Substrate for patch with non-aqueous adhesive body

Abstract

To provide a base material capable of providing a patch in which a non-aqueous plaster is hard to bleed to the back side, and the sinking of the non-aqueous plaster is hard to occur.SOLUTION: An applicant of the present application finds the fact that, in a base material with a fiber sheet and the base material for a patch formed by applying a non-aqueous plaster, the patch with the non-aqueous plaster being hard to bleed to a back side can be provided by the thickness of the base material being thicker than 0.20 mm, and the patch where a non-aqueous plaster sinking portion is hard to occur can be provided when the air permeability of the base material is less than 154 cm3 / cm2 / sec. Accordingly, by the base material for satisfying a configuration concerning the present invention, the patch where the non-aqueous plaster is hard to bleed to the back side and the non-aqueous plaster sinking portion is hard to occur can be provided.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a substrate that can provide a patch in which a non-aqueous paste is less likely to bleed out to the backside and in which sinking of the non-aqueous paste is less likely to occur. [Background technology]

[0002] Patches (e.g., plasters) are used that are applied to the human body to, for example, exert anti-inflammatory and analgesic effects, exert cosmetic cosmetic effects, or impart a warming or cooling sensation. They are made by coating or impregnating a substrate comprising a fiber sheet with a paste containing an adhesive and medicinal ingredients. In particular, because plasters are used by being applied to the human body for extended periods of time, non-aqueous adhesives, such as rubber-based adhesives, that have strong adhesive strength are used as the adhesive contained in the paste. In this application, pastes containing non-aqueous adhesives are referred to as non-aqueous pastes.

[0003] Substrates that can be used for patches containing such aqueous or non-aqueous pastes are required to be resistant to the seepage of the paste to the back surface. Based on the knowledge that there is a proportional relationship between the air permeability and the ease of seeping out of the adhesive layer to the back side, the value calculated by dividing the air permeability of the substrate provided with the fiber sheet by the thickness of the substrate (air permeability per unit thickness) is smaller than 431; and - The thickness of the substrate provided with the fiber sheet is 0.48 mm or less, based on the knowledge that the substrate is thin and difficult to peel off; We proposed a substrate that satisfies both of these requirements. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent application 2019-110747 (claims, 0008-0012, etc.) Summary of the Invention [Problem to be solved by the invention]

[0005] In patches comprising such a base material, the aqueous or non-aqueous paste is indeed less likely to bleed through to the backside. However, when a patch comprising a non-aqueous paste is prepared and stored, partial sinking of the non-aqueous paste may occur on the main surface of the non-aqueous paste in the stored patch. In particular, when stored in a high-temperature environment, sinking of the non-aqueous paste is more likely to occur. Initially, it was thought that the sunken areas of the non-aqueous paste were caused by the non-aqueous paste seeping through to the back surface. However, just because a patch has sunken areas of the non-aqueous paste does not necessarily mean that the non-aqueous paste will seep through to the back surface. Therefore, in order to provide a patch that is less likely to have sunken areas of the non-aqueous paste, it was thought that it would be necessary to find a new configuration that could prevent the occurrence of sunken areas of the non-aqueous paste and to optimize that configuration.

[0006] In view of the above, the present invention aims to provide a substrate for a patch comprising a non-aqueous paste, which comprises a fiber sheet and is capable of providing a patch in which the non-aqueous paste is less likely to seep out to the back surface and in which areas where the non-aqueous paste is less likely to sink. [Means for solving the problem]

[0007] The first invention is " Hydroentangled nonwoven fabric containing crimped fibers It is equipped with Thickness is greater than 0.20mm and breathability is 61cm 3 / cm 2 / sec. or more 154cm 3 / cm 2 / sec. or less. Substrate for patch with non-aqueous adhesive body (However, this does not include hydroentangled nonwoven fabrics containing crimped fibers as constituent fibers, which are hydroentangled nonwoven fabrics obtained by heat treatment using water vapor to induce crimping of latent crimped fibers.) ." [Effects of the Invention]

