Support for adhesive patches and adhesive patches

Abstract

To provide a patch support body and a patch, which have an excellent sticking feeling.SOLUTION: The patch support body of the present invention has a thin thickness of less than 100 μm excluding a polyester film of the patch support body. The patch does not give a sense of discomfort when it is applied to the skin, does not easily come off by rubbing of clothes or the like, and has an excellent sticking feeling. A polyester fiber non-woven fabric is mainly composed of polyester fibers having an average fiber length of more than 15 mm and thus the polyester fibers are less likely to fall off due to a large number of adhesion points between the polyester fibers and the good entanglement of the fibers. Further, even if a pressure-sensitive adhesive applied to the patch is hard, the polyester fiber non-woven fabric is not easily destroyed by the pressure-sensitive adhesive.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a patch having an adhesive containing various pharmacoactive ingredients, and a support capable of supporting the adhesive. [Background technology]

[0002] Patches, which are applied to the human body to achieve various effects such as anti-inflammatory and analgesic properties, and which consist of an adhesive containing a medicinal ingredient coated onto a support, are widely known as poultices, plasters, or therapeutic adhesive tapes. In this invention, these are collectively referred to as "patches," and various medicinal ingredients are known for such patches, depending on the expected effect. These adhesives containing medicinal ingredients are coated onto a support such as a nonwoven fabric, resin film, or a composite thereof.

[0003] As a support for use in such adhesive patches, the applicant proposed "a support for adhesive patches in which a polyester film and a polyester fiber nonwoven fabric are bonded by deformation of the undrawn polyester fibers of a fiber web containing undrawn polyester fibers, characterized in that the thickness of the support for adhesive patches excluding the polyester film is 100 μm or more" (Patent Document 1). [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Patent Publication No. 2016-88855 [Overview of the project] [Problems that the invention aims to solve]

[0005] However, the adhesive sheet using the support for adhesive sheet of Patent Document 1 is thick with a thickness of 100 μm or more excluding the polyester film among the supports for adhesive sheet. Therefore, when the adhesive sheet is attached to the skin, it is easy to feel a sense of discomfort such as tightness, and also the adhesive sheet is likely to peel off due to rubbing against clothes or the like, resulting in poor adhesion feeling.

[0006] The present invention has been made under such circumstances, and an object thereof is to provide a support for adhesive sheet and an adhesive sheet having excellent adhesion feeling.

Means for Solving the Problems

[0007] The invention according to claim 1 of the present invention is "a support for adhesive sheet in which a polyester film and a polyester fiber nonwoven fabric mainly composed of polyester fibers having an average fiber length exceeding 15 mm are adhered by deformation of undrawn polyester fibers in a fiber web containing undrawn polyester fibers, and the thickness of the support for adhesive sheet excluding the polyester film is less than 100 μm, a support for adhesive sheet."

[0008] The invention according to claim 2 of the present invention is "the support for adhesive sheet according to claim 1, wherein the polyester fibers having an average fiber length exceeding 15 mm contained in the polyester fiber nonwoven fabric are 70 mass% or more."

[0009] The invention according to claim 3 of the present invention is "the support for adhesive sheet according to claim 1 or 2, wherein the average value of the bending rigidity in the longitudinal direction and the lateral direction by the KES method is 0.050 cN·cm 2 / cm or less."

[0010] The invention according to claim 4 of the present invention is "the support for adhesive sheet according to any one of claims 1 to 3, wherein each of the polyester film, the polyester fiber nonwoven fabric, and the fiber web containing undrawn polyester fibers is composed of polyethylene terephthalate."

[0011] The invention according to claim 5 of the present invention is "an adhesive patch comprising an adhesive on the polyester fiber nonwoven fabric side of the support for the adhesive patch described in any one of claims 1 to 4." [Effects of the Invention]

[0012] The adhesive support according to claim 1 of the present invention is thin, with a thickness of less than 100 μm excluding the polyester film, so that when the adhesive is applied to the skin, it is less likely to cause discomfort, and the adhesive is less likely to peel off due to friction with clothing, etc., resulting in a superior adhesive feel. Furthermore, since the polyester fiber nonwoven fabric mainly consists of polyester fibers with an average fiber length of more than 15 mm, there are many adhesion points between the polyester fibers, and the fibers intertwine well, making it less likely for the polyester fibers to fall off, and even if the adhesive applied to the adhesive is hard, the polyester fiber nonwoven fabric is less likely to be damaged by the adhesive.

[0013] The support for adhesive patches according to claim 2 of the present invention contains polyester fiber nonwoven fabric in which 70 mass% or more of polyester fibers have an average fiber length of 15 mm or more. As a result, there are many bonding points between the polyester fibers, and the fibers intertwine well, making it less likely for the polyester fibers to fall off. Furthermore, even if the adhesive applied to the patch is hard, the polyester fiber nonwoven fabric is less likely to be damaged by the adhesive.

[0014] The adhesive support according to claim 3 of the present invention has a low bending rigidity value and is easy to bend for application. Because it is a support material for the patch, it is less likely to cause discomfort when applied to the skin, resulting in a superior feeling of adhesion.

[0015] The support for adhesive according to claim 4 of the present invention is a polyester film, polyester fiber Both nonwoven fiber fabrics and fiber webs containing undrawn polyester fibers are made of polyethylene terephthalate. Because it is composed of a sulfate, the support material for the patch does not easily adsorb the active ingredient.

