Cosmetic composition containing an antibacterial system with reduced irritation or discomfort to the eyes

Abstract

The cosmetic composition includes an antimicrobial system including an antimicrobial agent including 4-hydroxyacetophenone and one or more additional antimicrobial agents including piroctone olamine. The antimicrobial system can be used in the cosmetic composition, which is a makeup removal composition that is one of an O / W emulsion, a W / O emulsion, a micellar water, a makeup removal wipe, or a two-phase (or multi-phase) composition. The antimicrobial system can be free of, or essentially free of, any one or more of parabens, alcohol, formaldehyde, and formaldehyde-derived compounds. In some specific embodiments, the composition is free of, or essentially free of, parabens, formaldehyde, formaldehyde-derived compounds, pentylene glycol, phenoxyethanol, hexylglycerin, ethylhexylglycerin, octylglycerin, benzylglycerin, 3-heptyl-2,2-propanediol, and 1,2-hexanediol.

Description

Technical Field

[0001] Related Applications This application claims the benefit of U.S. Non-Provisional Patent Application No. 17 / 039,393, filed Sep. 30, 2020, and French Patent Application No. 2012222, filed Nov. 26, 2020, each of which is hereby incorporated by reference in its entirety.

[0002] The present invention relates to makeup removal and cleansing compositions comprising a novel antibacterial system that provides a makeup removal effect while minimizing irritation to the eye and other tissues.

Background Art

[0003] Typically, makeup removal and cleansing are used over the entire face, and some are necessarily used around the eyes. In fact, in addition to long-lasting lip products, there are makeup cleansings specially designed to remove stubborn makeup such as regular or waterproof mascara, eyeliner, eyeshadow, glitter, long-lasting foundation, etc. Such cleansing may require repeated pulling and rubbing on the skin, especially on and around the delicate eye tissues, and may inherently irritate the skin. Furthermore, most makeup removal products contain antibacterial and preservative agents that can approach the eyes during the makeup removal process and, in some cases, accidentally come into contact, resulting in stinging pain and a burning sensation around the eyes.

[0004] Accordingly, there is a need for cosmetic compositions, particularly cleansing and cleansing wipe articles, that provide makeup removal and have the advantage of protection from microbial growth without causing irritation to the eyes or during storage. These compositions and articles desirably exclude antibacterial, preservative, and cleansing components that are irritants such as pentylene glycol, phenoxyethanol, and parabens without sacrificing cleansing and antibacterial efficacy.

[0005] According to the present disclosure, when the new antibacterial system is used in a makeup removing or cleansing composition, unexpectedly, compared with a similarly formulated composition containing a conventional antibacterial system, eye irritation is significantly reduced or does not occur at all.

Summary of the Invention

[0006] The present disclosure, in various embodiments, i.a) an antibacterial agent containing 4-hydroxyacetophenone, and b) at least one additional antibacterial agent containing piroctone olamine, to provide a cosmetic composition containing an antibacterial system.

[0007] According to various embodiments, the cosmetic composition containing the antibacterial system is one of an O / W emulsion, a W / O emulsion, micellar water, a wipe, or a two-phase (or multi-phase) composition. In some specific embodiments, the cosmetic composition is a makeup removing composition that is one of an O / W emulsion, a W / O emulsion, micellar water, a makeup removing wipe, or a two-phase (or multi-phase) composition.

[0008] In some embodiments, the at least one additional antibacterial agent may also include any one or more of antibacterial agents and their salts including the following caprylyl glycol, caprylic hydroxamic acid, chlorphenesin, benzoic acid, salicylic acid, benzyl alcohol, phenethyl alcohol, and benzalkonium chloride.

[0009] In some embodiments, the cosmetic composition does not contain or is essentially free of any one or more of parabens, alcohol, formaldehyde, and formaldehyde-derived compounds. In some specific embodiments, the composition does not contain or is essentially free of parabens, formaldehyde, and formaldehyde-derived compounds.

[0010] In some specific embodiments, the composition does not contain or is essentially free of alcohol containing one or more of ethanol and isopropyl alcohol.

[0011] In some embodiments, the composition does not contain or is essentially free of an antibacterial agent comprising any one or more of pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 3-heptanoyl-2,2-propanediol, and 1,2-hexanediol.

[0012] According to various embodiments, the antibacterial agent comprising 4-hydroxyacetophenone is present in the composition at about 0.2 wt% to about 1 wt%. At least one additional antibacterial agent comprising piroctone olamine (Octopirox), if present, is present in the composition at about 0.05 wt% to about 1.5 wt%. In some specific embodiments, the composition comprises 4-hydroxyacetophenone present in the composition at about 0.25 wt% to about 2 wt%. At least one additional antibacterial agent comprising piroctone olamine, if present, is present in the composition at about 0.05 wt% to about 1.5 wt%.

[0013] According to some embodiments, the present disclosure i.a) an antibacterial agent comprising 4-hydroxyacetophenone, and b) at least one additional antibacterial agent comprising piroctone olamine, and ii. provides a makeup removing composition comprising an aqueous cleansing system.

[0014] According to some embodiments, the present disclosure i.a) an antibacterial agent comprising 4-hydroxyacetophenone, and b) at least one additional antibacterial agent comprising piroctone olamine, and ii.a) one or more lipophilic skin softeners, and b) at least one thickening agent for the aqueous system, and c) one or more humectants, and d) water, and provides a makeup removing composition comprising an aqueous cleansing system.