[0008] The applicant of the present application has developed a substrate for a patch, which is a substrate having a fiber sheet and a non-aqueous paste applied thereto, comprising: The thickness of the base material is greater than 0.20 mm, so that a patch can be provided that is less susceptible to the non-aqueous paste seeping through to the back surface, and The air permeability of the substrate is 154 cm 3 / cm 2 / sec. or less, it is possible to provide a patch in which the non-aqueous paste is less likely to sink into a part, found. Therefore, by using a substrate that satisfies the above-mentioned configuration of the present invention, it is possible to provide a patch in which the non-aqueous paste is less likely to seep out to the back surface and in which sunken portions of the non-aqueous paste are less likely to occur. DETAILED DESCRIPTION OF THE INVENTION

[0009] In the present invention, various configurations can be appropriately selected, such as the following configurations. Note that, unless otherwise specified, the various measurements described in the present invention were performed under normal pressure and a temperature condition of 25°C. Furthermore, unless otherwise specified, the various measurement results described in the present invention were measured to a value one decimal place smaller than the desired value, and the value was calculated by rounding the value. As a specific example, when the desired value is measured to one decimal place, the value was measured to two decimal places, and the obtained value was rounded to one decimal place to calculate the value to one decimal place, and this value was used as the desired value. Furthermore, the upper and lower limits exemplified in the present invention can be combined in any combination.

[0010] The substrate for a patch comprising a non-aqueous adhesive base according to the present invention (hereinafter sometimes simply referred to as "substrate") comprises a fiber sheet. The fiber sheet referred to in the present invention refers to a sheet-like fiber assembly, such as a fiber web (e.g., a crosslay web, a parallel lay web, a crisscrosslay web, or a random web), a nonwoven fabric, or a woven or knitted fabric. Because the substrate of the present invention contains a fiber sheet, it is breathable, preventing stuffiness, and is flexible, allowing for excellent conformability to the human body, making it easy to provide a patch with an excellent application feel. Fiber sheets (particularly nonwoven fabrics), in which all constituent fibers are randomly entangled, are more flexible, and therefore a substrate comprising a nonwoven fabric is preferred. Furthermore, since the substrate comprises a fiber sheet, the entire surface has voids formed by the fibers surrounding each other. Portions of the nonaqueous paste enter these voids, providing anchoring properties, which facilitate the function of preventing the nonaqueous paste from remaining on the human body when the patch is removed.

[0011] The constituent fibers of the fiber sheet include, for example, polyolefin resins (e.g., polyethylene, polypropylene, polymethylpentene, polyolefin resins in which a portion of hydrocarbons is substituted with a nitrile group or a halogen such as fluorine or chlorine), styrene resins, polyvinyl alcohol resins, polyether resins (e.g., polyether ether ketone, polyacetal, modified polyphenylene ether, aromatic polyether ketone), polyester resins (e.g., polyethylene terephthalate, polytrimethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polybutylene naphthalate, polycarbonate, polyarylate, wholly aromatic polyester resin), polyimide resins, and the like. It can be constructed using known resins such as polyamideimide resin, polyamide-based resin (e.g., aromatic polyamide resin, aromatic polyetheramide resin, nylon resin, etc.), resin having a nitrile group (e.g., polyacrylonitrile, etc.), urethane-based resin, epoxy-based resin, polysulfone-based resin (e.g., polysulfone, polyethersulfone, etc.), fluorine-based resin (e.g., polytetrafluoroethylene, polyvinylidene fluoride, etc.), cellulose-based resin, polybenzimidazole resin, acrylic-based resin (e.g., polyacrylonitrile-based resin copolymerized with acrylic acid ester or methacrylic acid ester, modacrylic-based resin copolymerized with acrylonitrile and vinyl chloride or vinylidene chloride, etc.).

[0012] To prevent the medicinal ingredients and non-aqueous adhesive contained in the non-aqueous plaster from being absorbed by the constituent fibers of the fiber sheet, the constituent fibers of the fiber sheet preferably contain a polyolefin resin or a polyester resin, and more preferably the constituent fibers of the fiber sheet are composed solely of a polyolefin resin or a polyester resin.

[0013] These resins may be either linear or branched polymers, may be block or random copolymers, may have any three-dimensional structure, may have any crystallinity, or may be a mixture of multiple resin components.

[0014] In addition to the resins described above, the constituent fibers may contain additives such as flame retardants, fragrances, pigments, antibacterial agents, antifungal materials, photocatalytic particles, emulsifiers, dispersants, surfactants, thickeners, etc. The constituent fibers may be dyed fibers containing pigments.

