Oral stain-removing composition

Abstract

To provide an oral composition having a stain removal effect.SOLUTION: An oral composition contains sodium lauryl sulfate, and a polyoxyethylene-polyoxypropylene block copolymer having a structure with polyoxyethylene chains bonded to both ends of a polyoxypropylene chain. The content of the sodium lauryl sulfate is 0.01-10 mass% and the content of the polyoxyethylene-polyoxypropylene block copolymer is 0.1-40 mass%.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition. Stain removal

Background Art

[0002] Stains are known as one of the factors causing tooth discoloration. A stain is a pigment deposit in which a protein film (pellicle) covering the tooth is insolubilized by polyphenols contained in tea or the like and firmly adheres to the tooth surface. Patent Document 1 discloses a technique for suppressing the formation of stains by an oral composition containing a polyoxyethylene-polyoxypropylene block copolymer.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] The present inventors have found that a synergistic stain-removing effect can be obtained when sodium lauryl sulfate and a specific polyoxyethylene-polyoxypropylene block copolymer are used in combination. An object of the present invention is to provide an oral composition having a stain-removing effect. Stain removal composition (Hereinafter referred to as an oral composition.)

Means for Solving the Problems

[0005] The oral composition for solving the above problems contains sodium lauryl sulfate and a polyoxyethylene-polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of the polyoxypropylene chain. The content of the sodium lauryl sulfate is 0.01 to 10% by mass, and the content of the polyoxyethylene-polyoxypropylene block copolymer is 0.1 to 40% by mass.

[0006] The above oral composition is in a solid or semi-solid form, and preferably the polyoxyethylene ratio of the polyoxyethylene-polyoxypropylene block copolymer is 50% or more.

[0007] The above oral composition is in a solid or semi-solid form, and preferably the content of the sodium lauryl sulfate is 1.7 to 10% by mass. The above oral composition is in a solid or semi-solid form, and preferably the content of the polyoxyethylene-polyoxypropylene block copolymer is 8 to 15% by mass.

[0008] The above oral composition is in a liquid form, and preferably the polyoxyethylene ratio of the polyoxyethylene-polyoxypropylene block copolymer is 50 to 70%. The above oral composition is in a liquid form, and preferably the content of the sodium lauryl sulfate is 0.01 to 0.25% by mass.

Advantages of the Invention

[0009] According to the oral composition of the present invention, stains attached to teeth can be removed.

Modes for Carrying Out the Invention

[0010] Hereinafter, the oral composition of the present embodiment will be specifically described. The oral composition of the present embodiment contains (A) sodium lauryl sulfate and (B) a polyoxyethylene-polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of the polyoxypropylene chain.

[0011] (A) Sodium lauryl sulfate is an anionic surfactant represented by the chemical formula NaC 12 H 25 SO4. For sodium lauryl sulfate, for example, commercially available products can be used. Note that the number of carbon atoms in the alkyl group described in the commercially available product means that the number of carbon atoms in the alkyl group of a substance above a certain ratio (for example, 50% or more) is that value.

[0012] The content of sodium lauryl sulfate in the oral composition is 0.01 to 10% by mass, and more preferably 0.01 to 5% by mass. Further, when the content of sodium lauryl sulfate is applied as a solid or semi-solid oral composition such as powder, paste, liquid, etc., it is preferably 1.7 to 10% by mass, and when applied as a liquid oral composition, it is preferably 0.01 to 0.25% by mass. In particular, when applied as a liquid oral composition, by setting the content of sodium lauryl sulfate to 0.25% by mass or less, it is possible to suppress excessive irritation to the user.

[0013] (B) A polyoxyethylene - polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of a polyoxypropylene chain is a non - ionic surfactant having a structure represented by the following general formula (1).

[0014] [Chemical formula] In the general formula (1), x, y, and z representing the average number of added moles of polyoxyethylene or polyoxypropylene are each independently a numerical value of 1 or more.

[0015] In general formula (1), the ratio of polyoxyethylene to polyoxypropylene is not particularly limited. For example, the mass ratio occupied by polyoxyethylene is preferably 10% or more, and more preferably 50% or more. The upper limit of the mass ratio occupied by polyoxyethylene is, for example, 80%. Further, when applied as a solid or semi-solid oral composition, the mass ratio occupied by polyoxyethylene is preferably 50% or more, and when applied as a liquid oral composition, it is preferably 50 to 70%.

