Sample collection support equipment and sample collection device

Abstract

The present invention addresses the problem of obtaining a sample collection support instrument that makes it possible to use a syringe to stably and accurately collect a sample. A sample collection support instrument 100 according to the present invention is an instrument for assisting in using a syringe 1 to collect a sample, wherein the sample collection support instrument 100 comprises: a main body unit 100a that includes a grip part 100b; and a holder 110 that is attachable to the syringe 1 and that is for holding a piston rod 4, which is included in the syringe 1, in such a manner as to be movable forward and backward, and the main body unit 100a includes a vibration means 120 that vibrates the holder 110.

Description

[Technical Field]

[0001] The present invention relates to a sample collection support instrument that assists in collecting a sample using a syringe, and a sample collection device that combines a sample collection support instrument with a syringe needle. [Background technology]

[0002] Conventionally, there have been devices that assist in the collection of biological tissues and the like using a syringe. For example, Patent Document 1 discloses an auxiliary device that is attached to a syringe used for such purposes and generates negative pressure within the syringe. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Special Publication No. 2014-529305 Summary of the Invention [Problem to be solved by the invention]

[0004] However, in the syringe equipped with the auxiliary device described in Patent Document 1, it is not possible to stably and efficiently draw biological tissue into the syringe, and there is a risk of bleeding or nerve damage.

[0005] An object of the present invention is to provide a sample collection support instrument that enables stable and accurate collection of a sample using a syringe, and a sample collection device that combines the instrument with a syringe. [Means for solving the problem]

[0006] The present invention provides the following items.

[0007] (Item 1) A sample collection support device that assists in collecting a sample using a syringe, comprising: The sample collection support device includes: a main body portion including a grip portion; a holder that can be attached to the syringe and that holds a piston rod provided in the syringe so that the piston rod can move forward and backward; and The sample collection support device, wherein the main body portion is provided with vibration means for vibrating the holder.

[0008] (Item 2) the holder has a base member and a slide lever that can advance and retreat relative to the base member, The base member is a protrusion provided at a tip end thereof and insertable into a syringe provided in the injector; a connected portion provided at a base end portion and connected to the connecting portion of the main body portion; and Item 2. The sample collection support device according to item 1, wherein the slide lever has an engagement portion that can engage with the piston rod.

[0009] (Item 3) Item 3. The sample collection support device according to item 2, wherein the slide lever is configured to engage with the base member and lock movement in the forward direction when in a position where the slide lever is retracted by a predetermined amount.

[0010] (Item 4) the base member has an opening; Item 4. The sample collection support device according to item 3, wherein the slide lever is configured to engage with the opening when the slide lever is in a position where it is retracted by the predetermined amount, thereby locking the movement of the slide lever in the forward direction.

[0011] (Item 5) 5. The sample collection support device according to claim 4, wherein the engagement between the slide lever and the opening is achieved by the forward side surface of the opening abutting against the forward end of the slide lever.

[0012] (Item 6) Item 3. The sample collection support device according to item 2, wherein the slide lever has a first finger rest for resting a first finger and / or a second finger rest for resting a second finger.

[0013] (Item 7) 7. The sample collection support device according to item 6, wherein the first finger grip portion is included in the engagement portion.

[0014] (Item 8) Item 2. The sample collection support device according to item 1, wherein the vibration means has a rotary motor and a motion conversion mechanism that converts rotary motion generated by the rotary motor into linear motion.

[0015] (Item 9) Item 4. The sample collection support device according to item 3, wherein the base member has a finger rest portion for assisting in unlocking the lock and a slit at the tip.

[0016] (Item 10) Item 10. The sample collection support device according to item 9, wherein the base member further comprises a slit at the tip portion to assist in releasing the lock.

[0017] (Item 11) The sample collection support device according to claim 2 , wherein the base member is provided with a rib portion for hooking onto the syringe.

