Cosmetic product suggestion system and cosmetic product suggestion method

Abstract

To provide a system and method capable of proposing cosmetics verified to be suitable for a customer. [Solution] A cosmetics suggestion system, wherein the customer information receiving means is a means for receiving customer information, the screening result receiving means is a means for receiving screening results of candidate ingredients for cosmetics to be provided to the customer, the active ingredient determining means is a means for determining the active ingredients of the cosmetics that are suitable for the customer based at least on the screening results, and the output means is a means for outputting information on the cosmetics that are suitable for the customer, including information on the determined active ingredients, linked to the customer information received by the customer information receiving means, and the screening applies the candidate ingredients to three-dimensional skin tissue created from cells derived from the customer, and observes the biological response of the three-dimensional skin tissue as an evaluation index to select ingredients that can improve the customer's skin condition.

Description

[Technical Field]

[0001] The present invention relates to a system for suggesting cosmetics suited to a customer and a method for suggesting cosmetics suited to a customer. [Background technology]

[0002] One of the factors that consumers consider when selecting cosmetics is whether or not they will solve their skin concerns (blemishes, wrinkles, dullness, etc.) Even if the purpose is the same, cosmetics come in a wide variety of formulations and forms, and consumers select cosmetics by considering whether the ingredients contained in the cosmetics can solve their skin concerns and whether they will have any adverse effects on their skin. However, in many cases, it is impossible to know whether a cosmetic product will actually solve your skin problems until you actually try using it for a long time. Also, depending on the consumer's skin type, constitution, and lifestyle, the cosmetic product they purchased may not only be ineffective, but may actually exacerbate their skin problems or even cause other skin problems. Therefore, even if people purchase cosmetics in the hope of solving their skin problems, they often end up not getting satisfactory results.

[0003] To overcome this situation, systems have been developed that suggest cosmetics based on customers' skin information. For example, Patent Document 1 describes a cosmetic creation system that includes a skin type determination device and a cosmetic blending device. The skin type determination device includes a first evaluation unit that evaluates the skin type of a subject as a first skin type before a standard cosmetic for skin type determination is applied to a predetermined area of ​​the subject, a second evaluation unit that evaluates the skin type of the subject as a second skin type after the standard cosmetic is applied to the predetermined area of ​​the subject, an overall evaluation unit that evaluates an overall skin type based on both the first skin type and the second skin type, and also includes the subject's receptivity to cosmetics, and a transmission unit that transmits skin type information indicating the overall skin type along with the user ID of the subject. The cosmetic blending device includes a receiving unit that receives the user ID and skin type information of the subject, a cosmetic creation unit that identifies blend amounts of multiple cosmetic ingredients corresponding to the subject's overall skin type and creates cosmetics based on the identified blend amounts, and a cosmetic management unit that registers the user ID of the subject and the ID of the cosmetic that the subject instructed to create, in association with each other. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] International Publication No. 2021 / 079468 Summary of the Invention [Problem to be solved by the invention]

[0005] The system described in Patent Document 1 creates cosmetics based on the blending amounts of cosmetic ingredients specified for a user based on their overall skin type. However, it does not verify whether the created cosmetics are suitable for the user. In other words, whether the created cosmetics truly solve the user's skin concerns cannot be known until the user tries them out.

[0006] In view of the above circumstances, an object of the present invention is to provide a system and method that can propose cosmetics that have been verified to be suitable for a customer. [Means for solving the problem]

[0007] The present invention, which solves the above-mentioned problems, is a cosmetic product suggestion system including a customer information receiving means, a screening result receiving means, an active ingredient determining means, and an output means, the customer information receiving means is a means for receiving customer information, the screening result receiving means is means for receiving the screening results of candidate ingredients for the cosmetic to be provided to the customer; the active ingredient determination means is means for determining an active ingredient of the cosmetic suitable for the customer based at least on the screening results, the output means outputs information about the cosmetics suitable for the customer, including information about the determined active ingredients, in association with the customer information received by the customer information receiving means; The screening involves applying the candidate ingredients to three-dimensional skin tissue created from cells derived from the customer, observing the biological response of the three-dimensional skin tissue as an evaluation index, and selecting ingredients that may improve the customer's skin condition.

[0008] The three-dimensional skin tissue created from cells derived from a customer has the characteristics of the customer's skin, such as the customer's skin type, constitution, reaction to chemicals, etc. Therefore, it is expected that the reaction of the three-dimensional skin tissue to chemicals will be the same as the reaction of the customer's actual skin, or at least a reaction that can be used to estimate the reaction of the customer's actual skin. Therefore, according to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0009] In a preferred embodiment of the present invention, the three-dimensional skin tissue is a skin organoid produced from cells derived from the customer. Unlike simple cell masses, skin organoids are tissues that function as skin. In other words, skin organoids created from cells derived from a customer have the characteristics of the customer's actual skin and also function as skin. Therefore, the response of skin organoids to chemicals is expected to be the same as the response of the customer's actual skin, or at least a response that can be estimated from the response of the customer's actual skin. Therefore, according to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0010] In a preferred embodiment of the present invention, the customer information includes skin condition information that is information representing the skin condition of the customer, The active ingredient determining means determines the active ingredients of the cosmetic that are suitable for the customer based on the screening results and the skin condition. The condition of a customer's skin, such as color-related conditions such as blemishes and dullness, skin morphology such as wrinkles and texture, skin responsiveness to external stimuli (e.g., dry skin, sensitive skin, etc.), and the state of the skin's barrier function, often influences the reaction to chemicals. Furthermore, these conditions are often directly linked to the customer's skin concerns (skin worries). The customer information includes information on skin condition, and by determining the active ingredients of the cosmetics based on the screening results and the skin condition, it is possible to propose cosmetics that are suitable for the customer's skin condition and have been verified as being suitable for the customer.

[0011] In a preferred embodiment of the present invention, the active ingredient is an ingredient that improves the skin condition. As described above, the customer's skin condition, such as color-related conditions such as spots and dullness, and skin morphology-related conditions such as wrinkles and texture, are often directly linked to the customer's skin concerns (skin worries). Therefore, by using ingredients that improve skin condition as active ingredients, it is possible to verify whether the cosmetics are suitable for the customer, and to propose cosmetics that are more likely to improve the customer's skin problems than cosmetics proposed by conventional systems.

[0012] In a preferred embodiment of the present invention, the customer information further includes one or more pieces of information selected from the customer's medical history, lifestyle habits, and beauty habits, The active ingredient determining means determines the active ingredient based on at least the skin condition, the screening results, and one or more pieces of information selected from the customer's medical history, lifestyle habits, and beauty habits.

[0013] Even if an active ingredient is determined to be suitable for a customer as a result of screening using three-dimensional skin tissue, it is possible that the inclusion of that active ingredient in cosmetics may be contraindicated or it may be determined that it is preferable to avoid it in light of the customer's medical history.Furthermore, in light of the customer's lifestyle and beauty habits, it is possible that an ingredient determined to be second or subsequent to the active ingredient determined to be most suitable for the customer as a result of screening may actually be more effective. In such cases, the active ingredients can be determined by taking into account the customer's skin condition and screening results, as well as one or more pieces of information selected from medical history, lifestyle habits, and beauty habits, making it possible to provide the customer with personalized cosmetics. Therefore, according to the present invention, whether or not a cosmetic product is suitable for a customer can be verified, and personalized cosmetics can be proposed.

[0014] In a preferred embodiment of the present invention, the system further comprises a beauty regimen determination unit that determines a beauty regimen suited to the customer based on the customer information, The output means outputs information on cosmetics suitable for the customer and the determined beauty treatment method suitable for the customer, linked to the customer information. In addition to using cosmetics, the effects of cosmetics may be enhanced by engaging in beauty-related activities such as beauty treatments, massage, exercise, and diet. Therefore, according to the present invention, it is possible to simultaneously propose a cosmetic product that has been verified to be suitable for a customer and a beauty regimen that is suitable for the customer. By combining these cosmetic products and beauty regimens, the customer is more likely to achieve the desired results.

[0015] In a preferred embodiment of the present invention, the system includes means for updating the criteria for determining the active ingredient by the active ingredient determining means based on the screening results and evaluations of the cosmetic agent collected from the customers. As mentioned above, even if the ingredients are the same, whether or not they are effective and to what extent they are effective can vary depending on the customer's constitution, medical history, habits, etc. Therefore, by updating the criteria for determining active ingredients by the active ingredient determination means to suit the customer based on the screening results and evaluations from customers who have actually used the proposed cosmetics, it is possible to propose more personalized cosmetics. Furthermore, by updating the criteria for determining active ingredients by the active ingredient determination means for the entire system based on evaluations from multiple customers, it is possible to propose cosmetics that are more suited to the customer.

[0016] In a preferred embodiment of the present invention, in the above system, the active ingredient determining means determines the active ingredient and the amount of the active ingredient to be blended in the cosmetic that is suitable for the customer. As mentioned above, even if the ingredients are the same, whether or not they are effective and to what extent they are effective can vary depending on the customer's constitution, medical history, habits, etc. Therefore, if the active ingredient determining means determines not only the active ingredient but also the amount of the active ingredient to be blended in the cosmetic, it is possible to propose a more personalized cosmetic.

