Transdermal delivery patch and penetration enhancer patch assembly

Abstract

The present application relates to the technical field of microneedle transdermal drug delivery, and particularly relates to a transdermal drug delivery patch and a penetration promoting patch assembly. The transdermal drug delivery patch comprises a driving device, the driving device comprises an elastic air bag, a pressure generating unit and a pressure limiting valve, the pressure generating unit is connected with the elastic air bag, is used for increasing the internal air pressure of the elastic air bag and making the elastic air bag expand, the pressure limiting valve is arranged on the elastic air bag, and is opened only when the air pressure in the elastic air bag exceeds a threshold value, is used for reducing the internal air pressure of the elastic air bag and making the elastic air bag shrink; the patch further comprises a dredging device, the dredging device comprises a substrate, one side surface of the substrate is in contact with the elastic air bag, and a dredging unit capable of treating the skin is arranged on the other side surface of the substrate; the dredging unit can repeatedly touch the skin in the process that the elastic air bag repeatedly expands and shrinks. The present application can effectively improve the absorption effect of the skin on active ingredients, and simultaneously reduce the operation and learning difficulty.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of microneedle transdermal drug delivery, in particular to a transdermal drug delivery patch and a penetration promoting patch assembly. BACKGROUND

[0002] Microneedle transdermal drug delivery technology is a new type of transdermal drug delivery technology that has been vigorously developed and popularized in recent years. This technology uses nanocrystal patches to dredge the skin surface and form a drug delivery channel, allowing active ingredients on the skin surface to quickly penetrate into the body, thereby effectively improving the therapeutic effect. In the prior art in this technical field, common transdermal drug delivery devices include penetration promoting instruments, water light machines, etc. such as a nanocrystal patch penetration promoting instrument (application number: 2018101620207), a liquid quantitative delivery system (application number: 201610883875X), and a penetration promoting massage pen (application number: 2019224693804) granted by the Chinese Patent Office.

[0003] These devices include the following two main steps in specific use: 1. using the device to dredge the skin; 2. applying active ingredients to the skin surface. In actual use, there are many problems, such as: the drug delivery channel formed after the nanocrystal patch dredges the skin is difficult to observe with the naked eye, and users cannot accurately identify the area of the skin surface that has been dredged, resulting in a situation where the drug application area does not correspond to the dredged area, causing the drug to be unable to be fully absorbed, resulting in drug waste. In addition, since the dredged area is difficult to observe with the naked eye, users cannot accurately and fully dredge the affected area, which can cause uneven drug absorption and uneven nursing effects.

[0004] In addition, the existing microneedle transdermal drug delivery system uses skin dredging and drug application in separate steps, and during the drug absorption process, the drug delivery channel will gradually close, which will also affect the overall absorption effect; if the skin dredging operation is continuously performed while the drug is being applied, the user needs to hold the device for a long time and needs to evenly and regularly dredge the drug application area, which increases the learning difficulty for the user and makes it difficult to ensure the absorption effect. Therefore, the existing microneedle transdermal drug delivery system needs to be improved. SUMMARY

[0005] In order to solve the technical problems of the microneedle transdermal system, such as the non-correspondence between the medicine applying area and the dredging area during operation, the poor absorption effect of active ingredients, the inconvenient operation and the difficult learning, the present application provides a transdermal drug delivery patch. The transdermal drug delivery patch comprises a driving device, the driving device comprises an elastic air bag, a pressure generating unit and a pressure limiting valve, wherein the pressure generating unit is connected with the elastic air bag to increase the internal air pressure of the elastic air bag and make it expand, wherein the pressure limiting valve is arranged on the elastic air bag, and the pressure limiting valve is opened only when the air pressure in the elastic air bag exceeds a threshold value, to reduce the internal air pressure of the elastic air bag and make it shrink; a dredging device, the dredging device comprises a substrate, one side surface of the substrate is in contact with the elastic air bag, and a dredging unit capable of treating the skin is arranged on the other side surface of the substrate; the dredging unit can repeatedly touch the skin during the repeated expansion and shrinkage of the elastic air bag.

[0006] The above technical solutions are further explained as follows.

