Intraperitoneal thermo-pressurized gas circulation system and intraperitoneal gas delivery system including a two-fluid nozzle

Abstract

A system including a gas circulator and a temperature controller for circulating a thermal gas into the abdominal cavity, and a drug injector for effectively injecting a drug into the abdominal cavity together with the gas, is disclosed. The system of the present invention is used as a system for intraperitoneal hyperthermic anti-cancer chemotherapy, and can maximize the anti-cancer therapeutic effect by more effectively delivering a small amount of anti-cancer drug to cancer cells while maintaining a constant gas temperature in the abdominal cavity.

Description

Technical Field

[0001] The present invention relates to an intraperitoneal hyperthermic pressurized gas circulation system. More specifically, the present invention relates to a system including a gas circulation device capable of circulating warm gas in the abdominal cavity, a temperature control device, and a drug injection device capable of effectively injecting an intraperitoneal drug together with the gas. Further, the present invention relates to an intraperitoneal gas supply system including a two-fluid nozzle for effectively injecting a drug such as an anticancer agent into the abdominal cavity to treat cancer or the like in a patient, particularly an intraperitoneal hyperthermic pressurized gas circulation system. The system of the present invention is particularly useful as a system for intraperitoneal hyperthermic anticancer chemotherapy.

Background Art

[0002] In recent years, as a method for solving the problem that the efficiency of drugs administered orally or intravascularly to cancer cells metastasized into the abdominal cavity is low, intraperitoneal anticancer chemotherapy (IPC) has been performed.

[0003] In the case of pressurized intraperitoneal aerosol chemotherapy (PIPAC), by directly injecting the atomized drug into cancer cells, an anticancer treatment effect can be obtained even with about 10% of the dosage of the anticancer agent used in hyperthermic intraperitoneal chemotherapy (HIPEC). However, there is a problem that it is difficult to maintain the intraperitoneal temperature at about 42°C at which cancer cells die due to the body's thermoregulation (36°C).

[0004] Also, in the case of HIPEC, although it is possible to maintain the temperature at about 42°C, there is a problem that the dosage of the anticancer agent becomes large and side effects of the anticancer treatment are likely to occur due to extensive surgery.

[0005] Furthermore, in the case of existing methods, there are problems that it is difficult to inject the anticancer drug evenly in the abdominal cavity and it is also difficult to adjust the injection direction.

Prior Art Documents

[0006] [Patent Document 1] Korean Patent No. 1866455 [Overview of the project] [Problems that the invention aims to solve]

[0007] This invention was made to solve the problems described above, and in one aspect, aims to provide an intraperitoneal thermo-pressurized gas circulation system that can enhance therapeutic effects by including a gas circulation device and a temperature control device that can circulate gas within the abdominal cavity at a constant temperature and pressure.

[0008] In other aspects, the present invention aims to provide a system including a drug and gas injection device that can effectively inject a drug into the abdominal cavity together with gas and more effectively deliver drugs such as anticancer agents to lesions in the abdominal cavity. [Means for solving the problem]

[0009] To achieve this objective, in one aspect, a system (apparatus) for circulating intraperitoneal thermal pressurized gas according to an exemplary embodiment of the present invention includes a gas hose connected to the abdominal cavity of an individual and a pump connected to the gas hose, and a gas circulation device for circulating gas discharged from the abdominal cavity back into the abdominal cavity; and a temperature control device for controlling the gas temperature of the gas circulation device so that the gas inside the abdominal cavity reaches a constant temperature.

[0010] The gas circulation device includes an intraperitoneal gas injection unit for introducing gas into the abdominal cavity; and a circulation unit for discharging gas from the abdominal cavity to the outside, circulating the gas outside the abdominal cavity, and introducing it back into the abdominal cavity; the temperature control device includes a temperature sensor for measuring one or more of the gas temperatures of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity; a heating device for providing heat to at least a portion of the gas hose of the gas circulation device; and a temperature control unit connected to the heating device and the temperature sensor; the temperature control unit may control the temperature of the heating device based on the measurement value of the temperature sensor so that the gas temperature inside the abdominal cavity becomes a constant temperature.

[0011] Furthermore, the intraperitoneal gas injection unit may include a drug and gas injection device that injects a drug along with the gas when introducing gas into the peritoneal cavity of an individual.

[0012] On the other hand, in order to achieve the aforementioned objectives, in other respects, a system for providing intraperitoneal gas according to an exemplary embodiment of the present invention includes a drug and gas injector, the drug and gas injector including a drug syringe for supplying a drug; a drug and gas injector that receives a supply of gas and a supply of drug from the drug syringe, is fitted into the peritoneal cavity and administers the drug and gas into the peritoneal cavity of an individual; and a two-fluid nozzle positioned at the end of the drug and gas injecting both the drug and gas into the peritoneal cavity.

[0013] Furthermore, the system may be a system for circulating intraperitoneal thermo-pressurized gas, particularly a system for intraperitoneal thermo-anti-cancer chemotherapy.

[0014] Such a system includes a gas hose connected to the abdominal cavity of an individual and a pump connected to the gas hose for circulating gas, and a gas circulation device that circulates the gas discharged from the abdominal cavity back into the abdominal cavity; and a temperature control device that controls the gas temperature of the gas circulation device so that the gas inside the abdominal cavity is at a constant temperature. Here, the intraperitoneal gas injection section of the gas circulation device includes the aforementioned drug and gas injection device. [Effects of the Invention]

[0015] A system according to an exemplary embodiment of the present invention can effectively maintain the temperature inside the abdominal cavity by supplying a gas, such as carbon dioxide, to inflate the abdominal cavity of an individual, and by circulating the gas inside the abdominal cavity with a circulation pump in the circulation unit while heating it.

[0016] Furthermore, according to the system of an exemplary embodiment of the present invention, by injecting a gas, such as carbon dioxide, to inflate the abdominal cavity of an individual, and a atomized drug, such as an anticancer agent, into the inflated abdominal cavity using a two-fluid nozzle, the anticancer agent injected at high pressure can be atomized to a higher level and sprayed evenly throughout the abdominal cavity, and the spray direction can be adjusted very easily. The atomized anticancer agent can spread evenly throughout the inflated abdominal cavity and act effectively on the peritoneum where cancer cells have metastasized, thereby maximizing the anticancer treatment effect.