[0017] In a preferred embodiment of the present invention, the screening comprises applying the candidate component to the three-dimensional skin tissue prepared from cells derived from the customer in the presence of a biological sample derived from the customer. Three-dimensional skin tissue created from cells derived from a customer has the characteristics of the customer's skin, such as their skin type, constitution, and reaction to chemicals, but it also contains tissues that the three-dimensional skin tissue does not have, such as immune cells and blood. Therefore, by applying candidate ingredients to three-dimensional skin tissue created from cells derived from a customer in the presence of immune cells, blood, and other tissues not present in three-dimensional skin tissue, screening can be performed in an environment closer to that inside the customer's body, allowing for the proposal of more personalized cosmetics.

[0018] In a preferred embodiment of the present invention, the screening is carried out using a three-dimensional skin tissue prepared from cells derived from the customer and reflecting the customer's current skin condition. It is conceivable that as a result of continued use of the proposed cosmetic product, the customer's skin condition will improve and become different from the initial skin condition. Therefore, according to the present invention, by using three-dimensional skin tissue that reflects the (current) skin condition after changes due to the use of cosmetics, it is possible to propose more personalized cosmetics that respond to changes in the customer's skin condition.

[0019] In a preferred embodiment of the present invention, the system further comprises a storage means; the storage means stores corresponding active ingredient data in which the evaluation index and the active ingredient corresponding to the evaluation index are linked; The active ingredient determination means refers to the corresponding active ingredient data and determines, among the evaluation indexes observed in the screening, the active ingredient corresponding to the evaluation index that indicates effectiveness on the customer's skin as the active ingredient of the cosmetic that is suitable for the customer. According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0020] In a preferred embodiment of the present invention, the storage means further stores data linking the customer information with an identifier capable of uniquely identifying the customer. According to the present invention, customer information can be easily managed.

[0021] In a further preferred embodiment of the present invention, the storage means further stores data linking the screening results of the customer with the customer's identifier. According to the present invention, it is possible to easily compare the results of screening using different components as candidate components. Furthermore, if multiple screening results are available, it is possible to track changes in the customer's skin condition and determine the active ingredient based on those changes.

[0022] In a preferred embodiment of the present invention, an identification code corresponding to the identifier is attached to a container used to collect the cells derived from the customer and / or a culture container used in the process of producing the three-dimensional skin tissue. In order to propose cosmetics that are suitable for each customer, it is necessary to manage the cells collected from one customer and the three-dimensional skin tissue created from those cells so that they are not confused with those of another customer. According to the present invention, it becomes easy to manage cells and three-dimensional skin tissue for each customer.

[0023] In a preferred embodiment of the present invention, the storage means stores the customer's identifier in association with storage intention information, which is information regarding consent to one or more processes selected from storage, storage period, and disposal of cells derived from the customer and / or three-dimensional skin tissue created from cells derived from the customer. From the standpoint of privacy, when storing customer-derived cells or three-dimensional skin tissue created from customer-derived cells, it is preferable to obtain consent from the customer in advance, including regarding the storage period and disposal time. Therefore, according to the present invention, the reliability and transparency of the system can be improved.

[0024] In a preferred embodiment of the present invention, the storage means stores the customer's identifier, the culture conditions for the three-dimensional skin tissue produced from cells derived from the customer, the conditions for carrying out one or more previous screenings, and the results of one or more previous screenings, all linked together. It is expected that the customer's skin condition will improve as a result of continued use of the proposed cosmetics. Therefore, it is preferable to conduct regular screening and change the cosmetic formulation in accordance with changes in skin condition in order to continuously improve the customer's skin condition. Furthermore, from the perspective of customer satisfaction, it is preferable to design the second and subsequent screenings based on the cell culture conditions and screening conditions used in the previous screenings, thereby shortening the time required to obtain screening results and shortening the time from receiving a customer's application to proposing a cosmetic product to the customer. Therefore, according to the present invention, it is possible to continuously recommend cosmetics based on the skin condition. Furthermore, according to the present invention, it is possible to shorten the time until the second or subsequent screening results are obtained, thereby improving the speed at which cosmetics can be recommended to customers.

[0025] The present invention, which solves the above-mentioned problems, comprises: a screening step of screening for an active ingredient that improves the skin condition of a customer using three-dimensional skin tissue prepared from cells derived from the customer; and a cosmetic suggestion step of suggesting a cosmetic containing the active ingredient. According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0026] In a preferred embodiment of the present invention, the method further comprises a sample collection step of collecting cells from the customer; and a three-dimensional skin tissue preparation step of preparing the three-dimensional skin tissue from the collected cells. According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0027] In a preferred embodiment of the present invention, in the above method, the three-dimensional skin tissue is a skin organoid. As described above, skin organoids have the characteristics of a customer's actual skin and also function as skin. Therefore, it is expected that the response of skin organoids to chemicals will be the same as the response of the customer's actual skin, or at least a response that can be estimated from the response of the customer's actual skin. Therefore, according to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0028] In a preferred embodiment of the present invention, the cosmetic suggestion step of the method is performed using a cosmetic suggestion system as defined in claim 1. According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer. [Effects of the Invention]

[0029] According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer. [Brief explanation of the drawings]

[0030] [Figure 1] 1 is a functional block diagram of a cosmetic suggestion system according to a first embodiment of the present invention. [Figure 2] 3 is a flowchart showing the flow of processing by the cosmetic suggestion system of the first embodiment. [Figure 3] FIG. 3 is a functional block diagram of a cosmetic suggestion system according to a second embodiment of the present invention. [Figure 4] 10 is a flowchart showing the flow of processing by the cosmetic suggestion system of the second embodiment. [Figure 5] FIG. 10 is a functional block diagram of a cosmetic suggestion system according to a third embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0031] The system according to the present invention may be described using the following hypothetical example, but the technical scope of the present invention is not limited to the following hypothetical example. <Hypothetical example> Candidate ingredients for cosmetics: 4 types: Component A, Component B, Component C, and Component D Evaluation items for candidate ingredients: X (wrinkle-related), Y (dullness-related), Z (dry skin-related) Biological response (evaluation index): Expression level of gene G. Gene G is a gene involved in wrinkle formation. Increased expression of gene G promotes wrinkle formation. Screening Results: When three-dimensional skin tissue prepared from cells derived from a certain customer was cultured for an appropriate period in the presence of component A, the expression level of gene G decreased compared to the control (expression of gene G was suppressed). When three-dimensional skin tissue prepared from cells derived from the same customer was cultured for an appropriate period in the presence of components B, C, or D, the expression level of gene G either did not change or increased compared to the control (expression of gene G was not suppressed).

[0032] 1. Cosmetic product suggestion system The following describes the configuration, operation, etc. of a cosmetic product recommendation system in a specific embodiment, but similarly configured methods, devices, computer programs, etc. can also achieve similar effects. The program may also be stored on a recording medium. Using this recording medium, the program can be installed on a computer, for example. Here, the recording medium storing the program may be a non-transitory recording medium, such as a CD-ROM. In the present invention, the cosmetic material includes any of cosmetics, quasi-drugs, and pharmaceuticals (external and internal preparations).

[0033] First Embodiment A first embodiment of the present invention will be described with reference to FIGS. 1 is a functional block diagram of a cosmetics suggestion system according to a second embodiment. The cosmetics suggestion system according to this embodiment is configured so that a server device 1 and a user terminal 2 can communicate with each other via a network NW. Here, in the present invention, a "user" refers to a person who uses the cosmetic recommendation system of the present invention. In other words, users of the cosmetic recommendation system of the present invention include both customers who are the target of cosmetic recommendations (i.e., who actually use the recommended cosmetics) and those who propose the cosmetics, such as employees or researchers of cosmetics companies. The server device 1 may also be realized by having a plurality of computers work together.

[0034] The server device 1 can be a general computer device such as a server device equipped with an arithmetic device such as a CPU (Central Processing Unit) or a GPU (Graphics Processing Unit), a main memory device such as a RAM (Random Access Memory), an auxiliary memory device such as an HDD (Hard Disk Drive), an SSD (Solid State Drive), or a flash memory, and various input / output devices including a means for connecting to a network NW.

[0035] As shown in FIG. 1, the server device 1 includes a customer information receiving means 11, a screening result receiving means 12, an active ingredient determining means 13, and an output means .

[0036] The customer information receiving means 11 is a means for receiving input of customer information. The screening result receiving means 12 is a means for receiving input of the screening results of candidate ingredients for cosmetics to be provided to customers. The active ingredient determining means 13 is a means for determining the active ingredients of the cosmetic that are suitable for the customer based at least on the screening results. The output means 14 is a means for linking information about cosmetics suitable for the customer, including information about the determined active ingredients, with the customer information received by the customer information receiving means 11 and outputting the information.

[0037] Here, the screening involves applying candidate components to three-dimensional skin tissue created from cells derived from the customer, observing the biological response of the three-dimensional skin tissue as an evaluation index, and selecting components that can improve skin condition. By determining the active ingredients of cosmetics that are suitable for a customer based on the screening results using three-dimensional skin tissue created from cells derived from the customer, it is possible to propose cosmetics that have been verified to be suitable for the customer.