[0018] (Item 12) The motion conversion mechanism includes: an eccentric rotary pulley attached to a rotary shaft of the rotary motor; a connecting crank that connects the eccentric rotating pulley and the holder; Item 9. The sample collection support device according to item 8, comprising:

[0019] (Item 13) A sample collection support device according to any one of items 1 to 12, Syringe and A sample collection device comprising:

[0020] (Item 14) 14. The sample collection device of item 13, wherein the sample is a cell. [Effects of the Invention]

[0021] According to the present invention, it is possible to provide a sample collection support instrument that enables stable and accurate collection of a sample using a syringe, and a sample collection device that combines this with a syringe needle. [Brief explanation of the drawings]

[0022] [Figure 1] 1 is a diagram illustrating a sample collection support device 100 according to the present invention. [Figure 2] 2 is a diagram showing the external appearance and internal structure of a sample collection support device 100 according to a first embodiment of the present invention, which is a specific configuration of the sample collection support device 100 of the present invention shown in FIG. 1. FIG. [Figure 3] 3 is an exploded view showing the specific configuration of the holder 110 and the main part (motion conversion mechanism) of the vibration means 120 shown in FIG. 2. FIG. [Figure 3A] 3A and 3B are views showing another embodiment of the holder 110 shown in FIG. 2. [Figure 4] 3 is a diagram illustrating a mechanism by which a slide lever 110b for attracting a piston rod 4 of an injection needle 5 attached to the holder 110 shown in FIG. 2 is locked to a base member. FIG. [Figure 5] 3 is a diagram showing a state in which the syringe 10 is attached to the holder 110 shown in FIG. 2. FIG. [Figure 6] 3 is a diagram showing the positional relationship between the slide lever 110b and the base member 110a when the syringe 10 attached to the holder 110 shown in FIG. 2 is in a negative pressure state. FIG. DETAILED DESCRIPTION OF THE INVENTION

[0023] The present invention will be described below.Unless otherwise specified, it should be understood that the terms used in this specification are used in the meanings generally used in the relevant field.Therefore, unless otherwise defined, all technical terms and scientific terms used in this specification have the same meaning as those generally understood by those skilled in the art to which this invention belongs.In the event of any discrepancy, this specification (including definitions) shall prevail.

[0024] In this specification, the term "about" refers to a range of ±10% of the following number.

[0025] The present invention aims to provide a sample collection support device that enables stable and efficient collection of a sample using a syringe, A sample collection support device that assists in collecting a sample using a syringe, comprising: Sample collection support equipment includes: a main body portion including a grip portion; a holder that can be attached to the syringe and that holds a piston rod of the syringe so that the piston rod can move back and forth; and The above-mentioned problem is solved by providing a sample collection support device in which the main body is provided with vibration means for vibrating the holder.

[0026] Therefore, as long as the sample collection support device of the present invention has a holder capable of holding a syringe so that a negative pressure is created inside the syringe, and further has a function of vibrating this holder (vibration means), other configurations are not particularly limited.

[0027] For example, the holder is attachable to a syringe and has a configuration for holding the piston rod of the syringe in a manner that allows it to move back and forth, but other configurations are not particularly limited. For example, the holder may have a base member and a slide lever that can move back and forth relative to the base member.

[0028] The holder may be attached to the syringe in any manner, preferably in a detachable manner, which allows multiple samples to be collected using a single sample collection support device by simply replacing the syringe, thereby achieving low costs. In the sample collection support device of the present invention, the sample to be collected may be any sample. For example, it may be cells or tissues from a living organism (human body, animal, plant, etc.), or a fluid such as blood. It may also be a substance (e.g., a fluid) present inside an artificial body, not limited to a living organism. In a particularly preferred embodiment, it is used to collect cells from within a living organism (so-called "fine needle aspiration cytology (FNAC)").

[0029] In one embodiment, the mounting configuration is a projection of a base member of the holder, which will be described in detail below, and an engagement portion that engages with the piston rod of the slide lever, but the present invention is not limited to this. The holder portion may also be configured to clamp a part of the syringe of the injector.

[0030] In this case, in one embodiment, the holder has a base member having a protrusion that can be inserted into a syringe provided in the injector, the protrusion being provided at the tip of the base member, and the slide lever has an engagement portion that can engage with the piston rod.

