Composition for forming artificial skin and method of using same

Abstract

Provided is a composition for forming artificial skin with which it is possible to reduce cross-linking time while maintaining excellent application performance and film performance.　The composition for forming artificial skin according to the present disclosure includes a first agent and a second agent. The first agent includes: (a) a polymer A composed of one or more organopolysiloxanes having, intramolecularly, at least two carbon-carbon double bonds or at least one carbon-carbon triple bond; (b) a polymer B composed of one or more organopolysiloxanes having, intramolecularly, at least two Si-H units; and (c) a silicone having a viscosity of 1.5 mPa·s or less at 25°C. The second agent includes a catalyst that promotes cross-linking of the polymer A and the polymer B.

Description

[Technical Field]

[0001] The present disclosure relates to a composition for forming artificial skin and a method for using the same. [Background technology]

[0002] In recent years, technology relating to artificial skin that can be used for damaged skin and the like has become known.

[0003] Patent Document 1 discloses a method for producing a fiber-containing coating on the surface of human skin or nails, which method includes electrostatically spraying composition A directly onto the skin or nails, wherein composition A contains (a) one or more volatile substances selected from alcohols and ketones, (b) a water-insoluble polymer for forming fibers, and (c) 0.2% by mass or more and 25% by mass or less of water, and the mass ratio (b / c) of component (b) to component (c) is 0.4 or more and 50 or less.

[0004] Patent Document 2 discloses a body correcting formulation for application to the skin, comprising: (a) a reactive reinforcing component; and (b) a crosslinking component; wherein the crosslinking component catalyzes crosslinking of the reactive reinforcing component in situ, resulting in the formation of a body correcting film on the skin, and the film has the appearance of natural skin when applied to the body. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 2018-177803 [Patent Document 2] Special Publication No. 2013-536861 Summary of the Invention [Problem to be solved by the invention]

[0006] The coating described in Patent Document 1 is a special coating containing fibers formed by electrostatic spraying, and forming such a coating requires the use of a dedicated, expensive electrostatic spray device. Furthermore, forming a desired coating in a desired location using the electrostatic spray device requires a certain level of skill.

[0007] On the other hand, the coating described in Patent Document 2 can be formed by spreading it on the skin of the body without using an electrostatic spray device as described in Patent Document 1. However, since such a coating requires a relatively long time to crosslink, it has been desired to shorten the crosslinking time.

[0008] Therefore, an object of the present disclosure is to provide a composition for forming artificial skin that can shorten the crosslinking time while maintaining excellent application and film-forming properties. [Means for solving the problem]

[0009] <Aspect 1> A composition for forming artificial skin, comprising a first agent and a second agent, the first agent comprises: (a) a polymer A composed of one or more organopolysiloxanes having at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule; (b) a polymer B composed of one or more organopolysiloxanes having at least two Si-H units in the molecule; and (c) a silicone having a viscosity at 25°C of 1.5 mPa s or less; the second agent contains a catalyst that promotes crosslinking of the polymer A and the polymer B; composition. <Aspect 2> 2. The composition according to aspect 1, wherein the silicone is polydimethylsiloxane having 3 to 5 silicon atoms. <Aspect 3> 3. The composition of claim 1 or 2, wherein Polymer A is at least one selected from vinyl-terminated polydimethylsiloxane, vinyl-terminated diphenylsiloxane-dimethylsiloxane copolymer, vinyl-terminated polyphenylmethylsiloxane, vinylphenylmethyl-terminated vinylphenylsiloxane-phenylmethylsiloxane copolymer, vinyl-terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymer, vinyl-terminated diethylsiloxane-dimethylsiloxane copolymer, vinylmethylsiloxane-dimethylsiloxane copolymer, trimethylsiloxy-terminated vinylmethylsiloxane-dimethylsiloxane copolymer, silanol-terminated vinylmethylsiloxane-dimethylsiloxane copolymer, vinylmethylsiloxane homopolymer, vinyl T-structure polymer, monovinyl-terminated polydimethylsiloxane, vinylmethylsiloxane terpolymer, and vinylmethoxysilane homopolymer. <Aspect 4> Aspect 4. The composition of any one of Aspects 1 to 3, wherein Polymer B is at least one selected from hydride-terminated polydimethylsiloxane, hydride-terminated polyphenyl-(dimethylhydrosiloxy)siloxane, hydride-terminated methylhydrosiloxane-phenylmethylsiloxane copolymer, trimethylsiloxy-terminated methylhydrosiloxane-dimethylsiloxane copolymer, polymethylhydrosiloxane, trimethylsiloxy-terminated polyethylhydrosiloxane, triethylsiloxane, methylhydrosiloxane-phenyloctylmethylsiloxane copolymer, and methylhydrosiloxane-phenyloctylmethylsiloxane terpolymer. <Aspect 5> Aspect 5. The composition according to any one of aspects 1 to 4, wherein the viscosity of the first agent is 20,000 mPa·s or less. <Aspect 6> Aspect 6. The composition according to any one of Aspects 1 to 5, wherein the first agent includes at least one selected from fibers, pigments, dyes, and fillers. <Aspect 7> Aspect 7. The composition according to any one of aspects 1 to 6, wherein the second agent does not contain a pigment, a dye, or a filler. <Aspect 8> A method for using the composition for forming artificial skin according to any one of aspects 1 to 7, The first agent is applied to the body surface to form a first agent layer, and then a second agent is applied on the first agent layer and crosslinked to form artificial skin, or The second agent is applied to the body surface to form a second agent layer, and then the first agent is applied onto the second agent layer and crosslinked to form artificial skin. How to use. <Aspect 9> 9. The use according to embodiment 8, wherein the crosslinking time is 30 seconds or less. [Effects of the Invention]

[0010] According to the present disclosure, it is possible to provide a composition for forming artificial skin that can shorten the crosslinking time while maintaining excellent application performance and film-forming performance. [Brief explanation of the drawings]

[0011] [Figure 1] 1 is a photograph of a composition for forming artificial skin according to one embodiment of the present disclosure, which contains fibers, applied to the skin. [Figure 2] 1 is a graph showing the relationship between the viscosity of silicone oil and the crosslinking time. [Figure 3] 1 is a graph showing the weight loss rate, which is an index of the volatility of various oils. DETAILED DESCRIPTION OF THE INVENTION

[0012] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present disclosure is not limited to the following embodiments, and various modifications can be made within the scope of the present invention.

[0013] The composition for forming artificial skin of the present disclosure comprises a first agent and a second agent, wherein the first agent comprises (a) polymer A composed of one or more organopolysiloxanes having at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule, (b) polymer B composed of one or more organopolysiloxanes having at least two Si-H units in the molecule, and (c) a silicone having a viscosity of 1.5 mPa s or less at 25°C, and the second agent comprises a catalyst that promotes crosslinking of polymer A and polymer B.

