers, preservatives, antibacterial agents, fragrances, antioxidants, pH adjusters, chelating agents, beauty components, etc., other than the above essential components.

[0028] The oil-in-water type emulsion composition of the present invention can also be made into various dosage forms by being used in combination with other components. Specifically, it can be implemented in various dosage forms such as liquid, gel, paste, cream, solid, sheet, etc.

[0029] The water-in-oil emulsion composition of the present invention is suitable for preparing quasi-drugs with a high content of nicotinamide, expecting an anti-aging effect, in addition to cosmetics. Specifically, for example, it can be used in lotions, milky lotions, creams, beauty essences, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, etc. The usage methods include using it with hands, fingers, or cotton, impregnating it in non-woven fabrics, etc. and then using it, or aerosolizing it using an aerosol agent.

Examples

[0030] The present invention will be further described in detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the blending amounts are shown in mass% with respect to the system in which the components are blended.

[0031] Experiment 1: Influence of Nicotinamide on the Thickener Using 1% carbomer gel, the viscosity change depending on the blending amount of nicotinamide was confirmed. The results are shown in Table 1. (Experimental method) (1): A 1% carbomer aqueous solution was adjusted to pH 6.5 using potassium hydroxide and gelled to obtain 1% carbomer gel. (2): A predetermined amount of nicotinamide was added to the above 1% carbomer gel, uniformly dissolved, and then left standing at 20°C for 4 hours, and the viscosity was measured. The viscosity reduction degree was calculated based on Equation 1. (Measurement conditions) Measuring instrument: VISCOTESTER TVB-10 manufactured by Toki Sangyo Co., Ltd. Measurement conditions: Rotor M3, rotation speed 12 rpm, after 60 seconds, in a 20°C environment

[0032]

Equation

[0033]

Table 1

[0034] (Discussion) In the low concentration range where the blending amount of nicotinamide did not reach 1%, the viscosity reduction was small. Although nicotinamide is an electrolyte, it was suggested that it has relatively little effect on the viscosity reduction of water-soluble polymer gels sensitive to electrolytes, such as carbomer, which is widely used as a thickening stabilizer in cosmetics. However, this experiment showed that when the blending amount exceeded 1% and reached a high concentration, an obvious viscosity reduction occurred. Therefore, there was a concern that poor stability such as separation would easily occur. In addition, when the same test was conducted using sodium chloride, the results were as follows. The viscosity when 0.1% of sodium chloride, a representative electrolyte, was added to 1% carbomer gel was 35.3 mPa·s (measurement conditions: rotor M1, rotation speed 60 rpm, after 60 seconds, 20°C environment), and the viscosity reduction degree = 99.4%

[0035] The products 1 to 12 of the present invention and the comparative products 1 to 8: oil-in-water emulsions Oil-in-water emulsifying creams with the formulations shown in Table 2 below were prepared, and the stickiness, crystal precipitation inhibition effect, and emulsification stability at high temperature were evaluated by the following methods. In addition, Example 1, Example 2, and Comparative Example 8 evaluated the whitening effect. The results are also shown in Table 2.

[0036] (Evaluation items) Degree of stickiness Crystal precipitation inhibition effect Emulsification stability at high temperature Whitening effect

[0037] (Evaluation methods) [Sensory evaluation method for degree of stickiness] Ten professional panelists who had received sensory evaluation training and were women in their 20s to 40s conducted the evaluation. For each sample, the panelists evaluated the stickiness immediately after applying it to the skin. Five-level evaluation was performed using the following absolute evaluation, the average value was calculated, and the determination was made according to the following four-level determination criteria.

