Microneedle manufacturing method

Abstract

One embodiment of the present invention provides a method for manufacturing microneedles, comprising the steps of applying a raw material containing a pharmacological ingredient to one or more recesses formed in a microneedle mold, and entering the microneedle mold with the applied raw material into a pressure chamber and pressurizing the raw material at the internal pressure of the pressure chamber to fill the raw material into the microstructures of the recesses, wherein the pressurizing step simultaneously injects and expels air into the pressure chamber, causing a convection phenomenon within the pressure chamber to simultaneously fill and dry the raw material.

Description

[Technical Field]

[0001] The present invention relates to a method for manufacturing a microneedle, and more particularly to a method for manufacturing a microneedle in which a pharmacological ingredient applied to a microneedle mold is simultaneously subjected to a pressurizing and drying process, thereby simplifying the process and improving the quantitative accuracy of the pharmacological ingredient. [Background technology]

[0002] Generally, microneedle dosage forms are intended to deliver ingredients to achieve a desired effect through the skin. Microneedle dosage forms use microneedles with a diameter and height of only tens to thousands of micrometers to penetrate the stratum corneum, which is the main barrier layer for ingredient delivery through the skin. The microneedles allow the target ingredients to reach the epidermis or dermis layer, and then exert their effects throughout the body through the area where the microneedles are applied or the circulatory system of the human body.

[0003] Microneedles can be broadly classified into metal microneedles and microneedles made of biodegradable materials.

[0004] Metal microneedles come in two types: hollow microneedles, which have a hollow space like a regular injection needle with a path through which the ingredients to be delivered can move, and solid microneedles, which deliver ingredients by coating them on the surface of the microneedle.

[0005] Meanwhile, biodegradable microneedles are mainly in the form of solid microneedles, and are prepared by coating the surface of the microneedle with an ingredient or forming the microneedle with a biodegradable polymer, applying it to the skin, and then delivering the ingredient as the applied microneedle decomposes. The biodegradable microneedles are generally manufactured by injecting the pharmacological ingredient that constitutes the microneedle into a mold inscribed with the shape of the microneedle.

[0006] At this time, as shown in FIG. 1, a conventional method for manufacturing biodegradable microneedles includes a process of applying a pharmacological component onto a mold, a process of infiltrating the pharmacological component into the microstructure inside the mold in a reduced pressure or vacuum environment, and a process of drying the pharmacological component inside the mold to form a microneedle.

[0007] However, such conventional methods for manufacturing biodegradable microneedles have the problem that quantitative deviation of the pharmacological ingredient in the microneedle can occur due to the phenomenon that the pharmacological ingredient and air bubbles in the mold escape during the decompression or vacuum process (the air bubbles burst and the pharmacological ingredient overflows into the mold indentation).

[0008] Prior art documents Korean Patent Registration No. 10-1747099 (2017.06.08) Summary of the Invention [Problem to be solved by the invention]

[0009] The present invention is intended to solve the problems of the prior art described above, and the object of the present invention is to provide a method for manufacturing microneedles that simplifies the process by simultaneously performing pressure and drying processes on a pharmacological ingredient applied to a microneedle mold, thereby improving the quantitative accuracy of the pharmacological ingredient. [Means for solving the problem]

[0010] In order to achieve the above object, one aspect of the present invention includes a step of applying a raw material containing a pharmacological ingredient to one or more recesses formed in a microneedle mold, and a step of inserting the applied raw material into a pressure chamber and pressurizing the raw material at an internal pressure of the pressure chamber to fill the raw material into the microstructures of the recesses. The pressurizing step includes simultaneously injecting and discharging air into the pressure chamber. flow The present invention provides a method for manufacturing microneedles, in which the filling and drying of the raw material are carried out simultaneously by causing a phenomenon.

[0011] In one embodiment of the present invention, the pressure of the air injected into the pressure chamber is X bar (X×10 5 Pa) and the pressure of the air discharged from the pressure chamber is Y bar (Y×10 5 Pa) When the internal pressure of the pressure chamber is XY bar, ((XY)×10 5 Pa) is 1.5 bar (1.5×10 5 Pa) The method for producing a microneedle may be characterized by the above.