[0016] As the polyoxyethylene-polyoxypropylene block copolymer, for example, commercially available products can be used. Note that the average added mole numbers of polyoxyethylene and polyoxypropylene described in commercially available products mean a certain range including those numerical values. For example, the average added mole number "2" means the range of "1.5 to 2.4", and the average added mole number "3" means the range of "2.5 to 3.4".

[0017] The content of the polyoxyethylene-polyoxypropylene block copolymer in the oral composition is 0.1 to 40% by mass, and more preferably 8 to 15% by mass. In particular, when applied as a solid or semi-solid oral composition, the content of the polyoxyethylene-polyoxypropylene block copolymer is preferably 8 to 15% by mass.

[0018] The application form of the oral composition is not particularly limited, and it can be used, for example, as a pharmaceutical or quasi-drug. As the uses of the oral composition, known ones can be appropriately adopted, and examples include chewing dentifrices, powdered dentifrices, liquid dentifrices, lubricating dentifrices, and mouthwashes. The dosage form of the oral composition is not particularly limited, and it can be appropriately prepared, for example, in a solid or semi-solid form, a liquid form, etc. by a known method (especially a conventional method). Examples of the solid or semi-solid form include powder, paste, liquid, etc. according to the dosage form of dentifrices defined by the Japan Toothbrush Industry Association.

[0019] The oral composition can contain other components other than (A) sodium lauryl sulfate and (B) polyoxyethylene-polyoxypropylene block copolymer according to the application form, use, etc. Examples of other components include components formulated in known oral compositions, such as water, antibacterial agents, anti-inflammatory agents, fragrances, wetting agents, surfactants other than those mentioned above, abrasives, alcohols, thickeners, sweetening components, medicinal components, stabilizers, and pH adjusters. Each of the other components may be applied alone, or two or more of them may be combined and applied.

[0020] Specific examples of antibacterial agents include cetylpyridinium chloride, parabens, sodium benzoate, triclosan, chlorhexidine hydrochloride, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, and the like.

[0021] Specific examples of anti-inflammatory agents include glycyrrhetinate, tranexamic acid, ε-aminocaproic acid, peony extract, and the like. Specific examples of fragrances include anethole, eugenol, linalool, menthol, carvone, limonene, wintergreen, methyl salicylate, cionel, thymol, clove oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil, osimen oil, citronellol, water-soluble fragrances of various fragrances, and the like.

[0022] Specific examples of wetting agents include polyhydric alcohols such as sorbitol, ethylene glycol, propylene glycol, 1,3-butylene glycol, and the like. Examples of surfactants include nonionic surfactants other than polyoxyethylene-polyoxypropylene block copolymers, anionic surfactants other than sodium lauryl sulfate, and amphoteric surfactants.

[0023] Specific examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid ester and maltose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester, sorbitan fatty acid esters such as sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monolaurate and polyoxyethylene sorbitan monostearate, fatty acid alkanolamides such as lauric acid diethanolamide, polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether and polyoxyethylene oleyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, alkyl glucosides such as lauryl glucoside and decyl glucoside, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil, glycerin fatty acid esters, and the like.

[0024] Specific examples of anionic surfactants include sulfate esters such as sodium polyoxyethylene lauryl ether sulfate, acyl amino acid salts such as sodium cocoyl sarcosinate, sodium lauroyl methyl alaninate, and sodium lauroyl sarcosinate, and sodium cocoyl methyl taurine.

[0025] Specific examples of amphoteric surfactants include N-alkyl diethylaminoethyl glycines such as N-lauryl diethylaminoethyl glycine and N-myristyl diethylaminoethyl glycine, N-alkyl-N-carboxymethyl ammonium betaines, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium, and the like.

[0026] Specific examples of abrasives include calcium carbonate, magnesium carbonate, dicalcium phosphate, tricalcium phosphate, magnesium phosphate, zeolite, sodium metaphosphate, aluminum hydroxide, magnesium hydroxide, calcium pyrophosphate, red iron oxide, calcium sulfate, anhydrous silicic acid, and the like.

[0027] Specific examples of the alcohols include ethyl alcohol, lauryl alcohol, myristyl alcohol and the like. Specific examples of the thickening agent include sodium polyacrylate, carrageenan, sodium carboxymethyl cellulose, sodium alginate, xanthan gum, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, propylene glycol alginate ester and the like.