[0031] In this case, it is preferable that the slide lever is configured to be locked against forward movement by engaging with the base member at a position where it is retracted a predetermined amount, because when the slide lever is locked at a position where it is retracted to a predetermined position relative to the base member, movement of the slide lever from the retracted position is restricted (i.e., movement in the forward direction is disabled), making it possible to maintain the negative pressure state generated within the syringe. The materials for the slide lever and base member can be any material. For example, they can be metals such as stainless steel or aluminum, or resins such as plastic. Resin is preferable because it can be replaced inexpensively in the event of damage or wear. The slide lever and base member can also be made of different materials.

[0032] More specifically, it is preferable that the base member has an opening, and when the slide lever is retracted by the predetermined amount, the slide lever engages with the opening in the base member to lock the movement of the slide lever in the forward direction. This is because the movement of the slide lever is locked simply by engaging a part of the slide lever (the abutment piece) with the inner end of the opening in the base member, and the movement of the slide lever can be locked with a simple configuration. The engagement of the slide lever with the opening in the base member is easily achieved by abutting the forward side surface of the opening with the forward end of the slide lever.

[0033] The slide lever may have any form. For example, the slide lever may have at least one finger hook that can be used to hook a finger so that it can be operated by hand. The slide lever preferably has a first finger hook for hooking a first finger and / or a second finger hook for hooking a second finger. By having such a first finger hook and a second finger hook, the slide lever can be operated with one hand more stably and accurately than when there is only one first finger hook or one second finger hook. Note that the slide lever of the present invention may have a drive source and be driven automatically rather than by manual operation.

[0034] Furthermore, it is preferable that the first finger hook of the slide lever is included in the engagement portion that engages with the piston rod, which allows the force of the finger operating the slide lever to be efficiently transmitted to the piston rod.

[0035] For example, in one embodiment, the first finger rest is configured so that the middle finger or ring finger can be placed thereon, and the second finger rest is configured so that the index finger or middle finger can be placed thereon.

[0036] The connected portion that is connected to the connecting portion of the main body portion of the base member can be in any form as long as it can be connected to the main body portion. The connected portion may be fixed integrally with the connecting portion of the main body portion so as not to be detachable, or it may be configured to be detachable. Preferably, the connection between the non-connecting portion and the connecting portion of the main body portion is detachable. By making it detachable in this way, it becomes possible to replace only the holder portion that is prone to wear and damage, and it becomes possible to achieve low costs.

[0037] For example, the connection between the connecting portion and the connected portion may be an electromagnetic connection such as a magnet, a fitting structure between a recess and a protrusion, or a connection by adhesive means or the like.

[0038] Furthermore, the vibration means may be of any form as long as it is capable of vibrating the holder in the forward and backward directions. For example, it may be equipped with an ultrasonic vibration motor, or may be a reciprocating sliding mechanism. A preferred embodiment is configured to include a rotary motor and a motion conversion mechanism that converts the rotary motion of the rotary motor into linear motion. This configuration makes it possible to use a general-purpose rotary motor as the drive source. Here, it is preferable that the motion conversion mechanism specifically includes an eccentric rotary pulley attached to the rotary shaft of the rotary motor and a connecting crank that connects the eccentric rotary pulley to the holder.

[0039] This is because, in the motion conversion mechanism, by connecting one end of the connecting crank to the eccentric rotating pulley, the other end of the connecting crank can be made to move linearly, and as a result, motion conversion is possible with a simple configuration.

[0040] Such a sample collection support instrument can be combined with a syringe to realize a sample collection device for collecting a sample.

[0041] FIG. 1 is a diagram illustrating a sample collection support device of the present invention.

[0042] The sample collection support device 100 of the present invention is a device that supports collection of a sample from a subject using a syringe 1.

[0043] The sample collection support device 100 has a main body 100a equipped with a gripping portion 100b, and a holder 110 that can be attached to the syringe 1. The holder 110 holds the piston rod 4 of the syringe 1 so that it can move back and forth, and the main body 100a is equipped with vibration means 120 that vibrates the holder 110 to which it is connected. In one embodiment, the vibration means 120 is stored in a housing 101 that constitutes the main body 100a.