[0016] The adhesive patch according to claim 5 of the present invention has an adhesive on the polyester fiber nonwoven fabric side of the support, so the adhesive is held in place by the polyester nonwoven fabric due to the anchoring effect and is less likely to leak out. In addition, because it is thin, it is less likely to cause discomfort when the patch is applied to the skin, and the patch is less likely to peel off due to friction with clothing, etc., resulting in a superior adhesive feel. Furthermore, the average fiber length of the polyester fibers constituting the polyester fiber nonwoven fabric is long, at 15 mm or more, and there are many adhesion points between the polyester fibers and the fibers intertwine well, so the polyester fiber nonwoven fabric does not delaminate between layers, and therefore when the patch is peeled off after use, the adhesive is less likely to remain on the skin. [Modes for carrying out the invention]

[0017] The adhesive support of the present invention (hereinafter sometimes simply referred to as "support") is formed by bonding a polyester film and a polyester fiber nonwoven fabric with an average fiber length of 15 mm or more, through the deformation of the undrawn polyester fibers in a fiber web containing undrawn polyester fibers.

[0018] The polyester film prevents the penetration of the adhesive, assists in the full action of the active ingredient, prevents adhesion to the user's clothing, and prevents the volatilization of the active ingredient. For such a polyester film, it is preferable that it is at least a uniaxially stretched polyester film, considering its adhesion to the unstretched polyester fibers described later.

[0019] The polyester constituting such a film is preferably non-elastomer. This is because a non-elastomer does not contain soft segments like elastomers, and the polyester film itself is less likely to adsorb active pharmaceutical ingredients. Thus, "non-elastomer" means that it is not a polyether ester block copolymer formed by copolymerizing poly(alkylene oxide) glycol or the like as soft segments.

[0020] Specifically, polyesters having aromatic dicarboxylic acids as the main acid component and alkylene glycols as the main glycol component are non-elastomers. For example, aromatic dicarboxylic acids include terephthalic acid, isophthalic acid, naphthalenedicarboxylic acid, diphenoxyethanedicarboxylic acid, diphenyldicarboxylic acid, diphenyl etherdicarboxylic acid, diphenylsulfonedicarboxylic acid, and diphenylketonedicarboxylic acid. Alkylene glycols include ethylene glycol, trimethylene glycol, tetramethylene glycol, pentamethylene glycol, hexamethylene glycol, and hexylene glycol. More specifically, polybutylene terephthalate, polytrimethylene terephthalate, or polyethylene terephthalate are preferred. These polyester films do not readily adsorb active pharmaceutical ingredients, thus allowing them to fully exert their medicinal effects. Polyethylene terephthalate film is particularly preferred because it is extremely resistant to adsorption of active pharmaceutical ingredients and can maintain its dimensions even when bonded by deformation of undrawn polyester fibers, as described later.

[0021] Furthermore, polyester films may be embossed, sandblasted, printed, or colored with inorganic and / or organic fine particles, dyes, or pigments for purposes such as enhancing their design, indicating their effectiveness, and / or improving their opacity. Also, polyester films do not need to be single-layer products; they may be laminated products.

[0022] The support of the present invention includes a polyester fiber nonwoven fabric in addition to the polyester film described above, and can hold the adhesive by an anchoring effect, so that the adhesive does not remain on the skin when the adhesive is peeled off.

[0023] This polyester fiber nonwoven fabric mainly consists of polyester fibers with an average fiber length exceeding 15 mm. In other words, 50 mass% or more of the polyester fibers in the polyester fiber nonwoven fabric have an average fiber length exceeding 15 mm. As a result, there are many bonding points between the polyester fibers, and the fibers intertwine well, making it difficult for the polyester fibers to fall off. Furthermore, due to the deformation of the undrawn polyester fibers described later, it can adhere firmly to the polyester film and is difficult to peel off from the polyester film. In this invention, when simply referred to as "polyester fiber," it means "drawn polyester fiber," and "drawn polyester fiber" refers to a fiber that has undergone mechanical drawing after being spun. When referring to undrawn polyester fibers that have not undergone mechanical drawing after spinning, it is referred to as "undrawn polyester fiber." The amount of polyester fibers contained in the polyester fiber nonwoven fabric with an average fiber length exceeding 15 mm is more preferably 70 mass% or more, even more preferably 75 mass% or more, and even more preferably 80 mass% or more.

[0024] The polyester resin constituting this polyester fiber can be the same polyester resin as that used for the polyester film mentioned above. Specifically, it can consist of an aromatic dicarboxylic acid as the main acid component and an alkylene glycol as the main glycol component. More specifically, examples of aromatic dicarboxylic acids include terephthalic acid, isophthalic acid, naphthalenedicarboxylic acid, diphenoxyethanedicarboxylic acid, diphenyldicarboxylic acid, diphenyl etherdicarboxylic acid, diphenylsulfonedicarboxylic acid, and diphenylketonedicarboxylic acid. Examples of alkylene glycols include ethylene glycol, trimethylene glycol, tetramethylene glycol, pentamethylene glycol, hexamethylene glycol, and hexylene glycol. Polyethylene terephthalate, polybutylene terephthalate, and polytrimethylene phthalate are particularly suitable because they do not readily adsorb active pharmaceutical ingredients and allow the active ingredients to exert their full effect. Among these, polyethylene terephthalate is especially suitable because it is extremely reluctant to adsorb active pharmaceutical ingredients. The polyester fiber may also contain additives such as antistatic agents, antioxidants, and UV absorbers.

[0025] This polyester fiber may be a single-component fiber made from one type of polyester resin, as described above, but it can also be a composite fiber made by combining two or more types of polyester resins. Furthermore, because the polyester fiber nonwoven fabric itself is flexible, the support material is flexible and easy to bend, resulting in less discomfort when using the adhesive.