[0017] Therefore, the system according to an exemplary embodiment of the present invention can be used as a system for intraperitoneal hyperthermic anticancer chemotherapy, and can maximize the anticancer treatment effect by more effectively delivering a small amount of anticancer drug to cancer cells while maintaining the gas temperature in the peritoneal cavity at a constant temperature. [Brief explanation of the drawing]

[0018] [Figure 1] This is a schematic diagram showing the configuration of a system device according to the first embodiment of the present invention. [Figure 2] This is an enlarged partial cross-sectional view of portion A in the system shown in Figure 1. [Figure 3] Figure 1 is a schematic diagram illustrating the system equipment along with the flow of chemicals and gases. [Figure 4] This is a schematic diagram showing the configuration of a system device according to a second embodiment of the present invention. [Figure 5] Figure 4 is a schematic diagram illustrating the system equipment shown, along with the flow of chemicals and gases. [Figure 6] This is a schematic diagram showing the configuration of a system device according to a third embodiment of the present invention. [Figure 7]It is a schematic diagram that schematizes the system device shown in FIG. 6 together with the flow of the drug and gas. [Figure 8] It is a schematic diagram showing the configuration of the system device according to the fourth embodiment of the present invention. [Figure 9] It is a schematic diagram that schematizes the system device shown in FIG. 8 together with the flow of the drug and gas. [Figure 10] It is a schematic diagram showing the configuration of the system device according to the fifth embodiment of the present invention. [Figure 11] It is a schematic diagram that schematizes the system device shown in FIG. 10 together with the flow of the drug and gas.

Mode for Carrying Out the Invention

[0019] one aspect On one side, when detailing an exemplary embodiment of the present invention, it is as follows.

[0020] A system (device) according to an exemplary embodiment of one side of the present invention is a system (device) that circulates intraperitoneal hyperthermic pressurized gas, and generally includes a gas circulation device and a temperature control device.

[0021] The gas circulation device includes a gas hose connected to the abdominal cavity of an individual and one or more pumps connected to the gas hose for circulating and pressurizing the gas, and circulates the gas discharged from the abdominal cavity back into the abdominal cavity.

[0022] In one embodiment, the gas circulation device may include an intraperitoneal gas injection part for injecting pressurized gas into the abdominal cavity and a circulation part for discharging gas from the abdominal cavity to the outside, circulating the gas outside the abdominal cavity, and injecting it back into the abdominal cavity.

[0023] In one embodiment, the intraperitoneal gas injection part may include one or more drug and gas injection devices that inject drugs together with gas when injecting gas into the abdominal cavity of an individual. Further, separately from the drug and gas injection devices, it may further include one or more cannulators (gas supply trocars) cannulated into the abdominal cavity to supply gas.

[0024] In one embodiment, the drug and gas injection device may include a drug syringe for supplying the drug, a drug and gas injector connected to a gas hose to receive pressurized gas, a drug syringe for supplying the drug, and a drug and gas injector that is fitted into the abdominal cavity to administer the drug and gas into the abdominal cavity of an individual. A nozzle for injecting the drug and gas into the abdominal cavity may be located at the end of the drug and gas injector.

[0025] In one embodiment, the drug and gas dispenser may be configured to include, for example, a head, a body connected to the head, and an abdominal casing portion at the lower part of the body. A gas hose may be connected to one or more of the head and body to supply gas. Furthermore, as will be described later, a temperature sensor may be attached to one side of the body.

[0026] In one embodiment, the nozzle is preferably a two-fluid nozzle, as will be described later. The pressure during injection from the nozzle may be less than the intraperitoneal pressure, for example, 6 to 14 mmHg or 6 to 15 mmHg.

[0027] In one embodiment, the gas circulation unit may include a circulation hose, which is a gas hose for the circulation unit, and one or more circulation pumps connected to the circulation hose to increase the pressure of the circulating gas.

[0028] The circulating gas from the gas circulation section may be discharged from the gas discharge section, circulated through the circulation section by a pump, heated and / or pressurized after passing through a temperature control device as described later, and then supplied again to the intraperitoneal gas injection section.

[0029] Here, the circulating gas in the gas circulation unit may be supplied to the drug and gas dispenser, or to a gas inlet trocar fitted into the abdominal cavity, or to the drug and gas dispenser and the gas inlet trocar, respectively.

[0030] In one embodiment, the gas circulation device may further include a gas supply unit for supplying gas. The gas supply unit may be configured to be connected to one or more of the intraperitoneal gas injection unit and the gas circulation unit of the gas circulation device.

[0031] For example, in one embodiment, a gas supply unit may be connected to the drug and gas injection device of the intraperitoneal gas injection unit so that gas is supplied to it. Such a gas supply unit may include a gas injector that generates gas and a gas hose (first hose) through which the gas from the gas injector flows and which is connected to the drug and gas injection device. The gas supply unit may further include a pump that increases the pressure of the gas flowing through the gas hose.

[0032] In one embodiment, the gas hose of the gas supply unit may further include one or more branched gas hoses (second hoses). These branched hoses may be connected to the circulation unit.

[0033] In one embodiment, a gas supply unit that supplies gas to the circulation unit may be directly connected. Such a gas supply unit may include a gas injector that generates gas and a gas hose (third hose) (not shown) through which the gas from the gas injector flows and which is connected to the circulation unit.

[0034] In one embodiment, the gas circulation unit may include one or more valves for connecting two or more gas hoses.

[0035] For example, the circulation unit may include a valve (first valve) that connects the circulation hose to a hose (second hose) branched from the gas hose (first hose) of the aforementioned gas supply unit, and discharges gas to the drug and gas dispenser.

[0036] Furthermore, the circulation unit may include a valve (second valve) that connects the third hose and the circulation hose and discharges gas to the circulation pump.

[0037] Furthermore, the circulation unit may further include a valve (third valve) into which gas flows from the circulation pump and supplies gas to the drug and gas dispenser. One or more gas hoses may be connected from the third valve to the drug and gas dispenser. For example, two gas hoses may be connected from the third valve to different positions on the drug and gas dispenser, or one gas hose may be connected from the third valve to the drug and gas dispenser and another gas hose may be connected to the second trocar.

[0038] On the other hand, the temperature control device controls the gas temperature of the gas circulation device so that the gas inside the abdominal cavity reaches a constant temperature. To this end, the temperature control device may measure one or more of the gas temperatures from the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, and then control the intraperitoneal gas temperature based on these measurements.

[0039] Specifically, in one embodiment, the temperature control device may include one or more temperature sensors that measure one or more of the gas temperatures of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, a heating device such as a heating wire coil that provides heat to at least a portion of the gas hose of the gas circulation device, and a temperature control unit (controller) connected to the heating device and the temperature sensors.