[0044] As described above, the sample collection support device of the present invention has a vibration means for vibrating the holder. By activating the vibration means while the slide lever is locked in the retracted position, the syringe barrel of the syringe can be stably and accurately vibrated, resulting in stable and accurate sample collection from the syringe barrel. Conventional techniques either do not vibrate the holder at all, or vibrate the holder manually. Manual vibration is unstable and inaccurate, making it difficult to stably and accurately collect samples. Manual vibration poses particular risks of bleeding and nerve damage, causing fear in patients. Sample collection using the sample collection support device of the present invention offers the excellent advantage of enabling stable and accurate sample collection without the risk of bleeding or nerve damage and regardless of the operator's skill.

[0045] The following describes the configuration of the sample collection support device 100 of embodiment 1, which embodies each part of the sample collection support device 100 of the present invention. Note that the same reference numerals are used to denote corresponding parts in the explanatory diagram of the present invention (FIG. 1) and the explanatory diagrams of embodiment 1 (FIGS. 2 to 6). Here, the sample collection support instrument 100 and the injection needle 1 constitute a sample collection device 1000 for acquiring a sample from a subject.

[0046] In the following embodiment, the holder 110 has a base member 110a and a slide lever 110b that can move forward and backward relative to the base member 110a, the base member 110a has a protrusion 112a that can be inserted into a syringe 2 provided in the injector 1, and a connected portion 114a that is connected to a connecting portion 113a of the main body portion 100a, the protrusion 112a is provided at the tip portion of the base member 110a, the connected portion 114a is provided at the base end portion of the base member 110a, and the slide lever 110b has an engaging portion (lower part of the lever) 10b that can engage with the piston rod 4 (see Figure 2).

[0047] In the configuration of the sample collection support device 100 of embodiment 1, the protrusion 112a of the base member 110a is inserted into the syringe 2, and the engagement portion 15b of the slide lever 110b engages with the piston rod 4, whereby the syringe 2 of the syringe 1 is fixed to the base member 110a, and the piston rod 4 of the syringe 1 can move relative to the base member 110a together with the slide lever 110b.

[0048] (Embodiment 1) The configuration of each part of the sample collection support device 100 according to the first embodiment of the present invention will be specifically described below.

[0049] 2A and 2B show a specific configuration of a sample collection support device 100 according to the first embodiment of the present invention, with FIG. 2A showing its external appearance and FIG. 2B showing the internal structure of the sample collection support device 100. As shown in FIG.

[0050] The sample collection support device 100 of the first embodiment is a device for collecting cells from living organisms such as humans, animals, and plants using a syringe 1. As shown in FIG. 2(a), it has a main body 100a equipped with a gripping portion 100b, and a holder 110 that can be attached to the syringe 1. The holder 110 is connected to the main body 100a and holds a piston rod 4 of the syringe 1 so that the piston rod 4 can move back and forth. The main body 100a is equipped with vibration means 120 that vibrates the holder 110, and this vibration means 120 is stored in a housing 101 that constitutes the main body 100a (see FIG. 2(b)).

[0051] Specific configurations of the main body 100a and the holder 110 will be described below with reference to FIGS.

[0052] 3A and 3B are exploded views showing the main parts of the holder 110 and the vibration means 120 shown in FIG. 2, with FIG. 3A showing the housing 101 of the main body 100a, the base member 110a, and the slide lever 110b separated, FIG. 3B showing the connection state between the base member 110a and the motion conversion mechanism 122, and FIG. 3C showing the motion conversion mechanism 122 exploded into the connecting crank 122a and the eccentric rotating pulley 122b.

[0053] (Main body 100a) The lower part of the surface of the housing 101 constituting the main body 100a is a gripping part 100b that the operator holds with one hand (e.g., the ring finger and little finger), as shown in Figures 2 and 5(a), and a vibration means 120 is housed within the housing 101.

[0054] Specifically, housing 101 houses rotary motor 121, which is a drive source, and battery 124, which is its power source. Also, on the tip side of the upper part of housing 101 (the side on which syringe 1 is attached), switch (vibration switch) 123 for rotary motor 121 is provided so as to be operable with the thumb when gripping portion 100b of housing 101 with, for example, the ring finger and little finger.

[0055] Also housed within housing 101 are a motion conversion mechanism 122 that converts the rotational motion of rotary motor 121 into linear motion, and a plate-shaped connecting portion 113a that is connected to connected portion 114a of base member 110a that constitutes holder 110. Specifically, motion conversion mechanism 122 includes eccentric rotating pulley 122b that is attached to the rotation shaft of motor 121, and connecting crank 122a that is connected thereto.

