Medical materials

Abstract

To provide a medical material achieving, for the atrial septal defect, minimally invasive treatment with little possibility of failure in a post-discharge period.SOLUTION: A medical material includes a proximal joint 412 formed by including one substantially central part and two cylindrical parts (a first cylindrical part and a second cylindrical part) of a bioabsorbable-material reticulated tissue and joined to a first end 112, and a distal joint part 422 joined to a second end 122 and threadedly engaged with a delivery cable. The proximal joint part 412 and the distal joint part 422 can reversibly or irreversibly achieve a lock state of keeping an integrated state thereof, and an unlocked state of not keeping the integrated state. When the distal joint part 422 is inserted into the proximal joint part 412, an engagement portion 422C of the distal joint part 422 is engaged with an engagement object portion 412C of the proximal joint part 412, so that the medical material transitions from the unlocked state to the lock state.SELECTED DRAWING: Figure 11

Description

[Technical field]

[0001] The present invention relates to a medical material for repairing holes formed in living tissue, and more particularly to a medical material that is set on a catheter, fed through a blood vessel to the treatment site, and left in the living body. [Background technology]

[0002] The human heart is divided into left and right chambers by a tissue called the septum, and each chamber has an atrium and a ventricle, making it a two-atrium, two-ventricle structure: the right atrium, the right ventricle, the left atrium, and the left ventricle. In a heart with this structure, there is a disease called atrial septal defect (ASD), in which a hole is congenitally formed in the atrial septum that separates the right atrium and the left atrium due to a developmental disorder during fetal development.

[0003] There are two methods for treating this atrial septal defect: one is a surgical procedure that involves cutting the chest, and the other is catheter treatment that uses an occluder without cutting the chest. In surgical procedures (patch surgery), a heart-lung machine is used, the chest is opened, and the hole is closed with a patch. In catheter therapy, a closure plug is placed on a catheter, which is then inserted into a blood vessel and advanced to the desired location (the location of the hole), after which the closure plug is released and left in the body. In this catheter therapy, a small, folded tool (device) called a closure plug is advanced from a vein at the base of the leg (femoral vein) to the location of the hole in the atrial septum, closing the hole, without opening the chest. The advantage of this catheter therapy is that it can be performed with a very small incision (a few millimeters) in the skin from an inconspicuous location such as the groin (groin), without the need for open-chest surgery, which requires general anesthesia.

[0004] JP 2021-053267 A (Patent Document 1) discloses a medical material that is suitable for use in such catheter treatments, enabling minimally invasive catheter treatments that can be released and placed at treatment sites inside the body with easy and reliable operation without a complex structure, and which has almost no risk of long-term malfunctions even if it remains in the body.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] In the case of patch surgery, cardiopulmonary bypass is used, and there is a problem that the hospitalization period is long because of the high invasiveness. In the case of catheter treatment, cardiopulmonary bypass is not used, and the invasiveness is low, so the hospitalization period is short, which is preferable. The medical material disclosed in Patent Document 1 is a device developed and filed by the applicant of the present application and has received favorable reviews. Here, the medical material disclosed in Patent Document 1 is formed by two cylindrical bodies (a first cylindrical part and a second cylindrical part) of a mesh-like tissue, and includes a hand-held joint part joined to the first end part and a tip joint part joined to the second end part and screwed to a delivery cable, and a lock for maintaining a state in which the hand-held joint part and the tip joint part are integrated, and an unlock for not maintaining the integrated state can be selectively realized. Regarding the workability of the transition from this unlocked state to the locked state (and vice versa), there was room for improvement.

[0007] The present invention has been developed in view of the medical material disclosed in Patent Document 1 disclosed as the prior art, and the object thereof is to provide a minimally invasive catheter treatment that can be released and retained at a treatment site in a living body, which is possible with an easy and reliable operation without a complicated structure and has almost no possibility of problems in the long term even if it remains in the body.