[0015] The constituent fibers can be obtained by known methods, such as melt spinning, dry spinning, wet spinning, direct spinning (melt-blowing, spunbonding, electrostatic spinning, etc.), a method of extracting fibers with a small fiber diameter by removing one or more resin components from composite fibers, or a method of beating fibers to obtain split fibers.

[0016] The constituent fibers may be composed of one type of resin or multiple types of resins. Fibers composed of multiple types of resins may be generally called composite fibers, such as core-sheath type, sea-island type, side-by-side type, orange type, bimetal type, etc.

[0017] The constituent fibers may also include irregular cross-section fibers other than the generally circular and elliptical fibers. The irregular cross-section fibers may have a cross section that is hollow, polygonal such as triangular, alphabetic such as Y-shaped, irregular, multi-lobed, symbolic such as asterisk, or a combination of these shapes.

[0018] It is preferable that the fiber sheet contains elastic fibers as its constituent fibers, because the fibers are more flexible and have excellent elasticity, and therefore have excellent conformability to the human body, making it easier to provide a patch that provides an excellent application feeling. Examples of such elastic fibers include fibers containing an elastomer that is highly extensible, and crimped fibers in which the latent crimp of latent crimped fibers has been expressed.

[0019] Furthermore, the elastic fiber preferably does not contain an elastomer so that the medicinal ingredients and non-aqueous adhesive contained in the non-aqueous plaster base are less likely to be absorbed. From this perspective, it is preferable to use elastic fibers obtained by expressing the crimp of latent crimp fibers composed only of polyolefin resin or polyester resin.

[0020] When the fiber sheet contains heat-fusible fibers as constituent fibers, the fibers are heat-fused together to impart strength and dimensional stability to the substrate. Such heat-fusible fibers may be fully fusible heat-fusible fibers or partially fusible heat-fusible fibers such as the composite fibers described above. The component (resin) that exhibits heat-fusible properties in the heat-fusible fibers can be appropriately selected and used, such as heat-fusible fibers containing low-melting-point polyolefin resins or low-melting-point polyester resins.

[0021] When the fiber sheet is a fiber web or nonwoven fabric, it can be prepared by, for example, a dry method in which the above-mentioned fibers are fed into a carding device or an air-laying device to entangle the fibers; a wet method in which the fibers are dispersed in a solvent and then laid into a sheet to entangle the fibers; or a method in which fibers are spun using a direct spinning method (such as a melt-blowing method, a spunbonding method, an electrospinning method, or a method in which a spinning solution and a gas stream are discharged in parallel to spin the fibers (e.g., the method disclosed in JP-A-2009-287138)) and the fibers are collected.

[0022] The constituent fibers of the prepared fiber web can be entangled and / or integrated to prepare a nonwoven fabric. Examples of methods for entangling and / or integrating the constituent fibers include entanglement using needles or a water jet, and heat treatment of the fiber web to bond or fuse the constituent fibers together using a binder or adhesive fiber.

[0023] Even for patches that include a non-aqueous adhesive base with strong adhesive strength, it is preferable to use a hydroentangled nonwoven fabric as the substrate, so as to provide a patch that is less likely to undergo interlayer delamination when removed from the human body.

[0024] The heat treatment method can be appropriately selected, and examples thereof include a method of heating or heating and pressurizing with a roll, a method of heating by subjecting to a heater such as an oven dryer, a far-infrared heater, a dry heat dryer, or a hot air dryer, and a method of irradiating infrared rays without pressure to heat the resin contained therein.

[0025] A binder may be used to bond the fibers that make up the fiber sheet. Usable binders are appropriately selected, but examples include polyolefins (such as modified polyolefins), ethylene-vinyl alcohol copolymers, ethylene-acrylate copolymers such as ethylene-ethyl acrylate copolymers, various rubbers and their derivatives (such as styrene-butadiene rubber (SBR), fluororubbers, urethane rubbers, and ethylene-propylene-diene rubber (EPDM)), cellulose derivatives (such as carboxymethyl cellulose (CMC), hydroxyethyl cellulose, and hydroxypropyl cellulose), polyvinyl alcohol (PVA), polyvinyl butyral (PVB), polyvinylpyrrolidone (PVP), epoxy resins, polyvinylidene fluoride (PVdF), vinylidene fluoride-hexafluoropropylene copolymers (PVdF-HFP), acrylic resins (such as acrylic ester resins and acrylonitrile-styrene copolymer resins), and polyurethane resins.

