Alpha gel containing a glycyrrhetinic acid derivative as a constituent component, a composition containing alpha gel, a method for producing alpha gel, and a cosmetic containing alpha gel

Abstract

(A) glycyrrhetinic acid derivative, (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms; (C) one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants; (D) dipropylene glycol, and (E)Water By forming an α-gel having the above as a constituent component, it becomes possible to incorporate a glycyrrhetinic acid derivative into a dosage form containing a high amount of water, and further provides a technology that promotes the transdermal absorption of the glycyrrhetinic acid derivative.

Description

[Technical Field]

[0001] The present invention relates to an α-gel having a glycyrrhetinic acid derivative as a constituent component, a composition containing the α-gel, a method for producing the α-gel, a transdermal absorption enhancer for a glycyrrhetinic acid derivative, and a cosmetic containing the α-gel. [Background technology]

[0002] Glycyrrhetinic acid derivatives are known as active ingredients with pharmacological activity such as anti-inflammatory effects. To exert their excellent pharmacological activity, it is important that they are absorbed transdermally into the skin, scalp, etc.

[0003] As a technique for promoting transdermal absorption of active ingredients, a combination with a hydrocarbon oil having a surface tension of 29.5 mN / m or less at a temperature of 20°C (Patent Publication No. 5997546) has been proposed, but even better effects were desired.

[0004] Furthermore, because glycyrrhetinic acid derivatives are oil-soluble ingredients, when they are incorporated into external preparations such as cosmetics, the formulation is limited to formulations that can incorporate a high amount of oil, such as creams, and there has been a demand for technology that allows them to be incorporated into other formulations. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Patent No. 5997546 Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention has been made in view of the above circumstances, and aims to provide a technology that makes it possible to incorporate glycyrrhetinic acid derivatives into dosage forms that contain a high amount of water by forming an α-gel containing glycyrrhetinic acid derivatives as a constituent component, and that further promotes the transdermal absorption of glycyrrhetinic acid derivatives. [Means for solving the problem]

[0007] As a result of extensive research into achieving the above-mentioned objectives, the inventors discovered that by adopting a specific configuration, an α-gel containing a glycyrrhetinic acid derivative can be obtained, thereby solving the above-mentioned problems, and thus came up with the present invention.

[0008] Therefore, the present invention provides the following inventions. 1. (A) Glycyrrhetinic acid derivatives, (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms; (C) one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants; (D) dipropylene glycol, and (E)Water Alpha gel having the following as a constituent component. 2. (A) Glycyrrhetinic acid derivative: 0.05 to 1% by mass, (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms; (C) one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants: the total amount of components (B) and (C) is 0.5 to 20% by mass; (D) 2.5 to 40% by mass of dipropylene glycol, and (E)Water A composition comprising α-gel, comprising: 3. (A) Glycyrrhetinic acid derivative: 0.05 to 1% by mass, (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms; (C) one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants: the total amount of components (B) and (C) is 0.5 to 20% by mass; (D) 2.5 to 40% by mass of dipropylene glycol, and (E)Water a method for producing α-gel or a composition containing α-gel, the method comprising the steps of dissolving the above components under heating, mixing them uniformly, and cooling them to room temperature. 4. A transdermal absorption enhancer for glycyrrhetinic acid derivatives (A) containing the α-gel described in 1 as an active ingredient. A cosmetic preparation containing the α gel described in 5.1. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide an α-gel that enables the incorporation of a glycyrrhetinic acid derivative into a dosage form containing a high amount of water and further promotes the transdermal absorption of the glycyrrhetinic acid derivative. It is also possible to provide a composition containing the α-gel, a method for producing the α-gel, a transdermal absorption enhancer for the glycyrrhetinic acid derivative, and a cosmetic containing the α-gel. [Brief explanation of the drawings]

[0010] [Figure 1] Photographs of the appearance of Example 1-1 and Comparative Example 1-1 are shown. [Figure 2] 1 shows the results of DSC for Example 1-1. [Figure 3] 1 shows the results of X-ray scattering analysis of Example 1-1. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention will be described in detail below. Hereinafter, the names of compounds may be described in their cosmetic labeling names. [α Gel] The term "α-gel" as used herein refers to an association of (A) a glycyrrhetinic acid derivative, (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms, and (C) one or more selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, in the presence of (D) dipropylene glycol and (E) water, forming a lamellar bilayer membrane. Specifically, the alkyl chains of the (B) aliphatic alcohol or fatty acid and the alkyl chains of the (A) glycyrrhetinic acid derivative and (C) surfactant form a hexagonal crystal. This hexagonal crystal structure has a bilayer laminate structure, forming an α-type hydrated crystal. The α-type hydrated crystal retains a large amount of water and (D) dipropylene glycol between the layers of the bilayer laminate structure, and exhibits gel-state properties due to the water retention by the network structure of the bilayer membrane.