[0012] In one embodiment of the present invention, the pressure of the air injected into the pressure chamber is 2 bar. (2×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 0.5 bar. (0.5×10 5 Pa) The method for producing a microneedle may be characterized by the above.

[0013] In one embodiment of the present invention, the microneedle manufacturing method may be characterized in that the microneedle mold is manufactured by injection molding a thermoplastic resin.

[0014] In one embodiment of the present invention, the method for manufacturing microneedles may be characterized in that the thermoplastic resin is at least one selected from the group consisting of polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polypropylene (PP).

[0015] In one embodiment of the present invention, the method for manufacturing microneedles may be characterized in that the recesses of the microneedle mold are tip recesses and exist independently of each other.

[0016] In order to achieve the above object, another aspect of the present invention includes the steps of placing a plurality of microneedle molds on a jig, applying a raw material containing a pharmacological ingredient to one or more recesses formed in the microneedle mold, fixing one or more of the jigs to a tray, and inserting the tray into a pressure chamber and pressurizing the raw material with an internal pressure of the pressure chamber to fill the raw material into the microstructures of the recesses, wherein the pressurizing step is performed by simultaneously injecting and discharging air into the pressure chamber. flow The present invention provides a method for manufacturing microneedles, in which the filling and drying of the raw material are carried out simultaneously by causing a phenomenon.

[0017] In one embodiment of the present invention, the pressure of the air injected into the pressure chamber is X bar (X×10 5 Pa) and the pressure of the air discharged from the pressure chamber is Y bar (Y×10 5 Pa) When the internal pressure of the pressure chamber is XY bar, ((XY)×10 5 Pa) is 1.5 bar (1.5×10 5 Pa) The method for producing a microneedle may be characterized by the above.

[0018] In one embodiment of the present invention, the pressure of the air injected into the pressure chamber is 2 bar. (2×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 0.5 bar. (0.5×10 5 Pa) The method for producing a microneedle may be characterized by the above. [Effects of the Invention]

[0019] According to one aspect of the present invention, the method for manufacturing microneedles of the present invention simplifies the process by simultaneously performing pressurization and drying processes in a pressure chamber on raw material applied to the recessed portion of a microneedle mold, thereby improving the quantitative accuracy of the raw material and reducing the possibility of contamination of the microneedles by reducing exposure to the external environment during the manufacturing process.

[0020] Furthermore, microneedles can be mass-formed in a pressurized chamber by using a jig on which a large number of microneedle molds can be placed and a tray on which a large number of jigs can be fixed, thereby improving the productivity of microneedles.

[0021] The effects of the present invention are not limited to the effects described above, but should be understood to include all effects that can be inferred from the configuration of the invention described in the detailed description of the present invention or the claims. [Brief explanation of the drawings]

[0022] [Figure 1] 1 is a diagram conceptually illustrating a method for manufacturing a microneedle according to the prior art. [Figure 2] 1 is a flowchart of a method for manufacturing a microneedle according to an embodiment of the present invention. [Figure 3] 1 is a conceptual diagram illustrating a method for manufacturing a microneedle in a case where a point application method is used within a recessed portion of a mold according to an embodiment of the present invention. [Figure 4] 1 is a conceptual diagram illustrating a method for manufacturing a microneedle in the case of a full mold coating method according to an embodiment of the present invention. [Figure 5] 10 is a flowchart of a method for manufacturing a microneedle according to another embodiment of the present invention. [Figure 6] 10 is a conceptual diagram illustrating a method for manufacturing a microneedle in a case where a point application method is used within a recessed portion of a mold according to another embodiment of the present invention. [Figure 7] 10 is a conceptual diagram illustrating a method for manufacturing a microneedle in the case of a full mold coating method according to another embodiment of the present invention. [Figure 8] An example will be given showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber. [Figure 9] An example will be given showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber. [Figure 10] An example will be given showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber. [Figure 11] An example will be given showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber. [Figure 12] An example will be given showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber. [Figure 13] An example will be given showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber. DETAILED DESCRIPTION OF THE INVENTION

[0023] The present invention will be described below with reference to the accompanying drawings. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. In order to clearly explain the present invention in the drawings, parts that are not relevant to the description are omitted, and similar parts are designated by similar reference numerals throughout the specification.