[0014] Without being limited by the theory, it is believed that the principle of action by which the composition for forming artificial skin of the present disclosure can shorten the crosslinking time while maintaining excellent application performance and coating performance is as follows.

[0015] When using a one-component composition that does not involve a crosslinking reaction to form artificial skin, for example, adding a diluent with a high volatility rate can shorten the drying time after application to the skin, thereby shortening the time required to form the artificial skin. However, the composition of the present disclosure requires that after applying a first agent containing the above-mentioned polymer A and polymer B to the skin, a second agent containing a crosslinking-accelerating catalyst is further applied to crosslink polymer A and polymer B. Such two-component systems that involve drying and crosslinking reactions differ significantly in performance from simple one-component systems that do not involve crosslinking reactions in terms of compatibility, crosslinking reactivity, etc., and therefore the techniques used in such simple one-component systems cannot be directly used. For example, isododecane, a known oil that is easily volatile, was not able to contribute to shortening the crosslinking time of the composition of the present disclosure.

[0016] The present inventors have found that incorporating a relatively low-viscosity silicone oil into the first agent significantly contributes to shortening the crosslinking time of the composition of the present disclosure. Figure 2 is a graph showing this trend. In Figure 2, for example, a silicone oil with a viscosity of approximately 1.5 mPa·s and a crosslinking time of approximately 30 seconds is an oil that is less likely to volatilize than the silicone oil to the right, but this silicone oil is more effective in shortening the crosslinking time of the composition of the present disclosure. In other words, in the case of the composition of the present disclosure, it is believed that the viscosity of the oil, particularly the silicone oil, contributes more to shortening the crosslinking time than the volatility of the oil.

[0017] Furthermore, it is believed that silicones with such specific viscosities have excellent compatibility with polymer A and polymer B contained in the first agent, and can mix polymer A and polymer B well and in a balanced manner, thereby reducing or preventing the deterioration of application performance that accompanies an increase in viscosity and the deterioration of coating performance that accompanies uneven crosslinking formation.

[0018] The definitions of terms used in this disclosure are as follows:

[0019] In this disclosure, "viscosity" refers to a measure of the resistance of a fluid to being deformed by either shear stress or tensile stress. The viscosity of the first and second parts of a composition affects the thickness, spreadability, and uniformity and / or evenness of the layer formed on a substrate. Viscosity can be measured as dynamic viscosity (also known as absolute viscosity, typical units are Pa·s, poise, P, cP) or kinematic viscosity (typical units are cm 2Kinematic viscosity can be reported as either kinematic viscosity (kinematic viscosity in units of s / s, Stokes, St, or cSt), where kinematic viscosity is dynamic viscosity divided by the density of the measured fluid. Viscosity ranges for components disclosed herein are generally provided by each component supplier in units of kinematic viscosity (e.g., cSt) measured using a rheometer or a Cannon-Fenske tube viscometer, although fluid viscosity can also be measured using, for example, a rheometer (e.g., a linear shear rheometer or a dynamic shear rheometer) or a viscometer (viscometer, also called a capillary viscometer or rotational viscometer).

[0020] In the present disclosure, "crosslinking" also encompasses the concept generally referred to as "curing."

[0021] In this disclosure, "body surface" means the skin surface of the body.

[0022] 《Artificial skin formation composition》 The composition for forming artificial skin of the present disclosure (sometimes simply referred to as the "composition") can shorten the crosslinking time while maintaining excellent application performance and film-forming performance.

[0023] In some embodiments, the application performance of the composition can be evaluated by viscosity using a Brookfield viscometer (Vismetron, manufactured by Shibaura Systems Co., Ltd.). The viscosity of the first and second parts of the composition of the present disclosure immediately after preparation, measured at 25°C and 60 rpm (rotor No. 3 or No. 4), is, for example, 100 mPa·s or more, 500 mPa·s or more, 1,000 mPa·s or more, 2,000 mPa·s or more, 5,000 mPa·s or more, 7,500 mPa·s or more, 10,000 mPa·s or more, or 15,000 mPa·s or more. The viscosity can be 1,000,000 mPa·s or less, 750,000 mPa·s or less, 500,000 mPa·s or less, 250,000 mPa·s or less, 200,000 mPa·s or less, 175,000 mPa·s or less, 150,000 mPa·s or less, 125,000 mPa·s or less, 100,000 mPa·s or less, or 80,000 mPa·s or less. In particular, from the viewpoints of smooth application and suppression of dripping from the skin, the composition preferably has a viscosity of 20,000 mPa·s or less, 15,000 mPa·s or less, or 10,000 mPa·s or less, and preferably has a viscosity of 3,000 mPa·s or more, 5,000 mPa·s or more, or 7,000 mPa·s or more.

[0024] In some embodiments, the viscosity of the first and second parts of the composition of the present disclosure after two weeks, measured at 25°C and 60 rpm (rotor No. 3), is preferably 50,000 mPa·s or less, 30,000 mPa·s or less, or 15,000 mPa·s or less, and is preferably 5,000 mPa·s or more, 7,000 mPa·s or more, or 10,000 mPa·s or more, from the viewpoints of smooth application and suppression of dripping from the skin. The silicone blended in the first part has excellent compatibility with polymer A and polymer B, and therefore can reduce or prevent a significant increase in viscosity even after two weeks.

[0025] In some embodiments, the coating performance of the artificial skin can be evaluated, for example, by whether or not the artificial skin breaks when peeled off from the skin. For example, if the applied artificial skin breaks 15% or less, 10% or less, or 5% or less of the total, it can be said that the coating performance is excellent. There is no particular limit to the lower limit of breakage, but it can be specified as, for example, 0% or more or more than 0%. In addition, the coating performance can also be evaluated by tensile strength, breaking elongation, etc., as described below.

[0026] The crosslinking time of the compositions of the present disclosure can be evaluated using the following method.

[0027] After applying the first part to the aluminum substrate, the second part is applied to the entire surface by stirring it into the first part, and a timer is started. At a certain point in time in an atmosphere of 30°C, a 1.5 cm x 4 cm polypropylene sheet is placed on the surface to which the second part is applied, and then a 15 g weight is placed on the polypropylene sheet and waited for 2 seconds. The weight is then removed, and the polypropylene sheet is then removed from the application surface to observe whether or not the composition is adhering to the polypropylene sheet. The time when the composition is not observed after applying the polypropylene sheet is defined as the "crosslinking time."

[0028] In some embodiments, the composition of the present disclosure can achieve such a crosslinking time of 30 seconds or less, 25 seconds or less, or 20 seconds or less. There is no particular limitation on the lower limit of the crosslinking time, but it can be, for example, 5 seconds or more, 8 seconds or more, or 10 seconds or more.

