Deuterated 2-aromatic heterocyclic-3-oxo-2,3-dihydropyridazine-4-carboxamide inhibitors, methods for producing the same, and applications
Deuterated 3-oxo-2,3-dihydropyridazine-4-carboxamide compounds provide selective AhR inhibition, addressing the need for effective cancer treatment by targeting AhR-mediated immunosuppression and enhancing immunotherapy.
JP7869210B2Active Publication Date: 2026-06-02SUZHOU ZELGEN BIOPHARML +1
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- SUZHOU ZELGEN BIOPHARML
- Filing Date
- 2021-11-29
- Publication Date
- 2026-06-02
AI Technical Summary
Technical Problem
There is a need for highly selective and active Aryl Hydrocarbon Receptor (AhR) inhibitors to treat diseases such as cancer mediated by AhR abnormalities while minimizing off-target effects.
Method used
Development of deuterated 3-oxo-2,3-dihydropyridazine-4-carboxamide compounds with specific structural formulas and their derivatives, including stereoisomers, crystal forms, pharmaceutically acceptable salts, hydrates, and solvates, which exhibit selective inhibitory effects on AhR.
Benefits of technology
The compounds effectively inhibit AhR, potentially treating tumors and other diseases by reducing immunosuppression and enhancing immunotherapy efficacy, with minimal off-target effects.
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Smart Images
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Abstract
The present invention relates to a deuterated 3-oxo-2,3-dihydropyridazine-4-carboxamide inhibitor, its preparation method, and application. Specifically, the compound of the present invention has a structure represented by formula (I). The present invention further discloses a preparation method of the compound and its use as an AhR inhibitor. The compound of the present invention has excellent selectivity for inhibiting AhR, as well as superior pharmacodynamic and pharmacokinetic properties, and reduced toxicity and side effects. [Formula 1] JPEG2023551019000050.jpg4162
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