[0015] According to some embodiments, i. At least one lipophilic skin softening agent is selected from isocetane, C15-19 alkanes, isododecane, undecane, tridecane, isopropyl myristate, dicaprylyl ether, ethylhexyl palmitate, isopropyl palmitate, cetearyl ethylhexanoate, isononyl isononanoate, isopropyl isostearate, diisopropyl sebacate, coco-caprylic / capric acid, diisopropyl adipate, and combinations thereof; ii. At least one thickening agent is selected from acrylate / C10-30 alkyl acrylate crosspolymer, sodium acrylate copolymer, carbomer, xanthan gum, hydroxypropyl guar, sericite silica (faba bean) gum, polyacryloyldimethyltaurine ammonium, acryloyldimethyltaurine ammonium / steareth-25 methacrylate crosspolymer, and polyacrylate crosspolymer-6, and combinations thereof; iii. At least one humectant contains glycerin.

[0016] In various embodiments, the composition may contain two or more of each component, and may further include fragrances, pearlescent agents, silica, proteins, protein hydrolysates, vitamins, panthenol, silicones, odor absorbers, and coloring materials; plant essential oils; fruit extracts (e.g., Pyrus Malus (apple) fruit extract) and Aloe Barbadensis leaf juice powder; citric acid, sodium chloride; neutralizing agents or pH adjusters (e.g., triethylamine (TEA) and sodium hydroxide); and one or more additives selected from combinations thereof.

[0017] In some embodiments, there is provided a cosmetic article comprising a cosmetic composition, the article comprising: a. a water-insoluble substrate comprising a cosmetic wipe, b. impregnating the water-insoluble substrate with the cosmetic composition according to the present disclosure, wherein the cosmetic composition is impregnated onto the water-insoluble substrate at an impregnation rate of 250 wt% to 400 wt% of the cleansing composition based on the weight of the substrate.

[0018] According to various embodiments, the article is formed from synthetic materials or from fibers of natural origin that are naturally biodegradable and sustainably sourced, natural fibers, or recycled or reused natural fibers.

[0019] In some particular embodiments, the article includes non-woven fibers, and the fibers are formed from fibers of natural origin that are naturally biodegradable and sustainably sourced and that include (1) one or a combination of pulp, viscose, lyocell, cellulose acetate, and cotton, (2) natural fibers that include one or a combination of hemp, flax, seaweed, ramie, banana, and pineapple, and (3) recycled or reused fibers that include cotton, and combinations thereof.

[0020] In some embodiments, the present disclosure provides a cosmetic composition that includes an antibacterial system that includes an antibacterial agent that includes 4-hydroxyacetophenone and at least one additional antibacterial agent that includes piroctone olamine; and a skin care system selected from a two-phase aqueous cleansing system, a multi-phase aqueous cleansing system, a single-phase micellar aqueous cleansing system, and a topical composition that is one of a lotion, an essence, a cream, or a mask.

[0021] These and other aspects of the invention are set forth in the appended claims and are described in more detail in the detailed description of the invention.

[0022] This disclosure describes exemplary embodiments in accordance with general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention described herein is broader and not limited to the exemplary embodiments described herein, and the terms used herein have their full ordinary meaning.

[0023] It should be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present disclosure.

BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The term "article" is understood herein to mean a combination of a water-insoluble support and a composition impregnated in the support. This article can particularly be a wipe, but can also have any form including those described below. The water-insoluble substrate is absorbent and strong enough not to decompose during use. Use of the article as defined above for skin or hair care, and / or skin cleansing and / or makeup removal from the skin and / or skin rubbing.

[0025] "Keratin substrate" and "keratin tissue" each include, but are not limited to, skin, hair and nails.

[0026] "Cosmetically acceptable" means a carrier compatible with any keratin substrate.

[0027] In various embodiments, the present disclosure provides an antibacterial system and a makeup removal composition containing the antibacterial system. The antibacterial system includes an antibacterial agent containing 4-hydroxyacetophenone and one or more additional antibacterial agents containing piroctone olamine. In some examples, the antibacterial system can be used in a skin care system selected from a two-phase aqueous cleansing system, a multi-phase aqueous cleansing system, a single-phase micellar water aqueous cleansing system, and a topical composition which is one of a lotion, essence, cream or mask. In some specific examples, the antibacterial system can be used in a makeup removal composition which is one of an O / W emulsion, a W / O emulsion, micellar water or a two-phase (or multi-phase) composition. In some embodiments, the composition is used in a makeup removal wipe.

[0028] In various embodiments, the antibacterial system may not contain or may be essentially free of any one or more of parabens, alcohols, formaldehyde, and formaldehyde-derived compounds. In some specific embodiments, the composition does not contain or is essentially free of parabens, formaldehyde, and formaldehyde-derived compounds. In some specific embodiments, the composition does not contain or is essentially free of one or more of pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 1,3-propanediol, 3-heptanoyl-2,2-propanediol, and 1,2-hexanediol. In some specific embodiments, the composition does not contain or is essentially free of each of pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 1,3-propanediol, 3-heptanoyl-2,2-propanediol, and 1,2-hexanediol. In some embodiments, the composition does not contain or is essentially free of all alcohols. In some specific embodiments, the composition does not contain or is essentially free of alcohols containing one or more of ethanol and isopropyl alcohol.

