Allergen inactivation composition and functional article containing the same

Abstract

To provide an allergen inactivation composition having an improved action of inactivating allergens such as pollen and mites and a functional article comprising the same.SOLUTION: An allergen inactivation composition comprises at least one of a silver complex of a silver particle combined with an amino acid or a silver complex of a silver particle combined with hydroxy acid, with the silver particle having a diameter of 1-100 nm, the amino acid being at least one of histidine, methionine, and cysteine.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to an allergen-inactivating composition and a functional article containing the same.

Background Art

[0002] In recent years, various allergic diseases such as atopic dermatitis and allergic rhinitis have been frequently occurring. As allergens that cause allergic diseases, for example, dead mites, pollen, mold, etc. are known.

[0003] For example, Patent Document 1 proposes a hay fever preventive agent containing a water-swellable clay mineral. Further, Patent Document 2 proposes an allergen inactivator containing a chlorine dioxide gas generation component, an apatite-based compound, and metal ions. According to these hay fever preventive agents and allergen inactivators, it is said that they can directly act on pollen, which is the cause of hay fever, and destroy and detoxify the pollen.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, the pollen allergy preventatives and allergen inactivators described in Patent Documents 1 and 2 do not sufficiently inactivate pollen allergens, and their inactivation of other allergens such as dust mites has not been investigated.

[0006] This invention has been made in view of the above circumstances, and aims to provide an allergen inactivation composition that is excellent in inactivating allergens such as pollen and dust mites, and a functional article containing the same. [Means for solving the problem]

[0007] To solve the above problems, the allergen inactivation composition of the present invention is an allergen inactivation composition comprising at least one of the following: a silver complex in which silver particles and an amino acid are bonded, or a silver complex in which silver particles and a hydroxy acid are bonded, The diameter of the silver particles is 1 to 100 nm. The aforementioned amino acid is characterized by being at least one of histidine, methionine, and cysteine.

[0008] The functional article of the present invention is characterized by containing the allergen inactivating composition.

[0009] The aerial spraying agent of the present invention is characterized by containing the allergen inactivating composition. [Effects of the Invention]

[0010] The allergen inactivating composition of the present invention and functional articles containing the same exhibit excellent inactivation of allergens such as pollen and dust mites. Furthermore, the allergen inactivating composition of the present invention and functional articles containing the same also exhibit excellent antibacterial and antiviral properties. [Brief explanation of the drawing]

[0011] [Figure 1] This figure shows the results of confirming the inactivation effect of the composition obtained in Example 1 against cedar pollen allergens. [Figure 2]This figure shows the results of confirming the inactivation effect of the composition obtained in Example 1 against dust mite allergens. [Modes for carrying out the invention]

[0012] The following describes a first embodiment of the allergen inactivation composition of the present invention.

[0013] The allergen inactivation compositions of the present invention are intended for use against, for example, pollen, dust mites, and mold. Examples of pollen allergens include cedar pollen (Cry j1, Cry j2), cypress pollen (Cha o1, Cha o2), ragweed pollen (Amb a1), buckwheat pollen, goldenrod pollen, and mugwort pollen. For example, cedar pollen allergy is caused by cedar pollen that has taken root in the mucous membranes of the nose, eyes, or throat from the outside. However, the pollen itself is not the antigen; rather, it is caused by the pollen allergy allergen Cry j1 present on the surface of the pollen or the pollen allergy allergen Cry j2 present inside the pollen. The allergen inactivation compositions of the present invention can reduce the antigenicity of these allergens and inactivate them.

[0014] The allergen inactivating composition of the present invention comprises at least one of the following: a silver complex in which silver particles are bonded to an amino acid (amino acid silver complex), or a silver complex in which silver particles are bonded to a hydroxy acid (hydroxy acid silver complex).

[0015] The diameter of the silver particles is 1 to 100 nm, preferably 1 to 10 nm. When the silver particles are of this size, a good silver complex is formed, and silver ions can be effectively eluted, so the allergen inactivation composition of the present invention has excellent allergen inactivation activity.

[0016] The raw material of the silver particles is not particularly limited. For example, a commercially available silver colloid dispersion can be appropriately used. Specifically, as the commercially available silver colloid dispersion, a nano silver dispersion (manufactured by Nippon Ion Co., Ltd.) can be preferably used. This nano silver dispersion is colorless and transparent and contains silver particles with a diameter of about 100 nm, and the concentration of the silver particles is 10,000 ppm to 30,000 ppm.

