Disinfection and in-situ agglutination-solidification method for the disposal of pathogenic medical waste

Abstract

The present invention is intended to disclose a method for in-situ flocculation and subsequent solidification of biomedical waste, which can simultaneously treat and disinfect solid and fluid samples.The method consists of adding waste samples to an alkaline aqueous solution of metal silicate, followed by adding organic or inorganic acid for flocculation, and solid metal oxide or phosphate in a specified volume and / or weight composition, leading to instant solidification with a microbial disinfection rate of more than 99.9%, and an all-in-one disinfection device for the treatment of biomedical waste.The present disclosure also provides a disinfection-flocculation-solidification and disposal device that contains the disinfection composition.

Description

Technical Field

[0001] The present invention relates to a novel method for efficient aggregation and / or solidification of biomedical waste that can simultaneously process and disinfect solid samples and fluid samples. Specifically, the present invention is a method for disinfecting biomedical waste, which comprises adding a waste sample to an aqueous alkaline solution of metal silicate, followed by adding an inorganic acid or an organic acid to bring it into an aggregated state, and further adding a solid powder based on metal oxide or phosphoric acid in a defined volume and / or weight composition to achieve instantaneous solidification with a microbial disinfection rate of over 99.9%. More specifically, the present invention relates to a disinfection device for the disposal of biomedical waste.

Background Art

[0002] Improper management of infectious waste such as biomedical test samples can lead to the spread of microorganisms / toxins / viruses and further promote the spread of contagious and infectious diseases. According to the WHO意见书(2000), improper management of medical waste such as infected subcutaneous needles and syringes has caused infections associated with hepatitis B (21,000,000 cases), hepatitis C (2,000,000 cases) and HIV (260,000 cases) worldwide. The following description cited from the WHO delves into the importance and necessity of proper medical waste management: "Poor management of medical waste potentially exposes healthcare workers, waste handlers, patients and communities at large to the risks of infection, toxic effects and injuries, as well as environmental contamination. It is essential that all medical waste materials are segregated at the point of generation, properly treated and safely disposed of." (quoted from http: / / www.who.int / topics / medical_waste / en / ).

[0003] Adding coagulants to liquid waste reduces the risk of spills and aerosolization. Solid waste such as cotton, sharp objects, and tissues can also lead to the spread of infection, and the simple absorbents or hypochlorites currently in use are not always able to handle such waste. If the coagulant / gelling agent contains a disinfectant, the waste may be able to be disposed of as unregulated medical waste, which is cheaper than red-bagging. Isolation, transport, and incineration of such disinfected medical waste is easier and safer for healthcare facilities and reduces the cost of medical waste disposal.

[0004] Several strategies have been applied to the management of liquid biological medical waste, including, but are not limited to, sewer disposal methods, chemical treatment using a 1% sodium hypochlorite solution with a minimum contact time of 30 minutes, or 10-14 g of bleaching powder per liter of water, 70% ethanol, 4% formaldehyde, 70% isopropyl alcohol, 25% iodine, or 6% hydrogen peroxide, solidification of liquid waste using dry, highly adsorbent polymers containing sanitizing or disinfecting agents such as chlorine or glutaraldehyde, and closed disposal systems. You can refer to the paper "Liquid biomedical waste management: An emerging concern for physicians, Biswal S, Muller J Med Sci Res 2013, 4, 99-106," which states that culture media containing high microbial loads or high protein content require rigorous disinfection procedures, where inactivation is achieved by using 5.23% sodium hypochlorite at a dilution ratio of 1:10 inside a securely secured container for a minimum of 8 hours, followed by disposal by dropping into a sewer, and then rinsing with a large amount of cold water for at least 10 minutes.

[0005] Solidification systems (highly absorbent polymers) are advantageous over other treatment methods and appear to be a safer disposal method for fluid biomedical waste. Superabsorbent polymers are generally prepared by polymerizing unsaturated carboxylic acids or derivatives, including but not limited to acrylic acids or their metal / ammonium salts and alkyl acrylates, using internal crosslinking agents such as oligofunctional monomers, including but not limited to bisacrylamide, triacrylate, dimethacrylate, or triallylamine.

[0006] Several patents teach the development of such solidification systems. See U.S. Patent No. 7,291,674,B2, which discloses a surface-crosslinked superabsorbent polymer having good liquid retention, permeability, and mechanical strength based on an absorbent structure.

[0007] Refer to U.S. Patent No. 8,450,389,B1, which discloses a method for solidifying liquid medical waste with one or more surface-crosslinked highly absorbent particles in combination with a plurality of second particles for liquid solidification having reduced gel block.

[0008] Another patent, U.S. No. 9533081B1, is disclosed, which includes a similar liquid solidification system having a reduced gel block, comprising a plurality of surface-crosslinked highly absorbent particles, a wound dressing, and a packet, along with a container.

[0009] You can refer to U.S. Patent No. 5,391,351A, which discloses a waste fluid solidification device comprising a hydrophilic xerogel of partially hydrolyzed poly(vinyl acetate), crosslinked poly(vinyl alcohol), crosslinked acrylic acid and hydroxyalkyl methacrylate, polymers and copolymers of ethylene oxide, and polymers and copolymers of acrylamide.

[0010] Refer to U.S. Patent No. 6,797,857,B2, which discloses a solidifying agent for solidifying a certain volume of liquid having a known density, comprising three adsorbents having different densities, thereby achieving controlled stability of a fluid material over its total volume.

[0011] You can refer to U.S. Patent No. 5,424,265A, which discloses a capsule for absorbing liquid waste having a powder adsorbent material placed inside the capsule, wherein the water-soluble body of the capsule leads to the adsorption of liquid waste located inside a suction canister.

[0012] Refer to U.S. Patent No. 9102806B2, which discloses a particulate superabsorbent polymer capable of absorbing water, aqueous liquids and blood, and a method for producing the superabsorbent polymer. The superabsorbent polymer consists of 1 to 10 wt% of any class of thermoplastic polymer selected from polyolefins, polyethylene, linear low-density polyethylene, ethylene acrylic acid copolymer, styrene copolymer, ethylene alkyl methacrylate copolymer, polypropylene, ethylene vinyl acetate copolymer, polyamide, polyester, blends thereof, or copolymers thereof, wherein the surface is treated with a neutralized polyvalent metal salt solution having a pH value similar to that of human skin.

[0013] Refer to U.S. Patent No. 8403904B2, which discloses a superabsorbent polymer comprising a silane derivative having at least one vinyl group or one allyl group bonded to a silicon atom and an internal crosslinking agent consisting of at least one Si-O bond having high centrifugal retention capacity.

[0014] Highly adsorbent polymers, and methods for their preparation and application in liquid solidification, are described in several patents, namely European Patent No. 2739660B2, U.S. Patent No. 20130310251A1, European Patent No. 0273141B1, U.S. Patent No. 8476189B1, JP5527916B2, U.S. Patent No. 5578318A, German Patent No. 69815670T2, and U.S. Patent No. 8821363B1.

[0015] Solid waste, including but not limited to used cotton, tissue paper, syringes, and needles, is generally disinfected, incinerated, or recycled using authorized disinfectants and / or sanitizers. Burial or landfill disposal, disposal in hardening pits, immobilization with plastic foam, sand, cement, or clay, low / medium / high temperature combustion, controlled incineration, steam autoclaves, rotary furnaces, microwave treatment, chemical treatment, crushing, and melting are common practices in the disposal of solid waste (see WHO @ www.who.int / and Medical Waste Management, International Committee of the Red Cross @ www.icrc.org / ). 1-10% solutions of bleach or hypochlorite, sodium hydroxide, or other chemical disinfectants are used to disinfect biomedical waste. Heat, alkaline extinguishers, and microwaves are also used for this purpose.