[0024] Throughout this specification, when a part is said to be "connected" to another part, this includes not only "directly connected" but also "indirectly connected" through another member in between. Furthermore, when a part is said to "include" some component, this does not mean that it excludes other components, but that it may further include other components, unless otherwise specified.

[0025] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0026] Figure 2 is a flowchart of a microneedle manufacturing method according to one embodiment of the present invention, Figure 3 is a conceptual diagram of a microneedle manufacturing method in the case of a point coating method within the recessed portion of a mold according to one embodiment of the present invention, and Figure 4 is a conceptual diagram of a microneedle manufacturing method in the case of a whole mold coating method according to one embodiment of the present invention.

[0027] 2 to 4, the method for manufacturing microneedles of the present invention includes a step of preparing a microneedle mold 100 (S110), a step of applying a raw material 120 to the engraved portion 110 of the microneedle mold 100 (S120), and a step of pressurizing, filling, and drying the raw material 120 in a pressure chamber 30 (S130).

[0028] More specifically, the method for manufacturing a microneedle of the present invention includes a step (S110) of preparing a microneedle mold 100, a step (S120) of applying a raw material 120 containing a pharmacological ingredient to one or more indentations 110 formed on the microneedle mold 100, and a step (S130) of inserting the microneedle mold 100 onto which the raw material 120 has been applied into a pressure chamber 30 and pressurizing the raw material 120 at the internal pressure of the pressure chamber 30 to fill the raw material 120 into the microstructures 111 of the indentations 110. The pressurizing step (S130) is carried out by simultaneously injecting and discharging air into and from the pressure chamber 30. flow The source material 120 is filled and dried simultaneously by causing a phenomenon.

[0029] In the step of preparing the microneedle mold 100 (S110), a thermoplastic resin is injection molded using an injection device through a process of melting, flowing, cooling, and demolding to manufacture the microneedle mold 100 having one or more recessed portions. At this time, one side of the microneedle mold 100 may include one or more recessed portions 110, and the other side may be flat. The recessed portions 110 act as a mold for the microneedles formed in the subsequent step, and may have the same shape as the microneedles.

[0030] In this case, the recessed portion 110 may include a pointed recessed portion. As used herein, the term "pointed recessed portion" refers to a recessed portion whose cross-sectional area decreases from a flat upper surface to a pointed lower surface, forming a typical microneedle shape. The terms "upper surface" and / or "lower surface" used herein are intended to specify the relative positional relationship of each component, but do not specify their absolute positions.

[0031] Meanwhile, the microneedle mold 100 may be made of a rigid material. The microneedle mold 100 may be made of any suitable material, but is preferably made of a plastic resin.

[0032] More specifically, the microneedle mold 100 may be made of at least one selected from the group consisting of polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polypropylene (PP), but is not limited thereto.

[0033] Conventional silicone materials are expensive, making them inconvenient to use as disposable materials and requiring reuse, but in this case, it is difficult to verify the cleaning validation (CV) of the micro-indented area where the microneedles are molded and the silicone permeability of cleaning solvents.In addition, silicone materials are physicochemically decomposed and have a relatively weak hardness, which makes it difficult to verify the generation of debris during the manufacturing or cleaning process and the lifespan of the silicone mold.

[0034] In addition, in the mold manufacturing method using silicone material, silicone cannot protect against external air or foreign substances, so the dried microneedles must be repackaged after being removed from the silicone mold. In this process, since it is practically difficult to individually and tightly pack the microneedles due to their minute size, the microneedles must be packaged in a pouch exposed to air or in a cap-like container.

[0035] The closure and stability of the packaging container are factors that have a significant impact on maintaining the quality of the internal medicine, so it is necessary to completely protect the internal microneedle medicine from physical and chemical deformation and deterioration through simulation of the final product transportation conditions and mechanical testing.

[0036] The microneedle mold 100 of the present invention can function as a primary packaging container that is completely attached to the microneedle, eliminating the need to remove and repackage the microneedle formed in the engraved portion 110, and can be configured in a form that can be removed before use. This simplifies the packaging process of the microneedle and makes it easier to maintain the quality of the microneedle.