[0040] The temperature control unit (controller) may control the temperature of the heating device based on the measurement value of the temperature sensor so that the gas temperature inside the abdominal cavity is maintained at a constant temperature, for example, 38°C to 42°C.

[0041] Multiple temperature sensors may be provided. That is, the system of the present invention may include at least a first temperature sensor for measuring the temperature of gas injected into the abdominal cavity, and may further include one or more sensors for measuring the temperature of the gas hose of the gas circulation device. For example, it may further include one or more of a second temperature sensor for measuring the temperature of the gas in the circulation hose of the circulation unit, and a third temperature sensor for measuring the temperature of the gas supplied from the circulation unit to the drug and gas dispenser.

[0042] In one embodiment, the amount of gas supplied from each gas hose may be adjusted based on the measurement value of one or more of the second and third temperature sensors. That is, since the temperature of the gas flowing through gas hoses such as the circulation hose, first hose, and second hose may differ, the gas flow rate of each gas hose may be adjusted based on the temperature measurement value of one or more of the second and third temperature sensors mentioned above to adjust the temperature of the gas introduced into the abdominal cavity.

[0043] In one embodiment, the gas of the system may be carbon dioxide.

[0044] In one embodiment, the system for circulating intraperitoneal thermo-pressurized gas is a system specifically for intraperitoneal thermo-anti-cancer chemotherapy, and the drug may be an anticancer agent.

[0045] Thus, by using the aforementioned system, it is possible to effectively maintain the temperature and pressure of the gas inside the peritoneal cavity when performing hyperthermic anticancer chemotherapy, and to thoroughly inject the drug into the peritoneal cavity, thereby maximizing the anticancer treatment effect.

[0046] Other aspects On the other hand, in other respects, exemplary embodiments of the present invention are described in detail as follows.

[0047] In other respects, exemplary systems (apparatus) of the present invention include intraperitoneal gas delivery systems including drug and gas injection devices, in particular systems for circulating intraperitoneal thermo-pressurized gas, and in particular systems for intraperitoneal thermo-anti-cancer chemotherapy.

[0048] The system may include the aforementioned chemical, a gas circulation device including a gas injection device, and a temperature control device. These will be described in detail below.

[0049] The gas circulation device includes a gas hose connected to the abdominal cavity of an individual and one or more pumps connected to the gas hose for circulating and pressurizing the gas, thereby circulating the gas discharged from the abdominal cavity back into the abdominal cavity.

[0050] In one embodiment, the gas circulation device may include an intraperitoneal gas injection unit for introducing pressurized gas into the abdominal cavity, and a circulation unit for discharging gas from the abdominal cavity to the outside, circulating the gas outside the abdominal cavity, and then introducing it back into the abdominal cavity.

[0051] In one embodiment, the intraperitoneal gas injection unit may include one or more of the aforementioned drug and gas injection devices that inject a drug along with the gas when gas is injected into the abdominal cavity of an individual. It may further include one or more sheathing devices (gas supply trocars) that are fitted into the abdominal cavity separately from the drug and gas injection devices to supply gas.

[0052] In one embodiment, the drug and gas injection device may include a drug syringe for supplying the drug, a drug and gas injector connected to a gas hose to receive pressurized gas, a drug syringe for supplying the drug, and a drug and gas injector that is fitted into the abdominal cavity to administer the drug and gas into the abdominal cavity of an individual. A two-fluid nozzle for injecting the drug and gas into the abdominal cavity may be positioned at the end of the drug and gas injector.

[0053] In one embodiment, the drug and gas dispenser may be configured to include, for example, a head, a body connected to the head, and an abdominal casing at the lower part of the body. A gas hose may be connected to one or more of the head and body to supply gas. Furthermore, as will be described later, a temperature sensor may be attached to one side of the body.

[0054] In one embodiment, the two-fluid nozzle has a structure in which both a drug and a gas are administered. For example, the two-fluid nozzle may include one or more drug lines for supplying the drug, one or more gas lines which are gas supply passages, and may have one or more mixing chambers in which the gas and drug are selectively mixed. The two-fluid nozzle may also include one or more outlets which are micropores located in front of the nozzle.

[0055] In one embodiment, the pressure during injection from the two-fluid nozzle is set to a pressure lower than the intraperitoneal pressure, for example, 6-14 mmHg or 6-15 mmHg. The injection pressure may be adjusted according to the size of each line, the size of the micropores, and the presence or absence of a mixing chamber.

[0056] Using a two-fluid nozzle in this way not only results in excellent atomization because both the high-pressure drug and pressurized gas are injected into the abdominal cavity, but also makes it much easier to adjust the injection direction compared to a single-fluid nozzle that only delivers the drug, which makes it difficult to spray into the desired lesion in the abdominal cavity and difficult to control the injection direction. Therefore, using a two-fluid nozzle makes it extremely suitable for performing intraperitoneal anticancer therapy.

[0057] In one embodiment, the gas circulation unit may include a circulation hose, which is a gas hose for the circulation unit, and one or more circulation pumps connected to the circulation hose to increase the pressure of the circulating gas.

[0058] The circulating gas in the gas circulation section may be discharged from the gas discharge section, circulated through the circulation section by a pump, heated and / or pressurized after passing through a temperature control device as described later, and then supplied again to the intraperitoneal gas injection section.

[0059] Here, the circulating gas in the gas circulation unit may be supplied to the drug and gas dispenser, or to a gas inlet trocar fitted into the abdominal cavity, or to the drug and gas dispenser and the gas inlet trocar, respectively.

[0060] In one embodiment, the gas circulation device may further include a gas supply unit for supplying gas. The gas supply unit may be configured to be connected to one or more of the intraperitoneal gas injection unit and the gas circulation unit of the gas circulation device.

[0061] For example, in one embodiment, a gas supply unit may be connected to the drug and gas injection device of the intraperitoneal gas injection unit so that gas is supplied to it. Such a gas supply unit may include a gas injector that generates gas and a gas hose (first hose) through which the gas from the gas injector flows and which is connected to the drug and gas injection device. The gas supply unit may further include a pump that increases the pressure of the gas flowing through the gas hose.

[0062] In one embodiment, the gas hose of the gas supply unit may further include one or more branched gas hoses (second hoses). These branched hoses may be connected to the circulation unit.

[0063] In one embodiment, a gas supply unit that supplies gas to the circulation unit may be directly connected. Such a gas supply unit may include a gas injector that generates gas and a gas hose (third hose) (not shown) through which the gas from the gas injector flows and which is connected to the circulation unit.