[0028] Specific examples of the sweetening component include saccharin, sodium saccharin, sucralose, stevioside, acesulfame potassium, aspartame, xylitol, maltitol, erythritol and the like.

[0029] Specific examples of the medicinal component include fluorides such as sodium monofluorophosphate, sodium fluoride, stannous fluoride, strontium fluoride; condensed phosphates such as sodium pyrophosphate and sodium polyphosphate; phosphates such as sodium hydrogen phosphate and trisodium phosphate; vitamin agents such as ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, tocopherol acetate; glucanase enzymes such as dextranase, mutanase; degrading enzymes such as protease, lysozyme; inorganic salts such as zinc chloride, zinc citrate, strontium chloride, potassium nitrate; zeolite, chlorophyll, glycerophosphate, sodium chloride, aluminum lactate, strontium chloride and the like.

[0030] Specific examples of the stabilizer include legal dyes such as Green No. 1, Blue No. 1, Yellow No. 4 and titanium oxide and the like. Specific examples of the pH adjuster include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, and various salts thereof such as potassium salts, sodium salts and ammonium salts, and sodium hydroxide and the like. The oral composition is preferably adjusted so that the pH is in the range of 5 to 11, particularly 6 to 9, by blending a pH adjuster. The blending amount of the pH adjuster in the oral composition can be appropriately set within a range that does not interfere with the effects of the present invention.

[0031] Formulation examples of the oral composition of the present embodiment are shown in Tables 1, 2, and 3. Formulation example 1 shown in Table 1 is a formulation example when applied as a dentifrice which is a solid or semi-solid oral composition, formulation example 2 shown in Table 2 is a formulation example when applied as a liquid dentifrice which is a solid or semi-solid oral composition, and formulation example 3 shown in Table 3 is a formulation example when applied as a liquid oral composition. In addition, the numerical values in the "Blending amount" column of Tables 1, 2, and 3 are in mass %, and are prepared so as to be 100 mass % in total.

[0032]

Table 1

[0033]

Table 2

[0034]

Table 3

[0035] (1) The oral composition contains sodium lauryl sulfate and a polyoxyethylene-polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of a polyoxypropylene chain. The content of sodium lauryl sulfate is 0.01 to 10 mass %, and the content of the polyoxyethylene-polyoxypropylene block copolymer is 0.1 to 40 mass %.

[0036] According to the above configuration, a synergistic stain removal effect can be obtained as compared with the case where sodium lauryl sulfate and the polyoxyethylene-polyoxypropylene block copolymer are used alone. Therefore, the stain adhering to the teeth can be effectively removed.

[0037] (2) The oral composition is in solid or semi-solid form, and the polyoxyethylene ratio of the polyoxyethylene-polyoxypropylene block copolymer is 50% or more. According to the above configuration, a high stain removal effect can be obtained.

[0038] (3) The oral composition is in solid or semi-solid form, and the content of sodium lauryl sulfate is 1.7 to 10% by mass. According to the above configuration, a high stain removal effect can be obtained. (4) The oral composition is in solid or semi-solid form, and the content of the polyoxyethylene-polyoxypropylene block copolymer is 8 to 15% by mass. According to the above configuration, a high stain removal effect can be obtained.

[0039] (5) The oral composition is in liquid form, and the polyoxyethylene ratio of the polyoxyethylene-polyoxypropylene block copolymer is 50 to 70%. According to the above configuration, a high stain removal effect can be obtained.

[0040] (6) The oral composition is in liquid form, and the content of sodium lauryl sulfate is 0.01 to 0.25% by mass. According to the above configuration, while obtaining a high stain removal effect, it is possible to suppress giving excessive irritation to the user.

Examples

[0041] The oral composition of the present invention will be described in more detail based on the following test examples. Note that the present invention is not limited to the configurations described in the examples column. In the examples column, regarding poloxamer, the total number of average added moles of polyoxyethylene (x + z) is abbreviated as "POE", the average added moles of polyoxypropylene (y) is abbreviated as "PO", and the mass ratio occupied by polyoxyethylene is abbreviated as "EO ratio".

[0042] <Test 1> (A) Sodium lauryl sulfate and (B) a polyoxyethylene-polyoxypropylene block copolymer-containing oral composition and an oral composition in which one of (A) sodium lauryl sulfate and (B) a polyoxyethylene-polyoxypropylene block copolymer is different from other components were prepared, and their stain removal effects were evaluated.