[0026] Furthermore, the polyester fiber nonwoven fabric may contain, as a fiber other than polyester fibers, for example, undrawn polyester fibers; polyamide fibers such as nylon 6 and nylon 66; polyolefin fibers such as polypropylene and polyethylene; acrylic fibers such as polyacrylonitrile; and / or polyvinyl alcohol fibers. Among these, it is preferable to include undrawn polyester fibers because they have good adhesion to the fiber web described later. However, in order for the polyester fiber nonwoven fabric to adhere firmly to the polyester film, for the polyester fiber nonwoven fabric to be difficult to peel off from the polyester film, and for a support that is soft and has excellent adhesion properties, it is preferable that the amount of fibers other than polyester fibers contained in the polyester fiber nonwoven fabric be 50 masss% or less, more preferably 40 masss% or less, even more preferably 30 masss% or less, and still more preferably 20 masss% or less.

[0027] The fibers constituting the polyester fiber nonwoven fabric of the present invention may be white, but they may also be colored with pigments and / or dyed with dyes. For example, if the polyester fiber nonwoven fabric is colored to a skin tone, it is preferable because it will not be noticeable when applied to the skin.

[0028] The average fiber length of the polyester fibers contained in the polyester fiber nonwoven fabric exceeds 15 mm. This is because an average fiber length exceeding 15 mm results in more bonding points between polyester fibers, and the fibers intertwine well, making it less likely for polyester fibers to fall off. Furthermore, even if the adhesive applied to the adhesive is hard, the polyester fiber nonwoven fabric is less likely to be damaged by the adhesive. The longer the average fiber length of the polyester fibers, the greater these effects are obtained, so 25 mm or more is more preferable, and 35 mm or more is even more preferable. There is no particular upper limit to the average fiber length, but from the point of fiber opening during the manufacture of the polyester fiber nonwoven fabric, it is preferable to be 100 mm or less. In this invention, "fiber length" refers to the measured value specified as the direct method (Method C) in JIS L 1015 "Test Method for Chemical Fiber Staples," 8.4.1, and the average fiber length refers to the average of the fiber lengths of 50 fibers.

[0029] The polyester fiber nonwoven fabric of the present invention may contain two or more types of fibers (especially polyester fibers) with different fiber lengths. When it contains two or more types of fibers with different fiber lengths, it is preferable that the average fiber length (L) calculated from the following relational formula falls within the range of the fiber lengths, and it is more preferable that the fiber lengths of all the fibers contained in the polyester fiber nonwoven fabric exceed 15 mm.

[0030] (Relationship) When the fiber lengths of each fiber contained in a polyester fiber nonwoven fabric are a(mm), b(mm), c(mm)..., and the content ratios of each fiber in the polyester fiber nonwoven fabric are a'(mass%), b'(mass%), c'(mass%)..., respectively, the following relationship holds. (a´ / a)+(b´ / b)+(c´ / c)···=(100 / L)

[0031] Furthermore, the fineness of the fibers (especially the polyester fibers) constituting such a polyester fiber nonwoven fabric is preferably 4.0 dtex or less, more preferably 3.0 dtex or less, and even more preferably 2.0 dtex or less, so that the fibers intertwine easily and the polyester fiber nonwoven fabric has excellent texture. On the other hand, if the fineness is too low, the fibers tend to intertwine too strongly, resulting in poor flexibility, so it is preferably 0.50 dtex or more, and more preferably 0.75 dtex or more.

[0032] The polyester fiber nonwoven fabric of the present invention may contain two or more types of fibers (especially polyester fibers) with different finenesses, but when it contains two or more types of fibers with different finenesses, it is preferable that the average fineness (D) calculated from the following relational formula falls within the range of the average fineness.

[0033] (Relationship) When the fineness of each fiber contained in the polyester fiber nonwoven fabric is x(dtex), y(dtex), z(dtex)..., and the content ratio of each fiber in the polyester fiber nonwoven fabric is x'(mass%), y'(mass%), z'(mass%)..., the following relationship holds. (x´ / x)+(y´ / y)+(z´ / z)···=(100 / D)

[0034] The polyester fiber nonwoven fabric of the present invention can be manufactured, for example, by forming a fiber structure mainly composed of polyester fibers and then bonding them together. Examples of methods for forming the fiber structure include dry methods such as the carding method and the air-laying method, wet methods, or direct methods such as the spunbonding method. These fiber structures can also be laminated. Furthermore, the orientation direction of the fibers constituting the fiber structure is not particularly limited, and can be, for example, a parallel web oriented in one direction, a cross web in which parallel webs are oriented transversely by a cross-layer, a crisscross web formed by laminating a parallel web and a cross web, a random web, or a triascross web formed by laminating one cross-lay web and two parallel or random webs.

[0035] The method of joining these fibrous structures is not particularly limited, but examples include joining them with a liquid binder or adhesive fibers, or joining them by entanglement using a fluid flow such as water or needles.

[0036] While there are no particular limitations on the basis weight of polyester fiber nonwoven fabrics, which primarily consist of polyester fibers with an average fiber length exceeding 15 mm, the basis weight should be between 3 and 25 g / m² to avoid discomfort when using adhesive patches. 2 Preferably, it is 4-20 g / m 2 It is more preferable that it be 5-15 g / m 2 It is even more preferable that this is the case. In this invention, "basis weight" is 1m 2 This is the mass per unit area, and is a value obtained by the method specified in JIS L 1913:2010-6.2 (mass per unit area).

[0037] The support of the present invention comprises a polyester film and a polyester fiber nonwoven fabric as described above, which are bonded together by the deformation of the undrawn polyester fibers in the fiber web containing the undrawn polyester fibers. In this way, the polyester film and the polyester fiber nonwoven fabric are not bonded together by an adhesive, but by the deformation of the undrawn polyester fibers, so adsorption of medicinal components and discoloration are less likely to occur, and the efficacy of the medicinal components is easily exerted. Furthermore, the adhesive strength of the undrawn polyester fibers is not reduced by the influence of adhesives or medicinal components, and peeling of the polyester film and polyester fiber nonwoven fabric is less likely to occur, so even if the patch is peeled off, the adhesive is less likely to remain on the skin.