[0026] In addition to the resins described above, the binder may contain additives such as flame retardants, fragrances, pigments, antibacterial agents, antifungal materials, photocatalytic particles, emulsifiers, dispersants, surfactants, and thickeners. However, since a substrate with excellent elasticity can provide a patch with excellent flexibility and elasticity, which allows it to conform to the human body and provides an excellent application feel, it is preferable that the fiber sheet constituting the substrate is not bonded to the fibers by heat-fusible fibers or a binder. As a method for providing such a preferred substrate, for example, a substrate having a fiber sheet formed by simply entangling the constituent fibers with a needle or a water flow is preferred.

[0027] When the fiber sheet is a woven or knitted fabric, the woven or knitted fabric can be prepared by weaving or knitting the fibers prepared as described above. In addition to the fiber web, a fiber sheet such as a nonwoven fabric or a woven or knitted fabric may also be subjected to the above-described method of entangling and / or integrating the constituent fibers.

[0028] The fineness and fiber length of the constituent fibers of the fiber sheet are not particularly limited. However, to provide a patch with excellent application comfort, such as excellent conformability to the human body due to excellent flexibility and stretchability, the fineness is preferably 0.6 to 6.6 dtex, more preferably 0.9 to 5.5 dtex, and even more preferably 1.2 to 4.4 dtex. Furthermore, the fiber length is preferably 20 mm or more, more preferably 25 mm or more, and even more preferably 30 mm or more. On the other hand, if the fiber length exceeds 110 mm, fiber clumps tend to form during preparation of the fiber sheet, which may make it difficult to provide a patch with excellent application comfort. Therefore, the fiber length is preferably 110 mm or less, more preferably 60 mm or less. The above-mentioned lower and upper limits can be arbitrarily combined as desired. The "fiber length" refers to a value measured in accordance with JIS L1015 (2010), 8.4.1c) direct method (method C).

[0029] The substrate may contain other materials in addition to the above-mentioned fiber sheet (for example, fabric, porous film, or breathable foam). However, it is preferable that the substrate be composed of only a fiber sheet, as this makes it easier to provide a patch that is comfortable to wear, as it has excellent properties such as preventing stuffiness and conforming to the human body, as described above.

[0030] The substrate according to the present invention has a thickness of more than 0.20 mm so as to provide a patch in which the non-aqueous paste is less likely to seep out to the backside. In other words, the thicker the substrate is, the more likely it is that a patch in which the non-aqueous paste is less likely to seep out to the backside can be provided. Therefore, the thickness of the substrate is preferably 0.25 mm or more, more preferably 0.30 mm or more, and more preferably 0.33 mm or more. There is no particular upper limit to the thickness of the substrate, but a thickness of 5 mm or less is practical, as this facilitates the provision of a patch that is excellent in terms of conformability to the human body when applied and provides an excellent feeling of application. In the present invention, "thickness" refers to the thickness of an area of ​​5 cm2 in the thickness direction relative to the main surface of the substrate. 2 The thickness in the load area is measured at five randomly selected locations with a load of 0.98 N (=100 gf) per unit area, and the arithmetic mean value of the thicknesses is calculated. Such thickness measurements can be performed using, for example, a high-precision digital length measuring instrument (Litematic (registered trademark), manufactured by Mitutoyo Corporation).

[0031] In addition, the base material of the present invention has an air permeability of 154 cm 3 / cm 2 / sec. is less than.

[0032] As a result of investigations, the applicant of the present application has found that the problem of partial sinking of the non-aqueous paste onto the main surface of the non-aqueous paste when a patch comprising a non-aqueous paste is stored (a problem that is particularly likely to occur when a patch comprising a non-aqueous paste is stored in a high temperature environment) occurs when the non-aqueous adhesive, such as a rubber-based adhesive contained in the non-aqueous paste, softens, increasing the fluidity of the non-aqueous paste, causing it to unintentionally flow from the surface of the substrate toward the interior of the substrate.

[0033] Furthermore, as a result of the investigation, the applicant of the present application has found that by adjusting the air permeability of the substrate, specifically, the air permeability of the substrate can be increased to 154 cm 3 / cm 2 / sec., it has been found that the non-aqueous paste having increased fluidity can be prevented from unintentionally flowing from the surface of the substrate into the interior of the substrate.