[0038] [Evaluation method for degree of stickiness] (Score): (Evaluation) 5 points: No feeling of stickiness 4 points: Almost no feeling of stickiness 3 points: Slightly sticky 2 points: Sticky 1 point: Very sticky Four - level judgment criteria (Judgment): (Average score) ◎: 4 points or more ○: 3 points or more and less than 4 points △: 2 points or more and less than 3 points ×: Less than 2 points

[0039] [Evaluation method of crystal precipitation inhibition effect] Regarding the evaluation of the crystal precipitation inhibition effect, 4 g of the sample was applied to the bottom of a sterilized petri dish (polystyrene, 90 mm Φ × 15 mm), and left standing in a 30 °C incubator in a free state (without a lid) for 24 hours. Then, each sample was observed under a microscope. The crystal precipitation state was observed using a polarizing filter at 40 times magnification with an optical microscope. <Judgment criteria> (Judgment): (Evaluation) ◎: No crystal precipitation ○: Slight crystal precipitation is observed ×: Obvious crystal precipitation is observed

[0040] [Evaluation method of emulsion stability at high temperature] (Evaluation of emulsion stability) Each sample of Examples 1 - 12 and Comparative Examples 1 - 8 was stored at a temperature of 60 °C for 2 weeks, and the appearance change was visually observed and judged according to the following three - level judgment criteria. Three - level judgment criteria (Judgment): (Evaluation result) ◎: No change, uniform: Very good ○: No change in the first week, but separation is observed after 2 weeks: Good ×: Separation is observed within 1 week: Poor

[0041] [Evaluation method of whitening effect] Twenty women aged from 30 to 50 were divided into two groups. The first group was applied with a sample containing nicotinamide and a water-soluble whitening agent on half of the face (Example 1), and a placebo (Comparative Example 8) on the other half, twice a day. The second group was applied with a sample containing nicotinamide on half of the face (Example 2), and a placebo on the other half, twice a day for 8 consecutive weeks. The front and half-face of the subjects were photographed before and after the consecutive use using a dedicated face photography mini studio VISIA-CR (manufactured by CANFIELD). The photography was carried out with an image correction color chart attached to the forehead of the subject, and the obtained photography images were corrected using the function of Photoshop (Adobe Systems Incorporated) (registered trademark) so that the white balance of the color chart was constant to obtain analysis images. Based on the comparison of the analysis images before and after the consecutive use, the "whitening effect" was evaluated by three professional cosmetics evaluation panels. The evaluation criteria are as follows. The panels were scored according to the following five-level evaluation criteria, and the average value of the scores of all panels was determined according to the following four-level evaluation criteria. (Score) 5 points: Particularly excellent whitening effect 4 points: Excellent whitening effect 3 points: There is a whitening effect 2 points: There is a slight whitening effect 1 point: There is no whitening effect The results are shown based on the following criteria from the average value. (Evaluation criteria) ◎: The average score is 4 points or more ○: The average score is 3 points or more and less than 4 points △: The average score is 2 points or more and less than 3 points ×: The average score is less than 2 points

[0042]

Table 2

[0043] Sodium stearoyl glutamate *1 Amisoft HS-11P Manufactured by Ajinomoto Health Supply Co., Ltd. Potassium cetyl phosphate *2 Amphisol K Manufactured by DSM Nutritional Products Gellan gum *3 manufactured by Kelco Gel HM CP, KELCO (Note: *1, *2, and *3 described below refer to the same substances respectively.)

[0044] Manufacturing method (a): Dissolve and mix 1 to 12 uniformly at 70°C. (b): Add other components sequentially to 25 of purified water and dissolve and mix uniformly at 70°C. (c): Add (a) to (b) and emulsify at 70°C. (d): Stir and cool to 40°C to obtain the target composition.