[0038] In addition, screening may be performed manually after creating three-dimensional skin tissue, applying candidate components to the three-dimensional skin tissue, observing biological reactions in the three-dimensional skin tissue, and determining whether the candidate components are effective against the evaluation index. Alternatively, the effective ingredient determination means 13 may observe the biological reaction in the three-dimensional skin tissue and determine whether the candidate ingredient shows effectiveness for the evaluation index. Preferably, the effective ingredient determination means 13 observes the biological reaction in the three-dimensional skin tissue and determines whether the candidate ingredient shows effectiveness for the evaluation index.

[0039] In the present invention, "suitable for the customer" means that there is a high possibility of improving the customer's skin concerns (skin concerns). "Suitable for the customer" may also include maintaining the customer's skin condition (i.e., preventing skin concerns). "Suitable for the customer" may also mean that there is a high possibility of improving the customer's skin concerns and that it is suited to the customer's constitution, etc.

[0040] In the screening of the present invention, "applying a candidate component to a three-dimensional skin tissue" means maintaining a state in which the candidate component can act on the three-dimensional skin tissue for a certain period of time. Examples include, but are not limited to, culturing a three-dimensional skin tissue prepared from customer-derived cells in the presence of a candidate component of a cosmetic (i.e., in a culture medium containing the candidate component), or dropping the candidate component onto a three-dimensional skin tissue prepared from customer-derived cells. Preferably, applying the candidate component to the three-dimensional skin tissue involves culturing the three-dimensional skin tissue prepared from cells derived from the customer in the presence of the candidate component of the cosmetic. In this case, the culturing period, culturing conditions (temperature, humidity, etc.), concentration of the candidate component, etc. are not particularly limited, as long as the biological response of the three-dimensional skin tissue can be observed.

[0041] The three-dimensional skin tissue created from cells derived from a customer has characteristics similar to those of the customer's skin, such as the customer's skin type and constitution, skin tissue structure, reaction to chemicals, etc. Therefore, the reaction of the three-dimensional skin tissue to chemicals is expected to be the same as the reaction of the customer's actual skin, or at least a reaction that can be used to estimate the reaction of the customer's actual skin. Therefore, according to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0042] The biological response of the three-dimensional skin tissue to be observed (the expression level of gene G in the above hypothetical example) is not particularly limited, as long as it is possible to observe whether or not there is a change in the response of the three-dimensional skin tissue when the candidate component is applied and / or the magnitude of the response. Examples of such characteristics include, but are not limited to, the physical properties of the three-dimensional skin tissue, the shape of the three-dimensional skin tissue, the presence or absence of aging-related substances, the amount of aging-related substances present, the presence or absence of expression of specific genes, the expression amount of specific genes, the amount of specific proteins present, the localization of specific proteins, or the presence or absence of inflammatory reactions.

[0043] The physical properties of three-dimensional skin tissue include, for example, the elasticity, tension, and viscoelasticity of the three-dimensional skin tissue, the structure and density of the skin such as cells and retinaculum, the coefficient of surface friction, the surface pH, the barrier function, and the amount of water evaporation. The shape of the three-dimensional skin tissue can be exemplified by the oblateness, the number of skin appendages, the thickness of the cell layer, or the presence or absence of formation of interpapillary processes or the number thereof. Examples of aging-related substances include advanced glycation endproducts (AGEs) and methylated histones.

[0044] The specific gene is preferably a gene associated with aging phenomena such as age spots and wrinkles, etc. Examples of the specific gene include, but are not limited to, TYRP1, TYR, SCF, KGF, c-kit, TRP1, MMP, OPA1, RGMB, DDIT3, FGF21, IGFBP2, GDF11, QSOX1, RBMS3, ZO-1, COL, ELN, and FBN. The specific protein is preferably a protein associated with aging phenomena such as age spots and wrinkles, etc. Examples include, but are not limited to, collagen, elastin, laminin, fibrin, leptin, tyrosinase, and proteinase.

[0045] The presence or absence of an inflammatory reaction can be measured by, for example, but not limited to, the amount of cytokines present.

[0046] The physical properties of the three-dimensional skin tissue, the shape of the three-dimensional skin tissue, the presence or absence of aging-related substances, the amount of aging-related substances present, the presence or absence of expression of specific genes, the expression amount of specific genes, the amount of presence of specific proteins, the localization of specific proteins, or the presence or absence of inflammatory reactions can be measured using known equipment and / or methods as appropriate.

[0047] Whether or not a candidate ingredient is an ingredient that can improve a customer's skin condition can be screened by setting appropriate evaluation indices based on the relationship between the skin condition to be improved and the biological reactions related to that skin condition.

[0048] In addition, the screening result receiving means 12 may receive the measurement values ​​themselves related to the above-mentioned biological reactions as screening results, or may receive images and / or video images of the biological reactions when the candidate component is applied to three-dimensional skin tissue as screening results.

[0049] The relationship between the improved skin condition and the biological response associated with the skin condition will be explained with reference to the hypothetical example. For example, in the hypothetical example, the skin condition is assumed to be "wrinkle formation." That is, let us focus on evaluation item X in the hypothetical example. In this case, improvement in skin condition can be defined as "inhibition of wrinkle formation" or "reduction in the amount of wrinkles per unit area." In the above hypothetical example, an increase in the expression level of gene G promotes wrinkle formation, so the biological response of "expression level of gene G" can be used as an evaluation index. In the above hypothetical example, three-dimensional skin tissue prepared from customer-derived cells was cultured for an appropriate period of time in the presence of candidate component A, and as a result, the expression level of gene G in the three-dimensional skin tissue decreased, so candidate component A can be evaluated as exhibiting effectiveness using evaluation index X. Therefore, candidate component A can be evaluated as an component that can suppress wrinkle formation and improve skin condition. In contrast, in the above hypothetical case, three-dimensional skin tissue was cultured for an appropriate period of time in the presence of each of candidate components B to D, and as a result, the expression level of gene G in the three-dimensional skin tissue did not change or did not increase, so candidate components B to D can be evaluated as not exhibiting effectiveness in terms of evaluation index X. In other words, candidate components B to D can be evaluated as not being components that can suppress wrinkle formation and improve skin condition. The type of biological reaction that must occur for a component to be evaluated as capable of improving skin condition can be determined appropriately depending on the relationship between the biological reaction and the skin condition.

[0050] Candidate components of cosmetics to be screened are not particularly limited, and examples thereof include commercially available compounds, known compounds, extracts derived from animals and plants, etc. Extracts derived from animals and plants may be those that have been fractionated, purified, solvent removed, etc. Furthermore, extracts derived from plants include extracts using wild-growing or cultivated plants, extracts sold as raw materials for herbal medicines, etc., and commercially available extracts. Furthermore, the culture conditions used for screening, such as the culture medium, culture temperature, and culture period, can be set appropriately with reference to known conditions to suit the three-dimensional skin tissue to be used.

[0051] In the above hypothetical example, the biological response of each of the multiple candidate components A to D when applied to three-dimensional skin tissue was evaluated, but the biological response of a combination of two or more components when applied to three-dimensional skin tissue may also be evaluated. In other words, the screening in the present invention may involve selecting one component from a plurality of candidate components that can improve the skin condition of a customer, or may involve selecting a combination of two or more components from a plurality of candidate components that can improve the skin condition of a customer.

[0052] The screening may also be for selecting a physical stimulus suitable for the customer instead of or in addition to an ingredient capable of improving the customer's skin condition, or for selecting a physical stimulus that enhances the skin condition-improving effect of the ingredient in addition to an ingredient capable of improving the customer's skin condition. Examples of physical stimuli include, but are not limited to, irradiation with light of a specific wavelength, sound waves, ultrasound, radio waves, or radiation, application of vibrations at a specific frequency, application of pressure, heating or cooling, changes in oxygen, carbon dioxide, or nitrogen concentration, or application of electromagnetic waves or magnetic fields.

[0053] When selecting a physical stimulus suitable for a customer in screening, for example, the physical stimulus is applied to a three-dimensional skin tissue prepared from cells derived from the customer, and the biological response of the three-dimensional skin tissue is observed. The biological reaction to be observed is not particularly limited as long as it allows observation of the presence or absence of a change in the reaction of the three-dimensional skin tissue when a physical stimulus is applied and / or the magnitude of the reaction, such as the physical properties of the three-dimensional skin tissue, the shape of the three-dimensional skin tissue, the presence or absence of aging-related substances, the amount of aging-related substances present, the presence or absence of expression of a specific gene, the expression amount of a specific gene, the amount of presence of a specific protein, the localization of a specific protein, or the presence or absence of an inflammatory reaction.

[0054] In addition, when selecting a physical stimulus that is suitable for a customer, only the candidate physical stimulus may be applied to the cultured three-dimensional skin tissue, or both the candidate component and the physical stimulus may be applied. When only the candidate physical stimuli are applied to the three-dimensional skin tissue, it is possible to select the physical stimuli that can improve the skin condition of the customer. When both the candidate ingredient and the candidate physical stimulus are applied to the three-dimensional skin tissue, an ingredient that can improve the skin condition of the customer and a physical stimulus that can enhance the effect of the ingredient can be selected.