[0029] <First agent> The first agent constituting the composition of the present disclosure contains (a) polymer A, (b) polymer B, and (c) a silicone having a viscosity at 25°C of 1.5 mPa·s or less.

[0030] The first agent may be, for example, in an anhydrous form, i.e., in a form in which polymers A and B are contained in silicone, which is an oil component, or in the form of an oil-in-water or water-in-oil emulsion. However, from the viewpoint of drying properties and crosslinking properties after application of the first agent to the body surface, it is advantageous for the first agent to be in an anhydrous form.

[0031] Anhydrous forms typically do not require preservatives against bacteria or mold and can therefore be stored for longer periods than emulsions of similar ingredients. In this disclosure, "anhydrous" not only connotes the absence of water in the composition, but also the presence of low amounts of water, i.e., 10% by weight or less, 5% by weight or less, 2% by weight or less, 1% by weight or less, or 0.1% by weight or less.

[0032] Since the first agent is applied to the body surface by application or the like, it preferably has a glass transition temperature below body temperature from the viewpoint of application performance. For example, the glass transition temperature can be 37°C or lower, 25°C or lower, 10°C or lower, or 0°C or lower. There is no particular restriction on the lower limit of the glass transition temperature, but it can be, for example, -30°C or higher, -20°C or higher, or -10°C or higher. Here, "glass transition temperature" refers to the temperature at which a transition from a solid state to a liquid state occurs, and can be measured, for example, using a differential scanning calorimeter (DSC) in accordance with ASTM D3418-03.

[0033] (a) Polymer A Polymer A is composed of one or more organopolysiloxanes having at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule, and preferably one or more organopolysiloxanes having an average of at least two alkenyl functional groups and a viscosity of 10,000 to 2,000,000 cSt at 25° C. Herein, in the present disclosure, the "carbon-carbon double bond" and the "carbon-carbon triple bond" may be simply referred to as the "double bond" and the "triple bond."

[0034] Such organopolysiloxanes may contain double or triple bonds in terminal units of the polymer, in non-terminal monomer units of the polymer, or a combination thereof, preferably in non-terminal monomer units of the polymer.

[0035] In some embodiments, the double bond-containing monomer units in the organopolysiloxane may be separated, on average, by 40 monomer units or more, 200 monomer units or more, 400 monomer units or more, 1,000 monomer units or more, or 2,000 monomer units or more.

[0036] In one embodiment, the amount of double- or triple-bond-containing monomer units in the organopolysiloxane having a double or triple bond can be, for example, 0.01% by weight or more, or 0.03% by weight or more, and can be 2% by weight or less, or 0.6% by weight or less.

[0037] In some embodiments, the vinyl equivalent weight of the organopolysiloxane having double or triple bonds can be, for example, 0.005 or more, or 0.01 or more, and 0.5 or less, or 0.25 or less per kilogram. The approximate molar amount of double or triple bonds in the organopolysiloxane can be calculated based on the average molecular weight of the organopolysiloxane. Here, the average molecular weight or molecular mass of each component disclosed herein is generally provided by the supplier of each component and is expressed in units of Daltons (Da) or the equivalent, g / mol.

[0038] In one embodiment, polymer A can have a viscosity of 10,000 to 2,000,000 cSt at 25° C. The lower limit of the viscosity is preferably 20,000 cSt or more, 40,000 cSt or more, 60,000 cSt or more, 80,000 cSt or more, or 100,000 cSt or more, and more preferably 125,000 cSt or more or 150,000 cSt or more. The upper limit of the viscosity is preferably 1,000,000 cSt or less, 500,000 cSt or less, 450,000 cSt or less, 400,000 cSt or less, 350,000 cSt or less, 300,000 cSt or less, or 250,000 cSt or less, more preferably 200,000 cSt or less or 180,000 cSt or less, and even more preferably 165,000 cSt or less.

[0039] In one embodiment, polymer A may have an average molecular weight of 60,000 Da to 500,000 Da. The lower limit of this average molecular weight is preferably 72,000 Da or more, 84,000 Da or more, 96,000 Da or more, or 100,000 Da or more, and more preferably 140,000 Da or more or 150,000 Da or more. The upper limit of the average molecular weight is preferably 200,000 Da or less, 190,000 Da or less, 180,000 Da or less, or 170,000 Da or less, more preferably 160,000 Da or less, and even more preferably 155,000 Da or less.

[0040] Polymer A is not limited to the following, for example, vinyl-terminated polydimethylsiloxane such as vinyl dimethicone, vinyl-terminated diphenylsiloxane-dimethylsiloxane copolymer, vinyl-terminated polyphenylmethylsiloxane, vinylphenylmethyl-terminated vinylphenylsiloxane-phenylmethylsiloxane copolymer, vinyl-terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymer, vinyl-terminated diethylsiloxane-dimethylsiloxane copolymer, vinylmethylsiloxane-dimethylsiloxane copolymer, trimethylsiloxy-terminated vinylmethylsiloxane-dimethylsiloxane copolymer, silanol-terminated vinylmethylsiloxane-dimethylsiloxane copolymer, vinylmethylsiloxane homopolymer, vinyl T-structure polymer (branched vinyl polymer), monovinyl-terminated polydimethylsiloxane, vinylmethylsiloxane terpolymer, and vinylmethoxysilane homopolymer can be used at least one selected from. Among them, vinyl-terminated polydimethylsiloxane is preferred, and vinyl dimethicone is more preferred.

[0041] The amount of polymer A in the first agent is not particularly limited and may be adjusted appropriately depending on the required coating performance, etc. For example, the amount of polymer A in the first agent as a whole may be 5% by mass or more, 10% by mass or more, 20% by mass or more, 30% by mass or more, 35% by mass or more, or 40% by mass or more, and may be 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, or 45% by mass or less.

[0042] ((b) Polymer B) Polymer B is composed of one or more organopolysiloxanes having at least two Si-H units in the molecule, and preferably one or more organopolysiloxanes having an average of at least two Si-H units and a viscosity of 2 to 100,000 cSt at 25°C.

[0043] In some embodiments, the organopolysiloxane having Si—H units may contain such Si—H units in terminal units of the polymer, in non-terminal monomer units of the polymer, or a combination thereof, preferably in non-terminal monomer units of the polymer.

[0044] In some embodiments, the Si—H containing monomer units in the organopolysiloxane may be separated, on average, by at least 1 monomer unit, at least 2 monomer units, at least 5 monomer units, at least 10 monomer units, at least 20 monomer units, at least 40 monomer units, at least 200 monomer units, at least 400 monomer units, at least 1,000 monomer units, or at least 2,000 monomer units.