[0012] [Component (A)] Examples of glycyrrhetinic acid derivatives include stearyl glycyrrhetinate and glycyrrhetinyl stearate, and these can be used alone or in appropriate combinations of two or more. All of these have a hydrophilic group and a hydrophobic group.

[0013] [(B) Component] The component (B) of the present invention is one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms, and can be used alone or in appropriate combination of two or more. These aliphatic groups are preferably linear. By selecting such specific components, an α-gel structure can be formed. Examples of the aliphatic alcohol having 14 to 18 carbon atoms include myristyl alcohol (1-tetradecanol), cetyl alcohol (1-hexadecanol), cetostearyl alcohol, stearyl alcohol (octadecyl alcohol), oleyl alcohol, etc. Of these, cetyl alcohol is preferred. Examples of fatty acids having 14 to 18 carbon atoms include myristic acid, palmitic acid, stearic acid, and oleic acid.

[0014] [(C) component] The component (C) of the present invention is one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, and can be used alone or in appropriate combination of two or more.

[0015] The anionic surfactant is preferably one in which the alkyl chain of the hydrophilic group is of trans type, and one type may be used alone or two or more types may be used in appropriate combination. Examples of such salts include alkyl sulfonates, alkyl sulfates, acylated amino acid salts, polyoxyethylene alkyl ether sulfates, alkylbenzene sulfonates, N-acyl-N-methyl taurine salts such as N-stearoyl-N-methyl taurine salts, α-olefin sulfonates, higher fatty acid ester sulfonates, alkyl ether acetates, polyoxyethylene alkyl ether acetates, fatty acid soaps such as sodium stearate, alkyl phosphate ester salts, acyl glutamates such as N-stearoyl glutamate, N-lauroyl glutamate, N-palmitoyl glutamate, N-lauroyl glutamate, and N-palmitoyl glutamate, stearoyl lactylate salts such as sodium stearoyl lactylate, sodium lauroyl lactylate, N-lauroyl-N-ethyl glycine salts, N-lauroyl sarcosine salts, and N-myristoyl-β-alanine salts. Examples of salts include alkali metals, alkaline earth metals, ammonium salts, alkanolamines, and basic amino acids. Among these, N-acyl-N-methyl taurine salts, N-stearoyl glutamate, stearate, stearoyl lactate, and the like are preferred.

[0016] The cationic surfactant is preferably one in which the alkyl chain of the hydrophilic group is of trans type, and one type can be used alone or two or more types can be used in appropriate combination. Specific examples include quaternary ammonium salts such as alkyltrimethylammonium salts, dialkyldimethylammonium salts, and alkylammonium salts, benzalkonium salts, pyridinium salts, and amidoamine compounds. Examples of counter ions of cationic surfactants include halogen ions such as chloride ions and bromide ions, and methyl sulfate ions (CH3OSO3 -), ethyl sulfate ion (CH3CH2OSO3 - Among them, trimethylstearyl ammonium chloride, hexadecyltrimethyl ammonium chloride, cetyltrimethyl ammonium chloride, etc. are mentioned.

[0017] As the nonionic surfactant, those in which the alkyl chain of the hydrophilic group is of trans type are preferred, and one type can be used alone or two or more types can be used in appropriate combination. Specific examples include polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether, polyoxyethylene behenyl ether, fatty acid esters, glycerin fatty acid esters, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, fatty acid polyoxyethylene alkyl ethers, polyhydric alcohol fatty acid esters, sugar alcohol fatty acid esters, etc. Specific examples include polyoxyethylene glyceryl monostearate, polyoxyethylene stearyl ether, polyethylene glycol monostearate, polyoxyethylene cetyl ether, etc. Among these, PEG-40 glyceryl stearate, α-octadecyl ω-hydroxypoly(oxyethylene), PEG-32 stearate, and ceteth-30 (all cosmetic labeling names) are preferred.

