Medical sheet

Abstract

To provide a medical sheet which contributes to grasping of accurate dimension of a tissue in microsurgery and facilitates grasping of temperature variation of a placed portion.SOLUTION: A medical sheet 1 comprises a sheet-like body 10 and a streak part 20 formed on the body 10 and having a plurality of lines. At least one of the body 10 and the streak part 20 contains a temperature response material which varies a hue at a predetermined temperature. A pitch of the lines is 500 μm or less and the width of the lines is 100 μm or less.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a medical sheet, and more particularly to a medical sheet that is placed in an operating field and used for various measurements and the like.

Background Art

[0002] Microsurgery, which uses a surgical microscope to dissect and suture fine tissues such as blood vessels and nerves, is widely performed on various organs.

[0003] In microsurgery, a needle with a diameter of about 50 μm to 100 μm and a thread with a diameter of about 10 μm to 20 μm are used. Both the needle and the thread are fine, and extremely precise work is required. In addition, in tissue suturing, it may be required to match the dimensions of the two tissues to be sutured, and it is important to accurately grasp the dimensions of the tissue in the operating field.

[0004] As a measurement member for medical use, Patent Document 1 describes a medical adhesive tape with graduations.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] The adhesive tape with graduations described in Patent Document 1 is intended to record the course of treatment with a photograph and is used by being attached to the affected part. That is, its use on internal organs is not considered. Furthermore, in microsurgery, since an adhesive tape with graduations described in Patent Document 1 cannot be attached to the tissue to be treated, it cannot be applied.

[0007] In addition, when the temperature of the tissue rises due to the influence of lighting during surgery or the like, there is a possibility that cells may be damaged or necrotic due to protein denaturation. Therefore, there is also a need to easily determine the temperature situation within the surgical field.

[0008] In view of the above circumstances, an object of the present invention is to provide a medical sheet that can contribute to accurately grasping the dimensions of tissue during microsurgery and is easy to grasp the temperature change of the placed site.

Means for Solving the Problems

[0009] One aspect of the present invention is It includes a sheet-like main body and a scoring part formed on the main body and having a plurality of lines. a medical sheet. At least one of the main body and the scoring part contains a temperature-responsive material that changes color at a predetermined temperature. The pitch of the plurality of lines is 500 μm or less, and the width of the plurality of lines is 100 μm or less. In this medical sheet, the ruled line portion is formed by printing ink containing a temperature-responsive material on the main body.

Effects of the Invention

[0010] The medical sheet of the present invention can contribute to accurately grasping the dimensions of tissue during microsurgery and is easy to grasp the temperature change of the placed site.

Brief Description of the Drawings

[0011]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Best Mode for Carrying Out the Invention

[0012] Hereinafter, a first embodiment of the present invention will be described with reference to FIGS. 1 and 2. FIG. 1 is a plan view of a medical sheet 1 according to this embodiment. The medical sheet 1 includes a sheet-shaped main body 10 and a ruled portion 20 formed on the main body 10.

[0013] The main body 10 is formed of a biocompatible material. Specifically, as the biocompatible material, there are silicone, polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polyester, polyvinyl chloride (PVC), polymethyl methacrylate, polyether ether ketone (PEEK), polyether sulfone (PES), polysulfone (PSU), polyphenyl sulfone (PPSU), polyacetal (POM), polyphenyl sulfide (PPS), polyether imide (PEI), polyimide (PI), polylactic acid, polyglycolic acid, polycaprolactone, polycarbonate, polyethylene, polypropylene and other polymers, copolymers of these polymers, and metals such as titanium alloys, stainless steels, cobalt alloys and their oxides, and thermosetting elastomers such as silicone rubber, urethane rubber, fluororubber, natural rubber, synthetic rubber, and elastic materials such as thermoplastic elastomers such as polystyrene-based (TPS), polyolefin-based (TPO), urethane-based (TPU), and polyester-based (TPEE). Further, the binder of the polymer shown above may contain inorganic powder. The inorganic powder can be silica, alumina, zinc oxide, and titanium oxide. The content of the inorganic powder can be 5% to 70% by weight. Further, an inorganic pigment may be contained. The form of the main body 10 may be either film-like or plate-like. Further, it may be either flexible with flexibility or rigid that does not substantially bend, and can be appropriately selected in consideration of the target organ, procedure, etc.