[0038] Although these undrawn polyester fibers are made of polyester resin, just like polyester films and polyester fiber nonwovens, they have not undergone mechanical stretching after spinning. Therefore, they can be plastically deformed by pressurization and heating, allowing them to firmly bond with polyester films and polyester fiber nonwovens, making them less prone to peeling.

[0039] As long as these undrawn polyester fibers remain undrawn, they can be made from the same polyester resin as polyester fibers that can form polyester fiber nonwovens. In other words, aromatic dicarboxylic acids can be the main acid component, and alkylene glycols can be the main glycol component. Specifically, examples of aromatic dicarboxylic acids include terephthalic acid, isophthalic acid, naphthalenedicarboxylic acid, diphenoxyethanedicarboxylic acid, diphenyldicarboxylic acid, diphenyl etherdicarboxylic acid, diphenylsulfonedicarboxylic acid, and diphenylketonedicarboxylic acid. Examples of alkylene glycols include ethylene glycol, trimethylene glycol, tetramethylene glycol, pentamethylene glycol, hexamethylene glycol, and hexylene glycol. Polyethylene terephthalate, polybutylene terephthalate, and polytrimethylene phthalate are particularly suitable because they have low adsorption of active pharmaceutical ingredients. Polyethylene terephthalate fibers are particularly suitable because they have extremely low adsorption of active pharmaceutical ingredients. Undrawn polyester fibers may also contain additives such as antistatic agents, antioxidants, and UV absorbers.

[0040] The undrawn polyester fiber of the present invention may be an undrawn polyester fiber made of one type of polyester resin as described above, or it may be an undrawn polyester composite fiber made of two or more types of polyester resins. In such an undrawn polyester composite fiber, the arrangement of resins in the fiber cross-section can be, for example, core-sheath type, side-by-side type, orange type, or sea-island type.

[0041] The fineness of the undrawn polyester fiber is not particularly limited, but to ensure stronger adhesion, it is preferably 1.0 dtex or more, more preferably 2.0 dtex or more, and even more preferably 3.0 dtex or more. On the other hand, if it is too thick, sufficient adhesive strength may not be obtained, so it is preferably 10.0 dtex or less, more preferably 8.0 dtex or less, and even more preferably 6.0 dtex or less.

[0042] As described later, the fiber web may contain fibers other than undrawn polyester fibers, and may contain two or more types of fibers with different finenesses. However, if it contains two or more types of fibers with different finenesses, it is preferable that the average fineness, calculated in the same manner as for polyester fiber nonwoven fabrics, falls within the range of the aforementioned finenesses.

[0043] The fiber length of the fibers constituting such a fiber web is preferably 20 mm or more, more preferably 25 mm or more, and even more preferably 30 mm or more, in order to have excellent adhesive strength and uniform texture. There is no particular upper limit to the fiber length, but it is preferable that it be 100 mm or less from the viewpoint of fiber opening during fiber web manufacturing.

[0044] As described later, the fiber web may contain fibers other than undrawn polyester fibers, and may contain two or more types of fibers with different fiber lengths. However, if it contains two or more types of fibers with different fiber lengths, it is preferable that the average fiber length, as defined in the same way as for polyester fiber nonwoven fabrics, is within the range of the aforementioned fiber lengths.

[0045] The fiber web of the present invention contains undrawn polyester fibers as described above. In order to firmly bond the polyester film and the polyester fiber nonwoven fabric and prevent the polyester film and the polyester fiber nonwoven fabric from peeling off, the amount of undrawn polyester fibers in the fiber web is preferably 15 mass% or more, more preferably 17 mass% or more, and even more preferably 20 mass% or more. On the other hand, if the amount of undrawn polyester fibers is too high, the support becomes hard and tends to cause discomfort when using the adhesive. Therefore, it is preferable that the amount is 45 mass% or less, more preferably 43 mass% or less, and even more preferably 40 mass% or less. Furthermore, since a large amount of undrawn polyester fibers in the entire support may cause the support to become hard, it is preferable that the mass ratio of undrawn polyester fibers in the entire fiber web is greater than the mass ratio of undrawn polyester fibers in the entire polyester fiber nonwoven fabric.

[0046] Furthermore, the fibers other than the undrawn polyester fibers that make up the fiber web can be the same fibers that can make up polyester fiber nonwoven fabric. In other words, it can include drawn polyester fibers (especially polyethylene terephthalate fibers, polybutylene terephthalate fibers, and polytrimethylene phthalate fibers); polyamide fibers such as nylon 6 and nylon 66; polyolefin fibers such as polypropylene and polyethylene; acrylic fibers such as polyacrylonitrile; and polyvinyl alcohol fibers. Among these, drawn polyester fibers (especially polyethylene terephthalate fibers, polybutylene terephthalate fibers, and polytrimethylene phthalate fibers) are preferred because they do not easily adsorb the active ingredient and can fully exert their medicinal effect.

[0047] The fibers constituting such a fiber web may be white, as with the polyester fiber nonwoven fabric described above, or they may be colored with pigments and / or dyes.

[0048] As long as the fiber web contains undrawn polyester fibers, the manufacturing method thereof is not particularly limited. For example, it can be formed by dry methods such as the carding method and the air-laying method; wet methods; direct methods such as the melt blowing method. Among these, according to the dry method, undrawn polyester fibers and other fibers (especially drawn polyester fibers) can be uniformly mixed at an arbitrary ratio, and by adhering with undrawn polyester fibers, it is possible to alleviate the hardening of the support, so it is preferable.

