Wet wipes packaging and chemical solution for wet wipes

Abstract

To provide a package for wet wipes that suppresses the decomposition of glycerol fatty acid monoester, and can maintain antibacterial performance of the wiping surface from immediately after its manufacture to the end of use.SOLUTION: A package for wet wipes includes a fabric and a chemical solution. The chemical solution includes a C8-C18 fatty acid as an antibacterial agent, and a glycerol fatty acid monoester, which is a monoester with glycerol. The chemical solution has a pH of less than 7.30.SELECTED DRAWING: None

Description

[Technical Field]

[0001] FIELD OF THE DISCLOSURE The present disclosure relates to packaging for wet wipes and medicinal solutions for wet wipes. [Background technology]

[0002] A wet wipes package containing a medicinal solution containing a glycerin fatty acid monoester as an antibacterial agent is known. For example, Patent Document 1 discloses disinfecting wet tissues (claim 1) characterized in that a nonwoven fabric containing 10 to 100% by weight of cellulose-based fibers is impregnated with an aqueous solution containing polylysine and / or a salt thereof and a glycerin fatty acid ester in an amount 0.5 to 5 times the weight of the nonwoven fabric.

[0003] Furthermore, paragraph

[0022] of Patent Document 1 discloses that "Since polylysine and glycerin fatty acid esters do not easily volatilize into the air, they remain on the human body or objects even after they have been wiped off, exerting their antibacterial effect and maintaining their disinfecting properties. In other words, even if bacteria re-adhere after wiping and disinfection, the antibacterial action continues, preventing recontamination with bacteria." [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 11-113779 Summary of the Invention [Problem to be solved by the invention]

[0005] The inventors of the present application have confirmed that the glycerin fatty acid ester particles decompose and settle over time in the aqueous solution disclosed in Patent Document 1. This means that the amount of glycerin fatty acid ester contained in the aqueous solution disclosed in Patent Document 1 differs between immediately after production of the disinfecting wet tissue package and at the end of use, and therefore the amount of glycerin fatty acid ester remaining on the wiping surface differs between immediately after production of the disinfecting wet tissue package and at the end of use, posing a problem in the antibacterial retention of the wiping surface.

[0006] Therefore, the present disclosure aims to provide a wet wipes package in which glycerin fatty acid monoester is resistant to decomposition and which can impart antibacterial properties to the wiping surface from immediately after the wet wipes package is manufactured until the end of use. [Means for solving the problem]

[0007] The present inventors have discovered a wet wipes package containing a fabric and a medicinal solution, wherein the medicinal solution contains C8 to C 18 and a glycerin fatty acid monoester, which is a monoester of glycerin and a fatty acid having a carbon number of 1 to 3, and the medicinal solution has a pH of less than 7.30. [Effects of the Invention]

[0008] The wet wipes packaging according to the present disclosure contains glycerin fatty acid monoesters that are resistant to decomposition, and can impart antibacterial properties to the wiping surface from immediately after the wet wipes packaging is manufactured until the end of use. DETAILED DESCRIPTION OF THE INVENTION

[0009] Specifically, the present disclosure relates to the following aspects: [Aspect 1] A wet wipes package including a fabric and a medicinal solution, The above chemical solution is an antibacterial agent, C8 to C 18and a glycerin fatty acid monoester, which is a monoester of a fatty acid having a carbon number of The chemical solution has a pH of less than 7.30. A package for the wet wipes.

[0010] In the wet wipes package, the chemical solution has a predetermined pH, which makes the glycerin fatty acid monoester in the chemical solution less likely to decompose. As a result, the glycerin fatty acid monoester is more likely to be contained in the wet wipes immediately after the wet wipes package is manufactured, and even immediately after the wet wipes package is opened, right up to the end of use. When the wet wipes are used to wipe a surface, the glycerin fatty acid monoester is more likely to remain on the surface. This allows the wet wipes package to impart antibacterial properties based on the glycerin fatty acid monoester to the surface to be wiped, right up to the end of use.

[0011] The mechanism by which the glycerin fatty acid monoester becomes less likely to decompose when the chemical solution has a predetermined pH is thought to be as follows. Glycerin fatty acid monoesters have an ester bond between glycerin and a fatty acid. Hydrolysis of the ester bond under alkaline conditions, i.e., saponification (alkaline hydrolysis), is a substantially irreversible reaction, while hydrolysis under acidic conditions, i.e., acid hydrolysis, is an equilibrium reaction, so saponification proceeds more rapidly than acid hydrolysis.

[0012] Therefore, when the pH of the drug solution is alkaline (especially a pH above 7.30), the glycerin fatty acid monoester is rapidly saponified to produce a fatty acid salt. Furthermore, when a cationic substance is present in the drug solution, the fatty acid salt is thought to form aggregates with the cationic substance and precipitate. Note that when no cationic substance is present in the drug solution, the fatty acid salt does not form aggregates and floats in the drug solution, but the fatty acid salt has weaker antibacterial properties than the glycerin fatty acid monoester.

[0013] On the other hand, when the pH of the drug solution is less than 7.30 (particularly, an acidic pH), the acid hydrolysis of the glycerin fatty acid monoester is an equilibrium reaction, and therefore the amount of fatty acids produced by the decomposition of the glycerin fatty acid monoester remains constant, and the fatty acids are less likely to aggregate, precipitate, etc. after the decomposition of the glycerin fatty acid monoester, and are therefore more likely to exhibit their antibacterial properties. From this viewpoint, it is preferable that the chemical solution, and in turn the packaging of the wet wipes, does not contain any precipitate derived from glycerin fatty acid monoesters.

[0014] [Aspect 2] 2. The wet wipes package of claim 1, wherein the medicinal solution has a pH of 3.00 or more and less than 7.00. In the above-mentioned wet wipes packaging, the chemical solution has a predetermined pH, which prevents the chemical solution from irritating the skin of the wet wipes user, while allowing the wet wipes packaging to impart antibacterial properties to the wiping surface from immediately after production until the end of use.