[0014] The main body 10 only needs to be opaque, specifically, the transmittance may be 1% or less. If the biological tissue in contact with the surface opposite to the surface on which the scribed portion 20 of the main body 10 is provided cannot be visually recognized through the main body 10, the tissue during microsurgery can be accurately confirmed. The color of the main body 10 is preferably the complementary color of the biological tissue. This complementary color can be formed by colors from blue, blue with a green tint, blue-green, green with a blue tint, green, green with a yellow tint, to yellow-green from blue to yellow-green. The colors from blue to yellow-green correspond to B, BG, G, GY in the Munsell color system. By setting the color of the main body 10 to the colors from blue to yellow-green, the biological tissue becomes easier to visually recognize. Specifically, the ranges of L*, a, and b in the L*ab color space of the main body 10 are preferably 25 or more and 80 or less, -80 or more and 0 or less, and -50 or more and 50 or less, respectively.

[0015] In the main body 10, among visible light (wavelength band of about 350 nm to 800 nm), the spectral reflectance at 570 nm to 800 nm is preferably 20% or less. In the case of forming the main body with the above-mentioned metal, etc., the above color can be realized by full-surface printing of paint, etc. When the brightness of the main body 10 is low, the contrast with the biological tissue is preferably good. The peak reflectance of visible light of the main body having such brightness is generally 10% or less.

[0016] There is no particular limitation on the thickness of the main body 10, but it can be 15 μm or more and 2 mm or less. In the case of a highly elastic material, it can be about 0.1 mm to 1.0 mm, in the case of a low-elastic material, it can be about 0.02 mm to 0.2 mm, and in the case of a metal, it can be about 0.01 mm to 0.1 mm.

[0017] The shape in plan view of the main body 10 illustrated in this embodiment is a rounded rectangle, but the shape in plan view is not limited to this, and can be appropriately determined, such as a triangle, a circle, etc. The shape in plan view of the main body 10 is preferably a rounded polygon. In such a form, it is difficult to damage the tissue and it is easy to pick up with tweezers or a manipulator. Also, the polygon can be a convex hull. If it is a convex hull, it is difficult to catch on the tissue.

[0018] The scribed portion 20 is formed on the main body 10 by printing. The ruled line portion 20 is composed of a plurality of lines. FIG. 1 shows an example in which a plurality of orthogonal lines are arranged to form a grid, but the arrangement pattern of the lines in the ruled line portion 20 is not limited to this and can be appropriately set according to the object to be measured or the like. For example, a ruled line shape composed of only a plurality of lines extending in parallel, a concentric circle shape, a radial shape, etc. can be exemplified.

[0019] The width of the lines in the ruled line portion 20 is 100 μm or less, and the distance (pitch) between adjacent lines is 500 μm or less. Within this range, the ruled line portion 20 may include two or more types of lines with different widths, or may have a plurality of regions with different pitches (distance between lines). Such a ruled line portion with such dimensions is difficult to see with the naked eye, but can be suitably visually recognized when viewed with a magnifying glass in microsurgery.

[0020] The ink for forming the ruled line portion 20 has a temperature-responsive material whose color changes with temperature and a binder. Examples of the temperature-responsive material include inorganic compounds such as mercury iodide and dimethylammonium compounds, liquid crystals such as cholesterol derivatives and cyanobiphenyls, leuco dyes, spiropyrans, salicylideneanilines, viologens, and organic compounds such as polydiacetylenes, which cause reversible or unidirectional discoloration accompanying intermolecular forces, transitions, dehydration reactions, steric coordination, or changes in molecular structure of each substance. The temperature-responsive material may be used as it is, or may be mixed into the ink in a state encapsulated in microcapsules or the like.

[0021] It is preferable that one of the colors before and after the change of the temperature-responsive material is easily visible on the main body 10, that is, it has a complementary color relationship with the color of the main body 10. Those that become transparent in one of the states before and after the change can also be used as the temperature-responsive material in the present embodiment. The temperature-responsive material preferably changes color within the temperature range of 30°C to 80°C, and more preferably changes color within the temperature range of 40°C to 50°C. If the color change temperature is close to the temperature at which the tissue is damaged, it is possible to grasp an unfavorable state for the surgical site at an early stage, and by appropriately responding, damage to the tissue can be reduced.

[0022] Only one type of temperature-responsive material may be used, or two or more types may be mixed and used.