[0029] In various embodiments, the composition can include two or more of the respective components and can further include one or more additives including, among other cosmetically acceptable additives, a humectant, a preservative, a fragrance, an active agent, and a pH adjuster.

[0030] Through consumer evaluation of MUR effectiveness, the compositions according to the present disclosure showed makeup removal performance consistent with the comparative compositions and showed significantly improved performance with respect to eye irritation.

[0031] In some embodiments, the present disclosure provides an antimicrobial and makeup removal composition that has penetrated a cosmetic application article. The article can be formed of synthetic materials such as PET (polyethylene terephthalate or polyester) and PP (polypropylene), which can be used alone or in combination with natural-based materials. And in some embodiments, the article is formed from a sustainable and biodegradable substrate from sources such as (1) fibrous non-wovens of natural origin such as pulp, viscose, lyocell, cellulose acetate, cotton, (2) fibrous non-wovens of natural fibers such as hemp, linen, seaweed, ramie, banana, pineapple, and (3) recycled or reused fibrous non-wovens such as cotton.

[0032] Many conventional cosmetic articles such as wipes are formed of fossil fuel-based polymer materials such as PET (polyethylene terephthalate or polyester) and PP (polypropylene), which can be used alone or in combination with natural-based materials. Such synthetic substrates are desirable because they have a relatively low manufacturing cost and can provide excellent tensile strength, but they do not essentially decompose and thus have an adverse impact on the environment. There is a growing interest in sustainability in the cosmetics industry, and there is a need for cosmetic articles that utilize solid substrates sourced from (1) fibrous non-wovens of natural origin such as pulp, viscose, lyocell, cellulose acetate, cotton, (2) fibrous non-wovens of natural fibers such as hemp, linen, seaweed, ramie, banana, pineapple, and (3) recycled or reused fibrous non-wovens such as cotton. As used herein, the term "fiber of natural origin" refers to a fiber material formed by a chemical treatment that gives a derivative based on a natural fiber. "Natural fiber" means the non-derived form of a natural fiber. "Recycled / reused" means a natural fiber recycled from an article formed of such fibers.

[0033] In some embodiments, the articles herein are formed from a substrate that is obtained from a sustainable source and is biodegradable. In some particular embodiments, these materials are selected from natural origin fibers formed into a nonwoven fabric using fibers such as pulp, viscose, lyocell, cellulose acetate, and cotton. And in a particular embodiment, the substrate used to form the cosmetic article is a nonwoven fabric of lyocell. According to these embodiments that include fibers that are naturally biodegradable and sustainably sourced, an obvious advantage realized is the opportunity to reduce the environmental impact. Other advantages may also be obtained by using a sustainable and biodegradable substrate. As further described herein, articles using a sustainable and biodegradable substrate, particularly a lyocell nonwoven fabric, exhibit certain mechanical, texture, and absorbent properties.

[0034] The articles according to the present disclosure are soft to the touch. It is comfortable during application to the skin and exhibits the advantage of having a nourishing effect due to the presence of the oil phase. When used to wash the skin or remove makeup from the skin, the articles according to the present disclosure may, in some cases, remain applied for a time sufficient for the cosmetic product to dissolve in the impregnated composition of the article, pass over the skin, and then the skin is wiped. The skin can also optionally be rinsed thereafter. The articles according to the present invention are preferably cosmetic articles suitable for the care and / or treatment of the skin of the face, body or hands, and for washing the skin of the face and / or body or removing makeup from the skin of the face and / or body. It can also be used for hair care and removing makeup from the eyes.

[0035] An article according to the present disclosure can have any form suitable for a desired purpose. It can generally be rectangular, square, or a single layer, multiple layers, and can constitute a wipe having other shapes that can be folded or unfolded. The article can also be in the form of gloves, mittens, or other forms suitable for actual use on the face or body, such as a face form with holes in the eye, nose, and / or mouth areas, or a form of a finger sack for applying makeup remover when removing makeup from eyelashes, or a double-sided circular form that can include two sides impregnated with different compositions. The article can also include a rough surface that allows for exfoliation (rubbing) of the skin.

[0036] In an exemplary embodiment, a composition containing the antibacterial system of the invention according to the present disclosure can be in the form of a makeup removing composition containing one or more lipophilic skin softeners, one or more volatile silicone compounds, at least one thickener for aqueous systems, as well as one or more wetting agents and water. Of course, in other embodiments, it will be understood that the antibacterial system of the invention according to the present disclosure can generally be provided in a composition in the form of one of an O / W emulsion, a W / O emulsion, micellar water, a makeup removing wipe, or a two-phase (or multi-phase) composition. Thus, according to the teachings of the art regarding the selection of components for various cosmetic compositions, particularly makeup removing compositions, the antibacterial system can be incorporated and replace conventional antibacterial systems in the art. And in particular, such compositions do not contain, or are essentially free of, any one or more of parabens, surfactants, alcohols, formaldehyde, and formaldehyde-derived compounds. And in some embodiments, the composition does not contain, or is essentially free of, an antibacterial agent containing any one or more of pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 3-heptanoyl-2,2-propanediol, and 1,2-hexanediol.

[0037] Lipophilic skin softener According to the present disclosure, the composition according to the present disclosure can include one or more lipophilic skin softeners.