[0015] [Aspect 3] A wet wipes package according to aspect 1, wherein the medicinal solution satisfies the pH requirement both immediately after production and one month after production. In the above-mentioned wet wipes package, the chemical solution meets the specified pH requirement at a specified time, making it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use.

[0016] [Aspect 4] The wet wipes package of aspect 1, wherein the medicinal solution further comprises a surfactant selected from the group consisting of cationic surfactants, anionic surfactants, nonionic surfactants, and zwitterionic surfactants.

[0017] In the wet wipes package, the chemical solution further contains a predetermined surfactant. The chemical solution containing the predetermined surfactant has a low surface tension. As a result, when the wet wipes are used to wipe a surface, the chemical solution tends to spread thinly over the surface, making it easier for the glycerin fatty acid monoester in the chemical solution to remain on the surface, and the predetermined surfactant also tends to remain on the surface. Therefore, the wet wipes clathrate can impart antibacterial properties based on the glycerin fatty acid monoester and the predetermined surfactant to the surface to be wiped, from immediately after production to the end of use.

[0018] Furthermore, when the glycerin fatty acid monoester is present as particles in the chemical solution, a specific surfactant can function as a dispersant that disperses the glycerin fatty acid monoester particles, thereby maintaining the dispersibility of the glycerin fatty acid monoester particles in the chemical solution and preventing the glycerin fatty acid monoester from separating over time.

[0019] Therefore, when the glycerin fatty acid monoester is present as particles, the glycerin fatty acid monoester particles are taken out together with the fabric from immediately after the production of the wet wipes package until the end of use, and when a surface to be wiped is wiped with the wet wipes from immediately after the production of the wet wipes package until the end of use, the glycerin fatty acid monoester particles are likely to migrate from the wet wipes to the surface to be wiped. As described above, the wet wipes package can impart antibacterial properties based on the glycerin fatty acid monoester particles and antibacterial properties based on the specified surfactant to the surface to be wiped from immediately after the production of the wet wipes package until the end of use.

[0020] [Aspect 5] A wet wipes package according to Aspect 4, wherein the medicinal solution comprises the cationic surfactant, and the cationic surfactant comprises a quaternary ammonium salt.

[0021] In the wet wipes package, the chemical solution contains a quaternary ammonium salt as the cationic surfactant, and therefore the wet wipes package can impart antibacterial properties based on the glycerin fatty acid monoester and antibacterial properties based on the quaternary ammonium salt to the wiping surface from immediately after production to the end of use.

[0022] [Aspect 6] The wet wipes package of Aspect 4, wherein the medicinal solution comprises the cationic surfactant, and the cationic surfactant comprises benzalkonium chloride.

[0023] In the wet wipes package, the chemical solution contains benzalkonium chloride as the cationic surfactant, and therefore the wet wipes package can impart antibacterial properties based on glycerin fatty acid monoester and antibacterial properties based on benzalkonium chloride to the wiping surface from immediately after its manufacture to the end of its use.

[0024] [Aspect 7] A wet wipes package according to any one of Aspects 1 to 6, wherein the wet wipes have an antibacterial activity value of 2.0 or more against each of Staphylococcus aureus and Escherichia coli in an antibacterial performance test.

[0025] In the above-mentioned wet wipes packaging, the wet wipes have a predetermined antibacterial activity value in an antibacterial performance test, so the wet wipes packaging can reliably impart antibacterial properties against Staphylococcus aureus and Escherichia coli to the wiping surface from immediately after production until the end of use, and is expected to impart antibacterial properties against gram-positive bacteria and gram-negative bacteria.

[0026] [Aspect 8] The glycerin fatty acid monoester is C8-C 18 7. The wet wipes package according to any one of aspects 1 to 6, comprising a glycerin hydroxy fatty acid monoester, which is a monoester of glycerin and a hydroxy fatty acid having a carbon number of 1 to 2.

[0027] In the above-mentioned wet wipes package, since the glycerin fatty acid monoester is a glycerin hydroxy fatty acid monoester, the wet wipes package can impart high antibacterial properties against gram-positive bacteria and gram-negative bacteria to the wiping surface from immediately after its production to the end of its use.

[0028] [Aspect 9] 9. The wet wipes packaging of claim 8, wherein the glycerin hydroxy fatty acid monoester is glyceryl ricinoleate.

[0029] In the wet wipes package, the glycerin hydroxy fatty acid monoester is glyceryl ricinoleate, so the wet wipes package can impart higher antibacterial properties against gram-positive and gram-negative bacteria to the wiping surface from immediately after production to the end of use.

[0030] [Aspect 10] Aspect 10. The wet wipes packaging of aspect 9, wherein the glycerin fatty acid monoester further comprises at least one of glyceryl undecylenate and glyceryl caprylate.

[0031] In the wet wipes package, the glycerin fatty acid monoester further contains at least one of glyceryl undecylenate and glyceryl caprylate, so that the wet wipes package can impart higher antibacterial properties against gram-positive and gram-negative bacteria to the wiping surface from immediately after production to the end of use.

[0032] [Aspect 11] A chemical solution for wet wipes, The above chemical solution is an antibacterial agent, C8 to C 18 and a glycerin fatty acid monoester, which is a monoester of a fatty acid having a carbon number of The chemical solution has a pH of less than 7.30. The chemical solution for wet wipes is characterized by: The above-mentioned chemical solution for wet wipes has the same effect as that of the first embodiment.

[0033] [Aspect 12] 12. The chemical solution for wet wipes according to claim 11, wherein the chemical solution has a pH of 3.00 or more and less than 7.00. The chemical solution has the same effect as in the second embodiment.