[0045] As is clear from the results in Table 2, the oil-in-water type emulsified compositions of Examples 1 to 12 of the product of the present invention showed good results in all aspects of non-stickiness, crystal precipitation inhibition effect, and emulsification stability at high temperatures, compared with Comparative Examples 1 to 8. In addition, the whitening effects of Examples 1 and 2 were recognized, and in particular, Example 1 in which a water-soluble whitening agent was blended in addition to nicotinamide showed excellent effects. On the other hand, in Comparative Products 1 and 2 that did not contain (B) an anionic surfactant, significant separation was observed within 3 days in the stability test over time, resulting in a sticky feeling during use. In Comparative Example 3 that did not contain a higher alcohol that was solid at 20°C, and in Comparative Example 4 that used isostearyl alcohol, a branched-chain saturated alcohol that was liquid at 20°C, significant separation was observed by the next day in the stability test over time. In Comparative Example 5 that did not contain gellan gum, crystal precipitation was confirmed, and further significant separation was observed within 3 days. In Comparative Example 6 that used xanthan gum, a general-purpose thickener instead of gellan gum, crystal precipitation and further significant separation were observed within 1 week. For Comparative Example 7 in which ethanol, a monohydric alcohol, was blended instead of a polyhydric alcohol, crystal precipitation occurred. Also, for Comparative Example 8 that did not contain nicotinamide, almost no whitening effect was confirmed.

[0046] Example 13: Oil-in-water type sunscreen cream (Components) (mass%) 1. 1,3 - Butylene Glycol 12.0 2. Diglycerin 3.0 3. Purified Water q.s. 4. Nicotinamide 6.0 5. Methyl Paraben 0.1 6. Sucrose Stearate 1.0 7. (Hydroxyethyl Acrylate / Acryloyldimethyl Taurine Na) Copolymer *4 0.1 8. Gellan Gum *3 0.05 9. 30% Aqueous Solution of Lysine Lauroyl Glutamate Na 0.3 10. Glyceryl Monostearate 1.5 11. Sorbitan Sesquioleate 0.3 12. Hydrogenated Lecithin 0.1 13. Di(Phytosteryl / Octyldodecyl) Lauroyl Glutamate 3.0 14. Diethanolamine Cetyl Phosphate *5 0.5 15. Ethylhexyl Methoxycinnamate 5.0 16. Hexyl Diethylaminohydroxybenzoyl Benzoate 1.0 17. Jojoba Oil 5.0 18. Shea Butter 2.0 19. Squalane 1.0 20. Ceramide 3 0.1 21. Tocopherol 0.05 22. Cetearyl Alcohol 2.0 23. Cholesterol 0.3 24. Coenzyme Q10 0.001 25. Hydrogenated Polyisobutene 2.0 26. 40% Polyacrylamide Solution 0.3 (Hydroxyethyl Acrylate / Acryloyldimethyl Taurine Na) Copolymer *4 SEPINOV EMT10: manufactured by SEPPIC Diethanolamine Cetyl Phosphate*5 AMPHISOL: manufactured by DSM Nutrition

[0047] (Manufacturing method) (a) Uniformly dissolve and mix Components 1 to 9 at 70°C. (b) Uniformly dissolve and mix Components 10 to 25 at 80°C. (c) Add (b) to (a) and emulsify at 70°C. (d) Add 26 to (c) and mix until uniform. (e) Cool to 40°C to obtain an oil-in-water type sunscreen cream.

[0048] The oil-in-water type sunscreen cream of Example 13 was a skin external composition excellent in whitening effect, stickiness, crystal precipitation inhibition effect, and stability over time.

