Transparent solubilized composition

Abstract

To provide a technique that uses naturally occurring surfactant to render silicone oil, hydrocarbon oil, ester oil, or primary aliphatic alcohol transparent soluble one.SOLUTION: A transparent soluble composition contains surfactin and / or a salt thereof, alkyl glycoside, and silicone oil, hydrocarbon oil, ester oil and / or primary aliphatic alcohol.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a transparent solubilizing composition suitable for cosmetics and the like.

Background Art

[0002] In skin external preparations such as cosmetics, the solubilizer form is widely used because it has the advantage of being able to simultaneously administer lipophilic components and hydrophilic components to the skin (Patent Document 1). In addition, since the solubilizer form is transparent, it has advantages such as excellent aesthetics and providing a finished product with a transparent feeling. On the other hand, it is generally known that natural surfactants have a lower solubilizing ability compared to synthetic surfactants. Conventionally, it has been difficult to create a surfactant skeleton that transparently solubilizes silicone oil, hydrocarbon oil, ester oil, or primary aliphatic alcohol using natural surfactants.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, there is a high demand for cosmetics and the like containing natural surfactants. Therefore, an object of the present invention is to provide a technique that uses a natural surfactant and transparently solubilizes silicone oil, hydrocarbon oil, ester oil, or primary aliphatic alcohol.

Means for Solving the Problems

[0005] In order to solve the above problems, the inventors of the present invention conducted studies and found that by blending a specific surfactant of natural origin, silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol can be transparently solubilized, thus completing the present invention. Further, the present invention is also excellent in stability over time. That is, the gist of the present invention relates to the following.

[0006] [1] A transparent solubilized composition containing surfactin and / or its salt, alkyl glycoside, and silicone oil, hydrocarbon oil, ester oil and / or primary aliphatic alcohol. [2] The solubilized composition according to [1], wherein the HLB of the combination of surfactin and / or its salt and alkyl glycoside is 13 to 18. [3] The solubilized composition according to [1] or [2], wherein the pH of the solubilized composition is 6.5 or more. . [4] The solubilized composition according to any one of [1] to [3], wherein the content of surfactin and / or its salt is 0.1 to 5% by mass based on the whole composition. [5] The solubilized composition according to any one of [1] to [4], wherein the content of alkyl glycoside is 0.01 to 20% by mass based on the whole composition.

[0007] [6] The solubilized composition according to any one of [1] to [5], wherein the content of the combination of surfactin and / or its salt and alkyl glycoside is 4 times or more that of silicone oil and / or hydrocarbon oil. [5] [7] The solubilized composition according to any one of [1] to [6], wherein the content ratio (mass ratio) of surfactin and / or its salt to alkyl glycoside is 6:4 to 3:7. [8] The solubilized composition according to any one of [1] to [7], wherein the alkyl glycoside has a hydrocarbon chain having 8 to 35 carbon atoms. [9] The solubilizing composition according to any one of [1] to [8], wherein the alkyl glycoside is an alkyl glycoside represented by the following general formula (1).

[0008] [Chemical formula]

[0009] (In the formula, G represents a sugar residue, R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and n represents an integer of 1 to 4.)

[10] The solubilizing composition according to any one of [1] to [9], wherein the silicone oil is at least one selected from cyclopentasiloxane, diphenyldimethylsilicone, and diphenylsiloxyphenyltrimethicone.

[11] The solubilizing composition according to any one of [1] to

[10] , wherein the hydrocarbon oil is squalane.

[12] The solubilizing composition according to any one of [1] to

[11] , wherein the ester oil is cetyl ethylhexanoate.

[13] The solubilizing composition according to any one of [1] to

[12] , wherein the primary aliphatic alcohol is oleyl alcohol.

[14] The solubilizing composition according to any one of [1] to

[13] , further comprising essential oil and / or oily fragrance.

[15] The solubilizing composition according to any one of [1] to

[14] , wherein the solubilizing composition is a topical skin preparation.