Means for Solving the Problems

[0008] To achieve the above object, the medical material according to the present invention takes the following technical means. That is, the medical material according to the present invention is a medical material formed by a cylindrical body including one substantially central portion and two cylindrical portions of a mesh-like structure using a bioabsorbable wire. The two cylindrical portions include a first cylindrical portion and a second cylindrical portion sandwiching the substantially central portion, and have a shape in which the cylindrical diameter of the substantially central portion is smaller than the cylindrical diameters of other portions. The first cylindrical portion on the first end side in the longitudinal direction of the cylindrical body centered on the substantially central portion and the second cylindrical portion on the second end side which is the other end are formed. When the first end and the second end are separated with the substantially central portion as the center and the cylindrical diameter of the other portion is reduced and the medical material is stored in the catheter, the second end side becomes the tip side of the catheter. The medical material includes a proximal joint portion joined to the mesh-like structure at the first end and a distal joint portion joined to the mesh-like structure at the second end. The proximal joint portion has a substantially hollow cylindrical shape, the distal joint portion has a substantially cylindrical shape, and the substantially cylindrical shape of the distal joint portion is formed so as to be insertable into the substantially hollow cylinder of the proximal joint portion. The proximal joint portion and the distal joint portion can reversibly or irreversibly realize a lock for maintaining an integrated state and an unlock for not maintaining the integrated state. The inner diameter of the proximal joint portion is larger than the outer diameter of a delivery cable inserted into the catheter. The distal joint portion can selectively realize a joined state joined to the tip of the delivery cable and a non-joined state not joined. A delivery cable in which the distal joint portion and the tip of the delivery cable are joined is formed so as to be inserted through the hollow cylinder of the proximal joint portion from the second end side through the substantially central portion and passed to the outside of the medical material from the first end side. The distal joint portion includes an outer diameter portion larger than the outer diameter of the delivery cable and smaller than the inner diameter of the proximal joint portion, and an engaging portion larger than the outer diameter of the outer diameter portion. The proximal joint portion includes an inner diameter portion matching the outer diameter portion and an engaged portion larger than the inner diameter of the inner diameter portion and matching the engaging portion. When the distal joint portion is inserted into the proximal joint portion, the engaging portion of the distal joint portion engages with the engaged portion of the proximal joint portion, thereby transitioning from the unlocked state to the locked state.

[0009] Preferably, when the engaging portion is inserted into the inner diameter portion, the proximal joint portion is configured to have a deployability such that the inner diameter on the distal joint portion side expands, and when the engaging portion engages with the engaged portion, the expansion is eliminated. More preferably, the proximal joint portion having a substantially hollow cylindrical shape is configured to realize the deployability by including one or more grooves that communicate the outer surface and the inner surface of the substantially hollow cylinder from an end surface on the distal joint portion side to a predetermined position that does not reach the end surface on the first end portion side.

[0010] More preferably, the predetermined position can be configured to be a position on the first end portion side that is closer to the proximal side than the engaged portion. More preferably, the engaging portion and / or the engaged portion are configured to have a shape in which the resistance in the relative movement between the proximal joint portion and the distal joint portion is greater when transitioning from lock to unlock to separate the distal joint portion from the proximal joint portion than when transitioning from unlock to lock when the distal joint portion is inserted into the proximal joint portion.

[0011] More preferably, the shape can be configured such that the first end portion side, which is on the proximal side, is smoother than the second end portion side, which is on the distal side. More preferably, the first end portion side, which is on the proximal side, can be configured to have a shape including a curved surface shape, and the second end portion side, which is on the distal side, can be configured to have a shape including a flat surface shape.

Advantages of the Invention

[0012] According to the medical material of the present invention, minimally invasive catheter treatment that can be released and retained at a treatment site in the living body can be performed easily and reliably without a complicated structure. Further, according to the medical material of the present invention, even if it remains in the body, there is almost no possibility of problems in the long term.

Brief Description of the Drawings

[0013]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Mode for Carrying Out the Invention

[0014] Hereinafter, the medical material according to the present invention will be described in detail with reference to the drawings. In the following, as an example of the medical material according to the present invention, a closure plug (sometimes referred to as medical material 100) used in catheter treatment will be described. However, the medical material according to the present invention is also suitable for closing other openings or passages, such as other openings of the heart such as ventricular septal defect and patent ductus arteriosus, and openings or passages of other parts of the living body such as arteriovenous fistula (for example, the stomach). Therefore, the closure plug (medical material 100) according to the embodiment of the present invention is not limited to use for closing the hole of atrial septal defect.