[0045] In some embodiments, the amount of Si-H-containing monomer units in the organopolysiloxane having Si-H units can be 0.003% by weight or more, or 0.01% by weight or more, and can be 50% by weight or less, or 25% by weight or less.

[0046] In some embodiments, the Si-H content of the organopolysiloxane having Si-H units can be 0.1 mmol / g or more, 0.5 mmol / g or more, or 1 mmol / g or more, and 20 mmol / g or less, 10 mmol / g or less, or 5 mmol / g or less. The approximate molar amount of Si-H units in the organopolysiloxane can be calculated based on the average molecular weight of the organopolysiloxane.

[0047] In one embodiment, Polymer B may have a viscosity of 2 to 500,000 cSt at 25°C. The lower limit of this viscosity is preferably 3 cSt or more, 4 cSt or more, or 12 cSt or more, and more preferably 40 cSt or more. The upper limit of the viscosity is preferably 200,000 cSt or less, 100,000 cSt or less, 50,000 cSt or less, 20,000 cSt or less, 10,000 cSt or less, 5,000 cSt or less, 2,000 cSt or less, or 1,000 cSt or less, and more preferably 500 cSt or less. The viscosity of Polymer B is particularly preferably in the range of 45 to 100 cSt at 25°C.

[0048] In one embodiment, Polymer B can have an average molecular weight of 400 to 500,000 Da. The lower limit of this average molecular weight is preferably 500 Da or more, 800 Da or more, 1,200 Da or more, or 1,800 Da or more, and more preferably 2,000 Da or more. The upper limit of the average molecular weight is preferably 250,000 Da or less, 140,000 Da or less, 100,000 Da or less, 72,000 Da or less, 62,700 Da or less, 49,500 Da or less, 36,000 Da or less, or 28,000 Da or less, and more preferably 17,200 Da or less. The average molecular weight of Polymer B is particularly preferably in the range of 2,200 Da to 6,000 Da.

[0049] Polymer B may be at least one selected from, but not limited to, hydride-terminated polydimethylsiloxanes such as hydrogen dimethicone, hydride-terminated polyphenyl-(dimethylhydrosiloxy)siloxanes, hydride-terminated methylhydrosiloxane-phenylmethylsiloxane copolymers, trimethylsiloxy-terminated methylhydrosiloxane-dimethylsiloxane copolymers, polymethylhydrosiloxanes, trimethylsiloxy-terminated polyethylhydrosiloxanes, triethylsiloxanes, methylhydrosiloxane-phenyloctylmethylsiloxane copolymers, and methylhydrosiloxane-phenyloctylmethylsiloxane terpolymers. Among these, hydride-terminated polydimethylsiloxanes are preferred, and hydrogen dimethicone is more preferred.

[0050] The amount of polymer B in the first agent is not particularly limited and may be adjusted appropriately depending on the required coating performance, etc. For example, the amount of polymer B in the first agent may be 1% by mass or more, 3% by mass or more, or 5% by mass or more, and may be 75% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, 30% by mass or less, 20% by mass or less, or 10% by mass or less, based on the total amount of the first agent.

[0051] ((c) Silicone with a viscosity of 1.5 mPa·s or less at 25°C) Silicone with a viscosity of 1.5 mPa·s or less at 25°C (sometimes simply referred to as "silicone") is contained in the first agent as an oil. The viscosity of such silicone is intended to be the viscosity measured using a falling ball viscometer (Anton Paar, AMVn Automatic Micro Viscometer) at 25°C. The viscosity of the silicone can be 1.5 mPa·s or less, 1.4 mPa·s or less, 1.3 mPa·s or less, or 1.2 mPa·s or less. There is no particular lower limit for the viscosity of the silicone, but it can be, for example, 0.5 mPa·s or more, 0.7 mPa·s or more, or 1.0 mPa·s or more.

[0052] It is more preferable that the silicone is volatile from the viewpoint of shortening drying time, etc. Such volatility can be evaluated by the residual rate of silicone when 0.2 g of silicone is impregnated into filter paper and left for 60 minutes in an environment of room temperature 24°C and humidity 50%. The residual rate of silicone can be, for example, 20% or less, 15% or less, or 10% or less, or can be 0% or more or more than 0%.

[0053] As long as the viscosity is as described above, the type of silicone is not particularly limited, and examples thereof include polydimethylsiloxane (sometimes referred to as "dimethylsilicone") having 3 to 5 silicon atoms. Such silicones can be used alone or in combination of two or more.

[0054] The amount of silicone blended in the first agent is not particularly limited and may be adjusted appropriately depending on the application performance, crosslinking time, etc. For example, the amount of silicone blended can be 10% by mass or more, 15% by mass or more, 20% by mass or more, 25% by mass or more, 30% by mass or more, 35% by mass or more, or 40% by mass or more, and can be 70% by mass or less, 65% by mass or less, 60% by mass or less, 55% by mass or less, or 50% by mass or less, relative to the entire first agent.

[0055] <Second agent> The second agent constituting the composition of the present disclosure contains a catalyst that promotes crosslinking of the polymer A and polymer B described above.

[0056] The second agent may be, for example, in an anhydrous form, i.e., in a form in which the catalyst and any polymer C are contained in the oil component, or in the form of an oil-in-water or water-in-oil emulsion. However, from the viewpoint of the applicability and crosslinkability of the second agent to the surface to which the first agent is applied, it is advantageous for the second agent to be in the form of an oil-in-water or water-in-oil emulsion.

[0057] The second agent is applied to the surface to which the first agent is applied by painting or the like, and therefore, from the viewpoint of application performance, it preferably has a glass transition temperature equal to or lower than body temperature. For example, the glass transition temperature can be 37°C or lower, 25°C or lower, 10°C or lower, or 0°C or lower. There is no particular restriction on the lower limit of the glass transition temperature, but it can be, for example, -30°C or higher, -20°C or higher, or -10°C or higher.

[0058] (catalyst) Such catalysts are not particularly limited and may include, for example, any substance capable of causing, promoting, or initiating a physical and / or chemical crosslinking reaction, which may or may not undergo permanent physical and / or chemical changes during or at the end of the process.

[0059] Examples of the catalyst include, but are not limited to, metal catalysts that can initiate and / or accelerate crosslinking at or below body temperature, such as Group VIII metal catalysts, including platinum, rhodium, palladium, cobalt, nickel, ruthenium, osmium, and iridium catalysts, and Group IVA metal catalysts, including germanium and tin catalysts. Among these, platinum, rhodium, and tin catalysts are preferred. These catalysts can be used alone or in combination.