[0016] Acrylate-based solidifying agents are inexpensive and widely available, but they are not without drawbacks. They generally take 10-15 minutes to fully gel and are not easily recycled. They are non-biodegradable, and some acrylates have been shown to be flammable. Studies have shown that some acrylates and their raw materials may be carcinogenic. The manufacture of acrylics has adverse effects on both health and the environment. Some chemicals used in manufacturing, as well as chemical waste from acrylic plants, are toxic. Hypochlorite (bleaching agents) are not always effective on high-organic-content waste such as blood. Furthermore, no disinfection system capable of instantly treating, immobilizing, and disinfecting both liquid and solid medical waste has been found in the literature. Abbreviations used WHO: World Health Organization min.: minutes wt%: weight percentage NaOH: Sodium hydroxide mg: milligrams mL: milliliter kg: kilogram [Overview of the Initiative] [Problems that the invention aims to solve]

[0017] The first object of the present invention relates to the development of an efficient flocculation or solidification system capable of disinfecting solid and fluid biomedical waste samples.

[0018] Another objective is to provide a simple and cost-effective method for preparing solid and fluid waste for disposal, either in its aggregated or solidified form, at the point in time when care is needed.

[0019] A third objective is to provide a simple, safe, and cost-effective strategy for reducing the risks of spills and occupational exposure from the handling of biomedical waste samples.

[0020] Yet another objective is to develop a method for preparing solid and fluid biomedical waste for disposal by destroying or disinfecting or inactivating infectious pathogens such as bacteria, viruses, etc. through in situ aggregation and subsequent solidification as required.

Means for Solving the Problems

[0021] The present invention intends to disclose a method for disinfecting and aggregating or solidifying biomedical waste. The method includes the use of an alkaline solution of metal silicate, an organic acid or inorganic acid as a flocculant, and a solid powder of a solidifying agent, which, when subjected to mixing with a solid or fluid waste sample in a specified volume and / or weight composition, lead to instantaneous aggregation or instantaneous solidification with a maximum 100% microbial disinfection rate.

[0022] The present invention is a method for disinfection followed by in situ aggregation and solidification by a disinfection-aggregation-solidification and disposal system, wherein the disinfection composition contains four chemical components A, B, C and D, a) A is a metal silicate of an alkali metal selected from the group consisting of sodium, potassium and combinations thereof in its 20-40% aqueous solution at a concentration of 0.5-80% (w / v), b) B is a base at a concentration of 0.1-90 w / v% added to the aqueous solution of A, c) C is an organic acid or inorganic acid completely miscible with water, d) D is a solidifying agent selected from oxide or phosphate-based powders, especially oxides / phosphates of elements such as silicon, titanium, zinc, aluminum or lanthanides, for example cerium or lanthanum, and discloses the method.

[0023] The present invention is a disinfection method for preparing solid and fluid waste collected in a collection container for disposal, combined with the destruction, disinfection or inactivation of microorganisms, especially infectious pathogens including bacteria, fungi, etc., viruses and other poisons, whereby the disposal is considered to be easier, safer and more cost-effective in terms of treatment, handling and transportation.

[0024] The present invention is a method for disinfection - aggregation - solidification of waste, comprising: a) adding B to an aqueous solution of A; b) adding the biomedical waste to be disinfected to the aqueous solution prepared in step (a); c) homogenizing the mixture as in (b) and / or allowing it to stand for 10 to 30 minutes, the resulting mixture being aggregated; and d) adding materials C and D as their solid powders, followed by mixing and / or allowing to stand, the resulting mixture being solidified.

[0025] Another object of the present invention is a method for creating an aggregated or non - pourable environment for fluid medical waste, especially for salts, sugars, saliva, urine, blood, hospital chemicals, etc., such that the risks associated with overflow and occupational exposure are minimized, and further, a treatment for solid medical waste, especially cotton, tissue paper, cotton swabs, needles, etc., such that the risks associated with the deposition of infected untreated samples are minimized, or the mixture of solid waste and liquid waste has a microbial disinfection rate of over 99.9%.

[0026] In another embodiment, the present invention comprises an aqueous solution of metal silicate containing a pH - adjusting base or alkali for the complete disinfection of fluid or solid medical waste; followed by the addition of an organic or inorganic acid for aggregation, or the addition of any oxide - based solid powder as said powder(s) for the instant solidification of a solid or fluid sample containing proteins, microbial cultures, salts or metal ions at high concentrations.

[0027] Finally, the present invention intends to create an all - in - one sample collection - disinfection - solidification device of the required dimensions that can collect solid or liquid samples and immobilize them as a prior pathogenic disinfection for preparation for their disposal and when required.

[0028] These and other features, aspects, and advantages of the subject matter will be better understood by referring to the following description. This summary is provided to introduce the selection of concepts in a simplified form. This summary is not intended to determine any key or essential features of the disclosure, nor is it intended to be used to limit the scope of the subject matter. [Brief explanation of the drawing]

[0029] [Figure 1] Figure 1 illustrates a flocculation method according to one embodiment of the present disclosure, which involves the addition of a saturated salt (NaCl) solution when acetic acid is added: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated salt solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated salt solution, and (d) after the addition of acetic acid for flocculation.

[0030] [Figure 2] Figure 2 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh) with a saturated salt (NaCl) solution: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated salt solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated salt solution, and (d) after the addition of acetic acid for flocculation and silica gel for subsequent solidification.

[0031] [Figure 3] Figure 3 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh) along with a saturated sugar (sucrose) solution: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated sugar solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated sugar solution, and (d) after the addition of acetic acid for aggregation and silica gel for subsequent solidification.

[0032] [Figure 4]Figure 4 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh) to a mixture of saturated salt (NaCl) solution and sugar (sucrose) solution: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 0.5 mL of saturated salt solution + 0.5 mL of saturated sugar solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated salt solution + sugar solution, and (d) after the addition of acetic acid for flocculation and silica gel for subsequent solidification.

[0033] [Figure 5] Figure 5 illustrates a solidification method for waste aqueous solution with the addition of hydrochloric acid and silica gel (chromatographic grade, 60-120 mesh) according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 1 mL of aqueous waste, (c) 1 mL of 50% aqueous NaOH + 1 mL of aqueous waste, and (d) after the addition of hydrochloric acid for flocculation and silica gel for subsequent solidification.

[0034] [Figure 6] Figure 6 illustrates a solidification method including a 6% BSA solution with the addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh) according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 6% BSA solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of 6% BSA solution, and (d) after the addition of acetic acid for flocculation and silica gel for subsequent solidification.

[0035] [Figure 7]Figure 7 illustrates a solidification method according to one embodiment of the present disclosure, which involves a mixture of saturated salt (NaCl) solution and 6% BSA solution upon addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh): (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 0.5 mL of saturated salt solution + 0.5 mL of 6% BSA solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated salt solution + 6% BSA solution, and (d) after the addition of acetic acid for flocculation and silica gel for subsequent solidification.