[0034] In other words, the air permeability of the substrate is 154 cm 3 / cm 2 / sec., the lower the air permeability, the more the non-aqueous adhesive, such as a rubber adhesive, contained in the non-aqueous adhesive can be prevented from unintentionally flowing from the surface of the substrate into the interior of the substrate, even if the non-aqueous adhesive has softened. 3 / cm 2 / sec. or less, and 130 cm 3 / cm 2 / sec. or less, and 100cm 3 / cm 2 / sec. or less is preferable, and 95cm 3 / cm 2 The lower limit of the breathability of the substrate is not particularly limited, but it is preferable that the breathability of the substrate is 0 cm / sec or less in order to easily provide a patch that is excellent in preventing stuffiness and conforming to the human body, and thus provides an excellent feeling of application. 3 / cm 2 / sec. Higher than 10cm is realistic. 3 / cm 2 / sec. or more is preferable.

[0035] In the present invention, the "air permeability" refers to the air permeability (unit: cm 3 / cm 2 sec.) is measured in accordance with JIS L1096:2010, 8.26.1 A method (Fragile method). In other words, the measurement area is 38 cm 2 Under these conditions, the air flow rate is adjusted so that the pressure is 125 Pa, and the unit time and the air permeability per unit time are measured. Such measurements of air permeability can be carried out using, for example, a Frazier-type air permeability tester (product number: FX3300) manufactured by TEXTESTAG. The unit of thickness of the substrate is "mm."

[0036] Other than the thickness and breathability of the substrate, other configurations of the substrate, such as basis weight, are not particularly limited and are adjusted as appropriate. The basis weight of the substrate is, for example, 10 to 200 g / m 2 and 20 to 180 g / m 2 and 30 to 160 g / m 2 In the present invention, the basis weight (unit: g / m 2 ) is calculated by measuring the mass and the area of ​​one of the main surfaces of one or more test pieces taken from the substrate, and calculating the mass of 1 m of the test piece from the total mass and the total area of ​​one of the main surfaces of the test piece. 2 This can be determined by calculating the mass per unit area.

[0037] The substrate of the present invention preferably has a breaking strength of 10 N / 50 mm width or more in both the longitudinal and transverse directions, more preferably 15 N / 50 mm width or more, and even more preferably 20 N / 50 mm width or more, so as to prevent breakage when the patch is misapplied or removed after use. The upper limit of the breaking strength is not particularly limited, but in practice it is 300 N / 50 mm width or less. This "breaking strength" is measured by taking a rectangular specimen 50 mm wide and 250 mm long from the substrate, pulling the specimen in the long direction using a constant-speed extension tensile tester (Tensilon, manufactured by Orientec Co., Ltd.), and measuring the maximum load applied until the specimen breaks. This maximum load is measured for three specimens, and the arithmetic average of these maximum loads is used as the "breaking strength." The measurement is performed under conditions of a grip distance of 200 mm and a pulling speed of 500 mm / min. In the present invention, the "longitudinal direction" refers to the production direction (flow direction) during production of the substrate, and the "lateral direction" refers to the direction perpendicular to the longitudinal direction, that is, the width direction.

[0038] Since the substrate of the present invention has better adhesion to the skin or other target object when it is more stretchable, the elongation percentage in both the longitudinal and transverse directions is preferably 15% or more, more preferably 20% or more, and even more preferably 25% or more. The upper limit of the elongation percentage is not particularly limited, but in practice it is 300% or less.

[0039] This elongation (Sr, unit: %) refers to the percentage of the elongation of the sample piece at the maximum load (Smax, unit: mm) [= (length at the maximum load, unit: mm) - (grip spacing = 200 mm)] relative to the grip spacing (200 mm) when the breaking strength was measured as described above. In other words, it is a value obtained from the following formula. This measurement was carried out three times, and the arithmetic mean value of the percentages is defined as the elongation in the present invention. Sr = (Smax / 200) × 100

[0040] To ensure that the substrate of the present invention is highly extensible and adheres well to skin and other targets, the tensile strength at 50% elongation in both the longitudinal and transverse directions is preferably 20 N / 50 mm width or less, more preferably 30 N / 50 mm width or less, and even more preferably 20 N / 50 mm width or less. The tensile strength at 50% elongation is practically 0.1 N / 50 mm width or more. The tensile strength at 50% elongation is measured by taking a sample piece 50 mm wide and 250 mm long from the substrate, fixing the sample piece with a gripping distance of 200 mm using a constant-rate extension tensile tester (Tensilon, manufactured by Orientec Co., Ltd.), and measuring the load at 100 mm (=50%) elongation (grip distance: 300 mm). This load measurement is performed on three sample pieces, and the arithmetic average of these loads is defined as the "tensile strength at 50% elongation." The measurement is carried out at a tension speed of 500 mm / min.

