Implantable manually controlled drug delivery device

Abstract

To provide an implantation type manually controlled drug delivery device including a manually controlled drive pump that enables dosage of a constant quantity of drug at a time desired by a patient.SOLUTION: An implantation type manually controlled drug delivery device is convenient in adjusting a medication schedule since drug can be subjected to precisely controlled delivery in the outside after implantation is performed by adjusting a concentration of the drug and an internal volume and a drive frequency of a drug chamber 22. Since a battery is unnecessary and an internal adjustment device for electromagnetic control is unnecessary, the device is friendly to patients and economical.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to implantable drug delivery technology, and more particularly to an implantable drug delivery device having a manually controlled drive pump that allows a patient to administer a metered amount of drug at a time desired by the patient. [Background technology]

[0002] Patients suffering from chronic diseases such as cancer, brain diseases, diabetes, or osteoporosis require long-term, continuous drug therapy for treatment. One type of drug therapy, called chronotherapy, involves precisely injecting drugs at specific times to increase drug absorption and minimize side effects. Specific methods used for chronotherapy include 1) oral administration, 2) injections, and 3) implantable devices.

[0003] Among these, oral administration has the disadvantage of low bioavailability due to the problem that drugs used for chronic diseases denature or become inactive as they pass through the gastrointestinal tract, and severe side effects due to drug exposure in the gastrointestinal tract. While injections are effective, the increased frequency of administration required to maintain drug concentrations in the bloodstream for a long period of time can cause significant stress for patients. Furthermore, implantable devices that deliver drugs through sustained diffusion can deliver drugs over a long period of time, but they suffer from rapid drug release immediately after implantation and an inability to control the amount of drug release after implantation. Implantable devices designed to overcome these issues are equipped with batteries and electronic circuits to control drug release, which increases their volume and may require additional implantation surgery due to battery replacement issues.

[0004] U.S. Patent Publication No. 7,052,488, which relates to an implantable drug delivery device, discloses a technology for adjustable pulsed drug delivery based on multiple drug reservoirs. Each reservoir is filled with drug and sealed with gold foil, which is then mechanically ruptured to release the drug. However, this device requires additional components, such as a controller and battery, which increase the device's volume in order to rupture the gold foil, and it also has the drawback of being unable to reinject the drug.

[0005] Therefore, to overcome these problems, there is a need for the development of an implantable drug delivery device that can be miniaturized because it does not require internal additional devices or batteries, and that can precisely control the drug dosage and schedule externally according to the patient's needs even after implantation.

[0006] Prior art documents

[0007] Patent documents

[0008] (Patent Document 0001) U.S. Patent Publication No. 7,052,488 Summary of the Invention [Problem to be solved by the invention]

[0009] The present invention aims to solve the above-mentioned problems by providing a drug delivery device that does not require internal additional devices or batteries, can be miniaturized, and is manually controlled so that the patient can control the drug dosage and schedule externally even after implantation in the body. [Means for solving the problem]

[0010] The present invention provides an implantable manually controlled drug delivery device, comprising: a drug storage unit for filling and storing a drug; a drug release driver for releasing a predetermined amount of drug from the drug storage unit to the outside of the device through the operation of a manual control button; and a housing that houses the drug storage unit and the drug release driver and forms the external form of the device. The space in the housing where the drug storage unit is located is formed with a drug inlet and a drug delivery port, and the space in the housing where the drug release driver is located is a drive pump space having an opening for up and down movement of a drive pump that pumps the drug, and the drug is filled and released by the pumping in a predetermined amount. The device includes a drug chamber space, and the drug release driver includes an inlet valve connecting the drug storage unit to the drug chamber space, a drug chamber connected to one end of the inlet valve, an outlet valve connecting the drug chamber to a drug outlet, and a drive pump connected to the manual control button to apply pressure to the drug chamber, wherein the drive pump releases the drug in the drug chamber to the outside of the device through the outlet valve and the drug outlet in response to movement of the manual control button, and fills the drug in the drug storage unit into the drug chamber through the inlet valve.