[0036] [Figure 8] Figure 8 illustrates a solidification method according to one embodiment of the present disclosure, which involves a mixture of saturated salt (NaCl) solution and 6% BSA solution upon addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh): (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 0.5 mL of saturated salt solution + 0.5 mL of 6% BSA solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated salt solution + 6% BSA solution, and (d) after the addition of acetic acid for flocculation and silica gel for subsequent solidification.

[0037] [Figure 9] Figure 9 illustrates a flocculation method according to one embodiment of the present disclosure, which includes saturated potassium dichromate solution when acetic acid is added: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of acetic acid for flocculation.

[0038] [Figure 10]Figure 10 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of saturated potassium dichromate solution with acetic acid and silica gel (chromatographic grade, 60-120 mesh): (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of acetic acid for aggregation and silica gel for subsequent solidification.

[0039] [Figure 11] Figure 11 illustrates a solidification method including iodine solution when acetic acid and silica gel (chromatographic grade, 60-120 mesh) are added according to one embodiment of the present disclosure: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of iodine solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of iodine solution, and (d) after the addition of acetic acid for flocculation and silica gel for subsequent solidification.

[0040] [Figure 12] Figure 12 illustrates a solidification method containing artificial blood upon addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh): (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 1 mL of artificial blood, (c) 1 mL of 50% aqueous NaOH + 1 mL of artificial blood, and (d) after the addition of acetic acid for agglutination and silica gel for subsequent solidification. 6% BSA provides a protein-containing material according to embodiments of this disclosure, in which heme is substituted with an iron(II) complex.

[0041] [Figure 13] Figure 13 illustrates a solidification method including artificial urine with the addition of acetic acid and silica gel (chromatographic grade, 100-200 mesh) according to one embodiment of the present disclosure: (a) 0.5 mL of 28% sodium silicate solution (aqueous) containing 0.15 g of NaOH, (b) 0.5 mL of 50% aqueous NaOH + 0.5 mL of artificial urine, and (c) after the addition of acetic acid for coagulation and silica gel for subsequent solidification.

[0042] [Figure 14] Figure 14 illustrates a solidification method including artificial saliva with the addition of acetic acid and silica gel (chromatographic grade, 100-200 mesh) according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 1 mL of 50% aqueous NaOH + 1 mL of artificial saliva, and (c) after the addition of acetic acid for agglutination and silica gel for subsequent solidification.

[0043] [Figure 15] Figure 15 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of saturated potassium dichromate solution with acetic acid and silica gel (chromatographic grade, 100-200 mesh): (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of acetic acid for aggregation and silica gel for subsequent solidification.

[0044] [Figure 16] Figure 16 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of saturated potassium dichromate solution with acetic acid and silica gel (chromatographic grade, 230-400 mesh): (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of acetic acid for aggregation and silica gel for subsequent solidification.

[0045] [Figure 17]Figure 17 illustrates a gelation method according to one embodiment of the present disclosure, which involves the addition of saturated potassium dichromate solution with sulfuric acid: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of sulfuric acid for gelation and silica gel for subsequent solidification.

[0046] [Figure 18] Figure 18 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of a saturated potassium dichromate solution with sulfuric acid and silica gel (chromatographic grade, 60-120 mesh): (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of sulfuric acid for gelation and silica gel for subsequent solidification.

[0047] [Figure 19] Figure 19 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of saturated potassium dichromate solution with acetic acid and alumina (chromatographic grade, base, 60-325 mesh): (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of acetic acid for aggregation and alumina for subsequent solidification.

[0048] [Figure 20]Figure 20 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of acetic acid and alumina (chromatographic grade, base, 60-325 mesh) to a mixture of saturated salt (NaCl) solution and 6% BSA solution: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, (b) 0.5 mL of saturated salt solution + 0.5 mL of 6% BSA solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated salt + 6% BSA solution, and (d) after the addition of acetic acid for flocculation and alumina for subsequent solidification.

[0049] [Figure 21] Figure 21 illustrates a solidification method according to one embodiment of the present disclosure, which involves the addition of saturated potassium dichromate solution with acetic acid and titania (nano powder, a mixture of rutile and anatase): (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH, (b) 1 mL of saturated potassium dichromate solution, (c) 1 mL of 50% aqueous NaOH + 1 mL of saturated potassium dichromate solution, and (d) after the addition of acetic acid for aggregation and titania for subsequent solidification.

[0050] [Figure 22] Figure 22 illustrates a solidification method including a piece of cotton when acetic acid and silica gel (chromatographic grade, 60-120 mesh) are added according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH + a piece of cotton and (b) after the addition of acetic acid for flocculation and silica gel for solidification.

[0051] [Figure 23] Figure 23 illustrates a flocculation method including tissue paper when acetic acid is added, according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH + one piece of tissue paper and (b) after the addition of acetic acid for flocculation.

[0052] [Figure 24]Figure 24 illustrates a solidification method including tissue paper when acetic acid and silica gel (chromatographic grade, 60-120 mesh) are added according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH + one piece of tissue paper and (b) after the addition of acetic acid for flocculation and silica gel for solidification.

[0053] [Figure 25] Figure 25 illustrates a solidification method including tissue paper when sulfuric acid and silica gel (chromatographic grade, 60-120 mesh) are added according to one embodiment of the present disclosure: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH + a piece of tissue paper and (b) after the addition of sulfuric acid for flocculation and silica gel for solidification.

[0054] [Figure 26] Figure 26 illustrates a solidification method including tissue paper when hydrochloric acid and silica gel (chromatographic grade, 60-120 mesh) are added: (a) 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH + one piece of tissue paper and (b) after the addition of hydrochloric acid for flocculation and silica gel for solidification.

[0055] [Figure 27] Figure 27 illustrates a solidification method including a needle upon addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh) according to one embodiment of the present disclosure: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH + 1 needle and acetic acid for aggregation followed by silica gel for solidification.

[0056] [Figure 28]Figure 28 illustrates a solidification method including a solid cotton swab when acetic acid and silica gel (chromatographic grade, 60-120 mesh) are added according to one embodiment of the present disclosure: (a) 1 mL of 28% aqueous sodium silicate solution containing 0.3 g of NaOH + 1 cotton swab and (b) after the addition of acetic acid for aggregation and silica gel for solidification.

[0057] [Figure 29] Figure 29 illustrates photographs of petri dishes cultured with samples taken according to one embodiment of the present disclosure, (A, D) as a control, (B, E) after the addition of aqueous sodium silicate containing NaOH, and (C, F) after the solidification of aqueous solution and bacterial broth, where (A-C) contain Escherichia coli (E. coli) and (D-F) contain Staphylococcus aureus (S. aureus), ensuring complete disinfection in quantitative experiments.

[0058] [Figure 30] Figure 30 illustrates a large-scale solidification method for a mixture of solid and liquid waste, according to one embodiment of the present disclosure, with the addition of acetic acid and silica gel (chromatographic grade, 60-120 mesh): (a) the mixture of solid and liquid waste in 1 mL of 28% sodium silicate solution (aqueous) containing 0.3 g of NaOH, and (b) after the addition of acetic acid for flocculation and silica gel (60-120 mesh) for subsequent solidification.

[0059] [Figure 31]Figure 31 illustrates a prototype of an all-in-one sample collection-disinfection-solidification-disposal device for liquid samples, comprising (a) four collection vials, one of which is mounted on top of the others; (b) the top vials contain a solid material D (silica is shown as an example), the second vials contain solution C (acetic acid), the third vials contain the collected sample, and the bottom vials are pre-filled with the required amount of solution A (sodium silicate) containing B (NaOH). After the collected sample has been tested, the remaining sample may first be disinfected, which, according to one embodiment of the present disclosure, is done by (c) mixing the sample with solution A+B by breaking the junction between the third compartment and the bottom compartment; (d) agglomerating it by adding solution C by breaking the junction between the second compartment and the third compartment; and (e) subsequently solidifying it by adding solution A by breaking the junction between the top compartment and the second compartment.