[0055] The three-dimensional skin tissue is not particularly limited as long as it is produced from cells derived from the customer, but is preferably a skin organoid. Unlike simple cell masses, skin organoids are tissues that function as skin. In other words, skin organoids created from cells derived from a customer have the characteristics of the customer's actual skin and also function as skin. Therefore, the response of skin organoids to chemicals, etc. is expected to be the same as the response of the customer's actual skin, or at least a response that can be estimated from the response of the customer's actual skin. Therefore, according to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0056] The skin organoids are produced from cells derived from a customer, and their morphology is not particularly limited as long as they have at least an epidermal layer and a dermal layer. In addition to the epidermal layer and the dermal layer, they may also have skin appendages such as sweat glands, sebaceous glands, hair follicles, and hair. In addition, the skin organoid may be a spherical skin organoid, or may be a layered skin organoid in which the epidermis layer and the dermis layer are stacked.Preferably, the skin organoid is a layered skin organoid in which the epidermis layer and the dermis layer are stacked.

[0057] Skin organoids can be produced by any known method, including from pluripotent stem cells such as induced pluripotent stem cells (iPS cells) and embryonic stem cells (ES cells), as well as somatic stem cells.

[0058] Induced pluripotent stem cells can be induced by any known method. The somatic cells from which they are derived can be used without any particular limitation as long as they are derived from a customer. Preferably, the induced pluripotent stem cells are derived from somatic cells collected from a client's biological sample. More preferably, induced pluripotent stem cells are derived from somatic cells collected from the customer's urine (urine-derived cells), from somatic cells collected from hair (keratinocytes), or from somatic cells collected from the skin. For collecting cells from urine, hair, or skin, any known method can be used as appropriate.

[0059] Somatic stem cells include mesenchymal stem cells, hematopoietic stem cells, neural stem cells, bone marrow stem cells, and germline stem cells.

[0060] In a preferred embodiment of the present invention, the skin organoids are prepared from induced pluripotent stem cells derived from a customer. Specifically, the skin organoids are prepared by collecting somatic cells from a biological sample derived from the customer, inducing iPS cells from the collected somatic cells, and using the induced iPS cells. As described above, skin organoids created from cells derived from a customer have the characteristics of the customer's actual skin and also function as skin. Therefore, it is expected that the response of skin organoids to chemicals, etc. will be the same as the response of the customer's actual skin, or at least a response that can be estimated from the response of the customer's actual skin. Therefore, according to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0061] In a preferred embodiment of the present invention, screening involves applying a candidate component to a three-dimensional skin tissue prepared from cells derived from a customer in the presence of a biological sample derived from the customer. Three-dimensional skin tissue created from cells derived from a customer has the characteristics of the customer's skin, such as their skin type, constitution, and reaction to chemicals, but it also contains tissues that the three-dimensional skin tissue does not have, such as immune cells and blood. Therefore, by applying candidate ingredients to three-dimensional skin tissue created from cells derived from a customer in the presence of immune cells, blood, and other tissues not present in three-dimensional skin tissue, screening can be performed in an environment closer to that inside the customer's body, allowing for the proposal of more personalized cosmetics.

[0062] In a preferred embodiment of the present invention, screening is performed using a three-dimensional skin tissue prepared from cells derived from a customer and reflecting the customer's current skin condition. It is conceivable that the customer's skin condition may improve and become different from the initial skin condition as a result of continued use of the recommended cosmetics. For example, a customer who had skin with many wrinkles may find that the number of wrinkles decreases as a result of continued use of the recommended cosmetics. In this case, since the physical properties of the customer's skin and the amount of various components present have changed, by using three-dimensional skin tissue that reflects the current skin condition after the change in screening, it is possible to suggest cosmetics that are suitable for the current skin condition. Therefore, according to the present invention, by using three-dimensional skin tissue that reflects the (current) skin condition after changes due to the use of cosmetics, it is possible to propose more personalized cosmetics that respond to changes in the customer's skin condition.

[0063] The user terminal 2 is a terminal device connected to the server device 1 via the network NW and used by a user. The user terminal 2 can be any computer device such as a PC (Personal Computer) equipped with various input / output devices including a calculation device, a storage device, and a means for connecting to the network NW. Alternatively, a smartphone or a tablet terminal can be used as the user terminal 2. Dedicated applications for inputting and transmitting various information to and from the server device 1, a browser application for accessing dedicated web pages, etc. are stored in the storage device, and the calculation device executes various processes, allowing any computer device to function as the user terminal 2 of the present invention. The user terminal 2 is equipped with input means 21 such as a touch panel display, microphone, keyboard, etc., and display means 22 such as a display device.

[0064] A method for suggesting cosmetics using the cosmetics suggestion system according to this embodiment will be described with reference to FIG. First, in step S1, the customer information receiving means 11 receives customer information.

[0065] The customer information is not particularly limited as long as it is information about a customer to whom the cosmetic product is being proposed. For example, the customer information may include the customer's name, age, sex, place of residence, occupation, place of work, medical history, lifestyle habits, beauty habits, personality assessment results, blood test results, biopsy, skin condition information that indicates the state of the skin, ideal skin condition, etc. Furthermore, as in another embodiment described below, if an identifier that can uniquely identify the customer is assigned to the customer, the customer information may include the identifier. The customer information preferably includes at least information (such as name) that can uniquely identify the customer.

[0066] The customer information may be input by the user via the input means 21 of the user terminal 2. For example, a questionnaire or the like may be displayed on the display means 22, and the customer may input the customer information via the input means 21. Alternatively, for example, the cosmetic proposer may input customer information that he or she has previously acquired via the input means 21. Furthermore, for example, the customer and the cosmetic proposer may each input customer information via the input means 21. Alternatively, as in the embodiment described below, if the server device 1 has a storage means and customer information is pre-stored in the storage means, the customer information receiving means 11 may refer to the customer information received via the input means 21 of the user terminal 2 and the storage means to obtain the pre-stored customer information.

[0067] Preferably, the customer information includes skin condition information that is information representing the skin condition of the customer. Here, "skin condition" is not particularly limited as long as it is information that represents the customer's skin condition, and includes both subjective skin conditions obtained from questionnaire response results, etc., and objective skin conditions obtained from skin measurement data. The skin condition may be the skin condition of the face or the skin condition of the body other than the face. Furthermore, the facial skin condition may be the skin condition of the entire face, or may be the skin condition of a part of the face (for example, the cheeks, forehead, or around the eyes). Furthermore, the skin condition of the body other than the face may be the skin condition of each body part (for example, hands, arms, legs, etc.) or the tendency of the skin condition of the whole body (for example, prone to dryness overall, etc.).

[0068] The subjective skin condition is a qualitative skin condition (as perceived by the customer). Examples include, but are not limited to, the presence or absence of blemishes, wrinkles, sagging, firmness, elasticity, dullness, roughness, sensitivity, dryness, variations in these skin conditions for different parts of the face and / or body, or subjective changes in these skin conditions over time. The subjective skin condition may also be referred to as skin concerns. The objective skin condition is a quantitative skin condition. Examples include, but are not limited to, the number of blemishes per unit area, the darkness of blemishes, the amount of melanin per unit area, the distribution of melanin, the number of wrinkles per unit area, the wrinkle depth, the wrinkle density per unit area, the viscoelasticity of the skin, the shape of the skin texture, the skin color, the moisture content, the amount of moisture evaporation, the standard deviation or magnitude of the values ​​representing these skin conditions, or the objective change over time of these skin conditions. In other words, the objective skin condition is skin measurement data.

[0069] The skin measurement data can be obtained using known devices and / or methods, for example, by image diagnosis using photographs and / or videos of the customer's skin, or by directly measuring the customer's skin using known devices. When skin measurement data is obtained by image diagnosis using photographs and / or videos of the customer's skin, the customer information may include photographs and / or videos of the customer's skin. The photographs and / or videos accepted by the customer information accepting means 11 may be subjected to processing such as trimming or clipping as necessary, and then used for image diagnosis using known equipment and / or methods. In this case, the photographs and / or videos of the customer's skin may be taken by the customer, or may be photographs and / or videos taken by the cosmetic provider at a store, etc. Furthermore, the photographs and / or videos of the customer's skin may be photographs of the customer's entire face, or may be a close-up of a part of the customer's face (e.g., cheeks, forehead, eyes, etc.). Furthermore, the photographs and / or videos of the customer's skin may be a close-up of a part of the customer's body (e.g., the back of the hand, arm, neck, etc.).

[0070] Furthermore, the customer information receiving means 11 may receive, as customer information, skin measurement data obtained by image diagnosis or direct skin measurement. Furthermore, as in the embodiment described below, if the server device 1 includes a storage means, photographs and / or moving images of the customer's skin, skin image diagnosis results, or skin measurement data may be stored in the storage means. In this case, the customer information receiving means 11 may refer to the storage means to acquire photographs and / or moving images of the customer's skin, skin image diagnosis results, or skin measurement data.

[0071] The ideal skin condition is the skin condition that the customer desires (hopes to have). For example, examples include no / few / inconspicuous wrinkles, no / few / inconspicuous blemishes, no sagging, firm, no dullness, smooth skin, etc.

[0072] In a preferred embodiment of the present invention, the customer information includes one or more pieces of information selected from the customer's medical history, lifestyle habits, and beauty habits. Even if an ingredient is determined to have the potential to improve a customer's skin condition as a result of screening using three-dimensional skin tissue, it may be contraindicated for inclusion in cosmetics or may be preferable to avoid depending on the customer's medical history. Also, depending on the customer's lifestyle and beauty habits, an ingredient determined to be second or lower in the screening results may be considered to be the most effective. Therefore, according to the present invention, it is possible to propose personalized cosmetics that are verified to be suitable for the customer.