[0017] When the allergen-inactivating composition of the present invention contains a silver amino acid complex, the amino acid is at least one of histidine, methionine, and cysteine. When the amino acid is histidine, methionine, or cysteine, a good silver amino acid complex is formed and silver ions can be effectively eluted. Therefore, the allergen-inactivating composition of the present invention is excellent in the allergen-inactivating effect.

[0018] When the allergen-inactivating composition of the present invention contains a silver hydroxy acid complex, the hydroxy acid is not particularly limited, but it is preferably at least one of malic acid or citric acid.

[0019] The concentration of the silver complex (silver amino acid complex or silver hydroxy acid complex) in the allergen-inactivating composition of the present invention is preferably 1 ppm or more, and more preferably 10 ppm or more. When the concentration of the silver complex is within this range, the allergen-inactivating effect can be surely achieved. Specifically, the allergen-inactivating composition of the present invention can be appropriately adjusted within the range of, for example, 1 to 10,000 ppm according to its use and the like. The concentration of the silver complex (silver amino acid complex or silver hydroxy acid complex) can be measured by a known method.

[0020] The method for producing the allergen-inactivating composition of the present invention is not particularly limited. For example, a commercially available silver colloid dispersion (concentration of silver particles: 10,000 ppm to 30,000 ppm) is appropriately diluted with purified water (such as RO water), and after adjusting the silver content, histidine, methionine, cysteine as amino acids, or malic acid or citric acid as hydroxy acids is added and stirred to produce it. The addition amount of amino acids and hydroxy acids can also be appropriately adjusted in consideration of the concentration of the above silver complex.

[0021] In addition to the above amino acid silver complex, the allergen-inactivating composition of the present invention can be appropriately formulated with compounding agents commonly used in preparations, such as surfactants, oils, alcohols, humectants, thickeners, preservatives, antioxidants, chelating agents, pH adjusters, fragrances, pigments, ultraviolet absorbers / scatterers, vitamins, essential oils, crude drugs, plant extracts, etc.

[0022] Since the allergen-inactivating composition of the present invention contains the amino acid silver complex or hydroxy acid complex as described above, it is excellent in allergen-inactivating action, and also excellent in antibacterial action, antiviral action, and deodorizing action. In particular, it exhibits an effect more than 10 times superior compared to nano silver particles and silver colloids. Further, the allergen-inactivating composition of the present invention does not change color upon irradiation with light and can maintain its effect for a long period of time.

[0023] Therefore, the allergen-inactivating composition of the present invention can be applied to various functional articles and textile products for which allergen-inactivating action, antibacterial action, and antiviral action are expected.

[0024] Functional articles include various articles. For example, a spray agent filled with the allergen-inactivating composition of the present invention in a liquid state in an aerosol dispenser container, an air spray agent, a filling liquid for a humidifier, a liquid agent for a vaporizer, paper impregnated with the allergen-inactivating composition of the present invention (such as building wallpaper), etc. can be exemplified.

[0025] Specifically, for example, in the case of an aerial spray, a volatile solvent (such as ethanol, dimethyl ether, or isopropyl alcohol) can be appropriately added, and the internal gas pressure can be set to approximately 0.4 to 0.5 MPa. Aerial sprays are preferably of the single-shot spray type.

[0026] For example, in the case of textile products, the allergen-inactivating composition of the present invention in liquid form can be applied to or impregnated into the textile product to create a textile product for allergen inactivation. Specifically, textile products include, for example, sheets for wiping the face or body, masks, and pet products.

[0027] The allergen-inactivating composition of the present invention can be used, for example, in cosmetics, pharmaceuticals, and the like. In pharmaceuticals, it can be suitably used in external skin compositions such as ointments.

[0028] Examples of cosmetics containing the above-mentioned allergen-inactivating composition include cosmetic creams, lotions, toners, serums, pre-makeup products, under-makeup products, gels, facial cleansers, body washes, hairsprays, hair makeup products, and hair gels.

[0029] Furthermore, in pharmaceuticals, it can be suitably used in topical skin compositions such as ointments containing allergen-inactivating compositions.

[0030] Next, a second embodiment of the allergen inactivating composition of the present invention will be described. Some details common to the first embodiment will be omitted from the description.