[0060] [Figure 32] Figure 32 illustrates a prototype of an all-in-one sample collection-disinfection-solidification-disposal device for solid samples, consisting of (a) three collection vials, one of which is mounted on top of the others; (b) the top vial contains solid material D (silica is shown as an example); the middle vial is filled with solution C (acetic acid); and the bottom vial is pre-filled with the required amount of solution containing solution B. Waste samples can be disinfected by (c) mixing the sample with solutions A+B, then (d) agglomerating it by adding solution C by breaking the junction between the middle and bottom compartments, and (e) solidifying it by adding material A by breaking the junction between the top and middle compartments.

[0061] [Figure 33] Figure 33 illustrates a prototype design of an all-in-one sample collection-disinfection-solidification-disposal device for liquid samples, as shown in Figure 31, according to one embodiment of the present disclosure.

[0062] [Figure 34]Figure 34 illustrates a prototype design of an all-in-one sample collection-disinfection-solidification-disposal device for solid samples, as shown in Figure 32, according to one embodiment of the present disclosure. [Modes for carrying out the invention]

[0063] Those skilled in the art will acknowledge that this disclosure is available for variations and modifications other than those specifically described. It will be understood that this disclosure includes all such variations and modifications. This disclosure also includes all such processes, features, compositions and compounds, individually or collectively, that are referenced or shown herein, as well as any and all combinations of any or more of such processes or features.

[0064] definition For convenience, before further description of this disclosure, certain terms and examples used herein are described herein. These definitions should be interpreted in light of the remainder of this disclosure and as understood by those skilled in the art. The terms used herein have meanings that are recognized and known to those skilled in the art, but for convenience and completeness, certain terms and their meanings are set forth below.

[0065] The articles "a," "an," and "the" are used to refer to one or more (i.e., at least one) grammatical objects of the article.

[0066] The terms “includes” and “contains” are used in an inclusive, open sense, meaning that additional elements may be included. They are not intended to be interpreted as “consisting of only…”. Throughout this specification, unless the context requires otherwise, the terms “includes,” and variations such as “contains” and “contains,” are understood to suggest that they encompass the element or process, or group of elements or processes, being described, but not to suggest that they exclude any other element or process, or group of elements or processes.

[0067] Ratios, concentrations, quantities, and other numerical data may be presented in range format as specified herein. It should be understood that such range formats are used merely for convenience and brevity, and should be interpreted flexibly to include not only the numerical values ​​explicitly stated as range limits, but also all individual numerical values ​​or subranges contained within those ranges, as if each numerical value and subrange were explicitly stated. For example, weight percentages in the range of 0.5 to 80% should be interpreted to include not only the explicitly stated limit of 0.5 to 80%, but also subranges such as 0.6 to 70%, 0.5 to 79%, 1 to 60%, etc., as well as individual quantities within specific ranges, such as 20%, 40%, 55.2%, 60%, 80%, etc.

[0068] This chapter describes the present invention in detail in preferred embodiments. The accompanying illustrations / drawings are for the purpose of illustrating and illustrating preferred embodiments in detail and are not intended to limit the invention to the present invention or its scope or both.

[0069] It has been previously found that adding polyamino acids as an aqueous solution to a stable aqueous nanomaterial sol leads to instantaneous aggregation, and that the aggregation method can be further controlled to act on gelation or solidification under carefully controlled conditions. However, the use of sols and polyamino acids is not very effective for the long-term treatment and standing of biomedical waste. Also, depending on the type of biomedical waste, there is a need to stop the method in the aggregated state or to continue in the solidified state. The present invention provides a method for disinfecting and agglomerating or solidifying biomedical waste, comprising the use of an alkaline solution of metal silicate, an organic or inorganic acid as a flocculant, and a solid powder of a solidifying agent, which leads to instantaneous aggregation or instantaneous solidification with a microbial disinfection rate of up to 100% when subjected to mixing with a solid or fluid waste sample in a specified volume and / or weight composition.

[0070] The present invention provides a disinfection-aggregation-solidification method for the preparation of disposal of solid and fluid waste collected in collection containers, in terms of care, combined with the destruction, disinfection, or inactivation of infectious pathogens, including viruses and other toxins, particularly bacteria and fungi, thereby providing a method in which disposal, including processing, handling, and transport, is considered easier, safer, and more cost-effective. Solidification reduces the risk of spillage and aerosolization, while complete pathogenic disinfection allows the waste to be disposed of as unregulated medical waste, which is less expensive than red bagging. Isolation, transport, and incineration of such disinfected medical waste are easier, safer, and reduce medical waste disposal costs for healthcare facilities.

[0071] Another object of the present invention is to add an organic or inorganic acid to an alkaline solution of a metal silicate containing a biomedical element to be disinfected, leading to aggregation, and further to add an oxide or phosphate of a transition metal, particularly titanium, aluminum, silicon, zinc, cerium, or lanthanum, with or without a binder, wherein the aqueous silicate solution is based to an alkaline pH using a base such that the concentration of the base in water is 0.1 to 90 w / v%, more preferably 0.1 to 1 g / mL, the acid is any organic or inorganic acid selected from acetic acid, hydrochloric acid, sulfuric acid, or phosphoric acid, and the solid oxide or phosphate powder is added in an amount of a minimum of 0.5% (w / v) and a maximum of 1000% (w / v) of the total aqueous volume, resulting in instantaneous disinfection followed by instantaneous aggregation / instantaneous solidification.

[0072] The present invention intends to provide a self-disinfecting solidification method for the treatment and disposal of biomedical waste. The disposal method disclosed herein comprises an aqueous solution of a metal silicate, such as sodium silicate or potassium silicate, at a concentration of 0.5 to 80%, preferably 20 to 40%, in water, wherein the basicizing agent is an alkali metal or alkaline earth metal hydroxide, a basic salt of a metal, and an organic cation, preferably sodium hydroxide or potassium hydroxide, which, when added to a silicate solution in the range of 0.1 to 5 g / mL of silicate, brings the final pH to the range of 9 to 14, and is of the general formula H n The solidifying agent is selected from an acid having X (wherein X is selected from the group of anions, particularly halide ions, acetate ions, sulfate ions, phosphate ions, etc., and n is an integer such that 1 ≤ n ≤ 3), and the solidifying agent is selected from silica, preferably chromatography-grade silica gel powder of 60-400 mesh size, alumina, preferably chromatography-grade alumina powder of 60-200 mesh size, titania, preferably pigment-grade titania in rutile form or anatase form, or a mixture of rutile form and anatase form, zinc oxide, preferably industrial-grade zinc oxide in powder form having a particle size of less than 500 μm, lanthanum phosphate or cerium phosphate as nanopowder, with or without a binder, and is added in a specified volume and / or weight composition to lead to instantaneous solidification with a maximum microbial disinfection rate of 100%.