[0073] In the present invention, "lifestyle habits" refers to all habits related to the customer's life. For example, the customer's lifestyle habits may include, but are not limited to, sleep time, outdoor activity time, dietary habits, exercise habits (frequency and duration of each exercise session), etc. "Beauty habits" refers to habits related to a customer's daily life, especially those habits that the customer engages in for beauty purposes. For example, a customer's beauty habits may include, but are not limited to, the frequency of skin care, skin care methods, the number of skin care products they normally use, the types of skin care products they normally use (lotion, emulsion, cream, serum, etc.), the active ingredients contained in the skin care products they normally use, exercise habits such as training at the gym, walking, and yoga, and the implementation of UV protection measures. Furthermore, for example, things that can be classified as either lifestyle habits or beauty habits, such as exercise habits, can be classified as either one based on the customer's subjective opinion. For example, if you go to the gym or walk for beauty reasons, these exercise habits would be classified as beauty habits. On the other hand, if you exercise simply out of necessity, such as walking to work, it would be classified as lifestyle habits.

[0074] Next, in step S2, the screening result receiving means 12 receives the screening results of candidate ingredients for the cosmetic material to be provided to the customer. The screening result receiving means may receive screening results input by the cosmetic provider via the input device 21 of the user terminal 2, or may receive screening results stored in the server device 1 in advance.

[0075] For example, in the above hypothetical example, the screening result receiving means 12 can receive, as the screening result, information (such as the name) of component A. In this case, the provider of the cosmetic enters information such as the name of component A via the input means 21 of the user terminal 2 (first receiving mode). That is, in one embodiment of the present invention, the screening result receiving means 12 may receive, as the screening result, information regarding ingredients that have been selected by the cosmetic provider in the screening and that may improve the skin condition of the customer (such as the ingredient name, raw materials containing the ingredient, and sales company). In this case, the screening result (information regarding ingredients that may improve the skin condition of the customer) is input by the cosmetic provider via the input device 21 of the user terminal 2.

[0076] In another embodiment, for example, the screening result receiving means 12 can receive, as screening results, information on each of the candidate components A to D and raw data on the expression level of the gene G when each candidate component is applied to three-dimensional skin tissue (i.e., information on the biological response). In this case, the cosmetic provider inputs, via the input means 21 of the user terminal 2, information such as the names of the components A to D and the raw data when each candidate component is applied (second receiving embodiment). That is, in another form of the present invention, the screening result receiving means 12 may receive, as screening results, information regarding the components used in the screening and information regarding the biological response when each component is applied to three-dimensional skin tissue.

[0077] In the second reception mode, when the screening is performed by the active ingredient determination means 13 by observing biological reactions in three-dimensional skin tissue and determining whether or not the candidate ingredient is effective for the evaluation index, the screening results may be stored in the server device 1 (or in a storage means, if provided). Alternatively, the screening results may be stored in a separate server device different from the server device 1. The screening results at this time are not particularly limited as long as they can be data that can be obtained using known devices and methods, such as image data or measurement data of fluorescence intensity. Preferably, when the screening is performed by the active ingredient determination means 13 by observing biological reactions in three-dimensional skin tissue and determining whether or not the candidate ingredient is effective against the evaluation index, the screening results are stored in the server device 1 (or in the storage means, if provided). In this case, the screening result receiving means 12 refers to the server device 1 (or storage means) or another server device and receives the screening result and / or the determination as an effective ingredient as the screening result (a preferred form of the second receiving form).

[0078] In yet another embodiment, the screening result receiving means 12 may receive information about component A and information that “component A is effective against wrinkles” (information about evaluation index X) as the screening result (third receiving embodiment). That is, in another form of the present invention, the screening result receiving means 12 may receive, as screening results, information regarding the components subjected to screening and information regarding the evaluation index when the components are applied to three-dimensional skin tissue, expressed in natural language.

[0079] Two or more of the first to third reception modes may be combined.

[0080] In the first and third reception forms, the screening result reception means 12 may receive, as the screening results, information on component A, information on the biological response when component A is applied to three-dimensional skin tissue and / or information on evaluation item X for component A, as well as information on components B to D, and information on each of the biological responses when components B to D are applied to three-dimensional skin tissue and / or information on evaluation item X for components B to D. That is, in yet another embodiment of the present invention, the screening results received by the screening result receiving means 12 may include information on ingredients that were not evaluated as having the potential to improve the skin condition of the customer.

[0081] As described above, the screening results received by the screening result receiving means 12 include at least information on the candidate components subjected to screening. Examples of component information include, but are not limited to, the component name, raw materials, distributor, place of origin, and corresponding biological reactions.

[0082] As described above, the screening results received by the screening result receiving means 12 may be measurement values ​​(numerical values) of biological reactions, images and / or video images of biological reactions, or data entered in a natural language such as Japanese.

[0083] The above describes a form in which screening results are accepted for one evaluation item (evaluation item X), but it is also possible to screen two or more evaluation items (evaluation items X, Y, and Z in the hypothetical case) in parallel and accept screening results for each. That is, in the first to third reception forms, the screening results for each of a plurality of evaluation items may be received.

[0084] Next, in step S3, the active ingredient determining means 13 determines the active ingredients of the cosmetic that are suitable for the customer based on the screening results received by the screening result receiving means 12. There are no particular limitations on the method for determining the active ingredients of the cosmetic that suit the customer based on the screening results. According to the present invention, it is possible to propose cosmetics that have been verified to be suitable for the customer.

[0085] Specifically, for example, in the case of the first reception form described above, the active ingredient determination means 13 refers to the screening results received by the screening result reception means 12 and determines ingredient A as the active ingredient of the cosmetic suitable for the customer. That is, the active ingredient determining means 13 refers to the information on the ingredients contained in the screening results received by the screening result receiving means 12, and determines the ingredients as active ingredients of the cosmetics that suit the customer. If the screening results include information on ingredients that are not judged to be capable of improving the customer's skin concerns, the active ingredient determination means 13 selects ingredients that are capable of improving the customer's skin concerns and determines the active ingredients of the cosmetics that are suitable for the customer.

[0086] For example, in the case of the second reception form described above, in a hypothetical example, the active ingredient determination means 13 refers to the screening results (raw data or screening results stored in advance in the server device 1, etc.) received by the screening result reception means 12, selects the component A with the highest effectiveness for the evaluation item X, and determines component A as the active ingredient. That is, the active ingredient determination means 13 refers to the screening results received by the screening result receiving means 12, selects the most effective ingredient, and determines the selected ingredient as the active ingredient of the cosmetic suitable for the customer.

[0087] In this case, the method by which the active ingredient determining means 13 determines the active ingredient is not particularly limited, and can be set appropriately depending on the biological reaction (evaluation index). In the above hypothetical case, the expression levels of gene G in the three-dimensional skin tissue when each component is applied, as received by the screening result receiving means 12, are compared, and component A with the lowest expression level is determined to be the active component suitable for the customer.

[0088] The active ingredient determination means 13 determines the active ingredients of the cosmetics that suit the customer based on the screening results received by the screening result receiving means 12, and can propose cosmetics that have been verified as being suitable for the customer.

[0089] In the case of the third reception form described above, the active ingredient determination means 13 refers to the information received by the screening result reception means 12 that "ingredient A is effective against wrinkles" and determines ingredient A as the active ingredient of the cosmetic suitable for the customer.

[0090] The active ingredient determination means 13 may determine one or more ingredients as active ingredients. When the active ingredient determination means 13 determines multiple active ingredients, the active ingredient determination means 13 may determine the active ingredients by ranking the multiple ingredients in descending order of their skin condition improvement effect based on the screening results received by the screening result receiving means 12, or may determine all ingredients as active ingredients without ranking them. Preferably, when there are multiple ingredients that can be selected as active ingredients based on the screening results received by the screening result receiving means 12, the active ingredient determining means 13 determines the active ingredient by ranking them in order of their effectiveness in improving skin condition based on the screening results received by the screening result receiving means 12.

[0091] In addition to the name of the active ingredient, the active ingredient determination means 13 may also determine the raw materials of the active ingredient, the place of origin of the raw materials, the formulation of the entire cosmetic containing the active ingredient, or the name, form (cleansing, facial wash, lotion, cream, etc.) or method of use (frequency of use, timing of use, etc.) of the cosmetic containing the active ingredient. In this case, for example, the server device 1 may be equipped with an active ingredient database that links together information such as the name of the active ingredient, raw materials, origin of the raw materials, name, form, and / or usage method of the cosmetic containing the active ingredient, and a means (not shown) for determining information on the cosmetic other than the active ingredient by referencing the database. Also, if the server device 1 is equipped with a storage means, the active ingredient database may be stored in the storage means.

[0092] Although not shown, the server device 1 may also have a means (accompanying information determination means) for determining information (accompanying information) other than information about the active ingredient, such as other ingredients that can be used in combination with the active ingredient or that are preferable to be used in combination with the active ingredient, or the name, form, or usage method of cosmetics containing such other ingredients. In this case, the server device 1 may be provided with an accompanying information database in which active ingredients are stored in association with other ingredients that can be used in combination with the active ingredients or that are preferably used in combination with the active ingredients. For example, the accompanying information determination means refers to the database based on information on one or more active ingredients determined by the active ingredient determination means 13, and determines other ingredients that can be used in combination with the active ingredient determined by the active ingredient determination means 13 or that are preferably used in combination with the active ingredient. Furthermore, as in a third embodiment described later, when the server device 1 includes a storage means, the accompanying information database may be stored in the storage means.