[0049] Example 14: Oil-in-water type emulsified beauty liquid (Components) (mass%) 1. 1,3-Butylene glycol 5.0 2. Dipropylene glycol 5.0 3. Xylitol 3.0 4. Purified water appropriate amount 5. Niacinamide 4.0 6. Gellan gum *3 0.1 7. 92% (acryloyldimethyltaurine ammonium / VP) copolymer / (t-butanol / water mixture)*6 0.1 8. Palm oil fatty acid polyoxyethylene sorbitan (20 E.O.) 0.5 9. Macadamia nut oil fatty acid phytosterol 2.0 10. Cetyl alcohol 3.0 11. Dimethylpolysiloxane (5CS) 3.0 12. Sodium stearoyl glutamate *2 0.2 13. Polyglyceryl-5 myristate 1.0 14. Tocopherol 0.1 15. Stearyl glycyrrhetinate 0.05 16. 10% Sodium hydroxide aqueous solution 0.5 17. Phenoxyethanol 0.2 18. Ethanol 5.0 0.1 of 19.0.3% aqueous solution of water-soluble collagen 0.1 of 20.1% aqueous solution of sodium hyaluronate 0.1 of 21. Jellyfish polysaccharide 10.0 of 22. 10% aqueous solution of sodium ascorbyl phosphate 92% (acryloyldimethyltaurine ammonium / VP) copolymer (t-butanol / water mixture) *6 ARISTOFLEX AVC: manufactured by Clariant

[0050] (Manufacturing method) (a): Components 1 to 8 are uniformly dissolved and mixed at 70°C. (b): Components 9 to 15 are uniformly dissolved and mixed at 80°C. (c): (b) is added to (a) and emulsified at 70°C. (d): After starting the cooling of (c), components 18 to 22 are sequentially added at 45°C, and then cooled to 40°C to obtain an oil-in-water type emulsified beauty liquid.

[0051] The oil-in-water type emulsified beauty liquid of Example 14 was a skin external composition excellent in whitening effect, stickiness, crystal precipitation inhibition effect, and stability over time.

[0052] Example 15: Aqueous moisturizing gel (Components) (mass%) 0.5 of 1. 1,2-Pentanediol 12.0 of 2. 1,3-Butylene glycol 3.0 of 3. Methyl gluceth-10 0.3 of 4. 37.5% (sodium acrylate / sodium acryloyldimethyltaurine) copolymer / isoihexadecane / polysorbate 80 / water mixture *7 0.3 of 5. 5% aqueous solution of polyquaternium-51 0.05 of 6. Gellan gum *3 7. (PEG-240 / decyltetradeceth-20 / HDI) copolymer *8 0.7 3.0 of 8. Niacinamide 9. Tranexamic Acid 2.0 10. Carbomer 0.1 11. 10% Potassium Hydroxide Aqueous Solution 1.0 12. Potassium Cetyl Phosphate *2 0.2 13. Cetyl Alcohol 0.4 14. PEG - 100 Hydrogenated Castor Oil 0.5 15. Ethylhexylglycerin 0.3 16. Purified Water Q.S. 37.5% (Sodium Acrylate / Sodium Acryloyldimethyl Taurate) Copolymer / Isododecane / Polysorbate 80 / Water Mixture *7 SIMULGEL EG QD: manufactured by SEPPIC (PEG - 240 / Decyltetradeceth - 20 / HDI) Copolymer *8 Adekanol GT - 700: manufactured by Adeka

[0053] (Manufacturing Method) (a): First, heat and dissolve Components 12 - 14 in advance. (b): Add (a) and each of Components 1 - 11 to Component 15, mix them, and stir until it becomes transparent and uniform to obtain an aqueous moisturizing gel.

[0054] The aqueous moisturizing gel of Example 15 was a skin - external composition excellent in whitening effect, stickiness, crystal precipitation inhibition effect, and stability over time.

[0055] Example 16: Sheet Mask (Beauty Liquid Impregnated in Non - Woven Fabric) (Components) (mass%) 1. 1,2 - Hexanediol 0.5 2. 1,3 - Butylene Glycol 10.0 3. Methylgluceth - 10 1.0 4. (Acrylates / Alkyl Acrylate (C10 - 30)) Crosspolymer 0.05 5. Gellan Gum *3 0.1 6. Xanthan Gum 0.2 7. PEG / PPG / Polybutylene Glycol - 8 / 5 / 3 Glycerin 0.3 8. Sodium Hyaluronate 0.01 9. Nicotinamide 7.0 10. Octenyl Succinic Starch Al 0.5 11. Dipotassium Glycyrrhizinate 0.1 12. Glycerin 5.0 13. Cetyl Alcohol 0.1 14. Cetyl Phosphate *9 0.1 15. PPG-6 Decyltetradeceth-30 0.5 16. Ethylhexylglycerin 0.2 17. Methylparaben 0.1 18. Purified Water q.s. 19·10% Potassium Hydroxide Aqueous Solution 0.2 Cetyl Phosphate Hostaphat CC100 *9 manufactured by Clariant