[0043] (Preparation of Test Examples 1 to 13) Oral compositions of Test Examples 1 to 13 were prepared according to the formulations shown in Tables 3 to 5. The numerical values in the "Formulation Column" of Tables 4 to 6 are in mass%, and they were prepared so as to be 100 mass% in total. In this test, the following polyoxyethylene-polyoxypropylene block copolymers B and C were used. In each table, the polyoxyethylene-polyoxypropylene block copolymer is described by omitting "block copolymer" as "copolymer".

[0044] Polyoxyethylene-polyoxypropylene block copolymer B (Copolymer B): POE(25)PO(30), EO ratio 50% (Adeka Pluronic L-64 manufactured by ADEKA Corporation) Polyoxyethylene-polyoxypropylene block copolymer C (Copolymer C): POE(116)PO(66), EO ratio 60% (Pluracare L1220 manufactured by BASF) (Evaluation of Stain Removal Effect) A hydroxyapatite (HAP) disk with a diameter of 1 cm was used as a tooth model. After immersing the HAP disk in ion-exchanged water for 2 minutes and then naturally drying it for 2 hours, a pre-adhesion HAP disk was obtained. Using a fluorescence spectroscopic concentration meter (FD-5 manufactured by Konica Minolta Japan), the color difference (L * value, a * value, b * value) of the pre-adhesion HAP disk was measured, and each obtained measurement value was set as L * 0, a * 0, b * 0.

[0045] Next, an adhesion treatment was performed to adhere the stain to the HAP disk before adhesion. The adhesion treatment was repeated 10 times by immersing in a 2% bovine serum albumin aqueous solution for 10 minutes, ion-exchanged water for 1 minute, a 0.2% chlorhexidine gluconate solution for 2 minutes, ion-exchanged water for 1 minute, a 0.3% ammonium ferric citrate aqueous solution for 2 minutes, ion-exchanged water for 1 minute, a black tea solution for 10 minutes, and ion-exchanged water for 1 minute in this order.

[0046] The HAP disk after the adhesion treatment was air-dried for 2 hours to obtain the HAP disk after adhesion. Using a color difference meter, the color difference (L * value, a * value, b * value) of the HAP disk after adhesion was measured, and each obtained measurement value was designated as L * 1, a * 1, b * 1.

[0047] Next, after performing a removal treatment by immersing the HAP disk after adhesion in the oral composition of each test example for 1 minute and ion-exchanged water for 1 minute in this order, it was air-dried for 2 hours to obtain the HAP disk after removal. Using a color difference meter, the color difference (L * value, a * value, b * value) of the HAP disk after removal was measured, and each obtained measurement value was designated as L * 2, a * 2, b * 2. Then, using the following formulas (1) to (3), the stain removal rate ΔE was calculated. The results are shown in the "Removal Rate" columns of Tables 4 to 6.

[0048] ΔE1 = {(L * 1 - L * 0) 2 + (a * 1 - a * 0) 2 + (b * 1 - b * 0) 2} 1 / 2 …(1) ΔE2 = {(L * 2 - L * 0) 2 + (a * 2 - a* 0) 2 +(b * 2 - b * 0) 2} 1 / 2 …(2) ΔE(%) = 100 - (ΔE2 / ΔE1)×100 …(3)

[0049]

Table 4

[0050]

Table 5

[0051]

Table 6

[0052] <Test 2> (B) Oral compositions with different types of polyoxyethylene - polyoxypropylene block copolymers were prepared and their stain removal effects were evaluated.

[0053] (Test Examples 14 - 24) Oral compositions of Test Examples 14 to 24 were prepared according to the formulations shown in Tables 7 and 8. The numerical values in the "Formulation Column" of Tables 7 and 8 are in mass %, and the formulations were prepared so that the total was 100 mass %. For the obtained Test Examples 14 to 24, the stain removal rate was calculated in the same manner as in Test 1. The results are shown in the "Removal Rate" column of Tables 7 and 8. In this test, the following polyoxyethylene-polyoxypropylene block copolymers A to E were used. The compositions of polyoxyethylene-polyoxypropylene block copolymers A to E are as described in the "Type of Copolymer" column of Tables 7 and 8.