[16] The solubilizing composition according to

[15] , wherein the topical skin preparation is a cosmetic. [Advantages of the Invention]

[0010] According to the present invention, it is possible to provide a technique for solubilizing silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol transparently using a surfactant of natural origin. That is, according to the present invention, there is provided a transparent solubilizing composition suitable for cosmetics and the like, which contains a surfactant of natural origin and contains silicone oil, hydrocarbon oil, ester oil, and / or primary aliphatic alcohol.

Best Mode for Carrying Out the Invention

[0011] The present invention will be described below. <Transparent solubilizing composition> One aspect of the present invention relates to a transparent solubilizing composition (hereinafter sometimes referred to as "the solubilizing composition of the present invention") containing surfactin and / or its salts, alkyl glycosides, and silicone oil, hydrocarbon oil, ester oil and / or primary aliphatic alcohol.

[0012] The present inventors have conducted various studies to seek a technique for transparently solubilizing silicone oil, hydrocarbon oil, ester oil, or primary aliphatic alcohol using a naturally derived surfactant. Among them, the present inventors have combined naturally derived surfactants with different HLB (Hydrophile-Lipophile Balance) values, and succeeded in creating a surfactant skeleton that can transparently solubilize silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol and has excellent stability. Based on such findings, the present invention has been completed. Moreover, since the composition in this skeleton can be solubilized even with a small total amount of surfactant, foaming and whitening during use are significantly suppressed compared to other naturally derived compositions, and it can be used comfortably. The solubilizing composition of the present invention exhibits a transparent appearance and refers to those that are so-called micelles or microemulsions.

[0013] In this specification, "transparent" means a solution that is uniform and shows no turbidity, oiliness, or separation. For example, as shown in the examples, if it is visually transparent or almost transparent after production and it can be confirmed that there is no turbidity, oiliness, separation, etc., it can be judged as a transparent composition. Also, for example, if no turbidity, oiliness, or separation is visually observed and the turbidity measured using a turbidimeter is 100 NTU or less, it may be judged as transparent.

[0014] ​≪First surfactant≫ In the solubilized composition of the present invention, as the first surfactant, it contains surfactin and its salts.

[0015] Surfactin that can be used as the first surfactant is a biosurfactant having a cyclic peptide. Surfactin is not limited as long as it exhibits the effects of the present invention, and known surfactin can be used. Surfactin may be a cyclic peptide produced by Bacillus subtilis var. natto. Examples of the cyclic peptide include 2-Deamino-3-(10-methylundecyl)-cyclo[L-Ser*-L-Glu-L-Leu-D-Leu-L-Val-L-Asp-D-Leu-L-Leu-](*indicates the optically active point). Also, those in which the hydrocarbon chain is a C9-18 alkyl group, those in which the terminal L-Leu- of the above cyclic peptide is selected from leucine, isoleucine, and valine, etc. can be mentioned.

[0016] Examples of the salt of surfactin include, but are not limited to, lithium salt, sodium salt, potassium salt, etc., and the sodium salt can preferably be used in the present invention. As the first surfactant, one or more selected from surfactin and its salts can be used in the present invention. Surfactin and its salts may be natural products extracted and purified from bacteria, etc., chemically synthesized ones, or commercially available products (manufactured by Kaneka Corporation, etc.).

[0017] ≪Second surfactant≫ In the solubilized composition of the present invention, as the second surfactant, it contains alkyl glycoside. As the second surfactant, one or more selected from alkyl glycosides can be used in the present invention.

[0018] Alkyl glycoside is a compound in which an aliphatic alcohol is bonded to a sugar by a glycosidic bond and has a hydrocarbon chain and a sugar residue. The hydrocarbon chain constituting the alkyl glycoside may be either linear or branched, and may be either saturated or unsaturated, but preferably linear or branched saturated hydrocarbons are exemplified. Also, the number of carbon atoms in the hydrocarbon chain is not particularly limited, and examples thereof include 8 to 35, 10 to 22, 12 to 20, or 12 to 16.