[0031] To date, the inventors have conducted research on oxygen dissolving solutions and have established a new method for producing such solutions. They have successfully developed an oxygen dissolving solution that, for example, maintains the stability of dissolved oxygen (oxygen inclusion hydrate) even when heated to 100°C, and have obtained patents in the United States and China (Patent Documents 3 and 4).

[0032] Furthermore, the inventors have also established a new method for measuring dissolved oxygen content (Patent Document 5), and have confirmed that the oxygen dissolution solutions in Patent Documents 3 and 4 contain dissolved oxygen (oxygen-encapsulated hydrate) that cannot be measured by conventional methods for measuring dissolved oxygen content, such as the diaphragm electrode method, the Winkler method, and the fluorescence method.

[0033] In a second embodiment of the allergen inactivation composition of the present invention, in addition to the above-mentioned silver complex, the oxygen dissolution solution described in Patent Documents 3 and 4 is included.

[0034] The amount of oxygen dissolved in the allergen inactivation composition can be appropriately adjusted depending on the amount of the silver complex and its intended use.

[0035] Specifically, this oxygen-soluble solution is used in the following steps: (1) A step of adding an oxygen-dissolving amino compound to an oxygen-dissolving solution and heating it at a temperature of 80°C or higher; (2) A step after step (1) above, measuring the concentration of the deoxygenating amino compound contained in the oxygen dissolution solution; (3) A step of calculating the amount of dissolved oxygen contained in the oxygen solution before going through step (1) from the concentration of the deoxidizing amino compound measured in step (2); It has the characteristic that the amount of dissolved oxygen determined by the difference (P1-P2) between the numerical value of dissolved oxygen (ppm) P1 measured by a dissolved oxygen content measurement method including the method, and the numerical value of dissolved oxygen (ppm) P2 measured by one of the dissolved oxygen content measurement methods among the diaphragm method, fluorescence method, and Winkler method, is 50 ppm or more (for example, about 50 ppm to 200 ppm).

[0036] The measurement method described above utilizes the measurement method described in Patent Document 5.

[0037] For example, the deoxidizing amino compound in step (1) can be one or more of the following: carbohydrazide, diethylhydroxylamine, hydroxydiaminobenzene, and isopropylhydroxylamine, with carbohydrazide being particularly preferred.

[0038] Furthermore, in step (1), the heating temperature of the liquid sample containing the deoxidizing amino compound is preferably in the range of 80°C to 120°C. As a general guideline, the heating time can be approximately 3 to 4 hours when heating the oxygen-dissolved solution to 80°C, or 30 minutes to 2 hours when heating to 100°C.

[0039] The method for measuring the concentration of the deoxygenating amino compound in step (2) is not particularly limited, and known methods such as iodine titration (redox titration) can be appropriately employed.

[0040] In step (3), the concentration of the deoxygenating amino compound measured in step (2) is compared with the concentration of the deoxygenating amino compound in step (1), and the amount of dissolved oxygen (P1) contained in the oxygen solution before step (1) can be calculated from the amount of reaction of the deoxygenating amino compound.

[0041] Furthermore, at the time of this application, this oxygen dissolving solution is commercially available under the trade name "WOX" (registered trademark) manufactured by Mediscience Espoir Co., Ltd., and the manufacturing methods described in Patent Documents 3 and 4 can be considered when producing it.

[0042] It is believed that oxygen is dissolved in this oxygen solution in the form of oxygen inclusion hydrates, which are formed by oxygen molecules and water molecules. Here, "oxygen inclusion hydrate" refers to a compound in which oxygen molecules are surrounded by a lattice of water molecules. The oxygen inclusion hydrates contained in this oxygen solution cannot be measured by conventional methods for measuring dissolved oxygen, such as the diaphragm electrode method, the Winkler method, or the fluorescence method, but can be measured by the measurement method described in Patent Document 5.

[0043] In this embodiment of the allergen inactivation composition, the inclusion of the above-mentioned oxygen-soluble solution synergistically enhances the allergen inactivation, antibacterial, and antiviral effects. This is a novel finding that has not been previously known.

[0044] Furthermore, in the allergen inactivation composition of this embodiment, for example, the above-mentioned WOX has approximately three times stronger penetrating and dissolving power compared to purified water, and is characterized by its ability to encapsulate oxygen. As a result, the adhesion of the silver complex to bacteria and viruses is increased, and the effect is enhanced by three times. Similarly, for pollen and allergens, not only is the adhesive strength of the silver complex increased, but the reaction of oxygen with the allergens also enhances the inactivation effect by about three times.