[0049] Also, the basis weight of the fiber web is not particularly limited, but in order to firmly adhere the polyester film and the polyester fiber non-woven fabric, it is preferably 3.0 g / m 2 or more, more preferably 4.0 g / m 2 or more, and even more preferably 5.0 g / m 2 or more. On the other hand, if the basis weight of the fiber web is too high, the support becomes hard and there is a tendency to feel discomfort when using the adhesive, so it is preferably 10.0 g / m 2 or less, more preferably 9.0 g / m 2 or less, and even more preferably 8.0 g / m 2 or less.

[0050] The undrawn polyester fibers of such a fiber web are deformed to adhere the polyester film and the polyester fiber non-woven fabric. This adhesion can be achieved, for example, by heating and pressing the polyester film and the polyester fiber non-woven fabric in a laminated state through a fiber web containing undrawn polyester fibers to deform and adhere the undrawn polyester fibers. These heat and pressure conditions vary depending on the undrawn polyester fibers and can be set appropriately experimentally. For example, when using suitable undrawn polyethylene terephthalate fibers, the heat-adhesive temperature is about 180°C, so it can be heated at 190~230°C and pressed at a linear pressure of 150~500 N / cm. Note that heating and pressing may be simultaneous or pressing may be performed after heating.

[0051] The support of the present invention is formed by bonding a polyester film and a polyester fiber nonwoven fabric by the deformation of undrawn polyester fibers in a fiber web containing undrawn polyester fibers. However, the thickness of the support excluding the polyester film is thin, less than 100 μm, so that when the patch is applied to the skin, it is less likely to cause discomfort, and the patch is less likely to peel off due to friction with clothing, etc., resulting in a superior adhesive feel. The thinner the thickness of the support excluding the polyester film, the less discomfort is felt when the patch is applied to the skin, so it is more preferable that it be 90 μm or less, and even more preferable that it be 70 μm or less. On the other hand, if the thickness of the support excluding the polyester film is too thin, the layer containing fibers that can participate in holding the adhesive containing the active ingredient (the layer of polyester fiber nonwoven fabric and the layer derived from the fiber web) will be thin, and there is a risk that the adhesive cannot be sufficiently held by the fibers, so it is preferable that it be 15 μm or more, and more preferable that it be 25 μm or more. The thickness of the support excluding the polyester film is measured using a compression elasticity tester over a contact area of ​​5 cm². 2 This refers to the thickness obtained by measuring the thickness of the support under a load of 0.98 N {100 gf} and subtracting the thickness of the polyester film from this measured thickness.

[0052] The thickness of the polyester film is not particularly limited, but it is preferably 16 μm or less, more preferably 14 μm or less, and even more preferably 12 μm or less, in order to minimize discomfort when applied to the skin. On the other hand, the lower limit of the polyester film thickness is preferably 2.0 μm or more, in order to ensure good handling during support manufacturing and when using the adhesive patch. The thickness of the polyester film is the arithmetic mean of the thickness measured at 10 points based on electron microscope images of the cross-section in the thickness direction of the support.

[0053] Furthermore, in the layer containing the aforementioned fibers, the region bonded with undrawn polyester fibers of the fiber web is preferable because the undrawn polyester fibers are deformed, resulting in fewer voids and less involvement in adhesive retention. Therefore, the thickness of the layer derived from the fiber web is preferably 30 μm or less, more preferably 25 μm or less, and even more preferably 20 μm or less. Alternatively, the thickness of the polyester fiber nonwoven fabric layer is preferably 20 μm or more, more preferably 25 μm or more, and even more preferably 30 μm or more. This "thickness of the layer derived from the fiber web" or "thickness of the polyester fiber nonwoven fabric layer" refers to the arithmetic mean of the thickness at 10 points measured based on electron microscope images of the cross-section in the thickness direction of the support.

[0054] In the fiber-containing layer of the support of the present invention, if the voids in the fiber-containing layer are small and there are few voids that can hold the adhesive, the adhesive cannot be held sufficiently and tends to flow out. Therefore, the apparent density of the fiber-containing layer is 1.0 g / cm³. 3 Preferably, it is 0.75 g / cm³. 3 It is more preferable that it be less than 0.50 g / cm³ 3 The following is even more preferable. On the other hand, if the apparent density is too low, the amount of fiber is small and it tends to be difficult to retain the adhesive, and when the adhesive is peeled off, interlayer delamination may occur within the polyester fiber nonwoven fabric, therefore 0.15 g / cm³ is preferable. 3 Preferably, it is 0.20 g / cm³ or more. 3 The above is more preferable. The apparent density of the layer containing these fibers (unit: g / cm³) 3 ) is the basis weight (unit: g / m²) of the fiber-containing layer. 2 This value is obtained by dividing the weight (=M, unit: g / m²) by the thickness of the fiber-containing layer (unit: μm). Note that the weight of the fiber-containing layer is the value obtained by subtracting the weight of the film from the weight of the support. The weight of this film (=M, unit: g / m²) 2 ) is 1m which can be calculated from the thickness of the film. 2 Volume per unit area (=Vu, unit: cm³) 3 / m 2 ) and the specific gravity of polyester film (=SG, unit: g / cm³) 3It can be calculated by multiplying by ). In other words, it can be calculated from the following formula. M=Vu×SG

[0055] The support of this invention is easily bendable and minimizes discomfort when using adhesives, with an average bending stiffness of 0.050 cN·cm in the longitudinal and transverse directions, measured by the KES method. 2 Preferably, it should be less than or equal to / cm, and 0.045 cN·cm 2 It is more preferable that it be less than or equal to / cm, and 0.040 cN·cm 2 It is even more preferable that the average bending stiffness is less than or equal to / cm. Note that the smaller the average value of this bending stiffness, the less discomfort is felt when using the adhesive, so there is no particular lower limit to the average value of the bending stiffness. However, if the bending stiffness is too low, the handling of the support tends to worsen, so 0.010 cN·cm is preferable. 2 It is preferable that it be 1 / cm or more.