[0007] Pressure generating unit: the pressure generating unit refers to a device capable of increasing the internal air pressure of the elastic air bag. Specifically, it can be a gas generating structure, such as generating gas by chemical reaction to increase the internal air pressure of the elastic air bag, or it can be a mechanical structure to fill gas into the elastic air bag, or it can be a physical reaction to increase the internal air pressure of the elastic air bag. The arrangement position of the pressure generating unit is flexibly set, which can be arranged inside the elastic air bag, or arranged outside the elastic air bag and connected with the elastic air bag through a conduit, a cavity, etc.

[0008] Pressure limiting valve: the pressure limiting valve is a normally closed valve, when the internal air pressure of the elastic air bag is not greater than the threshold value, the pressure limiting valve always remains closed; when the internal air pressure of the elastic air bag is greater than the threshold value, the pressure limiting valve opens, the elastic air bag is connected with the outside world, and the air pressure is reduced. The pressure limiting valve can be a normally closed rubber valve, a normally closed silicone valve or other suitable structure.

[0009] The dredging unit repeatedly touches the skin: the "touching" action includes not only the contact between the dredging unit and the skin surface, but also the certain degree of skin surface indentation caused by the contact between the dredging unit and the skin surface; it also includes the insertion of the dredging unit into the skin surface to a certain depth, such as the insertion of the dredging unit into the stratum corneum of the skin.

[0010] The technical scheme of the present application increases the air pressure of the elastic air bag through the pressure generating unit, promotes the expansion of the elastic air bag, and then makes the dredging device close to the skin. When the air pressure inside the elastic air bag exceeds the threshold value, the pressure limiting valve opens, the gas inside the air bag is discharged from the pressure limiting valve, and then the elastic air bag shrinks and the internal air pressure decreases, and the dredging device moves away from the skin surface. As the internal air pressure of the elastic air bag decreases to less than the threshold value, the pressure limiting valve is closed. The pressure generating unit continues to work, and the elastic air bag is inflated again to enter the next movement cycle. Therefore, the design concept of the present application is to control the periodic expansion or shrinkage of the elastic air bag through the synergistic effect of the pressure generating unit and the pressure limiting valve, and then control the repeated touching of the dredging device on the skin. The dredging device touches the skin each time to dredge the skin.

[0011] The present application provides a technical scheme capable of automatically and continuously dredging the skin. Through automatic and continuous repeated touching, the skin can be continuously and evenly dredged, avoiding the disadvantages of user fatigue and difficulty in controlling the force. The present application can effectively ensure the absorption effect of active ingredients and reduce the operation difficulty of the user. The compact and delicate structure of the present application makes the transdermal drug delivery patch convenient and comfortable to arrange on the skin surface. It is worth emphasizing that the design of the elastic air bag can also play a buffering effect, making the touching of the dredging device on the skin softer and more comfortable, thereby improving the nursing experience.

[0012] In the preferred technical scheme, the pressure generating unit includes a controller, a gas generating agent and a gas generating cavity. The gas generating cavity is in communication with the elastic air bag through an exhaust port. The gas generating agent is arranged in the gas generating cavity and can be adjusted to start or stop reaction by the controller. In this preferred technical scheme, the gas generating cavity and the elastic air bag form an airtight space. When the gas generating agent generates gas or increases the air pressure in the airtight space, the elastic air bag will expand, and then drive the dredging device to close to and touch the skin surface. This preferred technical scheme provides a structure for automatically and continuously dredging the skin by the dredging device driven by the gas generated by physical or chemical methods. It is worth emphasizing that by using the gas generating agent instead of the traditional mechanical structure, the size of the transdermal drug delivery patch can be further reduced, making the transdermal drug delivery patch more convenient and comfortable to use, and more convenient to package and carry.

[0013] In the preferred technical solution, the gas generating agent comprises iron powder, and the controller comprises a control valve capable of adjusting the contact area of the iron powder with air. Through the above configuration, the iron powder can chemically react with air after being in contact with air and continuously generate heat, which can heat the air in the gas generating cavity and promote the elastic air bag to expand, thereby promoting the unclogging device to unclog the skin. Since the iron powder can continuously heat for a long time, the unclogging device can unclog the skin surface multiple times during the entire reaction process. In addition, the heat generated by the chemical reaction can heat the skin surface, thereby further improving the absorption effect of the skin on the active ingredients. The control valve can be a sealing film capable of being torn off and pasted, a sealing cover capable of controlling the size of the opening, or other suitable structures, which need not be specially limited here. When the sealing film or sealing cover is opened, the iron powder is in contact with air and generates heat, promoting the unclogging device to touch the skin; by closing the sealing film or sealing cover, the reaction process can be paused, thereby pausing the unclogging process of the skin.