[0034] [Aspect 13] 13. The chemical solution for wet wipes according to claim 11 or 12, wherein the chemical solution satisfies the pH requirement both immediately after production and one month after production. The chemical solution has the same effect as in the third embodiment.

[0035] [Aspect 14] 13. The chemical solution for wet wipes according to claim 11 or 12, further comprising a surfactant selected from the group consisting of cationic surfactants, anionic surfactants, nonionic surfactants, and zwitterionic surfactants. The above-mentioned chemical solution for wet wipes has the same effect as that of the fourth embodiment.

[0036] The wet wipes packaging (hereinafter sometimes simply referred to as the "packaging") and the chemical solution for the wet wipes (hereinafter sometimes simply referred to as the "chemical solution") of the present disclosure will be described in detail below. The chemical solution will also be described in the section on the packaging.

[0037] The package according to the present disclosure includes a fabric and a medicinal solution. The chemical solution includes the following: - Antibacterial agents, C8-C 18 and glycerin fatty acid monoester, which is a monoester of glycerin and a fatty acid having a carbon number of

[0038] The above glycerin fatty acid monoester is C8 to C 18 There are no particular limitations on the monoester as long as it is a monoester of a fatty acid having the carbon number of 1 to 10 and glycerin. The above fatty acids are C8 to C 18 Examples of the hydroxy fatty acid include ricinoleic acid, 12-hydroxystearic acid, 10-hydroxyundecanoic acid, 9-hydroxyundecanoic acid, 8-hydroxyundecanoic acid, 5-hydroxydodecanoic acid, 5-hydroxyundecanoic acid, 5-hydroxydecanoic acid, 4-hydroxydodecanoic acid, 4-hydroxyundecanoic acid, 4-hydroxydecanoic acid, 9-hydroxy-2-decenoic acid, and 5-hydroxy-7-decenoic acid, and glyceryl ricinoleate is preferred from the viewpoint of antibacterial properties.

[0039] In this specification, "antibacterial" means inhibiting the growth of bacteria for a certain period of time, for example, 24 hours, and "sterilization" means removing bacteria.

[0040] The fatty acids are preferably C8 to C 18 Unsaturated fatty acids having a carbon number of C8 to C 12 From the viewpoint of antibacterial properties, it can be a medium-chain unsaturated fatty acid having a carbon number of C8 to C 18 As the unsaturated fatty acid having the number of carbon atoms, for example, undecylenic acid is preferred from the viewpoint of antibacterial properties.

[0041] The above fatty acids are C8 to C 18 Saturated fatty acids having a carbon number of C8 to C 12 From the viewpoint of antibacterial properties, it can be a medium-chain saturated fatty acid having a carbon number of C8 to C 18 Examples of saturated fatty acids having a carbon number of 1 include octanoic acid (caprylic acid), nonanoic acid (pelargonic acid), decanoic acid (capric acid), dodecanoic acid (lauric acid), tetradecanoic acid (myristic acid), pentadecanoic acid (pentadecylic acid), hexadecanoic acid (palmitic acid), heptadecanoic acid (margaric acid), and octadecanoic acid (stearic acid), with octanoic acid (caprylic acid) being preferred from the viewpoint of antibacterial properties.

[0042] The above glycerin fatty acid monoester is C8 to C18 and hydroxy fatty acids with carbon numbers of C8 to C 18 Unsaturated fatty acids with carbon numbers of C8 to C 18 and a saturated fatty acid having a carbon number of C8 to C 18 and hydroxy fatty acids with carbon numbers of C8 to C 18 and unsaturated fatty acids with carbon numbers of C8 to C 18 It is more preferable that the fatty acid contains a saturated fatty acid having a carbon number of 1 to 3, from the viewpoint of imparting higher antibacterial activity against gram-positive bacteria and gram-negative bacteria.

[0043] The chemical solution contains the glycerin fatty acid monoester in an amount of preferably 0.03% by mass or more, more preferably 0.04% by mass or more, and even more preferably 0.05% by mass or more. The chemical solution also contains the glycerin fatty acid monoester in an amount of preferably 3.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 1.0% by mass or less, and even more preferably 0.5% by mass or less. This allows the packaging of the present disclosure to impart antibacterial properties to the wiping surface and provide the wet wipes with an excellent feel.

[0044] The above-mentioned chemical solution has a pH of less than 7.30. The above-mentioned chemical solution also has a pH of preferably 7.20 or less, more preferably less than 7.00, even more preferably 6.79 or less, and even more preferably 6.50 or less. This makes it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use. The pH of the liquid medicinal agent is more preferably 3.00 or higher, even more preferably 3.50 or higher, and even more preferably 3.80 or higher, so that the wet wipe user's skin is less likely to be irritated. The lower limit of the pH of the medicinal solution is set from the viewpoint of protecting the skin of the user, and the medicinal solution has excellent antibacterial properties even if the pH is less than 3.00.

[0045] In this specification, the pH of the chemical solution is measured at 25°C using HM-21P manufactured by DKK-TOA Corporation. Specifically, 100 mL of the chemical solution adjusted to 25°C was poured into a 100 mL high-precision measuring cylinder (1-8561-06) manufactured by AS ONE Corporation, and then the electrode part of the HM-21P calibrated at 25°C was placed into the measuring cylinder to measure the pH.

[0046] The liquid preferably has the above pH one month after production, and more preferably has the above pH both immediately after production and one month after production, which makes it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use. The inventors of the present application have found that the pH of the medicinal solution according to the present disclosure tends to remain largely unchanged one month after production.

[0047] The chemical solution may further contain a surfactant selected from the group consisting of cationic surfactants, anionic surfactants, nonionic surfactants, zwitterionic surfactants, and any combination thereof, thereby enabling the wet wipes to exhibit antibacterial properties based on the surfactant.

[0048] Furthermore, when the glycerin fatty acid monoester is present in the form of particles in the chemical solution, the surfactant helps maintain the dispersibility of the particles. Preferably, the chemical solution further contains a cationic surfactant and / or a nonionic surfactant.