[0011] The present invention also provides an implantable manually controlled drug delivery device, wherein the drive pump includes a piston in contact with the drug chamber; a spring that applies a restoring force to a position where the piston does not apply pressure to the drug chamber; and a manual control button that moves against the restoring force of the spring to a position where the spring applies pressure to the drug chamber.

[0012] The present invention also provides an implantable manually controlled drug delivery device, wherein the driving pump further includes a piston driving force control section, the piston driving force control section including: a notch formed in a housing fixing section that supports the piston; a guide window formed at an angle in the manual control button; a latch that passes through the notch and moves along the guide window, and is formed on the piston in a direction perpendicular to the piston movement direction, controlling the movement of the piston according to the direction of the notch; an internal spring that constitutes the spring, and when the manual control button is pressed, the latch moves along the guide window, making horizontal movements in the notch, and then pushes down the piston when it reaches a bent portion of the notch; and an external spring that constitutes the spring, and when the pressing force on the manual control button is released, returns the manual control button to its original position, and in the process, the latch moves vertically in the notch as it moves along the guide window, and then moves horizontally when it reaches a bent portion of the notch, returning the latch to the position it was in before the pressing force was applied.

[0013] The present invention also provides an implantable manually controlled drug delivery device, wherein the drug storage unit comprises a drug storage cylinder that delivers the drug injected into the drug inlet to the inlet valve.

[0014] The present invention also provides an implantable manually controlled drug delivery device, wherein the housing integrally includes a drug storage tube, a drug injection port connecting pipe, and an inlet valve connecting pipe in the drug storage space, and integrally includes the inlet valve and the outlet valve in the drug release driving space.

[0015] The present invention also provides an implantable manually controlled drug delivery device, wherein the spring-driven pump releases the drug when it is moved up and down.

[0016] The present invention also provides an implantable multi-unit controlled drug delivery device, in which the drug storage unit and the drug release driving unit are arranged in parallel to each other inside the housing, and the drug delivery port, the inlet valve, the drug chamber and the outlet valve are arranged in a straight line.

[0017] The present invention also provides a method for manufacturing a drug delivery device, wherein the drug storage unit and the drug release driving unit are arranged in series within the housing, the drug delivery port, the inlet valve, and the drug chamber are arranged in a straight line, and the drug chamber and the outlet valve are connected in different directions.

[0018] An implantable, manually controlled drug delivery device is provided. [Effects of the Invention]

[0019] The device of the present invention allows precise control of drug delivery externally after implantation by adjusting the drug concentration, the internal volume of the drug chamber, and the number of times of operation, making it easy to adjust the drug administration schedule. Furthermore, it is economical because it does not require an external power source such as a battery, and does not require an internal regulator for electromagnetic control. Furthermore, as long as it is pressed to a certain depth or more, the piston can be pushed out with the same pressure at all times, allowing for the drug to be released at a fixed rate. [Brief explanation of the drawings]

[0020] [Figure 1] 1 is a conceptual diagram of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0021] [Figure 2] 1 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0022] [Figure 3] 1 shows the actual shape of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0023] [Figure 4] 1 is a conceptual diagram showing the appearance of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0024] [Figure 5]1 is a conceptual diagram showing the disassembled components of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0025] [Figure 6] 1 is a conceptual diagram showing an internal cross section of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0026] [Figure 7] FIG. 1 is a conceptual diagram of an implantable manually controlled drug delivery device according to a second embodiment of the present invention.

[0027] [Figure 8] FIG. 10 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device according to a second embodiment of the present invention.

[0028] [Figure 9] FIG. 10 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device having a piston driving force control function according to a second embodiment of the present invention.

[0029] [Figure 10] FIG. 10 is an exploded perspective view of a piston driving force control function unit according to a second embodiment of the present invention.