[0093] The accompanying information may be determined by taking into account the customer's preferences from the customer information. In this case, the customer information includes the customer's preferences. When the incidental information is determined taking into consideration the customer's preferences, the incidental information database stores the preferences in association with information on cosmetic ingredients that match the preferences. For example, if the incidental information database stores the preference "I like citrus scents" in association with "ingredients that have a citrus scent," and the customer information includes the preference information "I like citrus scents," the incidental information determination means may take into consideration the preference information included in the customer information and select other ingredients that can be used in combination with the active ingredient or that are preferable to be used in combination with the active ingredient from among ingredients that have a citrus scent.

[0094] In a preferred embodiment of the present invention, the active ingredient determination means 13 determines the active ingredients of the cosmetic based on the skin condition acquired by the customer information receiving means 11 in step S1 and the screening results received by the screening result receiving means 12 in step S2. In a more preferred embodiment of the present invention, the active ingredient determination means 13 determines an ingredient that improves the customer's skin condition as the active ingredient of the cosmetic based on the skin condition acquired by the customer information receiving means 11 and the screening results received by the screening result receiving means 12. According to the present invention, it is possible to propose cosmetics that have been verified to be compatible with the customer's skin and contain ingredients that improve the customer's skin condition.

[0095] In another preferred embodiment of the present invention, the active ingredient determination means 13 determines the active ingredient based on one or more pieces of information selected from the skin condition acquired by the customer information receiving means 11, the screening results received by the screening result receiving means 12, and the customer's medical history, lifestyle habits, and beauty habits acquired by the customer information receiving means 11. As mentioned above, depending on the customer's medical history, lifestyle, and beauty habits, there may be restrictions on what can be included in cosmetics, and the likelihood of success when used by the customer may vary. Therefore, according to this embodiment, whether or not a cosmetic product is suitable for a customer can be verified, and personalized cosmetics can be proposed.

[0096] In a preferred embodiment of the present invention, the active ingredient determining means 13 determines the active ingredient and the amount of the active ingredient to be blended in the cosmetic. It is more preferable that the amount of the active ingredient to be blended is determined based on the screening results received by the screening result receiving means 12. As mentioned above, depending on the customer's medical history, lifestyle, and beauty habits, there may be restrictions on what can be included in cosmetics, and the likelihood of success when used by the customer may vary. Therefore, according to this embodiment, it is possible to verify whether a cosmetic product is suitable for the customer and propose a personalized cosmetic product.

[0097] Finally, in step S4, the output means 14 links and outputs information on cosmetics suitable for the customer, including information on one or more active ingredients determined by the active ingredient determination means 13, with the customer information received in step S1 by the customer information receiving means 11. If the accompanying information has been determined, the output means 14 may link and output information on cosmetics suitable for the customer, the customer information, and the accompanying information. The information output by the output means 14 is displayed, for example, on the display device 22 of the user terminal 2. It may also be printed by a printing means (not shown) such as a printer.

[0098] The above system makes it possible to propose cosmetics that have been verified as suitable for a customer based on the results of screening using three-dimensional skin tissue created from cells derived from the customer.

[0099] Cosmetics suited to the customer can be sold based on the cosmetic information output by the system. Also, cosmetics can be prepared using known methods and known equipment based on the cosmetic information output by the system. Furthermore, the cosmetics recommended by the system can be provided to the customer in an appropriate manner, such as by mail or in-store.

[0100] The system of the present invention preferably includes a means for updating the determination criteria of the active ingredient of the active ingredient determination means 13. The means for updating the determination criteria updates the determination criteria of the active ingredient determination means 13 based on the screening results received by the screening result receiving means 12 and the evaluation of the proposed cosmetic by the customer received by the customer information receiving means 11. The criteria for determining the active ingredient may be updated for each individual customer or may be updated for the entire system. As mentioned above, even if the ingredients are the same, whether or not they are effective and to what extent they are effective can vary depending on the customer's constitution, medical history, habits, etc. Therefore, by updating the criteria for determining active ingredients by the active ingredient determination means to suit the customer based on the screening results and evaluations from customers who have actually used the proposed cosmetics, it is possible to propose more personalized cosmetics. Furthermore, by updating the criteria for determining active ingredients by the active ingredient determination means for the entire system according to the present invention based on evaluations from multiple customers, it is possible to propose cosmetics that are more suited to the customer.

[0101] When updating the criteria for determining active ingredients to suit an individual customer, there is no particular limitation as long as the proposed cosmetics are more personalized to the customer. Furthermore, when updating the criteria for determining active ingredients for the entire system, there is no particular limitation as long as the proposed cosmetics are more suited to the customer. For example, instead of determining the candidate ingredient that is most suitable for a particular customer as a result of screening as the active ingredient, the criteria for determining the active ingredient can be updated so that the top three candidate ingredients that are most suitable for that customer are determined to be the active ingredients. Furthermore, for example, if the results of screening and / or customer evaluation reveal that a certain active ingredient is particularly effective in a part of the set concentration range, the means for determining the active ingredient may be updated so that the screening results in that part of the concentration range are used to determine the active ingredient. In this case, the system according to the present invention may suggest to User 2 that the part of the concentration range be used in the next or subsequent screening.

[0102] <Second embodiment> The second embodiment will be described with reference to Figures 3 and 4. Description of parts common to the first embodiment may be omitted or simplified.

[0103] As shown in FIG. 3, in this embodiment, the server device 1 further includes a beauty regimen determining unit 15. The beauty regimen determining means 15 is a means for determining a beauty regimen that suits a customer.

[0104] A method for suggesting cosmetics using the cosmetics suggestion system according to this embodiment will be described with reference to FIG. The processes and preferred forms in steps S1 to S3 are the same as those in the first embodiment. In this embodiment, the customer information preferably includes skin condition information, and in particular, the skin condition information preferably includes skin measurement data.

[0105] In step S5, the beauty regimen determining means 15 determines a beauty regimen suitable for the customer based on the customer information received by the customer information receiving means 11 in step S1. Preferably, the beauty regimen determining means 15 determines a beauty regimen suitable for the customer based on the skin condition received by the customer information receiving means 11 in step S1.

[0106] There are no particular limitations on the method for determining a beauty treatment method suitable for a customer. For example, a database linking a specific skin condition with one or more beauty treatment methods that can improve that skin condition may be stored in advance in the server device 1, and the beauty treatment method suitable for the customer may be determined by referring to the database based on the customer information. For example, a database linking predetermined candidate ingredients with one or more beauty methods that can enhance the effects of the candidate ingredients is stored in advance in the server device 1, and the database can be referenced based on customer information to determine a beauty method that suits the customer. In addition, as in a third embodiment described later, if the server device 1 has a storage means, these databases may be stored in the storage means.

[0107] Furthermore, if physical stimuli suitable for the customer are selected during screening, in step S2, the screening result receiving means 12 receives the physical stimuli selected as suitable for the customer, and based on the received selection results, the beauty method that can provide the physical stimuli to the customer may be determined to be the beauty method suitable for the customer. According to the present invention, it is possible to propose cosmetics and beauty methods that have been verified to be suitable for the customer.

[0108] The cosmetic treatment suited to the customer determined by the cosmetic treatment determination means 15 is not particularly limited as long as it is suited to the customer, but is preferably a cosmetic treatment for improving the customer's skin condition. Alternatively, the cosmetic treatment suited to the customer is preferably a cosmetic treatment for enhancing the effects of an ingredient determined as an active ingredient in a cosmetic suitable for the customer. Furthermore, the cosmetic treatment suited to the customer is preferably a cosmetic treatment using an ingredient that can improve the customer's skin condition based on the screening results received by the screening result receiving means 12. The beauty treatment is preferably one or more selected from beauty-related experiences such as cosmetic medicine and beauty salons, or improvements or additions to beauty routines, but is not limited to these.

[0109] Finally, in step S6, the output means 14 links together the information on the cosmetics suitable for the customer determined by the active ingredient determination means 13 in step S3, the beauty method suitable for the customer determined by the beauty method determination means 15 in step S5, and the customer information received by the customer information receiving means 11 in step S1, and outputs the results. The information on cosmetics suitable for the customer, the format of output by the output means 14, and the preferred formats thereof are the same as those in the first embodiment.

[0110] <Third embodiment> A third embodiment of the present invention will be described with reference to Fig. 5. Description of parts common to the first and second embodiments may be omitted or simplified. The cosmetic suggestion system according to the third embodiment further includes a storage means 16. The storage means 16 stores corresponding active ingredient data in which the evaluation indexes used in the screening are linked to the active ingredients corresponding to the evaluation indexes.

[0111] The linking relationship between the evaluation index and the active ingredient is not particularly limited. For example, the evaluation index and the active ingredient may be linked one-to-one. Also, for example, multiple active ingredients may be linked to one evaluation index. Also, for example, one active ingredient may be linked to multiple evaluation indexes. Furthermore, an active ingredient linked to one evaluation index may be linked to another evaluation index.

[0112] Furthermore, evaluation indices and active ingredients may be stored in association with known relationships. Furthermore, if a new relationship between a new evaluation index and an active ingredient is revealed by the screening, the new relationship may be updated by the user inputting the new relationship via the input means 21 of the user terminal 2.