[0056] (Manufacturing Method) (a): First, heat and dissolve Components 12 to 17. (b): Add (a) and each of Components 1 to 11 to Component 18, mix, and stir until homogeneous to obtain a beauty liquid. (c): Add 19 to (b) and mix to obtain a stock solution for sheet mask. (d): Impregnate 30 g of this beauty liquid into a non-woven fabric shaped like a face (500 cm2, basis weight 60 g / m2, rayon / polypropylene = 70% / 30%), fill it into an aluminum sheet bag, and adjust the sheet mask.

[0057] The sheet mask of Example 16 had excellent whitening effect, non-greasy feeling, no crystal precipitation during use, and excellent stability over time.

[0058] Example 17: All-in-One Gel (Components) (mass%) 1. Diisostearyl Malate 1.0 2. Behenyl Alcohol 1.0 3. Cetyl Ethylhexanoate 4.0 4. Dimethicone 1.5 5. Squalane 4.0 6. Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 1.0 7. Cocoyl methyl taurine sodium 1.0 8. Sorbitan sesquioleate 0.8 9. Sucrose stearate 2.0 10. Polyglyceryl-10 stearate 1.5 11. PEG-50 hydrogenated castor oil 1.0 12. Tocopherol 0.1 13. Water q.s. 14. 1,3-Butylene glycol 10.0 15. Hydroxypropyl methylcellulose stearoxy ether *10 0.1 16. Glycerin 15.0 17. Carbomer 0.1 18. Gellan gum *3 0.1 19. Propylparaben iodide 0.003 20. Ethylhexylglycerin 0.2 21. Nicotinamide 4.0 22. Phenoxyethanol 0.2 23. Arbutin 3.0 24. Retinol / palmic acid / corn oil mixture 0.001 25. 10% arginine aqueous solution 1.0 26. Sodium glutamate 0.01 27. Creatinine 0.01 28. Peucedanum praeruptorum Dunn extract 0.01 29. Hibiscus flower extract 0.01 30. Hydrolyzed hyaluronic acid 0.01 31. Conyza canadensis (L.) Cronq. leaf extract 0.01 32. Hydrolyzed elastin 0.01 33. Hydrolyzed soybean protein 0.01 34. Mandarin orange peel extract 0.01 35. Lactobacillus / pear juice fermentation broth 0.01 Job's tears seed extract 0.01 37. Gettou leaf extract 0.01 Hydroxypropyl methylcellulose stearoxy ether *10 Sanjelose 60L: manufactured by Daito Kasei Co., Ltd.

[0059] (Manufacturing method) (a): Uniformly dissolve and mix Components 1 to 12 at 70°C. (b): Uniformly dissolve and mix Components 13 to 24 at 80°C. (c): Add (a) to (b) and emulsify at 70°C. (d): After starting cooling of (c), sequentially add Components 25 to 37 at 45°C, and then cool to 35°C to obtain an oil-in-water type emulsified beauty liquid.

[0060] The all-in-one gel of Example 17 was a composition for external use on the skin with excellent whitening effect, stickiness, crystal precipitation inhibition effect, and stability over time.