[0015] Furthermore, in the following embodiments, the mesh-like structure of the medical material 100, which is an example of the medical material according to the present invention, will be described as being woven from bioabsorbable (synonymous with biodegradable and bioresorbable) fibers (an example of a wire). However, the present invention is not limited thereto. The medical material according to the present invention may be a closure plug (medical material 100) capable of catheter treatment for closing a hole formed in a living body, and its mesh-like structure and material are not limited. For example, the material may be woven from a wire other than bioabsorbable fibers. Such a wire preferably has a certain degree of hardness in order to provide the shape retention of the closure plug (medical material 100).

[0016] Fig. 1 shows an overall view of the medical material 100 according to the present embodiment (the distance between the first end portion 112 and the second end portion 122 is in a close state), Fig. 2 shows another overall view of the medical material 100 (the distance between the first end portion 112 and the second end portion 122 is in an intermediate state), Fig. 3 shows yet another overall view of the medical material 100 (the entire medical material 100 is housed in the catheter 300 and the distance between the first end portion 112 and the second end portion 122 is in a separated state), and Fig. 4 shows yet another overall view of the medical material 100 (the second cylindrical portion 120 is extended out of the catheter 300 and the first cylindrical portion 110 is housed in the catheter 300). Note that, regarding the housing relationship of the medical material 100 in the catheter 300, Fig. 3 shows a state where the entire medical material 100 is housed in the catheter 300, and Fig. 4 shows a state where half of the medical material 100 (the first cylindrical portion 110 side) is housed in the catheter 300.

[0017] In terms of temporal transition, when the medical material 100, which is entirely housed in the interior (the space formed by the inner wall 310) of the catheter 300 shown in Fig. 3, is taken out from the opening 320 of the catheter 300 in the direction of arrow Y with the second cylindrical portion 120, the state shown in Fig. 4 is obtained, and when the first cylindrical portion 110 is further taken out in the direction of arrow Y, the state shown in Fig. 1 is obtained. Here, the state of the medical material 100 shown in Fig. 2 is a virtual state where the distance between the first end portion 112 and the second end portion 122 is in an intermediate state. Fig. 5(A) shows a partial side view of the medical material 100, and Fig. 5(B) shows a cross-sectional view taken along the line A-A of Fig. 2 and Fig. 5(A). Note that Fig. 5(B) is a cross-sectional view of the medical material 100 (more specifically, the second cylindrical portion 120), but the cross-section of the cable body 510 of the delivery cable 500 is shown, and the stitches of the bioabsorbable fiber 150 that can be visually recognized from the direction of arrow A used to indicate the direction of the cross-sectional view are not shown. Figs. 10 and 11 are diagrams for explaining the tip joint portion 422 provided at the tip-side end portion (the second end portion 122) of the medical material 100, the hand-side joint portion 412 provided at the hand-side end portion (the first end portion 112), and the delivery cable 500 joined to the tip joint portion 422 by screwing. Note that "hand" and "root" have the same meaning.

[0018] Here, the tip joint portion 422 can selectively achieve a joint state in which it is joined to the tip of the cable body 510 of the delivery cable 500 and a non-joint state in which it is not joined. For example, a male screw is provided at the tip of the cable body 510 of the delivery cable 500, and a female screw that is screwed onto the male screw is provided on the substantially cylindrical tip joint portion 422 (the screw is not shown in Fig. 10(A)). By screwing these female and male screws together, the joint state can be achieved, and by releasing the screwing, the non-joint state can be achieved.

[0019] As shown in these Figs. 1 to 5, Fig. 10, and Fig. 11, this medical material 100 is roughly formed by a cylindrical body including one substantially central portion of a mesh-like structure using a wire and two cylindrical portions, and has a shape in which the cylindrical diameter of the substantially central portion 130 of this cylindrical body is smaller than the cylindrical diameters of other portions. With the substantially central portion 130 as the center, a first cylindrical portion 110 on the first end portion 112 side in the longitudinal direction of the cylindrical body in the medical material 100 and a second cylindrical portion 120 on the other end portion (second end portion 122) side are formed.