[0049] Examples of the cationic surfactant include quaternary ammonium salts and amine salts, with quaternary ammonium salts being preferred from the viewpoint of antibacterial properties. Examples of the quaternary ammonium salt include benzalkonium chloride, cetrimonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, cetrimonium, dophanium chloride, tetraethylammonium bromide, didecyldimethylammonium chloride, domiphen bromide, lauryltrimonium chloride, and steartrimonium chloride, with benzalkonium chloride being preferred.

[0050] Examples of the anionic surfactants include carboxylates, sulfates, phosphates, and sulfonates. Examples of the carboxylates include potassium salts, sodium salts, triethanolamine salts, and ammonium salts of saturated and unsaturated C12-C18 fatty acids, such as coconut oil fatty acids, hydrogenated coconut oil fatty acids, palm oil fatty acids, hydrogenated palm oil fatty acids, beef tallow fatty acids, and hydrogenated beef tallow fatty acids, as well as alkyl ether carboxylates and N-acylsarcosinates. Examples of the sulfates include higher alkyl ether sulfates, alkylaryl ether sulfates, fatty acid alkanolamide sulfates, and fatty acid monoglyceride sulfates.

[0051] Examples of the phosphates include alkyl phosphates (triethanolamine monolauryl phosphate, dipotassium monolauryl phosphate, etc.), polyoxyethylene alkyl ether phosphates, alkylaryl ether phosphates, etc. Examples of the sulfonates include N-acylaminosulfonates, polyoxyethylene sulfosuccinates, etc.

[0052] Examples of the nonionic surfactant include polyoxyalkylene-based, mono- or diethanolamide-based, sugar-based, and glycerin-based surfactants. Examples of the zwitterionic surfactant include alkylbetaine, amidobetaine, sulfobetaine, hydroxysulfobetaine, amidosulfobetaine, phosphobetaine, imidazolinium betaine, aminopropionic acid, and amino acid zwitterionic surfactants.

[0053] The chemical solution contains the surfactant in an amount of preferably 0.005% by mass or more, more preferably 0.010% by mass or more, and even more preferably 0.013% by mass or more. The chemical solution also contains the surfactant in an amount of preferably 1.000% by mass or less, more preferably 0.500% by mass or less, even more preferably 0.300% by mass or less, and even more preferably 0.100% by mass or less. This facilitates dispersion of the glycerin fatty acid monoester in the chemical solution, and, when the glycerin fatty acid monoester exists as particles in the chemical solution, facilitates dispersion of the glycerin fatty acid monoester particles in the chemical solution. Furthermore, the wet wipes are less likely to feel sticky to the user. Furthermore, the wet wipes can exhibit antibacterial properties based on the surfactant.

[0054] When the glycerin fatty acid monoester is present as particles in the chemical solution, the glycerin fatty acid monoester particles preferably have a peak in the range of 100 to 40,000 nm, more preferably 500 to 1,500 nm, in the chemical solution. This makes it easier for the glycerin fatty acid monoester particles to be contained in the wet wipes package from immediately after production to the end of use, and ultimately makes it easier for the glycerin fatty acid monoester particles to remain on the surface to be wiped when the wet wipes are used to wipe the surface to be wiped, making it easier for the wet wipes package to impart antibacterial properties based on the glycerin fatty acid monoester to the surface to be wiped from immediately after production to the end of use.

[0055] Furthermore, when the glycerin fatty acid monoester is present as particles in the chemical solution, the glycerin fatty acid monoester particles in the above range (preferably 100 to 40,000 nm, more preferably 500 to 1,500 nm) preferably account for 50% by mass or more, more preferably 70% by mass or more, and even more preferably 80% by mass or more of the total in the chemical solution, which makes it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use.

[0056] Furthermore, when the glycerin fatty acid monoester is present as particles in the chemical solution, the chemical solution preferably reaches the peak and / or occupancy rate described above after standing for 1 hour, more preferably after standing for 6 hours, and even more preferably after standing for 24 hours, thereby making it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use.

[0057] As used herein, the particle size of glycerin fatty acid monoester particles is measured as follows. (1) A zeta potential and particle size measurement system ELSZ-2000ZS manufactured by Otsuka Electronics Co., Ltd. is prepared in a thermostatic chamber at 25°C. (2) 3 mL of the drug solution is poured into a glass cell GS-10 (3.5 mL) manufactured by AS ONE Corporation, and the cell is washed. Using a syringe that has been washed with the drug solution, 3 mL of new drug solution is poured into the glass cell, and the particle size distribution is measured.

[0058] The chemical solution preferably has a positive zeta potential. The chemical solution more preferably has a zeta potential greater than 0.0 mV, even more preferably 1.0 mV or greater, and even more preferably 2.0 mV or greater. Furthermore, the chemical solution more preferably has a zeta potential of 20.0 mV or less, even more preferably 15.0 mV or less, and even more preferably 10.0 mV or less. This makes it difficult for the glycerin fatty acid monoester particles dispersed in the chemical solution to settle, making it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use.

[0059] In this specification, the zeta potential of a drug solution is measured as follows. (1) A zeta potential and particle size measurement system ELSZ-2000ZS manufactured by Otsuka Electronics Co., Ltd. is prepared in a thermostatic chamber at 25°C. (2) 3 mL of the chemical solution is poured into a glass cell GS-10 (3.5 mL) manufactured by AS ONE Corporation, and the cell is washed. Using a syringe that has been washed with the chemical solution, 3 mL of new chemical solution is poured into the glass cell, and the zeta potential is measured.

[0060] The liquid medicine preferably has a parallel light transmittance of 30% or more, more preferably 40% or more, even more preferably 50% or more, even more preferably 60% or more, and even more preferably 70% or more. The liquid medicine also preferably has a parallel light transmittance of 100% or less. This makes it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use. The liquid medicine preferably has the above-mentioned parallel light transmittance after being left standing for 1 hour, more preferably after being left standing for 6 hours, and even more preferably after being left standing for 24 hours.