[0023] In order to adjust the color of the line, a pigment that does not change color with temperature may be mixed into the ink. As the pigment, either an organic pigment or an inorganic pigment can be used. As the inorganic pigment, oxides, hydroxides, sulfides, selenides, ferrocyanides of metals such as titanium, zinc, gold, silver, copper, and iron, or chromates, sulfates, carbonates, silicates, and phosphates of these metals can be used. Furthermore, examples include simple substances of the above-mentioned metals or their alloys, etc., carbon, bismuth oxychloride which is a pearl pigment, mica titanium, and fish scale foil. Among them, titanium dioxide (titania), zinc oxide, talc, silica, mica, alumina, barium sulfate, calcium carbonate, magnesium carbonate, barium silicate, calcium silicate, metal soap, and silicone, which have biocompatibility, are preferable. Examples of the organic pigment include nitroso-based, nitro-based, azo-based, lake-based, phthalocyanine-based, condensed polycyclic materials, and other carbon compounds.

[0024] A resin can be used as the binder. The resin can form a composition, and the composition can be formed by mixing oligomers and polymers. The resin can be a soluble one. The resin may be a curable resin. The curable resin can be an ionizing radiation-curable resin or a thermosetting resin. The ionizing radiation-curable resin can be an ultraviolet-curable resin or an electron beam-curable resin. The type of resin can be an acrylic resin, a urethane resin, an epoxy resin, a polyester resin, a thiol resin, or a mixture thereof. As the acrylic resin, a fluorine-based acrylic resin, a silicone-based acrylic resin, an epoxy acrylate resin, an acrylonitrile styrene resin, or a mixture thereof can be used. As other resins, a methyl styrene resin, a fluorene resin, a polypropylene, a PET (polyethylene terephthalate), a PC (polycarbonate), a PS (polystyrene), a COC (cyclic olefin copolymer), a COP (cycloolefin polymer), an MS (methacrylic acid styrene copolymer), an AS (acrylonitrile styrene copolymer), a PEN (polyethylene naphthalate), a PI (polyimide), a phenol resin, a melamine resin, an epoxy resin, an alkyd, etc. can be used.

[0025] In addition to the above, it is also possible to use engineering plastics such as PBT (polybutylene terephthalate), POM (polyoxymethyl), PA (polyamide), PPS (polyphenyl sulfide), etc., and super engineering plastics as the binder.

[0026] For the ink for forming the ruled line portion 20, it is preferable to properly use aqueous ink or non-aqueous ink according to the characteristics of the surface of the main body 10. When the surface of the main body 10 is hydrophilic, it is preferable to use aqueous ink. When the surface of the main body 10 is hydrophobic, it is preferable to use non-aqueous ink. Various solvents can be used to prepare the solid content and viscosity of the ink. For example, water (purified water) or alcohol can be used in aqueous inks. In non-aqueous inks, solvents with high boiling points that are difficult to evaporate at room temperature (such as aliphatic hydrocarbons, glycol ethers, and higher alcohols) or solvents with low boiling points that are easy to evaporate at room temperature (such as MEK, ethanol, and acetone) can be used alone or in combination. In addition, dodecane, tetradecane, toluene, etc. can also be used.

[0027] The ink may contain organic fine particles or inorganic fine particles. Specific examples include acrylic particles, styrene particles, styrene-acrylic particles and their cross-linked products, melamine-formalin condensate particles, polyurethane-based particles, polyester-based particles, silicone-based particles, fluorine-based particles, epoxy particles, copolymers thereof, clay compound particles such as smectite, kaolinite, and talc, inorganic oxide particles such as silica, titanium oxide, alumina, silica alumina, zirconia, zinc oxide, barium oxide, strontium oxide, and inorganic fine particles such as calcium carbonate, barium carbonate, magnesium carbonate, barium chloride, barium sulfate, barium nitrate, barium hydroxide, aluminum hydroxide, strontium carbonate, strontium chloride, strontium sulfate, strontium nitrate, strontium hydroxide, and glass particles. These particles can be used alone or in appropriate combinations. Furthermore, they may be used after surface treatment by coating, vapor deposition, etc.

[0028] There is no particular limitation on the printing method for forming the ruled portion 20. Examples of the printing method include offset printing, gravure printing, flexographic printing, screen printing, gravure offset printing, reverse offset printing, screen offset printing, tampo printing, inkjet printing, etc. Among these, gravure offset printing and screen offset printing are particularly suitable because they can stably form a narrow line.