[0038] The lipophilic skin softener can be selected from branched or straight-chain liquid alkanes having a carbon chain length of C11 to C20. In various embodiments, the liquid alkane can be selected from those having a carbon chain length of C11 to C20. The liquid alkane can be selected from those having one of the carbon chain lengths of C11 to C20, or C15 to C19, or C11, C12, C13, C14, C15, C16, C17, C18 to C19. In some specific embodiments, suitable liquid alkanes that can be used according to the present disclosure include hydrocarbon oils containing 8 to 16 carbon atoms, particularly branched C8 to C16 alkanes such as C8 to C16 isoparaffins. In some exemplary embodiments, such liquid alkanes can be selected from isoparaffins such as isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane, and isohexadecane.

[0039] In some embodiments, at least one lipophilic skin softener includes one or more of isohexadecane, C15-19 alkanes, isododecane, undecane, tridecane, and combinations thereof. In some embodiments, at least one lipophilic skin softener includes isohexadecane.

[0040] The lipophilic skin softener can be selected from polar skin softeners. The skin softener is an oil phase component selected from esters, triglycerides, ethers, carbonates, alcohols, oils, butters, fatty acids, and combinations thereof. In various embodiments, the polar skin softener can be selected from those having a molecular weight of 400 g / mol or less. More generally, the polar skin softener can have a molecular weight in the range of about 50 g / mol to about 350 g / mol.

[0041] In some embodiments, suitable polar skin softeners that can be used in accordance with the present disclosure include those derived from C12 - C50 fatty acids, preferably C16 - C22 saturated fatty acids, and monohydric alcohols. In some embodiments, such esters can be selected from isopropyl myristate, methyl palmitate, isopropyl laurate, isopropyl palmitate, ethylhexyl palmitate, ethylhexyl laurate, ethylhexyl oleate, ethylhexyl isononanoate, myristyl myristate, 2 - ethylhexyl caprate / caprylate (or octyl caprate / caprylate), 2 - ethylhexyl palmitate, isostearyl neopentanoate, isononyl isononanoate, hexyl laurate, esters of lactic acid and aliphatic alcohols containing 12 or 13 carbon atoms, dicaprylyl carbonate, and mixtures thereof.

[0042] In some embodiments, at least one lipophilic skin softener includes one of isopropyl myristate, dicaprylyl ether, ethylhexyl palmitate, isopropyl palmitate, cetearyl ethylhexanoate, isononyl isononanoate, isopropyl isostearate, diisopropyl sebacate, caprylic / capric cocoglycerides, diisopropyl adipate, and combinations thereof. In some particular embodiments, at least one lipophilic skin softener includes isopropyl myristate.

[0043] In some embodiments, at least one lipophilic skin softener includes dimethicone, cyclopentasiloxane, and / or other silicone skin softeners.

[0044] In some particular embodiments, at least one lipophilic skin softener includes each of isododecane, isopropyl myristate, dimethicone, cyclopentasiloxane, and / or other silicone skin softeners.

[0045] The amount of each of at least one or more lipophilic skin softeners that may be present in the composition is provided in the range of about 1 wt% to about 12 wt%, or about 3 wt% to about 11 wt%, or about 5 wt% to about 10 wt%, or any suitable combination, partial combination, range or partial range thereof, based on the weight of the composition. However, those skilled in the art will understand that other ranges are within the scope of the present invention.

[0046] Accordingly, each of the at least one or more lipophilic skin softeners in the composition may be present at about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 to about 12 weight percent, including increments and ranges therein and therebetween, based on the total weight of the composition.

[0047] Thickener According to the present disclosure, a composition according to the present disclosure can include at least one thickener.

[0048] In some embodiments, the at least one thickener can be selected from one or more of natural gums and synthetic polymers such as starches (corn, rice, tapioca, potato), gums (xanthan, carrageenan, gellan, sclerotium).

[0049] In some embodiments, the composition includes two or more thickeners. In some such embodiments, the composition includes one or both of the polymeric thickeners acrylate / C10-30 alkyl acrylate crosspolymer and sodium acrylate copolymer, and optionally one or more additional polymeric thickeners.

[0050] The amount of each of the at least one thickener is present in the composition in the range of about 0.01 wt% to about 5 wt%, or about 0.01 wt% to about 3 wt%, or about 0.05 wt% to about 2.5 wt%, or any suitable combination, partial combination, range or partial range thereof, based on the weight of the composition. However, those skilled in the art will understand that other ranges are within the scope of the present invention.

[0051] In some embodiments, the total amount of the thickener in the composition is present in an amount of about 0.01 wt% to about 5 wt%, or about 1.0 wt% to about 3 wt%, or about 2 wt% to about 2.55 wt%, or any suitable combination, sub-combination, range or sub-range thereof, based on the weight of the composition. However, those skilled in the art will understand that other ranges are within the scope of the present invention.

[0052] Thus, when one or more thickeners are present, it is present in an amount of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.5, 4.0, 4.5 to about 5.0 percent, including increments and ranges therein and therebetween, based on the total weight of the composition.

[0053] Solvent / Water According to various embodiments, water is present in the composition in an amount of about 40 wt% to about 90 wt%, or about 55 wt% to about 85 wt%, or about 60 wt% to about 75 wt%, or about 65 wt% to about 70 wt%, or any suitable combination, sub-combination, range or sub-range thereof, based on the weight of the composition. However, those skilled in the art will understand that other ranges are within the scope of the present invention. Thus, water is present in an amount of about 40, 45, 50, 55, 60, 65, 70, 75, 80, 85 to about 90 weight percent, including increments and ranges therein and therebetween, based on the total weight of the composition.