[0061] In this specification, the parallel light transmittance of a chemical solution is measured as follows. (1) A haze meter NDH 7000SPII manufactured by Nippon Denshoku Industries Co., Ltd. is prepared in a thermostatic chamber at 25°C. (2) 12 mL of ion-exchanged water is poured into a 14 mL glass cell (GS-40) manufactured by AS ONE Corporation, and after calibration, 12 mL of the chemical solution is poured into the glass cell, and the parallel light transmittance is measured at 25°C.

[0062] In the package according to the present disclosure, the wet wipes have an antibacterial activity value of preferably 2.0 or more, more preferably 2.3 or more, and even more preferably 2.5 or more in an antibacterial performance test. Furthermore, the chemical solution has an antibacterial activity value of preferably 6.0 or less, and more preferably 4.0 or less in an antibacterial performance test. This makes it easier for the wet wipes package to impart antibacterial properties to the wiping surface from immediately after production to the end of use. The antibacterial activity value is preferably above against at least one of Staphylococcus aureus and Escherichia coli, and more preferably against both Staphylococcus aureus and Escherichia coli.

[0063] Furthermore, from the viewpoint of the effects of the present disclosure, the wet wipes taken out from the package preferably after the package has been left standing for 1 hour, more preferably after the package has been left standing for 6 hours, and even more preferably after the package has been left standing for 24 hours have the above-mentioned antibacterial activity value. Furthermore, in the above-mentioned package, preferably, 10% of the wet wipes on the opening side of the package and 10% of the wet wipes on the bottom side of the package have the above-mentioned antibacterial activity value, in view of the effects of the present disclosure.

[0064] In this specification, the antibacterial performance test is carried out as follows. <Antibacterial processing> (1) Prepare "3.4 Wiping device" as described in the "Test method for disinfection performance of wet wipers" (revised May 13, 2021, https: / / www.jhpia.or.jp / standard / wet_wiper / img / wetwiper_standard05-3.pdf), which is the "voluntary disinfection standard" for wet wipers set by the Japan Sanitary Materials Industry Association, and clean the wiping device according to "3.5 Test carrier." (2) Using wet wipes, carry out "5.5 Wiping Operation." Do not inoculate the test carrier with the bacterial solution. The plate is then transferred to a Petri dish, covered, and allowed to stand at room temperature for 24 hours.

[0065] <Antibacterial test> Antibacterial performance tests are conducted in accordance with JIS Z2801:2010 "Antibacterial processed products - Antibacterial test methods and antibacterial effects." The plate is used as a test piece.

[0066] The above-mentioned medicinal solution may contain antibacterial agents other than glycerin fatty acid monoester and surfactant, such as polyhexamethylene biguanide, polyaminopropyl biguanide, cetylpyridinium chloride, methylparaben, ethylparaben, propylparaben, etc.

[0067] The chemical solution may contain additives that are commonly used in chemical solutions such as wet wipes, cosmetics, and cleaning agents. Examples of the additives include hydrocarbon oils such as liquid paraffin, liquid isoparaffin, squalane, petrolatum, and solid paraffin; natural fats and oils such as beef tallow, lard, and fish oil; synthetic triglycerides such as glyceryl tri-2-ethylhexanoate; ester oils such as isopropyl myristate, isopropyl palmitate, cetyl palmitate, ethyl oleate, oleyl oleate, and octyldodecyl myristate; waxes such as beeswax and carnauba wax; linear and cyclic dimethylpolysiloxanes, polyether-modified dimethylpolysiloxanes, and the like. Silicone derivatives; oily bases such as ceramide, cholesterol, protein derivatives, lanolin, lanolin derivatives, and lecithin; nonionic surfactants other than the components of the present invention, such as polyoxyethylene alkyl ethers, polyethylene glycol fatty acid esters, polyoxypropylene alkyl ethers, polypropylene glycol fatty acid esters, sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid esters, glycerin monofatty acid esters, alkyl polyglucosides, polyoxyethylene polyoxypropylene block polymers, and alkanolamides; anionic surfactants such as soap, alkyl sulfates, alkyl ether sulfates, α-olefin sulfonates, acyl methyl taurines, acyl glutamates, acyl glycines, acyl sarcosines, acyl isethionates, alkyl ether carboxylates, amide ether sulfates, and alkyl phosphates; amphoteric surfactants such as alkyl dimethylaminoacetic acid betaine, amide amino acid salts, and alkyl iminodiacetates; alkyl amine oxides, polyoxyethylene alkyl amine oxides, etc. cationic surfactants other than the components of the present invention, such as alkyltrimethylammonium chloride and dialkyldimethylammonium chloride; hydrochlorides and acetates of alkylamines or amidoamines; inorganic powders such as talc, kaolin, sericite, mica, vermiculite, magnesium carbonate, calcium carbonate, diatomaceous earth, magnesium silicate, calcium silicate, aluminum silicate, barium silicate, strontium silicate, barium sulfate, metal tungstates, silica, zeolite, hydroxyapatite, boron nitride, and ceramics;Examples of suitable pigments include organic powders such as crystalline cellulose, polyethylene, and polytetrafluoroethylene; inorganic pigments such as titanium oxide, zinc oxide, red iron oxide (red iron oxide), ochre, carbon black, cobalt violet, chromium oxide, and ultramarine; pearl pigments such as titanium oxide-coated mica, fish phosphate foil, and colored titanium oxide-coated mica; metal powder pigments such as aluminum powder and copper powder; cosmetic pigments such as Red No. 201, Red No. 227, Orange No. 204, Yellow No. 205, and Blue No. 404; food additive pigments such as Red No. 3, Red No. 106, Yellow No. 4, Yellow No. 5, and Blue No. 1; natural pigments such as zirconium, chlorophyll, and beta-carotene; water-soluble polymers such as alginic acid, carboxyvinyl polymer, carboxymethylcellulose, hydroxypropylmethylcellulose, xanthan gum, and hyaluronic acid; inorganic or organic salts such as magnesium sulfate, sodium chloride, and sodium citrate; pH adjusters such as acids and alkalis; disinfectants other than the components of the present invention; chelating agents; antioxidants; ultraviolet absorbers; natural extracts derived from animals and plants; and fragrances. ;