[0054] Polyoxyethylene-polyoxypropylene block copolymer A (Copolymer A): Pronon #204 manufactured by NOF Corporation Polyoxyethylene-polyoxypropylene block copolymer B (Copolymer B): Adeka Pluronic L-64 manufactured by ADEKA Corporation Polyoxyethylene-polyoxypropylene block copolymer C (Copolymer C): Pluracare L1220 manufactured by BASF SE Polyoxyethylene-polyoxypropylene block copolymer D (Copolymer D): Unilube 70DP-950B manufactured by NOF Corporation Polyoxyethylene-polyoxypropylene block copolymer E (Copolymer E): Pronon #208 manufactured by NOF Corporation

[0055]

Table 7

[0056]

Table 8

[0057] <Test 3> Oral compositions with different contents of (A) sodium lauryl sulfate and (B) polyoxyethylene-polyoxypropylene block copolymer were prepared, and their stain-removing effects were evaluated.

[0058] (Test Examples 25 to 42) Oral compositions of Test Examples 25 to 42 were prepared according to the formulations shown in Tables 9 to 11. The numerical values in the "Formulation Column" of Tables 9 to 11 are in mass%, and the preparations were made so as to total 100 mass%. For the obtained Test Examples 25 to 42, the stain-removing rate was calculated in the same manner as in Test 1. The results are shown in the "Removal Rate" column of Tables 9 to 11. In this test, the following polyoxyethylene-polyoxypropylene block copolymer B was used.

[0059] Polyoxyethylene-polyoxypropylene block copolymer B (Copolymer B): POE(25)PO(30), EO ratio 50% (Adeka Pluronic L-64 manufactured by ADEKA Corporation)

[0060]

Table 9

[0061]

Table 10

[0062]

Table 11

Claims

1. Sodium lauryl sulfate and, a polyoxyethylene - polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of the polyoxypropylene chain, and the content of the sodium lauryl sulfate is 0.01 to 0.25% by mass, a mouthwash for stain removal, wherein the content of the polyoxyethylene - polyoxypropylene block copolymer is 0.1 to 40% by mass (however, excluding the cases where fired alumina and a peroxide compound are simultaneously contained, where a polyamine compound is simultaneously contained, and where a dicalcium phosphate compound and a peroxide compound containing no metal ions are simultaneously contained).

2. A solid or semi - solid oral composition for stain removal, containing sodium lauryl sulfate and, a polyoxyethylene - polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of the polyoxypropylene chain, and the content of the sodium lauryl sulfate is 1.7 to 10% by mass, an oral composition for stain removal, wherein the content of the polyoxyethylene - polyoxypropylene block copolymer is 0.1 to 40% by mass (however, excluding the cases where a fatty acid dialkanolamide is simultaneously contained, where fired alumina and a peroxide compound are simultaneously contained, where a polyamine compound is simultaneously contained, where a dicalcium phosphate compound and a peroxide compound containing no metal ions are simultaneously contained, where one or more selected from a linear water - soluble polyphosphate represented by the general formula (1) Mn + 2PnO3n + 1 (where M represents Na or K and n≥2) and a cyclic water - soluble polyphosphate represented by the general formula (2) (MPO3)m (where M represents Na or K and m≥3) are simultaneously contained, and where (A) beeswax and / or white beeswax and (B) sodium tetraborate are simultaneously contained).

3. The oral composition for stain removal according to Claim 2, wherein the content of the polyoxyethylene - polyoxypropylene block copolymer is 8 to 15% by mass.

4. A liquid oral composition for stain removal, containing sodium lauryl sulfate and, a polyoxyethylene - polyoxypropylene block copolymer having a structure in which polyoxyethylene chains are bonded to both ends of the polyoxypropylene chain, and The content of the sodium lauryl sulfate is 0.01 to 0.25% by mass, A composition for removing stains in the oral cavity, wherein the content of the polyoxyethylene-polyoxypropylene block copolymer is 0.1 to 40% by mass (however, when simultaneously containing a fatty acid dialkanolamide, when simultaneously containing calcined alumina and a peroxide compound, when simultaneously containing a polyamine compound, when simultaneously containing a dicalcium phosphate compound and a peroxide compound not containing metal ions, when simultaneously containing one or more selected from a linear water-soluble polyphosphate represented by the general formula (1) Mn+2PnO3n+1 (wherein M represents Na or K and n ≧ 2) and a cyclic water-soluble polyphosphate represented by the general formula (2) (MPO3)m (wherein M represents Na or K and m ≧ 3), and when simultaneously containing (A) beeswax and / or white beeswax and (B) sodium tetraborate are excluded).

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