[0019] The sugar residue constituting the alkyl glycoside may be any of a monosaccharide, an oligosaccharide, or a polysaccharide. The degree of condensation of the sugar (i.e., the number of monosaccharides constituting the sugar residue) may be, for example, 1 to 10, 1 to 5, 1 to 3, 1 or 2, or 1 (i.e., the sugar is a monosaccharide). Specific examples of the sugar include monosaccharides such as glucose, galactose, xylose, mannose, lyxose, arabinose, and fructose; oligosaccharides or polysaccharides such as maltose, xylobiose, isomaltose, cellobiose, lactose, gentiobiose, maltotriose, isomaltotriose, cellotriose, maltotetraose, maltopentaose, maltohexaose, maltoheptaose, isomaltotetraose, isomaltopentaose, isomaltohexaose, and isomaltoheptase. Among these, monosaccharides, disaccharides, or trisaccharides are preferred. More preferably, glucose, galactose, maltose, and maltotriose are exemplified.

[0020] One embodiment of the alkyl glycoside that can be used in the present invention includes an alkyl glycoside represented by the general formula (1).

[0021]

Chemical formula

[0022] (In the formula, G represents a sugar residue, R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and n represents an integer of 1 to 4.)

[0023] The alkyl glycoside represented by the general formula (1) has a structure in which the sugar residue G and the aliphatic alcohol are condensed. The sugar residue G is the hydrophilic part in the alkyl glycoside represented by the general formula (1) and is a residue of a monosaccharide or a polysaccharide. Preferred monosaccharides include glucose, galactose, xylose, mannose, lyxose, arabinose, fructose, etc. The polysaccharide is preferably a disaccharide to a heptasaccharide, and includes maltose, xylobiose, isomaltose, cellobiose, lactose, gentiobiose, maltotriose, isomaltotriose, cellotriose, maltotetraose, maltopentaose, maltohexaose, maltoheptaose, isomaltotetraose, isomaltopentaose, isomaltohexaose, and isomaltoheptase, etc. Among these saccharides, glucose, galactose, maltose, and maltotriose are more preferred, and maltose and maltotriose are particularly preferred. Note that the sugar residue may be either the α-form or the β-form. In the general formula (1), the sugar residue G is preferably the hydroxyl group at the 1-position of the terminal sugar and is bonded (condensed) to the aliphatic alcohol.

[0024] In the general formula (1), the fatty chain is the hydrophobic part in the alkyl glycoside represented by the general formula (1). The fatty chain part may or may not have a branched chain, but preferably has a branched chain. That is, in the general formula (1), R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms but is preferably an alkyl group having 1 to 3 carbon atoms, and more preferably a methyl group.

[0025] As the alkyl glycoside represented by the general formula (1), the compound represented by the following general formula (2) is more preferred. In the general formula (2), N represents an integer from 1 to 7. R independently represents a hydrogen atom or a carbon number 1 to 3 alkyl group, and more preferably a methyl group. n represents an integer from 1 to 4, more preferably 2 or 3. Specific examples of the alkyl glycoside represented by the general formula (2) include the glycoside of maltose and hexahydrofarnesol (Mal2Far) (N = 2, n = 2, R = methyl), maltotrio se and the glycoside of hexahydrofarnesol (Mal3Far) (N = 3, n = 2, R = methyl), and the glycoside of maltotriose and dihydro phytol (Mal3Phyt) (N = 3, n = 3, R = methyl). Examples thereof include the glycoside of maltotriose and dihydro phytol (Mal3Phyt) (N = 3, n = 3, R = methyl).

[0026]

Chemical formula

[0027] The alkyl glycoside represented by the general formula (1) can be obtained by various well-known methods, such as a glycosylation method using a sugar bromide, a glycosylation method using a sugar fluoride, a glycosylation method using trichloroacetimidate, a glycosylation method using an acetylated sugar, etc. More specifically, the synthesis processes described in Patent No. 3882067, Patent No. 4817435, Patent No. 5207420, JP-A No. 2013-129660, JP-A No. 2012-17318, etc. can be mentioned.

[0028] Another aspect of the alkyl glycoside that can be used in the present invention includes alkyl glucoside. The hydrocarbon chain of the alkyl glucoside may be either linear or branched, and may be either saturated or unsaturated, but preferably a linear or branched saturated hydrocarbon is mentioned. Also, the number of carbon atoms of the hydrocarbon chain is not particularly limited, but for example, 8 to 22, or 10 to 16 can be mentioned. Although not limited, examples of the alkyl glucoside include octyl glucoside, nonyl glucoside, decyl glucoside, dodecyl glucoside, lauryl glucoside, myristyl glucoside, palmityl glucoside, stearyl glucoside, oleyl glucoside, etc.