[0037] In the step (S120) of applying the raw material 120 to the engraved portions 110 of the microneedle mold 100, the raw material 120 can be supplied from a storage tank to the microneedle mold 100 through a single discharge portion and applied to the engraved portions 110. However, the method of applying the raw material 120 is not limited thereto, and the raw material 120 may be applied to the engraved portions 110 through multiple discharge portions located adjacent to each of the multiple engraved portions 110, as needed.

[0038] 3 and 4, the application of the raw material 120 can be performed by applying one or more drops only to each of the recessed portions 110, or by applying the raw material 120 to the entire top surface of the microneedle mold 100 on which the recessed portions 110 are formed. Depending on the application of the microneedle, the raw material 120 may include one or more selected from the group consisting of metals, non-metals, biodegradable polymers, and active pharmaceutical ingredients. For example, the raw material 120 may be a composition containing a pharmacological ingredient, and may be, but is not limited to, a composition containing a metal, non-metal, biodegradable polymer, or a combination of two or more of these.

[0039] In the step (S130) of pressurizing the raw material 120 applied to the engraved portion 110 in the pressurizing chamber 30, the raw material 120 is pressurized using the internal pressure of the pressurizing chamber 30 in order to fill the raw material 120 into the microstructure 111 of the engraved portion 110.

[0040] When the pressure chamber 30 is sealed and air is injected through the inlet 31 of the pressure chamber 30 to increase the pressure in the pressure chamber 30, the raw material 120 is pressurized by the gas pressure inside the pressure chamber 30, and the microscopic bubbles contained in the raw material 120 are naturally removed from the raw material 120, and the raw material 120 fills the microstructure 111 in the engraved portion 110.

[0041] At this time, air is simultaneously discharged through the outlet 32 ​​of the pressurized chamber 30 to flow This allows the drying of the raw material 120 to be carried out at the same time.

[0042] That is, the microneedle manufacturing method of the present invention simplifies the process by simultaneously performing pressurization and drying processes in the pressurization chamber 30 on the raw material 120 applied to the engraved portion 110 of the microneedle mold 100, thereby improving the quantitative accuracy of the raw material 120 and reducing the possibility of contamination of the microneedles by reducing exposure to the external environment during the manufacturing process.

[0043] Meanwhile, the pressure of the air injected into the pressure chamber 30 through the inlet 31 is X bar. (X×10 5 Pa)and the pressure of the air discharged from the pressurized chamber 30 through the outlet 32 ​​is Y bar (Y×10 5 Pa) When the pressure inside the pressure chamber 30 is XY bar, ((XY)×10 5 Pa) is 1.5 bar (1.5×10 5 Pa) Above 2 bar, preferably (2×10 5 Pa) It could be more than that.

[0044] The pressure of the air injected into the pressure chamber 30 is 2 bar. (2×10 5 Pa) Above 2.5 bar, preferably 2.5 bar (2.5×10 5 Pa) The pressure of the air discharged from the pressure chamber 30 is 0.5 bar. (0.5×10 5 Pa) It could be more than that.

[0045] That is, the pressure chamber 30 is simultaneously inflated and deflated, but the internal pressure of the pressure chamber 30 is 1.5 bar. (1.5×10 5 Pa) Above 2 bar, preferably (2×10 5 Pa) The pressure inside the pressure chamber 30 is maintained at 1.5 bar or more, so that the filling and drying of the source material 120 can be smoothly performed. (1.5×10 5 Pa) If the temperature is less than this, the raw material 120 may not be smoothly filled into the microstructures 111 in the recessed portions 110, and the micro bubbles contained in the raw material 120 may not be naturally released from the raw material 120.

[0046] Figure 5 is a flowchart of a microneedle manufacturing method according to another embodiment of the present invention, Figure 6 is a conceptual diagram of a microneedle manufacturing method using a point coating method within the recessed portion of a mold according to another embodiment of the present invention, and Figure 7 is a conceptual diagram of a microneedle manufacturing method using a full mold coating method according to another embodiment of the present invention.