[0014] In the preferred technical solution, the gas generating agent comprises hydrogen peroxide and a catalyst, and the controller comprises a separation structure capable of separating the hydrogen peroxide from the catalyst. Through the above configuration, the hydrogen peroxide can generate a large amount of oxygen after being in contact with the catalyst, which promotes the elastic air bag to expand, thereby promoting the unclogging device to reciprocatingly touch the skin. By controlling the type of catalyst or the amount of hydrogen peroxide and catalyst, the oxygen generation speed can be adjusted, thereby controlling the speed of the transdermal drug delivery patch in the unclogging process of the skin. This structure can be compared to a "water kettle that boils water", which continuously generates water vapor inside the kettle, causing the pressure-limiting valve to open and close continuously, and the internal pressure of the kettle periodically changes (the internal pressure of the elastic air bag periodically changes).

[0015] In the preferred technical solution, the gas generating agent comprises a condensate, and the controller comprises an electric heating control sheet in contact with the condensate. By heating the condensate with the electric heating control sheet, the condensate is vaporized, thereby increasing the internal pressure of the elastic air bag and achieving the unclogging process of the unclogging device on the skin. In this technical solution, by changing the power or power frequency of the electric heating control sheet, the speed and rhythm of gas generation can be controlled, thereby adjusting the unclogging mode of the unclogging device on the skin. The electric heating control sheet in this technical solution can also heat the skin, thereby improving the absorption effect of the skin on the active ingredients.

[0016] In the preferred technical solution, the pressure generating unit comprises an air pump and a controller, the air pump is in communication with the elastic air bag, and the controller can control the power of the air pump. In this technical solution, the inflation speed of the elastic air bag can be adjusted by controlling the inflation speed of the air pump, and the skin treatment mode of the skin treatment device can be adjusted. For example, the air pump intermittently fills the air, which promotes the intermittent inflation of the elastic air bag, and thus realizes the intermittent treatment of the skin treatment device on the skin.

[0017] In the preferred technical solution, the skin treatment unit comprises at least one of a micro-needle, a micro-blade, and a micro-protrusion.

[0018] In the preferred technical solution, the transdermal drug delivery patch further comprises a sticking structure, the sticking structure is arranged on the driving device, and the sticking structure can fix the transdermal drug delivery patch on the skin. The sticking structure can be a film containing a high molecular adhesive, transparent adhesive tape, etc. The transdermal drug delivery patch is fixed and arranged on the skin surface through the sticking structure. One of the optional use scenarios is that after the active ingredient is applied on the skin surface, the transdermal drug delivery patch is covered and fixed on the skin surface to realize continuous skin treatment, thereby improving the absorption effect of the skin on the active ingredient. It is easy to understand that the transdermal drug delivery patch can also be fixed and arranged on the skin surface by other suitable means.

[0019] In the preferred technical solution, the transdermal drug delivery patch further comprises a limiting portion, the surface of the limiting portion in contact with the skin forms a limiting surface; the skin treatment unit has an upper position and a lower position when repeatedly touching the skin, the upper position of the skin treatment unit is higher than the limiting surface, and the lower position of the skin treatment unit is not higher than the limiting surface. Through the above configuration, the limiting portion forms a stable limiting surface after contacting the skin surface, and the skin treatment device has a stable reference surface during the process of repeatedly touching the skin. When the skin treatment device is in the upper position, the skin treatment unit is higher than the limiting surface and does not contact the skin; when the skin treatment device is in the lower position, the skin treatment unit partially penetrates into the skin to treat the skin. Through the limiting portion structure, the skin treatment unit can repeatedly penetrate the skin, so that the skin can maintain a high permeability state, thereby ensuring the absorption effect of the skin on the active ingredient.

[0020] The application also provides a penetration promoting patch assembly, which comprises: a positioning patch capable of being fixed on the surface of the skin, the positioning patch having a positioning hole; and the transdermal administration patch according to any one of the above preferred technical solutions, wherein the size of the unblocking device on the transdermal administration patch is not greater than the size of the positioning hole, and the unblocking device is capable of repeatedly puncturing the skin exposed from the positioning hole. In this technical solution, the administration position is determined by the positioning patch, so that the user can intuitively and easily determine the position to be unblocked and administered, and after the administration position is determined, the transdermal administration patch is used to unblock and administer the specific position, so that the precise targeted administration can be realized. Through the above configuration, the transdermal administration patch can continuously unblock the specific position, so that the active ingredient can continuously and evenly penetrate into the skin, and the nursing and treatment effect is effectively improved.