[0060] Platinum catalysts include, for example, platinum carbonylcyclovinylmethylsiloxane complexes, platinum divinyltetramethyldisiloxane complexes, platinum cyclovinylmethylsiloxane complexes, platinum octanaldehyde / octanol complexes, and other Pt(0) catalysts such as Karstedt's catalyst, platinum-alcohol complexes, platinum-alkoxide complexes, platinum-ether complexes, platinum-aldehyde complexes, platinum-ketone complexes, platinum-halogen complexes, platinum-sulfur complexes, platinum-nitrogen complexes, platinum-phosphorus complexes, platinum-carbon double bond complexes, platinum-carbon triple bond complexes, platinum-imido complexes, platinum-amide complexes, platinum-ester complexes, platinum-phosphate ester complexes, platinum-thiol ester complexes, platinum lone pair complexes, platinum-aromatic complexes, platinum π-electron complexes, and combinations thereof.

[0061] Rhodium catalysts include, for example, tris(dibutylsulfide)rhodium trichloride and rhodium trichloride hydrate.

[0062] Examples of tin catalysts include tin(II) octoate, tin(II) neodecanoate, dibutyltin diisooctylmaleate, di-n-butyltin bis(2,4-pentanedionate)tin, di-n-butylbutoxychlorotin, dibutyltin dilaurate, dimethyltin dineodecanoate, tin dimethylhydroxy(oleate), and tin(II) oleate.

[0063] Among these catalysts, platinum catalysts are more preferred, with platinum divinyltetramethyldisiloxane complexes being particularly preferred.

[0064] The amount of catalyst blended in the second agent is not particularly limited and may be adjusted appropriately depending on the required coating performance, etc. For example, the amount of catalyst blended can be 0.001% by mass or more, 0.005% by mass or more, or 0.01% by mass or more, and 1% by mass or less, 0.1% by mass or less, 0.05% by mass or less, or 0.03% by mass or less, relative to the entire second agent.

[0065] (Polymer C) The second agent may optionally contain polymer C.

[0066] In one embodiment, Polymer C may have a viscosity of 0.7 cSt to 10,000 cSt at 25° C. The lower limit of the viscosity is preferably 1 cSt or more, 6 cSt or more, 10 cSt or more, 20 cSt or more, 50 cSt or more, or 100 cSt or more, and more preferably 200 cSt or more. The upper limit of the viscosity is preferably 5,000 cSt or less, 4,000 cSt or less, 2,000 cSt or less, or 1,000 cSt or less, more preferably 500 cSt or less, and particularly preferably 250 cSt or less.

[0067] In one embodiment, Polymer C may have an average molecular weight of 180 Da to 65,000 Da. The lower limit of the average molecular weight is preferably 500 Da or more, 800 Da or more, 1,500 Da or more, 3,000 Da or more, or 6,000 Da or more, and more preferably 9,400 Da or more. The upper limit of the average molecular weight is preferably 50,000 Da or less, 45,000 Da or less, or 30,000 Da or less, more preferably 17,500 Da or less, and particularly preferably 10,000 Da or less.

[0068] Polymer C is preferably one or more organopolysiloxanes having on average at least one alkenyl functional group and a viscosity at 25°C of 0.7 to 10,000 cSt.

[0069] Specifically, examples of polymer C include vinyl-terminated polydimethylsiloxane, vinyl-terminated diphenylsiloxane-dimethylsiloxane copolymers such as vinyl dimethicone, vinyl-terminated polyphenylmethylsiloxane, vinylphenylmethyl-terminated vinylphenylsiloxane-phenylmethylsiloxane copolymers, vinyl-terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymers, vinyl-terminated diethylsiloxane-dimethylsiloxane copolymers, vinylmethylsiloxane-dimethylsiloxane copolymers, trimethylsiloxy-terminated vinylmethylsiloxane-dimethylsiloxane copolymers, silanol-terminated vinylmethylsiloxane-di At least one selected from methylsiloxane copolymers, vinyl-terminated vinyl rubbers, vinylmethylsiloxane homopolymers, vinyl T-structure polymers, vinyl Q-structure polymers, unsaturated organic polymers (e.g., unsaturated fatty alcohols, unsaturated fatty acids, unsaturated fatty esters, unsaturated fatty amides, unsaturated fatty urethanes, unsaturated fatty ureas, ceramides, crocetin, lecithin, and sphingosine), monovinyl-terminated polydimethylsiloxanes, vinylmethylsiloxane terpolymers, vinylmethoxysilane homopolymers, vinyl-terminated polyalkylsiloxane polymers, and vinyl-terminated polyalkoxysiloxane polymers can be used. Among these, vinyl-terminated polydimethylsiloxanes are preferred, and vinyl dimethicone is more preferred.

[0070] The amount of polymer C in the second agent is not particularly limited and may be adjusted appropriately depending on the required coating performance, etc. For example, the amount of polymer C in the second agent may be 0.01% by mass or more, 0.1% by mass or more, 0.3% by mass or more, or 0.5% by mass or more, and may be 20% by mass or less, 15% by mass or less, or 10% by mass or less, based on the total amount of the second agent.

[0071] <Functional group ratios in polymers A to C> In one embodiment, the molar ratio of Si-H functional groups from polymer B to alkenyl functional groups from polymer A is preferably from 60:1 to 1:5, more preferably from 45:1 to 15:1.

[0072] In one embodiment, the molar ratio of Si-H functional groups from polymer B to alkenyl functional groups from polymer C is preferably from 60:1 to 1:5, more preferably from 45:1 to 15:1.

[0073] In one embodiment, the molar ratio of alkenyl functional groups derived from polymer A to alkenyl functional groups derived from polymer C is preferably 100:1 to 1:100, more preferably 10:1 to 1:10.

[0074] <Optional ingredients> In the composition of the present disclosure, one or more optional ingredients may be blended with the first agent and / or the second agent.

[0075] The optional components are not particularly limited, and examples thereof include feel modifiers, tack modifiers, spreadability enhancers, diluents, adhesion modifiers, emulsifiers, emollients, surfactants, thickeners, solvents, film-forming agents, humectants, preservatives, fibers, pigments, dyes, fillers, skin permeation enhancers, optical modifiers, scattering agents, adsorbents, magnetic materials, gas transport modifiers, liquid transport modifiers, pH modifiers, sensitization modifiers, and aesthetic modifiers.

[0076] Emulsifiers can include, for example, alkoxydimethicones, alkyldimethicones, amodimethicones, sulfodimethicones, phosphodimethicones, borodimethicones, halodimethicones, fluorodimethicones, chlorodimethicones, bromodimethicones, charged dimethicones, and combinations thereof.