[0047] The following description will focus on differences or additions from the above-described embodiment.

[0048] 5 to 7, the method for manufacturing microneedles of the present invention includes a step of preparing a microneedle mold 100 (S210), a step of placing a plurality of microneedle molds 100 on a jig 10 (S220), a step of applying raw material 120 to the engraved portion 110 of the microneedle mold 100 (S230), a step of fixing one or more of the jigs 10 to a tray 20 (S240), and a step of inserting the tray 20 into a pressurizing chamber 30 and pressurizing the raw material 120 with the internal pressure of the pressurizing chamber 30 to fill the microstructures 111 of the engraved portion 110 with the raw material 120 (S250). The pressurizing step (S250) involves simultaneously injecting and discharging air into and from the pressurizing chamber 30. flow The chamber is configured to cause an event to occur and simultaneously perform filling and drying of the source material 120.

[0049] In the step (S220) of placing a number of microneedle molds 100 on the jig 10, the jig 10 may be formed in a plate shape and may have a number of mounting portions (not shown) on the upper surface on which the microneedle molds 100 can be positioned. The mounting portions may have a groove structure having a shape corresponding to the shape of the microneedle molds 100.

[0050] The jig 10 can be configured so that microneedle molds 100 can be placed in a form of N×M (where N and M are numbers), and a total of N×M microneedle molds 100 can be placed on one jig 10.

[0051] In the step (S230) of applying the raw material 120 to the engraved portions 110 of the microneedle mold 100, the raw material 120 can be supplied from a storage tank to the microneedle mold 100 through a single discharge portion and applied to the engraved portions 110. However, the method of applying the raw material 120 is not limited thereto, and the raw material 120 can be applied to the engraved portions 110 through multiple discharge portions located adjacent to each of the multiple engraved portions 110, as needed.

[0052] At this time, referring to Figures 6 and 7, the application of the raw material 120 can be performed by applying one or more drops only to each of the recessed portions 110, or by applying the raw material 120 to the entire top surface of the microneedle mold 100 on which the recessed portions 110 are formed.

[0053] In the step of fixing one or more jigs 10 to the tray 20 (S240), the tray 20 may be a multi-tiered tray, and multiple jigs 10 may be fixed in multiple tiers to one tray 20. Also, multiple jigs 10 may be fixed to one tier of the tray 20.

[0054] In this way, microneedles can be mass-formed within the pressurized chamber 30 by using a jig 10 on which a large number of microneedle molds 100 can be placed and a tray 20 on which a large number of jigs 10 can be fixed, thereby improving the productivity of microneedles.

[0055] 8 to 13 show examples showing whether or not microneedles are generated for each polymer depending on the internal pressure of the pressure chamber.

[0056] 8 to 13, four types of polymers, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyvinylpyrrolidone (PVP), and hyaluronic acid (HA), were used as raw materials, and the presence or absence of microneedle formation was measured for each polymer after pressurization and drying in a pressure chamber. The ideal maximum size of the microneedle is 650 μm, and the presence or absence of microneedle formation was determined based on whether a tip of the microneedle was formed and whether the size was 400 μm or more.

[0057] Referring to FIG. 8, the pressure of the air injected into the pressure chamber for the four types of polymers applied to the microneedle mold was 2 bar. (2×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 1 bar. (1×10 5 Pa) and the internal pressure of the pressure chamber is 1 bar. (1×10 5 Pa) The pressure and drying process was carried out for 48 hours in this environment. At this time, it was confirmed that the tips of the microneedles were formed for the four polymers, but that microneedles with a size of 400 μm or more were not formed.

[0058] Referring to FIG. 9, the pressure of the air injected into the pressure chamber for the four types of polymers applied to the microneedle mold was 3 bar. (3×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 1 bar. (1×10 5 Pa) and the internal pressure of the pressure chamber is 2 bar. (2×10 5 Pa)The pressure and drying process was carried out for 48 hours in this environment. At this time, it was confirmed that the polyvinyl alcohol (PVA) polymer produced microneedle tips and microneedles with a size of 400 μm or more, but that the remaining three polymers did not produce microneedles.