[0056] A connecting shaft 22a is formed at one end of the connecting crank 122a, and a pulley connecting hole 22b is formed at the other end of the connecting crank 122a. The eccentric rotating pulley 122b has a rotation shaft 22c that rotates on its own axis and a revolution shaft 22d that revolves around the axis of the rotation shaft 22c, and the revolution shaft 22d is attached to the upper surface of the rotation shaft 22c.

[0057] The connecting shaft portion 22a formed at one end of the connecting crank 122a is rotatably connected to the crank connecting hole 13a of the connecting portion 113a for connecting to the connected portion 114a of the base member 110a of the main body portion 100a, and the pulley connecting hole 22b formed at the other end of the connecting crank 122a is rotatably attached to the orbital shaft portion 22d of the eccentric rotating pulley 122b.

[0058] The housing 101 constituting the main body 100a has a structure that can be disassembled into a container side portion with an open side that houses the motor 121 etc., and a lid portion that closes the opening on the side of the container side portion, and the container side portion is formed with a screw threading portion 102 into which a screw that fixes the lid side portion to the container side portion is screwed. The connecting portion 114a is basically fixed to the main body 100a in an undetachable state. The shape and material of the connecting portion can be arbitrary. For example, in one embodiment, The connecting portion may be made detachable from the main body 100a and made of resin, so that it can be replaced at low cost.

[0059] (Holder 110) As shown in FIG. 3(a), the holder 110 has a base member 110a to which the syringe 2 of the injector 1 is attached, and a slide lever 110b attached to the base member 110a so as to be movable forward and backward.

[0060] (base member 110a) 3(a), the base member 110a includes a lever mounting portion (base main body) 111a to which the slide lever 110b is mounted, a protrusion 112a provided at the tip end of the base main body 111a, and a connected portion 114a provided at the base end of the base main body 111a, and one end of a connecting crank 122a that constitutes the motion converting mechanism 122 is rotatably connected to the connected portion 114a via the connecting portion 114a of the main body 100a. An opening 11a is formed in the base main body 111a, and an opening (guide opening) 12a that is narrower than the opening 11a and connects to the opening 11a is formed between the opening 11a and the protrusion 112a, and a guide protrusion 11b of the slide lever 110b (see FIG. 4) slides within the guide opening 12a (see FIG. 4). The slide lever 110b passes through this opening 11a, and the slide lever 110b engages with this opening 11a at a position where it is retracted a predetermined distance (a predetermined amount) together with the piston rod 4, thereby locking the slide lever 110b to the base member 110a, so that the syringe 2 will not return to its original position even if the operator releases the slide lever 110b in a state where negative pressure is generated inside the syringe 2 of the injector 1. Here, the engagement between the slide lever 110b and the opening 11a is achieved by the forward-side side surface of the opening 11a coming into contact with the forward-side end portion of the slide lever 110b.

[0061] (Slide lever 110b) As shown in Figures 2 and 3(a), the slide lever 110b has a lower lever part 10b located below the upper surface of the base member 110a and an upper lever part 20b located above the upper surface of the base member 110a. The lower lever part 10b is an engagement part that engages with the piston rod 4 and includes a first finger hook part for hooking a first finger (e.g., middle finger) F3, and the upper lever part 20b is a second finger hook part for hooking a second finger (e.g., index finger) F2 (see Figure 5(b)). It is also possible to hook the ring finger F4 on the first finger hook part and the middle finger F3 on the second finger hook part.

[0062] The lever lower portion 10b has a pair of left and right side walls 112b, reinforcing ribs 113b that reinforce these side walls, a guide portion 114b that is provided along the upper edge of the side walls 112b and moves along the side surface of the base body 111a, and a connecting wall 115b that connects the both side walls 112b. A rod mounting groove 15b into which the base end of the piston rod 4 is attached is formed in this connecting wall 115b.