[0020] What is characteristic is that when the first end portion 112 and the second end portion 122 are separated with the substantially central portion 130 as the center and the tube diameter of the other portion is reduced and the medical material 100 is stored in the catheter 300 (the state shown in FIG. 3), the second end portion 122 side becomes the tip side of the catheter 300. In this case, this medical material 100 includes a proximal joint portion 412 joined to the mesh-like tissue at the first end portion 112 and a distal joint portion 422 joined to the mesh-like tissue at the second end portion 122. Although not limited, the bioabsorbable fibers 150 forming the first tube portion 110 are passed through the hole portion 412H provided in the proximal joint portion 412, and the bioabsorbable fibers 150 passed through the hole portion 412H in this way are joined to the bioabsorbable fibers 150 not passed through the hole portion 412H, etc., so that the proximal joint portion 412 is joined to the mesh-like tissue at the first end portion 112. The bioabsorbable fibers 150 forming the second tube portion 120 are passed through the hole portion 422H provided in the distal joint portion 422, and the bioabsorbable fibers 150 passed through the hole portion 422H in this way are joined to the bioabsorbable fibers 150 not passed through the hole portion 422H, etc., so that the distal joint portion 422 is joined to the mesh-like tissue at the second end portion 122. The number of the hole portion 412H and the hole portion 422H is not limited, but four are provided respectively.

[0021] Here, the distal joint portion 422 is configured to be able to selectively realize a joined state joined to the tip of the delivery cable 500 and a non-joined state not joined. The delivery cable 500 with the distal joint portion 422 joined to the tip of the delivery cable 500 is inserted into the hollow tube of the proximal joint portion 412 from the second end portion 122 side via the substantially central portion 130, and can be passed to the outside of the medical material 100 from the first end portion 112 side (for example, a hole through which the cable body 510 of the delivery cable 500 passes is formed in the first end portion 112). Regarding the characteristic configuration of this medical material 100, it will be described in detail below mainly with reference to FIGS. 10 and 11.

[0022] As shown in these figures, the proximal joint portion 412 has a substantially hollow cylindrical shape, the distal joint portion 422 has a substantially cylindrical shape, and the substantially cylindrical shape of the distal joint portion 422 is formed to be insertable into the substantially hollow cylinder of the proximal joint portion 412. In this medical material 100, the proximal joint portion 412 and the distal joint portion 422 can reversibly or irreversibly realize a lock for maintaining the integrated state and an unlock for not maintaining the integrated state. In order to reversibly or irreversibly realize such a lock / unlock, the following configurations are provided for the proximal joint portion 412 and the distal joint portion 422. The inner diameter of the proximal joint portion 412 having a substantially hollow cylindrical shape is larger than the outer diameter of the delivery cable 500 inserted into the catheter 300. A delivery cable with the distal joint portion and the distal end of the delivery cable joined is formed to be insertable through the hollow cylinder of the proximal joint portion from the second end side through the substantially central portion and passed to the outside of the medical material from the first end side. The distal joint portion 422 having a substantially cylindrical shape includes an outer diameter portion 422A that is larger than the outer diameter of the delivery cable 500 and smaller than the inner diameter of the proximal joint portion 412, and an engaging portion 422C that is larger than the outer diameter of the outer diameter portion 422A. Further, the proximal joint portion 412 is formed to include an inner diameter portion 412A that matches the outer diameter portion 422A, and an engaged portion 412C that is larger than the inner diameter of the inner diameter portion 412A and matches the engaging portion 422C. Here, the fact that the inner diameter portion 412A in the proximal joint portion 412 matches the outer diameter portion 422A means that at least the inner diameter of the inner diameter portion 412A is larger than the outer diameter of the outer diameter portion 422A, and the outer diameter portion 422A of the distal joint portion 422 can be inserted into the inner diameter portion 412A of the proximal joint portion 412. Also, the fact that the engaged portion 412C in the proximal joint portion 412 matches the engaging portion 422C means that the outer shape (concave shape) of the engaged portion 412C is at least the same as or slightly larger than the outer shape (convex shape) of the engaging portion 422C, and the engaging portion 422C of the distal joint portion 422 can engage (catch and stop) with the engaged portion 412C of the proximal joint portion 412.When the distal joint portion 422 is inserted into the proximal joint portion 412, the engaging portion 422C of the distal joint portion 422 engages with the engaged portion 412C of the proximal joint portion 412, causing the medical material 100 to transition from the unlocked state to the locked state.