[0045] The allergen inactivation compositions of the present invention are not limited to the embodiments described above. [Examples]

[0046] The allergen inactivation composition of the present invention will be described in detail below with reference to examples, but the present invention is not limited in any way to the following examples.

[0047] <Example 1> Preparation of an allergen-inactivating composition A commercially available silver colloidal dispersion (manufactured by Nippon Ion Co., Ltd.: product name "Nano Silver Dispersion") with a silver concentration of 10,000 ppm and a silver particle diameter of approximately 100 nm was diluted with purified water to adjust the amount of silver to 1,000 ppm. Then, histidine was added as an amino acid and the mixture was stirred to obtain a composition containing an amino acid silver complex.

[0048] <Example 2> Investigation of allergen inactivation effect The composition obtained in Example 1 was used to confirm its inactivating effect on cedar pollen and dust mite allergens.

[0049] Specifically, a test solution was prepared by adding and mixing an allergen solution to a 10 ppm aqueous solution of an amino acid silver complex (sample). After a predetermined time (24 hours), the allergen concentration in the test solution was measured by ELISA.

[0050] Furthermore, we confirmed the neutralization conditions in advance to ensure that allergen concentrations could be measured without being affected by the sample.

[0051] The results are shown in Figures 1 and 2.

[0052] As shown in Figures 1 and 2, the composition prepared in Example 1 was confirmed to be able to inactivate 100% of cedar pollen allergens. Furthermore, the composition prepared in Example 1 was confirmed to inactivate approximately 90% of dust mite allergens.

[0053] <Example 3> Use of oxygen-dissolved solution A composition was obtained in the same manner as in Example 1, except that the purified water was replaced with "WOX" (registered trademark), manufactured by Mediscience Espoir Co., Ltd., as the oxygen dissolving solution.

[0054] This oxygen dissolving solution is prepared according to the method described in Patent Document 5. The following steps: (1) A step of adding an oxygen-dissolving amino compound to an oxygen-dissolving solution and heating it at a temperature of 80°C or higher; (2) After step (1), a step to measure the concentration of the deoxidizing amino compound contained in the oxygen solution; (3) A step of calculating the amount of dissolved oxygen contained in the oxygen solution before going through step (1) from the concentration of the deoxygenating amino compound measured in step (2); The amount of dissolved oxygen, determined by the difference (P1-P2) between the numerical value of dissolved oxygen (ppm) P1 measured by a dissolved oxygen measurement method including the method, and the numerical value of dissolved oxygen (ppm) P2 measured by one of the dissolved oxygen measurement methods among the diaphragm method, fluorescence method, and Winkler method, is approximately 50 ppm to 200 ppm.

[0055] When the inactivation effect of this composition against cedar pollen and dust mite allergens was confirmed using the same method as in Example 2, it was found that the allergen inactivation effect was approximately three times higher.

Claims

1. An allergen inactivation composition comprising at least one of the following: a silver complex in which silver particles are bonded to an amino acid, or a silver complex in which silver particles are bonded to a hydroxy acid, The diameter of the silver particles is 1 to 100 nm. The aforementioned amino acid is at least one of histidine, methionine, and cysteine. Furthermore, it contains an oxygen dissolving solution, The oxygen-soluble solution is prepared by the following process: (1) A step of adding an oxygen-dissolving amino compound to an oxygen-dissolving solution and heating it at a temperature of 80°C or higher; (2) A step after step (1) above, measuring the concentration of the deoxidizing amino compound contained in the oxygen dissolution; (3) A step of calculating the amount of dissolved oxygen contained in the oxygen solution before going through step (1) from the concentration of the deoxygenating amino compound measured in step (2); An allergen inactivating composition characterized in that the amount of dissolved oxygen, determined by the difference (P1-P2) between the numerical value P1 of the dissolved oxygen content (ppm) measured by a dissolved oxygen content measurement method including the diaphragm method, the fluorescence method, and the Winkler method, is 50 ppm or more.

2. The allergen inactivation composition according to claim 1, characterized in that the hydroxy acid is at least one of malic acid or citric acid.

3. The allergen inactivation composition according to claim 1 or 2, characterized in that the concentration of the silver complex is 10 ppm or more.

4. A functional article comprising an allergen inactivating composition according to any one of claims 1 to 3.

5. An aerial spray agent comprising an allergen inactivating composition according to any one of claims 1 to 3.

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