[0064] In one embodiment, the gas circulation section may include one or more valves for connecting two or more gas hoses.

[0065] For example, the circulation unit may include a valve (first valve) that connects the circulation hose and a hose (second hose) branched from the gas hose (first hose) of the aforementioned gas supply unit, and discharges gas to the drug and gas dispenser.

[0066] Furthermore, the circulation unit may include a valve (second valve) that connects the third hose and the circulation hose and discharges gas to the circulation pump.

[0067] Furthermore, the circulation unit may further include a valve (third valve) into which gas flows from the circulation pump and supplies gas to the drug and gas dispenser. One or more gas hoses may be connected from the third valve to the drug and gas dispenser. For example, two gas hoses may be connected from the third valve to different positions on the drug and gas dispenser, or one gas hose may be connected from the third valve to the drug and gas dispenser and another gas hose may be connected to the second trocar.

[0068] On the other hand, the temperature control device controls the gas temperature of the gas circulation device so that the gas inside the abdominal cavity reaches a constant temperature. To this end, the temperature control device may measure one or more of the gas temperatures from the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, and then control the intraperitoneal gas temperature based on these measurements.

[0069] Specifically, in one embodiment, the temperature control device may include one or more temperature sensors that measure one or more of the gas temperatures of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, a heating device such as a heating wire coil that provides heat to at least a portion of the gas hose of the gas circulation device, and a temperature control unit (controller) connected to the heating device and the temperature sensors.

[0070] The temperature control unit (controller) may control the temperature of the heating device based on the measurement value of the temperature sensor so that the gas temperature inside the abdominal cavity is maintained at a constant temperature, for example, 38°C to 42°C.

[0071] Multiple temperature sensors may be provided. That is, the system of the present invention may include at least a first temperature sensor for measuring the temperature of gas injected into the abdominal cavity, and may further include one or more sensors for measuring the temperature of the gas hose of a gas circulation device. For example, it may further include one or more of a second temperature sensor for measuring the temperature of the gas in the circulation hose of the circulation unit, and a third temperature sensor for measuring the temperature of the gas supplied from the circulation unit to the drug and gas dispenser.

[0072] In one embodiment, the amount of gas supplied from each gas hose may be adjusted based on the measurement values ​​of one or more of the second and third temperature sensors. That is, since the temperature of the gas flowing through gas hoses such as the circulation hose, first hose, and second hose may differ, the gas flow rate of each gas hose may be adjusted based on the temperature measurement values ​​of one or more of the second and third temperature sensors mentioned above to adjust the temperature of the gas introduced into the abdominal cavity.

[0073] In one embodiment, the system is a system for intraperitoneal hyperthermic anticancer chemotherapy, the drug may be an anticancer agent, and the gas may be carbon dioxide.

[0074] As described above, by using the system of the present invention, it is possible to effectively maintain the temperature and pressure of the gas inside the peritoneal cavity when performing hyperthermic anticancer chemotherapy, and to thoroughly inject the drug into the peritoneal cavity, thereby maximizing the anticancer treatment effect.

[0075] The following describes in more detail, with reference to the drawings, examples of systems relating to the exemplary embodiment of the present invention mentioned above. It should be understood that these examples are merely for illustrative purposes of the present invention and do not limit the technical idea, core configuration, or operation of the present invention.

[0076] Descriptions of configurations and operations that are repeated in each of the following embodiments will be omitted. For example, the nozzle in Figure 2 can be used in all embodiments. [Examples]

[0077] First Example Figure 1 is a schematic diagram showing the configuration of System 1 (hereinafter referred to as "System 1"), which includes a gas circulation device and a temperature control device for maintaining intraperitoneal temperature according to one embodiment of the present invention.

[0078] Figure 2 is an enlarged partial cross-sectional view of portion A in the system shown in Figure 1.

[0079] Figure 3 is a schematic diagram illustrating the system apparatus shown in Figure 1, along with the flow of chemicals and gases.

[0080] Referring to Figures 1-3, the system 1 (device) includes a gas circulation device that introduces pressurized gas into the abdominal cavity 2 of an individual to expand the space inside the abdominal cavity, discharges it to the outside of the abdominal cavity, heats and / or pressurizes it, and then introduces it back into the abdominal cavity, and a temperature control device that controls the temperature of the gas circulation device. This ensures that the expanded space inside the abdominal cavity 2 maintains a constant temperature and pressure.

[0081] The gas circulation device may include an intraperitoneal gas injection unit for introducing intraperitoneal pressurized gas, which includes a drug and gas injection device 20 for finely spraying gas and drug into the intraperitoneal cavity 2, and a gas supply unit 10 for supplying pressurized gas to the drug and gas injection device 20. The gas circulation device may also include a circulation unit 30 for circulating the gas.

[0082] First, the gas supply unit 10 may include a gas injector 11 that generates gas to expand the abdominal cavity 2 of the individual, a pump 12 that supplies the generated gas to a drug injection device 20, and a first hose 13 that is connected from the gas injector 11 to the drug injection device 20 to transport the gas.

[0083] The gas injector 11 supplies gas at a pressure of, for example, 12 to 14 bar, and the pump 12 supplies the gas to the drug and gas injection device 20 at a pressure of, for example, approximately 3 bar. In this case, the gas may be, for example, carbon dioxide.

[0084] The drug and gas injection device 20 is a device that atomizes a drug injected at high pressure together with gas and sprays it evenly into the abdominal cavity 2, and includes a drug (e.g., anticancer drug) syringe 21, a drug and gas injector 22 connected thereto, and a nozzle 23 at the end of the drug and gas injector.

[0085] The drug syringe 21 supplies the drug to be administered into the abdominal cavity 2 to the drug and gas dispenser 22 at high pressure. At this time, the drug on the drug syringe 21 may be supplied to the drug and gas dispenser 22 at a pressure of approximately 1500 kPa or less.

[0086] The drug and gas dispenser 22 receives pressurized gas from the gas supply unit 10 and drug from the drug syringe 21, and discharges the gas and drug into the abdominal cavity 2 of the individual. At this time, a nozzle 23 is installed at the end of the drug and gas dispenser 22 in order to atomize and spray the drug.

[0087] Here, preferably, the nozzle 23 may be a two-fluid nozzle 23', as shown in Figure 2. Figure 2 shows a cross-sectional view of the two-fluid nozzle 23', from which both gas and chemical are ejected. Specifically, the chemical supplied through the chemical line 231 and the gas supplied through the gas line 232 are mixed in the mixing chamber 233 and finely ejected from the outlet 234.