[0029] In this embodiment, from the viewpoint of solubilization stability, the content of the first surfactant is preferably 0.1 to 5% by mass, more preferably 0.1 to 3% by mass, and still more preferably 0.3 to 2% by mass with respect to the whole composition. Further, in this embodiment, from the viewpoint of solubilization stability, the content of the second surfactant is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass, and still more preferably 0.5 to 5% by mass with respect to the whole composition.

[0030] Furthermore, from the viewpoint of solubilization stability, the total content of the first and second surfactants is preferably 0.2 to 25% by mass, more preferably 0.5 to 10% by mass, and still more preferably 1.0 to 5% by mass with respect to the whole composition. From the viewpoint of solubilization stability, 0.2% by mass or more is preferable, and from the viewpoint of formulation freedom, 25% by mass or less is preferable. In addition, in this embodiment, from the viewpoint of solubilization stability, the content of the combination of surfactin and / or its salt and alkyl glycoside is preferably 4 times or more, more preferably 6 times or more, and still more preferably 8 times or more with respect to silicone oil, hydrocarbon oil, and / or ester oil.

[0031] Moreover, in this embodiment, the mass ratio of the first surfactant to the second surfactant used is preferably 6:4 to 3:7, more preferably 5:5 to 4:6. By combining two specific surfactants in the present invention and preferably using them in such a mass ratio, a stable solubilized composition can be obtained even if an oily component is contained.

[0032] In the solubilized composition of the present invention, by combining surfactants having different HLB values such as surfactin and / or its salt and alkyl glycoside, an appropriate HLB value can be obtained, and a transparent solubilized composition can be obtained. In the solubilized composition of the present invention, the HLB of the combination of surfactin and / or its salt and alkyl glycoside is 13 or more, more than 13, 14 or more, more than 14, 14.5 or more, more than 14.5 , may be 15 or more or more than 15, may be 18 or less, less than 18, 17 or less, less than 17, 16.5 or less, less than 16.5, 16 or less, or less than 16, and these non-contradictory combinations may be used. The HLB may be, for example, 13 to 18, or 14.5 to 16. The HLB can be adjusted based on the HLB of each surfactant, the content of the surfactant described above , etc. The HLB of surfactin and / or its salt is not limited, but may be, for example, around 16 to 19, 17 to 18, or 18. The HLB of alkyl glycoside is not limited, but may be, for example, around 11 to 14, 12 to 13, or 13 . Note that the above HLB values are calculated by the following Griffin method. HLB = 20 × (molecular weight of hydrophilic group / total molecular weight)

[0033] As the pH of the solubilized composition of the present invention, for example, at 25°C, the pH may be in the range of 6.0 to 10, 6.5 to 8.0 , or 6.5 to 7.5. From the viewpoint of obtaining higher transparency and storage stability, it is preferably pH 6.5 or higher. The pH can be adjusted using a known pH adjuster.

[0034] <<Silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol>> Silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol are difficult to solubilize with natural surfactants, but the solubilized composition of the present invention can solubilize silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol transparently using natural surfactants. Therefore, silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol can be blended into the solubilized composition of the present invention as an oil agent or the like.

[0035] Examples of silicone oils include, but are not limited to, chain polysiloxanes such as dimethylpolysiloxane (cosmetic designation: dimethicone), methylphenylpolysiloxane (cosmetic designations: diphenyldimethylsilicone, diphenylsiloxy phenyltrimethicone, etc.), cyclic polysiloxanes such as octamethylcyclotetrasiloxane (cosmetic designation: cyclotetrasiloxane), decamethylcyclopentasiloxane (cosmetic designation: cyclopentasiloxane), dodecamethylcyclohexasiloxane (cosmetic designation: cyclohexasiloxane), modified polysiloxanes such as amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, and fluorine-modified polysiloxane. Preferred are chain polysiloxanes and cyclic polysiloxanes, and more preferred are cyclopentasiloxane, diphenyldimethylsilicone, and diphenylsiloxy phenyltrimethicone. The silicone oil can be used alone or in combination of two or more. The silicone oil can be one produced by a conventional method or a commercially available product.