[0030] [Figure 11] 1 is a graph showing the correlation between the amount of drug delivered and the number of times the implantable manually controlled drug delivery device of the present invention is used. DETAILED DESCRIPTION OF THE INVENTION

[0031] Prior to a detailed description of the present invention, the terms and phrases used in the following specification and claims should not be interpreted in a limited manner in their ordinary or dictionary sense. Therefore, the embodiments described in this specification and the configurations illustrated in the drawings are merely the most preferred embodiments of the present invention and do not represent the entire technical idea of ​​the present invention, and it should be understood that there may be various equivalents and modifications that can replace them at the time of filing this application.

[0032] Hereinafter, the present invention will be described with reference to the accompanying drawings, in which:

[0033] 1 to 6 are conceptual diagrams of an implantable manually controlled drug delivery device with a parallel structure according to a first embodiment of the present invention. FIG. 1 is a conceptual diagram of an implantable manually controlled drug delivery device in which a drug storage unit and a drug release driver are arranged in parallel. FIG. 2 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device according to a first embodiment of the present invention. The implantable manually controlled drug delivery device according to one embodiment of the present invention includes a drug storage unit 10 that fills and discharges drugs; a drug release driver 20 that releases the drugs from the drug storage unit in predetermined amounts outside the device; and a housing 30 that spatially separates and stacks the drug storage unit and the drug release driver adjacent to each other within the housing, forming the external shape of the device. In one embodiment of the present invention, the drug storage unit 10 and the drug release driver 20 are arranged in parallel within the housing, and the drug delivery port, the inlet valve, the drug chamber, and the outlet valve may be arranged in a straight line.

[0034] The drug reservoir 10 of the housing 30 according to one embodiment of the present invention is a space for filling and storing a drug, and may have a drug inlet 11 on an outer wall and a drug delivery port 15 on an inner wall facing the drug release driver. The space in the housing where the drug release driver 20 is installed includes a drive pump space having an opening for vertical movement to pump the drug delivered from the drug delivery port 15, and a drug chamber 22 space that fills the device with a predetermined amount of drug by pumping and then releases it to the outside. In one embodiment of the present invention, the drug inlet 11 may protrude from the housing 30 so that drug can be injected even after the device is implanted in the body.

[0035] In one embodiment of the present invention, the drug storage unit 10 includes a drug reservoir 13 that receives drug from the drug inlet 11 and delivers the drug to the drug delivery port 15, a drug inlet connecting pipe 12 that connects the drug inlet 11 and the drug storage reservoir 13, and a drug delivery port connecting pipe 14 that connects the drug storage reservoir 13 and the drug delivery port 15.

[0036] The drug release driving unit 20 includes an inlet valve 21 connected to the drug delivery port 15 to allow the drug to flow in one direction, a drug chamber 22 connected at one end to the drug outlet of the inlet valve, an outlet valve 23 connecting the drug chamber to a drug outlet 16 through which the drug is released from the drug chamber to the outside of the device, and a spring-driven pump 25 that applies pressure to the drug chamber 22 to release the drug in the drug chamber to the outlet valve 23 and removes the pressure applied to the chamber to fill the drug into the drug chamber 22 from the inlet valve 21. The driving pump can release the drug in the drug chamber 22 to the outside of the device through the outlet valve 23 and the drug outlet 16 and fill the drug in the drug storage unit 10 into the drug chamber 22 through the inlet valve 21 by operating a manual control button. In one embodiment of the present invention, the inlet valve 21 and the outlet valve 23 are funnel-shaped to allow the drug to flow in one direction, and may be provided with a backflow prevention membrane at the drug outlet to prevent the drug from flowing in the opposite direction to the forward direction.

[0037] In one embodiment of the present invention, the housing may include the drug storage cylinder 13, the drug main inlet connecting pipe 12, and the drug outlet connecting pipe 14 integrated into the drug storage section 10 space, and the inlet valve 21 and the outlet valve 23 integrated into the drug release driving section space.