[0088] As described above, System 1 according to a preferred embodiment of the present invention atomizes the drug using the principle of a two-fluid nozzle, exhibiting a superior degree of atomization compared to the one-fluid nozzle currently used in existing PIPACs, and also allowing for easy adjustment of the spray direction. In the case of anticancer drugs atomized in this way, they spread evenly throughout the expanded abdominal cavity 2 and effectively act on the peritoneum where cancer cells have metastasized.

[0089] Furthermore, a first temperature sensor 42 for measuring the temperature of the gas injected into the abdominal cavity 2 may be placed at the end of the nozzle of the drug and gas injection device 20. As will be described later, by measuring the temperature of the gas with the first temperature sensor 42, the temperature of the gas discharged into the abdominal cavity of the individual can be maintained at 38 to 42°C, preferably 41 to 42°C, and more preferably 42°C. This increases the penetration of anticancer drugs into the patient's peritoneal carcinomatosis, thereby maximizing the anticancer treatment effect.

[0090] On the other hand, the gas injected into the abdominal cavity of the individual pressurizes the inner wall of the abdominal cavity, causing it to expand, and is then expelled and circulates.

[0091] For this purpose, the circulation unit 30 expels gas from the abdominal cavity to the outside, collects the gas in the system 1, circulates it outside the abdominal cavity, and then reintroduces it into the abdominal cavity.

[0092] Specifically, the circulation unit 30 may include a sheathed device (gas discharge trocar; hereinafter referred to as the first trocar) 31 that is sheathed into the abdominal cavity to discharge gas, a circulation pump 32, a circulation hose 33, and a circulation valve 34. That is, the first trocar 31 is an intraperitoneal gas recovery device that is inserted into the abdominal cavity 2 to recover gas from the abdominal cavity 2. The recovered gas is supplied to the circulation valve 34 through the circulation hose 33. At this time, the circulation pump 32 pressurizes the gas so that the recovered gas can be circulated.

[0093] On the other hand, gas loss may occur during the process of recovering the gas that has circulated within the abdominal cavity 2 onto the system 1. An amount of gas equivalent to the lost gas may be supplied to the circulation valve 34 through a second hose 35 branched between the gas injector 11 and the pump 12.

[0094] The circulation valve 34 can supply or shut off the gas recovered from the abdominal cavity 2 and / or the gas supplied by the second hose 35 to the drug and gas dispenser 22 by opening and closing the valve.

[0095] The temperature control device may include a temperature sensor for measuring the temperature of the gas in order to control the temperature of the gas to a constant temperature, a heating wire coil (heating device) for heating the gas hose, and a temperature control unit (controller) 40 for controlling the heating wire coil based on the measurement value of the temperature sensor.

[0096] The temperature control device may include a heating wire coil 41 wound around the first hose 13, the second hose 35, and the circulation hose 33, respectively, a first temperature sensor 42, a second temperature sensor 43, and a third temperature sensor 44. Incidentally, for convenience, the heating wire coils 41 wound around the first hose 13, the second hose 35, and the circulation hose 33 may be referred to as the first heating wire coil, the second heating wire coil, and the third heating wire coil, respectively.

[0097] The temperature control unit (controller) 40 can maintain a constant gas temperature by adjusting the voltage applied to the heating wire coil 41 and the resulting heat generation of the heating wire coil 41 based on the temperatures measured by the respective temperature sensors 42, 43, and 44. This makes it possible to maintain a constant gas temperature inside the abdominal cavity 2 of the individual.

[0098] The following section will explain drug injection and maintenance of intraperitoneal temperature, with particular reference to Figure 3.

[0099] When the drug and gas are discharged into the abdominal cavity 2 of the individual, the circulation valve 34 may be closed. In this case, the gas supplied to the drug dispenser 22 is the gas supplied from the gas supply unit 10, and the supply of gas through the circulation valve 34 connected to the circulation hose 33 and the second hose 35 is closed. The temperature of the drug and gas discharged into the abdominal cavity 2 of the individual is measured by the first temperature sensor 42, and the temperature control unit 40 controls the heating device based on the measurement value of the first temperature sensor 42 so that the temperature inside the abdominal cavity 2 is maintained at 38 to 42°C, preferably 41 to 42°C, and more preferably 42°C, as described above.

[0100] Specifically, the temperature control unit 40 can adjust the temperature of the gas supplied through the gas supply unit 10 by adjusting the temperature of the heating wire coil 41 wound around the first hose 13 between the gas supply unit 10 and the drug dispenser 22.

[0101] Next, after administering all the medication from the drug syringe 21 into the peritoneal cavity 2 of the individual, the gas in the peritoneal cavity is circulated. At this time, the gas collected on the circulation unit 30 is in a state where its temperature has decreased due to heat transfer in the peritoneal cavity 2. Therefore, the temperature of the collected gas is raised by the heating coil 41 wound around the circulation hose 33. The temperature of the gas in the circulation hose 33 is measured by the second temperature sensor 43 and can be maintained at a predetermined set value.

[0102] Furthermore, gas lost within the abdominal cavity 2 of the individual may be replenished through the second hose 35, and the temperature of the gas in the second hose 35 may be lower than the temperature of the gas in the circulation hose 33. This allows the temperature of the gas in the circulation hose 33 to be maintained at 42°C or higher, and the set value of the temperature of the gas in the circulation hose 33 can be adjusted by the amount of gas supplied through the second hose 35.

[0103] In the circulation valve 34, the gas recovered from the abdominal cavity 2 and supplied by the circulation hose 33 and / or the gas supplied by the second hose 35 are mixed. A third temperature sensor 44 is positioned between the circulation valve 34 and the drug dispenser 22. The third temperature sensor 44 measures the temperature when the gas supplied by the circulation hose 33 and / or the gas supplied by the second hose 35 are mixed. The temperature control unit 40 can adjust the temperature of the coils wound around the circulation hose 33 and / or the coils wound around the second hose 35 based on the gas temperature measured by the third temperature sensor 44.

[0104] Furthermore, the first temperature sensor 42 measures the temperature of the gas discharged into the abdominal cavity 2 of the individual. Based on the measurement value of the first temperature sensor 42, the temperature control unit 40 can adjust the temperature of the gas measured by the third temperature sensor 44 to maintain the temperature inside the abdominal cavity 2 at 38 to 42°C, preferably 41 to 42°C, and more preferably 42°C, as described above.

[0105] Thus, the system 1 of the present invention, by including a plurality of temperature sensors 42, 43, 44 and a heating wire coil 41, and a temperature control unit 40 that controls them, can maintain the temperature inside the abdominal cavity 2 at a constant, predetermined value.