[0073] In certain embodiments, the present invention relates to providing an environment for fluid medical waste, particularly salt, sugar, saliva, urine, blood, hospital chemicals, etc., in which risks associated with overflow and occupational exposure are minimized; and further relates to the treatment of solid medical waste, particularly cotton, tissue paper, cotton swabs, needles, etc., in which risks associated with the accumulation of infected, untreated samples are minimized, or the mixture of solid and liquid waste has a combined microbial disinfection rate of more than 99.9%.

[0074] Another aspect of the present invention intends to disclose the volume composition of an aqueous solution of metal silicate containing a pH-adjusting base or alkali for complete disinfection of fluid or solid medical waste, following the addition of an oxide / phosphate solid powder as one or more of the said powders for the addition of an acid for flocculation or for the instantaneous solidification of a solid or fluid sample containing proteins, microbial cultures, salts or metal ions at high concentrations.

[0075] Another aspect of the present invention is directed toward creating an all-in-one sample collection-disinfection-solidification device of any size that can collect solid or liquid samples, agglomerate / gel / solidify the samples as needed and when needed, disinfect the samples for preparation for disposal, and immobilize them as needed and when needed, with prior pathogenicity disinfection for preparation for disposal.

[0076] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ by a disinfection-aggregation-solidification and disposal system, wherein the disinfection composition comprises four chemical components A, B, C, and D, a) A is an alkali metal silicate selected from the group consisting of sodium, potassium and combinations thereof in a 20-40% aqueous solution of its concentration 0.5-80% (w / v), b) B is a base with a concentration of 0.1-90 w / v% added to the aqueous solution of A, c) C is an organic or inorganic acid that is completely miscible with water, and d) D is a solidifying agent selected from oxide or phosphate powders, particularly oxides / phosphates of elements such as silicon, titanium, zinc, aluminum, or lanthanides, e.g., cerium or lanthanum.

[0077] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using the disinfection-aggregation-solidification and disposal system disclosed herein, wherein B, a base 、0 0.1~5g / mL AThe present invention provides a method in which, when added to solution A within a certain range, the final pH is reached within the range of 9 to 14, using a hydroxide of an alkali metal or alkaline earth metal selected from the group consisting of sodium hydroxide or potassium hydroxide, a basic salt of a metal, and an organic cation.

[0078] In further embodiments, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using the disinfection-aggregation-solidification and disposal system disclosed herein, wherein C is of the general formula H n The present invention provides a method for an organic or inorganic acid having X (wherein X is selected from the group of anions, particularly halide ions, acetate ions, sulfate ions, and phosphate ions, and n is an integer such that 1 ≤ n ≤ 3).

[0079] In another embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system disclosed herein, wherein the solidifying agent is selected from chromatographic-grade silica gel powder of 60-400 mesh size, chromatographic-grade alumina powder of 60-200 mesh size, pigment-grade titania in rutile or anatase form, or a mixture of rutile and anatase forms, industrial-grade zinc oxide in powder form having a particle size of less than 500 μm, or lanthanum phosphate or cerium phosphate as nanopowder, with or without a binder.

[0080] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system, comprising: a) adding B to an aqueous solution of A; b) adding the biomedical waste to be disinfected to the aqueous solution prepared in step (a); and c) homogenizing the mixture in (b) and / or allowing it to stand for 10 to 30 minutes, characterized in that the resulting mixture is agglomerated; and d) adding material C and material D as their solid powders, followed by mixing and / or allowing it to stand, characterized in that the resulting mixture is solidified.

[0081] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using the disinfection-aggregation-solidification and disposal system disclosed herein, wherein the amount of waste added is less than 1:1000 (v / v) of solution B for liquid waste and any immersable amount of solid waste, or a mixture thereof.

[0082] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system disclosed herein, wherein C is glacial acetic acid, and the amount of C added is 0.1 to 3 mL per 1 mL of all aqueous mixture obtained in step (b).

[0083] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system disclosed herein, wherein solid A is added in a minimum of 1% (w / v) and a maximum of 500% (w / v) of the total aqueous volume in the mixture obtained in step (c).

[0084] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system disclosed herein, wherein the biomedical waste sample used in step (b) is selected from salts, sugars, metal salts and complexes, aqueous waste, hospital chemicals, e.g., iodine, saliva, urine, blood, or any solid sample, in particular from the group consisting of cotton, tissue paper, needles, syringes, or cotton swabs, either alone or in combination thereof, thereby disinfection is carried out by a high pH solution A containing B.

[0085] In one embodiment, the present invention provides a method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system disclosed herein, which assists either agglomeration resulting in a soft aggregated solid when completed in step (c) or solidification resulting in a hard solid when continuing to step (d).

[0086] In one embodiment, the present invention provides a disinfection-aggregation-solidification and disposal device filled with a disinfection composition comprising four chemical components A, B, C, and D disclosed herein, the device comprising a) an upper container or compartment system [Figure 33, 1], b) a second container or compartment system [Figure 33, 2], c) a third container or compartment system [Figure 33, 3], d) a bottom container or compartment system [Figure 33, 4], e) a screw cap connected to the upper container or compartment system [Figure 33, 5], and f) three breakable screw caps [Figure 33, 6], wherein one cap connects the upper container or compartment system to the second container or compartment system, another cap connects the second container or compartment system to the third container or compartment system, and the third cap connects the third container or compartment system to the bottom container or compartment system, including screw caps.

[0087] In one embodiment, the present invention provides a disinfection-aggregation-solidification and disposal device disclosed herein, wherein the upper container or compartment system is filled with a solid powder of material D.

[0088] In one embodiment, the present invention provides a disinfection-aggregation-solidification and disposal device disclosed herein, wherein a second container or compartment system is filled with solution C.

[0089] In one embodiment, the present invention provides a disinfection-aggregation-solidification and disposal device disclosed herein, wherein a third container or compartment system is filled with a biomedical waste sample.

[0090] In one embodiment, the present invention provides a disinfection-aggregation-solidification and disposal device disclosed herein, wherein a bottom container or compartment system is filled with an aqueous solution of A mixed with B disclosed herein.

[0091] In one embodiment, the present invention provides a disinfection-aggregation-solidification and disposal device disclosed herein, wherein the biomedical sample is a solid or liquid waste or a mixture thereof.

[0092] Although the subject matter has been described with reference to specific embodiments, this description is not intended to be construed as limiting. Various modifications of the disclosed embodiments, as well as other embodiments of the subject matter, will be apparent to those skilled in the art when referring to the description of the subject matter. It is therefore considered that such modifications may be made without departing from the spirit or scope of the subject matter as defined. [Examples]

[0093] This disclosure is now illustrated by working examples, which are intended to illustrate the practice of this disclosure and are not intended to be constrained as implying any limitation of the scope of this disclosure. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this disclosure belongs. Similar or equivalent methods and materials may be used in the practice and composition of the disclosed methods, but exemplary methods, devices and materials are described herein. It will be understood that this disclosure is not limited to the specific methods and experimental conditions described herein, and that such methods and conditions may apply.

[0094] The following embodiments are given by illustration and should not be construed as limiting the scope of the invention.