[0061] Example 18: Oil-in-water type emulsified beauty liquid (beauty liquid containing various extracts) (Components) (mass%) 1. 1,3-Butylene glycol 9.0 2. Diglycerin 5.0 3. Maltose 3.0 4. Purified water appropriate amount 5. Nicotinamide 4.0 6. Gellan gum *3 0.1 7. (Hydroxypropyl methylcellulose stearoxy ether *10 0.1 8. PEG-50 hydrogenated castor oil 2.0 9. Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 2.0 10. Stearyl alcohol 1.0 11. Hydrogenated polyisobutene 3.0 12. Potassium cetyl phosphate *2 0.5 13. Sorbitan sesquioleate 0.8 14. Stearyl Glycyrrhetinate 0.05 15. Tocopherol 0.1 16. Phenoxyethanol 0.2 17. Rose Extract 0.01 18. Cherry Blossom Extract 0.01 19. Lily Extract 0.01 20. Chinese Lantern Plant Extract 0.01 21. Gastrodia Extract 0.01 22. Tea Extract 0.01 23. Angelica Root Extract 0.01 24. Peony Root Extract 0.01 25. Hibiscus Extract 0.01 26. Tormentilla Extract 0.01 27. Baobab Extract 0.01 28. Ilex Extract 0.01 29. Sunflower Extract 0.01 30. Knotweed Extract 0.01 31. Licorice Root Extract 0.01 32. Safflower Extract 0.01 33. Ginseng Root Extract 0.01 34. Job's Tears Extract 0.01 35. Shepherds Purse Extract 0.01 36. Ginkgo Extract 0.01 37. Jojoba Extract 0.01 38. Terminalia Extract 0,01 39. Chickweed Extract 0.01 40. Corn Extract 0.01 41. Arrowhead Vine Extract 0.01 42. Pomegranate Extract 0.01 43. Dandelion Extract 0.01 44. Rose Hip Extract 0.01 45. Evening Primrose Extract 0.01 46. Chamomile Extract 0.01 47. Soybean Extract 0.01 48. White Clover Extract 0.01 49. Mandarin Orange Extract 0.01 50. Licorice extract 0.01 51. Black carrot extract 0.01 52. White strawberry extract 0.01 53. Himalayan raspberry extract 0.01 54. Nemunoki extract 0.01 55. Sweet marjoram extract 0.01 56. Modama extract 0.01 57. Comfrey leaf extract 0.01 58. Saccharomyces / daily lily flower fermented liquid 0.01 59. Getto leaf extract 0.01 60. Purple shikibu fruit extract 0.01 61. Hibanata extract 0.01 62. Hydrolyzed soy protein 0.01 63. Tabebuia impetiginosa bark extract 0.01 64. Glucosyl hesperidin 0.01

[0062] (Manufacturing method) (a): Dissolve and mix Components 1 - 7 uniformly at 70°C. (b): Dissolve and mix Components 8 - 16 uniformly at 80°C. (c): Add (b) to (a) and emulsify at 70°C. (d): After starting the cooling of (c), sequentially add Components 17 - 64 at 45°C, and then cool to 35°C to obtain an oil-in-water type emulsified cosmetic liquid.

[0063] The oil-in-water type emulsified cosmetic liquid of Example 18 was a skin external composition excellent in whitening effect, stickiness, crystal precipitation inhibition effect, and stability over time.

Industrial applicability

[0064] The present invention can be applied to cosmetics, quasi-drugs, skin external agents, etc.

Claims

1. The following components (A) to (E); (A) Nicotinamide: 1 to 10% by mass (B) Cetyl phosphate and / or stearoyl glutamate (C) Higher alcohol that is solid at 20°C (D) Gellan gum (E) Polyhydric alcohol: 5 to 25% by mass containing An oil-in-water emulsion composition in which the blending mass ratio of component (E) to component (A) is (E) / (A) ≥ 2.

2. The oil-in-water emulsion composition according to Claim 1, further containing (F) a water-soluble whitening agent.

3. The oil-in-water emulsion composition according to Claim 2, wherein the water-soluble whitening agent of the component (F) is one or more selected from ascorbic acid derivatives and their salts, tranexamic acid, and arbutin.

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