[0023] Here, the proximal joint portion 412 preferably has the property of expandability such that when the engaging portion 422C is inserted into the inner diameter portion 412A, the inner diameter on the side of the distal joint portion 422 expands, and when the engaging portion 422C engages with the engaged portion 412C, the expansion of the inner diameter is eliminated. Here, although this is an example, the proximal joint portion 412 having a substantially hollow cylindrical shape can have the following configuration. For example, in the proximal joint portion 412, from the end face on the side of the distal joint portion 422 to a predetermined position that does not reach the end face on the side of the first end portion 112 (proximal side), there is a groove 412B that communicates the outer surface and the inner surface of the substantially hollow cylinder, and by providing one or more grooves 412B along the longitudinal direction of the delivery cable 500, this expandability can be realized. Here, four grooves 412B are provided symmetrically with respect to a line and point in a plane perpendicular to the longitudinal direction of the delivery cable 500. Also, this predetermined position is preferably a position on the side of the first end portion 112 that is closer to the proximal side than the engaged portion 412C in terms of achieving good expandability.

[0024] Further, the engaging portion 422C of the distal end joint portion 422 and / or the engaged portion 412C of the proximal end joint portion 412 (here, it may be either the engaging portion 422C of the distal end joint portion 422 and the engaged portion 412C of the proximal end joint portion 412) has a shape with a greater resistance to relative movement between the proximal end joint portion 412 and the distal end joint portion 422 when transitioning from unlock to lock when the distal end joint portion 422 is inserted into the proximal end joint portion 412 than when transitioning from lock to unlock to disengage the distal end joint portion 422 from the proximal end joint portion 412. This is preferable in terms of making it easier to maintain the locked state. To change the resistance in such relative movement, the following configuration can be provided as this shape. For example, the shape of the engaging portion 422C of the distal end joint portion 422 and / or the engaged portion 412C of the proximal end joint portion 412 is such that the first end portion 112 side on the proximal end side is smoother than the second end portion 122 side on the distal end side. More specifically, as shown in FIGS. 10 and 11, the first end portion 112 side on the proximal end side includes a curved surface shape 412C1 and a curved surface shape 422C1, and the second end portion 122 side on the distal end side includes a flat surface shape 412C2 and a flat surface shape 422C2.

[0025] These features will be described collectively below. In the medical material 100 according to the present embodiment, the proximal end joint portion 412 and the distal end joint portion 422 are configured to be able to reversibly or irreversibly realize a lock for maintaining an integrated state and an unlock for not maintaining an integrated state. The mechanism of the lock / unlock mechanism in the medical material 100 is realized by the distal end joint portion 422 provided on the left atrium side (distal end side, second end portion 122 side) of the knitted tube body and the proximal end joint portion 412 provided on the right atrium side (proximal end side, first end portion 112 side). When the distal end joint portion 422 is inserted into the proximal end joint portion 412, the engaging portion 422C of the distal end joint portion 422 engages with the engaged portion 412C of the proximal end joint portion 412, causing the medical material 100 to transition from the unlocked state to the locked state.

[0026] More specifically, (the outer diameter of the delivery cable 500 <) the outer diameter of the outer diameter portion 422A of the tip joint portion 422 < the inner diameter of the inner diameter portion 412A of the proximal joint portion 412 < the outer diameter of the engaging portion 422C of the tip joint portion 422 < the inner diameter of the engaged portion 412C of the proximal joint portion 412 (< the outer diameter of the proximal joint portion 412 < the inner diameter of the catheter 300) is satisfied. First, as shown in FIG. 10(A), the outer diameter portion 422A of the tip joint portion 422 begins to enter the inner diameter portion 412A of the proximal joint portion 412 (the intrusion direction is the direction of arrow X(2)), and the state shown in FIG. 10(B) is reached. From the state shown in FIG. 10(B), when the outer diameter portion 422A of the tip joint portion 422 further enters the inner diameter portion 412A of the proximal joint portion 412, that is, when the engaging portion 422C of the tip joint portion 422 begins to enter the inner diameter portion 412A of the proximal joint portion 412, the width of the groove 412B provided in the proximal joint portion 412 expands, and due to the expandability, the inner diameter portion 412A of the proximal joint portion 412 is deformed so as to increase, and the inner diameter of the inner diameter portion 412A expands (the inner diameter of the inner diameter portion 412A of the proximal joint portion 412 ≒ the outer diameter of the engaging portion 422C of the tip joint portion 422). In addition, even when the inner diameter of the inner diameter portion 412A expands in this way, in order that the proximal joint portion 412 is not broken, for example, a material having flexibility is preferably adopted.