[0095] Example 1. Aggregation of aqueous waste using sodium silicate and acid. Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Aqueous waste (1:1 ratio) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0096] Example 2. Solidification of aqueous waste using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Aqueous waste (1:1 ratio) was added to the solution and thoroughly mixed. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0097] Example 3. Solidification of concentrated salt solution using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A saturated aqueous solution of sodium chloride (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0098] Example 4. Solidification of concentrated sugar solution using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A saturated aqueous solution of sucrose (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0099] Example 5. Solidification of a mixture of concentrated salt solution and sugar solution using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh). Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A mixture of saturated aqueous sodium chloride and sucrose (1:1) was added to the above solution and thoroughly mixed. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0100] Example 6. Solidification of protein-containing aqueous waste using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh). Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A 6% aqueous solution of BSA (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0101] Example 7. Solidification of a concentrated salt solution containing protein using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh). Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A saturated aqueous solution of sodium chloride containing 6% BSA (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0102] Example 8. Aggregation of aqueous solutions containing metal ions and harsh oxidizing agents using sodium silicate and acid. Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A saturated aqueous solution of potassium dichromate (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0103] Example 9. Solidification of aqueous solutions containing metal ions and harsh oxidizing agents using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh). Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). A saturated aqueous solution of potassium dichromate (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0104] Example 10. Solidification of aqueous waste containing hospital chemicals using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh). Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). An aqueous solution of iodine (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous aggregation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0105] Example 11. Solidification of aqueous waste using sodium silicate, acid, and alumina powder (60-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Aqueous waste (1:1 ratio) was added to the solution and thoroughly mixed. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of alumina powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0106] Example 12. Solidification of aqueous waste using sodium silicate, acid, and titania powder (a mixture of anatase and rutile) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Aqueous waste (1:1 ratio) was added to the solution and thoroughly mixed. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of titania powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0107] Example 13. Solidification of aqueous waste using sodium silicate, acid, and zinc oxide powder (particle size <500 μm) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Aqueous waste (1:1 ratio) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of zinc oxide powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0108] Example 14. Solidification of aqueous waste using sodium silicate, acid, and metal phosphate powder. Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Aqueous waste (1:1 ratio) was added to the solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of lanthanum phosphate powder or cerium phosphate powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0109] Example 15. Preparation of artificial saliva Artificial saliva was prepared according to the following two procedures: (i) 1.5 mM Ca(NO3)2, 0.90 mM KH2PO4, 130 mM KCl, and 60 mM Tris buffer were mixed at pH 7.4 (see Kirkham, J.; et al., Self-assembling peptide scaffolds promote enamel remineralization, J. Dental Res. 2007, 86, 426-430). (ii) Mix sodium chloride (0.06 g), potassium chloride (0.072 g), calcium chloride dihydrate (0.022 g), potassium dihydrogen phosphate (0.068 g), disodium hydrogen phosphate dodecahydrate (0.086 g), potassium thiocyanate (0.006 g), sodium bicarbonate (0.15 g), and citric acid (0.003 g) in 100 mL of distilled water at pH 6.5 (see Duffo, GS; et al., Development of artificial saliva for studying the corrosion behavior of dental alloys. Corrosion 2004, 60, 594-602).

[0110] Example 16. Solidification of artificial saliva using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial saliva (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0111] Example 17. Solidification of artificial saliva using sodium silicate, acid, and alumina powder (60-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial saliva (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of alumina powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0112] Example 18. Solidification of artificial saliva using sodium silicate, acid, and titania powder (a mixture of anatase and rutile) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial saliva (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of titania powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0113] Example 19. Solidification of artificial saliva using sodium silicate, acid, and zinc oxide powder (particle size <500 μm) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial saliva (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of zinc oxide powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0114] Example 20. Preparation of artificial urine Urea (1.82 g) was added to 75 mL of distilled water in a container and shaken well to dissolve. Sodium chloride (0.75 g), potassium chloride (0.45 g), and sodium phosphate (0.48 g) were further added to the mixture and mixed well until dissolved. The pH was adjusted to between 5 and 7. Creatinine powder (200 mg) and albumin powder (5 mg) were added and gently mixed. The resulting artificial urine was further spiked with a few mg of glucose before each experiment.

[0115] Example 21. Solidification of artificial urine using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial urine (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0116] Example 22. Solidification of artificial urine using sodium silicate, acid, and alumina powder (60-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial urine (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of alumina powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0117] Example 23. Solidification of artificial urine using sodium silicate, acid, and titania powder (a mixture of anatase and rutile) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial urine (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of titania powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0118] Example 24. Preparation of artificial blood A 6% solution of BSA was prepared in distilled water. A small amount of iron(II) complex was added to the heme to impart color.

[0119] Example 25. Solidification of artificial blood using sodium silicate, acid, and silica gel powder (60-120, 100-200, or 230-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial blood (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of silica gel powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0120] Example 26. Solidification of artificial blood using sodium silicate, acid, and alumina powder (60-400 mesh) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial blood (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of alumina powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0121] Example 27. Solidification of artificial blood using sodium silicate, acid, and titania powder (a mixture of anatase and rutile) Sodium hydroxide (300 mg / mL) was added to an aqueous solution of sodium silicate (20-40%). Artificial blood (1:1) was added to the above solution and mixed thoroughly. Acetic acid was added dropwise, and instantaneous coagulation was observed. The addition of titania powder resulted in instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0122] Example 28. Immobilization of solid cotton swabs using sodium silicate, acid, and silica gel (60-400 mesh) powder, alumina (60-400 mesh) powder, titania (a mixture of anatase and rutile) powder, or zinc oxide (particle size <500 μm) powder. A cotton swab (4 cm) was immersed in an aqueous solution of sodium silicate containing sodium hydroxide (300 mg / mL) in an 8 mL glass vial. After thorough mixing, acetic acid was added dropwise to induce flocculation. Then, solid powders of silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), or zinc oxide (particle size <500 μm) were added to induce instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0123] Example 29. Immobilization of injection needles using sodium silicate, acid, and silica gel (60-400 mesh) powder, alumina (60-400 mesh) powder, titania (a mixture of anatase and rutile) powder, or zinc oxide (particle size <500 μm) powder. A needle (4-6 cm) was immersed in an aqueous solution of sodium silicate containing sodium hydroxide (300 mg / mL) in an 8 mL glass vial. After thorough mixing, acetic acid was added dropwise to induce flocculation. Then, solid powders of silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), or zinc oxide (particle size <500 μm) were added to induce instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0124] Example 30. Immobilization of cotton waste using sodium silicate, acid, and silica gel (60-400 mesh) powder, alumina (60-400 mesh) powder, titania (a mixture of anatase and rutile) powder, or zinc oxide (particle size <500 μm) powder. A piece of cotton was added to an aqueous solution of sodium silicate containing sodium hydroxide (300 mg / mL) in an 8 mL glass vial. After thorough mixing, acetic acid was added dropwise to induce flocculation. Then, solid powders of silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), or zinc oxide (particle size <500 μm) were added to induce instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0125] Example 31. Immobilization of tissue paper using sodium silicate, acid, and silica gel (60-400 mesh) powder, alumina (60-400 mesh) powder, titania (a mixture of anatase and rutile) powder, or zinc oxide (particle size <500 μm) powder. A piece of tissue paper was added to an aqueous solution of sodium silicate containing sodium hydroxide (300 mg / mL) in an 8 mL glass vial. After thorough mixing, acetic acid was added dropwise to induce flocculation. Then, solid powders of silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), or zinc oxide (particle size <500 μm) were added to induce instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0126] Example 32. Immobilization of large quantities of mixed waste using sodium silicate, acid, and silica gel (60-400 mesh) powder, alumina (60-400 mesh) powder, titania (a mixture of anatase and rutile) powder, or zinc oxide (particle size <500 μm) powder. Mixtures of different waste materials (solids and liquids – syringes, needles, cotton swabs, cotton, tissues, artificial urine, artificial blood and saliva, iodine, potassium dichromate, salts, sugars, etc.) were added to an aqueous solution of sodium silicate containing sodium hydroxide (300 mg / mL) in a glass beaker. After thorough mixing, acetic acid was added dropwise to induce flocculation. Solid powders of silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), or zinc oxide (particle size <500 μm) were then added to induce instantaneous solidification. Sulfuric acid, hydrochloric acid, or phosphoric acid were also used instead of acetic acid.