[0021] In the preferred technical solution, the positioning patch has a sticking surface capable of being adhered to the skin and an assembling surface capable of cooperating with the transdermal administration patch, and the assembling surface and the transdermal administration patch are provided with a cooperation structure capable of being disassembled and assembled. The cooperation structure can be a buckle structure, a screw structure, a magnetic attraction structure, a magic tape structure or other suitable cooperation structures. Through the above configuration, when the positioning patch is attached to the affected area, the transdermal administration patch can be conveniently fixed to the affected area and continuously unblock the administration position.

[0022] In the preferred technical solution, the penetration promoting patch assembly further comprises an active ingredient capable of being absorbed by the skin. The active ingredient can comprise one or more of skin care products, biological agents and medical agents.

[0023] In the preferred technical solution, the active ingredient exists in one of a gel patch, a cream and a paste. BRIEF DESCRIPTION OF DRAWINGS

[0024] The preferred embodiments of the application will be described below with reference to the accompanying drawings, in which:

[0025] Figure 1 is a structural schematic view of embodiment one of the transdermal administration patch of the application;

[0026] Figure 2 is a structural schematic view of embodiment two of the transdermal administration patch of the application in an upper position;

[0027] Figure 3 is a structural schematic view of embodiment two of the transdermal administration patch of the application in a lower position;

[0028] Figure 4 is a structural schematic view of embodiment four of the transdermal administration patch of the application;

[0029] Figure 5 is a structural schematic diagram of a positioning patch in a penetration patch assembly of the present application.

[0030] List of reference signs:

[0031] A, transdermal administration patch; B, positioning patch; B1, positioning hole; 1, driving device; 11, pressure generating unit; 111, gas generating cavity; 1110, exhaust port; 112, gas generating agent; 113, controller; 114, air pump; 12, elastic air bag; 13, pressure limiting valve; 14, limiting part; 140, limiting surface; 15, adhesive film; 2, dredging device; 21, base; 22, dredging unit. DETAILED DESCRIPTION

[0032] The preferred embodiments of the present application will be described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present application, and are not intended to limit the protection scope of the present application.

[0033] It should be noted that in the description of the present application, the terms indicating the direction or positional relationship of "upper", "lower" and the like are based on the direction or positional relationship shown in the drawings, which is only for the convenience of description, and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0034] In addition, it should also be noted that in the description of the present application, unless otherwise explicitly specified and limited, the terms "assembly", "setting", "connection", "arrangement" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be directly connected, or indirectly connected through an intermediate medium, or it can be the internal communication of two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0035] In order to solve the technical problems of the microneedle transdermal system, such as the non-correspondence between the medicine applying area and the dredging area during operation, the poor absorption effect of active ingredients, the inconvenient operation and the high learning difficulty, the present application provides a transdermal drug delivery patch A. The transdermal drug delivery patch A comprises a driving device 1, the driving device 1 comprises an elastic air bag 12, a pressure generating unit 11 and a pressure limiting valve 13, wherein the pressure generating unit 11 is connected with the elastic air bag 12, so as to increase the internal air pressure of the elastic air bag 12 and make it expand, wherein the pressure limiting valve 13 is arranged on the elastic air bag 12, and the pressure limiting valve 13 is opened only when the air pressure in the elastic air bag 12 exceeds a threshold value, so as to reduce the internal air pressure of the elastic air bag 12 and make it shrink; a dredging device 2, the dredging device 2 comprises a substrate 21, one side surface of the substrate 21 is in contact with the elastic air bag 12, and a dredging unit 22 capable of treating the skin is arranged on the other side surface of the substrate 21; the dredging unit 22 can repeatedly touch the skin in the process of repeated expansion and shrinkage of the elastic air bag 12.

[0036] The technical scheme of the present application is further illustrated by examples.