[0054] The water used can be sterile demineralized water and / or aromatic distilled water (e.g., rose water, geranium water, chamomile water or lime water), and / or natural thermal water or mineral water (e.g., water from Vittel, water from the Vichy basin, water from Uriage, water from La Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais-les-Bains, water from Neris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizieres, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from Eaux Bonnes, water from Rochefort, water from Saint Christau, water from Les Fumades, water from Tercis-les-Bains or water from Avene). The aqueous phase may also include reconstituted thermal water, i.e., water containing trace elements such as zinc, copper, magnesium that reconstitute the properties of thermal water.

[0055] The pH of the composition is generally between 2 and 12, although not limited, and in some embodiments is one of between 3 and 11, between 5 and 9, and between 6 and 8, and in some embodiments is 7. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the composition, such as ammonia, or a primary, secondary or tertiary (poly)amine (e.g., monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine), or by adding an inorganic or organic acid, preferably a carboxylic acid, such as citric acid.

[0056] In some embodiments, the composition can contain one or more additional solvents, such as monohydric C1-C8 alcohols such as ethanol, propanol, butanol, isopropanol, isobutanol and benzyl alcohol and phenylethyl alcohol.

[0057] In some embodiments, the composition does not contain or is essentially free of any and all alcohols. In some specific embodiments, the composition does not contain or is essentially free of alcohols including one or more of ethanol and isopropyl alcohol.

[0058] Wetting agent / hydrating agent According to the present disclosure, another wetting agent may be present in the composition. In some embodiments, the wetting agent includes, for example, polyols including glycerin, glycerol, butylene glycol, propylene glycol, isoprene glycol, dipropylene glycol, hexylene glycol, and polyethylene glycol; monoethylene glycol, diethylene glycol, triethylene glycol, diethylene glycol, hexylene glycol, glycol ethers (for example, monopropyrene, dipropylene, and tripropylene glycol alkyl (C1-C4) ethers), squalane, triacetin, saccharides (for example, glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol), pyrrolidone carboxylic acid, lactic acid, lithium chloride, acetamide MEA, sodium lactate, urea, dicyanamide, hyaluronic acid, aloe vera, honey, and one or more of seaweed extracts.

[0059] In some embodiments, the composition includes a wetting agent including glycerin.

[0060] According to various embodiments, the amount of the wetting agent is present in the composition in the range of about 1 wt% to about 15 wt%, or about 2 wt% to about 12 wt%, or about 3 wt% to about 7 wt%, or about 4 wt% to about 5 wt%, or any suitable combination, partial combination, range or partial range thereof, based on the weight of the composition. However, those skilled in the art will understand that other ranges are within the scope of the present invention.

[0061] Accordingly, any one or combination of the humectants can be present in an amount of about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 to about 15 weight percent, including increments and ranges therein and therebetween, based on the total weight of the composition.

[0062] Any additive The composition can also include at least one additive, fragrance, pearlescent agent, silica, protein, protein hydrolyzate, vitamin, panthenol, silicone, odor absorbent, and coloring material used in the cosmetic field that do not affect the properties of the composition according to the present invention; essential oils; fruit extracts (e.g., Pyrus Malus (apple) fruit extract) and Aloe Barbadensis leaf juice powder; citric acid, sodium chloride; neutralizing or pH adjusting agents (e.g., triethylamine (TEA) and sodium hydroxide); and additives selected from combinations thereof.

[0063] Although the optional active additives are shown by way of example, it will be understood that any other components suitable for cosmetic use known in the art can be used. Although the optional additives are shown by way of example, it will be understood that any other components suitable for cosmetic use known in the art can be used.

[0064] According to various embodiments, the amount of one or more active substances and additives present alone or in combination in the composition can be about 0.001 weight % to about 20 weight %, or about 0.005% to about 0.01%, or about 0.01% to about 0.1%, or about 0.15% to about 5%, or about 0.40% to about 4%, or about 0.5% to about 2.5%, or about 1% to about 2%, or any suitable combination, partial combination, range or partial range thereof, based on the total weight of the composition, and can be present in the compositions according to the present disclosure.

[0065] Accordingly, any one or combination of the active substance and the additive can be present based on the total weight of the composition, and each one or combination is present in an amount of about 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges therein and therebetween.

[0066] Substrate According to various embodiments, in some embodiments, an article is provided that includes a solid substrate infused with the antibacterial system of the present invention, in the form of a makeup removing composition. The article is formed from a synthetic material or from natural, natural-derived, regenerated, or recycled natural fibers that are biodegradable and sustainably sourced.

[0067] According to some embodiments, the substrate is a non-woven material. A general description of non-woven materials is provided in Riedel “Nonwoven Bonding Methods and Materials”, Nonwoven World (1987). These substrates are obtained according to the usual methods of non-woven material preparation techniques. When the substrate is a non-woven material, those made from a strong non-woven fabric that does not pill, does not fall apart when touching the skin, and does not fuzz can be used. In particular, for removing eye makeup, at least one side needs to be absorbent and soft. Suitable non-woven materials include, for example, Ultraloft 15285-01, Ultraloft 182-008, Ultraloft 182-010, and Ultraloft 182-016 manufactured by BBA, those sold under the names of Vilmed M1519 Blau, Vilmed M1550N, and 112-132-3 manufactured by Freudenberg, those sold under the name of Norafin 11601-010B manufactured by Jacob Holm Industries, flock non-woven fabrics sold under the names of Univel 109 and Univel 119 manufactured by Uni Flockage, and those made of viscose / PLA supplied by Sandler.