[0127] Example 33. Antimicrobial test Cultures of Escherichia coli and Staphylococcus aureus were prepared in Luria Bertiani (LB) medium, and the colony-forming units (cfus) were approximately 1–3 × 10⁶ per milliliter of E. coli or Staphylococcus aureus. 6 Samples were taken for analysis at 18 hours of the old stage (pre-standardized based on optical density at 600 nm). 1 mL of aqueous sodium silicate solution containing sodium hydroxide (300 mg / mL) was added to 1 mL of bacterial broth (spiking solution), and the bottle was rotated to mix. Samples were taken for analysis at regular time intervals. Acetic acid was then added dropwise, followed by the addition of silica gel solid powder (60-120 mesh) to induce instantaneous solidification. Samples were taken again for analysis at regular time intervals. All samples were diluted to 10 × in sterile saline, and 100 μL of the diluted solution was placed on an LB agar dish and incubated overnight at 37°C. In parallel, the original bacterial suspension was serially diluted in sterile saline, and 100 μL of the appropriate dilution was placed on an LB agar dish and incubated for the control test samples. The colonies were counted the following day based on the applied dilution, and the number of CFUs / mL in the original bacterial suspension added to the sol and the number of CFUs in the gelled disinfectant were calculated. Efficiency was calculated as follows and expressed as a percentage: [(Number of CFUs in bacterial suspension - Number of CFUs in gelled disinfectant) / Number of CFUs in bacterial suspension] × 100.

[0128] Example 34. Prototype for an all-in-one sample collection, disinfection, and disposal device for fluid samples. An all-in-one sample collection, disinfection, and disposal device for fluid samples was prototyped as follows: Four plastic collection vials were mounted with one vial on top of the others, the top vial to contain silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), zinc oxide (particle size <500 μm) solid powder, or cerium or lanthanum phosphate; the second vial to contain acetic acid, sulfuric acid, hydrochloric acid, or phosphoric acid; the third vial for sample collection; and the bottom vial pre-filled with the required amount of aqueous sodium silicate solution containing sodium hydroxide (300 mg / mL). This design allowed the top compartment to be unscrewed and the sample to be collected in the third compartment. After testing the collected sample waste, the remaining sample was disinfected by first mixing the sample with an alkaline sodium silicate solution in the bottom container by breaking the joint between the third compartment and the bottom compartment, followed by agglomeration using acid in the second compartment by breaking the joint between the second and third compartments. Solidification was brought about by adding the corresponding solid powder from the top compartment by breaking the joint between the top compartment and the second compartment. This mixture allows for complete pathogenic disinfection as shown in Example 33.

[0129] Example 35. Prototype for an all-in-one sample collection, disinfection, and disposal device for solid samples. An all-in-one sample collection-disinfection-disposal device for solid samples was prototyped as follows: A plastic collection container for solid samples (e.g., cotton waste) was mounted on top of which had two plastic vials, the top vial to contain silica gel (60-400 mesh), alumina (60-400 mesh), titania (a mixture of anatase and rutile), or zinc oxide (particle size <500 μm), the middle vial to contain acetic acid, sulfuric acid, hydrochloric acid, or phosphoric acid, and the bottom vial to be pre-filled with the required amount of aqueous sodium silicate solution containing sodium hydroxide (300 mg / mL). This design allowed the top compartment to be unscrewed so that the solid sample could be collected in the bottom compartment. Once the solid sample was collected in the bottom container, it was disinfected and agglutinated by breaking the joint between the middle and bottom compartments, thereby allowing the alkaline sample in the bottom compartment to mix with the corresponding acid. The addition of solid powder by breaking the junction between the top and middle compartments resulted in solidification. This mixture enables complete pathogenic disinfection, as demonstrated in Example 33.

[0130] Advantages of the present invention This invention provides a method for disinfection followed by in-situ agglutination and solidification using a disinfection-aggregation-solidification and disposal system that exhibits unique antimicrobial activity. The method of this invention is an instantaneous method of disinfection and solidification upon mixing. The method also provides a microbial disinfection rate of over 99.9% within one minute. The method of this invention provides the possibility of stopping in the agglutinated state of the in-situ for easy recovery and recycling. Furthermore, the method of this invention reduces the risk of overflow and occupational exposure. In addition, the method of this invention allows the waste to be disposed of as non-standard medical waste. The provided method of this invention is applicable to both the decontamination of fluid medical waste and the decontamination of solid medical waste. Due to the use of precursor materials, the method of this invention is safer, easier, more cost-effective, and applicable to the management of any amount of fluid waste. In addition, this invention provides an uninterrupted and intermediary-free method from proteins, metal ions, salts, or other impurities. Furthermore, the present invention encompasses the following aspects. 1. A method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system, wherein the disinfection composition comprises four chemical components A, B, C, and D. (a) A is an alkali metal silicate selected from the group consisting of sodium, potassium, and combinations thereof in a 20-40% aqueous solution of the same substance with a concentration of 0.5-80% (w / v). (b) B is a base with a concentration of 0.1-90% w / v that is added to the aqueous solution of A. (c) C is an organic or inorganic acid that is completely miscible with water. (d) D is a solidifying agent selected from oxide or phosphate powders, particularly oxides / phosphates of elements such as silicon, titanium, zinc, aluminum, or lanthanides, e.g., cerium or lanthanum. method. 2. B, the base, in solution A 、0 0.1~5g / mL AA method for disinfection and subsequent agglomeration and solidification of an in situ as described in item 1, comprising sodium hydroxide or potassium hydroxide, alkali metal or alkaline earth metal hydroxide selected from the group consisting of basic salts of metals and organic cations, which, when added within the range, leads to a final pH in the range of 9 to 14. 3. The method of disinfection and subsequent agglomeration and solidification of an in situ according to item 1, wherein C is an organic or inorganic acid having the general formula HnX (wherein X is selected from the group consisting of anions, particularly halide ions, acetate ions, sulfate ions and phosphate ions, and n is an integer such that 1 ≤ n ≤ 3). 4. The method for agglomeration and solidification of an in situ following disinfection as described in item 1, wherein the solidifying agent is selected from chromatographic-grade silica gel powder of 60-400 mesh size, chromatographic-grade alumina powder of 60-200 mesh size, pigment-grade titania in rutile form or anatase form or a mixture of rutile form and anatase form, industrial-grade zinc oxide in powder form having a particle size of less than 500 μm, or lanthanum phosphate or cerium phosphate as nanopowder, with or without a binder. 5. A disinfection-aggregation-solidification method described in any one of paragraphs 1 to 4, (a) The step of adding B to an aqueous solution of A, (b) A step of adding the biological medical waste to be disinfected to the aqueous solution prepared in step (a), (c) A step of homogenizing a mixture as described in (b) and / or letting it stand for 10 to 30 minutes, characterized in that the resulting mixture is aggregated. (d) A step of adding material C and material D as solid powders, followed by mixing and / or standing, wherein the resulting mixture is solidified. including, method. 6. The disinfection-coagulation-solidification method according to item 5, wherein the amount of waste added is less than 1:1000 (v / v) of solution B for liquid waste and is any submersible amount of solid waste or a mixture thereof. 7. The disinfection-aggregation-solidification method according to item 5, wherein C is glacial acetic acid, and the amount of C added is 0.1 to 3 mL per 1 mL of all aqueous mixture obtained in step (b). 8. The disinfection-coagulation-solidification method according to item 5, wherein solid A is added in an amount of a minimum of 1% (w / v) and a maximum of 500% (w / v) of the total aqueous volume in the mixture obtained in step (c). 9. The disinfection-aggregation-solidification method according to item 5, wherein the biomedical waste samples used in step (b) are selected from the group consisting of salts, sugars, metal salts and complexes, aqueous waste, hospital chemicals, e.g., iodine, saliva, urine, blood, or any solid sample, in particular cotton, tissue paper, needles, syringes or cotton swabs, and disinfection is carried out by a high pH solution A containing B. 10. A disinfection-coagulation-solidification method according to any one of sections 5 to 9, which assists either coagulation resulting in a soft aggregated solid when completed in step (c) of section 5, or solidification resulting in a hard solid when proceeding to step (d) of section 5. 11. A disinfection-aggregation-solidification and disposal device filled with a disinfection composition containing the four chemical components described in item 1, (a) Upper container or compartment system [Figure 33, 1], (b) Second container or compartment system [Figure 33, 2], (c) Third container or compartment system [Figure 33, 3] (d) Bottom container or compartment system [Figures 33, 4] (e) Screw caps connected to the upper container or compartment system [Figures 33, 5] and (f) Three breakable screw caps [Figure 33, 6], one cap connecting the upper container or compartment system to the second container or compartment system, another cap connecting the second container or compartment system to the third container or compartment system, and the third cap connecting the third container or compartment system to the bottom container or compartment system. Disinfection-aggregation-solidification and disposal devices, including those mentioned above. 12. The disinfection-coagulation-solidification and disposal system according to item 11, wherein the upper container or compartment system is filled with the solid powder of material D. 13. The disinfection-coagulation-solidification and disposal system according to item 11, wherein the second container or compartment system is filled with solution C. 14. The disinfection-aggregation-solidification and disposal system described in paragraph 11, wherein a third container or compartment system is filled with a biomedical waste sample. 15. The disinfection-coagulation-solidification and disposal system according to item 11, wherein the bottom container or compartment system is filled with an aqueous solution of A mixed with B as described in item 5. 16. A disinfection-solidification and disposal system according to any one of sections 11 to 15, wherein the biomedical sample is solid or liquid waste or a mixture thereof.