[0036] Examples of hydrocarbon oils include, but are not limited to, squalane, liquid paraffin, pristane, ozokerite, paraffin, ceresin, petrolatum, microcrystalline wax, and other hydrocarbon oils. Preferred is squalane. The hydrocarbon oil can be used alone or in combination of two or more. The hydrocarbon oil can be one produced by a conventional method or a commercially available product.

[0037] ​Examples of the ester oil include, but are not limited to, cetyl isooctanoate, isopropyl myristate, hexyl decyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, cetyl 2-ethylhexanoate (cosmetic designation: cetyl ethylhexanoate), ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, etc. Preferably, it is cetyl ethylhexanoate. The ester oil can be used alone or in combination of two or more. The ester oil can be one produced by a conventional method or a commercially available one.

[0038] Examples of the primary aliphatic alcohol include, but are not limited to, primary aliphatic alcohols having 6 to 22 carbon atoms, preferably 8 to 18 carbon atoms. Specifically, saturated straight-chain alcohols such as 1-hexanol, 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol, 1-dodecanol, 1-tetradecanol, 1-hexadecanol, 1-octadecanol, 1-eicosanol, 1-docosanol; saturated alicyclic alcohols such as cyclohexanemethanol, cyclohexylethyl alcohol; unsaturated alcohols such as oleyl alcohol, citronellol, etc. Preferably, it is oleyl alcohol. The primary aliphatic alcohol can be used alone or in combination of two or more. The primary aliphatic alcohol can be one produced by a conventional method or a commercially available one.

[0039] The content of the silicone oil, hydrocarbon oil, ester oil, and primary aliphatic alcohol, as the total amount alone or in combination, is preferably 0.01 to 5 mass %, more preferably 0.05 to 1 mass%, still more preferably 0.1 to 0.5 mass%. From the viewpoint of dissolution stability, 5% by mass or less is preferable, and from the viewpoint of the effects in the composition, 0.01% by mass or more is preferable.

[0040] ≪Essential oil and oily fragrance≫ Another aspect of the present invention relates to a transparent solubilized composition further containing an essential oil and / or an oily fragrance. Generally, essential oils and oily fragrances are known to be difficult to solubilize, but the solubilized composition of the present invention can solubilize essential oils and oily fragrances transparently using a surfactant derived from nature. Therefore, essential oils and oily fragrances can be blended into the solubilized composition of the present invention as active ingredients, fragrances, etc.

[0041] Here, the essential oil is a mixture of water-insoluble to poorly soluble organic compounds contained in plants, generally contains volatile organic compounds, and has an aromatic property depending on the raw material. The essential oil used in the present invention can be one produced by a conventional method or a commercially available one. In addition, the collection site of the essential oil in the present invention is not particularly limited, and examples include flowers, branches, leaves, roots, fruits, buds, etc., and the whole herb can also be used. Also, the extraction method of the essential oil in the present invention is not particularly limited, and examples include steam distillation method, solvent extraction method, pressing method, adsorption / absorption method, leaching method, a method of collecting the exuded liquid by damaging the plant, etc., and the steam distillation method is preferable.

[0042] The oily fragrance is a fragrance showing oil solubility, and can be used regardless of whether it is synthetic or natural. Also, those produced by a conventional method or commercially available ones can be used.