[0041] The substrate of the present invention preferably has a peel strength of 8.0 N / 50 mm width or more, preferably 10.0 N / 50 mm width or more, and preferably 15.0 N / 50 mm width or more, so that a patch that is less likely to delaminate when peeled from the human body can be provided, even for a patch comprising a non-aqueous adhesive base with strong adhesive strength. The peel strength can be determined by subjecting the substrate to the following measurement method.

[0042] (Method for measuring peel strength) (1) Prepare an adhesive tape (for example, Sekisui Chemical Co., Ltd., product name: Vinyl Cloth Tape No. 750, long side: 220 mm, short side: 50 mm) and overlap the adhesive tape over a range of 35 mm from one long side end to the other long side end, with the adhesive surface interposed between them, to form a gripping portion, and prepare a measurement adhesive tape (long side: 185 mm, short side: 50 mm). The exposed adhesive surface of the measurement adhesive tape has a long side of 150 mm and a short side of 50 mm, and the gripping portion has a length of 35 mm in the long side direction and a length of 50 mm in the short side direction. (2) In the same manner, prepare six pieces of adhesive tape for measurement. (3) Three test pieces (long side: 150 mm, short side: 50 mm) are taken from the substrate, and the entire exposed adhesive surface of the measurement adhesive tape is attached to each of both main surfaces of each test piece. At this time, the test pieces are attached to the substrate so that the gripping portions of both measurement adhesive tapes attached to the test piece are the shortest distance from each other. In this way, a total of three laminates are prepared, each consisting of measurement adhesive tape-measurement object-measurement adhesive tape in this order. (4) The laminate is placed in a mangle machine (processing speed: 2.0 m / min., pressure: 2.0 kgf, number of processing times: 1), and pressure is applied between both main surfaces of the laminate. (5) Fix each grip of both measuring adhesive tapes that make up the laminate to a fast-extension tensile tester (Tensilon, manufactured by Orientec Co., Ltd., distance between chucks at the start of measurement: 50 mm). Then, peel off the measuring adhesive tapes from the laminate until the total length between the chucks is 200 mm. (6) Calculate the average strength values ​​of the strength values ​​measured when the length between the chucks described in item 5 is a total of 100 mm, a total of 120 mm, a total of 140 mm, and a total of 160 mm. (7) The three prepared laminates are subjected to the above measurements, and the average of the obtained strength values ​​is calculated. The average value thus calculated is the peel strength (unit: N / 50 mm width) to be measured.

[0043] The substrate of the present invention may be printed with information such as the source, medicinal components, design, etc. Furthermore, the substrate of the present invention may be colored with a pigment or dye.

[0044] The substrate alone can be used as a substrate for a patch containing a non-aqueous adhesive base, but a laminated substrate may also be formed by laminating a cover material, a support, etc. Known cover materials and supports can be used, such as fabrics, porous films, and breathable foams. The laminated substrate may be formed by simply laminating these materials, or may be formed by interlayer bonding using a binder, hot melt web, or fiber adhesive, followed by an adhesive treatment such as heat sealing or ultrasonic welding.

[0045] The outer shape of the substrate can be adjusted appropriately and is not particularly limited, but can be, for example, a rectangular shape with rounded corners, a circle, or an oval shape, in addition to the shape of a raw sheet having a continuous length in the production direction and wound on a roll. The substrate may also have cutouts, punched-out parts, or notches.

[0046] A patch can be prepared by applying a non-aqueous paste to at least one main surface of the substrate of the present invention. The non-aqueous paste may be present on only one main surface of the substrate, or may be present on one main surface of the substrate and penetrate inward from that main surface.