[0018] The amphoteric surfactant is preferably one in which the alkyl chain of the hydrophilic group is of a trans type, and can be used alone or in appropriate combination of two or more. Specific examples include alkyl betaine surfactants such as alkyl dimethyl amino acetic acid betaine, amido betaine surfactants such as alkyl amidopropyl betaine, sulfobetaine surfactants, hydroxy sulfobetaine surfactants, amido sulfobetaine surfactants, phosphobetaine surfactants, imidazolinium betaine surfactants, aminopropionic acid surfactants, amino acid surfactants, and amine oxides. Among these, dimethyl octadecyl amine N-oxide, stearyl dimethyl amine oxide, and the like are preferred.

[0019] Among these, anionic surfactants are preferred, and N-acyl-N-methyl taurine salts and N-stearoyl glutamate salts are more preferred.

[0020] [(D) component] The component (D) of the present invention is dipropylene glycol. By using dipropylene glycol, an α-gel containing a glycyrrhetinic acid derivative can be formed.

[0021] [(E) component] The component (E) of the present invention is water, and is not particularly limited as long as it is water, such as purified water.

[0022] The formation of α-gel can be confirmed by the appearance of a uniform single phase, preferably a thickened uniform single phase, which is characteristic of α-gel, and by the presence of a single phase transition temperature in differential scanning calorimetry (DSC). Furthermore, X-ray scattering analysis can also be used to confirm this.

[0023] [Composition containing α-gel] The present invention relates to (A) a glycyrrhetinic acid derivative: 0.05 to 1 mass %; (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms; (C) one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants: the total amount of components (B) and (C) is 0.5 to 20% by mass; (D) 2.5 to 40% by mass of dipropylene glycol, and (E)Water The present invention provides a composition containing α-gel, which is formulated with the above ingredients. This composition contains the above-mentioned α-gel, and from the viewpoint of α-gel formation, the content of each component is as follows. Note that the following contents also include those that constitute α-gel.

[0024] The content of the component (A) in the composition is 0.05 to 1% by mass, and preferably 0.05 to 0.5% by mass. The total content of components (B) and (C) in the composition is 0.5 to 20% by mass, preferably 0.5 to 12% by mass. The mass ratio of (B):(C) varies depending on the type of surfactant, but is preferably 0.5:1 to 5:1, more preferably 1:1 to 4:1, and most preferably 1.3:1 to 3:1. The content of component (B) in the composition is preferably 0.3 to 16.0% by mass, and the content of component (C) in the composition is preferably 0.2 to 8.0% by mass. The content of the component (D) in the composition is 2.5 to 40% by mass, and preferably 2.5 to 20% by mass.

[0025] The blending mass ratio of component (A): total of components (B) and (C): component (D) is preferably 0.05-1:0.5-20:2.5-40.

[0026] The preferred ranges for each component (C) are shown below. If component (C) is sodium N-acyl-N-methyl taurine, The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20 mass %, more preferably 0.5 to 12 mass %, and the mass ratio of (B):(C) is preferably 1:1 to 5:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 20 mass %, and even more preferably 2.5 to 10 mass %.

[0027] If component (C) is sodium stearoyl glutamate, The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of the components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 3:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0028] If component (C) is sodium stearate, The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0029] If component (C) is sodium stearoyl lactylate, The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0030] When component (C) is trimethylstearylammonium chloride, The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0031] If component (C) is hexadecyltrimethylammonium chloride (cetyltrimethylammonium chloride), The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0032] If component (C) is PEG-40 glyceryl stearate (polyoxyethylene glyceryl monostearate), The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0033] When component (C) is α-octadecyl ω-hydroxypoly(oxyethylene) (polyoxyethylene stearyl ether), The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0034] When component (C) is PEG-32 stearate (polyethylene glycol monostearate), The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0035] If component (C) is Ceteth-30 (polyoxyethylene cetyl ether), The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is 2.5 to 40 mass %, and more preferably 2.5 to 30 mass %.

[0036] When component (C) is dimethyloctadecylamine N-oxide (stearyldimethylamine oxide), The content of the component (A) in the composition is preferably 0.05 to 1 mass %, more preferably 0.05 to 0.5 mass %. The total content of components (B) and (C) in the composition is preferably 0.5 to 20% by mass, and the mass ratio of (B):(C) is preferably 1:1 to 6:1. The content of the component (D) in the composition is preferably 2.5 to 40 mass %, more preferably 2.5 to 30 mass %.

[0037] The content of component (E) in the composition is preferably 58.5 to 96.95 mass %, more preferably 78.5 to 96.0 mass %. By adopting the configuration of the present invention, a composition with such a high water content can be obtained.