[0037] Example one

[0038] Figure 1 is a structural schematic diagram of example one of the transdermal drug delivery patch of the present application. As Figure 1 shown, in the present example one, the driving device 1 is designed in a pie shape, which is relatively flat in the vertical dimension, so as to facilitate the application, carrying and packaging of the transdermal drug delivery patch A. The driving device 1 is provided with a sticking film 15 outside the half covering, and a sticking layer is provided at the lower surface of the sticking film 15, which faces the skin surface, so as to facilitate the arrangement and sticking of the transdermal drug delivery patch A on the skin surface. It should be noted that the sticking film 15 in the present example one can be a film containing a high molecular sticking agent. In addition to the sticking film, the transdermal drug delivery patch A can also be fixed on the skin surface in various other ways, such as baba, nano glue, transparent film, transparent adhesive tape, etc.

[0039] As Figure 1 shown, the driving device 1 comprises a pressure generating unit 11, an elastic air bag 12 and a pressure limiting valve 13. Among them, the pressure generating unit 11 is arranged above the elastic air bag 12. In the present example one, the pressure generating unit 11 comprises a gas generating cavity 111, a gas generating agent 112 and a controller 113. As Figure 1 shown, the gas generating cavity 111 is flat, the gas generating cavity 111 is communicated with the elastic air bag 12 through an exhaust port 1110, and the gas generating cavity 111 and the elastic air bag 12 form a gas-tight space in combination. The elastic air bag 12 can be made of silicone, rubber or other suitable materials.

[0040] As Figure 1As shown in the first embodiment, the gas generating agent 112 is arranged in the gas generating cavity 111. It is easily understood that the gas generating agent 112 can also be arranged outside the gas generating cavity 111, and the gas generated by the gas generating agent 112 is introduced into the gas generating cavity 111 through the gas guiding passage. In addition, the gas generating agent 112 can be directly communicated with the elastic air bag 12 through the gas guiding passage, so as to omit the structure of the gas generating cavity 111, and the gas generating agent 112 can be arranged inside or outside the elastic air bag 12. As shown in the first embodiment, Figure 1 As shown in the first embodiment, the controller 113 is exposed from the adhesive film 15, so as to facilitate the user to start or pause the reaction process of the gas generating agent 112.

[0041] As shown in the first embodiment, Figure 1 As shown in the first embodiment, one end of the pressure limiting valve 13 is connected with the elastic air bag 12, and the other end is exposed from the adhesive film 15. The pressure limiting valve 13 is a normally closed valve, which is always closed when the air pressure inside the elastic air bag 12 is not greater than a threshold value, and is opened when the air pressure inside the elastic air bag 12 is greater than the threshold value, so that the elastic air bag 12 is communicated with the outside, and the air pressure is reduced. The pressure limiting valve 13 can be a normally closed rubber valve, a normally closed silica gel valve or other suitable structure.

[0042] As shown in the first embodiment, Figure 1 As shown in the first embodiment, the unblocking device 2 is arranged below the elastic air bag 12. The base 21 of the unblocking device 2 is made of monocrystalline silicon material. Alternatively, the base 21 can also be made of metal or polymer material. As shown in the first embodiment, Figure 1 As shown in the first embodiment, the upper surface of the base 21 is attached with the lower wall of the elastic air bag 12. The unblocking unit 22 is arranged on the lower surface of the base 21. The unblocking unit 22 can be at least one of a micro-needle, a micro-blade and a micro-protrusion. The height dimension of the unblocking unit 22 is in micrometer level, and the tip dimension can reach nanometer level. The number of the unblocking unit 22 can be one or more. The unblocking unit 22 and the base 21 can be made of the same material or be heterojunctionally connected by different materials.

[0043] The transdermal drug delivery patch A in the first embodiment is attached to the skin surface through the adhesive film 15, and the dredging device 2 faces the skin surface. The dredging process can be realized by opening the controller 113. During the working process, the gas generating agent 112 promotes the increase of the air pressure in the gas generating cavity 111, and then increases the internal air pressure of the elastic air bag 12 and makes it expand, so as to drive the dredging device 2 to approach and touch the skin surface. When the air pressure in the elastic air bag 12 exceeds the threshold value, the pressure limiting valve 13 is opened, and the air pressure in the elastic air bag 12 is rapidly reduced, so that the elastic air bag 12 is reduced, and the dredging device 2 is away from the skin surface. With the decrease of the air pressure in the elastic air bag 12, the pressure limiting valve 13 is closed. The gas generating agent 112 continues to work, which will again promote the elastic air bag 12 to expand, and the dredging device 2 enters the next movement cycle. In the first embodiment, through the cooperation of the gas generating agent 112 and the pressure limiting valve 13, the elastic air bag 12 repeatedly expands and shrinks, which can drive the dredging device 2 to automatically and continuously dredge the skin.