[0047] The non-aqueous adhesive base of the present invention refers to an adhesive base containing a non-aqueous adhesive as the adhesive. While the constituent materials are not particularly limited, those having adhesive strength sufficient to fix the drug to the skin surface for a long period of time at room temperature are preferred. Examples of non-aqueous adhesives include rubber-based adhesives, acrylic-based adhesives, and silicone-based adhesives. Among these, rubber-based adhesives are preferred from the viewpoint of good adhesive properties and drug release, and natural rubber, synthetic isoprene rubber, polyisobutylene, polyvinyl ether, polyurethane, polyisoprene, polybutadiene, styrene-butadiene copolymer, styrene-isoprene copolymer, styrene-isoprene-styrene block (SIS) copolymer, and the like are particularly preferred. These may be used alone or in combination.

[0048] The non-aqueous adhesive can contain a medicinal ingredient. The type of ingredient is not particularly limited, as it is appropriately selected depending on the intended use of the patch, but for example, for patches intended for treatment, functional ingredients can be antipyretic analgesics, anti-inflammatory agents, cardiac stimulants, vitamins, cardiac medications (vasodilators), bronchodilators, local anesthetics, antipruritics, suppurative disease medications, hormones, etc.; for patches intended for cosmetic effects, functional ingredients that have a mild effect on the human body and are defined as quasi-drugs or cosmetics, such as cosmetic ingredients; for patches intended for a warming effect, functional ingredients can be capsicum extract, benzyl nicotinate, etc.; for patches intended for a cooling effect, functional ingredients can be hydrogels, cooling agents such as menthol, etc. [Example]

[0049] Examples of the present invention will be described below, but the present invention is not limited to the following examples.

[0050] (Comparative Example 1) A 100% by mass of latent crimped fiber A (fineness: 2.2 dtex, fiber length: 51 mm, cross-sectional shape: circular) composed only of polyester resin was fed to a carding machine to open the fibers, and the prepared fiber web was then fed to a hydroentanglement device, where water was applied to both main surfaces of the fiber web to entangle the constituent fibers. Next, the hydroentangled fiber web was subjected to a hot air dryer to develop the latent crimp of the constituent fibers, forming a nonwoven fabric composed only of crimped fibers. The thickness of this nonwoven fabric was then adjusted by passing it through nip rolls, and the base material (basis weight: 81.4 g / m) was obtained. 2 ) was manufactured.

[0051] Example 1 A substrate (basis weight: 89.0 g / m) was prepared in the same manner as in Comparative Example 1, except that latent crimped fiber B (fineness: 1.3 dtex, fiber length: 44 mm, cross-sectional shape: circular) composed only of polyester resin was used instead of latent crimped fiber A. 2 ) was manufactured.

[0052] (Example 2, Comparative Example 2) The nonwoven fabric of Comparative Example 1 was heat-pressed to have a predetermined thickness and breathability to produce two types of substrates.

[0053] (Example 3, Comparative Example 3) The nonwoven fabric of Example 1 was heat-pressed to have a predetermined thickness and breathability to produce two types of substrates.

[0054] In addition, the prepared substrates of the Examples and Comparative Examples were subjected to the following confirmation methods to evaluate the resistance to seeping and the presence or absence of sinking in the patches prepared using the substrates.

[0055] (How to check the resistance to bleeding) A non-aqueous paste containing the following composition was prepared. ·SIS copolymer: 1.0 part by mass Polyisobutylene: 6.0 parts by mass Hydrogenated rosin ester: 7.5 parts by weight Liquid paraffin: 10.0 parts by mass Toluene: 50.0 parts by mass A polyethylene terephthalate film having a silicone layer on one main surface was prepared, and the prepared non-aqueous paste was applied to the main surface on the silicone layer side, followed by drying at room temperature for 24 hours or more. A polyethylene terephthalate film was laminated on one main surface of the substrate with a non-aqueous paste in between to prepare a laminate. Three square samples, each 3 cm on a side, were then taken from the laminate. A 6 kg glass plate was placed on the main surface of the polyethylene terephthalate film side of the collected sample for 10 minutes, and a load (6 kg / 9 cm) was applied in the thickness direction of each sample. 2 ) was applied. Each sample that had been pretreated in this way was sealed in an aluminum pouch and subjected to an accelerated test for 5 days in a constant temperature and humidity chamber (temperature: 50°C, humidity: 30 RH%). After the accelerated test, the main surface of the sample on which the substrate was exposed (the main surface of the substrate opposite to the side on which the non-aqueous paste was applied) was visually inspected and evaluated according to the following criteria. ◯: In all samples, no non-aqueous paste was present on the main surface where the base material was exposed, and no bleeding occurred. ×: In one or more samples, a non-aqueous paste was present on the main surface where the substrate was exposed, and bleeding had occurred. Substrates rated as "○" in this confirmation method are substrates that can provide patches in which the non-aqueous paste is less likely to bleed to the backside, while substrates rated as "×" in this confirmation method are substrates in which it is difficult to provide patches in which the non-aqueous paste is less likely to bleed to the backside.