[0056] The bending stiffness using the KES method is measured using a pure bending tester (Kato Tech Co., Ltd., KES-FB2) according to the method described on pages 27-28 of "Standardization and Analysis of Texture Evaluation, 2nd Edition" (by Sueo Kawabata et al., edited by the Texture Measurement and Standardization Research Committee). Specifically, the support of the sample is gripped in the chuck at intervals of 1 cm in width over a length of 20 cm, with curvature K = -2.5 to 2.5 cm. -1 Within this range, the deformation speed is 0.50 cm. -1 By performing a pure bending operation with constant curvature at a constant velocity of / sec. and measuring the bending moment during this process, the bending stiffness per unit length (cN·cm) can be determined. 2 The bending stiffness per unit length obtained by measuring the bending stiffness ( / cm) is calculated by performing the measurement three times each in the longitudinal and transverse directions of the support, and then arithmetically averaging the measured values. In this invention, "longitudinal direction" refers to the production direction (flow direction) during the production of polyester fiber nonwoven fabric, and "transverse direction" refers to the direction perpendicular to the longitudinal direction, that is, the width direction during the production of polyester fiber nonwoven fabric.

[0057] The support of the present invention preferably has a laminate strength of 0.65 N / 25 mm or more, more preferably 0.80 N / 25 mm or more, and even more preferably 0.90 N / 25 mm or more, in order to prevent adhesive and polyester fiber nonwoven fabric from remaining on the skin when the adhesive patch containing the support is peeled off.

[0058] The laminate strength is measured by the following method. (i) Cut the support material to a size of 150 mm vertically x 50 mm horizontally. (ii) Craft tape (ASKUL Corporation's Genba no Chikara Laminated Craft Tape) is applied to both sides of the support, one side having a polyester film and the other side having a polyester fiber nonwoven fabric (for supports without a polyester fiber nonwoven fabric, the side having a fiber web). A roller with a load of 2000g is passed back and forth once to press the adhesive side of the craft tape against both main surfaces of the support. Then, 12.5mm is cut from both ends in the horizontal direction to create a measurement sample measuring 180mm in the vertical direction x 25mm in the horizontal direction (of which 30mm in the vertical direction is the chuck gripping area where the craft tape is folded back and the craft tape is bonded to itself). (iii) Peel off 2 mm of the measurement sample in the longitudinal direction from one end having a chuck gripping area, set the measurement sample on a constant-speed elongation tensile testing machine (Orientec, Tensilon) so that the chucks grip two chuck gripping areas of the measurement sample (chuck distance: 50 mm), and peel off the measurement sample at a tensile speed of 200 mm / min, and measure the tensile strength (N / 25 mm) when the chuck distance is 90 to 210 mm. Note that when peeling off the measurement sample, if the adhesion between the polyester film and polyester nonwoven fabric, and the constituent fibers of the polyester nonwoven fabric, is so strong that the polyester film and polyester nonwoven fabric of the support contained in the measurement sample do not separate, it shall be considered "unmeasurable". (iv) The average of the maximum and minimum tensile strengths was calculated for tensile strengths when the distance between chucks was 90 to 210 mm. The average of the maximum and minimum tensile strengths was calculated for three measurement samples, and the arithmetic mean was taken as the laminate strength (N / 25 mm).

[0059] As mentioned above, the support of the present invention is composed of a polyester film, a polyester fiber nonwoven fabric, and a fiber web containing undrawn polyester fibers, but it is preferable that all of them be composed of polyethylene terephthalate. As mentioned above, polyethylene terephthalate does not readily adsorb the active ingredient and can effectively exert its medicinal effect.

[0060] The support of the present invention is made from polyester film, polyester fiber nonwoven fabric and fiber web Therefore, the weight is not particularly limited, but it is 12-50g / m 2 Preferably, it is 14-45 g / m 2 It is more preferable that the amount be 16-40 g / m². 2 It would be even more preferable if that were the case.

[0061] Furthermore, the support is designed to minimize discomfort when the patch is applied to the skin and to prevent the patch from peeling off due to friction from clothing, etc. Therefore, the thickness of the support, excluding the polyester film, is less than 100 μm, and the thickness of the support is preferably 116 μm or less, more preferably 104 μm or less, and even more preferably 82 μm or less. On the other hand, if the thickness is too thin, the layer containing fibers that can participate in holding the adhesive containing the medicinal ingredient will be thin, and there is a risk that the fibers will not be able to adequately hold the adhesive, so it is preferable that the thickness be 17 μm or more.

[0062] The support of the present invention is formed by bonding a polyester film and a polyester fiber nonwoven fabric with undrawn polyester fibers of a fiber web. In order to prevent the support from tearing when peeled from the skin, the tensile strength of the support in both the longitudinal and transverse directions is preferably 5.0 N / 15 mm or more, more preferably 7.5 N / 15 mm or more, and even more preferably 10.0 N / 15 mm or more.

[0063] This "tensile strength" is determined by taking a sample piece measuring 15 mm in width and 150 mm in length from the support material and measuring the maximum load until the sample piece breaks using a constant-speed elongation tensile testing machine (Tensilon, manufactured by Orientec Co., Ltd.). This maximum load measurement is performed for three sample pieces, and the arithmetic mean of these maximum loads is taken as the tensile strength. The measurement is performed under conditions of a gripping distance of 100 mm and a tensile speed of 200 mm / min.