[0029] The ink for forming the ruled line portion 20 is preferably made of a biocompatible material. After forming the ruled line portion 20 with ink that is not made of a biocompatible material, the biocompatibility of the medical sheet 1 can also be ensured by covering the ink portion with a biocompatible coating having transparency. In this case, the coating may cover only the ruled line portion 20 or may cover the entire surface of the main body 10. As the material for the coating, a biocompatible material that can be used for the ink forming the main body 10 and the ruled line portion 20 can be used. Preferably, silicone resin, fluororesin, etc. can be exemplified.

[0030] The operation during use of the medical sheet 1 configured as described above will be described. The medical sheet 1 is placed as it is or cut to an appropriate size and placed in the operating field where the treatment is performed. When the organ or tissue to be treated is placed at an appropriate position on the medical sheet 1 or positioned slightly above the medical sheet 1, the dimensions of the organ or tissue can be grasped based on the ruled line portion 20.

[0031] Due to heat from the illumination illuminating the surgical field or the like, the temperature of the ruled line portion 20 rises, and when it reaches a temperature at which a temperature change occurs, the color of the ruled line portion 20 changes. The user can thereby intuitively and easily recognize the temperature of the site where the medical sheet 1 is placed, and by taking appropriate measures or treatments as necessary, it is possible to suitably prevent damage to the tissue to be treated, its surrounding tissue, or a graft, etc. If the color change of the temperature-responsive material is reversible, it is also easy to grasp that the treatment for lowering the temperature has been successful.

[0032] The mode of the color change can be set in various ways depending on the temperature-responsive material contained in the ruled line portion 20. Some of them are exemplified below. · The ruled line portion 20 changes its color and lightness while maintaining visibility with respect to the main body 10. ·As shown in FIG. 2, the color of the lined portion 20 becomes the same color as or transparent to the main body 10, making it difficult to visually recognize. In this case, it becomes difficult for the user to grasp the dimensions of the organ or tissue, and the user notices the temperature change. In any of the above aspects, the user can intuitively and easily recognize the temperature change.

[0033] If the color change temperature of the lined portion 20 is a value slightly lower than the temperature at which the tissue is damaged, it is easy to prevent damage by recognizing the temperature change before the tissue is damaged. If the color change temperature of the lined portion 20 is equal to or slightly higher than the temperature at which the tissue is damaged, it is easy to minimize the damage received by the tissue or the like by quickly responding after recognizing the color change.

[0034] In the present embodiment, it is preferable that there is a brightness difference of a certain level or more between the lined portion 20 and the main body 10, as this results in good contrast. For example, when the difference in the average reflectance (%) of visible light is about 30 points, the contrast is good. Alternatively, the contrast between the lined portion 20 and the main body 10 can be a color density difference of 0.1 or more and 2.0 or less, and preferably 0.5 or more and 1.5 or less in order to further improve visibility.

[0035] The height of the lined portion 20 (the thickness of the layer formed on the main body 10) is preferably 1 μm or more and 10 μm or less for easy visibility. Examples of the cross-sectional shape of the lined portion 20 include a semi-circular shape, a semi-elliptical shape, a triangular shape, a trapezoidal shape, a rectangular shape, a trapezoidal or rectangular shape with a convex curved surface at the upper part. If there is an edge at the corner of the cross-sectional shape, blood or cleaning liquid is likely to remain on the lined portion 20 due to surface tension, but if the corner portion in the cross-sectional shape is rounded, it is preferable because blood and cleaning liquid are less likely to stay on the lined portion 20. Furthermore, preferably, when it is a semi-circular shape, a semi-elliptical shape, a triangular shape, or a trapezoidal shape, blood, cleaning liquid, etc. are less likely to stay on the lined portion 20 and it is easier to flow from the medical sheet, so it is easy to maintain the visibility of the lined portion 20 during microsurgery. The height of the lined portion 20 can be easily adjusted by, for example, printing it repeatedly at the same location when printing ink on the main body 10.

[0036] The second embodiment of the present invention will be described with reference to FIG. 3. In the following description, for components common to those already described, the same reference numerals will be given and redundant descriptions will be omitted.