[0077] Examples of fillers include at least one selected from carbon, silver, mica, zinc sulfide, zinc oxide, titanium dioxide, aluminum oxide, clay, chalk, talc, calcite (e.g., CaCO), barium sulfate, zirconium dioxide, polymer beads, silica (e.g., fumed silica, silicic acid, or anhydrous silica), silica aluminate, and calcium silicate, which may be surface-treated. Such fillers can improve the physical properties (e.g., strength) of the coating (artificial skin) and can also function as viscosity adjusters. Among these, surface-treated silica, such as silica treated with a surface treatment agent such as hexamethyldisilazane, polydimethylsiloxane, hexadecylsilane, or methacrylsilane, is preferred. Fumed silica is also preferred, and fumed silica surface-treated with, for example, hexamethyldisilazane, can also be used.

[0078] In one embodiment, the filler is 50 to 500 m 2 The specific surface area of the filler can be 100 to 350 m / g. 2 / g, and 135 to 250m 2 / g Here, the specific surface area of the filler can be calculated using the BET method.

[0079] In one embodiment, the filler can have an equivalent circle diameter of 1 nm to 20 μm. The equivalent circle diameter of the filler is preferably 2 nm to 1 μm, and more preferably 5 nm to 50 nm. Here, the equivalent circle diameter of the filler can refer to the particle diameter when converted into a circular particle having the same area as the projected area of the filler particle observed under a transmission electron microscope, for example. Such equivalent circle diameter can be defined as the average value of 10 or more particles.

[0080] When a filler is blended into the first agent, the blending amount can be, for example, 1% by mass or more, 3% by mass or more, or 5% by mass or more, and 25% by mass or less, 15% by mass or less, or 10% by mass or less, relative to the entire first agent.

[0081] From the viewpoint of the reinforcement properties of the artificial skin, the mass ratio of the total amount of polymers A to C to the filler can be 100:1 to 1:1, preferably 50:1 to 2:1, more preferably 15:1 to 3:1, even more preferably 10:1 to 4:1, and particularly preferably 5:1 to 9:1.

[0082] Of the optional components, at least one selected from pigments, dyes, and fillers is preferably blended into the first agent. In particular, if pigments and dyes are blended into the second agent, the second agent may solidify during application to the surface to which the first agent is applied, which may lead to localized pigment or dye dispersion, resulting in color unevenness. From the perspective of suppressing color unevenness, it is advantageous to blend pigments and dyes into the first agent. Furthermore, pigments, dyes, and fillers may be blended into the second agent to the extent that color unevenness does not occur, but it is advantageous for these not to be included in the second agent.

[0083] In some embodiments, the composition of the present disclosure may further comprise one or more agents in addition to the first agent and / or the second agent, such as cosmetic agents, therapeutic agents, stimulus response agents, and drug delivery agents.

[0084] Suitable cosmetic agents may include, for example, moisturizers, UV absorbers, skin protectants, skin soothing agents, skin lightening agents, skin brightening agents, skin emollients, skin smoothing agents, skin bleaching agents, skin exfoliating agents, skin tightening agents, beauty agents, vitamins, antioxidants, cell signaling agents, cell regulating agents, cell interacting agents, skin tanning agents, anti-aging agents, anti-wrinkle agents, spot reducers, alpha-hydroxy acids, beta-hydroxy acids, and ceramides.

[0085] Suitable therapeutic agents can include, for example, pain relievers, analgesics, antipruritics, anti-acne agents (e.g., beta-hydroxy acids, salicylic acid, benzoyl peroxide), anti-inflammatory agents, antihistamines, corticosteroids, NSAIDs (nonsteroidal anti-inflammatory drugs), antiseptics, antibiotics, antibacterial agents, antifungals, antivirals, antiallergic agents, anti-irritants, insect repellents, phototherapy agents, blood coagulants, antineoplastic agents, immune system enhancers, immune system suppressants, coal tar, anthralin, fluocinonide, methotrexate, cyclosporine, pimecrolimus, tacrolimus, azathioprine, fluorouracil, ceramides, counterirritants, and skin cooling compounds.

[0086] Suitable agents can include, for example, antioxidants, vitamins, vitamin D3 analogs, retinoids, minerals, mineral oil, petrolatum, fatty acids, plant extracts, polypeptides, antibodies, proteins, sugars, humectants, and emollients.

[0087] <<Method of using the composition for forming artificial skin>> The artificial skin forming composition of the present disclosure can be used in, for example, cosmetic applications. or medical use Here, the method of using the composition for forming artificial skin of the present disclosure does not include methods for surgery, treatment, or diagnosis of humans.

[0088] Specifically, examples of methods for using the composition for forming artificial skin of the present disclosure include a method in which a first agent is applied to the body surface to form a first agent layer, and then a second agent is applied on the first agent layer and crosslinked to form artificial skin; or a method in which a second agent is applied to the body surface to form a second agent layer, and then the first agent is applied on the second agent layer and crosslinked to form artificial skin. From the perspective of obtaining uniform artificial skin with little unevenness, a preferred method of use is a method in which a first agent is applied to the body surface to form a first agent layer, and then a second agent is applied on the first agent layer and crosslinked to form artificial skin. Here, the materials described above can be used for the first agent and the second agent in the same manner.

[0089] This method may be performed once, but may also be performed multiple times on the formed artificial skin.

[0090] In some embodiments, the method of using the composition for forming artificial skin of the present disclosure can also be used as a cosmetic method. Note that the term "cosmetic method" refers to applying the composition for forming artificial skin of the present disclosure to a body surface to form artificial skin, thereby beautifying and adjusting the condition of the body surface, or a method of beautifying and adjusting the condition of the body surface, and is different from methods of surgery, treatment, or diagnosis for humans.

[0091] There are no particular limitations on the method of applying the first or second agent to the body surface or the first or second agent layer, and for example, methods such as spreading with fingers, spray application, and transfer can be used.

[0092] In the method of using the composition of the present disclosure, the first agent contains a silicone having a viscosity of 1.5 mPa·s or less at 25°C, and therefore, as described above, a crosslinking time of 30 seconds or less, 25 seconds or less, or 20 seconds or less can be achieved.

[0093] <Application area> The artificial skin forming composition of the present disclosure can be applied to any part of the skin surface of the body, i.e., any part of the body surface. For example, it can be appropriately applied to the skin surface of the face (lips, eyes, nose, cheeks, forehead, etc.), neck, ears, hands, arms, legs, feet, chest, abdomen, back, etc. Here, skin also includes nails where the keratin of the epidermis has changed and hardened.