[0038] According to one embodiment of the present invention, the spring-driven pump (actuator) 25 includes a piston 26 in contact with the medication chamber 22, a spring 27 that applies a restoring force to position the piston so that it does not apply pressure to the medication chamber, and a manual control button 28 that moves the spring to a position where it applies pressure to the medication chamber against the restoring force of the spring. The drug release process through operation of the spring-driven pump 25 is as follows: (1) When the manual control button 28 is pressed, (2) the piston 26 inside the spring-driven pump 25 moves downward, pushing out the medication filled in the medication chamber 22, and (3) the medication is released to the outside through the medication outlet 16 via the outlet valve 23. Then, (4) the restoring force of the spring 27 returns the piston 26 to its original position, and at this time, the medication stored in the medication storage tube 13 is refilled into the medication chamber 22 through the inlet valve 21.

[0039] In a first embodiment of the present invention, the driving pump further includes a piston driving force control unit, which may include: a notch formed in a housing fixing portion supporting the piston; a guide window formed at an angle in the manual control button; a latch that passes through the notch and moves along the guide window, is formed on the piston in a direction perpendicular to the piston movement direction, and controls the movement of the piston according to the direction of the notch; an internal spring that constitutes the spring, and when the manual control button is pressed, the latch moves along the guide window, making horizontal movements in the notch, and then pushes down the piston when it reaches a bent portion of the notch; and an external spring that constitutes the spring, and when the pressing force on the manual control button is released, returns the manual control button to its original position, and in the process, the latch moves vertically in the notch while moving along the guide window, and then moves horizontally when it reaches a bent portion of the notch, returning the latch to its position before the pressing force was applied.

[0040] Figure 3 shows the actual shape of an implantable manually controlled drug delivery device according to a first embodiment of the present invention, and Figure 4 shows the external appearance of the implantable manually controlled drug delivery device according to the first embodiment of the present invention. Also, Figure 5 shows the disassembled state of the components of the implantable manually controlled drug delivery device according to the first embodiment of the present invention, and Figure 6 shows an internal cross-section of the implantable manually controlled drug delivery device according to the first embodiment of the present invention. The actual structures corresponding to the respective components of Figures 1 and 2 are shown with their respective drawing numbers.

[0041] 7 to 10 are conceptual diagrams of an implantable manually controlled drug delivery device according to a second embodiment of the present invention, which relates to a serial drug delivery device. FIG. 7 is a conceptual diagram of an implantable manually controlled drug delivery device in which a drug storage unit and a drug release driver are arranged in series. In one embodiment of the present invention, the drug storage unit 110 and the drug release driver 120 are arranged in series within the housing 130, and the drug delivery port 115, the inlet valve 121, and the drug chamber 122 are arranged in a straight line, and the directions connecting the drug chamber 122 and the outlet valve 123 may be different from each other. In one implementation, the direction connecting the drug delivery port 115, the inlet valve 121, and the drug chamber 122 and the direction connecting the drug chamber 122 and the outlet valve 123 may be perpendicular to each other, and the drug outlet directions of the inlet valve 121 and the outlet valve 123 may also be perpendicular to each other. 8 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device according to a second embodiment of the present invention. The implantable manually controlled drug delivery device according to one embodiment of the present invention includes a drug storage unit 110 that fills and discharges drugs; a drug release drive unit 120 that releases the drug from the drug storage unit in predetermined amounts outside the device; and a housing 130 that spatially separates the drug storage unit and the drug release drive unit and stacks them adjacent to each other, forming the external form of the device.

[0042] According to one embodiment of the present invention, the space in the housing 130 where the drug reservoir 110 is installed includes a drug inlet 111 on an outer wall and a drug delivery port 115 on an inner wall facing the drug release driver, and the space in the housing where the drug release driver 120 is installed includes a drive pump space having an opening for vertical movement to pump the drug delivered from the drug delivery port 115, and a drug chamber 122 space that fills and releases a predetermined amount of drug by the pumping. In one embodiment of the present invention, the drug inlet 111 may protrude from the housing 130 so that drug can be injected even after the device is implanted in the body.