[0043] As essential oils and oily fragrances, but not limited to, for example, acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoeugenol, isobutyl quinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galaxolide, carvacrol, L-carboxylic, camphor, canon, carrot seed oil, clove oil, methyl caffeate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethyl benzyl carbinyl acetate, styrallyl acetate, cedryl acetate, terpinyl acetate, p-t-butyl cyclohexyl acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronellol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damasconen, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, triplal, nerol, nonanal, 2,6-Nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, ptycholen oil, hexyl cinnamaldehyde, cis-3-hexenol, Peru balsam, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrrh resinoid, musk ketone, methyl nonyl acetaldehyde, γ-methyl ionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lilial, lilyal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, etc. can be exemplified. Essential oils and oily fragrances can be used alone or in combination of two or more kinds.,

[0044] The content of the essential oil and the oily fragrance, as the total amount alone or in combination, is preferably 0.001 to 5% by mass, more preferably 0.01 to 1% by mass, still more preferably 0.1 to 0.5% by mass with respect to the whole composition. From the viewpoint of solubilization stability, 5% by mass or less is preferable, and from the viewpoint of the effect in the composition 0.001% by mass or more is preferable.,

[0045] ≪Other Components≫ In addition, the solubilized composition of the present invention can contain other optional components as long as the effects thereof are not impaired., The optional components are not particularly limited as long as they can be usually formulated in topical skin preparations, and examples include oils, solvents, polyhydric alcohols, surfactants other than essential components (cationic surfactants, anionic surfactants, nonionic surfactants, silicone-based surfactants, etc.), various active ingredients, humectants, pH adjusters, thickeners, preservatives, powders, organically modified clay minerals, antibacterial agents, ultraviolet light scattering / absorbing agents, and the like. As the antibacterial agents, natural antibacterial substances such as caprylyl glycol, glyceryl caprylate, ethylhexylglycerin, and caprylic hydroxamic acid are preferably mentioned. The optional components can be used in the present invention alone or in combination of two or more kinds. The active ingredients include moisturizing ingredients, whitening ingredients, wrinkle-improving ingredients, anti-inflammatory ingredients, extracts derived from animals and plants, etc., and may contain only one kind or two or more kinds.

[0046] The optional components include, but are not limited to, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil , oils and waxes such as coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil, hydrogenated oil, beeswax, hydrogenated castor oil, candelilla wax, carnauba wax, spermaceti wax, lanolin, reduced lanolin, hard lanolin, jojoba wax, etc.; oil agents such as higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, isopalmitic acid, stearic acid, behenic acid, undecylenic acid, etc.; polyhydric alcohols such as polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, etc.; moisturizing components such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, etc.; powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc., which may be surface-treated; inorganic pigments such as red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, navy blue, titanium oxide, zinc oxide, etc., which may be surface-treated; pearl agents such as mica titanium, fish scale foil, bismuth oxychloride, etc., which may be surface-treated; organic dyes such as Red No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc., which may be lake-colored; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, etc.; ultraviolet absorbers such as para-aminobenzoic acid-based ultraviolet absorbers, anthranilic acid-based ultraviolet absorbers, salicylic acid-based ultraviolet absorbers, cinnamic acid-based ultraviolet absorbers, benzophenone-based ultraviolet absorbers, sugar-based ultraviolet absorbers, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, 4-methoxy-4'-t-butyldibenzoylmethane, etc.; aqueous media such as water; lower alcohols such as ethanol, isopropanol, etc. can be preferably exemplified.

[0047] In addition, these optional components can be added at any step in the present invention or before and after it. The manufacturing method of the solubilized composition of the present invention can be manufactured based on the conventional solubilization method, except for having the above essential components.

[0048] ≪Skin external preparations and cosmetics≫ The skin external preparation of the present invention contains the solubilized composition of the present invention and is suitable for use as, for example, cosmetics including pharmaceuticals and quasi-drugs. Cosmetics are particularly preferred. The dosage form is not particularly limited as long as it is a solubilized dosage form, and for example, lotions, essences, etc. are preferably exemplified. Except for using the solubilized composition of the present invention, the production of skin external preparations, pharmaceuticals, and cosmetics including quasi-drugs can be carried out using conventionally known production methods.

Examples

[0049] Hereinafter, the present invention will be specifically described by way of examples, but these are merely illustrative of the present invention and the scope of the present invention is not limited thereto.

[0050] Solubilized compositions of the examples and comparative examples were prepared according to the formulations shown in Table 1. Specifically, components other than silicone oil, hydrocarbon oil, ester oil, primary aliphatic alcohol, and essential oil were heated to 80°C for homogenization, and after adding silicone oil, hydrocarbon oil, ester oil, primary aliphatic alcohol, and essential oil, it was cooled while stirring to 30°C.