[0037] FIG. 3 is a plan view of the medical sheet 101 according to this embodiment. The medical sheet 101 includes a main body 110 and a ruled line portion 120 provided on the main body 110. Since the ruled line portion 120 of this embodiment does not contain a temperature-responsive material, its color does not change with temperature. Instead, the main body 110 is formed to include a temperature-responsive material. That is, the medical sheet 101 according to this embodiment is configured such that the color of the main body 110 changes with temperature.

[0038] The method of incorporating the temperature-responsive material into the main body 110 can be appropriately selected. When the main body 110 is formed of a synthetic resin, an elastomer, or the like, the temperature-responsive material can be incorporated by mixing it with the base material and kneading it. In the case where the main body 110 is a hard sheet or the like, it can be incorporated by forming a colored layer containing the temperature-responsive material on the surface of the main body.

[0039] The usage procedure and effects of the medical sheet 101 are generally the same as those of the first embodiment. Due to heat from lighting or the like, when the temperature of the main body 110 rises and reaches a temperature at which a temperature change occurs, the color of the main body 110 changes. As a result, the user can intuitively and easily recognize the temperature of the part where the medical sheet 101 is placed. FIG. 4 shows the medical sheet 101 with the color of the main body 110 changed. In FIG. 4, as the color of the main body 110 approaches the ruled line portion 120, the visibility of the ruled line portion 120 decreases.

[0040] The medical sheet according to the present invention will be further described using examples. The present invention is not limited in any way by the specific contents of the following examples.

[0041] (Example 1) Example 1 is an example according to the second embodiment. A green temperature-responsive material was kneaded into a two-component curable silicone resin, and cast molding was performed to obtain a green body with a thickness of 0.1 mm. The temperature-responsive material is derived from a leuco dye and becomes colorless and transparent at 40°C or higher.

[0042] On the body, a grid-like ruled line portion with a pitch of 100 μm was formed by printing. The basic line width was set to 20 μm, and for the purpose of measurement reference, every fifth line was made wider at 30 μm. The ink for forming the ruled line portion is a white ink in which 40 wt% of titanium oxide is added as a pigment to the silicone resin and does not contain a temperature-responsive material. After printing, the ink was heat-cured at 140°C for 10 minutes to obtain a medical sheet according to Example 1. When the line width of the ruled line portion was measured, it increased by about 2% compared to before heating, but there was no change of 10% or more, and there was no problem with the dimensional accuracy as a scale.

[0043] When the medical sheet of Example 1 was observed with a binocular microscope at a magnification of 40 times, the contrast between the ruled line portion and the body was good, and the ruled line portion could be clearly visually recognized. When a pig's blood vessel was placed on the medical sheet and observed with a binocular microscope, the dimensions such as length and diameter could be easily grasped based on the ruled line portion.

[0044] When the medical sheet was immersed in physiological saline and heated, when the temperature of the physiological saline reached 45°C, the body became a cloudy white color derived from the silicone resin. As a result, the appearance of the medical sheet changed greatly and the visibility of the ruled line portion was clearly reduced, and it was easy to grasp that the temperature had reached 40°C or higher.

[0045] (Example 2) Example 2 is an example according to the first embodiment. As the body, a green sheet (thickness 0.3 mm) made of silicone resin was used. This body does not contain a temperature-responsive material. On the main body, a grid-like ruled line portion with a pitch of 500 μm was formed by printing. The basic line width was set to 40 μm, and for the purpose of a measurement reference, every five lines were made wider at 50 μm. The ink for forming the ruled line portion is a blue ink obtained by adding 50 wt% of a temperature-responsive material to a silicone resin. As the temperature-responsive material, a white material in which a cholesteryl derivative is encapsulated in microcapsules was used. This temperature-responsive material changes color at 50°C or higher and becomes colorless. After printing, the ink was heat-cured at 140°C for 5 minutes to obtain the medical sheet according to Example 2. When the line width of the ruled line portion was measured, it increased by about 2% compared to before heating, but there was no change of 10% or more, and there was no problem with the dimensional accuracy as a scale.

[0046] When the medical sheet of Example 2 was observed with a binocular microscope at a magnification of 40 times, the contrast between the ruled line portion and the main body was good, and the ruled line portion could be clearly visually recognized. When a pig's blood vessel was placed on the medical sheet and observed with a binocular microscope, dimensions such as length and diameter could be easily grasped based on the ruled line portion.