[0064] Furthermore, to ensure excellent flexibility, the support of the present invention preferably has an elongation rate of 5.0% or more in both the longitudinal and transverse directions, more preferably 7.5% or more, and even more preferably 10.0% or more.

[0065] This elongation rate (Sr, in %) refers to the percentage of the elongation of the sample piece at maximum load (Smax, in mm) [= (length at maximum load, in mm) - (grip spacing = 100 mm)] relative to the grip spacing (100 mm) when the tensile strength measurement described above was performed. In other words, it is the value obtained from the following formula. This measurement is performed three times, and the arithmetic mean of the above percentages is taken as the elongation rate. Sr = (Smax / 100) × 100 The support of the present invention is less likely to cause discomfort when the patch is applied to the skin, the patch is less likely to peel off due to friction with clothing, etc., and has a superior adhesive feel. Furthermore, the polyester fibers contained in the polyester fiber nonwoven fabric that constitutes the support are less likely to fall off, and the polyester fiber nonwoven fabric is less likely to be damaged by the adhesive applied to the patch. For this reason, the support of the present invention can be suitably used, for example, as a support for forming a patch (e.g., a poultice, plaster, tape formulation, etc.) by supporting an adhesive containing a medicinal ingredient, or as a support for forming a facial pack material by supporting a cosmetic gel or cosmetic liquid.

[0066] The adhesive patch of the present invention has an adhesive containing a medicinal ingredient on the polyester fiber nonwoven fabric side of the support as described above. Due to the anchoring effect, the adhesive is held in place by the polyester nonwoven fabric, making it difficult for the medicinal ingredient-containing adhesive to leak out. Furthermore, because peeling between the polyester film and the polyester fiber nonwoven fabric is unlikely to occur, the adhesive is less likely to remain on the skin along with the polyester fibers when the patch is removed.

[0067] The adhesive patch of the present invention can be exactly the same as a conventional adhesive patch, except that it uses the support material described above.

[0068] For example, the active ingredient is preferably one that is absorbed through the skin, and may be either a topical or systemic active ingredient. More specifically, examples of active ingredients include corticosteroids, analgesics and anti-inflammatory agents, hypnotics and sedatives, tranquilizers, antihypertensive agents, antihypertensive diuretics, antibiotics, anesthetics, antibacterial agents, antifungal agents, vitamins, coronary vasodilators, antihistamines, antitussives, sex hormones, antidepressants, cerebral circulation improvers, antiemetics, antitumor agents, and biopharmaceuticals. One or more of these active ingredients can be used in combination.

[0069] Examples of adhesives include acrylic adhesives made of acrylic polymers; rubber adhesives such as styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, polyisoprene, polyisobutylene, and polybutadiene; silicone adhesives such as silicone rubber, dimethylsiloxane-based, and diphenylsiloxane-based; vinyl ether adhesives such as polyvinyl methyl ether, polyvinyl ethyl ether, and polyvinyl isobutyl ether; vinyl ester adhesives such as vinyl acetate-ethylene copolymer; and polyester adhesives consisting of carboxylic acid components such as dimethyl terephthalate, dimethyl isophthalate, and dimethyl phthalate and polyhydric alcohol components such as ethylene glycol. The adhesive may consist of one type or two or more types.

[0070] The amount of active ingredient in the adhesive is not particularly limited, as it varies depending on the type of active ingredient and the purpose of administration. However, generally, it is preferable that the active ingredient accounts for 0.5 to 40 mass%, and more preferably 1 to 30 mass%, of the adhesive.

[0071] The adhesive patch of the present invention can be manufactured by applying an adhesive solution containing a medicinal ingredient to the polyester fiber nonwoven fabric surface of the aforementioned support and drying it, or by applying an adhesive solution to a release paper, drying it to form an adhesive layer, and then transferring the adhesive layer to the polyester fiber nonwoven fabric surface of the aforementioned support. [Examples]

[0072] Examples of the present invention are described below, but the present invention is not limited to these examples.

[0073] (Example 1) Thickness 7 μm, basis weight 9.8 g / m² 2 A biaxially oriented polyethylene terephthalate film was prepared. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate fibers (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 90:10, and then processed using a carding machine to obtain a basis weight of 6.0 g / m². 2 A polyester fiber nonwoven fabric was formed. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate fibers (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 60:40, and then processed using a carding machine to obtain a basis weight of 6.0 g / m². 2 A fiber web was formed. Next, the polyethylene terephthalate film and the polyester fiber nonwoven fabric were laminated with a fiber web in between. A thermal calendering treatment was performed by passing the laminated

[0074] (Example 2) Thickness 7 μm, basis weight 9.8 g / m² 2 A biaxially oriented polyethylene terephthalate film was prepared. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate fibers (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 90:10, and then processed using a carding machine to obtain a basis weight of 6.0 g / m². 2 A polyester fiber nonwoven fabric was formed. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate fibers (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 80:20, and then processed using a carding machine to obtain a basis weight of 6.0 g / m². 2 A fiber web was formed. Next, the polyethylene terephthalate film and the polyester fiber nonwoven fabric were laminated together via a fiber web, and a thermal calendering treatment was performed under the same conditions as in Example 1 to produce a support.