[0106] Second Example Figure 4 is a schematic diagram showing the configuration of a system device according to a second embodiment of the present invention. Figure 5 is a schematic diagram illustrating the system device shown in Figure 4 along with the flow of chemicals and gases.

[0107] Referring to Figures 4 and 5, System 1 (device) of this embodiment has a configuration similar to that of the first embodiment, except that the gas supply unit is directly connected to the circulation unit.

[0108] That is, the circulation unit 30 further includes a gas supply unit (10) that supplies gas in the circulation unit, where the gas supply unit includes a gas injector 11 that generates gas and a gas hose (third hose) through which the gas from the gas injector 11 flows and is connected to the circulation unit 30. The gas injector 11 may supply gas at a pressure of, for example, 12 to 14 bar, as in the first embodiment, and the pressure of the gas may be adjusted as it passes through the circulation pump 32.

[0109] Furthermore, the circulation unit 30 may further include a three-way valve (second valve) 34 into which the gas from the third hose and the gas from the circulation hose flows and which discharges the gas to the circulation pump 32. It may also further include a three-way valve (third valve) 34 into which gas flows from the circulation pump 32 and which supplies the gas to the drug and gas dispenser 22.

[0110] One or more gas hoses, for example two gas hoses, may be connected from the third valve to different positions on the drug and gas dispenser 22, for example, the head and the body.

[0111] As in the first embodiment, a temperature sensor (third temperature sensor) 44 for measuring the temperature of the gas in the gas hose connected to the body may be provided, and the other configurations and operations are also the same as in the first embodiment.

[0112] Third Example Figure 6 is a schematic diagram showing the configuration of a system device according to a third embodiment of the present invention. Figure 7 is a schematic diagram illustrating the system device shown in Figure 6 along with the flow of chemicals and gases.

[0113] Referring to Figures 6 and 7, System 1 (device) of this embodiment has a configuration similar to that of the second embodiment, except that one gas hose is connected from the three-way valve (third valve) 34 of the circulation unit 30 to the drug and gas injector 22, and the other gas hose is connected to the gas inlet trocar (hereinafter, second trocar) 37 of the sheathing device for gas injection that is sheathed into the abdominal cavity.

[0114] This allows for the drug and gas to be introduced into the peritoneal cavity together from the drug and gas injector 22, and for gas to be introduced into the peritoneal cavity from another second trocar. The rest of the configuration and operation are the same as in the second embodiment.

[0115] Fourth Embodiment Figure 8 is a schematic diagram showing the configuration of a system device according to a fourth embodiment of the present invention. Figure 9 is a schematic diagram illustrating the system device shown in Figure 8 along with the flow of chemicals and gases.

[0116] Referring to Figures 8 and 9, System 1 (device) of this embodiment has a configuration similar to that of the first embodiment, except that the gas injector 11 of the gas supply unit is connected to the head side of the drug and gas dispenser 22 without the need for a separate branch hose or pump.

[0117] Furthermore, in the circulation unit 30, a circulation hose 33 is connected to the body side of the drug and gas dispenser 22, and a second temperature sensor is attached to it to measure the temperature. The rest of the configuration and operation are the same as in the first embodiment.

[0118] Fifth Example Figure 10 is a schematic diagram showing the configuration of a system device according to the fifth embodiment of the present invention. Figure 11 is a schematic diagram illustrating the system device shown in Figure 10 along with the flow of chemicals and gases.

[0119] Referring to Figures 10 and 11, System 1 (device) of this embodiment has a configuration similar to that of the fourth embodiment, except that in the circulation unit 30, the circulation hose 33 is connected to a second trocar 37 of a separate sheathing device for gas injection, rather than to the drug and gas dispenser 22.

[0120] As in the first embodiment, the gas hose of the circulation unit 30 is equipped with a temperature sensor 43 for measuring the gas temperature. The other configurations and operations are the same as in the first embodiment.