[0043] The drug reservoir 110 according to one embodiment of the present invention includes a drug reservoir 113 that receives a drug from the drug inlet 111 and delivers the drug to the drug delivery port 115, a drug inlet connecting pipe 112 that connects the drug inlet 111 and the drug reservoir 113, and a drug delivery port connecting pipe 114 that connects the drug reservoir 113 and the drug delivery port. The drug release driver 120 includes an inlet valve 121 that is connected in series with the drug delivery port 115 to allow the drug to travel in one direction, a drug chamber 122 that has one end connected to the drug outlet of the inlet valve, an outlet valve 123 that connects the drug chamber and the drug delivery port 116, and a spring-driven pump 125. The spring-driven pump applies pressure to the drug chamber 122 to transfer the drug in the drug chamber to the outlet valve 123 and release it to the outside of the device through the drug outlet 116, and removes the pressure applied to the chamber to fill the drug into the drug chamber 122 through the inlet valve 121. According to one embodiment of the present invention, the inlet valve 121 and the outlet valve 123 are funnel-shaped to allow the drug to flow in one direction, and the drug outlet may be provided with a backflow prevention membrane to prevent the drug from flowing in the opposite direction to the forward direction.

[0044] The housing according to one embodiment of the present invention may integrally include the drug storage cylinder 113, the drug inlet connecting pipe 112, and the drug delivery connecting pipe 114 in the drug storage section 110 space, and may integrally include the inlet valve 121 and the outlet valve 123 in the drug release actuator space. The spring-driven pump (actuator) 125 according to one embodiment of the present invention includes a piston 126 in contact with the drug chamber 122, a spring 127 that applies a restoring force to a position where the piston does not apply pressure to the drug chamber, and a manual control button 128 that moves the spring to a position where it applies pressure to the drug chamber against the restoring force of the spring.

[0045] The drug release process through the operation of the spring-driven pump 25 is as follows: (1) When the manual control button 128 is pressed, (2) the piston 126 inside the spring-driven pump 125 moves downward, pushing out the drug filled in the drug chamber 122, and (3) the drug is released to the outside through the outlet valve 123. Then, (4) the piston 126 returns to its original position due to the restoring force of the spring 127, and at this time the drug in the drug storage cylinder 113 is refilled into the drug chamber 122 through the inlet valve 121.

[0046] Figure 9 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device with a piston driving force control function according to the second embodiment of the present invention, and Figure 10 is an exploded oblique view of the piston driving force control function part according to the second embodiment of the present invention. In one embodiment of the present invention, the spring-driven pump further includes a piston driving force control section, which includes: a notch 220 formed in the shape of a "┐" on a housing fixing section that supports the piston; a guide window 200 formed at an angle on the manual control button; a latch 210 that passes through the notch and moves along the guide window, is formed on the piston in a direction perpendicular to the piston movement direction, and controls the movement of the piston according to the direction of the notch; an inner spring 127-2 that constitutes the spring and, when the manual control button is pressed, the latch moves horizontally within the notch as it moves along the guide window and then pushes down the piston when it reaches a bent portion of the notch; and an outer spring 127-1 that constitutes the spring and, when the pressing force on the manual control button is released, returns the manual control button to its original position, and in the process, the latch moves vertically within the notch as it moves along the guide window and then moves horizontally when it reaches a bent portion of the notch, returning the latch to its position before the pressing force was applied.

[0047] In one embodiment of the present invention, the manual control button 128 of the spring-driven pump 125 is not driven unless it is pressed beyond a predetermined depth, and the piston 126 is always pushed with the same force only when it is pressed beyond the predetermined depth. To achieve this, the spring 127 of the spring-driven pump 125 includes an outer spring 127-1 and an inner spring 127-2. The outer spring 127-1 returns the manual control button 128 to its original position, and the inner spring 127-2 pushes down the piston 126. The piston 126 has a latch 210 formed perpendicular to the piston movement direction. When the piston is not driven, the latch 210 is engaged with a notch 220 in a housing fixing portion that supports the piston. Therefore, even if the inner spring 127-2 pushes the piston, the piston does not move and does not apply pressure to the medication chamber 122. The operating principle is described below.