[0056] (How to check for sinking) After each sample was removed from the thermo-hygrostat prepared in the above-mentioned section (Method for confirming resistance to bleeding), the main surface of the non-aqueous plaster mass applied to the substrate was observed from the side where the polyethylene terephthalate film was present using a stereomicroscope at a magnification of 10. The observation results were evaluated according to the following criteria. ◯: There were no areas on the main surface of the non-aqueous paste where the non-aqueous paste had partially sunk. ×: Partially sunk portions of the non-aqueous paste were present on the main surface of the non-aqueous paste.

[0057] The structure and physical properties of the substrates prepared in each of the Examples and Comparative Examples are summarized in Table 1. Items that were not measured are marked with "-" in the table.

[0058] [Table 1]

[0059] When the base materials prepared in Comparative Examples 2 and 3 were used, patches in which the nonaqueous paste was less likely to bleed to the back surface could not be provided. In contrast, when the base materials prepared in Comparative Example 1 and Examples 1 to 3 were used, patches in which the nonaqueous paste was less likely to bleed to the back surface could be provided. This is thought to be because the base materials prepared in Comparative Examples 2 and 3 were thin, at 0.20 mm or less, and the nonaqueous paste bled to the back surface, whereas the base materials prepared in Comparative Example 1 and Examples 1 to 3 were thicker and therefore less likely to bleed to the back surface.

[0060] Furthermore, when the base material prepared in Comparative Example 1 was used, it was not possible to provide a patch in which the non-aqueous paste was less likely to sink into areas. In contrast, when the base materials prepared in Examples 1 to 3 and Comparative Examples 2 and 3 were used, it was possible to provide a patch in which the non-aqueous paste was less likely to sink into areas. The reason for this is that the base material prepared in Comparative Example 1 had an air permeability of 154 cm 3 / cm 2 / sec. or more, and the nonwoven fabric had a coarse, sparse structure, so it was not possible to provide a patch that was less likely to produce areas where the nonaqueous paste sank, whereas the base materials prepared in Examples 1 to 3 and Comparative Examples 2 and 3 had lower air permeability than this, and it was thought that this allowed the provision of a patch that had a dense, nonwoven fabric structure and was less likely to produce areas where the nonaqueous paste sank.

[0061] Although the substrates prepared in Example 1 and Comparative Example 1 both had a thickness of 0.55 mm, a patch in which areas where the non-aqueous paste sunk was unlikely to occur was provided when the substrate prepared in Example 1 was used, whereas a patch in which areas where the non-aqueous paste sunk was unlikely to occur was not provided when the substrate prepared in Comparative Example 1 was used. These results revealed that there is no direct correlation between the thickness of the substrate and whether or not the substrate is capable of realizing a patch in which areas where the non-aqueous paste sunk are unlikely to occur.

[0062] As described above, by using a substrate that satisfies the constitution of the present invention, it is possible to provide a patch in which the non-aqueous paste is less likely to seep out to the backside and in which the non-aqueous paste is less likely to sink into portions. [Industrial Applicability]

[0063] The base material for a patch comprising the nonaqueous adhesive mass of the present invention can be used to provide patches (e.g., poultices, plasters, tape preparations, surgical tapes, taping materials and bandages, facial masks, warming sheets and cooling sheets) that are intended to exert anti-inflammatory and analgesic effects, to exert cosmetic cosmetic effects, or to impart a warming or cooling sensation.

Claims

[Claim 1] A hydroentangled nonwoven fabric containing crimped fibers as constituent fibers, Thickness is greater than 0.20 mm and breathability is 61 cm ３ / cm ２ / sec. 154cm or more ３ / cm ２ / sec. is less than A substrate for a patch comprising a non-aqueous paste (excluding those comprising a hydroentangled nonwoven fabric containing crimped fibers as the constituent fibers and obtained by subjecting the latent crimped fibers to a heat treatment using water vapor).

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