[0121] Although embodiments of the present invention have been described in more detail above with reference to the attached drawings, the present invention is not necessarily limited to these embodiments and can be modified and implemented in various ways without departing from the technical concept of the present invention. Therefore, the embodiments disclosed herein are for illustrative purposes only, not to limit the technical concept of the present invention, and the scope of the technical concept of the present invention is not limited by such embodiments. Accordingly, the embodiments described above should be understood in all respects as illustrative and not limiting. The scope of protection of the present invention should be interpreted by the claims, and all technical concepts within an equivalent scope should be interpreted as being included in the scope of rights of the present invention. The present invention includes the following embodiments. <1> A system that circulates intraperitoneal thermal pressurizing gas, A gas circulation device comprising a gas hose connected to the abdominal cavity of an individual and a pump connected to the gas hose for circulating gas, which circulates gas discharged from the abdominal cavity back into the abdominal cavity; and A system characterized by including a temperature control device that controls the gas temperature of a gas circulation device so that the gas inside the abdominal cavity reaches a constant temperature. <2> The gas circulation device includes an intraperitoneal gas injection unit for introducing gas into the abdominal cavity; and a circulation unit for discharging gas from the abdominal cavity to the outside, circulating the gas outside the abdominal cavity, and then introducing it back into the abdominal cavity; The temperature control device includes a temperature sensor that measures one or more of the gas temperatures of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity; a heating device that provides heat to at least a portion of the gas hose of the gas circulation device; and a temperature control unit connected to the heating device and the temperature sensor. The temperature control unit is characterized by controlling the temperature of the heating device based on the measurement value of the temperature sensor so that the gas temperature inside the abdominal cavity becomes constant. <1> The system described above. <3> The intraperitoneal gas injection unit is characterized by including a drug and gas injection device that injects a drug together with the gas when gas is injected into the peritoneal cavity of an individual. <2> The system described above. <4> The aforementioned drug and gas injection device is a drug syringe that supplies the drug; A drug and gas injector connected to a gas hose to receive pressurized gas, receiving drug from the drug syringe, and fitted into the abdominal cavity to administer the drug and gas into the abdominal cavity of an individual; and The device is characterized by including a nozzle positioned at the end of the drug and gas injecting the drug and gas into the abdominal cavity; <3> The system described above. <5> The circulation unit includes a first trocar that is sheathed into the abdominal cavity and discharges gas, a circulation hose which is a gas hose connected to the first trocar, and a circulation pump connected to the circulation hose which increases the pressure of the circulating gas; The circulating gas of the circulating unit is supplied to the drug and gas dispenser, or to a second trocar fitted into the abdominal cavity, or to the drug and gas dispenser and the second trocar, characterized in that <4> The system described above. <6> The intraperitoneal gas injection unit further includes a gas supply unit that supplies gas to the drug and gas injection device, The gas supply unit includes a gas injector that generates gas; and A first hose through which the gas from the gas injector flows and which is connected to a chemical and gas injection device; is characterized by including <5> The system described above. <7> The gas supply unit further includes a pump that increases the pressure of the gas flowing through the first hose; <6> The system described above. <8> The gas supply unit further includes a second hose branched from the first hose, The circulation unit is characterized by further including a first valve into which gas from the circulation hose and the second hose flows and which discharges the gas to the drug and gas dispenser. <6> The system described above. <9> The circulation unit further includes a gas supply unit that supplies gas to the circulation unit, The gas supply unit includes a gas injector that generates gas; and A third hose through which the gas from the gas injector flows and which is connected to the circulation section; is characterized by including this, <5> The system described above. <10> The circulation unit further includes a second valve into which the gas from the third hose and the gas from the circulation hose flow and which discharges the gas to the circulation pump; <9> The system described above. <11> The circulation unit further includes a third valve through which gas flows in from a circulation pump and supplies gas to a drug and a gas dispenser; The third valve is connected to one or more gas hoses to a drug and gas dispenser, <9> The system described above. <12> The invention is characterized in that two gas hoses are connected from the third valve to different positions on the drug and gas dispenser, or one gas hose is connected from the third valve to the drug and gas dispenser, and the other gas hose is connected to the second trocar. <11> The system described above. <13> The heating device is a heating wire coil that is wound around at least a portion of the gas hose. The temperature control device includes a first temperature sensor that measures the temperature of the gas injected into the abdominal cavity; The heating element is characterized by controlling the temperature of the heating element coil based on the measurement value of the first temperature sensor so that the temperature of the gas inside the abdominal cavity is maintained at 38°C to 42°C. <5> The system described above. <14> The temperature control device is characterized by further including one or more of the following: a second temperature sensor for measuring the temperature of the gas in the circulation unit; and a third temperature sensor for measuring the temperature of the gas supplied from the circulation unit to the drug and gas dispenser. <13> The system described above. <15> The gas supply amount from each gas hose is adjusted based on the measurement value of one or more of the second temperature sensor and the third temperature sensor. <10> The system described above. <16> The aforementioned gas is characterized by being carbon dioxide. <1> ~ <15> A system as described in any one of the items. <17> The system is a system for intraperitoneal hyperthermic anticancer chemotherapy, and the drug is an anticancer agent. <1> ~ <15> A system as described in any one of the items. <18> A system for supplying intraperitoneal gas, The system includes a drug and gas injection device; The aforementioned drug and gas injection device is a drug syringe that supplies the drug; A drug and gas injector that receives a gas supply, receives a drug from the drug syringe, and is fitted into the abdominal cavity to administer the drug and gas into the abdominal cavity of an individual; and A system characterized by including a two-fluid nozzle positioned at the end of the drug and gas dispenser, which injects both the drug and gas into the abdominal cavity. <19> The system is a system for circulating intraperitoneal thermal pressurizing gas, A gas circulation device including a gas hose connected to the abdominal cavity and a pump connected to the gas hose for circulating gas, which circulates gas discharged from the abdominal cavity back into the abdominal cavity; and A temperature control device that controls the gas temperature of a gas circulation device so that the gas inside the abdominal cavity reaches a constant temperature; The gas circulation device is characterized by including the chemical agent and the gas injection device. <18> The system described above. <20> The gas circulation device includes an intraperitoneal gas injection unit for introducing gas into the abdominal cavity; and a circulation unit for discharging gas from the abdominal cavity to the outside, circulating the gas outside the abdominal cavity, and then introducing it back into the abdominal cavity; The intraperitoneal gas injection unit includes the drug and the gas injection device, The temperature control device includes a temperature sensor that measures one or more of the gas temperatures of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity; a heating device that provides heat to at least a portion of the gas hose of the gas circulation device; and a temperature control unit connected to the heating device and the temperature sensor. The temperature control unit is characterized by controlling the temperature of the heating device based on the measurement value of the temperature sensor so that the gas temperature inside the abdominal cavity becomes constant. <19> The system described above. <21> The circulation unit includes a first trocar that is sheathed into the abdominal cavity and discharges gas, a circulation hose which is a gas hose connected to the first trocar, and a circulation pump connected to the circulation hose which increases the pressure of the circulating gas; The circulating gas of the circulating unit is supplied to the drug and gas dispenser, or to a second trocar fitted into the abdominal cavity, or to the drug and gas dispenser and the second trocar, characterized in that <20> The system described above. <22> The intraperitoneal gas injection unit further includes a gas supply unit that supplies gas to the drug and gas injection device, The gas supply unit includes a gas injector that generates gas; and A first hose through which the gas from the gas injector flows and which is connected to a chemical and gas injection device; is characterized by including <21> The system described above. <23> The gas supply unit further includes a pump for increasing the pressure of the gas flowing through the first hose; and a second hose branched from the first hose; The circulation unit further includes a first valve into which gas from the circulation hose and the second hose flows and which discharges the gas to the drug and gas dispenser. <22> The system described above. <24> The circulation unit further includes a gas supply unit that supplies gas to the circulation unit, The gas supply unit includes a gas injector that generates gas; and Includes a third hose through which the gas from the gas injector flows and which is connected to the circulation section; The circulation unit further includes a second valve into which gas from the third hose and the circulation hose flows and which discharges the gas to the circulation pump; and a third valve into which gas from the circulation pump flows and which supplies the gas to the drug and gas dispenser; The invention is characterized in that two gas hoses are connected from the third valve to different positions on the drug and gas dispenser, or one gas hose is connected from the third valve to the drug and gas dispenser, and the other gas hose is connected to the second trocar. <21> The system described above. <25> The heating device is a heating wire coil that is wound around at least a portion of the gas hose. The temperature control device includes a first temperature sensor that measures the temperature of the gas injected into the abdominal cavity; The heating element is characterized by controlling the temperature of the heating element coil based on the measurement value of the first temperature sensor so that the temperature of the gas inside the abdominal cavity is maintained at 38°C to 42°C. <20> The system described above. <26> The temperature control device includes one or more of the following: a second temperature sensor for measuring the temperature of the gas in the circulation unit; and a third temperature sensor for measuring the temperature of the gas supplied from the circulation unit to the drug and gas dispenser. The gas flow rate to the gas hose is adjusted based on the measurement value of one or more of the second temperature sensor and the third temperature sensor. <25> The system described above. <27> The aforementioned two-fluid nozzle is A drug supply channel located at the center of the nozzle; A gas supply passage, consisting of two gas lines separately formed on either side of the drug guide; A mixing chamber connected to the aforementioned drug line and gas line, respectively, where the drug and gas are mixed; The mixing chamber is characterized by having an outlet for injecting a mixture of the drug and gas into the abdominal cavity. <18> The system described above. <28> The system is a system for intraperitoneal hyperthermic anticancer chemotherapy, characterized in that the drug is an anticancer agent and the gas is carbon dioxide. <18> ~ <27> A system as described in any one of the items. [Industrial applicability]