[0048] 9 shows in detail the drug release actuation process of an implantable manually controlled drug delivery device with a piston driving force control function. The latch 210 protrudes through the notch 220 and is restricted in position so that it can only move along the guide window 200 formed at an angle on the manual control button 128. (a) When the manual control button 128 is pressed, (b) the internal spring 127-2 is compressed, but (c) the latch 210 moves along the guide window 200 but cannot deviate from the horizontal direction of the notch 220, preventing the piston 126 from applying pressure to the drug chamber 122. The piston 126 remains unable to apply pressure to the drug chamber 122 due to the latch until the upper surface of the manual control button 128 moves from position A to B. (d) As latch 210 continues to move along guide window 200, when the upper surface of manual control button 128 passes point B, latch 210 reaches the vertical opening of the notch, the internal spring's movement restriction is released, and piston 126 begins to move, applying uniform pressure to medication chamber 122 with constant force. (e) When the medication chamber is pressurized, a fixed amount of medication is released into outlet valve 123. (h) When manual control button 128 is released, (g) piston 126 is returned by the force of external spring 127-1 being pressed and then restored, and (f) inlet valve 121 is opened and the medication is refilled. During this process, (i) latch 210 moves along guide window 200, moving horizontally along notch 200. Through the above operation, the spring-driven pump 125 with driving force control function will not operate unless it is pressed to a certain depth or more, and as long as it is pressed to a certain depth or more, it can always push the piston with the same pressure, allowing it to release a fixed amount of drug.

[0049] Example

[0050] Figure 11 is a graph showing the correlation between the amount of drug delivered and the number of uses of the implantable manually controlled drug delivery device of the present invention. To test the performance of this device, the drug injection performance was tested in an experimental setting (in vitro) rather than in a state where the device was inserted into the body. The results of testing the amount of drug injected according to the number of manually controlled compressions confirmed that 10±1 μl of drug was injected per compression.

[0051] The device of the present invention can be implanted into various body parts or tissues of an animal, e.g., a mammal, either in the body part requiring treatment itself or in a part that can transmit to other parts through the body's functions, e.g., subcutaneously, intramuscularly, or in an organ, abdomen, or arm.

[0052] Thus, the device of the present invention can be implanted in various parts of an animal to deliver drugs, and in another aspect, the present invention also relates to a method for delivering drugs to body parts or tissues of an animal using the drug delivery device of the present invention.

[0053] Although exemplary embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the claims below also fall within the scope of the present invention.

[0054] Unless otherwise defined, all technical terms used in the present invention are used in the same meaning as commonly understood by a person of ordinary skill in the art in the field related to the present invention. The contents of all publications mentioned as references in this specification are incorporated herein by reference. [Explanation of symbols]

[0055] 10, 110: drug reservoir

[0056] 11, 111: Drug injection port

[0057] 12, 112: drug injection port connecting pipe

[0058] 13, 113: Drug storage cylinder

[0059] 14, 114: Drug delivery port connecting tube

[0060] 15, 115: Drug delivery port

[0061] 16, 116: Drug outlet

[0062] 20, 120: Drug release driver

[0063] 21, 121: Inlet valve

[0064] 22, 122: Drug chamber

[0065] 23, 123: Outlet valve

[0066] 25, 125: Spring-driven pump

[0067] 26, 126: Piston

[0068] 27, 127: Spring

[0069] 127-1: External spring

[0070] 127-2: Internal spring

[0071] 200: Guide window

[0072] 210: Bet

[0073] 220: Notch

[0074] 28, 128: Manual control buttons

[0075] 30, 130: Housing

[0076] (1) Press the manual control button (28, 128)

[0077] (2) The piston (26, 126) moves downward.

[0078] (3) Drug release into outlet valve (23, 123)

[0079] (49) The restoring force of the spring (27, 127) recharges the drug chamber (22, 122).

[0080] (a) Press the manual control button 128

[0081] (b) Inner springs 127-2 are crimped together

[0082] (c) The latch 210 moves along the guide window 200 but cannot deviate from the horizontal direction of the notch 220, so that the piston 126 cannot apply pressure to the medication chamber 122.