[0068] The chemical solution may contain water as a solvent in any proportion, and the solvent may be 100 mass % water. The chemical solution may further contain a component other than water as a solvent. Examples of the component other than water include alcohol, such as ethanol. By further containing alcohol as a solvent, the chemical solution can impart disinfecting properties to the wet wipes and improve the solubility of the glycerin fatty acid monoester in the solvent. The glycerin fatty acid monoester tends to exist as particles in the solvent as the water content in the solvent increases, and the glycerin fatty acid monoester tends to exist in the solvent in a dissolved state as the alcohol content in the solvent increases.

[0069] When the chemical solution contains water and alcohol as a solvent, the ratio of water to alcohol, based on a total of 100 parts by mass, is preferably 30 to less than 100 (30 or more and less than 100):70 to 0 (70 or less and more than 0), more preferably 30 to 90:70 to 10, even more preferably 40 to 80:60 to 20, and even more preferably 50 to 70:50 to 30. This tends to make the glycerin fatty acid monoester more soluble in the solvent, depending on the presence of other components.

[0070] The chemical solution may contain a solubilizing agent, such as PEG-40 hydrogenated castor oil or PEG-60 hydrogenated castor oil, for dissolving the poorly water-soluble component in water. The chemical solution may contain a dissolution aid, such as a water-soluble solvent such as glycol or phenoxyethanol, for dissolving the poorly water-soluble component in water, in an amount of, for example, 200% by mass or less, 100% by mass or less, or 50% by mass or less of the glycerin fatty acid monoester. Furthermore, the medicinal solution may be free of water-soluble solvents such as glycol, phenoxyethanol, etc. This allows the wet wipes of the present disclosure to provide a sense of security to people and to be safe for pets, etc.

[0071] Examples of the glycol include ethylene glycol, propylene glycol (1,2-propanediol), 1,3-propanediol, butylene glycol, dipropylene glycol, tripropylene glycol, and 1,2-hexanediol.

[0072] In the wet wipes packaging of the present disclosure, the fabric is not particularly limited as long as it is usable as a substrate for wet wipes, and examples thereof include nonwoven fabrics, woven fabrics, knitted fabrics, and the like. The fabric may contain hydrophobic fibers. When the wet wipes according to the present disclosure contain hydrophobic fibers as fibers constituting the fabric, the wet wipes can have bulkiness, resistance to wear, and the like.

[0073] The hydrophobic fibers include, for example, those commonly used in the art, preferably synthetic fibers, including those containing a single component, such as a single fiber, or those containing multiple components, such as a bicomponent fiber.

[0074] Examples of the above components include polyolefin-based polymers such as polyethylene and polypropylene; polyester-based polymers such as terephthalate-based polymers such as polyethylene terephthalate (PET), polybutylene terephthalate, and polypentylene terephthalate; polyamide-based polymers such as nylon 6 and nylon 6,6; acrylic-based polymers; polyacrylonitrile-based polymers; and modified products thereof.

[0075] The fabric may include hydrophilic fibers. The hydrophilic fibers include cellulosic fibers, such as natural cellulose fibers, regenerated cellulose fibers, refined cellulose fibers, and semi-synthetic cellulose fibers.

[0076] Examples of the natural cellulose fibers include plant fibers such as pulp fibers, seed hair fibers (for example, cotton fibers), bast fibers (for example, hemp), leaf vein fibers (for example, Manila hemp), and fruit fibers (for example, palm).

[0077] The pulp fibers include those known in the art as pulp fibers, such as wood pulp fibers and non-wood pulp fibers. Examples of the wood pulp fibers include softwood pulp fibers and hardwood pulp fibers. Examples of the non-wood pulp fibers include straw pulp fibers, bagasse pulp fibers, reed pulp fibers, kenaf pulp fibers, mulberry pulp fibers, bamboo pulp fibers, hemp pulp fibers, and cotton pulp fibers (e.g., cotton linter fibers).

[0078] Examples of the cotton fiber include Hirsutum cotton fiber (for example, upland cotton), Barbadense cotton fiber, Arboreum cotton fiber, and Helbaceum cotton fiber. The cotton fiber may be organic cotton fiber or Pre-Organic Cotton (trademark) fiber. Organic cotton fiber means cotton that is certified by the Global Organic Textile Standard (GOTS).

[0079] Examples of the regenerated cellulose fibers include rayon, for example, viscose rayon obtained from viscose, polynosic and modal, and cuprammonium rayon (also called "cupra") obtained from a cuprammonium salt solution of cellulose.

[0080] The purified cellulose fiber may be lyocell, specifically, pulp, which is dissolved in an aqueous solution of N-methylmorpholine N-oxide to form a spinning dope (dope), and then extruded into a dilute solution of N-methylmorpholine N-oxide to form fibers. The purified cellulose is commercially available, for example, under the trademark Tencel. The semi-synthetic fibers include semi-synthetic cellulose fibers such as acetate fibers, for example, triacetate and diacetate fibers.

[0081] The nonwoven fabric may be any nonwoven fabric (e.g., spunlace nonwoven fabric, air-through nonwoven fabric, spunbond nonwoven fabric, point-bond nonwoven fabric, etc.) manufactured by a known method such as a dry method, a wet method, a water jet method, a spunbond method, an air-laid method, a needle punch method, or a felt method, and a spunlace nonwoven fabric with high wet strength is preferred.