[0051] For the solubilized compositions of the examples and comparative examples, a visual confirmation test of the dissolution state was conducted. The criteria for judgment are as follows. (Transparency) ◎: In a transparent state, 〇: Almost in a transparent state, △: Slight turbidity or separation is observed, ×: Turbidity or separation is observed. (Oily) 〇: No oiliness is observed after 24 hours at 0°C after production, ×: Oiliness is observed. Also, the pH was measured with a pH meter.

[0052]

Table 1

[0053] As natural surfactants, surfactin and Mal2 which is an alkyl glycoside The solubilized compositions of Examples 1 to 6 containing Far were solubilized compositions with excellent transparency. Also no oil separation was observed 24 hours after production, and they also had excellent stability over time. Also, the solubilized composition of Example 7 containing surfactin and decyl glucoside which is an alkyl glycoside was also a solubilized composition with excellent transparency. Also, no oil separation was observed 24 hours after production, and it also had excellent stability over time. On the other hand, Comparative Examples 1, 3 , 5, 7, 9 which do not contain surfactin and contain Mal2Far and decyl glucoside, although their HLB was in an appropriate range, had insufficient transparency and stability over time . The compositions of Comparative Examples 2, 4, 6, 8, 10 containing surfactin as a natural surfactant and polyglyceryl monolaurate or sucrose fatty acid ester as a synthetic surfactant had insufficient transparency and stability over time. Therefore, it can be seen that the solubilized composition of the present invention is a composition using silicone oil, hydrocarbon oil, ester oil, and natural surfactants, and is a solubilized composition excellent in transparency and stability over time.

Industrial Applicability

[0054] The present invention can be applied to cosmetics, quasi-drugs, pharmaceuticals, etc.

Claims

1. Surfactin and / or its salt, alkyl glycoside, and silicone oil, hydrocarbon oil, ester oil and / or primary aliphatic alcohol, containing a transparent solubilizing composition in which the content ratio (mass ratio) of surfactin and / or its salt to alkyl glycoside is 6:4 to 3:

7.

2. The HLB of the combination of surfactin and / or its salt and alkyl glycoside is 13 to 18, and the solubilizing composition according to claim 1.

3. The solubilizing composition according to claim 1 or 2, wherein the pH of the solubilizing composition is 6.5 or more.

4. The solubilizing composition according to any one of claims 1 to 3, wherein the content of surfactin and / or its salt is 0.1 to 5% by mass based on the whole composition.

5. The solubilizing composition according to any one of claims 1 to 4, wherein the content of alkyl glycoside is 0.01 to 20% by mass based on the whole composition.

6. The content of the combination of surfactin and / or its salt and alkyl glycoside is 4 times or more that of silicone oil and / or hydrocarbon oil, and any one of claims 1 to 5 The solubilizing composition according to one item.

7. The solubilizing composition according to any one of claims 1 to 6, wherein the alkyl glycoside has a hydrocarbon chain having 8 to 35 carbon atoms One item described.

8. The solubilizing composition according to any one of claims 1 to 7, wherein the alkyl glycoside is an alkyl glycoside represented by the following general formula (1). 【Chemical 1】 (In the formula, G represents a sugar residue, R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and n represents an integer of 1 to 4.)

9. The solubilizing composition according to any one of claims 1 to 8, wherein the silicone oil is at least one selected from cyclopentasiloxane, diphenyldimethylsilicone and diphenylsiloxyphenyltrimethicone.

10. The solubilizing composition according to any one of claims 1 to 9, wherein the hydrocarbon oil is squalane.

11. The solubilizing composition according to any one of claims 1 to 10, wherein the ester oil is cetyl ethylhexanoate.

12. The solubilizing composition according to any one of claims 1 to 11, wherein the primary aliphatic alcohol is oleyl alcohol.

13. Furthermore, the solubilizing composition according to any one of claims 1 to 12, which contains essential oil and / or oily fragrance.

14. The solubilized composition according to any one of claims 1 to 13, wherein the solubilized composition is a topical skin preparation.

15. The solubilized composition according to claim 14, wherein the topical skin preparation is a cosmetic.

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