[0094] 《Artificial skin》 <Thickness> The thickness of the artificial skin prepared using the artificial skin-forming composition of the present disclosure described above is not particularly limited and can be adjusted as appropriate, taking into account, for example, breathability, invisibility, compressibility, and occlusion of the skin. The thickness of the artificial skin can be, for example, 0.5 μm or more, 1 μm or more, 10 μm or more, 30 μm or more, or 40 μm or more. There is no particular upper limit to the thickness, but it can be, for example, 150 μm or less, 100 μm or less, 90 μm or less, 80 μm or less, 70 μm or less, 60 μm or less, or 50 μm or less. Here, the thickness can be defined as the average value calculated by measuring the thickness of any portion of the artificial skin five times using a high-precision Digimatic Micrometer (MDH-25MB, manufactured by Mitutoyo Corporation).

[0095] <Performance> Artificial skin prepared from the composition for forming artificial skin of the present disclosure can provide excellent results in various performance areas, for example, as shown below.

[0096] (adhesive strength) In some embodiments, the resulting artificial skin can exhibit good adhesive strength to the body surface. Such adhesive strength can be evaluated by measuring the adhesive strength of artificial skin applied to a polypropylene substrate. The adhesive strength of the artificial skin on a polypropylene substrate can be 2 N / m or more, 5 N / m or more, 8 N / m or more, 10 N / m or more, or 15 N / m or more. There is no particular upper limit to the adhesive strength, but from the viewpoint of ease of peeling from the skin, it can be set to 200 N / m or less, 100 N / m or less, 80 N / m or less, 50 N / m or less, or 30 N / m or less. Here, adhesive strength can be measured using an Instron device in accordance with the peel adhesion test of ASTM C794.

[0097] (tensile strength) In some embodiments, the resulting artificial skin can exhibit good tensile strength. The tensile strength of the artificial skin can be 0.05 MPa or more, 0.10 MPa or more, 0.20 MPa or more, or 0.50 MPa or more. There is no particular upper limit to the tensile strength, but it can be, for example, 5.0 MPa or less, 3.0 MPa or less, 2.0 MPa or less, or 1.0 MPa or less. Here, the tensile strength can be measured using an Instron device in accordance with the extension tensile test of ASTM D5083.

[0098] (Elongation at break) In some embodiments, the resulting artificial skin can exhibit good breaking elongation. The breaking elongation of the artificial skin can be 25% or more, 50% or more, 100% or more, 200% or more, or 400% or more. There is no particular upper limit to the breaking elongation, but it can be, for example, 1,500% or less, 1,200% or less, 1,000% or less, 800% or less, or 600% or less. Here, the breaking elongation can be measured using an Instron device in accordance with the ASTM D5083 extension tensile test.

[0099] (oxygen permeability) In some embodiments, the resulting artificial skin can exhibit good oxygen permeability. The oxygen permeability of the artificial skin is 5×10 for an artificial skin having a thickness of 300 μm. -9 cm 3 / (cm 2 ·s) or more, 5×10 -7 cm 3 / (cm 2 s) or more, or 5 × 10 -5 cm 3 / (cm 2 There is no particular upper limit to the oxygen permeability. 3 / (cm 2 ·s) or less, 0.5cm 3 / (cm 2 ·s) or less, 5×10 -2 cm 3 / (cm 2·s) or less, 5×10 -3 cm 3 / (cm 2 s) or less, or 5 × 10 -4 cm 3 / (cm 2 The oxygen permeability can be measured using a remote control device in accordance with ASTM F2622, oxygen gas permeability test for plastic films and sheets.

[0100] (Water vapor permeability) In some embodiments, the resulting artificial skin can exhibit good water vapor permeability. The water vapor permeability of the artificial skin is 1×10 for a 300 μm thick artificial skin. -9 cm 3 / (cm 2 ·s) or more, 1×10 -8 cm 3 / (cm 2 s) or more, or 1×10 -7 cm 3 / (cm 2 There is no particular upper limit to the water vapor transmission rate, but for example, 1.5×10 -1 cm 3 / (cm 2 ·s) or less, 1.5×10 -2 cm 3 / (cm 2 ·s) or less, 1×10 -4 cm 3 / (cm 2 ·s) or less, 1×10 -5 cm 3 / (cm 2 s) or less, or 1×10 -6 cm 3 / (cm 2 The water vapor transmission rate can be measured using a remote control device in accordance with ASTM F1249, Water Vapor Transmission Rate Test for Plastic Films and Sheets.

[0101] <<Kit including a composition for forming artificial skin>> The composition for forming artificial skin of the present disclosure can be provided as a kit containing the first and second agents that constitute the composition. In addition to the first and second agents, the kit may also contain optional components, for example, to facilitate application of the first agent or the like to the body surface or for further application of makeup.

[0102] Examples of such optional components include an instruction manual, a brush, a cotton swab, a cutter, scissors, gloss, lipstick, nail polish, foundation, a cleanser for removing artificial skin from the body surface, a mirror, etc. Here, the "instruction manual" may include not only a general instruction manual attached in the form of a document to the kit, but also instructions printed on a packaging container that contains the kit or a packaging container such as a tube for injecting the first agent, etc.

[0103] In some embodiments, the kit may be configured to prevent contact between the first and second agents, for example, by packaging the agents in separate containers or compartments and applying them one at a time or mixing them together before or at the time of use. [Example]

[0104] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these. Unless otherwise specified, the blending amounts are expressed in mass %.

[0105] Examples 1 to 4 and Comparative Examples 1 to 7 The first agent was prepared by uniformly mixing polymer A, polymer B, oil, and filler according to the formulations shown in Table 1. The viscosity of this first agent after two weeks and the viscosity of each oil used in the first agent were evaluated using the method described below, and the results are shown in Table 1. In addition, the residual rate, which serves as an indicator of the volatility of each oil used in the first agent, was evaluated using the method described below, and the results are also shown in Table 1.

[0106] According to the composition in Table 2, the platinum catalyst dispersed in silicone oil and the components other than potassium hydroxide dissolved in a portion of water were uniformly mixed to prepare an aqueous phase. The platinum catalyst dispersed in silicone oil was then mixed into the aqueous phase, and an aqueous potassium hydroxide solution was further added to neutralize the mixture, preparing a second part. The crosslinking time of the composition was evaluated using the first and second parts prepared as described below. The results are shown in Table 1.

[0107] Furthermore, Figure 2 shows a graph showing the relationship between the viscosity of the silicone oils in Table 1, namely, a mixture of dimethyl silicone (dimethicone) and trisiloxane, diphenylsiloxyphenyl trimethicone, five types of dimethicone with different viscosities, and caprylyl methicone, and the crosslinking time of the compositions in the examples and comparative examples that used these oils.

[0108] For reference, a graph showing the weight loss rates, which serve as an indicator of volatility, for two types of dimethicone with different viscosities, a mixture of dimethyl silicone (dimethicone) and trisiloxane, isododecane, isoparaffin, and caprylyl methicone is shown in Figure 3. The weight loss rates were determined in the same manner as the method for evaluating the residual oil content, which will be described later.