[0068] According to some embodiments including the article, a water-insoluble substrate is used. The water-insoluble substrate can include one or more layers and can be selected from the group consisting of a woven material, a non-woven material, a foam, a sponge, and a stuffing cotton as a sheet, a sphere, or a film. In particular, it can be a non-woven substrate based on fibers of natural origin (fibers made of linen, wool, cotton, silk, viscose, bamboo) or fibers of synthetic origin (cellulose derivatives, polyvinyl derivatives, polyesters such as poly(ethylene terephthalate), polyolefins such as polyethylene (PET) or polypropylene, polyamides such as nylon, or acrylic derivatives) and mixtures thereof such as viscose / PET, polylactic acid (PLA), or viscose / polylactic acid (viscose / PLA).

[0069] According to one embodiment, the substrate is a nonwoven material made of hydroentangled viscose or a nonwoven material made of a viscose / microviscose blend. In some particular embodiments, the article comprises nonwoven fibers, the fibers being formed from natural, biodegradable, sustainably sourced fibers selected from (1) naturally occurring fibers including one or a combination of pulp, viscose, lyocell, cellulose acetate, and cotton; (2) natural fibers including one or a combination of hemp, flax, seaweed, ramie, banana, and pineapple; and (3) regenerated or recycled fibers including cotton, and combinations thereof. According to one embodiment, the substrate is a nonwoven material formed from a biodegradable material such as lyocell.

[0070] According to some embodiments, the article can include one or more layers with the same or different properties, including elasticity, flexibility, and other properties suitable for the desired application. The substrate can include two portions with different elastic properties, as described in WO-A-99 / 13861, a single layer with different densities, as described in WO-A-99 / 25318, or two layers with different textures, as described in WO-A-98 / 18441. According to some embodiments, when the article is used on the body, the article can include at least one roughened surface to allow simultaneous massaging or rubbing of the skin.

[0071] According to various embodiments, the article can have any size and any shape suitable for a desired purpose. 2 and 0.1m 2 Between or 0.01m 2 and 0.05m 2 The weight of the substrate can range between 30 gsm and 200 gsm (grams per square meter), or between 40 gsm and 60 gsm.

[0072] According to various embodiments, the impregnation degree of the composition onto the substrate is generally in the range of 100% to 1000% of the weight of the substrate, in some embodiments about 150% to about 700%, or about 250% to about 400%. Techniques for impregnating the substrate with the composition are well-known and can be applied to the present invention in its entirety. Generally, the impregnating composition is heated and added to the substrate by one or more techniques including dipping, coating, spraying, and the like.

Example

[0073] Example 1: Raw Materials

Table 1

[0074] Example 2: Invention Example: Various representative embodiments of the composition of the present invention are illustrated herein. In some cases, the composition is antibacterial. In some embodiments, the composition is a makeup remover in the form of one of an O / W emulsion, a W / O emulsion, or in micellar water, in a makeup removing wipe, or in a two-phase (or multi-phase) makeup removing composition. In some specific exemplary embodiments, the composition is a makeup remover comprising an antibacterial composition.

[0075] Exemplary embodiments of the composition of the present invention in the form of a cleansing and makeup removing composition (not penetrated into the substrate) according to the present disclosure are shown in Table 2.

Table 2

[0076] Example 1 and Example 2 of the present invention each contain an antibacterial system that does not contain (or is essentially free of) phenoxyethanol and pentylene glycol, and each contains the antibacterial agents 4-hydroxyacetophenone and piroctone olamine, and are essentially the same composition as a commercially available product sold under the trade name DERMABLEND MAKEUP DISSOLVER, except for the above. As reported in more detail in connection with the consumer tests, the above table shows that each of the two compositions of the present invention is substantially or entirely free of irritation, particularly when compared to the specifically tested comparative compositions and to the overall eye irritation of the category of comparative subjects containing a representative antibacterial system.

[0077] Example 3: Comparative Example Exemplary embodiments of comparative examples in the form of cleansing and makeup removing compositions (not penetrated into the substrate) according to the present disclosure are shown in Table 3.

Table 3

[0078] Comparative Example 1 is a commercially available product sold under the trade name DERMABLEND MAKEUP DISSOLVER and contains the antibacterial agents phenoxyethanol and caprylyl glycol (representatives of typical antibacterial systems used in many cosmetics in the art at the time of this application). Comparative Example 2 is the same as Comparative Example 1, except that phenoxyethanol has been replaced by the antibacterial 4-hydroxyacetophenone. Comparative Example 3 is the same as Comparative Example 1, except that the composition also contains the antibacterial ethylhexylglycerin. Comparative Example 4 is the same as Comparative Example 2, except that hydroxyacetophenone has been replaced by pentylene glycol. As reported in more detail in connection with the consumer tests, the above table shows that each of the four comparative examples was associated with moderate to high irritation.