[0038] [Optional ingredients] As optional components, various components that can be incorporated into cosmetics, hair growth agents, pharmaceuticals, quasi-drugs, etc. can be incorporated in appropriate amounts within a range that does not impair the effects of the present invention. Examples of such components include oils such as silicone oil, ester oil, and vegetable oil, silicone powder, polymeric compounds, solvents such as ethanol, alcohols such as lower alcohols (having 2 to 5 carbon atoms) and higher alcohols (having 6 to 22 carbon atoms), thickeners, powders, whitening agents, anti-aging agents, moisturizers, preservatives, antibacterial agents, enzymes, and functional ingredients such as plant extracts, as well as fragrances, pigments, pH adjusters, etc. These can be used alone or in appropriate combinations of two or more.

[0039] [Physical properties of compositions containing α-gel] The viscosity of the composition containing α-gel at 25° C. is preferably 1,000 to 10,000 mPa·s. The viscosity is measured using a Brookfield type viscometer, for example.

[0040] [Method of producing α-gel or composition containing α-gel] α-gel or a composition containing α-gel, (A) glycyrrhetinic acid derivative: 0.05 to 1% by mass, (B) one or more selected from aliphatic alcohols and fatty acids having 14 to 18 carbon atoms; (C) one or more surfactants selected from anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants: the total amount of components (B) and (C) is 0.5% by mass or more; (D) 2.5 to 40% by mass of dipropylene glycol, and (E)Water The composition can be produced by the steps of: heating and dissolving the components, mixing them uniformly, and then cooling them to room temperature. The heating temperature is not particularly limited, but 70 to 90°C is preferred. The mixing method is not particularly limited, and a known mixing device can be used. The mixing speed, mixing device, and mixing time are not particularly limited, as long as a single-phase thickened substance is formed. The mixing speed is preferably 150 rpm or higher, and more preferably 200 rpm or higher. The upper limit is not particularly limited, but can be appropriately selected within a range of 10,000 rpm or lower depending on the mixing device, etc. The mixing time is preferably 1 minute or longer, and more preferably 2 to 10 minutes. The mixture is then cooled to room temperature (approximately 20°C).

[0041] [Transdermal absorption enhancer] The gel structure of the present invention has an excellent effect of promoting the transdermal absorption of (A) a glycyrrhetinic acid derivative. Therefore, a transdermal absorption enhancer for (A) a glycyrrhetinic acid derivative is provided, which contains this α-gel as an active ingredient. The preferred ingredients, contents, etc. are as described above.

[0042] [Cosmetics] The above-mentioned α-gel can be blended into cosmetics, and cosmetics containing the above-mentioned α-gel can be provided. This cosmetic may be a composition containing the above-mentioned α-gel. Furthermore, it can also be blended into hair growth agents, pharmaceuticals, quasi-drugs, etc. The amount of α-gel blended in the cosmetic is not particularly limited and can be appropriately selected from the range of 5 to 100% by mass.

[0043] Cosmetics are not particularly limited, but include skin cosmetics and hair cosmetics. Skin cosmetics include makeup cosmetics such as foundations (both solid and liquid), makeup bases, eyeshadows, lipsticks, lip balms, blushers, eyebrow pencils, mascara, eyeliners, and sunscreens, as well as skin care cosmetics such as lotions, emulsions, creams, serums, eye creams, and masks. Other examples include antiperspirants. Hair cosmetics include shampoos, rinses, and treatments. [Example]

[0044] The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, unless otherwise specified, "%" in the composition indicates % by mass, ratio indicates mass ratio, and the amount of each component in the table is the amount converted into a pure content.

[0045] [Examples and Comparative Examples] The following composition was heated to 90°C, mixed, and mixed for 10 minutes using a shaker, and then cooled to room temperature (20°C) to obtain a composition. The formation of α-gel was confirmed for the obtained composition based on the appearance of the composition and the results of DSC measurement, according to the following criteria. The viscosity was measured using a Brookfield type viscometer. [α-gel formation] ◯: The composition had a thickened, uniform, single-phase appearance, and a single phase transition temperature was confirmed by DSC. △: The composition had a uniform single-phase appearance, and a single phase transition temperature was confirmed by DSC. ×: The composition was in two phases or crystals were observed. △ and ○ indicate that gel has formed.

[0046] [Table 1] Photographs of the appearance of Example 1-1 and Comparative Example 1-1 are shown in FIG. The DSC results for Example 1-1 are shown in FIG. The results of the X-ray scattering analysis of Example 1-1 are shown in FIG. Structural analysis also confirmed the formation of α-gel.