[0109] Evaluation Method (Viscosity evaluation) The viscosity of the first agent was evaluated using a B-type viscometer (Shibaura Systems Co., Ltd., Vismetron) at rotor number 3 or 4 and 60 rpm, and the viscosity of the oil component was evaluated using a falling ball viscometer (Anton Paar, AMVn automatic micro viscometer) at 25°C.

[0110] (Evaluation of crosslinking time) After applying 71 μl of the first part to an aluminum substrate, 100 μl of the second part was applied to the entire surface while stirring the first part, and a timer was started. At a certain point in time in a 30°C atmosphere, a 1.5 cm x 4 cm polypropylene sheet was placed on the surface coated with the second part. A 15 g weight was then placed on the polypropylene sheet and the polypropylene sheet was left for 2 seconds. The weight was then removed, and the polypropylene sheet was removed from the coated surface. The time when the composition was no longer observed after applying the polypropylene sheet was recorded as the "crosslinking time."

[0111] (Evaluation of oil residual rate (volatility)) 0.2 g of each oil shown in Table 1 was dropped onto a filter paper placed on an electronic balance and left to stand for 60 minutes in an environment of room temperature 24°C and humidity 50%, after which the weight of the oil was measured and the weight loss rate (%) of the oil was calculated using the following formula 1. This was then introduced into formula 2 to calculate the residual rate (%) of the oil, which serves as an indicator of volatility: Oil weight loss rate (%) = (0.2 (g) - oil amount after 60 minutes (g)) x 100 / 0.2 (g) ...Equation 1 Oil remaining rate (%) = 100 - oil weight loss rate ... Equation 2

[0112] [Table 1]

[0113] [Table 2]

[0114] <result> As can be seen from the results in Figure 2, when the oil contained in the first agent is a silicone-based oil, it was confirmed that the crosslinking time is shortened as the viscosity of the oil decreases.

[0115] Furthermore, for example, when Example 2 and Comparative Example 7 in Table 1 are compared, the isododecane of Comparative Example 7 had a crosslinking time that was more than three times longer than the dimethicone of Example 2, even though it had the same viscosity and volatility (residual rate) as the dimethicone of Example 2. As can be seen from these results, in order to shorten the crosslinking time in a composition containing a first agent containing specific polymers A and B and a second agent containing a catalyst that promotes crosslinking, it was confirmed that it is not enough for the oil to be blended in the first agent to be an oil with a high volatility rate, but rather it is important to employ a silicone with a specific viscosity.

[0116] Examples 5 to 8 The dispersion of the fibers in the fiber-blended system and the ability to form artificial skin were evaluated.

[0117] [Table 3]

[0118] <result> A first agent containing fibers was prepared according to the composition in Table 3, and then this first agent was applied to the skin, and the above-mentioned second agent was applied on top of it by stirring it into the first agent. It was confirmed that good artificial skin was formed in all of Examples 5 to 8. Here, the lower part of the back of the hand in Figure 1 is the artificial skin prepared using the first agent of Example 7, and the upper part of the back of the hand in Figure 1 is the artificial skin prepared using the first agent of Example 8. In all cases, as shown in Figure 1, the blended fibers showed good dispersibility in the artificial skin.

[0119] <Prescription examples for the first and second drugs> Below, examples of formulations for the first and second agents of the composition for forming artificial skin of the present disclosure are listed in Tables 4 to 8, but the first and second agents of the composition for forming artificial skin of the present invention are not limited to these examples.

[0120] [Table 4]

[0121]

Table 5

[0122]

Table 6

[0123]

Table 7

[0124]

Table 8

Claims

1. A composition for forming artificial skin, comprising a first agent and a second agent, the first agent comprises: (a) a polymer A composed of one or more organopolysiloxanes having at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule; (b) a polymer B composed of one or more organopolysiloxanes having at least two Si—H units in the molecule; and (c) a silicone having a viscosity at 25° C. of 1.5 mPa s or less; the second agent contains a catalyst that promotes crosslinking of the polymer A and the polymer B; composition.

2. 2. The composition according to claim 1, wherein the silicone is a polydimethylsiloxane having 3 to 5 silicon atoms.

3. 3. The composition of claim 1, wherein the polymer A is at least one selected from the group consisting of vinyl-terminated polydimethylsiloxane, vinyl-terminated diphenylsiloxane-dimethylsiloxane copolymer, vinyl-terminated polyphenylmethylsiloxane, vinylphenylmethyl-terminated vinylphenylsiloxane-phenylmethylsiloxane copolymer, vinyl-terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymer, vinyl-terminated diethylsiloxane-dimethylsiloxane copolymer, vinylmethylsiloxane-dimethylsiloxane copolymer, trimethylsiloxy-terminated vinylmethylsiloxane-dimethylsiloxane copolymer, silanol-terminated vinylmethylsiloxane-dimethylsiloxane copolymer, vinylmethylsiloxane homopolymer, vinyl T-structure polymer, monovinyl-terminated polydimethylsiloxane, vinylmethylsiloxane terpolymer, and vinylmethoxysilane homopolymer.

4. The composition according to any one of claims 1 to 3, wherein the polymer B is at least one selected from the group consisting of hydride-terminated polydimethylsiloxane, hydride-terminated polyphenyl-(dimethylhydrosiloxy)siloxane, hydride-terminated methylhydrosiloxane-phenylmethylsiloxane copolymer, trimethylsiloxy-terminated methylhydrosiloxane-dimethylsiloxane copolymer, polymethylhydrosiloxane, trimethylsiloxy-terminated polyethylhydrosiloxane, triethylsiloxane, methylhydrosiloxane-phenyloctylmethylsiloxane copolymer, and methylhydrosiloxane-phenyloctylmethylsiloxane terpolymer.

5. The composition according to any one of claims 1 to 4, wherein the viscosity of the first agent is 20,000 mPa·s or less.

6. The composition according to any one of claims 1 to 5, wherein the first agent contains at least one selected from the group consisting of fibers, pigments, dyes, and fillers.

7. The composition according to any one of claims 1 to 6, wherein the second agent does not contain pigments, dyes, or fillers.

8. A method for using the composition for forming artificial skin according to any one of claims 1 to 7, The first agent is applied to the body surface to form a first agent layer, and then a second agent is applied on the first agent layer and crosslinked to form artificial skin, or The second agent is applied to the body surface to form a second agent layer, and then the first agent is applied onto the second agent layer and crosslinked to form artificial skin. Methods of use (excluding methods of surgery, treatment or diagnosis of humans).

9. 9. The method of claim 8, wherein the crosslinking time is 30 seconds or less.

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