[0082] In the wet wipes packaging, the chemical solution can be impregnated into the fabric at an impregnation rate commonly used in the art, and the impregnation rate (mass %) [= 100 × (mass of chemical solution) / (mass of fabric)] can be, for example, 100 to 500 mass %. [Example]

[0083] The present disclosure will be described below using examples, but the present disclosure is not limited to these examples. [Manufacturing Example 1] 0.2 parts by mass of RUC-20 (a mixture of glycerin fatty acid monoester, manufactured by Taiyo Fragrance Co., Ltd., glyceryl caprylate, glyceryl undecylenate, and glyceryl ricinoleate), 0.03 parts by mass (0.06 parts by mass, calculated as component amount, input amount) of benzalkonium chloride (Cation G50, manufactured by Sanyo Chemical Industries, Ltd.), and 0.01 parts by mass (0.05 parts by mass, calculated as component amount, input amount) of polyaminopropyl biguanide (COSMOCIL CQ, PAPB, manufactured by Nikko Chemicals Co., Ltd.) were mixed to form Mixture No. 1. Mixture No. 1, which contained 59.69 parts by mass of ion-exchanged water and 40.00 parts by mass of ethanol, was added to Mixture No. 1 while stirring, to produce Chemical Solution No. 1.

[0084] [Manufacturing Example 2] Mixture No. 2 was prepared by mixing 0.2 parts by mass of RUC-20, 0.03 parts by mass of benzalkonium chloride (0.06 parts by mass, calculated as component amounts), 0.01 parts by mass of polyaminopropyl biguanide (0.05 parts by mass, calculated as component amounts), and 0.30 parts by mass of HCO-40 (PEG-40 hydrogenated castor oil, manufactured by Nikko Chemicals Co., Ltd.) as a solubilizer. Mixture No. 2 was added to mixed solution No. 2, which contained 59.39 parts by mass of ion-exchanged water and 40.00 parts by mass of ethanol, while stirring, to prepare drug solution No. 2.

[0085] [Manufacturing Examples 3 to 5] Liquid medicines No. 3 to No. 5 were produced in the same manner as in Production Example 1, except that the formulation was changed as shown in Table 1.

[0086] [Comparative Manufacturing Example 1] 1.00 parts by mass of glyceryl caprylate (Sunsoft No. 700P-2-C, Gly-Cap, manufactured by Taiyo Kagaku Co., Ltd.) as a glycerin fatty acid monoester and 0.25 parts by mass of ε-polylysine (manufactured by JNC Corporation) were mixed to form Mixture No. 6. Mixture No. 6 was added to 98.75 parts by mass of stirred ion-exchanged water, and Mixture No. 6 was mixed with the ion-exchanged water to produce Chemical Solution No. 6. Chemical solution No. 6 corresponds to Example 1 of Patent Document 1.

[0087] [Comparative Production Examples 2 and 3] Solutions No. 7 and No. 8 were produced in the same manner as in Comparative Production Example 1, except that the formulation was changed as shown in Table 1. In Table 1, PG means propylene glycol. Chemical solutions No. 7 and No. 8 correspond to Examples 5 and 6 of Patent Document 1, respectively.

[0088] [Examples 1 to 5 and Comparative Examples 1 to 3] <ph> The pH of each of the chemical solutions No. 1 to No. 8 was measured according to the method described herein. The pH was measured twice, immediately after production of each chemical solution and one hour after production. The measured pH values ​​are shown in Table 1. For Examples 2 to 5, the pH hardly changes between immediately after production and one hour after production, so Table 1 lists only the data one hour after production. Furthermore, in Comparative Examples 2 and 3, similar to Comparative Example 1, the high pH immediately after production tended to decrease over time.

[0089] <Antibacterial activity value> According to the method described herein, the antibacterial activity values ​​(against Escherichia coli and Staphylococcus aureus) of chemical solutions No. 1 to No. 8 were measured using chemical solutions one hour after production. The antibacterial activity values ​​of each chemical solution are shown in Table 1. An antibacterial activity value of more than 2.00 is considered to be acceptable. When measuring the antibacterial activity value, a commercially available nonwoven fabric (basis weight: 38 g / m 2 The impregnation rate of the medicinal solution in the wet wipes package was 236% by mass.

[0090] [Table 1]

[0091] The pH of chemical solutions No. 1 to No. 5 was less than 7.00 both immediately after production and one hour after production. Because chemical solutions No. 1 to No. 5 had a pH of less than 7.00, i.e., were in an acidic condition, it is believed that the glycerin fatty acid monoester was less likely to be saponified and less likely to aggregate and precipitate, allowing the glycerin fatty acid monoester to exert its antibacterial properties. As a result, as shown in Table 1, chemical solutions No. 1 to No. 5 had high antibacterial activity against Escherichia coli and Staphylococcus aureus. Furthermore, even when the pH and particle size distribution of chemical solutions No. 1 to No. 5 were measured 24 hours after production, they generally had the same pH as immediately after production.

[0092] The pH of chemical solutions No. 6 to No. 8 was high immediately after production, exceeding 7, and approached a neutral pH of 7 over time. This is thought to be due to the saponification (alkaline hydrolysis) of the glycerin fatty acid monoester. Furthermore, precipitation occurred in chemical solutions No. 6 to No. 8. This precipitation is thought to be due to the production of fatty acids accompanying the saponification (alkaline hydrolysis) of the glycerin fatty acid monoester, and the aggregation of the fatty acids with the polylysine.