[0113] In this embodiment, the active ingredient determination means 13 refers to the corresponding active ingredient data in step S3 shown in Figures 2 and 4, and determines the active ingredient corresponding to the evaluation index that indicates effectiveness on the customer's skin, among the evaluation indexes observed in the screening, as the active ingredient of the cosmetic that is suitable for the customer. The implementation methods and preferred forms of the steps other than step S3 are the same as those of the first and second embodiments.

[0114] For example, suppose that an evaluation index "inhibition of expression of gene G" and an active ingredient "ingredient A" are linked and stored as corresponding active ingredient data. In this case, as in the second reception form described above, in step S2, the screening result reception means 12 receives information on components A to D and the expression level of gene G when each component is applied to three-dimensional skin tissue as the screening results. At this time, in step S3, the active ingredient determination means 13 refers to the corresponding active ingredient data of the evaluation index (expression level of gene G) that indicates effectiveness on the customer's skin observed in the screening, and determines ingredient A as the active ingredient of the cosmetic that is suitable for the customer.

[0115] In another example, the evaluation index "effective against wrinkles" and an active ingredient "ingredient A" are stored in association with each other as corresponding active ingredient data. In this case, like the third reception form described above, the screening result reception means 12 receives, in step S2, information on component A and the information that "component A is effective against wrinkles" as the screening results. At this time, in step S3, the active ingredient determination means 13 refers to the active ingredient data corresponding to the evaluation index (effectiveness against wrinkles) that indicates the effectiveness on the customer's skin observed in the screening, and determines ingredient A as the active ingredient of the cosmetic that is suitable for the customer.

[0116] In the above hypothetical example, ingredient A is the only active ingredient that corresponds to the evaluation index showing the effectiveness on the customer's skin, but as a result of screening, there may be multiple active ingredients that correspond to the evaluation index showing the effectiveness on the customer's skin. In this case, the active ingredient determination means 13 may determine all active ingredients corresponding to the evaluation indexes indicating the effectiveness on the customer's skin as the active ingredients of the cosmetic suitable for the customer, or may select one or more active ingredients from the active ingredients corresponding to the evaluation indexes indicating the effectiveness on the customer's skin as the active ingredients of the cosmetic suitable for the customer. In a preferred embodiment of the present invention, when there are multiple active ingredients corresponding to evaluation indices that indicate effectiveness on the customer's skin, the active ingredient determination means 13 determines at least one active ingredient as the active ingredient of the cosmetic that is suitable for the customer based on the screening results received by the screening result receiving means 12. According to the present invention, it is possible to propose cosmetics that suit the customer's skin.

[0117] When the active ingredient determination means 13 selects one active ingredient from a plurality of active ingredients corresponding to evaluation indices indicating effectiveness on the customer's skin and determines it as the active ingredient of the cosmetic suitable for the customer, it is preferable that the active ingredient determination means 13 refers to the screening results received by the screening result receiving means 12 and determines the ingredient that has been shown to be most effective on the customer's skin as the active ingredient of the cosmetic suitable for the customer. When the active ingredient determination means 13 refers to the screening results received by the screening result receiving means 12, selects two or more active ingredients from a plurality of active ingredients corresponding to evaluation indices indicating effectiveness on the customer's skin, and determines them as active ingredients of the cosmetic suitable for the customer, it is preferable that the active ingredients of the cosmetic suitable for the customer are determined in descending order of effectiveness on the customer's skin in the screening. According to the present invention, it is possible to propose cosmetics that are more suited to the customer's skin.

[0118] Furthermore, in the above hypothetical example, if a component other than component A (component E) is previously linked as an active ingredient to the evaluation index "inhibition of expression of gene G" or "effective against wrinkles," the active ingredient determination means 13 may determine component E, in addition to component A, as the active ingredient of the cosmetic suitable for the customer. In other words, if the referenced corresponding active ingredient data is linked to other active ingredients other than the active ingredient corresponding to the evaluation index that showed effectiveness on the customer's skin among the evaluation indexes observed in screening, the active ingredient determination means 13 may determine that in addition to the active ingredient corresponding to the evaluation index that showed effectiveness on the customer's skin, the other active ingredients are also active ingredients. According to the present invention, it is possible to propose a plurality of active ingredients for cosmetics that suit the customer.

[0119] In another embodiment, it is also preferable that the active ingredient determination means 13 selects an active ingredient of a cosmetic product suitable for the customer from a plurality of active ingredients based on the screening results received by the screening result receiving means 12 in step S2 and the customer information received by the customer information receiving means 11 in step S1. In this case, it is preferable that the customer information considered together with the screening results is at least one or more of the customer's medical history, lifestyle habits, and beauty habits selected from the customer information received by the customer information receiving means 11. According to this embodiment, it is possible to propose personalized cosmetics that are verified to be suitable for the customer and that take into consideration the customer's medical history, etc.

[0120] In a preferred embodiment of the present invention, the storage means 16 further stores data linking customer information with an identifier that can uniquely identify the customer. According to the present invention, customer information can be easily managed.

[0121] There are no particular limitations on the type of identifier, as long as it can uniquely identify a customer. For example, the identifier can be a character string that is uniquely assigned to a customer. For example, the identifier can be a character string that includes letters, numbers, symbols, or a combination of these. There are no particular limitations on the number of characters.

[0122] It is preferable that an identifier is automatically assigned when new customer information is accepted by the customer information accepting means 11. In the case where an identifier is automatically assigned in correspondence with new customer information, the server device 1 may be provided with an identifier assigning means (not shown). The identifier assigning means is a means for referencing the customer information accepted by the customer information accepting means 11 and existing customer information pre-stored in the storage means 16 to determine whether the accepted customer information is new, and if the customer information is new, generating a new identifier and storing it in the storage means 16 in association with the new customer information.

[0123] In a preferred embodiment of the present invention, an identification code corresponding to the identifier is attached to a container used to collect cells derived from a customer and / or a culture container used in the process of producing the three-dimensional skin tissue. When verifying whether a candidate ingredient is suitable for a customer, it is necessary to link customer information with the screening results using three-dimensional skin tissue created from cells derived from the customer. According to this embodiment, customer information can be linked to information on three-dimensional skin tissue created from cells derived from the customer, and can be easily managed. Furthermore, when there are multiple screening results, changes in the screening results can be easily compared.

[0124] The identification code may be the identifier itself or another symbol corresponding to the identifier. For example, a barcode or two-dimensional code may be adopted as the identification code, and the server device 1 may recognize the identifier by reading it with the input means of the user terminal 2. Furthermore, if the identifier itself is an identification code, the user can input the identifier via the input means 21 of the user terminal 2, for example, so that the server device 1 can recognize the identifier.

[0125] The container used to collect cells from a customer can be made of an appropriate material and have an appropriate shape to suit the biological sample used to collect the cells.

[0126] In a preferred embodiment of the present invention, the storage means 16 stores a customer identifier linked to storage intention information, which is information regarding consent to one or more processes selected from storage, storage period, and disposal of customer-derived cells and / or three-dimensional skin tissue created from customer-derived cells. The term "customer-derived cells" as used herein includes somatic cells, embryonic stem cells, somatic stem cells collected from the customer, and induced pluripotent stem cells induced from somatic cells collected from the customer's biological sample. From the standpoint of privacy, when storing customer-derived cells or three-dimensional skin tissue created from customer-derived cells, it is preferable to obtain consent from the customer in advance, including regarding the storage period and disposal time. Therefore, according to the present invention, the reliability and transparency of the system can be improved.

[0127] Consent to store customer-derived cells and / or three-dimensional skin tissue prepared from customer-derived cells is consent to the act of storage itself. Consent regarding the storage period of the customer-derived cells and / or the three-dimensional skin tissue prepared from the customer-derived cells means consent to storage for a predetermined period (e.g., 5 years from the preparation of the three-dimensional skin tissue). The storage period of the three-dimensional skin tissue may be selectable by the customer. Consent to discard the customer-derived cells and / or the three-dimensional skin tissue prepared from the customer-derived cells means consent to the disposal itself after the storage period has elapsed. The storage intention information is received by the customer information receiving means 11.

[0128] When acquiring storage intention information, it is preferable to acquire it at the first use of the system according to the present invention. Alternatively, the storage intention information may be acquired periodically. Furthermore, it is preferable to acquire storage intention information for the customer-derived cells and storage intention information for the three-dimensional skin tissue created from the customer-derived cells separately. In a preferred embodiment of the present invention, the storage intention information can be changed at any time according to the customer's wishes.

[0129] When acquiring storage intention information, the output means 14 may notify the customer when there is a change in the storage status, such as when storage begins, when the end of the storage period is approaching (for example, one month before the expiration date of the storage period), or when disposal is completed. The notification is preferably sent in a form that can be viewed only by the customer and the cosmetic provider, such as a personal page that can be viewed on the web or using a dedicated application. Furthermore, when a dedicated application is used, push notification may be sent.

[0130] Furthermore, the storage intention information may be information on storage intention for a biological sample derived from a customer. Furthermore, the storage intention information may include intentions regarding the use of the stored cells derived from the customer and the three-dimensional skin tissue created from the cells. For example, the consent may include whether the stored cells derived from the customer and the three-dimensional skin tissue created from those cells will be used only for proposing cosmetics using the system, or whether the consent is also given to their use for other purposes (such as basic research).