[0063] The lever upper part 20b has a sliding plate 117b that slides on the base member 110a and a protruding piece 116b formed to protrude from the upper surface of the sliding plate 117b. The center of the tip of the sliding plate 117b forms a contact piece 111b (the forward end of the slide lever 110b) that can come into contact with the inner edge (the forward side surface) of the opening 11a formed in the base member 110a, and sliding pieces 118b that slide on the surface of the sliding plate 117b are provided on both sides of the contact piece 111b (see FIG. 4). Note that the detailed structure of the lever upper part 20b, in which the sliding pieces 118b are provided on both sides of the contact piece 111b, is shown only in FIG. 4.

[0064] FIG. 3A shows another embodiment of the holder 110 shown in FIG. 3. The holder 110x of the embodiment shown in FIG. 3A differs from the holder 110 shown in FIG. 3 in that it has a rib 115a on the base member 110a for hooking onto the flange of the syringe 2, a pair of finger rests 116a on the top surface of the connected portion 114b of the slide lever 110a to enable easy one-handed release of the lock, and a slit 117a extending in the vertical direction on the protrusion 112a at the tip of the holder 110. Since the other components are the same, reference numerals and the like are omitted. Next, the mechanism by which the slide lever 110b is locked to the base member 110a will be described.

[0065] 4A and 4B are diagrams for explaining the mechanism by which the slide lever 110b is locked to the base member 110a in the holder 110 shown in FIG. 2, with FIGS. 4A and 4B showing the unlocked state, FIGS. 4C and 4D showing the locked state, FIG. 4B being a cross-sectional view taken along line AA in FIG. 4A, and FIG. 4D being a cross-sectional view taken along line BB in FIG. 4C.

[0066] In the unlocked state shown in Figures 4(a) and (b), the abutment piece 111b, which is part of the sliding plate 117b of the slide lever 110b, is located on the surface of the base body 111a around the opening 11a of the base member 110a, and the slide lever 110b is movable in the front-to-back direction on the base member 110a (left-to-right direction on the paper surface of Figure 4) along the side edge of the base body 111a by the guide part 114b and the guide protrusion 11b.

[0067] In contrast, in the locked state shown in Figures 4(c) and (d), the slide lever 110b is further to the right of the base member 110a (in other words, the piston rod 4 is further retracted) compared to the state shown in Figures 4(a) and (b). In other words, when the slide lever 110b is retracted a predetermined amount, the abutment piece 111b is in a state of dropping into the opening 11a of the base member 110a. In this state, the inside of the syringe 2 is in a negative pressure state, and the piston rod 4 is forced toward the injection needle 5 side. At this time, the abutment piece 111b is in a state of having fallen into the opening 11a of the base member 110a. Therefore, when the piston rod 4 tries to return to the side of the injection needle 1, the abutment piece 111b of the slide lever 110b (i.e., the forward end of the slide lever 110b) abuts against the inner edge (forward side surface) of the opening 11a of the base member 110a, and the slide lever 110b maintains the piston rod 4 in a state where negative pressure is generated inside the syringe 2.

[0068] Next, a method of operating the sample collection support device 100 of this embodiment will be described.

[0069] Figure 5 shows the state in which the syringe 1 is attached to the holder 110 of the sample collection support device 100 shown in Figure 2, where Figure 5(a) shows the appearance of the injection needle 1 and the sample collection support device 100, and Figure 5(b) shows the internal structure of the sample collection support device 100. Note that Figure 5(b) shows the piston rod 4 of Figure 5(a) in more detail.

[0070] First, as shown in Figures 5(a) and 5(b), protrusion 112a at the tip of holder 110 is hooked onto the edge of the base end of syringe 2 of syringe 1, and the base end portion of piston rod 4 of syringe 1 is fitted into rod mounting groove 15b of connecting wall 115b of slide lever 110b, thereby fixing syringe 1 to holder 110. At this time, if there is rib 115a shown in Figure 3A, by hooking this rib 115a onto the flange portion of syringe 1 (syringe 2), holder 110 can be firmly fixed to the syringe, allowing for more stable operations such as puncturing.

[0071] Thereafter, the user holds the main body 100a in one hand (here, the right hand) by wrapping the palm around the housing 101 of the sample collection support device 100 and hooking, for example, the ring finger F4 and little finger F5 around the gripping portion 100b (see Figure 5(b)).