[0079] Example 4: Antibacterial Agent Challenge Experiment As shown in the following table, experiments were conducted using each of the compositions of the present invention and the comparative compositions, and their antibacterial effects against a series of microorganisms were evaluated. The results are shown in Tables 4 to 11. [Table 4] [Table 5] [Table 6] [Table 7] [Table 8] [Table 9] [Table 10] [Table 11]

[0080] Example 5: Consumer Survey on the Effectiveness of Eye Irritation and Makeup Removal (MUR) A consumer survey was conducted to evaluate the eye irritation and / or discomfort and the effectiveness of MUR of the compositions of the present invention and the comparative compositions. Samples of Example 1 of the present invention, Comparative Example 1, and Comparative Example 4 were provided to a cohort of 10 consumers. The consumers used the products daily for two weeks and then participated in the survey after two weeks of use. The eye irritation / discomfort and the effectiveness of MUR were reported using a rating scale of 1 to 5 as follows.

[0081] Eye irritation / discomfort. Scale 1 - 5: 1 = No stinging pain or discomfort, 5 = Very stinging & uncomfortable

[0082] Effectiveness of MUR. Scale 1 - 5: 1 = no removal or difficult to remove, 5 = easy to completely remove

[0083] Table 12 shows the results indicating generally comparable (with respect to the effectiveness of MUR) and excellent performance (with respect to eye irritation) of the compositions of the present invention as compared to the comparative compositions. (Note: If described, the subject * stopped using Comparative Composition 1 because the eyes stung after a single application). [Table 12]

[0084] Example 6: Invention examples and comparative examples of makeup removing wipe products. Table 13 shows the eye irritation and MUR tests of the MUR liquid formulations of the invention examples and comparative examples, and the corresponding MUR wipes. All wipes were prepared by impregnating a lyocell nonwoven substrate with the liquid formulation at an impregnation rate of 320%. The results clearly showed significantly reduced eye irritation and excellent microchallenge results for Invention Example 3 as compared to the comparative examples. [Table 13 - 1] [Table 13 - 2]

[0085] Although the present disclosure has been described with reference to preferred embodiments, those skilled in the art will understand that various changes may be made without departing from the scope of the present disclosure, and equivalents may replace its elements. Further, many modifications may be made to adapt a particular situation or material to the teachings of the present disclosure without departing from the essential scope thereof. Accordingly, the present disclosure is not limited to the particular embodiments disclosed as the best mode contemplated for carrying out the present disclosure, but is intended to include all embodiments falling within the scope of the appended claims.

[0086] As used herein, the articles “a” and “an,” when applied to any feature in the embodiments of the present disclosure described herein and in the claims, mean one or more. The use of “a” and “an” is not intended to limit the meaning to a single feature unless specifically stated to be limiting. The article “the” preceding a singular or plural noun or noun phrase indicates a specified function and may have a singular or plural meaning depending on the context in which it is used. The adjective “any” means any one, some, or all, without distinction, of any amount.

[0087] As used herein, “at least one” means one or more and thus includes individual components and mixtures / combinations thereof.

[0088] The transitional terms "comprising," "consisting essentially of," and "consisting of" in their original and modified forms, when used in the appended claims, define the claims with respect to whether additional claim elements or steps, if any, not recited are excluded from the scope of the claim(s). The term "comprising" is intended to be inclusive or open-ended and does not exclude additional unrecited elements, methods, steps, or materials. The term "consisting of" excludes elements, steps, or materials other than those specified in the claim, and in the latter case, excludes impurities ordinarily associated with the specified material(s). The term "consisting essentially of" limits the claim to those things that do not materially affect the basic and novel characteristics of the claimed disclosure, including the specified element(s), step(s), or material(s). All materials and methods described herein that embody the present disclosure can be more specifically defined in alternative embodiments by any of the transitional terms "comprising," "consisting essentially of," and "consisting of."

[0089] The terms "free of" and "lacking" indicate that a measurable excluded substance is definitely not present in the composition and is typically 0 wt% based on the total weight of the composition. The term "essentially free of" means that it is preferred that no excluded substances are present in the composition, but very small amounts of excluded substances may be included in the compositions of the present invention, provided that these amounts do not materially affect the effective properties of the composition. In particular, "essentially free of" means that the excluded substance may be present in the composition in an amount of less than about 0.1 wt% based on the total weight of the composition.

[0091] Unless otherwise indicated, all percentages and ratios are calculated by weight. All percentages are calculated based on the entire composition unless otherwise indicated. Generally, unless otherwise expressly stated herein, the "weight" or "amount" used herein with respect to the percentage amount of a component refers to the amount of the raw material containing the component, and the raw material may be described herein as containing less than 100% and up to 100% of the activity of the component. Thus, the weight percentage of the active substance in the composition is expressed as the amount of the raw material containing the active substance used, and may or may not reflect the final percentage of the active substance, which depends on the weight percentage of the active substance in the raw material.

[0092] All ranges and amounts shown herein are intended to include sub-ranges and amounts using any of the disclosed points as endpoints. Thus, a range of "1% to 10%, such as 2% to 8%, such as 3% to 5%" is intended to encompass ranges such as "1% to 8%", "1% to 5%", "2% to 10%", etc. 。More It should be understood that when the amount of a component is indicated, unless otherwise specified, it is intended to represent the amount of the active substance.

[0093] Although the numerical ranges and parameters indicating the broad scope of the present disclosure are approximations, the numerical values described in specific examples are reported as accurately as possible unless otherwise indicated. However, any numerical value inherently contains certain errors that necessarily result from the standard deviation recognized during each of their test measurements. The following examples serve to illustrate embodiments of the present disclosure but are not intended to be limiting in nature.

[0094] All publications and patent applications cited herein are hereby incorporated by reference in their entirety, as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference, and for all purposes. In the event of any conflict between the present disclosure and a publication or patent application incorporated herein by reference, the present disclosure shall control.