[0027] When the outer diameter portion 422A of the tip joint portion 422 further enters the inner diameter portion 412A of the proximal joint portion 412, the engaging portion 422C of the tip joint portion 422 engages with the engaged portion 412C of the proximal joint portion 412, and at the same time, the expansion of the inner diameter of the inner diameter portion 412A is eliminated, and the medical material 100 transitions from the unlocked state to the locked state. Furthermore, although not limited thereto, when the first end portion 112 side, which is the hand side, includes the curved surface shapes 412C1 and 422C1 (both hemispherical (dome-shaped)), and the second end portion 122 side, which is the tip side, is formed to include the planar shapes 412C2 and 422C2, once the state transitions from the unlocked state to the locked state, it is preferable in that the medical material 100 set in the hole is less likely to accidentally fall off because it is difficult to transition from the locked state to the unlocked state. Note that it is not essential for the shapes of the engaging portion 422C and the engaged portion 412C to be hemispherical, and it is preferable in that the locked state / unlocked state can be reversibly operated by making them spherical or the like.

[0028] In addition, the material of the hand joint portion 412 and the tip joint portion 422 is not particularly limited as long as the above-described configuration or function can be realized, and it may be made of metal, resin, a material having bioabsorbability, or any other material. Here, the lengths in the longitudinal direction of the illustrated tip joint portion 422 and the hand joint portion 412 (the same as the longitudinal direction of the cable body 510 of the delivery cable 500) are merely examples, and are not limited as long as the unlocked state and the locked state can be realized reversibly or irreversibly, and their lengths are set as appropriate.

[0029] Furthermore, in the state shown in FIG. 1, the length of the substantially central portion 130 (which is also the distance between the first end portion 112 and the second end portion 122) is changed according to the thickness of the atrial septum, which varies from individual to individual. Further, the lengths in the longitudinal direction of the tip joint portion 422 and the hand joint portion 412 are set such that when the thickness of the atrial septum is thin, the tip joint portion 422 and the hand joint portion 412 are closer to each other and can be locked, and when the thickness of the atrial septum is thick, the tip joint portion 422 and the hand joint portion 412 are farther apart and can be locked. This is also conceivable.

[0030] In the state where the entire medical material 100, with the tip of the delivery cable 500 joined to the second end portion 122 by the tip joint portion 422, is housed in the catheter 300, the delivery cable 500 is operated so that the medical material 100 advances in the direction of the opening of the catheter 300. As the first cylindrical portion 110 following the second cylindrical portion 120 extends out of the catheter 300 from the tip of the catheter 300, the first end portion 112 and the second end portion 122 approach each other with the substantially central portion 130 as the center. Further, the delivery cable 500 is operated to integrate the handpiece joint portion 412 and the tip joint portion 422 as described above and lock them to maintain the state, and the diameter of the other part of the cylinder is maintained in an expanded state corresponding to the size of the hole closed by the medical material 100. Further, the delivery cable 500 is operated so that the tip joint portion 422 and the tip of the delivery cable 500 are shifted from the joined state to the non-joined state, and the catheter 300 with the delivery cable 500 inserted therein is formed to be detachable from the portion with the hole together with the delivery cable 500.

[0031] These procedures can be described as usage modes with reference to FIGS. 6 to 9, for example, when this medical material 100 is used for catheter treatment of atrial septal defect. However, the usage mode of this medical material 100 described with reference to FIGS. 6 to 9 of the present application is the same as the description of FIGS. 6 to 9 in Japanese Patent Application Laid-Open No. 2021-053267 (Patent Document 1 in the present application), International Publication No. 2016-174972 (U.S. Patent Application Publication No. 2018 / 0103956A1), and International Publication No. 2020-012728 (U.S. Patent Application Publication No. 2021 / 0169497A1) filed by the applicant of the present application, except that the structure of the tip joint portion 422 and the handpiece joint portion 412 and the locking / unlocking by those structures can be realized reversibly or irreversibly. Therefore, the detailed description here will not be repeated.