[0131] In a preferred embodiment of the present invention, the memory means 16 stores a customer identifier, culture conditions for three-dimensional skin tissue created from cells derived from the customer, conditions for conducting one or more previous screenings, and results of one or more previous screenings, all linked together. It is expected that the customer's skin condition will improve as a result of continued use of the proposed cosmetics. Therefore, it is preferable to conduct regular screening and change the cosmetic formulation in accordance with changes in skin condition in order to continuously improve the customer's skin condition. Furthermore, from the perspective of customer satisfaction, it is preferable to design the second and subsequent screenings based on the cell culture conditions and screening conditions used in the previous screenings, thereby shortening the time required to obtain screening results and shortening the time from receiving a customer's application to proposing a cosmetic product to the customer. Therefore, according to the present invention, it is possible to continuously recommend cosmetics based on the skin condition. Furthermore, according to the present invention, it is possible to shorten the time until the second or subsequent screening results are obtained, thereby improving the speed at which cosmetics can be recommended to customers.

[0132] Examples of culture conditions for three-dimensional skin tissues created from customer-derived cells include, but are not limited to, conditions for induction into induced pluripotent stem cells, the composition of the culture medium used to create three-dimensional skin tissues from customer-derived cells, the culture period, culture temperature, and cell number, as well as the composition of the culture medium, culture period, culture temperature, and cell number required for culturing to maintain the structure of the created three-dimensional skin tissue. Examples of conditions for conducting one or more previous screenings include, but are not limited to, the composition of the culture medium used in the screening, the culture time for the three-dimensional skin tissue, the culture temperature, and the amount of candidate component applied. Examples of the results of one or more previous screenings include, but are not limited to, the names of active ingredients that were determined to be suitable for the customer and their optimal concentrations, and the names of ingredients that were not determined to be suitable for the customer.

[0133] 2. Cosmetics proposal method The present invention also relates to a cosmetic product suggestion method. The cosmetic product suggestion method of the present invention includes a screening step of screening for active ingredients that improve the skin condition of a customer using three-dimensional skin tissue prepared from cells derived from the customer, and a cosmetic product suggestion step of suggesting cosmetics containing the active ingredients. According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer.

[0134] The items described in "1." above can be applied to the customer-derived cells, the method for producing three-dimensional tissues, the screening method, and their preferred forms.

[0135] The proposed cosmetic product is not particularly limited in other formulations or cosmetic form, as long as it contains at least the active ingredient screened in the screening process. In a preferred embodiment of the present invention, in addition to a cosmetic preparation containing an active ingredient, the present invention also proposes other ingredients that can be used in combination with the active ingredient or that are preferably used in combination with the active ingredient, or cosmetic preparations that contain the other ingredients.

[0136] A preferred embodiment of the present invention includes a sample collection step of collecting cells from a customer, and a three-dimensional skin tissue preparation step of preparing the three-dimensional skin tissue from the collected cells.

[0137] In the sample collection step, cells are collected from the customer. The method for collecting cells is not particularly limited, and the cosmetic provider may collect a biological sample such as hair, urine, or skin from a customer and then separate and collect cells from the collected biological sample. Alternatively, the customer may collect a biological sample such as hair themselves, seal the collected biological sample in a container previously provided by the cosmetic provider, and send it to the cosmetic provider by mail or the like, and the cosmetic provider may then separate and collect cells from the biological sample upon receiving it. The customer's biological sample is preferably hair, urine, or skin.

[0138] In the three-dimensional skin tissue preparation step, three-dimensional skin tissue is prepared from the collected cells of the customer. The method and preferred form of the three-dimensional skin tissue can be the same as those described in "1." above.

[0139] When the cosmetic product suggestion method of the present invention includes a sample collection step and a three-dimensional skin tissue preparation step, it is preferable to carry out the screening step using the three-dimensional skin tissue prepared in the three-dimensional skin tissue preparation step.

[0140] In a preferred embodiment of the present invention, the three-dimensional skin tissue is a skin organoid prepared from cells of a customer. According to the present invention, it is possible to propose cosmetics that have been verified as being suitable for the customer. The preferred form of the skin organoid can be the same as that described in "1." above.

[0141] In a preferred embodiment of the present invention, the cosmetic product suggestion step is carried out using the cosmetic product suggestion system described in "1." above. According to the present invention, cosmetics that have been verified as being suitable for a customer can be easily proposed. [Industrial Applicability]

[0142] The present invention can provide cosmetics that have been verified to be suitable for customers, and can also manufacture cosmetics that have been verified to be suitable for customers.

Claims

1. A cosmetic product suggestion system comprising a customer information receiving means, a screening result receiving means, an active ingredient determining means, and an output means, The customer information receiving means is a means for receiving customer information, which is information about a customer; the screening result receiving means is means for receiving the screening results of candidate ingredients for the cosmetic to be provided to the customer; the active ingredient determination means is means for determining an active ingredient of the cosmetic suitable for the customer based at least on the screening results, the output means outputs information about the cosmetics suitable for the customer, including information about the determined active ingredients, in association with the customer information received by the customer information receiving means; The screening is a cosmetic suggestion system in which the candidate ingredients are applied to three-dimensional skin tissue created from cells derived from the customer, and the biological response of the three-dimensional skin tissue is observed as an evaluation index to select ingredients that can improve the customer's skin condition.

2. The cosmetic suggestion system according to claim 1 , wherein the three-dimensional skin tissue is a skin organoid produced from cells derived from the customer.

3. the customer information includes skin condition information that is information representing the skin condition of the customer; The cosmetics suggestion system according to claim 1 , wherein the active ingredient determining means determines the active ingredients of the cosmetics that suit the customer based on the screening results and the skin condition.

4. The cosmetic suggestion system according to claim 3 , wherein the active ingredient is an ingredient that improves the skin condition.

5. The customer information further includes one or more pieces of information selected from the customer's medical history, lifestyle habits, and beauty habits; 4. The cosmetic recommendation system according to claim 3, wherein the active ingredient determination means determines the active ingredient based on at least the skin condition, the screening results, and one or more pieces of information selected from the customer's medical history, lifestyle habits, and beauty habits.

6. Further, a beauty treatment method determination unit is provided for determining a beauty treatment method suitable for the customer based on the customer information, The cosmetic recommendation system according to any one of claims 1 to 5, wherein the output means outputs information on cosmetics suitable for the customer and the determined beauty method suitable for the customer, linked to the customer information.

7. The cosmetic suggestion system according to claim 1 , further comprising: means for updating a determination criterion of the active ingredient determined by the active ingredient determining means based on the screening results and the evaluations of the cosmetic collected from the customers.

8. The cosmetic suggestion system according to claim 1 , wherein the active ingredient determination means determines the active ingredient and the amount of the active ingredient in the cosmetic that is suitable for the customer.

9. The cosmetic suggestion system according to claim 1 , wherein the screening comprises applying the candidate ingredient to the three-dimensional skin tissue prepared from cells derived from the customer in the presence of a biological sample derived from the customer.

10. The cosmetic product suggestion system according to claim 1 , wherein the screening is performed using three-dimensional skin tissue prepared from cells derived from the customer and reflecting the customer's current skin condition.

11. Further comprising a storage means, the storage means stores corresponding active ingredient data in which the evaluation index and the active ingredient corresponding to the evaluation index are linked; The cosmetic recommendation system according to claim 1, wherein the active ingredient determination means refers to the corresponding active ingredient data and determines, among the evaluation indices observed in the screening, the active ingredient corresponding to an evaluation index that indicates effectiveness on the customer's skin as the active ingredient of the cosmetic that is suitable for the customer.

12. The cosmetics suggestion system according to claim 11 , wherein the storage means further stores data linking the customer information with an identifier that can uniquely identify the customer.

13. The cosmetics suggestion system according to claim 12 , wherein the storage means further stores data linking the customer screening results with the customer's identifier.

14. The cosmetic suggestion system according to claim 11 or 12, wherein an identification code corresponding to the identifier is attached to a container used to collect the customer-derived cells and / or a culture container used in the process of creating the three-dimensional skin tissue.

15. The cosmetic suggestion system according to claim 13, wherein the storage means stores the customer's identifier in association with storage intention information, which is information regarding consent to one or more processes selected from storage, storage period, and disposal of cells derived from the customer and / or three-dimensional skin tissue created from cells derived from the customer.

16. The cosmetic suggestion system according to claim 13, wherein the storage means stores, in association with each other, an identifier of the customer, culture conditions for the three-dimensional skin tissue created from cells derived from the customer, conditions for implementing one or more previous screenings, and results of one or more previous screenings.

17. A screening step of screening for an active ingredient that improves the skin condition of the customer using a three-dimensional skin tissue prepared from cells derived from the customer; a cosmetic product proposing step of proposing a cosmetic product containing the active ingredient, A cosmetic suggestion method, wherein the cosmetic suggestion step is performed using the cosmetic suggestion system according to claim 1 .

18. Furthermore, a sample collection step of collecting cells from the customer; The cosmetic suggestion method according to claim 17, further comprising a three-dimensional skin tissue preparation step of preparing the three-dimensional skin tissue from the collected cells.

19. The cosmetic suggestion method according to claim 17 or 18, wherein the three-dimensional skin tissue is a skin organoid.

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