[0072] Then, the user places, for example, the middle finger F3 of the same hand on the lower lever 10b of the slide lever 110b, and the index finger F2 of the same hand on the upper lever 20b of the slide lever 110b. In this state, the injection needle 5 is inserted into a part of the object (for example, a human body). The middle finger F3 and index finger F2 then pull the slide lever 110b toward the main body 100a of the sample collection support device 100. This causes the slide lever 110b to move toward the base end of the base member 110a (to the right in FIG. 5(b)) relative to the base member 110a. At this time, since the syringe 2 of the injector 1 is fixed to the base member 110a, the piston rod 4, which moves together with the slide lever 110b relative to the base member 110a, moves in the direction of being pulled out relative to the syringe 2 (to the right in FIG. 5(b)). As a result, a negative pressure is created inside the syringe 2.

[0073] 6A and 6B are diagrams showing a state in which the holder 110 of the sample collection support device 100 shown in Fig. 2 maintains a negative pressure state for the syringe 10, with Fig. 6A showing the appearance of the syringe 1 and the sample collection support device 100 and Fig. 6B showing the internal structure of the sample collection support device 100. Note that Fig. 6B shows the piston rod 4 of Fig. 6A more specifically.

[0074] Then, when the slide lever 110b moves together with the piston rod 4 relative to the base member 110a and the abutment piece 111b of the slide lever 110b reaches the edge of the opening 11a of the base member 110a (a position where the slide lever 110b has retracted a predetermined amount), the abutment piece 111b (FIGS. 4(a) and 4(b)), which had been sliding on the surface (top surface) of the base member 110a, falls into the opening 11a (FIGS. 4(c) and 4(d)). This causes the slide lever 110b to enter a locked state (engaged state) in which its movement in the forward direction relative to the base member 110a is locked. Specifically, this locked state is achieved by the engagement between the slide lever 110b and the opening 11a of the base member 110a, and this engagement is achieved by the abutment between the forward side surface of the opening 11a of the base member 110a and the forward end portion of the slide lever 110b (the tip of the abutment piece 111b).

[0075] In this locked state, when the middle finger F3 and index finger F2 are released, the negative pressure generated within the syringe 1 causes the piston rod 4 to return to its original position (the position before the negative pressure was generated) together with the slide lever 110b that is engaged with it. However, since the abutment piece 111b of the slide lever 110b abuts against the inner edge of the opening 11a of the base member 110a, the movement of the slide lever 110b is restricted, and therefore the movement of the piston rod 4 is also restricted, and as a result, the negative pressure state within the syringe 2 is maintained.

[0076] In this state, when vibration switch 123 is operated using, for example, thumb F1 of one hand, the rotational motion of motor 121 is converted into linear motion by motion conversion mechanism 122 and transmitted to base member 110a, causing syringe 2 to vibrate back and forth. As a result, the negative pressure within syringe 2 and the vibration of injector 1 cause the sample to be sucked into syringe 2 from injection needle 5 inserted into the object.

[0077] In this way, in the sample collection support device 100 of this embodiment 1, by maintaining a negative pressure inside the syringe 1 inserted into the living body and vibrating the syringe 1 back and forth using a vibration means, it is possible to achieve stable and accurate collection of living body cells (or tissues) regardless of the skill of the operator.

[0078] In addition, the sample collection support device 100 can be easily operated with one hand by holding the device 100 with the ring finger F4 and / or little finger F5 of one hand on the gripping portion 100b of the main body portion 100a, and then hooking the middle finger F3 and index finger F2 on the first finger hook portion (lower part of the lever) 10b and the second finger hook portion (upper part of the lever) 20b, respectively, to pull the slide lever 110b and lock it so that the negative pressure state of the syringe 2 is maintained, and then operating the switch 123 of the vibration means 120 with the thumb F1.

[0079] 3A, a pair of finger rests 116a is provided on the top surface of base member 110a, and by grasping the pair of finger rests 116a from the outside on both sides and pressing them inward, base member 110a bends, creating a gap between the opening in base member 110a and slide lever 110b. As a result, the locked state (the state in which the opening in base member 110a and slide lever 110b are engaged) can be released, making it possible to easily release the lock with one hand.