[0047] [Table 2]

[0048] [Table 3]

[0049] [Table 4]

[0050] [Table 5]

[0051] [Table 6]

[0052] [Table 7]

[0053] [Table 8]

[0054] [Table 9]

[0055] [Table 10]

[0056] [Table 11]

[0057] [Table 12]

[0058] [Table 13]

[0059] [Test Example 1] (sample) (1) Blank (gel composition in Table 14): Prepared by mixing the following components. (2) Sample (α-gel composition in Table 15): Prepared in the same manner as in the above examples. ○Conditions (N=4) Skin model: 3D cultured epidermal model (EqiSkin TM-large Model) Receiver fluid: 20% PEG400 / PBS(-): collected after 6 hours and 24 hours. ◆Permeation amount (amount transferred into the skin model, average of N=4) The amount of stearyl glycyrrhetinate was measured by high performance liquid chromatography (HPLC). HPLC measurement conditions Column: YMC-Pack Pro C18 (150 x 4.6 mm I.D.) Mobile phase: methanol / ethanol mixture (4:1) Column temperature: 40℃ Injection volume: 10μL Measurement wavelength: 248nm (1) Blank (gel composition): 0.93025 μg / mL (2) Sample (α-gel composition): 8.00075 μg / mL

[0060] [Table 14]

[0061] [Table 15]

[0062] By forming an α-gel containing stearyl glycyrrhetinate as a constituent, the percutaneous absorption of stearyl glycyrrhetinate was promoted.

Claims

1. (A) a glycyrrhetinic acid derivative, (B) one or more selected from aliphatic alcohols having 14 to 18 carbon atoms and fatty acids having 14 to 18 carbon atoms; (C) one or more selected from sodium N-acyl-N-methyl taurate, sodium stearoyl glutamate, sodium stearate, sodium stearoyl lactylate, trimethylstearyl ammonium chloride, hexadecyltrimethylammonium chloride, PEG-40 glyceryl stearate, alpha-octadecyl omega-hydroxypoly(oxyethylene), PEG-32 stearate, ceteth-30, and dimethyloctadecylamine N-oxide, (D) dipropylene glycol, and (E) Water 78.5% by mass or more Alpha gel having the following as a constituent component.

2. The α-gel according to claim 1, wherein the mass ratio of (B):(C) is 0.5:1 to 5:

1.

3. (A) Glycyrrhetinic acid derivative: 0.05 to 1% by mass, (B) one or more selected from aliphatic alcohols having 14 to 18 carbon atoms and fatty acids having 14 to 18 carbon atoms; (C) one or more selected from sodium N-acyl-N-methyl taurate, sodium stearoyl glutamate, sodium stearate, sodium stearoyl lactylate, trimethylstearyl ammonium chloride, hexadecyltrimethylammonium chloride, PEG-40 glyceryl stearate, α-octadecyl ω-hydroxypoly(oxyethylene), PEG-32 stearate, ceteth-30, and dimethyloctadecylamine N-oxide: 0.5 to 12% by mass in total of component (B) and component (C), (D) 2.5 to 20% by mass of dipropylene glycol, and (E) Water 78.5% by mass or more A composition comprising α-gel, comprising:

4. The composition according to claim 3, which is a cosmetic.

5. 5. The composition according to claim 3, wherein the mass ratio of (B):(C) is from 0.5:1 to 5:

1.

6. (A) Glycyrrhetinic acid derivative: 0.05 to 1% by mass, (B) one or more selected from aliphatic alcohols having 14 to 18 carbon atoms and fatty acids having 14 to 18 carbon atoms; (C) one or more selected from sodium N-acyl-N-methyl taurate, sodium stearoyl glutamate, sodium stearate, sodium stearoyl lactylate, trimethylstearyl ammonium chloride, hexadecyltrimethylammonium chloride, PEG-40 glyceryl stearate, α-octadecyl ω-hydroxypoly(oxyethylene), PEG-32 stearate, ceteth-30, and dimethyloctadecylamine N-oxide: 0.5 to 12% by mass in total of component (B) and component (C), (D) 2.5 to 20% by mass of dipropylene glycol, and (E) Water 78.5% by mass or more a method for producing α-gel or a composition containing α-gel, the method comprising the steps of dissolving the above components under heating, mixing them uniformly, and cooling them to room temperature.

7. The method according to claim 6, wherein the mass ratio of (B):(C) is 0.5:1 to 5:

1.

8. A transdermal absorption enhancer for the glycyrrhetinic acid derivative (A) in the α-gel, comprising the α-gel according to claim 1 as an active ingredient.

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