[0047] When the medical sheet was immersed in physiological saline and heated, when the temperature of the physiological saline reached 60°C, the ruled line portion became colorless. As a result, the appearance of the medical sheet changed greatly and the visibility of the ruled line portion clearly decreased, and it was easily possible to grasp that the temperature had reached 60°C or higher.

[0048] As described above, each embodiment of the present invention has been described in detail with reference to the drawings, but the specific configuration is not limited to this embodiment, and configurations such as changes and combinations within the scope not departing from the gist of the present invention are also included. Some changes are exemplified below, but these are not all, and other changes are also possible. These changes may be appropriately combined in two or more.

[0049] · In the medical sheet according to the present invention, only a part of the ruled portion may contain a temperature-responsive material. In the medical sheet 1A of the modified example shown in FIG. 5, among the ruled portions 20A, only the temperature display portions 21 formed in some of the grids contain a temperature-responsive material and change color at a predetermined temperature. By doing so, it is possible to easily grasp the temperature change without changing the visibility of a plurality of lines in the ruled portion 20A. If the color before the change of the temperature display portion 21 is made transparent, the temperature display portion becomes visible for the first time when the predetermined temperature is reached, so that the measurement until then can be easily performed.

[0050] · In each of the above-described examples, there is a region without a line at the peripheral portion of the main body in plan view, but this is not essential, and lines may be provided on the entire surface of the main body. · Small pieces for easy gripping with forceps or the like may protrude from the periphery of the main body. · The visible light reflectance of the main body may have a plurality of peaks. Even in this case, if at least one peak exists within the range of wavelengths of 450 nm to 570 nm, the contrast with the living tissue becomes good and the visibility is excellent.

[0051] · Even if the ink forming the line or the information portion has biocompatibility, a coating may be provided. During the use of the medical sheet, since physiological saline or the like is continuously applied to prevent drying, the coating can suppress the attack on the line or the information portion by physiological saline or the like.

[0052] · In the medical sheet according to the present invention, an information portion indicating the values of the line width and the pitch may be provided on the main body. In the case where the pitch is small or the like, a part of the ruled portion may be omitted at the portion where the information portion is provided. Also, as in the above-described modified example, a configuration may be adopted in which only the information portion contains a temperature-responsive material.

[0053] · The total thickness of the medical sheet combining the main body and the scored part can be, for example, 0.02 mm or more and 1.0 mm or less. By setting it to 0.02 mm or more, the transportability during manufacturing is maintained, and it is easy to ensure the dimensional accuracy of the scored part. By being 1.0 mm or less, it is easy to exhibit flexibility and easy to use in microsurgery.

[0054] · The scored part does not necessarily have to be formed directly on the main body. For example, the scored part may be formed on the main body by joining a sheet on which the scored part is formed to the main body by an adhesive, heat fusion, thermocompression bonding, or the like. Examples of usable adhesives include vinyl acetate, acrylic, urethane, rubber, and silicone adhesives. Considering maintaining sufficient bonding in the assumed usage environment, the storage elastic modulus of the adhesive is preferably 1.0E+04 Pa or more at 100°C. The adhesive may be one that has been processed into a sheet in advance, or may be directly applied or coated on the main body. Surface treatment such as corona treatment may be performed on the bonding surface of the main body to increase the bonding strength.

[0055] · Both the main body and the scored part may contain a temperature-responsive material.

Explanation of reference numerals

[0056] 1, 1A, 101 Medical sheet 10, 110 Main body 20, 20A, 120 Scored part

Claims

1. A sheet-shaped body, A scoring part formed on the body and having a plurality of lines, Comprising, At least one of the body and the scoring part contains a temperature-responsive material that changes color at a predetermined temperature, The color change of the temperature-responsive material is reversible, The pitch of the plurality of lines is 500 μm or less, The width of the plurality of lines is 100 μm or less, Medical sheet.

2. A sheet-shaped body, A scoring part formed on the body and having a plurality of lines, Comprising, At least one of the body and the scoring part contains a temperature-responsive material that changes color at a predetermined temperature, The pitch of the plurality of lines is 500 μm or less, The width of the plurality of lines is 100 μm or less, The scoring part is formed by printing ink containing the temperature-responsive material on the body, Medical sheet.

3. The body has flexibility, The medical sheet according to claim 1 or 2.

4. Further comprising a coating covering the scoring part, The medical sheet according to claim 1 or 2.

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