Claims

1. i. An antibacterial agent containing 4-hydroxyacetophenone, and ii. At least one additional antibacterial agent containing piroctone olamine A cosmetic composition comprising an antibacterial system, wherein The cosmetic composition is a makeup removing composition, Cosmetic composition.

2. The cosmetic composition according to claim 1, which is one of an oil-in-water emulsion, a reverse (water-in-oil) emulsion, micellar water, and a multiphase composition.

3. The at least one additional antibacterial agent contains one or more of antibacterial agents selected from caprylyl glycol, caprylic hydroxamic acid, chlorphenesin, benzoic acid, salicylic acid, benzyl alcohol, phenethyl alcohol, benzalkonium chloride, its salts, and combinations thereof. The cosmetic composition according to claim 1.

4. The cosmetic composition according to claim 1, which does not contain any one or more of pentylene glycol, parabens, ethanol, formaldehyde, and formaldehyde-derived compounds.

5. The cosmetic composition according to claim 1, which does not contain parabens, formaldehyde, and formaldehyde-derived compounds.

6. The cosmetic composition according to claim 1, which does not contain an alcohol containing one or more of ethanol and isopropyl alcohol.

7. The cosmetic composition according to claim 1, which does not contain an antibacterial agent containing any one or more of pentylene glycol, phenoxyethanol, hexyl glycerin, ethylhexyl glycerin, octyl glycerin, benzyl glycerin, 3-heptanoyl-2,2-propanediol, and 1,2-hexanediol.

8. The antibacterial agent containing 4-hydroxyacetophenone is present in the cosmetic composition at 0.2% to 1% by weight, and the at least one additional antibacterial agent containing piroctone olamine is present in the cosmetic composition at 0.05% to 1.5% by weight. The cosmetic composition according to claim 1.

9. The cosmetic composition contains 4-hydroxyacetophenone present in the cosmetic composition at 0.25% to 2% by weight, and the at least one additional antibacterial agent containing piroctone olamine is present in the cosmetic composition at 0.05% to 1.5% by weight. The cosmetic composition according to claim 1.

10. a.i. An antibacterial agent containing 4-hydroxyacetophenone, and ii. At least one additional antibacterial agent containing piroctone olamine An antibacterial system containing, and b. An aqueous cleansing system A makeup removing composition containing.

11. The aqueous cleansing system is i. One or more lipophilic skin softeners, ii. At least one thickener for the aqueous system, iii. One or more wetting agents, and iv. Water The makeup removing composition according to claim 10, containing.

12. The at least one lipophilic skin softener is selected from isododecane, C15-19 alkane, isododecane, undecane, tridecane, isopropyl myristate, dicaprylyl ether, ethylhexyl palmitate, isopropyl palmitate, cetearyl ethylhexanoate, isononyl isononanoate, isopropyl isostearate, dipropyl sebacate, coco-caprylic / capric acid, dipropyl adipate, dimethicone, cyclopentasiloxane, and combinations thereof. The makeup removing composition according to claim 11.

13. The at least one thickener is selected from acrylate / C10-30 alkyl acrylate crosspolymer, sodium acrylate copolymer, carbomer, xanthan gum, hydroxypropyl guar, sericite silica (carob) gum, polyacryloyldimethyltaurine ammonium, acryloyldimethyltaurine ammonium / steareth-25 methacrylate crosspolymer, polyacrylate crosspolymer-6, and combinations thereof. The makeup removing composition according to claim 11.

14. The at least one wetting agent contains glycerin. The makeup removing composition according to claim 11.

15. The makeup removing composition according to claim 11, further containing one or more additives selected from the group consisting of fragrances, pearlescent agents, silica, proteins, protein hydrolysates, vitamins, panthenol, silicones, odor absorbers, coloring materials, essential oils, fruit extracts, citric acid, sodium chloride, neutralizing agents, and combinations thereof.

16. a. A water-insoluble substrate containing a cosmetic wipe, and b. A cleansing composition impregnated in the water-insoluble substrate, i. An antibacterial agent containing 4-hydroxyacetophenone, and ii. At least one additional antibacterial agent containing piroctone olamine A cleansing composition comprising an antibacterial system. A makeup removing and cleansing article.

17. The makeup removing and cleansing article according to claim 16, wherein the cleansing composition is impregnated into the water-insoluble substrate at an impregnation rate of 250% to 400% by weight of the cleansing composition with respect to the weight of the water-insoluble substrate.

18. The makeup removing and cleansing article according to claim 16, which is a makeup removing wipe containing non-woven fibers, and the non-woven fibers are (1) fibers of natural origin including one or a combination of pulp, viscose, lyocell, cellulose acetate, and cotton, (2) natural fibers including one or a combination of hemp, flax, seaweed, ramie, banana, and pineapple, and (3) recycled or reused fibers including cotton, and are formed from natural biodegradable and sustainably sourced fibers selected from the group consisting of these combinations.

19. a. i. An antibacterial agent containing 4-hydroxyacetophenone, and ii. At least one additional antibacterial agent containing piroctone olamine An antibacterial system, and b. i. A two-phase aqueous cleansing system, ii. A multi-phase aqueous cleansing system, iii. A single-phase micellar aqueous cleansing system, and iv. A topical composition which is one of a lotion, essence, cream or mask A skin care system selected from A makeup removing composition.

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