[0032] Here, the state of the medical material 100 in FIGS. 6 and 7 is the state of FIG. 3 (unlocked state), the state of the medical material 100 in FIG. 8 is the state of FIG. 4 (unlocked state), and the state of the medical material 100 in FIG. 9 is the state of FIG. 1 (locked state). As described above, according to the medical material 100 according to the present embodiment, it is possible to provide a medical material that enables minimally invasive catheter treatment that can be released and retained at a treatment site in a living body with an easy and reliable operation (realizing locking / unlocking reversibly or irreversibly) without a complicated structure.

[0033] It should be considered that the embodiments disclosed this time are illustrative in all respects and not restrictive. The scope of the present invention is shown not by the above description but by the claims, and it is intended that all modifications within the meaning and scope equivalent to the claims are included.

Industrial Applicability

[0034] The present invention is particularly suitable for a medical material that is set in a catheter for treating a hole formed in a living tissue, can be released and retained at the treatment site, enables minimally invasive treatment, and has little possibility of remote-term problems even if the medical material remains in the body, and has favorable operability.

Explanation of Signs

[0035] 100 Medical material (closure plug) 110 First cylindrical portion 112 First end 120 Second cylindrical portion 122 Second end 130 Approximately central portion 150 Biodegradable fiber 200 Heart 250 Atrial septum 252 Hole 300 Catheter 412 Handheld joint 422 Tip joint 500 Delivery Cable (Operating Wire)

Claims

1. A medical material formed by a cylindrical body including one substantially central portion and two cylindrical portions of a mesh-like structure using a bioabsorbable wire, wherein the two cylindrical portions include a first cylindrical portion and a second cylindrical portion sandwiching the substantially central portion, having a shape in which the cylinder diameter of the substantially central portion is smaller than the cylinder diameters of other portions, the first cylindrical portion on the first end side in the longitudinal direction of the cylindrical body centered on the substantially central portion and the second cylindrical portion on the second end side which is the other end are formed, when the first end and the second end are separated centered on the substantially central portion and the cylinder diameter of the other portion is reduced and the medical material is stored in a catheter, the second end side becomes the tip side of the catheter, the medical material, includes a proximal joint joined to the mesh-like structure at the first end, and a tip joint joined to the mesh-like structure at the second end, the proximal joint has a substantially hollow cylindrical shape, the tip joint has a substantially cylindrical shape, and the substantially cylindrical shape of the tip joint is formed so as to be insertable into the substantially hollow cylinder of the proximal joint. The proximal joint and the tip joint can reversibly or irreversibly realize a lock for maintaining an integrated state and an unlock for not maintaining the integrated state, the inner diameter of the proximal joint is larger than the outer diameter of a delivery cable inserted into the catheter, the tip joint can selectively realize a joined state joined to the tip of the delivery cable and a non-joined state not joined, a delivery cable in which the tip joint and the tip of the delivery cable are joined is formed so as to be insertable through the hollow cylinder of the proximal joint from the second end side through the substantially central portion and passed to the outside of the medical material from the first end side, the tip joint includes an outer diameter portion larger than the outer diameter of the delivery cable and smaller than the inner diameter of the proximal joint, and an engaging portion larger than the outer diameter of the outer diameter portion, the proximal joint includes an inner diameter portion matching the outer diameter portion and an engaged portion larger than the inner diameter of the inner diameter portion and matching the engaging portion, when the tip joint is inserted into the proximal joint, the engaging portion of the tip joint engages with the engaged portion of the proximal joint, thereby transitioning from the unlocked state to the locked state, and The hand-held joint part is characterized in that it has a deployability such that when the engaging part is inserted into the inner diameter part, the inner diameter on the distal joint part side expands, and when the engaging part engages with the engaged part, the expansion is eliminated. A medical material.

2. The hand-held joint part having a substantially hollow cylindrical shape has a groove that communicates the outer surface and the inner surface of the substantially hollow cylinder from an end surface on the distal joint part side to a predetermined position that does not reach the end surface on the first end part side, and is along the longitudinal direction of the delivery cable. The medical material according to claim 1, wherein the deployability is realized by providing one or more grooves.

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