[0093] It is also believed that the antibacterial activity of the glycerin fatty acid monoester and polylysine decreased due to the following mechanism. (i) Polylysine reacts with water to release hydroxide ions into the drug solution, making the drug solution alkaline and exhibiting a high pH. (ii) As a result, saponification (alkaline hydrolysis) of the glycerin fatty acid monoester occurs, forming glycerin and a fatty acid salt. (iii) Polylysine and the fatty acid salt form aggregates, making it difficult for both polylysine and the glycerin fatty acid monoester to exhibit antibacterial activity. As a result, as shown in Table 1, it is believed that chemical solutions No. 6 to No. 8 were inferior in antibacterial activity against Escherichia coli and Staphylococcus aureus.

[0094] [Manufacturing Example 6] Liquid medicines No. 9 to No. 22 were produced in the same manner as in Production Example 1, except that the formulation was changed as shown in Table 2. In Table 2, benzalkonium chloride used was Cation G50 manufactured by Sanyo Chemical Industries, Ltd., and polyaminopropyl biguanide (PAPB) used was COSMOCIL-CQ (trade name) manufactured by Nikko Chemicals Co., Ltd. HCl was a 1.0% aqueous solution of hydrochloric acid (manufactured by Hayashi Pure Chemical Industries, Ltd., for research and experiment use), and NaOH was a 1.0% aqueous solution of sodium hydroxide (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0095] [Examples 6 to 14, Comparative Examples 4 to 6, and Reference Examples 1 and 2] <ph> The pH of each of the chemical solutions No. 9 to No. 22 was monitored over time according to the method described herein. The pH was measured for each chemical solution immediately after production and one month after production. The chemical solutions were stored at 25°C. The measured pH values ​​are shown in Table 2.

[0096] <Antibacterial activity value> According to the method described herein, the antibacterial activity values ​​(against Escherichia coli and Staphylococcus aureus) of chemical solutions No. 9 to No. 22 stored for one month at 25° C. were measured. The antibacterial activity values ​​of each chemical solution are shown in Table 2. When measuring the antibacterial activity value, a commercially available nonwoven fabric (basis weight: 38 g / m 2 The impregnation rate of the medicinal solution in the wet wipes package was 236% by mass.

[0097] [Table 2]

[0098] It can be seen that when the pH of chemical solutions Nos. 9 to 16 is adjusted by adding hydrochloric acid or sodium hydroxide, the pH of the chemical solution is kept on the acidic side, resulting in excellent antibacterial activity. Furthermore, it can be seen from chemical solutions Nos. 15 and 16 that making the pH of the chemical solution alkaline causes precipitation and results in poor antibacterial activity. Furthermore, it can be seen that when the pH of chemical solutions Nos. 17 to 20 is kept on the acidic side, the antibacterial activity is improved compared to chemical solution No. 17. It was confirmed that chemical solutions Nos. 9 to 14 and Nos. 18 to 20 had roughly the same pH three months after production as they did one month after production.

[0099] From the chemical solutions No. 21 and No. 22, it can be seen that hydrochloric acid itself has low antibacterial activity against E. coli, and sodium hydroxide itself has low antibacterial activity against E. coli and Staphylococcus aureus.

[0100] [Example 15] One part by mass of the following compound was mixed with 99 parts of ion-exchanged water, and immediately after mixing, the pH was measured according to the method described herein. The results are shown below. -Citric acid: 4.38 -Phenoxyethanol: 4.44 -Dipropylene glycol: 4.63 -Polyethylene glycol hydrogenated castor oil (Nikko Chemicals, HCO-60): 4.26 -Polyhexamethylene biguanide: 5.00 -Benzalkonium chloride: 8.18 - Cetylpyridinium chloride: 5.71 -Sodium lauryl sulfate: 9.77< / ph> < / ph>

Claims

1. Use of a pH adjuster in a medicinal solution for wet wipes containing fabric, The chemical solution contains C as an antibacterial agent. 8 ~C 18 and a glycerin fatty acid monoester, which is a monoester of a fatty acid having a carbon number of The chemical solution is adjusted with the pH adjuster so that the pH is less than 7.30 both immediately after production and one month after production, The glycerin fatty acid monoester is C 8 ~C 18 and a glycerin hydroxy fatty acid monoester, which is a monoester of a hydroxy fatty acid having a carbon number of 1 to 100 and glycerin. The use as described above for inhibiting decomposition of the glycerin fatty acid monoester.

2. The use according to claim 1, wherein the medicinal solution is adjusted with the pH adjuster so that the pH of the medicinal solution is 3.00 or more and less than 7.00 both immediately after production and one month after production.

3. 2. The use of claim 1, wherein the drug solution further comprises a surfactant selected from the group consisting of cationic surfactants, anionic surfactants, nonionic surfactants, and zwitterionic surfactants.

4. The use according to claim 3, wherein the medicinal solution comprises the cationic surfactant, and the cationic surfactant comprises a quaternary ammonium salt.

5. The use of claim 3, wherein the medicinal solution comprises the cationic surfactant, and the cationic surfactant comprises benzalkonium chloride.

6. The use according to any one of claims 1 to 5, wherein the wet wipes have an antibacterial activity value of 2.0 or more against each of Staphylococcus aureus and Escherichia coli in an antibacterial performance test.

7. 2. The use of claim 1, wherein the glycerin hydroxy fatty acid monoester is glyceryl ricinoleate.

8. 8. The use according to claim 7, wherein the glycerin fatty acid monoester further comprises at least one of glyceryl undecylenate and glyceryl caprylate.

9. As an antibacterial agent, C 8 ~C 18 A method for inhibiting decomposition of a glycerin fatty acid monoester in a chemical solution for wet wipes, the chemical solution comprising a glycerin fatty acid monoester, which is a monoester of glycerin and a fatty acid having a carbon number of adjusting the pH of the drug solution with a pH adjuster so that the pH is less than 7.30 both immediately after production and one month after production; The glycerin fatty acid monoester is C 8 ~C 18 and a glycerin hydroxy fatty acid monoester, which is a monoester of a hydroxy fatty acid having a carbon number of 1 to 100 and glycerin. The method for inhibiting decomposition.

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