[0044] The gas generating agent 112 has various forms. In the first embodiment, the gas generating agent 112 promotes the increase of the air pressure in the elastic air bag 12 through chemical reaction. The gas generating agent 112 specifically includes iron powder. Correspondingly, the controller 113 is a control valve capable of adjusting the contact area of the iron powder with the external air. Alternatively, the controller 113 is a sealing cover or sealing film capable of separating the iron powder from the external air. When the control valve is opened (the sealing cover or sealing film is opened), the iron powder contacts with the external air and reacts chemically, and heat is continuously generated during the reaction process, which can heat the gas generating cavity 111 and promote the expansion of the elastic air bag 12, and then promote the dredging of the skin by the dredging device 2. The user can adjust the opening size of the control valve to control the contact area of the iron powder with the air and the reaction speed, and then adjust the dredging speed of the dredging device 2. When the control valve is closed (the sealing cover or sealing film is closed), the iron powder is isolated from the external air, and the reaction of the gas generating agent 112 is suspended. Therefore, the user can suspend the dredging of the transdermal drug delivery patch A on the skin by the controller 113 in the middle of the operation, and continue to operate at a convenient time. It is worth noting that when the iron powder is selected as the gas generating agent 112, the heat generated during the reaction process can also heat the skin surface, which can further improve the absorption effect of the active ingredient on the skin surface.

[0045] Embodiment two

[0046] Figure 2 is a structural schematic view of the transdermal drug delivery patch of the present application in the upper position of the second embodiment; Figure 3 is a structural schematic view of the transdermal drug delivery patch of the present application in the lower position of the second embodiment. As Figure 2 and Figure 3As shown, unlike the first embodiment, in the second embodiment, the gas generating agent 112 includes hydrogen peroxide and a catalyst. Accordingly, the controller 113 is a separation structure capable of separating the hydrogen peroxide from the catalyst. As shown Figure 2 As shown, in the storage state, the separation structure separates the hydrogen peroxide and the catalyst from each other. By opening the separation structure through rotation, pressing or other suitable means, the hydrogen peroxide and the catalyst can be brought into contact, and the generation of gas can be started. As shown Figure 3 As shown, after the hydrogen peroxide and the catalyst are brought into contact, a large amount of oxygen is generated, which promotes the expansion of the elastic air bag 12, and in turn drives the unclogging device 2 to move downward and touch the skin surface. The gas generating agent 112 in the second embodiment can also promote the reciprocating touch of the unclogging device 2 to the skin in cooperation with the pressure-limiting valve 13.

[0047] It is worth noting that by controlling the type of catalyst or controlling the metering of hydrogen peroxide and catalyst, the oxygen generation speed can be adjusted, and in turn the unclogging processing speed of the transdermal drug delivery patch A to the skin can be controlled. This structure can be compared to a "water kettle with boiling water". The water kettle continuously generates water vapor inside, so that the pressure-limiting valve 13 continuously opens and closes, and the internal pressure of the water kettle periodically changes (the internal pressure of the elastic air bag 12 periodically changes, realizing repeated expansion and shrinkage).

[0048] Continuing to refer to Figure 2 and Figure 3 , in order to improve the unclogging processing effect of the unclogging device 2 to the skin, in the second embodiment, the transdermal drug delivery patch A also has a limiting portion 14. The limiting portion 14 is arranged below the pressure generating unit 11 and around the elastic air bag 12. Optionally, the limiting portion 14 is fixedly connected with the pressure generating unit 11. The adhesive film 15 is wrapped outside the limiting portion 14. As shown Figure 2 and Figure 3 As shown, the lower end surface of the limiting portion 14 faces the skin, and the surface of the lower end of the limiting portion 14 that can be in contact with the skin is defined as the limiting surface 140. During the working of the transdermal drug delivery patch A, the upper position and the lower position of the unclogging unit 22 will appear during the process of repeatedly piercing the skin, as shown Figure 2 As shown, the upper position of the unclogging unit 22 is higher than the limiting surface 140; as shown Figure 3 As shown, the lower position of the unclogging unit 22 is not higher than the limiting surface 140.