[0075] (Comparative Example 1) Thickness 12 μm, basis weight 16.8 g / m² 2 A biaxially oriented polyethylene terephthalate film was prepared. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.45 dtex, fiber length: 38 mm) were opened using a carding machine to create a crisscross web. Next, this crisscross web was entangled with a water flow to produce a fabric with a basis weight of 50 g / m². 2 A polyester fiber nonwoven fabric was formed. The water flow entanglement conditions were as follows. 1. Shower: 0.1 MPa [One side (Side A)] 2. 7 MPa (Side A) from a nozzle plate with a nozzle diameter of 0.13 mm and a nozzle pitch of 0.6 mm. 3. 7 MPa (Side A) from a nozzle plate with a nozzle diameter of 0.13 mm and a nozzle pitch of 0.6 mm. 4. 12 MPa [the other side (side B)] from a nozzle plate with a nozzle diameter of 0.13 mm and a nozzle pitch of 0.6 mm. 5. 10 MPa (side B) from a nozzle plate with a nozzle diameter of 0.13 mm and a nozzle pitch of 0.6 mm. 6. 9.5 MPa (Side A) from a nozzle plate with a nozzle diameter of 0.13 mm and a nozzle pitch of 0.6 mm. 7. 11 MPa (Side A) from a nozzle plate with a nozzle diameter of 0.13 mm and a nozzle pitch of 0.6 mm. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate fibers (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 60:40, and then processed using a carding machine to obtain a basis weight of 6.0 g / m². 2 A fiber web was formed. Next, the polyethylene terephthalate film and the polyester fiber nonwoven fabric were laminated together via a fiber web, and a thermal calendering treatment was performed under the same conditions as in Example 1 to produce a support.

[0076] (Comparative Example 2) Thickness 7 μm, basis weight 9.8 g / m² 2 A biaxially oriented polyethylene terephthalate film was prepared. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate fibers (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 60:40, and then processed using a carding machine to obtain a basis weight of 12 g / m². 2 A fiber web was formed. Next, the polyethylene terephthalate film and the fiber web were subjected to a heat calendering treatment under the same conditions as in Example 1 to bond the polyethylene terephthalate film and the fiber web together, thereby producing a support.

[0077] (Comparative Example 3) Thickness 12 μm, basis weight 16.8 g / m² 2 A biaxially oriented polyethylene terephthalate film was prepared. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 60:40, and then processed using a carding machine to achieve a basis weight of 30 g / m². 2 A fiber web was formed. Next, the polyethylene terephthalate film and the fiber web were subjected to a heat calendering treatment under the same conditions as in Example 1 to bond the polyethylene terephthalate film and the fiber web together, thereby producing a support.

[0078] (Comparative Example 4) Thickness 7 μm, basis weight 9.8 g / m² 2 A biaxially oriented polyethylene terephthalate film was prepared. Furthermore, stretched polyethylene terephthalate fibers (fineness: 1.1 dtex, fiber length: 38 mm) and unstretched polyethylene terephthalate (fineness: 4.0 dtex, fiber length: 38 mm) were blended in a mass ratio of 90:10, and processed using a carding machine to achieve a basis weight of 12 g / m². 2A polyester fiber nonwoven fabric was formed. Next, the polyethylene terephthalate film and the polyester nonwoven fabric were subjected to a heat calendering treatment under the same conditions as in Example 1 to bond the polyethylene terephthalate film and the polyester fiber nonwoven fabric together, thereby producing a support.

[0079] (Evaluation of the support) (1) Measurement of average bending stiffness Using the method described above, the bending stiffness of the support in the longitudinal and transverse directions was measured, and the average value of the bending stiffness in the longitudinal and transverse directions was calculated. (2) Measurement of laminate strength The laminate strength was measured using the method described above.

[0080] Table 1 shows the physical properties, average bending stiffness, and laminate strength of the support material of the example, and Table 2 shows the physical properties, average bending stiffness, and laminate strength of the support material of the comparative example.

[0081] [Table 1]

[0082] [Table 2]

[0083] When comparing the support of the example with the support of Comparative Example 1, which has a thicker support, and the supports of Comparative Examples 2 and 3, which do not use polyester fiber nonwoven fabric, it was found that the example had a lower average bending stiffness. A lower bending stiffness in the support means that the support bends easily with a small force and is soft. Therefore, when an ointment is applied to the support and it is attached to the skin, the support conforms easily to the skin, resulting in a superior feel when attached.

[0084] Furthermore, when comparing the support of the example with the support of Comparative Example 4, which does not use a fiber web, the support of the example had high lamination strength, and when the adhesive containing the support was peeled off, the adhesive and polyester fiber nonwoven fabric were less likely to remain on the skin. [Industrial applicability]

[0085] The support of the present invention can adequately hold the adhesive with its fibers and can suppress the leakage of the adhesive containing the medicinal ingredient. Therefore, it can be suitably used as a support for adhesive patches (e.g., poultices, plasters, tapes, etc.) that contain an adhesive with a medicinal ingredient.

Claims

1. A support for adhesives, wherein a polyester film and a polyester fiber nonwoven fabric mainly composed of polyester fibers having an average fiber length of 25 mm or more and 100 mm or less are bonded together by deformation of the undrawn polyester fibers in a fiber web containing undrawn polyester fibers, The thickness of the support for the adhesive patch, excluding the polyester film, is 90 μm or less. The polyester film is a stretched polyethylene terephthalate film with a thickness of 7 μm or less. The aforementioned polyester fiber nonwoven fabric contains 90 mass% or more of stretched polyethylene terephthalate fibers and 10 mass% or less of unstretched polyethylene terephthalate fibers as polyester fibers. The aforementioned fiber web is a support for adhesive patches, comprising 20 to 40 mass% of undrawn polyethylene terephthalate fibers as undrawn polyester fibers and 80 to 60 mass% of drawn polyethylene terephthalate fibers.

2. The average value of the bending stiffness in the longitudinal and transverse directions according to the KES method is 0.050 cN·cm. ２ A support for a patch according to claim 1, wherein the length is less than or equal to / cm.

3. An adhesive patch comprising an adhesive on the polyester fiber nonwoven fabric side of the support for the adhesive patch according to Claim 1 or Claim 2.

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