[0059] Referring to FIG. 10, the pressure of the air injected into the pressure chamber for the four types of polymers applied to the microneedle mold was 4 bar. (4×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 1 bar. (1×10 5 Pa) and the internal pressure of the pressure chamber is 3 bar. (3×10 5 Pa) The pressure and drying process was carried out for 48 hours in this environment. At this time, it was confirmed that the polyvinylpyrrolidone (PVP) polymer produced microneedle tips and microneedles with a size of 400 μm or more, but that the remaining three polymers did not produce microneedles.

[0060] Referring to FIG. 11, the pressure of the air injected into the pressure chamber for the four types of polymers applied to the microneedle mold was 5 bar. (5×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 1 bar. (1×10 5 Pa) and the internal pressure of the pressure chamber is 4 bar. (4×10 5 Pa) The pressure and drying process was carried out for 48 hours in this environment. At this time, it was confirmed that the tip of the microneedle was formed for all four polymers, and that the microneedle had a size of 400 μm or more.

[0061] Referring to FIG. 12, the pressure of the air injected into the pressure chamber for the four types of polymers applied to the microneedle mold was 6 bar. (6×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 1 bar. (1×10 5 Pa) and the internal pressure of the pressure chamber is 5 bar. (5×10 5 Pa) The pressure and drying process was carried out for 48 hours in this environment. At this time, it was confirmed that the tip of the microneedle was formed for all four polymers, and that the microneedle had a size of 400 μm or more.

[0062] Referring to FIG. 13, the pressure of the air injected into the pressure chamber for the four types of polymers applied to the microneedle mold was 7 bar. (7×10 5 Pa) and the pressure of the air discharged from the pressure chamber is 1 bar. (1×10 5 Pa) and the internal pressure of the pressure chamber is 6 bar. (6×10 5 Pa) The pressure and drying process was carried out for 48 hours in this environment. At this time, it was confirmed that the tip of the microneedle was formed for all four polymers, and that the microneedle had a size of 400 μm or more.

[0063] The above description of the present invention is for illustrative purposes only, and those skilled in the art will understand that the present invention can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. Therefore, the above-described embodiments should be understood to be illustrative in all respects and not restrictive. For example, each component described as a single component may be implemented in a distributed form, and similarly, each component described as a distributed component may be implemented in a combined form.

[0064] The scope of the present invention is defined by the claims that follow, and all modifications and variations that fall within the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention. [Explanation of symbols]

[0065] 100: Microneedle mold 110: Intaglio part 111: Microstructure 120: Raw materials 10: Jig 20: Tray 30: Pressure chamber 31: Inlet 32: Outlet

Claims

1. Applying a raw material containing an active ingredient to one or more recesses formed in the microneedle mold; Entering the microneedle mold coated with the raw material into a pressure chamber; and pressing the raw material with the internal pressure of the pressure chamber to fill the raw material into the microstructure of the engraved portion, and simultaneously drying the raw material; In the pressurizing and drying step, outside air is injected into the pressurized chamber and the air in the pressurized chamber is simultaneously exhausted to the outside, thereby generating an air flow; A method for manufacturing microneedles, wherein drying of the pressurized raw material is carried out by the air flow.

2. A microneedle manufacturing method as described in claim 1, characterized in that the microneedle mold is manufactured by injection molding a thermoplastic plastic resin.

3. A microneedle manufacturing method as described in claim 2, characterized in that the thermoplastic resin is at least one selected from the group consisting of polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polypropylene (PP).

4. A microneedle manufacturing method as described in claim 1, characterized in that the engraved portions of the microneedle mold are pointed engraved portions and exist independently of each other.

5. placing a number of microneedle molds on a jig; applying a raw material containing an active ingredient to one or more recesses formed in the microneedle mold; securing one or more of said fixtures to a tray; advancing the tray into a pressurized chamber; and pressing the raw material with the internal pressure of the pressure chamber to fill the raw material into the microstructure of the engraved portion, and simultaneously drying the raw material; In the pressurizing and drying step, outside air is injected into the pressurized chamber and the air in the pressurized chamber is simultaneously exhausted to the outside, thereby generating an air flow; A method for manufacturing microneedles, wherein drying of the pressurized raw material is carried out by the air flow.

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