[0049] In the second embodiment, the position-limiting part 14 can ensure that the dredging unit 22 can leave the skin surface when it is in the upper position and be pulled out of the skin surface completely, and can effectively puncture the skin again when the dredging unit 22 moves downward from the upper position, so that the skin can be maintained in a high permeability state, and the absorption effect of the skin on the active ingredients can be ensured. It can be easily understood that the position-limiting part 14 can also have various other suitable structures and can be arranged at other suitable positions, as long as it can ensure that the dredging unit 22 can leave the skin surface when it is in the upper position.

[0050] Embodiment three

[0051] Unlike the second embodiment, in the third embodiment, the gas generating agent generates gas through a physical reaction. Optionally, the gas generating agent includes a condensate. The condensate can be water, ethanol, etc. Correspondingly, the controller includes an electrothermal control sheet in contact with the condensate. By heating the condensate through the electrothermal control sheet, the condensate can be vaporized, and the gas pressure inside the elastic air bag can be increased. By coordinating the gas generating agent with the pressure-limiting valve, the dredging device can also achieve the dredging process of the skin. It should be noted that in the third embodiment, by changing the power or power frequency of the electrothermal control sheet, the speed and rhythm of gas generation can be controlled, and the dredging mode of the dredging device on the skin can be adjusted. The electrothermal control sheet in this technical solution can also play a role in heating the skin, thereby improving the absorption effect of the skin on the active ingredients.

[0052] Embodiment four

[0053] Figure 4 is a structural schematic diagram of the fourth embodiment of the transdermal drug delivery patch of the present application. As shown in Figure 4 Unlike the second embodiment, in the fourth embodiment, the pressure generating unit 11 includes a gas generating cavity 111, a gas pump 114, and a controller 113. The gas generating cavity 111 is flat, the gas generating cavity 111 is in communication with the elastic air bag 12 through an exhaust port 1110, and the gas generating cavity 111 and the elastic air bag 12 form a gas-tight space in combination. The elastic air bag 12 can be silicone, rubber, or other suitable materials.

[0054] As shown in Figure 4 the exhaust end of the gas pump 114 is in communication with the gas generating cavity 111, and the air inlet end of the gas pump 114 is exposed from the adhesive film 15. The gas pump 114 is electrically connected with the controller 113, and in the fourth embodiment, the controller 113 is exposed from the adhesive film 15, so as to facilitate the control of the user.

[0055] It should be noted that in this embodiment four, the inflation speed of the elastic air bag 12 can be adjusted by controlling the inflation speed of the air pump 114, so as to adjust the skin treatment mode of the skin treatment device 2. For example, the air pump 114 can inflate intermittently, so as to make the elastic air bag 12 inflate intermittently, and thus the skin treatment device 2 can perform intermittent skin treatment.

[0056] It is worth emphasizing that in some embodiments, the exhaust end of the air pump 114 can be directly communicated with the elastic air bag 12, so as to omit the structure of the gas generating cavity 111, and thus the size of the transdermal drug delivery patch A is more slim and easy to carry.

[0057] The transdermal drug delivery patch A in the present application can also be combined with a positioning patch B to form a penetration patch assembly for precise targeted drug delivery. Figure 5 is a structural schematic view of the positioning patch in the penetration patch assembly of the present application. As shown in Figure 5 The outer peripheral size of the positioning patch B can be the same as or different from that of the transdermal drug delivery patch A, and the positioning patch B has a sticking surface capable of contacting the skin and an assembly surface matched with the transdermal drug delivery patch A. A positioning hole B1 is formed on the positioning patch B, and the size of the positioning hole B1 is not less than that of the skin treatment device 2. In use, the positioning patch B is first attached to the skin surface, the area to be treated is determined through the positioning hole B1, and then the transdermal drug delivery patch A is stacked on the positioning patch B, so that the skin treatment device 2 can be exposed from the positioning hole and repeatedly puncture the skin in the positioning hole.

[0058] When the transdermal drug delivery patch A has the structure of the sticking film 15, the transdermal drug delivery patch A can be adhered to the assembly surface of the positioning patch B through the sticking film. It is easily understood that the transdermal drug delivery patch A can also be relatively fixedly connected with the positioning patch B through other ways. For example, the assembly surface and the transdermal drug delivery patch A are provided with detachable and assemblable alignment structures, which can include buckle structures, screw structures, magnetic attraction structures, magic tape structures, etc., and the alignment structures can also realize the alignment, mounting and fixing between the transdermal drug delivery patch A and the positioning patch B.