[0122] The system of the present invention is used as a system for intraperitoneal hyperthermic anticancer chemotherapy, and can maximize the anticancer treatment effect by more effectively delivering a small amount of anticancer drug to cancer cells while maintaining a constant gas temperature in the peritoneal cavity. [Explanation of Symbols]

[0123] 1: System 2: Inside the abdominal cavity 10: Gas supply unit 11: Gas injector 12: Pump 13: Hose 1 20: Drug sprayer 21: Drug syringe 22: Drug dispenser 23(23'): Nozzle (two-fluid nozzle) 30: Circulation section 31: First trocar 32: Circulation pump 33: Circulation hose 34: Circulation valve 35: Second hose 37: Second trocar 40: Temperature control unit 41: Heating coil 42: First temperature sensor 43: Second temperature sensor 44: Third temperature sensor 231: Pharmaceutical line 232: Gas line 233: Mixing chamber 234: Discharge port

Claims

1. A system that circulates intraperitoneal thermal pressurizing gas, A gas circulation device including a gas hose connected to the abdominal cavity of an individual, which circulates gas expelled from the abdominal cavity back into the abdominal cavity; and A temperature control device that controls the gas temperature of the gas circulation device so that the gas inside the abdominal cavity reaches a constant temperature; Includes, The aforementioned gas circulation device is An intraperitoneal gas injection unit for introducing gas into the abdominal cavity; and A circulatory unit that expels gas from the abdominal cavity to the outside, circulates the gas outside the abdominal cavity, and then reintroduces it into the abdominal cavity; Includes, The intraperitoneal gas injection unit includes a drug and gas injection device that injects a drug along with the gas when gas is injected into the peritoneal cavity of an individual; The aforementioned circulation unit is The first trocar, which is sheathed into the abdominal cavity to expel gas; A circulation pump that regulates the pressure of the circulating gas; A first circulation hose, which is a gas hose, is connected at one end to the first trocar and at the other end to the circulation pump via a first three-way valve; A second circulation hose, which is a gas hose, is connected at one end to the circulation pump and at the other end to the drug and gas dispenser and the second trocar via a second three-way valve; and The first three-way valve operates the path of the first circulation hose by opening and closing, thereby discharging the new gas flowing in from the gas hose connected to the first circulation hose and supplying new gas to the circulation pump, as well as the circulating gas flowing in from the first circulation hose, to the circulation pump; Includes, The aforementioned chemical agent and gas injection device are A drug syringe for supplying medication; A drug and gas injector connected to a gas hose to receive pressurized gas, receiving drug from the drug syringe, and fitted into the abdominal cavity to administer the drug and gas into the abdominal cavity of an individual; and A two-fluid nozzle, positioned at the end of the drug and gas dispenser, for injecting the drug and gas into the abdominal cavity; Includes, A system characterized in that the new gas and the circulating gas are introduced into the abdominal cavity along with the drug from the drug and gas injection device, and the new gas and the circulating gas are introduced into the abdominal cavity from the second trocar.

2. The temperature control device is A temperature sensor that measures the temperature of one or more gases, including the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity; A heating device that provides heat to at least a portion of the gas hose of the gas circulation device; and A temperature control unit connected to the heating device and a temperature sensor; Includes, The temperature control unit is characterized by controlling the temperature of the heating device based on the measurement value of the temperature sensor so that the gas temperature inside the abdominal cavity becomes constant. The system according to claim 1.

3. The intraperitoneal gas injection unit further includes a gas supply unit that supplies gas to the drug and gas injection device, The aforementioned gas supply unit, A gas injector that generates gas; and A first hose through which the gas from the gas injector flows, and which is connected to the chemical and gas injection device; The system according to claim 1 or 2, characterized by including the following:

4. The gas supply unit further includes a second hose branched from the first hose, The system according to claim 3, wherein the circulation unit further includes a first valve into which gas from the circulation hose and the second hose flows and which discharges the gas to a drug and gas dispenser.

5. The circulation unit further includes a gas supply unit that supplies gas to the circulation unit, The aforementioned gas supply unit, A gas injector that generates gas; and A third hose through which the gas from the aforementioned gas injector flows and which is connected to the circulation section; The system according to claim 1 or 2, characterized by including the following:

6. The heating device is a heating wire coil that is wound around at least a portion of the gas hose. The temperature control device includes a first temperature sensor for measuring the temperature of gas injected into the abdominal cavity; The heating element is characterized by controlling the temperature of the heating element coil based on the measurement value of the first temperature sensor so that the temperature of the gas inside the abdominal cavity is maintained at 38°C to 42°C. The system according to claim 2.

7. The temperature control device is A second temperature sensor for measuring the temperature of the gas in the circulation section; and A third temperature sensor that measures the temperature of the gas supplied from the circulation unit to the drug and gas dispenser; The system according to claim 6, further comprising one or more of the following.

8. The system according to claim 7, characterized in that it adjusts the amount of gas supplied from each gas hose based on the measurement value of one or more of the second temperature sensor and the third temperature sensor.

9. The system according to any one of claims 1, 2, 6 to 8, characterized in that the gas is carbon dioxide.

10. The system according to any one of claims 1, 2, 6 to 9, characterized in that the system is a system for intraperitoneal hyperthermic anticancer chemotherapy, and the drug is an anticancer agent.

11. The aforementioned two-fluid nozzle is A drug line located at the center of the nozzle, which is the passage through which the drug is supplied; A passage through which gas is supplied, and two gas lines formed separately on both sides of the aforementioned drug line; A mixing chamber connected to the aforementioned drug line and gas line, respectively, where the drug and gas are mixed; Includes, The system according to any one of claims 1, 2, 6 to 10, characterized in that the mixing chamber is provided with an outlet for injecting a mixture of the drug and gas into the abdominal cavity.

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