[0083] (d) When the latch 210 continues to move along the guide window 200 and the upper surface position of the manual control button 128 passes B, the latch 210 reaches the vertical opening of the notch, the internal spring is released from the movement restriction, and the piston 126 starts to move, and the piston always applies a uniform pressure to the medication chamber 122 with the same force.

[0084] (e) When the drug chamber is pressurized, it releases a fixed amount of drug into the outlet valve 123.

[0085] (f) Inlet valve 121 is opened and refilled with drug.

[0086] (g) The piston 126 returns due to the force of the external spring 127-1 being pressed and then restored.

[0087] (h) Release the manual control button 128

[0088] (i) The latch 210 moves along the guide window 200 while moving along the horizontal direction of the notch 200.

Claims

1. 1. An implantable manually controlled drug delivery device comprising: The device comprises a drug reservoir for loading and storing a drug; a drug release driver for releasing the drug from the drug reservoir in predetermined amounts out of the device through the movement of a manual control button; and a housing in which the drug storage unit and the drug release driving unit are stacked and which constitutes the external form of the device; A space in the housing where the drug storage unit is placed is formed with a drug inlet and a drug delivery port, The space of the housing in which the drug release driving unit is installed includes a driving pump space having an opening for up and down movement of a driving pump for pumping the drug, and a drug chamber space that is filled with a predetermined amount of drug by the pumping and then released, the drug release driving unit includes an inlet valve connecting the drug storage unit with a drug chamber space, a drug chamber connected to one end of the inlet valve, an outlet valve connecting the drug chamber with a drug outlet, and a driving pump connected to the manual control button to apply pressure to the drug chamber; The drive pump is a piston (126) in contact with the medication chamber; a spring (127) that applies a restoring force to the piston in a position where it does not apply pressure to the medication chamber; a manual control button (128) operable to move the spring to a position where it applies pressure to the medication chamber against the restoring force of the spring; and a notch (220) formed in the housing fixing part that supports the piston; a guide window (200) formed inclined on the manual control button; a latch (210) that passes through the notch and moves along the guide window, and is formed on the piston in a direction perpendicular to the piston movement direction to control the movement of the piston along the direction of the notch; an internal spring (127-2) that constitutes the spring and that, when the manual control button is pressed, moves the latch along the guide window, moves horizontally in the notch, and then pushes down the piston when it reaches the broken portion of the notch; and and an external spring (127-1) that forms the spring and returns the position of the manual control button to its original state when the pressing force is removed from the manual control button, and in the process, the latch moves along the guide window, moves vertically at the notch, and when it reaches the bent part of the notch, moves horizontally to return the latch to the position before the pressing force was applied. The driving pump releases the drug in the drug chamber to the outside of the device through the outlet valve and the drug outlet by moving the manual control button, and fills the drug in the drug storage section into the drug chamber through the inlet valve, thereby forming an implantable manually controlled drug delivery device.

2. The implantable manually controlled drug delivery device of claim 1 , wherein the drug storage unit comprises a drug storage cylinder that delivers the drug injected into the drug inlet to the inlet valve.

3. the housing integrally includes a drug storage cylinder, a drug injection port connecting pipe, and an inlet valve connecting pipe in the space of the drug storage section; The implantable manually controlled drug delivery device according to claim 1, wherein the inlet valve and the outlet valve are integrally formed in the space of the drug release driving part.

4. 2. The implantable manually controlled drug delivery device of claim 1, wherein the driving pump releases the drug when it moves up and down.

5. the drug storage unit and the drug release driver are arranged in parallel with each other inside the housing; 2. The implantable manually controlled drug delivery device of claim 1, wherein the drug delivery port, the inlet valve, the drug chamber and the outlet valve are arranged in a straight line.

6. the drug storage unit and the drug release driver are arranged in series with each other within the housing; The implantable manually controlled drug delivery device of claim 1, wherein the drug delivery port, the inlet valve, and the drug chamber are arranged in a straight line, and the directions connecting the drug chamber and the outlet valve are formed in different directions from each other.

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