[0059] Before, after or during the puncture of the skin treatment device 2, the active ingredient can be applied to the skin in the positioning hole B1, so as to effectively improve the absorption efficiency of the active ingredient. The active ingredient can include one or more of skin care products, biological agents and medical agents, and the preparation type of the active ingredient can be a gel patch, milk, cream, etc.

[0060] The technical scheme of the present application has been described in combination with the preferred embodiments shown in the drawings, but it is easy for those skilled in the art to understand that the protection scope of the present application is obviously not limited to these specific embodiments. Those skilled in the art can make equivalent changes or replacements to the related technical features without departing from the principles of the present application, and the technical schemes after the changes or replacements will all fall within the protection scope of the present application.

Claims

1. A transdermal drug delivery patch, characterized in that, The transdermal drug delivery patch includes: The drive unit includes an elastic airbag, a pressure generating unit, and a pressure limiting valve. The pressure generating unit is connected to the elastic airbag to increase the internal air pressure of the elastic airbag and cause it to inflate. The pressure limiting valve is disposed on the elastic airbag, and the pressure limiting valve is opened only when the air pressure inside the elastic airbag exceeds a threshold, so as to reduce the internal air pressure of the elastic airbag and shrink it. A drainage device, comprising a base, one side surface of which contacts the elastic airbag, and drainage units capable of treating the skin arranged on the other side surface of the base; The unblocking unit can repeatedly touch the skin as the elastic airbag expands and contracts.

2. The transdermal drug delivery patch according to claim 1, characterized in that, The pressure generating unit includes a controller, a gas generating agent, and a gas generating chamber. The gas generating chamber is connected to the elastic airbag through an exhaust port. The gas generating agent is disposed in the gas generating chamber and the reaction can be started and stopped by the controller.

3. The transdermal drug delivery patch according to claim 2, characterized in that, The gas generating agent includes iron powder, and the controller includes a control valve capable of adjusting the contact area between the iron powder and the air.

4. The transdermal drug delivery patch according to claim 2, characterized in that, The gas generating agent includes hydrogen peroxide and a catalyst, and the controller includes a separation structure capable of separating the hydrogen peroxide from the catalyst.

5. The transdermal drug delivery patch according to claim 2, characterized in that, The gas generating agent includes a condensate, and the controller includes an electrothermal control plate in contact with the condensate.

6. The transdermal drug delivery patch according to claim 1, characterized in that, The pressure generating unit includes an air pump and a controller. The air pump is connected to the elastic airbag, and the controller can control the power of the air pump.

7. The transdermal drug delivery patch according to any one of claims 1-6, characterized in that, The unblocking unit includes at least one of micro needles, micro blades, and micro protrusions.

8. The transdermal drug delivery patch according to any one of claims 1-6, characterized in that, The transdermal drug delivery patch also includes an adhesive structure disposed on the drive device, and the adhesive structure is capable of fixing the transdermal drug delivery patch to the skin.

9. The transdermal drug delivery patch according to any one of claims 1-6, characterized in that, The transdermal drug delivery patch further includes a limiting portion, the surface of which in contact with the skin forms a limiting surface; the unblocking unit has an upper position and a lower position when repeatedly touching the skin, the upper position of the unblocking unit is higher than the limiting surface, and the lower position of the unblocking unit is not higher than the limiting surface.

10. A penetration-enhancing patch assembly, characterized in that, The penetration-enhancing patch assembly includes: A positioning patch, which can be fixed to the surface of the skin, has positioning holes; According to any one of claims 1-9, the transdermal drug delivery patch has a dredging device with a size not greater than the size of the positioning hole, and the dredging device is capable of repeatedly puncturing the skin exposed from the positioning hole.

11. The penetration-enhancing patch assembly according to claim 10, characterized in that, The positioning patch has an adhesive surface that can adhere to the skin and an assembly surface that can cooperate with the transdermal drug delivery patch. The assembly surface and the transdermal drug delivery patch are provided with a mating structure that can be disassembled and assembled.

12. The penetration-enhancing patch assembly according to claim 10, characterized in that, The enhanced penetration patch assembly also includes active ingredients that can be absorbed by the skin.

13. The penetration-enhancing patch assembly according to claim 12, characterized in that, The active ingredient is present in one of the following forms: gel patch, emulsion, or cream.

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