[0080] Furthermore, by providing a slit 117a extending in the vertical direction in the protrusion 112a at the tip of the base member 110a, the bending deformation of the base member caused by operation with the finger rest 116a occurs more easily and effectively, making it possible to release the locked state more easily.

[0081] As described above, the present invention has been illustrated using preferred embodiments of the present invention, but the present invention should not be construed as being limited to these embodiments. It is understood that the scope of the present invention should be interpreted only by the claims. It is understood that a person skilled in the art can implement an equivalent scope based on the description of the present invention and common general technical knowledge from the description of specific preferred embodiments of the present invention. It is understood that the contents of the documents cited in this specification should be incorporated by reference into this specification as if the contents themselves were specifically set forth in this specification. [Industrial Applicability]

[0082] The present invention is useful in that it can provide a sample collection support instrument that enables stable and accurate collection of samples using a syringe, and a sample collection device that combines this with a syringe. [Explanation of symbols]

[0083] 1000 Sample Collection Devices 1 syringe 2 syringes 3 pistons 4 piston rod 5 Syringe needle 100 Sample Collection Support Equipment 100a Main body 100b Grip 101 Case 102 Threaded connection part 110 Holder 110a base member 11a opening 12a Guide opening 13a Crank connection hole 111a Lever mounting portion (base body) 112a Protrusion 113a Connection 114a Connected part 115a Rib 116a Finger rest (for unlocking) 117a Slit (for unlocking) 110b Slide lever 10b Lower part of lever (first finger hook) 20b Upper part of lever (second finger hook) 111b Contact piece 11b Guide protrusion 112b side wall 113b Reinforcing rib 114b Guide part 115b Connecting wall 15b Rod mounting groove 116b Projecting piece 117b sliding plate 120 vibration means 121 Motor 122 Motion conversion mechanism 122a Connected crank 22a Connecting shaft part 22b Pulley connection hole 22c Rotation axis 22d Revolution axis 122b Eccentric rotating pulley 123 Switch 124 Battery

Claims

1. In a sample collection device including a sample collection support instrument body and a syringe, a holder that connects the sample collection support instrument body and the syringe, The injector includes a piston rod and a syringe; the holder has a base member and a slide lever that can advance and retreat relative to the base member, The base member has a protrusion provided at a tip end thereof that can be inserted into the syringe; a connecting portion that is connectable to a connecting portion of the sample collection support device main body and that is provided at a base end thereof and that includes a vibration means for vibrating the holder; and The slide lever has an engaging portion that can engage with the piston rod.

2. The holder according to claim 1 , wherein the slide lever is configured to engage with the base member at a position where the slide lever is retracted by a predetermined amount, thereby locking the slide lever against movement in the forward direction.

3. the base member has an opening; The holder according to claim 2 , wherein the slide lever is configured to be locked against movement in the forward direction by engaging with the opening when the slide lever is in the position where it is retracted by the predetermined amount.

4. 4. The holder according to claim 3, wherein the engagement between the slide lever and the opening is achieved by abutting the forward end of the slide lever against a side surface of the opening on the forward side.

5. The slide lever has a first finger rest and / or a second finger rest. The holder according to claim 1 , further comprising a second finger hook for hooking a finger.

6. The holder according to claim 5 , wherein the first finger hook portion is included in the engagement portion.

7. The holder of claim 2 , wherein the base member includes a finger rest to assist in unlocking the lock.

8. The holder according to claim 3 , wherein the base member further comprises a slit at the tip portion for assisting in releasing the lock.

9. The holder of claim 1 , wherein the base member includes a rib portion for hooking onto the syringe.

10. A holder according to any one of claims 1 to 9; the sample collection support tool body provided with a vibration means for vibrating the holder; Equipped with sample collection support equipment.

11. The sample collection support device according to claim 10 , wherein the vibration means comprises a rotary motor and a motion conversion mechanism that converts rotary motion generated by the rotary motor into linear motion.

12. The motion conversion mechanism includes: an eccentric rotary pulley attached to a rotary shaft of the rotary motor; a connecting crank that connects the eccentric rotating pulley and the holder; The sample collection support device of claim 11, comprising:

13. A holder according to any one of claims 1 to 9; The sample collection support device main body; The syringe and A sample collection device comprising:

14. The sample collection device of claim 13 , wherein the sample is a cell.

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