Claims

1. A method for disinfection and subsequent agglomeration and solidification of an in situ using a disinfection-aggregation-solidification and disposal system, wherein the disinfection composition comprises four chemical components A, B, C, and D. (a) A is an alkali metal silicate selected from the group consisting of sodium, potassium, and combinations thereof in an aqueous solution of the same concentration of 0.5 to 80% (w / v), (b) B is a base with a concentration of 0.1 to 90% w / v that is added to the aqueous solution of A. (c) C is an organic or inorganic acid that is completely miscible with water. (d) D is a solidifying agent selected from oxide or phosphate powders, particularly oxides / phosphates of elements silicon, titanium, zinc, aluminum, or lanthanides. (a) The step of adding B to an aqueous solution of A, (b) A step of adding the biological medical waste to be disinfected to the aqueous solution prepared in step (a), (c) A step of homogeneously mixing a mixture as described in (b), characterized in that the resulting mixture is aggregated. (d) A step of adding material C and material D as solid powders and subsequently mixing them, characterized in that the resulting mixture is solidified. This process includes the following four steps in sequence: method.

2. The method of disinfection followed by aggregation and solidification of an in situ according to claim 1, wherein the element of the lanthanide is cerium or lanthanum.

3. The method for disinfection and subsequent aggregation and solidification of an in situ according to Claim 1, wherein base B is selected from the group consisting of hydroxides of alkali metals or alkaline earth metals selected from the group consisting of sodium hydroxide or potassium hydroxide, basic salts of metals, and organic cations, and 0.1 to 5 g of B is added per 1 mL of a 0.5 to 80% (w / v) aqueous solution of A.

4. C is, General formula H ｎ The method for disinfection and subsequent aggregation and solidification of an in situ according to claim 1, wherein X is an organic or inorganic acid having X (wherein X is selected from the group consisting of anions, particularly halide ions, acetate ions, sulfate ions and phosphate ions, and n is an integer such that 1 ≤ n ≤ 3).

5. A method for disinfecting and subsequently agglomerating and solidifying an in situ according to claim 1, wherein the solidifying agent is selected from, with or without a binder, chromatography-grade silica gel powder of 60 to 400 mesh size, chromatography-grade alumina powder of 60 to 200 mesh size, pigment-grade titania in rutile form or anatase form or a mixture of rutile form and anatase form, industrial-grade zinc oxide in powder form having a particle size of less than 500 μm, or lanthanum phosphate or cerium phosphate as nanopowder.

6. The disinfection-coagulation-solidification method according to claim 1, wherein the amount of waste added is less than 1:1000 (v / v) of solution B for liquid waste and is any submersible amount of solid waste or a mixture thereof.

7. The disinfection-aggregation-solidification method according to claim 1, wherein C is glacial acetic acid, and the amount of C added is 0.1 to 3 mL per 1 mL of all aqueous mixture obtained in step (b).

8. The disinfection-coagulation-solidification method according to claim 5, wherein solid A is added in a minimum of 1% (w / v) and a maximum of 500% (w / v) of the total aqueous volume in the mixture obtained in step (c).

9. The disinfection-aggregation-solidification method according to claim 1, wherein the biomedical waste samples used in step (b) are selected, either alone or in combination, from the group consisting of salts, sugars, metal salts and complexes, aqueous waste, and hospital chemicals, and disinfection is carried out by the high pH of solution A containing B.

10. The disinfection-aggregation-solidification method according to claim 9, wherein the salt, sugar, metal salt and complex, aqueous waste, hospital chemical is iodine, saliva, urine, blood; or any solid sample, in particular cotton, tissue paper, needle, syringe or cotton swab.

11. The disinfection-aggregation-solidification method according to claim 1, wherein the process ends in either agglutination resulting in a soft aggregated solid when completed in step (c) of claim 1, or solidification resulting in a hard solid when proceeding to step (d) of claim 1.

12. A disinfection-aggregation-solidification and disposal device filled with a disinfection composition containing four chemical components as described in claim 1, (a) Upper container or compartment system, (b) Second container or compartment system, (c) A third container or compartment system, (d) Bottom container or compartment system, (e) Screw caps connected to the upper container or compartment system and (f) Three breakable screw caps, one cap connecting the upper container or compartment system to the second container or compartment system, another cap connecting the second container or compartment system to the third container or compartment system, and the third cap connecting the third container or compartment system to the bottom container or compartment system. Including, here, The upper container or compartment system (a) is filled with solid powder of material D, the second container or compartment system (b) is filled with solution C, the third container or compartment system (c) is filled with a biomedical waste sample, and the bottom container or compartment system (d) is filled with an aqueous solution of A mixed with B as described in claim 1. Disinfection-aggregation-solidification and disposal device.

13. The disinfection-solidification and disposal system according to claim 12, wherein the biomedical sample is solid or liquid waste or a mixture thereof.

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